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https://www.readbyqxmd.com/read/29773833/transcriptome-and-mirna-analyses-of-the-response-to-corynespora-cassiicola-in-cucumber
#1
Xiangyu Wang, Di Zhang, Na Cui, Yang Yu, Guangchao Yu, Haiyan Fan
Cucumber (Cucumis sativus L.) target leaf spot (TLS), which is caused by the fungus Corynespora cassiicola (C. cassiicola), seriously endangers the production of cucumber. In this assay, we performed comprehensive sequencing of the transcriptome and microRNAs (miRNAs) of a resistant cucumber (Jinyou 38) during C. cassiicola inoculation using the Illumina NextSeq 500 platform. The possible genes related to the response to C. cassiicola were associated with plant hormones, transcription factors, primary metabolism, Ca2+ signaling pathways, secondary metabolism and defense genes...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29757988/a-lightweight-protocol-for-secure-video-streaming
#2
Algimantas Venčkauskas, Nerijus Morkevicius, Kazimieras Bagdonas, Robertas Damaševičius, Rytis Maskeliūnas
The Internet of Things (IoT) introduces many new challenges which cannot be solved using traditional cloud and host computing models. A new architecture known as fog computing is emerging to address these technological and security gaps. Traditional security paradigms focused on providing perimeter-based protections and client/server point to point protocols (e.g., Transport Layer Security (TLS)) are no longer the best choices for addressing new security challenges in fog computing end devices, where energy and computational resources are limited...
May 14, 2018: Sensors
https://www.readbyqxmd.com/read/29749403/obinutuzumab-plus-bendamustine-in-previously-untreated-patients-with-cll-a-subgroup-analysis-of-the-green-study
#3
Stephan Stilgenbauer, Veronique Leblond, Robin Foà, Sebastian Böttcher, Osman Ilhan, Wolfgang Knauf, Eva Mikuskova, Christoph Renner, Eugen Tausch, Dariusz Woszczyk, Ekaterina Gresko, Linda Lundberg, Tom Moore, Thea Morris, Susan Robson, Francesc Bosch
GREEN (NCT01905943) is a non-randomized, open-label phase IIIb study investigating obinutuzumab alone or plus chemotherapy in chronic lymphocytic leukemia (CLL). We report a preplanned subgroup analysis of 158 previously untreated CLL patients receiving obinutuzumab-bendamustine (G-B). Patients received six 28-day cycles (C) of G-B: obinutuzumab day (D)1/D2 of C1 (25 mg D1/975 mg D2), 1000 mg D8 and D15 of C1, and D1 of C2-6; and bendamustine 70/90 mg/m2 D1 and D2 of C1-6. The primary endpoint was safety/tolerability...
April 27, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29727925/effect-of-the-construction-of-ski-runs-on-changes-in-relief-in-a-mountain-catchment-inner-carpathians-southern-poland
#4
Joanna Fidelus-Orzechowska, Dominika Wrońska-Wałach, Jarosław Cebulski, Mirosław Żelazny
In the last decade increasing popularity of winter tourism in mountain areas in Poland influenced development of ski infrastructure. This type of human activity may induce changes in mountain relief. The purpose of the study was to quantify ongoing change patterns via: (i) a determination of spatial and quantitative changes in catchment covered by new ski runs, (ii) a determination of the effect of new ski runs on the rejuvenation of relief in valleys adjacent to ski runs, (iii) an identification of changes in the surface runoff pattern before and after the construction of ski runs...
