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https://www.readbyqxmd.com/read/28295691/accurate-bond-lengths-to-hydrogen-atoms-from-single-crystal-x-ray-diffraction-by-including-estimated-hydrogen-adps-and-comparison-to-neutron-and-qm-mm-benchmarks
#1
Birger Dittrich, Jens Lübben, Stefan Mebs, Armin Wagner, Peter Luger, Ralf Flaig
Amino acid structures are an ideal test set for method-development studies in crystallography. High-resolution X-ray diffraction data for eight previously studied genetically encoding amino acids are provided, complemented by a non-standard amino acid. Structures were re-investigated to study a widely applicable treatment that permits accurate X-H bond lengths to hydrogen atoms to be obtained: this treatment combines refinement of positional hydrogen-atom parameters with aspherical scattering factors with constrained "TLS+INV" estimated hydrogen anisotropic displacement parameters (H-ADPs)...
March 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28293096/clinical-correlations-of-infliximab-trough-levels-and-antibodies-to-infliximab-in-south-korean-patients-with-crohn-s-disease
#2
Eun Hye Oh, Dae-Hyun Ko, Hyungil Seo, Kiju Chang, Gwang-Un Kim, Eun Mi Song, Myeongsook Seo, Ho-Su Lee, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park
AIM: To investigate the clinical implications of infliximab trough levels (IFX-TLs) and antibodies to infliximab (ATI) levels in Crohn's disease (CD) patients in Asian countries. METHODS: IFX-TL and ATI level were measured using prospectively collected samples obtained with informed consent from CD patients being treated at Asan Medical Center, South Korea. We analyzed the correlations between IFX-TLs/ATI levels and the clinical activity of CD (quiescent vs active disease) based on the CD activity index, C-reactive protein level, and physician's judgment of patients' clinical status at enrollment...
February 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28290677/molecular-insights-into-the-translesion-synthesis-of-benzyl-guanine-from-molecular-dynamics-simulations-structural-evidence-for-mutagenic-and-non-mutagenic-replication
#3
Katie A Wilson, Stacey D Wetmore
DNA can be damaged by many compounds in our environment and the resulting damaged DNA is commonly replicated by translesion synthesis (TLS) polymerases. Since the mechanism and efficiency of TLS is affected by the type of DNA damage, obtaining information for a variety of DNA adducts is critical. However, there is no structural information for the insertion of a dNTP opposite an O6-dG adduct, which is a particularly harmful class of DNA lesions. The current work uses molecular dynamics (MD) simulations to investigate structural and energetic parameters that dictate preferred dNTP insertion opposite O6-benzyl-guanine (Bz-dG) by DNA polymerase IV (Dpo4), a prototypical TLS polymerase...
March 14, 2017: Biochemistry
https://www.readbyqxmd.com/read/28279077/translesion-dna-polymerases-in-eukaryotes-what-makes-them-tick
#4
Alexandra Vaisman, Roger Woodgate
Life as we know it, simply would not exist without DNA replication. All living organisms utilize a complex machinery to duplicate their genomes and the central role in this machinery belongs to replicative DNA polymerases, enzymes that are specifically designed to copy DNA. "Hassle-free" DNA duplication exists only in an ideal world, while in real life, it is constantly threatened by a myriad of diverse challenges. Among the most pressing obstacles that replicative polymerases often cannot overcome by themselves are lesions that distort the structure of DNA...
March 9, 2017: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28276651/realignment-surgery-for-malunited-ankle-fracture
#5
Chang-Jun Guo, Xing-Cheng Li, Mu Hu, Yang Xu, Xiang-Yang Xu
OBJECTIVE: To investigate the characteristics and the results of realignment surgery for the treatment of malunited ankle fracture. METHODS: Thirty-three patients with malunited fractures of the ankle who underwent reconstructive surgery at our hospital from January 2010 to January 2014 were reviewed. The tibial anterior surface angle (TAS), the tibiotalar tilt angle (TTA), the malleolar angle (MA), and the tibial lateral surface angle (TLS) were measured. Clinical assessment was performed with use of the American Orthopaedic Foot and Ankle Society (AOFAS) scale and visual analogue scale (VAS) scores, and the osteoarthritis stage was determined radiographically with the modified Takakura classification system...
