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https://www.readbyqxmd.com/read/29342901/omega-3-polyunsaturated-fatty-acids-time-dependently-reduce-cell-viability-and-oncogenic-microrna-21-expression-in-estrogen-receptor-positive-breast-cancer-cells-mcf-7
#1
Lauren LeMay-Nedjelski, Julie K Mason-Ennis, Amel Taibi, Elena M Comelli, Lilian U Thompson
The omega-3 polyunsaturated fatty acid (n-3 PUFA), α-linolenic acid (ALA), and its metabolites, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), independently reduce the growth of breast cancer cells in vitro, but the mechanisms, which may involve microRNA (miRNA), are still unclear. The expression of the oncomiR, miR-21, is reduced by DHA treatment, but the effects of ALA on miR-21, alone or combined with EPA and DHA under physiologically relevant concentrations, have not been investigated. The effects of ALA alone and +/-EPA and DHA at the blood molar ratios seen in either humans (1...
January 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29334949/flaxseed-enriched-diets-change-milk-concentration-of-the-antimicrobial-danofloxacin-in-sheep
#2
Jon Andoni Otero, Dafne García-Mateos, Indira Alvarez-Fernández, Rocío García-Villalba, Juan Carlos Espín, Ana Isabel Álvarez, Gracia Merino
BACKGROUND: Flaxseed is the most common and rich dietary source of lignans and is an acceptable supply of energy for livestock. Flaxseed lignans are precursors of enterolignans, mainly enterolactone and enterodiol, produced by the rumen and intestinal microbiota of mammals and have many important biological properties as phytoestrogens. Potential food-drug interactions involving flaxseed may be relevant for veterinary therapy, and for the quality and safety of milk and dairy products...
January 15, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29323210/anticancer-potentiality-of-lignan-rich-fraction-of-six-flaxseed-cultivars
#3
Shahira M Ezzat, Samia A Shouman, Abeer Elkhoely, Yasmin M Attia, Mohamed S Elsesy, Amira S El Senousy, Mouchira A Choucry, Sabah H El Gayed, Abeer A El Sayed, Essam Abdel Sattar, Nebal El Tanbouly
The objective of our study is to highlight the therapeutic effect and mechanism of action by which purified Flaxseed hydrolysate (PFH) which is a lignan rich fraction exerts its anticancer activity on a human breast cancer cell line (T47D) and in mice bearing tumor. HPLC analysis of PFH of six flaxseed cultivars had shown that PFH of the cultivar Giza 9 (PFH-G9) contains the highest concentration of SDG (81.64 mg/g). The in vitro cytotoxic potentiality of PFH's of six flaxseed cultivars was screened against a panel of human cancer cell lines...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29303360/flaxseed-lignans-enhance-the-cytotoxicity-of-chemotherapeutic-agents-against-breast-cancer-cell-lines-mda-mb-231-and-skbr3
#4
Yunyun Di, Franklyn De Silva, Edward S Krol, Jane Alcorn
Systemic cytotoxic chemotherapy remains the mainstay of metastatic breast cancer; however, prognosis and overall survival is unfavorable due to inadequate treatment response and/or unacceptable toxicity. Natural compounds and their active metabolites receive increasing attention as possible adjuvant therapy with cancer chemotherapeutics to improve treatment response, survival rates, and quality of life of breast cancer patients. This study investigated the combination of flaxseed lignans (Secoisolariciresinol and Enterolactone) with classic chemotherapeutic agents (Docetaxel, Doxorubicin, and Carboplatin) with different mechanisms of action to determine whether flaxseed lignans could enhance the cytotoxic effect of such drugs in the metastatic breast cancer cell lines, SKBR3 and MDA-MB-231...