July 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29721382/expression-of-llt1-and-its-receptor-cd161-in-lung-cancer-is-associated-with-better-clinical-outcome
#5
Véronique M Braud, Jérôme Biton, Etienne Becht, Samantha Knockaert, Audrey Mansuet-Lupo, Estelle Cosson, Diane Damotte, Marco Alifano, Pierre Validire, Fabienne Anjuère, Isabelle Cremer, Nicolas Girard, Dominique Gossot, Agathe Seguin-Givelet, Marie-Caroline Dieu-Nosjean, Claire Germain
Co-stimulatory and inhibitory receptors expressed by immune cells in the tumor microenvironment modulate the immune response and cancer progression. Their expression and regulation are still not fully characterized and a better understanding of these mechanisms is needed to improve current immunotherapies. Our previous work has identified a novel ligand/receptor pair, LLT1/CD161, that modulates immune responses. Here, we extensively characterize its expression in non-small cell lung cancer (NSCLC). We show that LLT1 expression is restricted to germinal center (GC) B cells within tertiary lymphoid structures (TLS), representing a new hallmark of the presence of active TLS in the tumor microenvironment...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29708067/polymerase-delta-in-eukaryotes-how-is-it-transiently-exchanged-with-specialized-dna-polymerases-during-translesion-dna-synthesis
#6
Fengyu Liu, Yulong Yang, Yajing Zhou
Precise duplication of the human genome is constantly threatened by a variety of genotoxic insults. During S-phase, those damaged template bases could be overcome by DNA damage tolerance (DDT) pathways that bypass such obstacles instead of repairing them, allowing replicative machinery to resume beyond the offending lesions. Two distinct strategies of DDT, template switching and translesion DNA synthesis (TLS), are employed in eukaryotes. In the former process, the newly synthesized sister chromatid is utilized as an undamaged template to restart recombination-dependent DNA synthesis in an error-free manner...
April 30, 2018: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29704992/opposing-roles-of-y-family-dna-polymerases-in-lipid-peroxide-mutagenesis-at-the-hisg46-target-in-the-ames-test
#7
Petr Grúz, Masatomi Shimizu, Masami Yamada, Kei-Ichi Sugiyama, Masamitsu Honma
DNA polymerases play a key role in mutagenesis by performing translesion DNA synthesis (TLS). The Y-family of DNA polymerases comprises several evolutionarily conserved families, specializing in TLS of different DNA adducts. Exocyclic etheno and propano DNA adducts are among the most common endogenous DNA lesions induced by lipid peroxidation reactions triggered by oxidative stress. We have investigated the participation of two enterobacterial representatives of the PolIV and PolV branches of Y-family DNA polymerases in mutagenesis by two model lipid peroxidation derived genotoxins, glyoxal and crotonaldehyde...
May 2018: Mutation Research
https://www.readbyqxmd.com/read/29700578/specialised-dna-polymerases-in-escherichia-coli-roles-within-multiple-pathways
#8
REVIEW
Sarah S Henrikus, Antoine M van Oijen, Andrew Robinson
In many bacterial species, DNA damage triggers the SOS response; a pathway that regulates the production of DNA repair and damage tolerance proteins, including error-prone DNA polymerases. These specialised polymerases are capable of bypassing lesions in the template DNA, a process known as translesion synthesis (TLS). Specificity for lesion types varies considerably between the different types of TLS polymerases. TLS polymerases are mainly described as working in the context of replisomes that are stalled at lesions or in lesion-containing gaps left behind the replisome...
April 26, 2018: Current Genetics
https://www.readbyqxmd.com/read/29697100/the-comparative-effect-of-wrapping-solid-gold-nanoparticles-and-hollow-gold-nanoparticles-with-doxorubicin-loaded-thermosensitive-liposomes-for-cancer-thermo-chemotherapy
#9
Yanan Li, Dongsheng He, Jiasheng Tu, Ru Wang, Chang Zu, You Chen, Wenqian Yang, Di Shi, Thomas J Webster, Yan Shen
Since conventional chemotherapy is a systemic treatment that affects the body globally and will not concentrate inside the tumor, it causes adverse side effects to patients. In this study, doxorubicin (DOX) together with solid gold nanoparticles (GNPs) or hollow gold nanoparticles (HGNPs), respectively, is loaded inside thermosensitive liposomes (GNPs&DOX-TLs and HGNPs&DOX-TLs), where the GNPs and HGNPs act as a "nanoswitch" for killing tumor cells directly by hyperthermia and triggering DOX release from TLs in the tumor quickly by near infrared laser (NIR) illumination...
April 26, 2018: Nanoscale
https://www.readbyqxmd.com/read/29685891/cytotoxic-and-mutagenic-properties-of-minor-groove-o-2-alkylthymidine-lesions-in-human-cells
#10
Jun Wu, Pengcheng Wang, Lin Li, Changjun You, Yinsheng Wang
Endogenous metabolism, environmental exposure, and cancer chemotherapy can lead to alkylation of DNA. It has been well documented that, among the different DNA alkylation products, minor-groove O 2 -alkylthymidine ( O 2 -alkyldT) lesions are inefficiently repaired. In the present study, we examined how seven O 2 -alkyldT lesions, with the alkyl group being a Me, Et, n Pr, i Pr, n Bu, i Bu or s Bu, are recognized by the DNA replication machinery in human cells. We found that the replication bypass efficiencies of these lesions decrease with increasing length of the alkyl chain, and that these lesions induce substantial frequencies of T→A and T→G mutations...
