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https://www.readbyqxmd.com/read/28817724/from-the-animal-house-to-the-field-are-there-consistent-individual-differences-in-immunological-profile-in-wild-populations-of-field-voles-microtus-agrestis
#1
Elena Arriero, Klara M Wanelik, Richard J Birtles, Janette E Bradley, Joseph A Jackson, Steve Paterson, Mike Begon
Inbred mouse strains, living in simple laboratory environments far removed from nature, have been shown to vary consistently in their immune response. However, wildlife populations are typically outbreeding and face a multiplicity of challenges, parasitological and otherwise. In this study we seek evidence of consistent difference in immunological profile amongst individuals in the wild. We apply a novel method in this context, using longitudinal (repeated capture) data from natural populations of field voles, Microtus agrestis, on a range of life history and infection metrics, and on gene expression levels...
2017: PloS One
https://www.readbyqxmd.com/read/28817504/movement-demands-and-perceived-wellness-associated-with-pre-season-training-camp-in-ncaa-division-i-college-football-players
#2
Aaron D Wellman, Sam C Coad, Patrick J Flynn, Christopher P McLellan, Mike Climstein
The aims of the present study were to examine the movement demands of pre-season practice in National Collegiate Athletic Association (NCAA) division I college football players using portable global positioning system (GPS) technology and to assess perceived wellness associated with pre-season practice to determine if GPS-derived variables from the preceding day influence perceived wellness the following day. Twenty-nine players were monitored using GPS receivers (Catapult Innovations, Melbourne, Australia) during 20 pre-season practices...
July 5, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28815527/discovery-and-roles-of-er-endolysosomal-contact-sites-in-disease
#3
William Mike Henne
Inter-organelle membrane contact sites (MCSs) serve as unique microenvironments for the sensing and exchange of cellular metabolites and lipids. Though poorly defined, ER-endolysosomal contact sites are quickly becoming recognized as centers for inter-organelle lipid exchange and metabolic decision-making. Here, we review the discovery and current state of knowledge of ER-endolysosomal MCSs with particular focus on the molecular players that establish and/or utilize these contact sites in metabolism. We also discuss associations of ER-endolysosomal MCS-associated proteins in human disease, as well as the therapeutic promise these contact sites hold in modulating cellular physiology...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28815112/predicting-intervention-onset-in-the-icu-with-switching-state-space-models
#4
Marzyeh Ghassemi, Mike Wu, Michael C Hughes, Peter Szolovits, Finale Doshi-Velez
The impact of many intensive care unit interventions has not been fully quantified, especially in heterogeneous patient populations. We train unsupervised switching state autoregressive models on vital signs from the public MIMIC-III database to capture patient movement between physiological states. We compare our learned states to static demographics and raw vital signs in the prediction of five ICU treatments: ventilation, vasopressor administra tion, and three transfusions. We show that our learned states, when combined with demographics and raw vital signs, improve prediction for most interventions even 4 or 8 hours ahead of onset...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28814857/when-is-dual-bronchodilation-indicated-in-copd
#5
REVIEW
Mike Thomas, David Mg Halpin, Marc Miravitlles
Inhaled bronchodilator medications are central to the management of COPD and are frequently given on a regular basis to prevent or reduce symptoms. While short-acting bronchodilators are a treatment option for people with relatively few COPD symptoms and at low risk of exacerbations, for the majority of patients with significant breathlessness at the time of diagnosis, long-acting bronchodilators may be required. Dual bronchodilation with a long-acting β2-agonist and long-acting muscarinic antagonist may be more effective treatment for some of these patients, with the aim of improving symptoms...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28814316/evaluation-of-sarolaner-and-spinosad-oral-treatments-to-eliminate-fleas-reduce-dermatologic-lesions-and-minimize-pruritus-in-naturally-infested-dogs-in-west-central-florida-usa
#6
Michael W Dryden, Michael S Canfield, Emily Niedfeldt, Amanda Kinnon, Kimberly Kalosy, Amber Smith, Kaitlin M Foley, Vicki Smith, Todd S Bress, Nicole Smith, Mike Endrizzi, Joyce Login
BACKGROUND: An in-home investigation of naturally flea infested dogs was conducted in West Central Florida, USA to evaluate and compare the effectiveness of two different oral flea adulticides to control flea infestations, minimize dermatologic lesions and reduce pruritus over an 8-week period. METHODS: Twenty-nine dogs living in 19 homes and another 26 dogs residing in 16 different homes were orally administered either a sarolaner or spinosad chewable, respectively on day 0 and once between days 28-30...
