keyword
MENU ▼
Read by QxMD icon Read
search

NK cells

keyword
https://www.readbyqxmd.com/read/29222872/comparison-of-therapeutic-effects-of-egfr-tyrosine-kinase-inhibitors-on-19del-and-l858r-mutations-in-advanced-lung-adenocarcinoma-and-effect-on-cellular-immune-function
#1
Juan Zhou, Suqin Ben
BACKGROUND: We compared the therapeutic effect of EGFR-tyrosine kinase inhibitors (TKIs) on 19Del and L858R mutations in advanced lung adenocarcinoma on cellular immune function and explored the factors influencing the curative effect and prognosis. METHODS: Clinical efficacy in the selected 71 patients with lung adenocarcinoma, including 52 patients with 19Del and L858R mutations and 19 wild type patients treated with EGFR-TKIs was retrospectively analyzed. The response rate (RR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and cellular immune function were analyzed...
December 9, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/29222435/long-term-maintenance-of-peripheral-blood-derived-human-nk-cells-in-a-novel-human-il-15-transgenic-nog-mouse
#2
Ikumi Katano, Chiyoko Nishime, Ryoji Ito, Tsutomu Kamisako, Takuma Mizusawa, Yuyo Ka, Tomoyuki Ogura, Hiroshi Suemizu, Yutaka Kawakami, Mamoru Ito, Takeshi Takahashi
We generated a novel mouse strain expressing transgenic human interleukin-15 (IL-15) using the severe immunodeficient NOD/Shi-scid-IL-2Rγ null (NOG) mouse genetic background (NOG-IL-15 Tg). Human natural killer (NK) cells, purified from the peripheral blood (hu-PB-NK) of normal healthy donors, proliferated when transferred into NOG-IL-15 Tg mice. In addition, the cell number increased, and the hu-PB-NK cells persisted for 3 months without signs of xenogeneic graft versus host diseases (xGVHD). These in vivo-expanded hu-PB-NK cells maintained the original expression patterns of various surface antigens, including NK receptors and killer cell immunoglobulin-like receptor (KIR) molecules...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222389/natural-killer-cells-and-t-lymphocytes-in-pregnancy-and-pre-eclampsia
#3
EDITORIAL
Erin B Taylor, Jennifer M Sasser
Although pre-eclampsia (PE), a hypertensive disorder of pregnancy, has significant maternal and fetal morbidity and mortality worldwide, the mechanisms contributing to this disease have not been fully elucidated. Studies in patients and experimental models have shown that changes in the number or function of immune cells of both the adaptive and innate immune systems contribute to the development and pathogenesis of PE. This commentary summarizes our current understanding of the role of the immune system in the pathogenesis of PE, specifically focussing on dysfunction of natural killer (NK) cells and T lymphocyte populations...
December 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29222089/core-binding-factor-%C3%AE-and-runx-transcription-factors-promote-adaptive-natural-killer-cell-responses
#4
Moritz Rapp, Colleen M Lau, Nicholas M Adams, Orr-El Weizman, Timothy E O'Sullivan, Clair D Geary, Joseph C Sun
Natural killer (NK) cells are innate lymphocytes that have features of adaptive immunity such as clonal expansion and generation of long-lived memory. Interleukin-12 (IL-12) signaling through its downstream transcription factor signal transducer and activator of transcription 4 (STAT4) is required for the generation of memory NK cells after expansion. We identify gene loci that are highly enriched for STAT4 binding using chromatin immunoprecipitation sequencing for STAT4 and the permissive histone mark H3K4me3 in activated NK cells...
December 8, 2017: Science Immunology
https://www.readbyqxmd.com/read/29221953/antitumor-action-of-3-bromopyruvate-implicates-reorganized-tumor-growth-regulatory-components-of-tumor-milieu-cell-cycle-arrest-and-induction-of-mitochondria-dependent-tumor-cell-death
#5
Saveg Yadav, Praveen Kumar Kujur, Shrish Kumar Pandey, Yugal Goel, Babu Nandan Maurya, Ashish Verma, Ajay Kumar, Rana Pratap Singh, Sukh Mahendra Singh
Evidences demonstrate that metabolic inhibitor 3-bromopyruvate (3-BP) exerts a potent antitumor action against a wide range of malignancies. However, the effect of 3-BP on progression of the tumors of thymic origin remains unexplored. Although, constituents of tumor microenvironment (TME) plays a pivotal role in regulation of tumor progression, it remains unclear if 3-BP can alter the composition of the crucial tumor growth regulatory components of the external surrounding of tumor cells. Thus, the present investigation attempts to understand the effect of 3-BP administration to a host bearing a progressively growing tumor of thymic origin on tumor growth regulatory soluble, cellular and biophysical components of tumor milieu vis-à-vis understanding its association with tumor progression, accompanying cell cycle events and mode of cell death...
