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https://www.readbyqxmd.com/read/29774825/dietary-zinc-modulates-matrix-metalloproteinases-in-traumatic-brain-injury
#1
Angus Scrimgeour, Christopher Carrigan, Michelle Lynn Condlin, Maria L Urso, Roland M van den Berg, Herman P M van Helden, Scott J Montain, Marloes J A Joosen
Animal models of mild traumatic brain injury (mTBI) provide opportunity to examine the extent to which dietary interventions can be used to improve recovery after injury. Animal studies also suggest that matrix metalloproteinases (MMPs) play a role in tissue remodeling post-TBI. Because dietary zinc (Zn) improved recovery in non-blast mTBI models, and the MMPs are Zn-requiring enzymes, we evaluated the effects of low- and adequate Zn diets on MMP expression and behavioral responses, following exposure to a single blast...
May 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29774305/multi-slice-mri-reveals-heterogeneity-in-disease-distribution-along-the-length-of-muscle-in-duchenne-muscular-dystrophy
#2
Stephen M Chrzanowski, Celine Baligand, Rebecca J Willcocks, Jasjit Deol, Ilona Schmalfuss, Donovan J Lott, Michael J Daniels, Claudia Senesac, Glenn A Walter, Krista Vandenborne
Background: Duchenne muscular dystrophy (DMD) causes progressive pathologic changes to muscle secondary to a cascade of inflammation, lipid deposition, and fibrosis. Clinically, this manifests as progressive weakness, functional loss, and premature mortality. Though insult to whole muscle groups is well established, less is known about the relationship between intramuscular pathology and function. Objective: Differences of intramuscular heterogeneity across muscle length were assessed using an ordinal MRI grading scale in lower leg muscles of boys with DMD and correlated to patient's functional status...
September 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/29774118/proteomic-profiling-of-skeletal-and-cardiac-muscle-in-cancer-cachexia-alterations-in-sarcomeric-and-mitochondrial-protein-expression
#3
Angie M Y Shum, Anne Poljak, Nicholas L Bentley, Nigel Turner, Timothy C Tan, Patsie Polly
Background: Cancer cachexia is observed in more than 50% of advanced cancer patients, and impairs quality of life and prognosis. A variety of pathways are likely to be dysregulated. Hence, a broad-spectrum understanding of the disease process is best achieved by a discovery based approach such as proteomics. Results: More than 300 proteins were identified with > 95% confidence in correct sequence identification, of which 5-10% were significantly differentially expressed in cachectic tissues ( p -value of 0...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29772836/soybean-hop-alleviates-estrogen-deficiency-related-bone-loss-and-metabolic-dysfunction-in-ovariectomized-rats-fed-a-high-fat-diet
#4
Dasom Noh, Yeni Lim, Hansol Lee, Hyejin Kim, Oran Kwon
Soybeans and hops have been traditionally used as a natural estrogen replacement therapy and their major active ingredients, isoflavones and prenylflavanones, are known to have estrogenic/antiestrogenic effects depending on the target organ. However, their potential benefits are still subject to controversies. The present study investigated the dual effect of soy isoflavones plus hop prenylflavanones (Soy-Hop) on bone loss and metabolic dysfunction under estrogen deficient condition. Rats were sham-operated ( n = 10) or ovariectomized (OVX; n = 40) and then fed a high-fat diet (HFD) to develop hyperlipidemia in OVX rats within the experimental period of 8 weeks...
May 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29771823/residual-force-enhancement-is-attenuated-in-a-shortening-magnitude-dependent-manner
#5
Atsuki Fukutani, Walter Herzog
INTRODUCTION: The isometric force attained after active stretch is greater than that attained in a purely isometric contraction. This property is referred to as residual force enhancement (RFE). Although RFE is thought to contribute to the enhanced force and power in stretch-shortening cycles (SSCs), it is unclear whether shortening that occurs after active stretch eliminates the RFE induced by active stretch. Therefore, we evaluated the influence of shortening on RFE. METHODS: Skinned rabbit soleus fibers (N = 43) were used for all tests...
May 16, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29767354/proprioceptive-muscle-tendon-stimulation-reduces-symptoms-in-primary-orthostatic-tremor
#6
M Wuehr, C Schlick, K Möhwald, R Schniepp
INTRODUCTION: Primary orthostatic tremor (OT) is characterized by high-frequency lower limb muscle contractions and a disabling sense of unsteadiness while standing. To date, therapeutic options for OT are limited. Here, we examined the effects of proprioceptive leg muscle stimulation via muscle tendon vibration (MTV) on tremor and balance control in patients with primary OT. METHODS: Tremor in nine patients with primary OT was examined during four conditions: standing (1), standing with MTV on the bilateral soleus muscles (2), lying (3), and lying with MTV (4)...