March 9, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28273172/altering-the-n-terminal-arms-of-the-polymerase-manager-protein-umud-modulates-protein-interactions
#6
David A Murison, Jaylene N Ollivierre, Qiuying Huang, David E Budil, Penny J Beuning
Escherichia coli cells that are exposed to DNA damaging agents invoke the SOS response that involves expression of the umuD gene products, along with more than 50 other genes. Full-length UmuD is expressed as a 139-amino-acid protein, which eventually cleaves its N-terminal 24 amino acids to form UmuD'. The N-terminal arms of UmuD are dynamic and contain recognition sites for multiple partner proteins. Cleavage of UmuD to UmuD' dramatically affects the function of the protein and activates UmuC for translesion synthesis (TLS) by forming DNA Polymerase V...
2017: PloS One
https://www.readbyqxmd.com/read/28272834/urate-oxidase-for-the-prevention-and-treatment-of-tumour-lysis-syndrome-in-children-with-cancer
#7
REVIEW
Daniel Kl Cheuk, Alan Ks Chiang, Godfrey Cf Chan, Shau Yin Ha
BACKGROUND: Tumour lysis syndrome (TLS) is a serious complication of malignancies and can result in renal failure or death. Previous reviews did not find clear evidence of benefit of urate oxidase in children with cancer. This review is the second update of a previously published Cochrane review. OBJECTIVES: To assess the effects and safety of urate oxidase for the prevention and treatment of TLS in children with malignancies. SEARCH METHODS: In March 2016 we searched CENTRAL, MEDLINE, Embase, and CINAHL...
March 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28258851/longitudinal-2d-strain-can-help-diagnose-coronary-artery-disease-in-patients-with-suspected-non-st-elevation-acute-coronary-syndrome-but-apparent-normal-global-and-segmental-systolic-function
#8
Thibault Caspar, Hafida Samet, Mickaël Ohana, Philippe Germain, Soraya El Ghannudi, Samy Talha, Olivier Morel, Patrick Ohlmann
BACKGROUND: The clinical work-up of patients presenting with chest pain is a diagnostic challenge. We investigated the diagnostic performance of global (GLS) and territorial (TLS) longitudinal strain to predict coronary artery disease (CAD) in patients presenting with suspected non-ST-segment elevation acute coronary syndrome (NSTE-ACS) but apparent normal global and regional systolic function. METHODS: 150 consecutive suspected NSTE-ACS patients were initially screened for inclusion ; 58 patients with normal LVEF (≥55%) and WMSI (=1) were prospectively enrolled...
February 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28238964/pullout-strength-of-a-novel-hybrid-fixation-technique-tape-locking-screw-%C3%A2-in-soft-tissue-acl-reconstruction-a-biomechanical-study-in-human-and-porcine-bone
#9
Mark Ayzenberg, Dillon Arango, Grigory E Gershkovich, Praveen S Samuel, Minn Saing
INTRODUCTION: A novel hybrid anterior cruciate ligament(ACL) reconstruction technique known as Tape Locking Screw™ (TLS)is gaining popularity. Utilizing a suspension-type construct in conjunction with an interference screw,thistechnique has demonstrated successful initial clinical results with the use of quadruple hamstring graft. However, there is currently limited data available on the biomechanical strength of this fixation. This study investigates the pullout strength of theconstructin human distal femora as well as in a porcine model...
February 23, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28237937/investigation-of-viscoelasticity-in-the-relationship-between-carotid-artery-blood-pressure-and-distal-pulse-volume-waveforms
#10
Jong Chan Lee, Zahra Ghasemi, Chang-Sei Kim, Hao-Min Cheng, Chen-Huan Chen, Shih-Hsien Sung, Ramakrishna Mukkamala, Jin-Oh Hahn
We investigated the relationship between carotid artery blood pressure (BP) and distal pulse volume waveforms (PVRs) via subject-specific mathematical modeling. We conceived three physical models to define the relationship: a tube-load model augmented with a gain (TLG), Voigt (TLV) and standard linear solid (TLS) models. We compared these models using PVRs measured via BP cuffs at an upper arm and an ankle as well as carotid artery tonometry waveform collected from 133 subjects. At both upper arm and ankle, PVR was related to carotid artery tonometry by TLV and TLS models better than by TLG model; when root-mean-squared over all the subjects, the systolic and diastolic BP errors between measured carotid artery tonometry waveform and the one estimated from distal PVR reduced from 4...
