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Tasha R Stanton
Clinical prediction rules (CPRs) are created to help guide clinical decision making. To do this, they use the presence or absence of certain factors that have been shown to meaningfully predict a patient's prognosis, diagnosis, or response to treatment. While representing a seminal methodological step forward in individualized care, one of the main drawbacks of CPRs continues to be validation studies that do not support the initially derived CPR. This is particularly important because validation of CPRs in an independent patient population prior to clinical implementation is essential...
July 2016: Journal of Orthopaedic and Sports Physical Therapy
Kansuda Leelahapongsathon, Ynte Hein Schukken, Tanu Pinyopummintr, Witaya Suriyasathaporn
The objectives of study were to determine the transmission parameters (β), durations of infection, and basic reproductive numbers (R0) of both Streptococcus agalactiae and Streptococcus uberis as pathogens causing mastitis outbreaks in dairy herds. A 10-mo longitudinal study was performed using 2 smallholder dairy herds with mastitis outbreaks caused by Strep. agalactiae and Strep. uberis, respectively. Both herds had poor mastitis control management and did not change their milking management during the entire study period...
February 2016: Journal of Dairy Science
Joe Luis Pantoja, Zhihong Zhang, Mehrzad Tartibi, Kay Sun, Warrick Macmillan, Julius M Guccione, Liang Ge, Mark B Ratcliffe
BACKGROUND: Surgical ventricular restoration (Dor procedure) is generally thought to reduce left ventricular (LV) myofiber stress (FS) but to adversely affect pump function. However, the underlying mechanism is unclear. The goal of this study was to determine the effect of residual stress (RS) on LV FS and pump function after the Dor procedure. METHODS: Previously described finite element models of the LV based on magnetic resonance imaging data obtained in 5 sheep 16 weeks after anteroapical myocardial infarction were used...
December 2015: Annals of Thoracic Surgery
Mustafa Cengiz, Seren Ozenirler
OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease and assessment of liver fibrosis is important. We aimed to investigate the performance of red cell volume distribution width-to-platelet ratio (RPR) in predicting liver fibrosis in patients with NAFLD and to compare it with well-known noninvasive predicting fibrosis scores (alanine aminotransferase ratio, aspartate aminotransferase platelet ratio index, fibrosis index, fibrosis 4, and fibrosis, cirrhosis index)...
November 2015: European Journal of Gastroenterology & Hepatology
Keran Moll, Shawn X Sun, Jeffrey J Ellis, Andrew Howe, Alpesh Amin
BACKGROUND: Chronic obstructive pulmonary disease (COPD) exacerbations are associated with declining lung function and health-related quality of life, and increased hospitalization and mortality. Clinical trials often poorly represent the elderly and thus have only partial applicability to their clinical care. OBJECTIVE: To compare exacerbations, COPD-related health care utilization (HCU), and costs in a predominantly elderly Medicare COPD population initiated on roflumilast versus those not initiated on roflumilast...
2015: International Journal of Chronic Obstructive Pulmonary Disease
Aileen R Neilson, Hanne Bruhn, Christine M Bond, Alison M Elliott, Blair H Smith, Philip C Hannaford, Richard Holland, Amanda J Lee, Margaret Watson, David Wright, Paul McNamee
OBJECTIVES: To explore differences in mean costs (from a UK National Health Service perspective) and effects of pharmacist-led management of chronic pain in primary care evaluated in a pilot randomised controlled trial (RCT), and to estimate optimal sample size for a definitive RCT. DESIGN: Regression analysis of costs and effects, using intention-to-treat and expected value of sample information analysis (EVSI). SETTING: Six general practices: Grampian (3); East Anglia (3)...
2015: BMJ Open
Feng Qin, Yanjuan Wang, Lijuan Wang, Longshan Zhao, Li Pan, Maosheng Cheng, Famei Li
A sensitive and enantioselective vancomycin chiral stationary phase high-performance liquid chromatography-tandem mass spectrometry method was developed for the determination of trantinterol enantiomers in human plasma. Baseline resolution was achieved using the vancomycin chiral stationary phase known as Chirobiotic V with polar ionic mobile phase consisting of acetonitrile-methanol (60:40, v/v) containing 0.01% ammonia and 0.02% acetic acid at a flow rate of 1.0 mL/min. Waters Oasis HLB C18 solid phase extraction cartridges were used in the sample preparation of trantinterol samples from plasma...