August 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28813788/a-novel-pneumatic-stimulator-for-the-investigation-of-noise-enhanced-proprioception
#7
Anna-Maria Georgarakis, Harshal A Sonar, Mike D Rinderknecht, Olivier Lambercy, Bernard J Martin, Verena Klamroth-Marganska, Jamie Paik, Robert Riener, Jaime E Duarte
Executing coordinated movements requires that motor and sensory systems cooperate to achieve a motor goal. Impairment of either system may lead to unstable and/or inaccurate movements. In rehabilitation training, however, most approaches have focused on the motor aspects of the control loop. We are examining mechanisms that may enhance the sensory system to improve motor control. More precisely, the effects of stochastic subliminal vibratory tactile stimulation on wrist proprioception. We developed a device - based on a novel soft pneumatic actuator skin technology - to stimulate multiple sites simultaneously and independently...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813041/supported-nickel-rhenium-catalysts-for-selective-hydrogenation-of-methyl-esters-to-alcohols
#8
Kaituo Liu, James Pritchard, Li Lu, Robbert van Putten, M W G M Tiny Verhoeven, Mike Schmitkamp, Xiaoming Huang, Laurent Lefort, Christopher J Kiely, Emiel J M Hensen, Evgeny A Pidko
The addition of Re to Ni on TiO2 yields efficient catalysts for the hydrogenation of acids and esters to alcohols under mild conditions. Rhenium promotes the formation of atomically dispersed and sub-nanometre-sized bimetallic species interacting strongly with the oxide support.
August 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28812697/fish-pool-their-experience-to-solve-problems-collectively
#9
Mike M Webster, Andrew Whalen, Kevin N Laland
Access to information is a key advantage of grouping. Although experienced animals can lead others to solve problems, less is known about whether partially informed individuals can pool experiences to overcome challenges collectively. Here we provide evidence of such 'experience-pooling'. We presented shoals of sticklebacks (Gasterosteus aculeatus) with a two-stage foraging task requiring them to find and access hidden food. Individual fish were either inexperienced or had knowledge of just one of the stages...
April 18, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812384/identification-of-risk-factors-associated-with-postoperative-acute-kidney-injury-after-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-a-retrospective-study
#10
Juan P Cata, Acsa M Zavala, Antoinette Van Meter, Uduak U Williams, Jose Soliz, Mike Hernandez, Pascal Owusu-Agyemang
BACKGROUND: Acute kidney injury (AKI) is a postoperative complication associated with significant morbidity and mortality. The incidence and risks factors for AKI after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) have not been fully studied. The purpose of this study was to identify perioperative risk factors predictive of AKI after CRS-HIPEC. METHODS: This retrospective study collected demographic, tumor-related, intraoperative and postoperative data from 475 patients who underwent CRS-HIPECs...
August 16, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28811750/availability-of-a-sports-dietitian-may-lead-to-improved-performance-and-recovery-of-ncaa-division-i-baseball-athletes
#11
Michael V Hull, Jonathan Neddo, Andrew R Jagim, Jonathan M Oliver, Mike Greenwood, Margaret T Jones
BACKGROUND: The purpose was to survey dietary habits (DH) and nutrient timing (NT) practices of baseball student-athletes (mean ± SD; 20.7 ± 1.4 yr.) from three NCAA Division I institutions, and examine the effect of a sports dietitian (SD) in regard to nutrition practices. METHODS: Descriptive statistics and Pearson X(2) analyses were run. Responses on 10 DH and 5 NT items differed (p ≤ 0.10) between athletes who sought dietary planning from a SD (n = 36) versus those who consulted a strength and conditioning coach (SCC, n = 42)...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28810404/sexual-orientation-bullying-for-being-labeled-gay-or-bisexual-and-steroid-use-among-us-adolescent-boys
#12
Mike C Parent, Tyler C Bradstreet
Use of anabolic-androgenic steroids is a public health concern for adolescent boys. This study examined bullying based on being labeled gay/bisexual and steroid use among US adolescent boys, including sexual orientation disparities. Data from 2660 boys from the 2015 Youth Behavior Risk Survey were used. Among heterosexual boys, steroid use was higher among those who reported being bullied due to being labeled gay or bisexual. No such relationship existed among non-heterosexual boys. The results speak to the need to address issues of masculinity in clinical work with boys and young men...
February 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28810364/identifying-barriers-to-help-seeking-for-non-motor-symptoms-in-people-with-parkinson-s-disease
#13
Catherine S Hurt, Lorna Rixon, K Ray Chaudhuri, Rona Moss-Morris, Mike Samuel, Richard G Brown
Non-motor symptoms of Parkinson's disease have a significant impact on quality of life. Despite this, many non-motor symptoms remain unreported by patients and consequently untreated. This study explored barriers to help-seeking using two theoretical frameworks, the Common Sense Model of illness perception and Theoretical Domains Framework. A total of 20 participants completed semi-structured interviews to explore symptom beliefs and help-seeking behaviour. Uncertainty about the relationship of non-motor symptoms to Parkinson's disease and lack of clarity around treatments were common...
