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https://www.readbyqxmd.com/read/28433417/mechanistic-insights-into-epigenetic-modulation-of-ethanol-consumption
#1
Igor Ponomarev, Claire E Stelly, Hitoshi Morikawa, Yuri A Blednov, R Dayne Mayfield, R Adron Harris
There is growing evidence that small-molecule inhibitors of epigenetic modulators, such as histone deacetylases (HDAC) and DNA methyltransferases (DNMT), can reduce voluntary ethanol consumption in animal models, but molecular and cellular processes underlying this behavioral effect are poorly understood. We used C57BL/6J male mice to investigate the effects of two FDA-approved drugs, decitabine (a DNMT inhibitor) and SAHA (an HDAC inhibitor), on ethanol consumption using two tests: binge-like drinking in the dark (DID) and chronic intermittent every other day (EOD) drinking...
March 12, 2017: Alcohol
https://www.readbyqxmd.com/read/28431155/motoring-through-the-role-of-kinesin-superfamily-proteins-in-female-meiosis
#2
Nicole J Camlin, Eileen A McLaughlin, Janet E Holt
BACKGROUND: The kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) in both the mitotic and the meiotic cell cycle. Kinesins have important roles in chromosome separation, microtubule dynamics, spindle formation, cytokinesis and cell cycle progression. This article contains a review of the literature with respect to the role of kinesin motor proteins in female meiosis in model species...
April 18, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28431128/binge-drinking-and-well-being-in-european-older-adults-do-gender-and-region-matter
#3
Sonsoles Fuentes, Usama Bilal, Iñaki Galán, Joan R Villalbí, Albert Espelt, Marina Bosque-Prous, Manuel Franco, Mariana Lazo
We aimed to describe gender and region differences in the prevalence of binge drinking and in the association between binge drinking and well-being, among older adult Europeans. This is a cross-sectional study using the Survey of Health, Ageing and Retirement in Europe (SHARE) wave 4, conducted between 2011 and 2012, including 58 489 individuals aged 50 years or older. Sixteen European countries were grouped in four drinking culture regions: South, Central, North and East. We categorized drinking patterns as: never, former, no-binge and binge drinkers...
April 18, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28430930/alcohol-consumption-and-binge-drinking-in-young-men-as-predictors-of-body-composition-changes-during-military-service
#4
Maria P Hagnäs, Jari Jokelainen, Henna Cederberg-Tamminen, Solja Niemelä, Ilona Mikkola, Pirjo Härkönen, Ulla Rajala, Sirkka Keinänen-Kiukaanniemi
Aims: To evaluate the influences of alcohol consumption frequency and binge drinking on changes in the body composition, lifestyle habits and physical fitness of healthy young men during military service. Methods: A population-based study of men performing their military service in the Sodankylä Jaeger Brigade, Finland in 2005. Body composition, fitness and lifestyle habits were evaluated at baseline and 6-12 months follow-up. Alcohol consumption frequency and binge drinking were categorized as: 'not at all', 'at least once a month' and 'at least once a week'...
May 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28430385/significant-reductions-in-alcohol-use-after-hepatitis-c-treatment-results-from-the-french-anrs-co13-hepavih-cohort
#5
Rod Knight, Perrine Roux, Antoine Vilotitch, Fabienne Marcellin, Eric Rosenthal, Laure Esterle, François Boué, David Rey, Lionel Piroth, Stéphanie Dominguez, Philippe Sogni, Dominique Salmon-Ceron, Bruno Spire, Maria Patrizia Carrieri
BACKGROUND AND AIMS: Few data exist on changes to substance use patterns before and after hepatitis C virus (HCV) treatment. We used longitudinal data of HIV-HCV co-infected individuals to examine whether receiving Peg-interferon (Peg-IFN)-based therapy irrespective of HCV clearance could modify tobacco, cannabis and alcohol use. DESIGN: A prospective cohort of HIV-HCV co-infected individuals was enrolled from 2006. Participants' clinical data were retrieved from medical records and socio-demographic and behavioral characteristics were collected by yearly self-administered questionnaires...
