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https://www.readbyqxmd.com/read/27919998/high-risk-of-tumor-lysis-syndrome-in-symptomatic-patients-with-multiple-myeloma-with-renal-dysfunction-treated-with-bortezomib
#1
Kana Oiwa, Mihoko Morita, Shinji Kishi, Miyuki Okura, Toshiki Tasaki, Yasufumi Matsuda, Katsunori Tai, Naoko Hosono, Takanori Ueda, Takahiro Yamauchi
BACKGROUND/AIM: Tumor lysis syndrome (TLS) is a life-threatening complication associated with cancer chemotherapy. We retrospectively evaluated the risk of developing TLS in patients with symptomatic multiple myeloma undergoing chemotherapy. PATIENTS AND METHODS: Sixty-four patients (median age=71 years, range=48-87 years, 35 males/29 females) who were treated at our Institution between April 2006 and December 2015 were evaluated. RESULTS: A total of 124 chemotherapy courses were administered, of which 63 courses were bortezomib-based regimens and 34 courses were immunomodulatory drug (IMiD)-based regimens...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27916374/transfer-and-priming-of-surgical-skills-across-minimally-invasive-surgical-platforms
#2
Ahmed Zihni, Tianjia Ge, Shuddhadeb Ray, Robert Wang, Zhe Liang, Jaime A Cavallo, Michael M Awad
BACKGROUND: Robot-assisted laparoscopic surgery (RALS) uses 3-dimensional visualization and wristed instruments that provide more degrees of freedom than rigid traditional laparoscopic (TLS) instrumentation. These features have been touted to improve accuracy and efficiency during surgical task performance. Little is known, however, about the transferability of skills between the two platforms or whether task performance on one platform primes surgeons for task performance on the other...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27915231/predominant-role-of-dna-polymerase-eta-and-p53-dependent-translesion-synthesis-in-the-survival-of-ultraviolet-irradiated-human-cells
#3
Leticia K Lerner, Guilherme Francisco, Daniela T Soltys, Clarissa R R Rocha, Annabel Quinet, Alexandre T Vessoni, Ligia P Castro, Taynah I P David, Silvina O Bustos, Bryan E Strauss, Vanesa Gottifredi, Anne Stary, Alain Sarasin, Roger Chammas, Carlos F M Menck
Genome lesions trigger biological responses that help cells manage damaged DNA, improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses lesions that block replicative polymerases, avoiding continued stalling of replication forks, which could lead to cell death. p53 also plays an important role in preventing cell death after ultraviolet (UV) light exposure. Intriguingly, we show that p53 does so by favoring translesion DNA synthesis by pol eta. In fact, the p53-dependent induction of pol eta in normal and DNA repair-deficient XP-C human cells after UV exposure has a protective effect on cell survival after challenging UV exposures, which was absent in p53- and Pol H-silenced cells...
December 2, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27912025/population-dynamics-synchrony-and-environmental-quality-of-hokkaido-voles-lead-to-temporal-and-spatial-taylor-s-laws
#4
Joel E Cohen, Takashi Saitoh
Taylor's law (TL) asserts that the variance in a species' population density is a power-law function of its mean population density: log(variance) = a + b × log(mean). TL is widely verified. We show here that empirical time series of density of the Hokkaido gray-sided vole, Myodes rufocanus, sampled 1962-1992 at 85 locations, satisfied temporal and spatial forms of TL. The slopes (b ± standard error) of the temporal and spatial TL were estimated to be 1.613 ± 0.141 and 1.430 ± 0.132, respectively...
December 2016: Ecology
https://www.readbyqxmd.com/read/27910741/topotecan-liposomes-a-visit-from-a-molecular-to-a-therapeutic-platform
#5
Shivani Saraf, Ankit Jain, Pooja Hurkat, Sanjay Kumar Jain
Topotecan (TPT), a potent anticancer camptothecin analog, is well described for the treatment of ovarian cancer, but has also anticancer activity against small-cell and non-small-cell lung cancer, breast cancer, and acute leukemia. Various nanocarriers, including liposomes, have been exploited for targeted delivery of TPT. However, there are a number of challenges with TPT delivery using TPT liposomes (TLs), such as low encapsulation efficiency, physiological pH labile E ring (hydrolysis), accelerated blood clearance, multidrug resistance, and cancer metastases...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/27896146/determination-of-functional-prognosis-in-hospitalized-patients-following-an-intensive-care-admission
#6
Natália A Ferreira, Agnaldo José Lopes, Arthur S Ferreira, George Ntoumenopoulos, Jerffesson Dias, Fernando S Guimaraes
AIM: To investigate the factors associated with the functional progress of hospitalized patients following an intensive care admission. METHODS: Retrospective study including data from a cohort of 198 hospitalized patients following an intensive care admission and not requiring mechanical ventilation in a single tertiary referral hospital. A generalized linear model was used to identify the main effects of clinical and demographic variables on the outcomes of functionality (KATZ Index of Independence in Activities of Daily Living) and muscle strength (MRC Scale)...
