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https://www.readbyqxmd.com/read/29152550/tertiary-lymphoid-structures-associate-with-tumour-stage-in-urothelial-bladder-cancer
#1
Madhuri Koti, Amanda Shou Xu, Kevin Yi Mi Ren, Kash Visram, Runhan Ren, David M Berman, D Robert Siemens
Background: Urothelial bladder cancer (UBC) is a highly prevalent disease in North America, however its optimal management remains elusive. The contribution of B cell associated responses is poorly understood in bladder cancer. Lymphoid neogenesis is a hallmark of an active immune response at tumor sites that sometimes leads to formation of tertiary lymphoid structures (TLS) that resemble germinal centers formed in secondary lymphoid organs. Objective: This study was conducted with an aim to investigate the presence and characteristics of TLS in UBC with a focus to compare and contrast the TLS formation in treatment naive low grade non-muscle invasive (NMIBC) and muscle invasive bladder cancers (MIBC)...
October 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/29149962/impact-of-acute-infection-requiring-hospitalization-on-tacrolimus-blood-levels-in-kidney-transplant-recipients
#2
C Percy, Z Hassoun, M Mourad, M De Meyer, C Beguin, M Jadoul, E Goffin, P Wallemacq, N Kanaan
BACKGROUND: Tacrolimus is metabolized by members of the cytochrome p450 3A subfamily, and its bioavailability depends also on P-glycoprotein. We have observed that some patients admitted for infection presented with increased tacrolimus trough levels (TLs). The aim of the study was to assess the impact of infection on tacrolimus TLs and to determine the factors involved in TL fluctuations. METHODS: This retrospective cohort study included patients transplanted with a kidney between 2009 and 2011 who were hospitalized for an acute infection...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29141335/-previous-hiv-testing-behavior-and-related-factors-in-men-who-have-sex-with-men-in-gay-bathroom-in-hangzhou-zhejiang-province
#3
X Zhou, X H Pan, M Y Luo, L Chen, L He, H Wang, T T Jiang, Q Q Ma
Objective: To understand the related factors on previous HIV testing behavior among MSM who visit gay bathroom in Hangzhou, Zhejiang province. Methods: Through time-location sampling (TLS) survey, men who had oral sex or anal sex with men in past 6 months were interviewed in the gay bathroom in Hangzhou from October 2015 to January 2016. Software SPSS 22.0 was used to analyze the HIV testing acceptance, sexual behaviors and condom usage of MSM during past 6 months, and χ(2) test and logistic regression model were used for univariate and multivariate analyses...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29130003/spontaneous-tumor-lysis-syndrome-due-to-uterine-leiomyosarcoma-with-lung-metastases
#4
Vivek Alaigh, Debapriya Datta
Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. TLS is usually seen after the initiation of chemotherapy for hematologic malignancies. TLS occurring spontaneously, without initiation of chemotherapy, is rare and its occurrence in solid tumors is rarer still...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29116081/a-method-for-measuring-the-distribution-of-the-shortest-telomeres-in-cells-and-tissues
#5
Tsung-Po Lai, Ning Zhang, Jungsik Noh, Ilgen Mender, Enzo Tedone, Ejun Huang, Woodring E Wright, Gaudenz Danuser, Jerry W Shay
Improved methods to measure the shortest (not just average) telomere lengths (TLs) are needed. We developed Telomere Shortest Length Assay (TeSLA), a technique that detects telomeres from all chromosome ends from <1 kb to 18 kb using small amounts of input DNA. TeSLA improves the specificity and efficiency of TL measurements that is facilitated by user friendly image-processing software to automatically detect and annotate band sizes, calculate average TL, as well as the percent of the shortest telomeres...
November 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29105243/performance-of-multiplex-fusion-gene-testing-in-pediatric-acute-myeloid-leukemia
#6
Yuka Iijima-Yamashita, Hidemasa Matsuo, Miho Yamada, Takao Deguchi, Nobutaka Kiyokawa, Akira Shimada, Akio Tawa, Hiroyuki Takahashi, Daisuke Tomizawa, Takashi Taga, Akitoshi Kinoshita, Souichi Adachi, Keizo Horibe
BACKGROUND: Gene abnormalities, particularly chromosome rearrangements generating gene fusions, are associated with clinical characteristics and prognosis in pediatric acute myeloid leukemia (AML). Karyotyping is generally performed to enable risk stratification; however, the results are not always consistent with those generated by reverse transcription-polymerase chain reaction (RT-PCR), and more accurate and rapid methods are required. METHODS: A total of 487 samples from de novo AML patients enrolled in the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05 study (n = 448), and acute promyelocytic leukemia (APL) patients enrolled in the JPLSG AML-P05 study (n = 39) were available for this investigation...