February 22, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28224765/dysregulation-of-telomere-lengths-and-telomerase-activity-in-myelodysplastic-syndrome
#11
Hee Sue Park, Jungeun Choi, Cha Ja See, Jung Ah Kim, Si Nae Park, Kyongok Im, Sung Min Kim, Dong Soon Lee, Sang Mee Hwang
BACKGROUND: Telomere shortening is thought to be involved in the pathophysiology of myeloid malignancies, but telomere lengths (TL) during interphase and metaphase in hematopoietic malignancies have not been analyzed. We aimed to assess the TLs of interphase and metaphase cells of MDS and telomerase activity (TA) and to find out prognostic significances of TL and TA. METHODS: The prognostic significance of TA by quantitative PCR and TL by quantitative fluorescence in situ hybridization (QFISH) of interphase nuclei and metaphase chromosome arms of bone marrow cells from patients with MDS were evaluated...
May 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28216391/should-hand-assisted-retroperitoneoscopic-nephrectomy-replace-the-standard-laparoscopic-technique-for-living-donor-nephrectomy-a-meta-analysis
#12
REVIEW
Ahmed Elmaraezy, Abdelrahman Ibrahim Abushouk, Moaz Kamel, Ahmed Negida, Omar Naser
OBJECTIVE: We performed this meta-analysis to compare hand-assisted retroperitoneoscopic (HARP) and traditional laparoscopic (TLS) techniques for living donor nephrectomy. METHODS: We searched PubMed, Cochrane Central, EMBASE, and Web of science for prospective studies, comparing HARP and TLS techniques. Data were extracted from eligible studies and pooled as risk ratios (RR) or standardized mean difference (SMD), using RevMan software (version 5.3 for windows)...
February 17, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28214009/trophic-magnification-of-dechlorane-plus-in-the-marine-food-webs-of-fildes-peninsula-in-antarctica
#13
Guangshui Na, Yao Yao, Hui Gao, Ruijing Li, Linke Ge, Ivan A Titaley, Lisandra Santiago-Delgado, Staci L Massey Simonich
The food web composition, assimilation efficiency of Dechlorane Plus (DP) in food web components, and even extrinsic conditions can affect the trophic biomagnification potentials of DP isomers in food webs. Antarctica ecological system is characterized by the presence of few consumers and simple trophic levels (TLs), which are crucial in discussing the behavior of contaminants. To assess the biomagnification potential of DP in the Antarctic food web, nine representative species were sampled and analyzed from the Fildes Peninsula...
February 14, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28208741/mechanisms-of-post-replication-dna-repair
#14
REVIEW
Yanzhe Gao, Elizabeth Mutter-Rottmayer, Anastasia Zlatanou, Cyrus Vaziri, Yang Yang
Accurate DNA replication is crucial for cell survival and the maintenance of genome stability. Cells have developed mechanisms to cope with the frequent genotoxic injuries that arise from both endogenous and environmental sources. Lesions encountered during DNA replication are often tolerated by post-replication repair mechanisms that prevent replication fork collapse and avert the formation of DNA double strand breaks. There are two predominant post-replication repair pathways, trans-lesion synthesis (TLS) and template switching (TS)...