May 16, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29765493/long-term-exercise-protects-against-cellular-stresses-in-aged-mice
#7
Irina Belaya, Masataka Suwa, Tao Chen, Rashid Giniatullin, Katja M Kanninen, Mustafa Atalay, Shuzo Kumagai
The current study examined the effect of aging and long-term wheel-running on the expression of heat shock protein (HSP), redox regulation, and endoplasmic reticulum (ER) stress markers in tibialis anterior (T.A.) and soleus muscle of mice. Male mice were divided into young (Y, 3-month-old), old-sedentary (OS, 24-month-old), and old-exercise (OE, 24-month-old) groups. The OE group started voluntary wheel-running at 3 months and continued until 24 months of age. Aging was associated with a higher thioredoxin-interacting protein (TxNiP) level, lower thioredoxin-1 (TRX-1) to TxNiP ratio-a determinant of redox regulation and increased CHOP, an indicator of ER stress-related apoptosis signaling in both muscles...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29765188/influence-of-peripheral-magnetic-stimulation-of-soleus-muscle-on-h-and-m-waves
#8
Tadamitsu Matsuda, Taichi Kurayama, Miki Tagami, Yuji Fujino, Atsushi Manji, Yasuaki Kusumoto, Kazu Amimoto
[Purpose] This study evaluated the effects of repetitive peripheral magnetic stimulation of the soleus muscle on spinal cord and peripheral motor nerve excitability. [Subjects and Methods] Twelve healthy adults (mean age 22 years) who provided written informed consent were administered repetitive peripheral magnetic stimulation for 10 min. Pre-and post-stimulation latencies and amplitudes of H- and M-waves of the soleus muscle were measured using electromyography and compared using paired t-tests. [Results] Pre- and post-stimulation latencies (28...
May 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29761850/unexpected-regulation-pattern-of-the-ikk%C3%AE-nf-%C3%AE%C2%BAb-murf1-pathway-with-remarkable-muscle-plasticity-in-the-daurian-ground-squirrel-spermophilus-dauricus
#9
Yanhong Wei, Lingchen Gong, Weiwei Fu, Shenhui Xu, Zhe Wang, Jie Zhang, Er Ning, Hui Chang, Huiping Wang, Yunfang Gao
As a typical hibernator, the Daurian ground squirrel (Spermophilus dauricus) spends considerable time in a state of reduced activity with prolonged fasting. Despite this, they experience little muscle atrophy and have thus become an interesting anti-disuse muscle atrophy model. The IKKβ/NF-κB signaling pathway is significant to muscle atrophy due to the protein degradation resulting from the upregulation of the E3 ubiquitin ligase MuRF1. The current study showed that the IKKβ/NF-κB signaling pathway and MuRF1 maintained relatively steady mRNA and protein expression levels, with little muscle atrophy observed in the soleus (slow-twitch, SOL) or extensor digitorum longus (fast-twitch, EDL) during hibernation (HIB); however, mRNA expression significantly increased in the SOL and EDL muscle during interbout arousal (IBA), as did the MuRF1 mRNA level in the SOL and MuRF1 protein level in the EDL...
May 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29755411/time-of-day-effects-on-metabolic-and-clock-related-adjustments-to-cold
#10
Frederico Sander Mansur Machado, Zhi Zhang, Yan Su, Paul de Goede, Remi Jansen, Ewout Foppen, Cândido Celso Coimbra, Andries Kalsbeek
Background: Daily cyclic changes in environmental conditions are key signals for anticipatory and adaptive adjustments of most living species, including mammals. Lower ambient temperature stimulates the thermogenic activity of brown adipose tissue (BAT) and skeletal muscle. Given that the molecular components of the endogenous biological clock interact with thermal and metabolic mechanisms directly involved in the defense of body temperature, the present study evaluated the differential homeostatic responses to a cold stimulus at distinct time-windows of the light/dark-cycle...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29753766/licorice-flavonoid-oil-enhances-muscle-mass-in-kk-a-y-mice
#11
Yasukiyo Yoshioka, Yoko Yamashita, Hideyuki Kishida, Kaku Nakagawa, Hitoshi Ashida
AIMS: Muscle mass is regulated by the balance between the synthesis and degradation of muscle proteins. Loss of skeletal muscle mass is associated with an increased risk of developing metabolic diseases such as obesity and type 2 diabetes mellitus. The aim of this study was to clarify the effects of licorice flavonoid oil on muscle mass in KK-Ay /Ta mice. MAIN METHODS: Male genetically type II diabetic KK-Ay /Ta mice received 0, 1, or 1.5 g/kg BW of licorice flavonoid oil by mouth once daily for 4 weeks...