November 4, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29104583/not-all-trees-sleep-the-same-high-temporal-resolution-terrestrial-laser-scanning-shows-differences-in-nocturnal-plant-movement
#7
András Zlinszky, Bence Molnár, Anders S Barfod
Circadian leaf movements are widely known in plants, but nocturnal movement of tree branches were only recently discovered by using terrestrial laser scanning (TLS), a high resolution three-dimensional surveying technique. TLS uses a pulsed laser emitted in a regular scan pattern for rapid measurement of distances to the targets, thus producing three dimensional point cloud models of sub-centimeter resolution and accuracy in a few minutes. Here, we aim to gain an overview of the variability of circadian movement of small trees across different taxonomic groups, growth forms and leaf anatomies...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29099687/conjugated-bilirubin-upregulates-tim-3-expression-on-cd4-cd25-t-cells-anti-inflammatory-implications-for-hepatitis-a-virus-infection
#8
Jorge L Trujillo-Ochoa, Karla F Corral-Jara, Claudia L Charles-Niño, Arturo Panduro, Nora A Fierro
Bilirubin (BR), a metabolite with increased concentrations in plasma during viral hepatitis, has been recognized as a potential immune-modulator. We recently reported that conjugated BR (CB) augments regulatory T cell (Treg) suppressor activity during acute hepatitis A virus (HAV) infection. However, the mechanisms related to the effects of CB on Treg function in the course of hepatotropic viral diseases have not been elucidated. T cell immunoglobulin domain and mucin domain 3 (TIM-3), via its interactions with galectin-9 (GAL-9), is a receptor associated with enhanced Treg function...
November 3, 2017: Viral Immunology
https://www.readbyqxmd.com/read/29073105/paf-promotes-stemness-and-radioresistance-of-glioma-stem-cells
#9
Derrick Sek Tong Ong, Baoli Hu, Yan Wing Ho, Charles-Etienne Gabriel Sauvé, Christopher A Bristow, Qianghu Wang, Asha S Multani, Peiwen Chen, Luigi Nezi, Shan Jiang, Claire Elizabeth Gorman, Marta Moreno Monasterio, Dimpy Koul, Matteo Marchesini, Simona Colla, Eun-Jung Jin, Erik P Sulman, Denise J Spring, Wai-Kwan Alfred Yung, Roel G W Verhaak, Lynda Chin, Y Alan Wang, Ronald A DePinho
An integrated genomic and functional analysis to elucidate DNA damage signaling factors promoting self-renewal of glioma stem cells (GSCs) identified proliferating cell nuclear antigen (PCNA)-associated factor (PAF) up-regulation in glioblastoma. PAF is preferentially overexpressed in GSCs. Its depletion impairs maintenance of self-renewal without promoting differentiation and reduces tumor-initiating cell frequency. Combined transcriptomic and metabolomic analyses revealed that PAF supports GSC maintenance, in part, by influencing DNA replication and pyrimidine metabolism pathways...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29071010/error-prone-and-error-free-translesion-dna-synthesis-over-site-specifically-created-dna-adducts-of-aryl-hydrocarbons-3-nitrobenzanthrone-and-4-aminobiphenyl
#10
REVIEW
Takashi Yagi, Yoshihiro Fujikawa, Tomoko Sawai, Takeji Takamura-Enya, Sayoko Ito-Harashima, Masanobu Kawanishi
Aryl hydrocarbons such as 3-nitrobenzanthrone (NBA), 4-aminobiphenyl (ABP), acetylaminofluorene (AAF), benzo(a)pyrene (BaP), and 1-nitropyrene (NP) form bulky DNA adducts when absorbed by mammalian cells. These chemicals are metabolically activated to reactive forms in mammalian cells and preferentially get attached covalently to the N(2) or C8 positions of guanine or the N(6) position of adenine. The proportion of N(2) and C8 guanine adducts in DNA differs among chemicals. Although these adducts block DNA replication, cells have a mechanism allowing to continue replication by bypassing these adducts: translesion DNA synthesis (TLS)...