December 5, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29221684/ex-vivo-flush-of-the-limb-allograft-reduces-inflammatory-burden-prior-to-transplantation
#6
Kavit R Amin, Alexandra L Ball, Chandanpreet Chhina, Rebecca J Edge, John P Stone, William R Critchley, Jason K Wong, James E Fildes
BACKGROUND: Passenger leucocytes and inflammatory debris transferred from the donor limb to the recipient can induce allorecognition, which activates the host immune response. This is the first study to evaluate whether the transfer of this inflammatory burden can be reduced via post-preservation flush prior to revascularisation, and whether this is influenced by ischaemia. METHODS: Bilateral forelimbs from the same pig were procured and infused with preservation flush and stored on ice...
November 24, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29221433/hyporesponsiveness-of-natural-killer-cells-and-impaired-inflammatory-responses-in-critically-ill-patients
#7
Minkyung Kim, Minjoo Kim, Hana Jeong, Jey Sook Chae, Young Sam Kim, Jae Gil Lee, Younsoo Cho, Jong Ho Lee
BACKGROUND: To investigate natural killer (NK) cell activity, circulating cytokine level and peripheral blood mononuclear cell (PBMC) cytokine production status in critically ill patients. METHODS: Blood samples were collected <24 h after admission from 24 intensive care unit (ICU) patients and 24 age-, sex-, and body mass index (BMI)-matched healthy controls. Serum cytokine concentrations and cytokine production by PBMCs and lipopolysaccharide (LPS)-stimulated PBMCs were measured...
December 8, 2017: BMC Immunology
https://www.readbyqxmd.com/read/29220536/cd36-deficiency-attenuates-immune-mediated-hepatitis-in-mice-by-modulating-the-proapoptotic-effects-of-cxcl10
#8
Che Xu, Chen Zhang, Jie Ji, Chao Wang, Jing Yang, Biao Geng, Ting Zhao, Hong Zhou, Xianmin Mu, Jinshun Pan, Shi Hu, Yuanfang Lv, Xingguo Chen, Hao Wen, Qiang You
The scavenger receptor, CD36, recognizes a diverse set of ligands, and has been implicated in a wide variety of normal and pathological processes, including lipid metabolism, angiogenesis, atherosclerosis, and phagocytosis. In particular, recent findings have demonstrated its crucial functions in sterile inflammation and tumor metastasis. However, the role of CD36 in immune-mediated hepatitis remains unclear. Concanavalin A (Con A)-induced liver injury is a well-established experimental T cell-mediated hepatitis...
December 8, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29220498/nkg2c-deletion-is-a-risk-factor-for-human-cytomegalovirus-viremia-and-disease-after-lung-transplantation
#9
Hannes Vietzen, Karin Pollak, Claudia Honsig, Peter Jaksch, Elisabeth Puchhammer-Stöckl
Human cytomegalovirus (HCMV) replication is limited by HCMV-specific natural-killer (NK) cell response. Distinct genetic polymorphisms, which are potentially involved in antiviral NK-cell response, have been described. Here, the association between polymorphisms at IgG1 GM3/17, FcγRIIIα/CD16a-158V/F, NKG2Cwt/del, CD226/rs727088 and rs763361, respectively, and HCMV-viremia and disease was investigated in 98 lung transplant recipients (LTRs), within 9 months after stop of post-transplant HCMV-prophylaxis. From all variants, only the NKG2Cwt/wt genotype was significantly associated with freedom from HCMV-viremia (P= 0...
December 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29220122/expression-profile-analysis-of-long-noncoding-rna-in-acute-myeloid-leukemia-by-microarray-and-bioinformatics
#10
Yuandong Feng, Ying Shen, Hongli Chen, Xiaman Wang, Ru Zhang, Yue Peng, Xiaoru Lei, Tian Liu, Jing Liu, Liufang Gu, Fangxia Wang, Yun Yang, Ju Bai, Jianli Wang, Wanhong Zhao, Aili He
Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides, which are involved in tumorigenesis and play a key role in cancer progression. To determine whether lncRNAs are involved in acute myeloid leukemia (AML), we analyzed the expression profile of lncRNAs and mRNAs in AML. 5 pairs of AML patients and iron deficiency anemia (IDA) controls were screened by microarray. Through co-expression analysis, differently expressed transcripts were done into modules, and lncRNAs got the functional annotations...