April 23, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29683915/organized-chaos-in-late-specialization-team-sports-weekly-training-loads-of-elite-adolescent-rugby-union-players
#11
Padraic J Phibbs, Ben Jones, Gregory Roe, Dale B Read, Joshua Darrall-Jones, Jonathon Weakley, Andrew Rock, Kevin Till
Phibbs, PJ, Jones, B, Roe, G, Read, DB, Darrall-Jones, J, Weakley, J, Rock, A, and Till, K. Organized chaos in late specialization team sports: weekly training loads of elite adolescent rugby union players. J Strength Cond Res 32(5): 1316-1323, 2018-The aim of this study was to quantify the mean weekly training load (TL) of elite adolescent rugby union players participating in multiple teams and examine the differences between playing positions. Twenty elite male adolescent rugby union players (17.4 ± 0.7 years) were recruited from a regional academy and categorized by playing position: forwards (n = 10) and backs (n = 10)...
May 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29683380/diverse-roles-of-rad18-and-y-family-dna-polymerases-in-tumorigenesis
#12
Yang Yang, Yanzhe Gao, Anastasia Zlatanou, Satoshi Tateishi, Vyacheslav Yurchenko, Igor B Rogozin, Cyrus Vaziri
Mutagenesis is a hallmark and enabling characteristic of cancer cells. The E3 ubiquitin ligase RAD18 and its downstream effectors, the 'Y-family' Trans-Lesion Synthesis (TLS) DNA polymerases, confer DNA damage tolerance at the expense of DNA replication fidelity. Thus, RAD18 and TLS polymerases are attractive candidate mediators of mutagenesis and carcinogenesis. The skin cancer-propensity disorder xeroderma pigmentosum-variant (XPV) is caused by defects in the Y-family DNA polymerase Pol eta (Polη). However it is unknown whether TLS dysfunction contributes more generally to other human cancers...
May 8, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29675426/a-novel-method-for-drug-screen-to-regulate-g-protein-coupled-receptors-in-the-metabolic-network-of-alzheimer-s-disease
#13
Yang Li, Wei Zheng, Wuyun Qiqige, Shujuan Cao, Jishou Ruan, Yanping Zhang
Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder and the pathogenesis of AD is poorly understood. G protein-coupled receptors (GPCRs) are involved in numerous key AD pathways and play a key role in the pathology of AD. To fully understand the pathogenesis of AD and design novel drug therapeutics, analyzing the connection between AD and GPCRs is of great importance. In this paper, we firstly build and analyze the AD-related pathway by consulting the KEGG pathway of AD and a mass of literature and collect 25 AD-related GPCRs for drug discovery...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29627665/viability-and-membrane-lipid-composition-under-a-57mt-static-magnetic-field-in-salmonella-hadar
#14
Ramla Ben Mouhoub, Alya El May, Imen Boujezza, Mohamed Marouen Sethom, Moncef Feki, Ahmed Landoulsi
The aim of this work is to demonstrate the effects of a static magnetic field (SMF) with an induction 12 equal to 57mT on the viability and membrane lipid composition of Salmonella Hadar. Results showed an increase in the viability of exposed bacteria compared to controls after 9h of exposure. Analysis with gas chromatography of total lipids (TLs) and different fractions of phospholipids: phosphatidylglycerols (PGs), phosphatidylethanolamines (PEs), and cardiolipins (CLs), separated by thin layer chromatography revealed changes in fatty acid levels during exposure...
March 29, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29625036/coordinated-activity-of-y-family-tls-polymerases-and-exo1-protects-non-s-phase-cells-from-uv-induced-cytotoxic-lesions
#15
Sarah Sertic, Antonio Mollica, Ilaria Campus, Stefania Roma, Emanuela Tumini, Andrés Aguilera, Marco Muzi-Falconi
No abstract text is available yet for this article.