January 5, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29287462/enzymatic-esterification-of-acylglycerols-rich-in-omega-3-from-flaxseed-oil-by-an-immobilized-solvent-tolerant-lipase-from-actinomadura-sediminis-utmc-2870-isolated-from-oil-contaminated-soil
#5
Somaye Imanparast, Javad Hamedi, Mohammad Ali Faramarzi
Polyunsaturated fatty acids (PUFAs) are essential to human health and can be produced by enzymatic esterification. Actinomadura sediminis UTMC 2870 isolated from oil-contaminated soil contained a lipase that was stable at varying pH and in various solvents, salts, and chemicals. This lipase exhibited high efficiency for omega-3 (n-3), and its production was optimized using a response surface method. Acylglycerols (AGs) rich in n-3 were produced by extraction of the free fatty acids (FFAs) from flaxseed oil, concentration of PUFAs, and enzymatic esterification by the Celite-immobilized lipase...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29274984/production-milk-and-plasma-fatty-acid-profile-and-nutrient-utilization-in-jersey-cows-fed-flaxseed-oil-and-corn-grain-with-different-particle-size
#6
V Brossillon, S F Reis, D C Moura, J G B Galvão, A S Oliveira, C Côrtes, A F Brito
We aimed to compare the effects of ground (GC) or cracked corn (CC), with or without flaxseed oil (FSO), on milk yield, milk and plasma fatty acid (FA) profile, and nutrient digestibility in Jersey cows fed diets formulated to contain similar starch concentrations. Twelve multiparous organic-certified Jersey cows averaging (mean ± standard deviation) 455 ± 41.9 kg of body weight and 152 ± 34 d in milk and 4 primiparous organic-certified Jersey cows averaging (mean ± standard deviation) 356 ± 2.41 kg of body weight and 174 ± 30 d in milk in the beginning of the experiment were used...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29274976/replacing-ground-corn-with-incremental-amounts-of-liquid-molasses-does-not-change-milk-enterolactone-but-decreases-production-in-dairy-cows-fed-flaxseed-meal
#7
C P Ghedini, D C Moura, R A V Santana, A S Oliveira, A F Brito
We investigated the effects of replacing ground corn (GRC) with incremental amounts of liquid molasses (LM) on milk enterolactone concentration, antioxidant enzymes activity in plasma, production, milk fatty acid (FA) profile, and nutrient utilization in Jersey cows fed flaxseed meal and low-starch diets. Sixteen multiparous organically certified Jersey cows averaging (mean ± standard deviation) 101 ± 45 d in milk, 462 ± 38 kg of body weight, and 19.8 ± 3.90 kg/d of milk in the beginning of the study were randomly assigned to treatment sequences in a replicated 4 × 4 Latin square design, with 14 d for diet adaptation and 7 d for data and sample collection...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29273328/elevation-of-serum-pyruvate-kinase-m2-pkm2-in-ibd-and-its-relationship-to-ibd-indices
#8
Ahmed A Almousa, Marc Morris, Sharyle Fowler, Jennifer Jones, Jane Alcorn
OBJECTIVES: Endoscopy remains the gold standard to diagnose and evaluate inflammatory bowel disease (IBD) activity. Current biomarkers or their combinations cannot adequately predict IBD risk, diagnosis, progression or relapse, and response to therapy. Pyruvate kinase M2 (PKM2) is emerging as a significant mediator of the inflammatory process. We aim to assess levels of serum PKM2 in healthy and newly diagnosed IBD patients and its relationship with IBD indices and microbiota changes...
December 19, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29245212/case-report-a-first-case-of-flaxseed-induced-anaphylaxis-in-korea
#9
Yewon Kang, So-Young Park, Soomin Noh, Jinyoung Kim, Bomi Seo, Oh Young Kwon, Hyouk-Soo Kwon, You Sook Cho, Hee-Bom Moon, Tae-Bum Kim
RATIONALE: Anaphylaxis is a serious, generalized allergic reaction typically triggered by drugs, food, and bee venom, which can be life-threatening. Seeds are one of the major food allergens and can cause anaphylaxis as well as systemic hypersensitivity reactions. Flaxseed has been widely used crop for numerous purposes, such as in alternative medicine and as a dietary supplement, hypersensitivity to it has rarely been reported. PATIENT CONCERNS: A 42-year-old female presenting with facial edema, dyspnea and urticaria after ingested half teaspoon of flaxseed flour 30 minutes previously...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29229363/comparison-of-the-effects-of-flaxseed-oil-and-sunflower-seed-oil-consumption-on-serum-glucose-lipid-profile-blood-pressure-and-lipid-peroxidation-in-patients-with-metabolic-syndrome
#10
Atefeh Akrami, Farzad Nikaein, Siavash Babajafari, Shiva Faghih, Hassan Yarmohammadi
BACKGROUND: Metabolic syndrome (MetSyn) increases the risk of type II diabetes and morbidity and mortality due to cardiovascular diseases. Flaxseed oil (FO), as a functional food, is one of the major vegetal sources of essential omega-3 fatty acids. OBJECTIVE: This study aimed to compare the effects of consumption of FO and sunflower seed oil (SO) on lipid peroxidation and other symptoms of MetSyn. METHODS: This randomized controlled interventional trial was conducted on 60 volunteers aged 30 to 60 years who were diagnosed with MetSyn in Shiraz, Iran...