November 4, 2016: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27890986/correlation-of-chest-computed-tomography-findings-with-dyspnea-and-lung-functions-in-post-tubercular-sequelae
#7
Ananya Panda, Ashu Seith Bhalla, Raju Sharma, Anant Mohan, Vishnu Sreenivas, Umasankar Kalaimannan, Ashish Dutt Upadhyay
AIMS: To study the correlation between dyspnea, radiological findings, and pulmonary function tests (PFTs) in patients with sequelae of pulmonary tuberculosis (TB). MATERIALS AND METHODS: Clinical history, chest computed tomography (CT), and PFT of patients with post-TB sequelae were recorded. Dyspnea was graded according to the Modified Medical Research Council (mMRC) scale. CT scans were analyzed for fibrosis, cavitation, bronchiectasis, consolidation, nodules, and aspergilloma...
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27888526/the-optimal-single-dose-regimen-of-rasburicase-for-management-of-tumour-lysis-syndrome-in-children-and-adults-a-systematic-review-and-meta-analysis
#8
REVIEW
X Yu, L Liu, X Nie, J Li, J Zhang, L Zhao, X Wang
WHAT IS KNOWN AND OBJECTIVE: To perform a meta-analysis exploring the optimal single-dose regimen for managing tumour lysis syndrome (TLS) in children and adults with haematological malignancies. METHODS: We systematically searched PubMed, MEDLINE, Web of Science, the Cochrane Library and the ClinicalTrials.gov website for studies regarding single-dose rasburicase in paediatric and adult patients with TLS. Data were analysed using Open MetaAnalyst statistical software...
November 25, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27884061/embryos-cultured-in-a-time-lapse-system-result-in-superior-treatment-outcomes-a-strict-matched-pair-analysis
#9
Amy Barrie, Roy Homburg, Garry McDowell, Jeremy Brown, Charles Kingsland, Stephen Troup
A retrospective strict matched-pair analysis of 728 treatment cycles between January 2011 and September 2014 was performed. A total of 364 treatment cycles, where all embryos were cultured and examined in EmbryoScope(®), were matched to treatment cycles where all the embryos were cultured in a standard incubator with conventional morphological examination. Matching was performed for patient age, number of oocytes collected, treatment type and date of oocyte collection (± six months). The clinical (CPR), implantation (IR), live birth (LBR) and miscarriage rates (MR) were calculated and considered significant when p < 0...
November 24, 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27877173/stromal-fibroblasts-in-tertiary-lymphoid-structures-a-novel-target-in-chronic-inflammation
#10
REVIEW
Francesca Barone, David H Gardner, Saba Nayar, Nathalie Steinthal, Christopher D Buckley, Sanjiv A Luther
Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid, and stromal cells that provide ectopic hubs for acquired immune responses. TLS share phenotypical and functional features with secondary lymphoid organs (SLO); however, they require persistent inflammatory signals to arise and are often observed at target sites of autoimmune disease, chronic infection, cancer, and organ transplantation. Over the past 10 years, important progress has been made in our understanding of the role of stromal fibroblasts in SLO development, organization, and function...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27874290/impact-of-clinical-factors-on-outcome-of-leukemia-patients-with-tls-erg-fusion-gene
#11
Jing Pan, Yang Zhang, Yan-Li Zhao, Jun-Fang Yang, Jian-Ping Zhang, Hong-Xing Liu, Tong Wu, Chun-Rong Tong
We report the clinical features and outcome of 22 TLS-ERG(+ )leukemia patients (20 AML and 2 B-ALL). TLS-ERG was tightly associated with extramedullary disease (EMD), complex chromosome abnormalities, and high risk gene mutations including IKZF1, WT1, TET2, NOTCH2, and PHF6. The 6-month leukemia free survival (LFS) with and without EMD was 75% and 83.3% (p = .017). 11/20 AML patients received allogeneic hematopoietic stem cell transplantation (HCT). The 1-year overall survival (OS) in non-HCT and HCT group was 62...