May 2015: Chirality
Pietro Felice, Carlo Barausse, Rodolfo Blasone, Gianpaolo Favaretto, Claudio Stacchi, Matteo Calvo, Carlo Marin, Jacopo Buti, Marco Esposito
PURPOSE: To compare the clinical effectiveness of two implant systems: Way Milano and Kentron (Geass, Pozzuolo del Friuli, UD, Italy). MATERIALS AND METHODS: A total of 64 patients requiring at least two single crowns or partial fixed dental prostheses supported by a maximum of three implants had their sites randomised according to a split-mouth design to receive both implant systems at six centres. Patients were followed up for 1 year after initial loading. Outcome measures were: prosthesis/implant failures; any complication; peri-implant marginal bone level changes; and clinician preference...
2014: European Journal of Oral Implantology
Anthony P Sclafani
The objective of this study was to determine the effect of platelet-rich fibrin matrix (PRFM) treatment on androgenetic alopecia. Prospective cohort study of 15 (9 male and 6 female) subjects with androgenetic alopecia for at least 1 year who were treated with intradermal injections of autologous PRFM three times on a monthly basis. Hair density indices were measured in triplicate in the same area of the scalp before the treatment and 1, 2, 3 and 6 months after initial treatment. Hair density index (HDI) measurements were obtained and compared with pretreatment values for each subject...
April 2014: Facial Plastic Surgery: FPS
Xavier Mariette, Raphaèle Seror, Luca Quartuccio, Gabriel Baron, Sara Salvin, Martina Fabris, Frederic Desmoulins, Gaétane Nocturne, Philippe Ravaud, Salvatore De Vita
BACKGROUND: Increased expression of B cell activating factor (BAFF or B lymphocyte stimulator) may explain the B cell activation characteristic of primary Sjögren's syndrome (pSS). OBJECTIVES: To evaluate the efficacy and safety of belimumab, targeting BAFF, in patients with pSS. METHODS: Patients were included in this bi-centric prospective 1-year open-label trial if they fulfilled American European Consensus group criteria, were anti-Sjögren's syndrome A-positive and had current systemic complications or salivary gland enlargement, or early disease (<5 years), or biomarkers of B cell activation...
March 2015: Annals of the Rheumatic Diseases
Lina M Aguirre, César Cardona, John W Miles, Guillermo Sotelo
Nymphs and adults of several spittlebug (Hemiptera: Cercopidae) species are key pests of forage brachiariagrasses (Brachiaria spp.) in tropical America. To support current breeding programs, a series of experiments aimed at characterizing the mechanisms of resistance to adult feeding damage were carried out. Five genotypes were used: two susceptible checks (CIAT 0606 and CIAT 0654) and three nymph-resistant genotypes (CIAT 36087, CIAT 6294, and SX01NO/0102). Test insects were Aeneolamia varia (F.), A. reducta (Lallemand), and Zulia carbonaria (Lallemand)...
August 2013: Journal of Economic Entomology
Han Ting Chou, Jeng-Yi Li, Chung-Dar Lu
Growth of Pseudomonas aeruginosa on diamines cadaverine, putrescine, and diaminopropane requires the γ-glutamylation pathway to convert these diamines into δ-aminovalerate (AMV), γ-aminobutyrate (GABA), and β-alanine. From DNA microarrays experiments the agtABCD operon (PA0603-0606) encoding components for an ABC transporter system was found inducible by exogenous AMV, GABA, and β-alanine, but not by diamines. Induction of the agtABCD operon was abolished in the mutants of upstream agtS (PA0600) or agtR (PA0601) genes encoding the membrane-anchored sensor and the response regulator of a two-component regulatory system, respectively...
January 2014: Current Microbiology
Yutaka Usui, Akiko Kaga, Fumikazu Sakai, Ayako Shiono, Ken-Ichiro Komiyama, Koichi Hagiwara, Minoru Kanazawa
OBJECTIVES: To assess clinical, laboratory and radiographic findings associated with outcomes and to clarify more practical ways to predict hospital mortality in patients with acute exacerbation (AE) of chronic fibrosing interstitial pneumonia (CFIP). DESIGN: Single-centre retrospective cohort study. SETTING: University Hospital in Japan. PARTICIPANTS: We identified 51 consecutive patients with AE of idiopathic CFIP through multidisciplinary discussion...
