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https://www.readbyqxmd.com/read/29353383/religion-and-well-being-the-mediating-role-of-positive-virtues
#1
Swati Sharma, Kamlesh Singh
Researchers have consistently advocated positive associations between religion and well-being. The present research takes a step forward and explores potential mechanisms behind the same. The mediating role of a surprisingly neglected mechanism, positive virtues, specifically gratitude, forgiveness and altruism, is studied through a quantitative study on a sample of 220 adult respondents residing in Delhi NCR. The participants adhered to one of the six major religions present in India. Mediational analysis revealed that gratitude mediated the relationship between religiosity, spirituality and well-being via two pathways of forgiveness and altruism...
January 20, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29348810/structure-based-virtual-screening-for-the-discovery-of-novel-inhibitors-of-new-delhi-metallo-%C3%AE-lactamase-1
#2
Francesca Spyrakis, Giuseppe Celenza, Francesca Marcoccia, Matteo Santucci, Simon Cross, Pierangelo Bellio, Laura Cendron, Mariagrazia Perilli, Donatella Tondi
Bacterial resistance has become a worldwide concern after the emergence of metallo-β-lactamases (MBLs). They represent one of the major mechanisms of bacterial resistance against beta-lactam antibiotics. Among MBLs, New Delhi metallo-β-lactamase-1 NDM-1, the most prevalent type, is extremely efficient in inactivating nearly all-available antibiotics including last resort carbapenems. No inhibitors for NDM-1 are currently available in therapy, making the spread of NDM-1 producing bacterial strains a serious menace...
January 11, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29344961/in-vivo-evaluation-of-some-biophysical-parameters-of-the-facial-skin-of-indian-subjects-living-in-mumbai-part-ii-variability-with-age-and-gender
#3
Loïc Colomb, Frederic Flament, Anupama Wagle, Youssef Idelcaid, Divya Agrawal
BACKGROUND: A previously published work explored the diversity of some biophysical parameters (colour, elasticity, sebum production, skin micro relief….) of the skin of 1204 Indian women, differently aged, living in 4 Indian cities (Chennai, Delhi, Kolkata, Mumbai). The present work aimed at completing such research by focusing on possible gender-related differences in the same skin parameters, between Indian men and women living in the same Indian city (Mumbai). METHODS: 297 Indian men, differently aged (18-70y) were recruited in Mumbai, completing the panel of 303 women who were previously recruited in this same city...
January 17, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29344047/a-comparative-study-of-shift-work-effects-and-injuries-among-nurses-working-in-rotating-night-and-day-shifts-in-a-tertiary-care-hospital-of-north-india
#4
Anjana Verma, Jugal Kishore, Shobha Gusain
Background: Shift work can have an impact on the physical and psychological well-being of the healthcare worker, affecting patients as well as their own safety at the workplace. This study was conducted to compare the health outcomes and injuries, along with associated risk factors between the nurses working in rotating night shift (RNS) as compared to day shift (DS) only. Materials and Methods: It was a cross-sectional study conducted from June to November 2016 in a tertiary care hospital of Delhi...