November 20, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29228348/flaxseed-supplementation-on-glucose-control-and-insulin-sensitivity-a-systematic-review-and-meta-analysis-of-25-randomized-placebo-controlled-trials
#11
Mohsen Mohammadi-Sartang, Zahra Sohrabi, Reza Barati-Boldaji, Hamidreza Raeisi-Dehkordi, Zohreh Mazloom
Context: The results of human clinical trials investigating the effects of flaxseed on glucose control and insulin sensitivity are inconsistent. Objective: The present study aimed to systematically review and analyze randomized controlled trials assessing the effects of flaxseed consumption on glycemic control. Data Sources: PubMed, Medline via Ovid, SCOPUS, EMBASE, and ISI Web of Sciences databases were searched up to November 2016. Study Selection: Clinical trials in which flaxseed or its products were administered as an intervention were included...
December 8, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29187002/the-influence-of-a-diet-based-on-flaxseed-an-omega-3-source-during-different-developmental-periods-on-the-blood-pressure-of-rats-submitted-to-stress
#12
Juliana Azevedo de Meneses, Liana de Araújo Trugilho, Samantha de Aguiar Lima, Amanda Carneiro Ferreira Freitas, Henrique Saldanha Melo, Maitê Rocha Ferreira, Luis Guillermo Coca Velarde, Felipe Zandonadi Brandão, Gabrielle de Souza Rocha, Gilson Teles Boaventura
OBJECTIVE: This study aimed to investigate a flaxseed diet during different developmental periods, and its effect on the blood pressure of rats submitted to stress. METHODS: Fifty six male rats (F1), born from 14 rats (F0), were divided into 7 groups (n = 8): flaxseed group (FG); Flaxseed group gestation and lactation (FG-GL); Flaxseed group weaning (FG-W); Flaxseed group weaning and stress (FG-WS); Flaxseed group stress (FG-S); Flaxseed group gestation lactation and weaning (FG-GLW) and Control Group (CG)...
November 29, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29175142/flaxseed-oil-rich-in-omega-3-protects-aorta-against-inflammation-and-endoplasmic-reticulum-stress-partially-mediated-by-gpr120-receptor-in-obese-diabetic-and-dyslipidemic-mice-models
#13
Alexandre Moura-Assis, Milessa Silva Afonso, Vanessa de Oliveira, Joseane Morari, Gustavo Aparecido Dos Santos, Marcia Koike, Ana Maria Lottenberg, Rodrigo Ramos Catharino, Licio Augusto Velloso, Adelino Sanchez Ramos da Silva, L P de Moura, Eduardo Rochete Ropelle, José Rodrigo Pauli, Dennys Esper Corrêa Cintra
The "first hit" to atherogenesis is driven by toll-like receptor 4, endoplasmic reticulum stress and ultimately metabolic dysfunction. In this study, we hypothesized that a flaxseed oil-enriched diet (FS) abolishes these inflammatory signaling pathway and restore metabolic homeostasis by activating the fatty acid receptor GPR120 in aorta of obese mice. Glucose homeostasis was assessed by GTT and ITT; lipidomics was performed using a Hybrid Ion Trap-Orbitrap Mass Spectrometer; serum lipids were measured using colorimetric assays; GPR120 and infiltrating macrophages were analyzed by immunofluorescence; protein immunoprecipitation and gene expression were evaluated by Western blot and RT-PCR, respectively...
October 18, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29174150/short-communication-decreasing-the-dietary-ratio-of-omega-6-to-omega-3-fatty-acids-increases-the-omega-3-concentration-of-peripheral-blood-mononuclear-cells-in-weaned-holstein-heifer-calves
#14
L C Worden, M G Erickson, S Gramer, C Tap, C Ylioja, N Trottier, C L Preseault, M J VandeHaar, A L Lock, E L Karcher
Utilization of nutrients to improve overall heifer health is of interest because of the importance of replacement heifers to the dairy industry. The objective of our study was to compare the effect of supplementation of dietary n-3 and n-6 fatty acids (FA) on FA concentrations in peripheral blood mononuclear cells (PBMC) of Holstein calves. Twenty-seven Holstein heifer calves (107 ± 2.6 d of age; 142.6 ± 6.5 kg of body weight) from the university research and teaching herd were randomly assigned to a common TMR supplemented with 1 of 3 treatments: Ca salts of flaxseed FA (Virtus Nutrition, Corcoran, CA) containing 35% 18:3 n-3 (N3), Ca salts of soybean FA (Virtus Nutrition) containing 50% 18:2 n-6 (N6), or a 50:50 mix of N3 and N6...
November 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29174030/position-paper-on-vegetarian-diets-from-the-working-group-of-the-italian-society-of-human-nutrition
#15
C Agnoli, L Baroni, I Bertini, S Ciappellano, A Fabbri, M Papa, N Pellegrini, R Sbarbati, M L Scarino, V Siani, S Sieri
BACKGROUND: Interest in vegetarian diets is growing in Italy and elsewhere, as government agencies and health/nutrition organizations are emphasizing that regular consumption of plant foods may provide health benefits and help prevent certain diseases. METHODS AND RESULTS: We conducted a Pubmed search, up to September, 2015, for studies on key nutrients (proteins, vitamin B12, iron, zinc, calcium, vitamin D, and n-3 fatty acids) in vegetarian diets. From 295 eligible publications the following emerged: Vegetarians should be encouraged to supplement their diets with a reliable source of vitamin B12 (vitamin-fortified foods or supplements)...
