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https://www.readbyqxmd.com/read/28106831/ablation-of-protein-kinase-ck2%C3%AE-in-skeletal-muscle-fibers-interferes-with-their-oxidative-capacity
#1
Nane Eiber, Luca Simeone, Said Hashemolhosseini
The tetrameric protein kinase CK2 was identified playing a role at neuromuscular junctions by studying CK2β-deficient muscle fibers in mice, and in cultured immortalized C2C12 muscle cells after individual knockdown of CK2α and CK2β subunits. In muscle cells, CK2 activity appeared to be at least required for regular aggregation of nicotinic acetylcholine receptors, which serves as a hallmark for the presence of a postsynaptic apparatus. Here, we set out to determine whether any other feature accompanies CK2β-deficient muscle fibers...
January 19, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28106620/effects-of-histidine-and-%C3%AE-alanine-supplementation-on-human-muscle-carnosine-storage
#2
Laura Blancquaert, Inge Everaert, Maarten Missinne, Audrey Baguet, Sanne Stegen, Anneke Volkaert, Mirko Petrovic, Chris Vervaet, Eric Achten, Mieke De Maeyer, Stefaan De Henauw, Wim Derave
PURPOSE: Carnosine is a dipeptide composed of β-alanine and L-histidine and is present in skeletal muscle. Chronic oral β-alanine supplementation can induce muscle carnosine loading and is therefore seen as the rate-limiting factor for carnosine synthesis. However, the effect of L-histidine supplementation on carnosine levels in humans is never established. This study aims to investigate whether 1) L-histidine supplementation can induce muscle carnosine loading and 2) combined supplementation of both amino acids is more efficient than β-alanine supplementation alone...
January 19, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28102177/erratum-an-action-potential-driven-model-of-soleus-muscle-activation-dynamics-for-locomotor-like-movements-2015-j-neural-eng-12-046025
#3
Hojeong Kim, Thomas Sandercock, C Heckman
We published our study on modelling ans simulation of force production in cat soleus muscles during locomotor-like movements. Unfortunately, we recently found several typographical errors in equation (15), table 1 and figure 3E in the published paper. Those errors arose from mistakes on our part during transitioning of our manuscript from the paper to electronic version. We have confirmed that correction of our errors does not influence any simulation results and conclusions published in our paper. However, we think that the errors and their corrections should be noticed publically to prevent the readers from having difficulties in implementing our muscle model...
January 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28096436/angiotensin-ii-induces-differential-insulin-action-in-rat-skeletal-muscle
#4
Juthamard Surapongchai, Mujalin Prasannarong, Tepmanas Bupha-Intr, Vitoon Saengsirisuwan
Angiotensin II (ANGII) is reportedly involved in the development of skeletal muscle insulin resistance. The present investigation evaluated the effects of two ANGII doses on the phenotypic characteristics of insulin resistance syndrome and insulin action and signaling in rat skeletal muscle. Male Sprague-Dawley rats were infused with either saline (SHAM) or ANGII at a commonly used pressor dose (100 ng/kg/min; ANGII-100) or a higher pressor dose (500 ng/kg/min; ANGII-500) via osmotic minipumps for 14 days. We demonstrated that ANGII-100-infused rats exhibited the phenotypic features of non-obese insulin resistance syndrome, including hypertension, impaired glucose tolerance and insulin resistance of glucose uptake in the soleus muscle, whereas ANGII-500-treated rats exhibited diabetes-like symptoms, such as post-prandial hyperglycemia, impaired insulin secretion and hypertriglyceridemia...
January 17, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28095499/treatment-with-riluzole-restores-normal-control-of-soleus-and-extensor-digitorum-longus-muscles-during-locomotion-in-adult-rats-after-sciatic-nerve-crush-at-birth
#5
Wojciech Zmysłowski, Anna M Cabaj, Urszula Sławińska
The effects of sciatic nerve crush (SNC) and treatment with Riluzole on muscle activity during unrestrained locomotion were identified in an animal model by analysis of the EMG activity recorded from soleus (Sol) and extensor digitorum longus (EDL) muscles of both hindlimbs; in intact rats (IN) and in groups of rats treated for 14 days with saline (S) or Riluzole (R) after right limb nerve crush at the 1st (1S and 1R) or 2nd (2S and 2R) day after birth. Changes in the locomotor pattern of EMG activity were correlated with the numbers of survived motor units (MUs) identified in investigated muscles...