April 21, 2017: Addiction
https://www.readbyqxmd.com/read/28426358/effects-of-workplace-generalized-and-sexual-harassment-on-abusive-drinking-among-first-year-male-and-female-college-students-does-prior-drinking-experience-matter
#6
Kathleen M Rospenda, Kaori Fujishiro, Meredith McGinley, Jennifer M Wolff, Judith A Richman
BACKGROUND: Workplace harassment, a known risk factor for adult drinking, is understudied in college samples, but may help explain observed gender differences in drinking patterns. OBJECTIVE: We examine effects of sexual and generalized workplace harassment on changes in drinking behavior over the first semesters of college, and the extent to which these effects differ based on prematriculation drinking for men and women students. METHOD: Data derive from two waves of a longitudinal study of eight Midwestern colleges and universities...
June 7, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28425109/alcoholic-cardiomyopathy-disrupted-protein-balance-and-impaired-cardiomyocyte-contractility
#7
Jennifer L Steiner, Charles H Lang
Alcoholic cardiomyopathy (ACM) can develop after consumption of relatively large amounts of alcohol over time or from acute binge drinking. Of the many factors implicated in the etiology of ACM, chronic perturbation in protein balance has been strongly implicated. This review focuses on recent contributions (since 2010) in the area of protein metabolism and cardiac function related to ACM. Data reviewed include that from in vitro and preclinical in vivo animal studies where alcohol or an oxidative metabolite was studied and outcome measures in either cardiomyocytes or whole heart pertaining to protein synthesis or degradation were reported...
April 20, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28423479/does-a-crossover-age-effect-exist-for-african-american-and-hispanic-binge-drinkers-findings-from-the-2010-to-2013-national-study-on-drug-use-and-health
#8
Tamika C B Zapolski, Patrick Baldwin, Devin E Banks, Timothy E Stump
BACKGROUND: Among general population studies, lower rates of binge drinking tend to be found among African Americans and Hispanics compared to Whites. However, among older adult populations, minority groups have been shown to be at higher risk for binge drinking, suggesting the presence of a crossover effect from low to high risk as a function of age. To date, limited research has examined the crossover effect among African American and Hispanic populations compared to non-Hispanic Whites across large developmental time frames or explored variation in risk based on income or gender...
April 19, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28423476/dietary-patterns-and-alcohol-consumption-during-pregnancy-secondary-analysis-of-avon-longitudinal-study-of-parents-and-children
#9
Victoria Coathup, Kate Northstone, Ron Gray, Simon Wheeler, Lesley Smith
BACKGROUND: Large general population surveys show that heavy regular and episodic alcohol consumption are associated with lower intakes of fruits and vegetables, and higher intakes of processed and fried meat. This is of particular concern regarding pregnant women, as both alcohol intake and inadequate maternal nutrition are independently associated with adverse fetal outcomes. The current study aimed to determine associations between maternal dietary patterns and alcohol consumption during pregnancy...
April 19, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28420969/acquisition-maintenance-and-relapse-like-alcohol-drinking-lessons-from-the-uchb-rat-line
#10
REVIEW
Yedy Israel, Eduardo Karahanian, Fernando Ezquer, Paola Morales, Marcelo Ezquer, Mario Rivera-Meza, Mario Herrera-Marschitz, María E Quintanilla
This review article addresses the biological factors that influence: (i) the acquisition of alcohol intake; (ii) the maintenance of chronic alcohol intake; and (iii) alcohol relapse-like drinking behavior in animals bred for their high-ethanol intake. Data from several rat strains/lines strongly suggest that catalase-mediated brain oxidation of ethanol into acetaldehyde is an absolute requirement (up 80%-95%) for rats to display ethanol's reinforcing effects and to initiate chronic ethanol intake. Acetaldehyde binds non-enzymatically to dopamine forming salsolinol, a compound that is self-administered...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28419776/the-involuntary-nature-of-binge-drinking-goal-directedness-and-awareness-of-intention
#11
Nuria Doñamayor, Daniela Strelchuk, Kwangyeol Baek, Paula Banca, Valerie Voon
Binge drinking represents a public health issue and is a known risk factor in the development of alcohol use disorders. Previous studies have shown behavioural as well as neuroanatomical alterations associated with binge drinking. Here, we address the question of the automaticity or involuntary nature of the behaviour by assessing goal-directed behaviour and intentionality. In this study, we used a computational two-step task, designed to discern between model-based/goal-directed and model-free/habitual behaviours, and the classic Libet clock task, to study intention awareness, in a sample of 31 severe binge drinkers (BD) and 35 matched healthy volunteers...