January 2018: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29339760/biochemical-and-genetic-characterization-of-a-novel-metallo-%C3%AE-lactamase-from-marine-bacterium-erythrobacter-litoralis-htcc-2594
#5
Xia-Wei Jiang, Hong Cheng, Ying-Yi Huo, Lin Xu, Yue-Hong Wu, Wen-Hong Liu, Fang-Fang Tao, Xin-Jie Cui, Bei-Wen Zheng
Metallo-β-lactamases (MBLs) are a group of enzymes that can inactivate most commonly used β-lactam-based antibiotics. Among MBLs, New Delhi metallo-β-lactamase-1 (NDM-1) constitutes an urgent threat to public health as evidenced by its success in rapidly disseminating worldwide since its first discovery. Here we report the biochemical and genetic characteristics of a novel MBL, ElBla2, from the marine bacterium Erythrobacter litoralis HTCC 2594. This enzyme has a higher amino acid sequence similarity to NDM-1 (56%) than any previously reported MBL...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29336873/optimization-of-novel-monobactams-with-activity-against-carbapenem-resistant-enterobacteriaceae-identification-of-lys228
#6
Folkert Reck, Alun Bermingham, Johanne Blais, Vladimir Capka, Taryn Cariaga, Anthony Casarez, Richard Colvin, Charles R Dean, Alex Fekete, Wanben Gong, Ellie Growcott, Hongqiu Guo, Adriana K Jones, Cindy Li, Fengxia Li, Xiaodong Lin, Mika Lindvall, Sara Lopez, David McKenney, Louis Metzger, Heinz E Moser, Ramadevi Prathapam, Dita Rasper, Patrick Rudewicz, Vijay Sethuraman, Xiaoyu Shen, Jacob Shaul, Robert L Simmons, Kyuto Tashiro, Dazhi Tang, Meiliana Tjandra, Nancy Turner, Tsuyoshi Uehara, Charles Vitt, Steven Whitebread, Aregahegn Yifru, Xu Zang, Qingming Zhu
Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers resistance in Gram-negative bacteria to all classes of β-lactam antibiotics, with the exception of monobactams, which are intrinsically stable to MBLs. However, existing first generation monobactam drugs like aztreonam have limited clinical utility against MBL-expressing strains because they are impacted by serine β-lactamases (SBLs), which are often co-expressed in clinical isolates...
January 4, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29332105/the-emergence-of-carbapenem-resistant-klebsiella-pneumoniae-isolates-producing-oxa-48-and-ndm-in-the-southern-asir-province-saudi-arabia
#7
Ibrahim A Al-Zahrani, Bander A Alsiri
To identify the prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) and the most common types of cabapenemases among CRKP in the Southern (Asir) province hospitals, Saudi Arabia. Methods: The cross-sectional study was conducted between late April and September in 2015. A total of 54 Klebsiella pneumoniae (K. pneumoniae) isolates with reduced sensitivity to carbapenems were obtained from various clinical specimens of the 2 largest hospitals in the Southern province. Minimum inhibitory concentrations (MICs) of carbapenems were confirmed using E-test...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29327190/chemical-characterization-and-quantitativ-e-assessment-of-source-specific-health-risk-of-trace-metals-in-pm1-0-at-a-road-site-of-delhi-india
#8
Jai Prakash, Tarachand Lohia, Anil K Mandariya, Gazala Habib, Tarun Gupta, Sanjay K Gupta
This study presents the concentration of submicron aerosol (PM1.0) collected during November, 2009 to March, 2010 at two road sites near the Indian Institute of Technology Delhi campus. In winter, PM1.0 composed 83% of PM2.5 indicating the dominance of combustion activity-generated particles. Principal component analysis (PCA) proved secondary aerosol formation as a dominant process in enhancing aerosol concentration at a receptor site along with biomass burning, vehicle exhaust, road dust, engine and tire tear wear, and secondary ammonia...
January 11, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29326494/experience-of-an-academic-institute-in-importing-a-novel-preclinical-drug-into-india
#9
M Praveen Kumar, Bikash Medhi
The article throws light on the process of importing a novel preclinical drug into India based on the real-life experience from one of our studies. A novel drug "X" acting through a new mechanism of action was hypothesized by us to function as a neuroprotectant. It was decided to import this novel drug from a university located in Brazil. An official collaboration pact was exchanged between both the sides. In accordance with the Indian Drug and Cosmetics Act 1940, unauthorized import of drug into India is not permitted...