February 8, 2017: Genes
https://www.readbyqxmd.com/read/28203093/prevention-and-treatment-of-tumor-lysis-syndrome-and-the-efficacy-and-role-of-rasburicase
#15
REVIEW
Nael Alakel, Jan Moritz Middeke, Johannes Schetelig, Martin Bornhäuser
Tumor lysis syndrome (TLS) is a potentially life-threatening condition that occurs in oncologic and hematologic patients with large tumor burden, either due to cytotoxic therapy or, less commonly, spontaneously because of massive tumor cell lysis. TLS is clinically characterized by acute renal failure, hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. While limited options are available for treating TLS, identifying patients at high risk for developing TLS and prevention in high-risk patients remain an important aspect in the treatment of cancer patients...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28197375/tumor-infiltrating-lymphocyte-composition-organization-and-pd-1-pd-l1-expression-are-linked-in-breast-cancer
#16
Laurence Buisseret, Soizic Garaud, Alexandre de Wind, Gert Van den Eynden, Anais Boisson, Cinzia Solinas, Chunyan Gu-Trantien, Céline Naveaux, Jean-Nicolas Lodewyckx, Hugues Duvillier, Ligia Craciun, Isabelle Veys, Denis Larsimont, Martine Piccart-Gebhart, John Stagg, Christos Sotiriou, Karen Willard-Gallo
The clinical relevance of tumor-infiltrating lymphocytes (TIL) in breast cancer (BC) has been clearly established by their demonstrated correlation with long-term positive outcomes. Nevertheless, the relationship between protective immunity, observed in some patients, and critical features of the infiltrate remains unresolved. This study examined TIL density, composition and organization together with PD-1 and PD-L1 expression in freshly collected and paraffin-embedded tissues from 125 patients with invasive primary BC...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28194054/tumor-lysis-syndrome-in-multiple-myeloma-an-increasingly-recognized-risk-a-report-of-seven-cases
#17
Abhijai Singh, Shweta Gupta, Barbara Yim, Romy Thekkekara
Tumor lysis syndrome is a constellation of metabolic disturbances commonly seen during therapy of bulky, rapidly proliferative tumors. Multiple myeloma is a low proliferation tumor with rare incidence of tumor lysis syndrome in the pre-Bortezomib era. Post Bortezomib use, a rise in the incidence of tumor lysis has been noted. We present seven cases of tumor lysis syndrome with three patients in spontaneous tumor lysis and four developing the same after chemotherapy. In the previous studies, elevated LDH and deletion of chromosome 13 has been associated with risk of TLS...
March 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28193140/short-term-clinico-radiological-outcome-of-chronic-knee-synovitis-among-haemophilia-a-patients-post-phosphorus-32-radiosynoviorthesis
#18
Prasanna Ty, Jagadish Menon, Nataraj Ar, Dhanapathi Halanaik, Harshith Kramadhari
PURPOSE: Various modes of therapy have been directed at breaking the vicious cycle at early stage of synovitis in haemophilia patients. This study was planned to assess the short-term clinico-radiological outcome of chronic knee synovitis among haemophilia A patients post phosphorus-32 (P-32) radiosynoviorthesis. METHODS: P-32 samarium radiocolloid was injected into the knee and patients were followed up at 1 and 3 months, respectively. Clinical outcomes was assessed using Tegner Lysholm scores (TLSs), Modified Knee Society Clinical Rating System (MKSS) score and circumference of the knee joint...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28192118/prg4-expression-in-myxoid-liposarcoma-maintains-tumor-cell-growth-through-suppression-of-an-antitumor-cytokine-il-24
#19
Kosuke Oikawa, Anna Mizusaki, Masakatsu Takanashi, Takashi Ozaki, Fuyuki Sato, Masahiko Kuroda, Yasuteru Muragaki
PRG4 is one of the downstream molecules of the myxoid liposarcoma (MLS)-specific fusion oncoproteins TLS-CHOP and EWS-CHOP. Exogenous PRG4 expression increases the tumorigenicity of cells injected in nude mice. The molecular functions of PRG4 in tumorigenesis and/or tumor progression of MLS cells, however, still remain unclear. In this report, we demonstrated that siRNA-mediated knockdown of PRG4 suppressed the growth of the MLS-derived cell lines 1955/91 and 2645/94. In addition, PRG4 knockdown promoted adipocytic differentiation in 1955/91 cells...
March 25, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28184985/the-effects-of-threshing-and-redrying-on-bacterial-communities-that-inhabit-the-surface-of-tobacco-leaves
#20
Jianbin Ye, Ji Yan, Zhan Zhang, Zongcan Yang, Xiangzhen Liu, Hao Zhou, Genfa Wang, Hui Hao, Ke Ma, Yuping Ma, Duobin Mao, Xuepeng Yang
Before being subjected to the aging process, raw tobacco leaves (TLs) must be threshed and redried. We propose that threshing and redrying affect the bacterial communities that inhabit the TL surface, thereby influencing the aging process. However, these effects remain unclear. In this study, Illumina sequencing was applied to analyze the bacterial communities on both raw and redried TLs. Shannon's diversity value decreased from 3.38 to 2.52 after the threshing and redrying processes, indicating a large reduction in TL bacterial diversity...
February 9, 2017: Applied Microbiology and Biotechnology
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