2017: PloS One
https://www.readbyqxmd.com/read/28093618/mri-assessment-of-calf-injuries-in-australian-football-league-players-findings-that-influence-return-to-play
#6
George Waterworth, Sara Wein, Alexandra Gorelik, Andrew H Rotstein
OBJECTIVE: Calf muscle strains have become increasingly prevalent in recent seasons of the Australian Football League (AFL) and represent a significant cause of time lost from competition. The purpose of this study was to examine the association between MRI features of calf muscle strains and games missed and to thereby identify parameters that are of prognostic value. MATERIALS AND METHODS: A retrospective analysis of MRI scans of AFL players with calf strains referred to a musculoskeletal radiology clinic over a 5-year period (2008-2012) was performed...
January 16, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28093306/establishing-between-session-reliability-of-tms-conditioned-soleus-h-reflexes
#7
W A Gray, M J Sabatier, T M Kesar, M R Borich
Transcranial magnetic stimulation (TMS) of the primary motor cortex (M1) can be used to evaluate descending corticomotor influences on spinal reflex excitability through modulation of the Hoffman reflex (H-reflex). The purpose of this study was to characterize between-session reliability of cortical, spinal, and cortical-conditioned spinal excitability measures collected from the soleus muscle. Thirteen able-bodied young adult participants were tested over four sessions. Intraclass correlation coefficients were calculated to quantify between-session reliability of active motor threshold (AMT), unconditioned H-reflexes (expressed as a percentage of Mmax), and conditioned H-reflexes using short-latency facilitation (SLF) and long-latency facilitation (LLF)...
January 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28089828/nitrite-increases-glucose-stimulated-insulin-secretion-and-islet-insulin-content-in-obese-type-2-diabetic-male-rats
#8
Sevda Gheibi, Fatemeh Bakhtiarzadeh, Sajad Jeddi, Khadijeh Farrokhfall, Homeira Zardooz, Asghar Ghasemi
PURPOSE: Reduced bioavailability of nitric oxide (NO) is associated with pathogenesis of type 2 diabetes. Nitrite can act as a substrate for generation of systemic NO. The aim of this study was to examine the effects of nitrite administration on glucose-stimulated insulin secretion (GSIS) and islet insulin content in obese type 2 diabetic rats. METHODS: Male rats were divided into 4 groups: Control, control + nitrite, diabetes, and diabetes + nitrite. Sodium nitrite (50 mg/L in drinking water) was administered for 8 weeks...
January 9, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28088654/transcriptional-response-of-skeletal-muscle-to-a-low-protein-perinatal-diet-in-rat-offspring-at-different-ages-the-role-of-key-enzymes-of-glucose-fatty-acid-oxidation
#9
José Luiz de Brito Alves, Ana Elisa Toscano, João Henrique da Costa-Silva, Hubert Vidal, Carol Góis Leandro, Luciano Pirola
Skeletal muscle is a plastic tissue during development with distinctive acute and chronic response to maternal protein restriction. This study evaluated gene and protein expression of key-enzymes of glycolytic pathway (HK2, PFK, PDK4 and CS), and fatty acid oxidation (CPT1 and β-HAD) of two different types of skeletal muscle [soleus and extensor digitorium longus (EDL)] from offspring rats at 30 and 90 days of age, exposed to maternal isoenergetic low protein diet throughout gestation and lactation. Pups from dams fed 17% protein diet (n=5, normal protein, Np), and low protein pups from dams fed 8% casein diet (low protein, Lp, n=5) were evaluated...
December 15, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28087756/fine-mapping-of-genes-determining-extrafusal-fiber-properties-in-murine-soleus-muscle
#10
Andrew Carroll, Riyan Cheng, Elaina Collie-Duguid, Caroline Meharg, Michael E Scholz, Steven N Fiering, Jennifer L Fields, Abraham A Palmer, Arimantas Lionikas
INTRODUCTION: Muscle fiber cross-sectional area (CSA) and proportion of different fiber types are important determinants of muscle function and overall metabolism. Genetic variation plays a substantial role in phenotypic variation of these traits, however, the underlying genes remain poorly understood. AIMS: This study aimed to map quantitative trait loci (QTL) affecting differences in soleus muscle fiber traits between the LG/J and SM/J mouse strains. METHODS: Fiber number, CSA, and proportion of oxidative type I fibers were assessed in the soleus of 334 genotyped male and female mice of the F34 generation of advanced intercross lines (AIL) derived from the LG/J and SM/J strains...