April 16, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28417252/effects-of-parental-monitoring-and-knowledge-on-substance-use-and-hiv-risk-behaviors-among-young-men-who-have-sex-with-men-results-from-three-studies
#12
Brian Mustanski, Gregory Swann, Michael E Newcomb, Nikhil Prachand
Young men who have sex with men (YMSM) are disproportionately impacted by HIV/AIDS and have elevated rates of substance use. Parenting practices, such as knowledge of child whereabouts and monitoring of behavioral rules, protect against these outcomes among heterosexual youth. This article examined the relationship between these parenting practices and substance use and HIV risk behaviors among YMSM. Data are reported from three similar studies of YMSM: ChiGuys (ages 14-18), Crew 450 (ages 16-22), and RADAR (ages 16-29)...
April 17, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28414474/abstinence-based-incentives-plus-parent-training-for-adolescent-alcohol-and-other-substance-misuse
#13
Catherine Stanger, Emily A Scherer, Steven F Babbin, Stacy R Ryan, Alan J Budney
The purpose of this study was to conduct a randomized test of clinic- and home-based incentives plus parent training for adolescent problem alcohol use. Adolescents (N = 75) with alcohol misuse, with or without other substance misuse, were enrolled. All youth received individual Motivational Enhancement Therapy/Cognitive Behavior Therapy and weekly urine drug testing. The experimental condition (EXP) included Abstinence Incentives (clinic-based incentives for abstinence from all substances) plus weekly behavioral parent training that included a parent-delivered, abstinence-based, substance monitoring contract...
April 17, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28414020/modifying-alcohol-consumption-to-reduce-obesity-macro-development-and-feasibility-trial-of-a-complex-community-based-intervention-for-men
#14
Iain K Crombie, Kathryn B Cunningham, Linda Irvine, Brian Williams, Falko F Sniehotta, John Norrie, Ambrose Melson, Claire Jones, Andrew Briggs, Peter M Rice, Marcus Achison, Andrew McKenzie, Elena Dimova, Peter W Slane
BACKGROUND: Obese men who consume alcohol are at a greatly increased risk of liver disease; those who drink > 14 units of alcohol per week have a 19-fold increased risk of dying from liver disease. OBJECTIVES: To develop an intervention to reduce alcohol consumption in obese men and to assess the feasibility of a randomised controlled trial (RCT) to investigate its effectiveness. DESIGN OF THE INTERVENTION: The intervention was developed using formative research, public involvement and behaviour change theory...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28413697/acute-ethanol-exposure-during-late-mouse-neurodevelopment-results-in-long-term-deficits-in-memory-retrieval-but-not-in-social-responsiveness
#15
Katherine Houlé, Myshake Abdi, Erin B D Clabough
OBJECTIVE: Prenatal alcohol exposure can result in neurological changes in affected individuals and may result in the emergence of a broad spectrum of neurobehavioral abnormalities termed fetal alcohol spectrum disorders (FASD). The effects of ethanol exposure during development are both time and dose dependent. Although many animal models of FASD use more chronic ethanol exposure, acute developmental alcohol exposure may also cause long-lasting neuronal changes. Our research employed behavioral measures to assess the effects of a single early postnatal ethanol intoxication event in mice...