October 31, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29167527/the-effects-of-diets-enriched-in-omega-3-polyunsaturated-fatty-acids-on-systemic-vaccinia-virus-infection
#16
Gwendolyn J B Jones, Rachel L Roper
Omega-3 polyunsaturated fatty acids (PUFA, n-3 fatty acids), the key components of fish and flaxseed oils, are increasingly consumed by the public because of their potential health benefits and are available by prescription for hypertriglyceridemia. However, numerous studies have shown that these compounds are immunoregulatory and immunosuppressive and thus may increase susceptibility to infection. In this study, we tested the effects of the amount of fat and the types of fatty acid in the diet on infection by vaccinia virus, an acute infection that begins in the respiratory tract and spreads by viremia to internal organs...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29143841/ionic-liquids-as-stationary-phases-for-fatty-acid-analysis-by-gas-chromatography
#17
REVIEW
C Fanali, G Micalizzi, P Dugo, L Mondello
The present paper provides an overview of the application of ionic liquid (IL) columns for GC analysis of fatty acid methyl esters (FAMEs). Although their separation can be carried out utilizing GC columns containing polar stationary phases, some ILs have been employed as stationary phases, either commercial or laboratory made, in GC analysis. Monodimensional and bidimensional GC methods have been optimized in order to achieve the best separation especially considering the geometric and positional isomers of unsaturated fatty acids...
November 16, 2017: Analyst
https://www.readbyqxmd.com/read/29117618/the-effects-of-flaxseed-oil-omega-3-fatty-acids-supplementation-on-metabolic-status-of-patients-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#18
Golara Mirmasoumi, Mohammad Fazilati, Fatemeh Foroozanfard, Zahra Vahedpoor, Samaneh Mahmoodi, Mohsen Taghizadeh, Nazanin Kazemi Esfeh, Maryam Mohseni, Hassan Karbassizadeh, Zatollah Asemi
Objective This study was conducted to evaluate the effects of flaxseed oil omega-3 fatty acids supplementation on metabolic status of patients with polycystic ovary syndrome (PCOS). Methods This randomized double-blind, placebo-controlled trial was conducted on 60 women with PCOS according to the Rotterdam criteria aged 18-40 years old. Participants were randomly assigned into two groups to receive either 1,000 mg flaxseed oil omega-3 fatty acids (n=30) or placebo (n=30) twice a day for 12 weeks. Metabolic, endocrine, inflammatory factors were quantified at baseline and after the 12-week intervention...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29116353/use-of-qnmr-for-speciation-of-flaxseeds-linum-usitatissimum-and-quantification-of-cyanogenic-glycosides
#19
Romain Roulard, Jean-Xavier Fontaine, Arash Jamali, Dominique Cailleu, Reynald Tavernier, Xavier Guillot, Larbi Rhazi, Emmanuel Petit, Roland Molinie, François Mesnard
This report describes a routine method taking less than 20 min to quantify cyanogenic glycosides such as linustatin and neolinustatin from flaxseeds (Linum usitatissimum L.) using (1)H nuclear magnetic resonance. After manual dehulling, a higher linustatin content was shown in the almond fraction, while neolinustatin and total cyanogenic glycoside contents were significantly higher in hulls. Linustatin and neolinustatin were quantified in seven cultivars grown in two locations in three different years. Linustatin, neolinustatin, and total cyanogenic glycosides ranged between 91 and 267 mg/100 g, 78-272 mg/100 g, and 198-513 mg/100 g dry weight flaxseeds, respectively...
November 7, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29114553/compare-the-effect-of-flaxseed-evening-primrose-oil-and-vitamin-e-on-duration-of-periodic-breast-pain
#20
Farzaneh Jaafarnejad, Elham Adibmoghaddam, Seyyed Ahmad Emami, Azadeh Saki
BACKGROUND: Breast periodic pain is the most common disorder of the breast which leads to consultation with knowledgeable people like a midwife. The aim of this study was to compare the therapeutic effect of flaxseed, evening primrose oil, and Vitamin E on the duration of the period of breast pain. MATERIALS AND METHODS: This study is a quasi-randomized clinical trial conducted in 2015 on ninety patients complaining of breast periodic pain referring to Gynecologic Clinics of Ghaem Hospital or residents living in dormitories of Mashhad University of Medical Sciences...
2017: Journal of Education and Health Promotion
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