December 1, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/28808077/gps-knowledge-use-and-confidence-in-national-physical-activity-and-health-guidelines-and-tools-a-questionnaire-based-survey-of-general-practice-in-england
#14
Robin Chatterjee, Tim Chapman, Mike Gt Brannan, Justin Varney
BACKGROUND: Physical activity (PA) brief advice in health care is effective at getting individuals active. It has been suggested that one in four people would be more active if advised by a GP or nurse, but as many as 72% of GPs do not discuss the benefits of physical activity with patients. AIM: To assess the knowledge, use, and confidence in national PA and Chief Medical Officer (CMO) health guidelines and tools among GPs in England. DESIGN AND SETTING: Online questionnaire-based survey of selfselecting GPs in England that took place over a 10-day period in March 2016...
August 14, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28807835/the-role-of-antimicrobial-stewardship-programmes-in-children-a-systematic-review
#15
REVIEW
André Ricardo Araujo da Silva, Déborah Cardoso Albernaz de Almeida Dias, Amanda Fáris Marques, Clara Biscaia di Biase, Indah K Murni, Angela Dramowski, Mike Sharland, Johanes Huebner, Walter Zingg
The United Nations and the World Health Organization have designated antimicrobial resistance (AMR) as a major health priority and developed action plans to reduce AMR in all healthcare settings. Establishment of institutional antimicrobial stewardship programmes (ASPs) is advocated as a key intervention to reduce antibiotic consumption in hospitals and address high rates of multi-drug resistant (MDR) bacteria. We searched PUBMED and the Cochrane database of systematic reviews (1/2007-3/2017) to identify studies reporting about the effectiveness of ASPs in general paediatric wards and paediatric intensive care units (PICU), on reducing antibiotic consumption, on using broad spectrum/restricted antibiotics, and on antibiotic resistance and healthcare-associated infections (HAIs)...
August 11, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28807157/antiinflammatory-and-hepatoprotective-medicinal-herbs-as-potential-substitutes-for-bear-bile
#16
Sandra Appiah, Mike Revitt, Huw Jones, Milan Vu, Monique Simmonds, Celia Bell
Practitioners of traditional Chinese medicine (TCM) commonly prescribe medicinal formulations relying on the purported synergism of a combination of plant species, sometimes incorporating animal parts and minerals. Bear bile, obtained from either wild or farmed bears, is a commonly used constituent of traditional medicine formulations. With several bear species now listed under Convention on International Trade in Endangered Species of Wild Fauna and Flora as threatened with extinction and with bear farming being actively campaigned against on ethical grounds, it is important to seek and promote alternatives to the use of bear bile as medicine...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28806588/measurement-of-side-effects-of-anti-epileptic-drugs-aeds-in-adults-with-intellectual-disability-a-systematic-review
#17
REVIEW
Lauren Copeland, Andrea Meek, Mike Kerr, Michael Robling, Kerry Hood, Rachel McNamara
No abstract text is available yet for this article.
July 27, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28805794/large-scale-mapping-of-cortical-synaptic-projections-with-extracellular-electrode-arrays
#18
Mark Shein-Idelson, Lorenz Pammer, Mike Hemberger, Gilles Laurent
Understanding circuit computation in the nervous system requires sampling activity over large neural populations and maximizing the number of features that can be extracted. By combining planar arrays of extracellular electrodes with the three-layered cortex of turtles, we show that synaptic signals induced along individual axons as well as action potentials can be easily captured. Two types of information can be extracted from these signals, the neuronal subtype (inhibitory or excitatory)-whose identification is more reliable than with traditional measures such as action potential width-and a (partial) spatial map of functional axonal projections from individual neurons...
August 14, 2017: Nature Methods
https://www.readbyqxmd.com/read/28804786/health-impact-assessment-of-the-uk-soft-drinks-industry-levy-a-comparative-risk-assessment-modelling-study
#19
Adam D M Briggs, Oliver T Mytton, Ariane Kehlbacher, Richard Tiffin, Ahmed Elhussein, Mike Rayner, Susan A Jebb, Tony Blakely, Peter Scarborough
BACKGROUND: In March, 2016, the UK Government proposed a tiered levy on sugar-sweetened beverages (SSBs; high tax for drinks with >8 g of sugar per 100 mL, moderate tax for 5-8 g, and no tax for <5 g). We estimate the effect of possible industry responses to the levy on obesity, diabetes, and dental caries. METHODS: We modelled three possible industry responses: reformulation to reduce sugar concentration, an increase of product price, and a change of the market share of high-sugar, mid-sugar, and low-sugar drinks...
January 2017: Lancet. Public Health
https://www.readbyqxmd.com/read/28803526/familiarity-and-within-person-facial-variability-the-importance-of-the-internal-and-external-features
#20
Robin S S Kramer, Zoi Manesi, Alice Towler, Michael G Reynolds, A Mike Burton
As faces become familiar, we come to rely more on their internal features for recognition and matching tasks. Here, we assess whether this same pattern is also observed for a card sorting task. Participants sorted photos showing either the full face, only the internal features, or only the external features into multiple piles, one pile per identity. In Experiments 1 and 2, we showed the standard advantage for familiar faces-sorting was more accurate and showed very few errors in comparison with unfamiliar faces...
January 1, 2017: Perception
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