2013: BMJ Open
Rosanna Marsella, Domenico Santoro, Kim Ahrens, Amanda L Thomas
BACKGROUND: Atopic dermatitis (AD) results from complex interactions between an impaired skin barrier and immunological stimulation. Filaggrin is a key protein for the skin barrier, and its expression is decreased in subsets of atopic dogs and can be modified by inflammation; thus, immunomodulatory approaches may alter its expression. Probiotics have been explored for the prevention and treatment of allergies, owing to their immunomodulatory properties; however, it is currently unknown whether they can modulate filaggrin expression...
April 2013: Veterinary Dermatology
Lauren Kropp, Christopher J Balamucki, Christopher G Morris, Jessica Kirwan, Armand B Cognetta, Charles B Stoer, William M Mendenhall
PURPOSE: To update our experience treating cutaneous squamous cell carcinoma (SCC) and basal cell carcinomas (BCC) of the head and neck with incidental perineural invasion (PNI) using Mohs resection followed by radiotherapy (RT). We compare outcomes between head and neck patients with incidental PNI who received Mohs surgery and those who did not. MATERIALS AND METHODS: From 1987 to 2009, 36 patients were treated with Mohs resection followed by postoperative RT; 82 patients were treated with resection other than Mohs followed by postoperative RT...
September 2013: American Journal of Otolaryngology
Fares G Mouchantaf, Eugene Shostak, Carla R Lamb
BACKGROUND: A case-control study was conducted to identify the possible risk factors for acute respiratory failure in patients undergoing bronchoscopy. We also aimed to estimate the financial costs incurred in the care of high-risk patients. METHODS: All hypoxic respiratory complications that occurred during bronchoscopy between January 2005 and March 2009 were reviewed. Mild hypoxia was defined as the need for up to 6 L of nasal cannula, moderate hypoxia as requiring up to 100% nonrebreather face mask, and severe hypoxia requiring intubation and mechanical ventilation to maintain pulse oximetry above 90%...
July 2012: Journal of Bronchology & Interventional Pulmonology
Nathan L Mata, Jay B Lichter, Roger Vogel, Yun Han, Tam V Bui, Lawrence J Singerman
BACKGROUND: Excessive accumulation of retinol-based toxins has been implicated in the pathogenesis of geographic atrophy (GA). Fenretinide, an orally available drug that reduces retinol delivery to the eye through antagonism of serum retinol-binding protein (RBP), was used in a 2-year trial to determine whether retinol reduction would be effective in the management of geographic atrophy. METHODS: The efficacy of fenretinide (100 and 300 mg daily, orally) to slow lesion growth in geographic atrophy patients was examined in a 2-year, placebo-controlled double-masked trial that enrolled 246 patients at 30 clinical sites in the United States...
March 2013: Retina
Marie-Adele S Kress, Brian T Collins, Sean P Collins, Anatoly Dritschilo, Gregory Gagnon, Keith Unger
BACKGROUND: Stereotactic body radiation therapy (SBRT) is an emerging treatment option for liver tumors. This study evaluated outcomes after SBRT to identify prognostic variables and to develop a novel scoring system predictive of survival. METHODS: The medical records of 52 patients with a total of 85 liver lesions treated with SBRT from 2003 to 2010 were retrospectively reviewed. Twenty-four patients had 1 lesion; 27 had 2 or more. Thirteen lesions were primary tumors; 72 were metastases...
2012: Radiation Oncology
Guohui Yu, Ping Cheng, Yanhong Chen, Yongjian Li, Zihong Yang, Yuanfeng Chen, Jeffery K Tomberlin
The growth and development of black soldier fly, Hermetia illucens (L.), larvae fed chicken manure inoculated with bacteria isolated from black soldier fly larvae and associated larval feed was evaluated. Four strains of Bacillus subtilis were evaluated. B. subtilis strains S15, S16, S19, were isolated from the gut of black soldier fly larvae. B. natto strain D1 was isolated from the diet fed to black soldier fly larvae. These bacteria were added individually into nonsterile 200 g fresh hen manure at 10(6) cfu/g and homogenized...
February 2011: Environmental Entomology
A Lopes Gallinaro, C A Silva, C N Rabelo, M T Correia Caleiro, J F de Carvalho
PURPOSE: To evaluate sexual function of antiphospholipid syndrome (APS) patients using the Brazilian version of the validated International Index of Erectile Function (IIEF). MATERIALS AND METHODS: Eleven APS male patients (Sapporo criteria) were age and race-matched with 22 healthy controls. Demographic and clinical data, drug use and antiphospholipid antibodies were evaluated. The IIEF was also self-applied. RESULTS: Mean age (p = 0.114), frequency of Caucasian race (p = 1...
March 2012: Lupus
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