November 22, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27862447/minor-groove-3-deaza-adenosine-analogs-synthesis-and-bypass-in-translesion-dna-synthesis
#12
Stefano Malvezzi, Todor Angelov, Shana Jocette Sturla
Anticancer drugs that alkylate DNA in the minor groove may give rise to 3-alkyl-adenosine adducts that interfere with replication, inducing apoptosis in rapidly dividing cancer cells. However, translesion DNA synthesis (TLS) by polymerase enzymes (Pols) with the capacity to bypass DNA adducts may contribute to damage tolerance and drug resistance. 3-Alkyl-adenosine adducts are unstable and depurinate, a barrier to addressing chemical and enzymatic aspects of how they impact the progress of DNA Pols. To characterize structure-based relationships of 3-adenine alkylation relevant to cancer drugs on duplex stability and DNA Pol-catalyzed DNA synthesis, we synthesized stable 3-deaza-3-alkyl-adenosine adducts, including 3-deaza-3-phenethyl-adenosine and 3-deaza-3-methoxynaphthylethyl-adenosine, and incorporated them into oligonucleotides...
November 10, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27829156/proteomic-profiling-reveals-a-specific-role-for-translesion-dna-polymerase-%C3%AE-in-the-alternative-lengthening-of-telomeres
#13
Laura Garcia-Exposito, Elodie Bournique, Valérie Bergoglio, Arindam Bose, Jonathan Barroso-Gonzalez, Sufang Zhang, Justin L Roncaioli, Marietta Lee, Callen T Wallace, Simon C Watkins, Patricia L Opresko, Jean-Sébastien Hoffmann, Roderick J O'Sullivan
Cancer cells rely on the activation of telomerase or the alternative lengthening of telomeres (ALT) pathways for telomere maintenance and survival. ALT involves homologous recombination (HR)-dependent exchange and/or HR-associated synthesis of telomeric DNA. Utilizing proximity-dependent biotinylation (BioID), we sought to determine the proteome of telomeres in cancer cells that employ these distinct telomere elongation mechanisms. Our analysis reveals that multiple DNA repair networks converge at ALT telomeres...
November 8, 2016: Cell Reports
https://www.readbyqxmd.com/read/27828609/mind-the-gap-implementation-challenges-break-the-link-between-hiv-aids-research-and-practice
#14
Sarah MacCarthy, Sari Reisner, Michael Hoffmann, Amaya Perez-Brumer, Alfonso Silva-Santisteban, Amy Nunn, Leonardo Bastos, Mauricio Teixeira Leite de Vasconcellos, Ligia Kerr, Francisco Inácio Bastos, Inês Dourado
Sampling strategies such as respondent-driven sampling (RDS) and time-location sampling (TLS) offer unique opportunities to access key populations such as men who have sex with men (MSM) and transgender women. Limited work has assessed implementation challenges of these methods. Overcoming implementation challenges can improve research quality and increase uptake of HIV services among key populations. Drawing from studies using RDS in Brazil and TLS in Peru, we summarize challenges encountered in the field and potential strategies to address them...
November 3, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27828490/theory-for-voltage-modulation-of-transistor-lasers-using-franz-keldysh-absorption-in-the-presence-of-optoelectronic-feedback
#15
Chi-Hsiang Chang, Shu-Wei Chang, Chao-Hsin Wu
Compared with typical diode lasers (DLs), transistor lasers (TLs) support not only current-controlled but also voltage-controlled modulation. In this work, we theoretically investigate the small-signal voltage modulation of TLs based on the Franz-Keldysh (F-K) absorption and related optoelectronic feedback. In addition to the conventional rate equations relevant to DLs, our model physically includes various F-K effects. An optically induced current due to the F-K absorption may dramatically alter the voltage response of TLs...