October 2017: Toxicological Research
https://www.readbyqxmd.com/read/29063247/methodological-considerations-of-terrestrial-laser-scanning-for-vegetation-monitoring-in-the-sagebrush-steppe
#11
Kyle E Anderson, Nancy F Glenn, Lucas P Spaete, Douglas J Shinneman, David S Pilliod, Robert S Arkle, Susan K McIlroy, DeWayne R Derryberry
Terrestrial laser scanning (TLS) provides fast collection of high-definition structural information, making it a valuable field instrument to many monitoring applications. A weakness of TLS collections, especially in vegetation, is the occurrence of unsampled regions in point clouds where the sensor's line-of-sight is blocked by intervening material. This problem, referred to as occlusion, may be mitigated by scanning target areas from several positions, increasing the chance that any given area will fall within the scanner's line-of-sight from at least one position...
October 23, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29058106/line-of-fire-what-happened-at-the-wantabadgery-seige
#12
Roger W Byard, Adam Ford, Tony Raymond, Jeremy J Sofonia, Owen Kaluza, David G Barnes
A gunfight between police and a gang of men led by the self-styled "Captain Moonlite", a.k.a. George Scott, occurred on 16th November 1879 at a farmhouse near Wantabadgery Station in the colony of New South Wales. The skirmish resulted in the deaths of two bushrangers and one police officer. As a result, Captain Moonlite and Thomas Rogan were hung in Sydney's Darlinghurst Gaol on 20 January 1880 for the murder of Constable Edward Webb-Bowen. Culpability for firing the fatal shot, however, has remained a source of controversy...
October 23, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29055779/ubiquitome-analysis-reveals-pcna-associated-factor-15-paf15-as-a-specific-ubiquitination-target-of-uhrf1-in-embryonic-stem-cells
#13
Elisabeth Karg, Martha Smets, Joel Ryan, Ignasi Forné, Weihua Qin, Christopher B Mulholland, Georgia Kalideris, Axel Imhof, Sebastian Bultmann, Heinrich Leonhardt
Ubiquitination is a multifunctional posttranslational modification controlling the activity, subcellular localization and stability of proteins. The E3 ubiquitin ligase UHRF1 is an essential epigenetic factor that recognizes repressive histone marks as well as hemi-methylated DNA and recruits DNMT1. To explore enzymatic functions of UHRF1 beyond epigenetic regulation we conducted a comprehensive screen in mouse embryonic stem cells to identify novel ubiquitination targets of UHRF1 and its paralogue UHRF2. We found differentially ubiquitinated peptides associated with a variety of biological processes such as transcriptional regulation and DNA damage response...
October 18, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29041916/early-coordinated-rehabilitation-in-acute-phase-after-hip-fracture-a-model-for-increased-patient-participation
#14
Gillian Asplin, Gunnel Carlsson, Lena Zidén, Gunilla Kjellby-Wendt
BACKGROUND: Studies have shown that patients with hip fracture treated in a Comprehensive Geriatric Care (CGC) unit report better results in comparison to orthopaedic care. Furthermore, involving patients in their healthcare by encouraging patient participation can result in better quality of care and improved outcomes. To our knowledge no study has been performed comparing rehabilitation programmes within a CGC unit during the acute phase after hip fracture with focus on improving patients' perceived participation and subsequent effect on patients' function...
October 17, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29039755/comparing-riegl-ricopter-uav-lidar-derived-canopy-height-and-dbh-with-terrestrial-lidar
#15
Benjamin Brede, Alvaro Lau, Harm M Bartholomeus, Lammert Kooistra
In recent years, LIght Detection And Ranging (LiDAR) and especially Terrestrial Laser Scanning (TLS) systems have shown the potential to revolutionise forest structural characterisation by providing unprecedented 3D data. However, manned Airborne Laser Scanning (ALS) requires costly campaigns and produces relatively low point density, while TLS is labour intense and time demanding. Unmanned Aerial Vehicle (UAV)-borne laser scanning can be the way in between. In this study, we present first results and experiences with the RIEGL RiCOPTER with VUX ® -1UAV ALS system and compare it with the well tested RIEGL VZ-400 TLS system...