May 10, 2018: Life Sciences
https://www.readbyqxmd.com/read/29750000/pathophysiological-analyses-of-skeletal-muscle-in-obese-type-2-diabetes-sdt-fatty-rats
#12
Yusuke Kemmochi, Takeshi Ohta, Yu Motohashi, Akihiro Kaneshige, Sohei Katsumi, Kochi Kakimoto, Yuzo Yasui, Akiko Anagawa-Nakamura, Kaoru Toyoda, Eriko Taniai-Riya, Akemi Takahashi, Toshiyuki Shoda, Takahisa Yamada
Sarcopenia is the age-related decrease of muscle mass and function. Diabetes and obesity are known to be risk factors that exacerbate sarcopenia, but the underlying mechanism of diabetes-related sarcopenia is still unknown. Obese type 2 diabetes SDT fatty rats show early onset of severe diabetes and there have been no reports on the characteristics of their skeletal muscle. Therefore, pathophysiological analyses were performed for the skeletal muscle in these rats. Diabetic male SDT fatty rats were sacrificed at 8, 16, 24, 32 and 40 weeks of age...
April 2018: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29749029/rac1-muscle-knockout-exacerbates-the-detrimental-effect-of-high-fat-diet-on-insulin-stimulated-muscle-glucose-uptake-independently-of-akt
#13
Steffen H Raun, Mona Ali, Rasmus Kjøbsted, Lisbeth L V Møller, Morten A Federspiel, Erik A Richter, Thomas E Jensen, Lykke Sylow
KEY POINTS: The actin cytoskeleton regulating GTPase, Rac1, is a novel player in insulin-stimulated glucose uptake in muscle in vivo. High-fat diet (HFD) exacerbates muscle insulin resistance in Rac1 muscle knockout (mKO) mice. Muscle Rac1 KO protects against HFD-induced insulin resistance in fat tissue indicating tissue cross-talk. A fatty diet markedly reduces insulin clearance in mice. ABSTRACT: Insulin resistance and perturbations in glucose metabolism underpin common lifestyle diseases such as type 2 diabetes and obesity...
May 10, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29739863/effects-of-high-fat-diet-and-ampk-modulation-on-the-regulation-of-whole-body-lipid-metabolism
#14
Milena Schonke, Julie Massart, Juleen R Zierath
Metabolic flexibility, the capacity to adapt to fuel availability for energy production, is crucial for maintaining whole-body energy homeostasis. An inability to adequately promote fatty acid utilization is associated with lipid accumulation in peripheral tissues and contributes to the development of insulin resistance. In vivo assays to quantify whole-body lipid oxidation in mouse models of insulin resistance are lacking. We describe a method for assessing whole-body fatty acid oxidation in vivo , as well as tissue-specific lipid uptake in conscious mice...
May 8, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29738612/evidence-for-a-subcortical-contribution-to-intracortical-facilitation
#15
Patrick Wiegel, Niclas Niemann, John C Rothwell, Christian Leukel
Intracortical facilitation (ICF) describes the facilitation of an EMG response (motor evoked potential) to a suprathreshold pulse (S2) of transcranial magnetic stimulation (TMS) by a preceding subthreshold pulse (S1) given 10 to 15 ms earlier. ICF is widely assumed to originate from intracortical mechanisms. In the present study, we used spinal H-reflexes to test whether subcortical mechanisms can also contribute to the facilitation. Measurements were performed in the upper limb muscle flexor carpi radialis (FCR) in 17 healthy volunteers, and in the lower limb muscle soleus (SOL) in 16 healthy volunteers...
May 8, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29737479/locomotor-treadmill-training-promotes-soleus-trophism-by-mammalian-target-of-rapamycin-pathway-in-paraplegic-rats
#16
Caroline Cunha do Espírito Santo, Daniela Dal Secco, Anamaria Meireles, Gabriel Ribeiro de Freitas, Franciane Bobinski, Mauricio Peña Cunha, Ana Lúcia Severo Rodrigues, Alessandra Swarowsky, Adair Roberto Soares Santos, Jocemar Ilha
Assisted-treadmill training, may be helpful in promoting muscle mass preservation after incomplete spinal cord injury (SCI). However, biological mechanism involved in this process is still not fully understood. This study investigated the effects of locomotor treadmill training on muscle trophism mediated by protein kinase B (Akt)/mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (p70S6K) in paraplegic rats. Adult female Wistar rats underwent an incomplete thoracic SCI induced by compression using an aneurysm clip...