October 31, 2016: Optics Express
https://www.readbyqxmd.com/read/27828363/modeling-hemispherical-reflectance-for-natural-surfaces-based-on-terrestrial-laser-scanning-backscattered-intensity-data
#16
Kai Tan, Xiaojun Cheng, Xiaolong Cheng
Independent of instrumental properties and scanning geometry, target reflectance is significantly important for terrestrial laser scanning (TLS) data processing and utilization, especially in multi-temporal and multi-sensor cases. In addition to the 3D topographic coordinates, TLS systems also record the backscattered intensity value of each point that provides additional information on the reflectance characteristics of the scanned surface. However, a number of confounding variables, particularly the distance and incidence angle, distort the ability of the original intensity to directly retrieve the target reflectance...
October 3, 2016: Optics Express
https://www.readbyqxmd.com/read/27818323/als-causing-mutations-differentially-affect-pgc-1%C3%AE-expression-and-function-in-the-brain-vs-peripheral-tissues
#17
Hanna Bayer, Kerstin Lang, Eva Buck, Julia Higelin, Lara Barteczko, Noemi Pasquarelli, Jasmin Sprissler, Tanja Lucas, Karlheinz Holzmann, Maria Demestre, Katrin S Lindenberg, Karin M Danzer, Tobias Boeckers, Albert C Ludolph, Luc Dupuis, Patrick Weydt, Anke Witting
BACKGROUND: Monogenetic forms of amyotrophic lateral sclerosis (ALS) offer an opportunity for unraveling the molecular mechanisms underlying this devastating neurodegenerative disorder. In order to identify a link between ALS-related metabolic changes and neurodegeneration, we investigated whether ALS-causing mutations interfere with the peripheral and brain-specific expression and signaling of the metabolic master regulator PGC (PPAR gamma coactivator)-1α (PGC-1α). METHODS: We analyzed the expression of PGC-1α isoforms and target genes in two mouse models of familial ALS and validated the stimulated PGC-1α signaling in primary adipocytes and neurons of these animal models and in iPS derived motoneurons of two ALS patients harboring two different frame-shift FUS/TLS mutations...
November 3, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27816725/blinatumomab-provoked-fatal-heart-failure
#18
REVIEW
Behrad Darvishi, Leila Farahmand, Neda Jalili, Keivan Majidzadeh-A
Mentioned in Blinatumomab (Blincyto®) clinical safety report, a 5 year old boy with acute lymphoblastic leukemia (ALL) receiving Blincyto® with the concentration of 30μg/m(2)/day on the fourth day of therapy developed both Cytokine Release Syndrome (CRS) and Tumor Lysis Syndrome (TLS). Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Bilirubin peaks were 18, 7 and 8 folds more than upper normal limit (UNL) respectively. However, albumin was reduced to approximately half of the lower Normal limit (LNL)...
December 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27799872/potential-of-cells-and-cytokines-chemokines-to-regulate-tertiary-lymphoid-structures-in-human-diseases
#19
REVIEW
Feifeng Jing, Eun Young Choi
Tertiary lymphoid structures (TLS) are ectopic lymphoid tissues involved in chronic inflammation, autoimmune diseases, transplant rejection and cancer. They exhibit almost all the characteristics of secondary lymphoid organs (SLO), which are associated with adaptive immune responses; as such, they contain organized B-cell follicles with germinal centers, distinct areas containing T cells and dendritic cells, high endothelial venules, and lymphatics. In this review, we briefly describe the formation of SLO, and describe the cellular subsets and molecular cues involved in the formation and maintenance of TLS...
October 2016: Immune Network
https://www.readbyqxmd.com/read/27796404/-x%C3%A2-ray-of-the-thoracic-and-lumbar-spine-in-injured-children-and-adolescents-incidence-fracture-rates-and-therapeutic-consequences
#20
T Ruffing, M Wiehmann, H Winkler, M Muhm
INTRODUCTION: Usually, conventional radiographs are appropriate for injuries in the region of the thoracic and lumbar spine (TLS) in children and adolescents. The aim of our study was to determine the incidence of trauma-associated radiographic findings in this anatomical region and to present the therapeutic consequences. MATERIAL AND METHODS: In a retrospective cohort study (2007-2015) of a level 1 trauma center all children and adolescents (0-17 years) with a TLS-trauma, in which conventional radiographs were performed anteroposterior and lateral as the initial imaging modality, were included...
October 28, 2016: Der Unfallchirurg
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