July 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29321998/effectiveness-of-two-different-herbal-toothpaste-formulations-in-the-reduction-of-plaque-and-gingival-inflammation-in-patients-with-established-gingivitis-a-randomized-controlled-trial
#10
Rajesh Hosadurga, Vinita Ashutosh Boloor, Sudharshan N Rao, N MeghRani
Background: Plant based toothpastes have received great attention in reducing gingival inflammation. Studies show contrasting results regarding the effectiveness of these toothpastes. In the present study, the effectiveness of two herbal tooth paste formulations in the reduction of plaque and gingival inflammation was assessed. Nicotine content in the toothpastes was assessed using GCMS. Material and methods: 50 patients with established gingivitis were included in the study...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29319026/sequelae-of-pulmonary-multidrug-resistant-tuberculosis-at-the-completion-of-treatment
#11
Rupak Singla, Manashree Mallick, Parul Mrigpuri, Neeta Singla, Amitesh Gupta
BACKGROUND: Treatment of multidrug-resistant (MDR-TB) mainly focuses on bacteriological cure. However, only limited studies have evaluated the sequelae left after the completion of treatment among MDR-TB patients. OBJECTIVE: To assess the persistent symptoms, radiological sequelae, pulmonary function impairment and quality of life at the completion of treatment among MDR-TB patients. METHODS: Forty six MDR-TB patients were enrolled, who completed two years of treatment under programmatic management of Drug Resistant tuberculosis at a tertiary referral institute in Delhi, India...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29317889/clinical-and-laboratory-analysis-of-patients-with-leishmaniasis-a-retrospective-study-from-a-tertiary-care-center-in-new-delhi
#12
Nitin Gupta, Kamla Kant, Bijay Ranjan Mirdha
Background: Leishmaniasis manifests as visceral (VL), cutaneous (CL) or a dermal sequel of VL, known as Post kala-azar dermal leishmaniasis (PKDL). The aim of the study was to analyze the clinical and laboratory features of cases diagnosed with leishmaniasis. Methods: This hospital-based retrospective study included all cases of VL, PKDL, and CL diagnosed between Jan 2011 to Jan 2016 at All India Institute of Medical Sciences, New Delhi. Clinical and laboratory profile of the diagnosed cases were analyzed in detail...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29317558/childhood-cancer-incidence-in-india-betweem-2012-and-2014-report-of-a-population-based-cancer-registry
#13
Suman Das, Dilip Kumar Paul, Kumar Anshu, Subhajit Bhakta
OBJECTIVE: To provide an overview of childhood cancer incidence in India between 2012-2014. METHODS: Secondary data analysis on age-adjusted rates of cancer incidence for children (0-14 years) were collected from the report of the National Cancer Registry Programme in the year 2016. RESULTS: Age-adjusted rates of childhood cancer incidence ranged from 18.5 per million in the state of Nagaland to 235.3 per million in Delhi for boys. The rates were 11...
December 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29313584/an-interesting-case-of-recurrent-pyelonephritis
#14
Achintya Dinesh Singh, Siddharth Jain, Agrima Mian, Surabhi Vyas, Neeraj Nischal, Pankaj Jorwal
A 35-year-old male presented with repeated episodes of fever and abdominal pain of 3-month duration. He had been hospitalized twice with similar complaints in the past 3-month. He was diagnosed as pyelonephritis and managed with intravenous antibiotics. However, fever recurred after ten days of discharge from the hospital. With these complaints, he was referred to the Department of Medicine, AIIMS, New Delhi. After evaluation, he was diagnosed as pyelonephritis with right sided consolidation and was started on broad spectrum antibiotics...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29311090/investigation-of-multiple-resistance-mechanisms-in-voriconazole-resistant-aspergillus-flavus-clinical-isolates-from-a-chest-hospital-surveillance-in-delhi-india
#15
Cheshta Sharma, Rakesh Kumar, Nitin Kumar, Aradhana Masih, Dinesh Gupta, Anuradha Chowdhary