May 8, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29735541/multiplex-quantification-identifies-novel-exercise-regulated-myokines-cytokines-in-plasma-and-in-glycolytic-and-oxidative-skeletal-muscle
#17
Hannah Little, Stefanie Y Tan, Francesca Cali, Susana Rodriguez, Xia Lei, Andrew Wolfe, Christopher Hug, G William Wong
Exercise is known to confer major health benefits, but the underlying mechanisms are not well understood. The systemic effects of exercise on multi-organ systems are thought to be partly due to myokines/cytokines secreted by skeletal muscle. The extent to which exercise alters cytokine expression and secretion in different muscle fiber types has not been systematically examined.  Here, we assessed changes in 66 mouse cytokines in serum, and in glycolytic (plantaris) and oxidative (soleus) muscles, in response to sprint, endurance, or chronic wheel running...
May 7, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29735511/muscle-mri-in-patients-with-dysferlinopathy-pattern-recognition-and-implications-for-clinical-trials
#18
Jordi Diaz-Manera, Roberto Fernandez-Torron, Jaume LLauger, Meredith K James, Anna Mayhew, Fiona E Smith, Ursula R Moore, Andrew M Blamire, Pierre G Carlier, Laura Rufibach, Plavi Mittal, Michelle Eagle, Marni Jacobs, Tim Hodgson, Dorothy Wallace, Louise Ward, Mark Smith, Roberto Stramare, Alessandro Rampado, Noriko Sato, Takeshi Tamaru, Bruce Harwick, Susana Rico Gala, Suna Turk, Eva M Coppenrath, Glenn Foster, David Bendahan, Yann Le Fur, Stanley T Fricke, Hansel Otero, Sheryl L Foster, Anthony Peduto, Anne Marie Sawyer, Heather Hilsden, Hanns Lochmuller, Ulrike Grieben, Simone Spuler, Carolina Tesi Rocha, John W Day, Kristi J Jones, Diana X Bharucha-Goebel, Emmanuelle Salort-Campana, Matthew Harms, Alan Pestronk, Sabine Krause, Olivia Schreiber-Katz, Maggie C Walter, Carmen Paradas, Jean-Yves Hogrel, Tanya Stojkovic, Shin'ichi Takeda, Madoka Mori-Yoshimura, Elena Bravver, Susan Sparks, Luca Bello, Claudio Semplicini, Elena Pegoraro, Jerry R Mendell, Kate Bushby, Volker Straub
BACKGROUND AND OBJECTIVE: Dysferlinopathies are a group of muscle disorders caused by mutations in the DYSF gene. Previous muscle imaging studies describe a selective pattern of muscle involvement in smaller patient cohorts, but a large imaging study across the entire spectrum of the dysferlinopathies had not been performed and previous imaging findings were not correlated with functional tests. METHODS: We present cross-sectional T1-weighted muscle MRI data from 182 patients with genetically confirmed dysferlinopathies...
May 7, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29734063/neuromechanical-adaptations-to-slippery-sport-shoes
#19
Cédric Y M Morio, Alexis Herbaut
Although shoe friction has been widely studied in occupational ergonomics, information was lacking about friction in sport shoes. The purpose of the study was to examine the neuromechanical adaptations to different shoe-surface interface in an aerobic-gym specific movement. Sixteen females performed 10 change of direction movements in two shoe conditions differing by their outsoles (ethyl-vinyl-acetate: EVA and rubber: RB) to ensure significant differences in mechanical coefficients of friction (EVA = 0...
May 4, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29732943/do-changes-in-spinal-reflex-excitability-elicited-by-transcranial-magnetic-stimulation-differ-based-on-the-site-of-cerebellar-stimulation
#20
Akiyoshi Matsugi
PURPOSE: The present study aimed to investigate whether spinal reflex excitability is influenced by the site of cerebellar transcranial magnetic stimulation (C-TMS). MATERIALS AND METHODS: Fourteen healthy volunteers (mean age: 24.6 ± 6.6 years [11 men]) participated. Participants lay on a bed in the prone position, with both ankle joints fixed to prevent unwanted movement. Right tibial nerve stimulation was provided to elicit the H-reflex in the right soleus muscle...
May 6, 2018: Somatosensory & Motor Research
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