January 13, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28077666/motor-plan-differs-for-young-and-older-adults-during-similar-movements
#11
Agostina Casamento Moran, Yen-Ting Chen, Neha Lodha, Basma Yacoubi, Evangelos A Christou
Older adults exhibit altered activation of the agonist and antagonist muscles during goal-directed movements compared with young adults. However, it remains unclear whether the differential activation of the antagonistic muscles in older adults results from an impaired motor plan or an altered ability of the muscle to contract. The purpose of this study, therefore, was to determine whether the motor plan differs for young and older adults. Ten young (26.1 ± 4.3 yrs, 4 females) and sixteen older (71.9 ± 6...
January 11, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28076365/gene-expression-profiling-in-slow-type-calf-soleus-muscle-of-30-days-space-flown-mice
#12
Guido Gambara, Michele Salanova, Stefano Ciciliot, Sandra Furlan, Martina Gutsmann, Gudrun Schiffl, Ute Ungethuem, Pompeo Volpe, Hanns-Christian Gunga, Dieter Blottner
Microgravity exposure as well as chronic disuse are two main causes of skeletal muscle atrophy in animals and humans. The antigravity calf soleus is a reference postural muscle to investigate the mechanism of disuse-induced maladaptation and plasticity of human and rodent (rats or mice) skeletal musculature. Here, we report microgravity-induced global gene expression changes in space-flown mouse skeletal muscle and the identification of yet unknown disuse susceptible transcripts found in soleus (a mainly slow phenotype) but not in extensor digitorum longus (a mainly fast phenotype dorsiflexor as functional counterpart to soleus)...
2017: PloS One
https://www.readbyqxmd.com/read/28070911/effects-of-exercise-training-on-brain-derived-neurotrophic-factor-in-skeletal-muscle-and-heart-of-rats-post-myocardial-infarction
#13
Heow Won Lee, Monir Ahmad, Hong-Wei Wang, Frans H H Leenen
Exercise training post myocardial infarction (MI) attenuates progressive left ventricle (LV) remodeling and dysfunction, but the peripheral stimuli induced by exercise which trigger these beneficial effects are still unclear. We investigated as possible mediators fibronectin type III domain-containing protein 5 (FNDC5) and brain-derived neurotrophic factor (BDNF) in the skeletal muscle and heart. Male Wistar rats underwent either sham surgery or ligation of left descending coronary artery, and surviving MI rats were allocated to either sedentary (Sed-MI) or exercise group (ExT-MI)...
January 9, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28053000/myoblast-replication-is-reduced-in-the-iugr-fetus-despite-maintained-proliferative-capacity-in-vitro
#14
Susan M Soto, Amy C Blake, Stephanie R Wesolowski, Paul J Rozance, Kristen B Barthel, Bifeng Gao, Byron Hetrick, Carrie McCurdy, Natalia G Garza, William Hay, Leslie A Leinwand, Jacob E Friedman, Laura D Brown
Adults who were affected by intrauterine growth restriction (IUGR) suffer from reductions in muscle mass and insulin resistance, suggesting muscle growth may be restricted by molecular events that occur during fetal development. To explore the basis of restricted fetal muscle growth, we used a sheep model of progressive placental insufficiency-induced IUGR to assess myoblast proliferation within intact skeletal muscle in vivo and isolated myoblasts stimulated with insulin in vitro. Gastrocnemius and soleus muscle weights were reduced by 25% in IUGR fetuses compared to controls (CON)...
January 4, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28050266/from-slow-to-fast-hypogravity-induced-remodeling-of-muscle-fiber-myosin-phenotype
#15
B S Shenkman
Skeletal muscle consists of different fiber types arranged in a mosaic pattern. These fiber types are characterized by specific functional properties. Slow-type fibers demonstrate a high level of fatigue resistance and prolonged contraction duration, but decreased maximum contraction force and velocity. Fast-type fibers demonstrate high contraction force and velocity, but profound fatigability. During the last decades, it has been discovered that all these properties are determined by the predominance of slow or fast myosin-heavy-chain (MyHC) isoforms...