Invasive and allergic infections by Aspergillus flavus are more common in tropical and subtropical countries. The emergence of voriconazole (VRC) resistance in A. flavus impacts the management of aspergillosis as azoles are used as the first line and empiric therapy. We screened molecularly confirmed 120 A. flavus isolates obtained from respiratory and sino-nasal specimens in a chest hospital in Delhi for azole resistance using CLSI BMD method. Overall, 2.5% (n=3/120) of A. flavus isolates had VRC MICs above epidemiological cutoff values (>1μg/ml)...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29302511/need-of-department-of-general-practice-family-medicine-at-aiims-all-india-institute-of-medical-sciences-why-the-apex-medical-institute-in-india-should-also-contribute-towards-training-and-education-of-general-practitioners-and-family-physicians
#16
EDITORIAL
Ranabir Pal, Raman Kumar
Family medicine or general practice is the practicing discipline of the majority doctors in India, however formal academic departments of general practice (or family medicine) do not exist in India, as it is not a mandatory requirement as prescribed by the Medical Council of India; the principal regulator of medical education. Currently India has capacity to produce more than 60,000 medical graduates per year, majority of whom are expected to become general practitoners or primary care doctors without under going any vocational training in general practice or family medicine...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29301875/metagenomics-study-of-contaminated-sediments-from-the-yamuna-river-at-kalindi-kunj-delhi-india
#17
Nishi Sahu, Maushumi Deori, Ilora Ghosh
The Yamuna River is the backbone of domestic, irrigation, and industrial activities in Delhi, India, yet the complex dynamics of its microbes and their contribution to biogeochemical cycles in a polluted environment remain elusive. This is an introductory report describing the microbial community in the Yamuna River, using high-throughput metagenomics.
January 4, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29298980/author-correction-ultrafast-bridge-planarization-in-donor-%C3%AF-acceptor-copolymers-drives-intramolecular-charge-transfer
#18
Palas Roy, Ajay Jha, Vineeth B Yasarapudi, Thulasi Ram, Boregowda Puttaraju, Satish Patil, Jyotishman Dasgupta
The original version of this Article omitted the following from the Acknowledgements:"Satish Patil thanks Department of Science and Technology, New Delhi, India for a Swarnajayanti fellowship."This has now been corrected in both the PDF and HTML versions of the Article.
January 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/29296273/new-delhi-metallo-%C3%AE-lactamase-1-producing-klebsiella-pneumoniae-isolates-in-hospitalized-patients-in-kashan-iran
#19
Farzaneh Firoozeh, Zeinab Mahluji, Ehsaneh Shams, Ahmad Khorshidi, Mohammad Zibaei
Background and Objectives: New Delhi metallo-ß-lactamase (NDM) is a newly emerging metallo-ß-lactamases, which can destroy all β-lactams including carbapenems. Therefore, this study aimed at evaluating New Delhi metallo-ß-lactamase-1-production in clinical isolates of Klebsiella pneumoniae in Kashan, Iran. Materials and Methods: In a cross-sectional study, 181 K. pneumoniae isolates were collected from clinical samples of patients, who referred to Shahid Beheshi hospital in Kashan during November 2013 and October 2014...
October 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29291235/molecular-evidence-for-the-occurrence-of-tomato-leaf-curl-new-delhi-virus-on-chayote-sechium-edule-in-southern-india
#20
K Nagendran, S Mohankumar, P Mohammed Faisal, B Bagewadi, G Karthikeyan
During 2012-2014, mosaic disease on chayote in the farmers field of Kodaikanal region (high altitude zone) of Tamil Nadu was observed. The disease was characterized with severe mosaic, cupping and enation on leaves with reduced fruit size. Disease was found to causes an yield loss of more than 60% with the maximum disease incidence of 100% for the past 5 years consecutively. Preliminary serological and molecular screening indicated the association of begomovirus with the disease. Complete nucleotide sequence and phylogenetic analysis of DNA A revealed the identity of the virus as tomato leaf curl New Delhi virus (ToLCNDV)...
December 2017: Virusdisease
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