October 17, 2017: Sensors
https://www.readbyqxmd.com/read/29016475/relationship-between-physiological-off-ice-testing-on-ice-skating-and-game-performance-in-division-i-women-s-ice-hockey-players
#16
Michelle Boland, Emily M Miele, Katie Delude
The purpose was to identify off-ice testing variables that correlate to skating and game performance in Division I collegiate women ice hockey players. Twenty female, forward and defensive players (19.95 ± 1.35 yr) were assessed for weight, height, percent fat mass (%FAT), bone mineral density, predicted one repetition maximum (RM) absolute and relative (REL%) bench press (BP) and hex bar deadlift (HDL), lower body explosive power, anaerobic power, countermovement vertical jump (CMJ), maximum inspiratory pressure (MIP), and on-ice repeated skate sprint (RSS) performance...
October 7, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28984373/pulmonary-ultrasound-scoring-system-for-intubated-critically-ill-patients-and-its-association-with-clinical-metrics-and-mortality-a-prospective-cohort-study
#17
David M Tierney, Lori L Boland, Josh D Overgaard, Joshua S Huelster, Ann Jorgenson, James P Normington, Roman R Melamed
PURPOSE: Pulmonary ultrasound (PU) examination at the point-of-care can rapidly identify the etiology of acute respiratory failure (ARF) and assess treatment response. The often-subjective classification of PU abnormalities makes it difficult to document change over time and communicate findings across providers. The study goal was to develop a simple, PU scoring system that would allow for standardized documentation, have high interprovider agreement, and correlate with clinical metrics...
October 6, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28982910/febuxostat-as-a-prophylaxis-for-tumor-lysis-syndrome-in-children-with-hematological-malignancies
#18
Kenji Kishimoto, Ryoji Kobayashi, Daiki Hori, Hirozumi Sano, Daisuke Suzuki, Kunihiko Kobayashi
AIM: The aim of the present study was to determine if febuxostat could prevent tumor lysis syndrome (TLS) in children who received induction chemotherapy for hematologic malignancies. PATIENTS AND METHODS: A retrospective analysis was performed in 45 pediatric patients with hematological malignancies who received febuxostat (10 mg daily, n=20) or allopurinol (300 mg/m(2) daily, n=25) as a prophylaxis for TLS. RESULTS: A significant decrease of serum uric acid (UA) level was observed in patients with febuxostat over the first 2 days (6...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28978678/pufa-status-and-methylmercury-exposure-are-not-associated-with-leukocyte-telomere-length-in-mothers-or-their-children-in-the-seychelles-child-development-study
#19
Alison J Yeates, Sally W Thurston, Huiqi Li, Maria S Mulhern, Emeir M McSorley, Gene E Watson, Conrad F Shamlaye, J J Strain, Gary J Myers, Philip W Davidson, Edwin van Wijngaarden, Karin Broberg
Background: Leukocyte telomere length (TL) is associated with age-related diseases and early mortality, but there is a lack of data on the determinants of TL in early life. Evidence suggests that dietary intake of marine n-3 (ω-3) polyunsaturated fatty acids (PUFAs) is protective of telomere attrition, yet the effect of methylmercury exposure, also found in fish, on TL is unknown.Objective: The aim of this study was to investigate the associations between prenatal PUFA status, methylmercury exposure, and TL in mothers and children in the SCDS (Seychelles Child Development Study), for whom fish consumption is high...
November 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28977508/nucleic-acid-binding-proteins-affect-the-subcellular-distribution-of-phosphorothioate-antisense-oligonucleotides
#20
Jeffrey K Bailey, Wen Shen, Xue-Hai Liang, Stanley T Crooke
Antisense oligonucleotides (ASOs) are versatile tools that can regulate multiple steps of RNA biogenesis in cells and living organisms. Significant improvements in delivery, potency, and stability have been achieved through modifications within the oligonucleotide backbone, sugar and heterocycles. However, these modifications can profoundly affect interactions between ASOs and intracellular proteins in ways that are only beginning to be understood. Here, we report that ASOs with specific backbone and sugar modifications can become localized to cytoplasmic ribonucleoprotein granules such as stress granules and those seeded by the aggregation of specific ASO-binding proteins such as FUS/TLS (FUS) and PSF/SFPQ (PSF)...
October 13, 2017: Nucleic Acids Research
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