April 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28411560/comparison-between-the-who-and-niaaa-criteria-for-binge-drinking-on-drinking-features-and-alcohol-related-aftermaths-results-from-a-cross-sectional-study-among-eight-emergency-wards-in-france
#16
Benjamin Rolland, Ingrid de Chazeron, Françoise Carpentier, Fares Moustafa, Alain Viallon, Xavier Jacob, Patrick Lesage, Delphine Ragonnet, Annick Genty, Julie Geneste, Emmanuel Poulet, Maurice Dematteis, Pierre-Michel Llorca, Mickaël Naassila, Georges Brousse
BACKGROUND: Binge drinking (BD) consists of heavy episodic alcohol use. Whereas the World Health Organization (WHO) defines BD as 60g of alcohol or more per occasion, the National Institute on Alcoholism and Alcohol Abuse (NIAAA) conceives BD as drinking 70g (men) or 56g (women) in less than two hours. We compared the subjects delineated by each definition. METHODS: Eight-center cross-sectional study among 11,695 subjects hospitalized in emergency wards. Participants completed the Alcohol Use Disorders Identification Test - Consumption (AUDIT-C), CAGE and Rapid Alcohol Problem Screen 4 (RAPS4-QF) questionnaires...
March 23, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28411363/animal-models-of-alcoholic-liver-disease-pathogenesis-and-clinical-relevance
#17
Bin Gao, Ming-Jiang Xu, Adeline Bertola, Hua Wang, Zhou Zhou, Suthat Liangpunsakul
Alcoholic liver disease (ALD), a leading cause of chronic liver injury worldwide, comprises a range of disorders including simple steatosis, steatohepatitis, cirrhosis, and hepatocellular carcinoma. Over the last five decades, many animal models that have been useful for the study of ALD pathogenesis have been developed. Recently, a chronic-plus-binge ethanol feeding model was reported. This model induces significant steatosis, hepatic neutrophil infiltration, and liver injury. A clinically relevant model of high-fat diet feeding plus binge ethanol was also developed, which highlights the risk of excessive binge drinking in obese/overweight individuals...
April 14, 2017: Gene Expression
https://www.readbyqxmd.com/read/28409675/the-relation-between-driving-violations-and-health-promotion-behaviors-among-undergraduate-students-self-report-of-road-behavior
#18
Liat Korn, Yossi Weiss, Tova Rosenbloom
Introduction The purposes of this study are to characterize the Israeli undergraduate students' driving violations in the terms of Problem Behavior Theory and to identify if there is any relationship between driving violations and health risk behaviors, daring behaviors, excitement-seeking, and health promotion behaviors. Methods This study is based on a structured self-reported anonymous questionnaire distributed to undergraduate students in an academic institution. The sample included 533 undergraduate students (374 females and 159 males)...
April 14, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28408897/do-executive-functions-predict-binge-drinking-patterns-evidence-from-a-longitudinal-study-in-young-adulthood
#19
Ragnhild Bø, Joël Billieux, Line C Gjerde, Espen M Eilertsen, Nils I Landrø
Background: Impairments in executive functions (EFs) are related to binge drinking in young adulthood, but research on how EFs influence future binge drinking is lacking. The aim of the current report is therefore to investigate the association between various EFs and later severity of, and change in, binge drinking over a prolonged period during young adulthood. Methods: At baseline, 121 students reported on their alcohol habits (Alcohol use disorder identification test; Alcohol use questionnaire). Concurrently, EFs [working memory, reversal, set-shifting, response inhibition, response monitoring and decision-making (with ambiguity and implicit risk)] were assessed...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28406443/smoke-free-laws-and-hazardous-drinking-a-cross-sectional-study-among-u-s-adults
#20
Nan Jiang, Mariaelena Gonzalez, Pamela M Ling, Kelly C Young-Wolff, Stanton A Glantz
Tobacco and alcohol use are strongly associated. This cross-sectional study examined the relationship of smoke-free law coverage and smoke-free bar law coverage with hazardous drinking behaviors among a representative sample of U.S. adult drinkers (n = 17,057). We merged 2009 National Health Interview Survey data, American Nonsmokers' Rights Foundation U.S. Tobacco Control Laws Database, and Census Population Estimates. Hazardous drinking outcomes included heavy drinking (>14 drinks/week for men; >7 drinks/week for women) and binge drinking (≥5 drinks on one or more days during past year)...
April 13, 2017: International Journal of Environmental Research and Public Health
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