April 5, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29608741/critically-elevated-potassium-in-a-55-year-old-female-with-chronic-lymphocytic-leukemia
#16
Jing Cao, Amy B Karger
Hyperkalemia in specimens from patients with chronic lymphocytic leukemia (CLL) may be due to tumor lysis syndrome (TLS) or specimen processing. This report describes a 55-year-old Caucasian woman with CLL who presented to an outside hospital with hyperkalemia and was transferred to a second hospital. Initial evaluation on the core laboratory chemistry analyzer (the VITROS 5600) and the ABL90 FLEX blood gas analyzer showed markedly elevated levels of potassium (K+). TLS was subsequently diagnosed, and dialysis was initiated...
March 28, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29590477/rna-splicing-factor-sart3-regulates-translesion-dna-synthesis
#17
Min Huang, Bo Zhou, Juanjuan Gong, Lingyu Xing, Xiaolu Ma, Fengli Wang, Wei Wu, Hongyan Shen, Chenyi Sun, Xuefei Zhu, Yeran Yang, Yazhou Sun, Yang Liu, Tie-Shan Tang, Caixia Guo
Translesion DNA synthesis (TLS) is one mode of DNA damage tolerance that uses specialized DNA polymerases to replicate damaged DNA. DNA polymerase η (Polη) is well known to facilitate TLS across ultraviolet (UV) irradiation and mutations in POLH are implicated in skin carcinogenesis. However, the basis for recruitment of Polη to stalled replication forks is not completely understood. In this study, we used an affinity purification approach to isolate a Polη-containing complex and have identified SART3, a pre-mRNA splicing factor, as a critical regulator to modulate the recruitment of Polη and its partner RAD18 after UV exposure...
March 24, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29568306/can-leaf-water-content-be-estimated-using-multispectral-terrestrial-laser-scanning-a-case-study-with-norway-spruce-seedlings
#18
Samuli Junttila, Junko Sugano, Mikko Vastaranta, Riikka Linnakoski, Harri Kaartinen, Antero Kukko, Markus Holopainen, Hannu Hyyppä, Juha Hyyppä
Changing climate is increasing the amount and intensity of forest stress agents, such as drought, pest insects, and pathogens. Leaf water content, measured here in terms of equivalent water thickness (EWT), is an early indicator of tree stress that provides timely information about the health status of forests. Multispectral terrestrial laser scanning (MS-TLS) measures target geometry and reflectance simultaneously, providing spatially explicit reflectance information at several wavelengths. EWT and leaf internal structure affect leaf reflectance in the shortwave infrared region that can be used to predict EWT with MS-TLS...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29551515/coordinated-activity-of-y-family-tls-polymerases-and-exo1-protects-non-s-phase-cells-from-uv-induced-cytotoxic-lesions
#19
Sarah Sertic, Antonio Mollica, Ilaria Campus, Stefania Roma, Emanuela Tumini, Andrés Aguilera, Marco Muzi-Falconi
UV-induced photoproducts are responsible for the pathological effects of sunlight. Mutations in nucleotide excision repair (NER) cause severe pathologies characterized by sunlight sensitivity, coupled to elevated predisposition to cancer and/or neurological dysfunctions. We have previously shown that in UV-irradiated non-cycling cells, only a particular subset of lesions activates the DNA damage response (DDR), and this requires NER and EXO1 activities. To define the molecular mechanism acting at these lesions, we demonstrate that Y family TLS polymerases are recruited at NER- and EXO1-positive lesion sites in non-S phase cells...
March 3, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29545434/management-of-tumour-lysis-syndrome-during-first-line-palliative-chemotherapy-for-high-volume-colorectal-cancer
#20
Helena S Gouveia, Sílvia O Lopes, Ana Luísa Faria
Tumour lysis syndrome (TLS) is a rare oncological emergency in solid tumours. Because it is associated with bad short-term prognosis, early recognition and treatment are mandatory. This case refers to a middle-aged woman who presented with stage IV colon cancer, with massive hepatic involvement. After three cycles of first-line FOLFOX (folinic acid, 5-fluorouracil and oxaliplatin), she developed acute kidney injury and hyperkalaemia that did not respond to standard measures. High suspicion of TLS prompted further corroborating investigations and early intensive care unit admission...
March 15, 2018: BMJ Case Reports
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