October 2016: Acta Naturae
https://www.readbyqxmd.com/read/28041995/osteoprotegerin-and-%C3%AE-2-agonists-mitigate-muscular-dystrophy-in-slow-and-fast-twitch-skeletal-muscles
#16
Sébastien S Dufresne, Antoine Boulanger-Piette, Jérôme Frenette
Our recent work showed that daily injections of osteoprotegerin (OPG)-immunoglobulin fragment complex (OPG-Fc) completely restore the function of fast-twitch extensor digitorum longus muscles in dystrophic mdx mice, a murine model of Duchenne muscular dystrophy. However, despite marked improvements, OPG-Fc was not as effective in preventing the loss of function of slow-twitch soleus and diaphragm muscles. Because β2-agonists enhance the function of slow- and fast-twitch dystrophic muscles and because their use is limited by their adverse effects on bone and cardiac tissues, we hypothesized that OPG-Fc, a bone and skeletal muscle protector, acts synergistically with β2-agonists and potentiates their positive effects on skeletal muscles...
December 30, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/28039767/static-otolithic-drive-alters-presynaptic-inhibition-in-soleus-motor-pool
#17
Apollonia Fox, David Koceja
The vestibular system has both direct and indirect connections to the soleus motor pool via the vestibulospinal and reticulospinal tracts. The exact nature of how this vestibular information is integrated within the spinal cord is largely unknown. The purpose of this study was to identify whether changes in static otolithic drive altered the amount of presynaptic inhibition in the soleus H-reflex pathway. Changes in static otolithic drive were investigated in sixteen healthy participants using a tilt table...
December 20, 2016: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28035013/alterations-to-mitochondrial-fatty-acid-use-in-skeletal-muscle-after-chronic-exposure-to-hypoxia-depend-on-metabolic-phenotype
#18
Alexandra Malgoyre, Clovis Chabert, Julia Tonini, Nathalie Koulmann, Xavier Bigard, Hervé Sanchez
We investigated the effects of chronic hypoxia on the maximal use of and sensitivity of mitochondrial to different substrates in rat slow-oxidative (soleus, SOL) and fast-glycolytic (extensor digitorum longus, EDL) muscles. We studied mitochondrial respiration in situ in permeabilized myofibers, using pyruvate, octanoate, palmitoyl-carnitine (PC) or palmitoyl-coenzyme A (PCoA). The hypophagia induced by hypoxia may also alter metabolism. We therefore used a group of pair-fed rats (reproducing the same caloric restriction as observed in hypoxic animals) in addition to the normoxic control fed ad libitum...
December 29, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28034458/corrigendum-to-acute-effects-of-stretching-exercise-on-the-soleus-muscle-of-female-aged-rats-acta-histochem-118-1-2016-1-9
#19
Talita Gianello Gnoato Zotz, Luiz Guilherme A Capriglione, Rafael Zotz, Lucia Noronha, Marina Louise Viola De Azevedo, Hilana Rickli Fiuza Martins, Anna Raquel Silveira Gomes
No abstract text is available yet for this article.
December 26, 2016: Acta Histochemica
https://www.readbyqxmd.com/read/28033657/neuromuscular-responses-of-the-plantar-flexors-to-whole-body-vibration
#20
B Harwood, J Scherer, R E Brown, K M D Cornett, K A Kenno, J M Jakobi
Enhanced physical performance following whole-body vibration (WBV) has been attributed to increased muscle activity; however, few studies have measured the mechanisms underlying these changes. The objective of this study was to measure the responsiveness of the Ia pathway as well as contractile properties in 16 young adults (24±2 years, eight men, eight women) following repeated bouts of acute WBV (45 Hz, 2 mm). Hoffman reflexes (H-reflex), compound muscle action potentials (M-wave), and twitch contractile properties were measured prior to and immediately following five 1-minute WBV exposures, and at 3, 5, 10, and 20 minute post-WBV...
December 29, 2016: Scandinavian Journal of Medicine & Science in Sports
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