December 8, 2017: Cancer Science
https://www.readbyqxmd.com/read/29218366/haploidentical-natural-killer-cells-induce-remissions-in-non-hodgkin-lymphoma-patients-with-low-levels-of-immune-suppressor-cells
#11
Veronika Bachanova, Dhifaf Sarhan, Todd E DeFor, Sarah Cooley, Angela Panoskaltsis-Mortari, Bruce R Blazar, Julie M Curtsinger, Linda Burns, Daniel J Weisdorf, Jeffrey S Miller
We report a novel phase 2 clinical trial in patients with poor prognosis refractory non-Hodgkin lymphoma (NHL) testing the efficacy of haploidentical donor natural killer (NK) cell therapy (NK dose 0.5-3.27 × 107 NK cells/kg) with rituximab and IL-2 (clinicaltrials.gov NCT01181258). Therapy was tolerated without graft-versus-host disease, cytokine release syndrome, or neurotoxicity. Of 14 evaluable patients, 4 had objective responses (29%; 95% CI 12-55%) at 2 months: 2 had complete response lasting 3 and 9 months...
December 7, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29218028/the-folate-cycle-as-a-cause-of-natural-killer-cell-dysfunction-and-viral-etiology-in-type-1-diabetes
#12
Allison L Bayer, Christopher A Fraker
The folate pathway is critical to proper cellular function and metabolism. It is responsible for multiple functions, including energy (ATP) production, methylation reactions for DNA and protein synthesis and the production of immunomodulatory molecules, inosine and adenosine. These play an important role in immune signaling and cytotoxicity. Herein, we hypothesize that defects in the folate pathway in genetically susceptible individuals could lead to immune dysfunction, permissive environments for chronic cyclical latent/lytic viral infection, and, ultimately, the development of unchecked autoimmune responses to infected tissue, in this case islet beta cells...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29215298/echinacea-purpurea-protects-against-restraint-stress-induced-immunosuppression-in-balb-c-mice
#13
Seonyoung Park, Mak-Soon Lee, Sunyoon Jung, Seohyun Lee, Oran Kwon, Matthias Heinrich Kreuter, Tania Perrinjaquet-Moccetti, Bokkee Min, Seong Ho Yun, Yangha Kim
Echinacea purpurea has been widely used for the prevention and treatment of upper respiratory tract infections and the common cold. The restraint stress has been reported to suppress a broad spectrum of immune functions. The aim of this study was to investigate the protective effects of the pressed juice of E. purpurea (L.) Moench (EFLA®894; Echinacea) against restraint stress-induced immunosuppression in BALB/c mice. Echinacea significantly normalized the restraint stress-induced reduction in splenocyte proliferation and splenic natural killer (NK) cell activity (P < ...
December 7, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29214185/administration-of-rhodiola-kirilowii-extracts-during-mouse-pregnancy-and-lactation-stimulates-innate-but-not-adaptive-immunity-of-the-offspring
#14
Sławomir Lewicki, Ewa Skopińska-Różewska, Aleksandra Brewczyńska, Robert Zdanowski
The use of antibiotics during pregnancy and lactation is associated with an increased risk of developmental disorders. One of the natural medicinal plants-Rhodiola kirilowii, widely used as an immunostimulant in adults-might be a good alternative to antibiotic treatment. The aim of present study was to assess whether daily oral administration of 20 mg/kg of Rhodiola kirilowii aqueous (RKW) or 50% hydroalcoholic (RKW-A) extracts affected hematological and immunological parameters of 6-week-old mouse progeny...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29213284/circulatory-immune-cells-in-cushing-syndrome-bystanders-or-active-contributors-to-atherometabolic-injury-a-study-of-adhesion-and-activation-of-cell-surface-markers
#15
Gloria Aranda, Cristina Lopez, Rebeca Fernandez-Ruiz, Yaiza Esteban, Guillermo Garcia-Eguren, Mireia Mora, Irene Halperin, Gregori Casals, Joaquim Enseñat, Felicia A Hanzu
Glucocorticoids (GC) induce cardiometabolic risk while atherosclerosis is a chronic inflammation involving immunity. GC are immune suppressors, and the adrenocorticotrophic hormone (ACTH) has immune modulator activities. Both may act in atherothrombotic inflammation involving immune cells (IMNC). Aim. To investigate adhesion and activation surface cell markers (CDs) of peripheral IMNC in endogenous Cushing syndrome (CS) and the immune modulator role of ACTH. Material and Methods. 16 ACTH-dependent CS (ACTH-D), 10 ACTH-independent (ACTH-ID) CS, and 16 healthy controls (C) were included...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29213274/natural-killer-cells-in-antifungal-immunity
#16
REVIEW
Stanislaw Schmidt, Lars Tramsen, Thomas Lehrnbecher
Invasive fungal infections are still an important cause of morbidity and mortality in immunocompromised patients such as patients suffering from hematological malignancies or patients undergoing hematopoietic stem cell transplantion. In addition, other populations such as human immunodeficiency virus-patients are at higher risk for invasive fungal infection. Despite the availability of new antifungal compounds and better supportive care measures, the fatality rate of invasive fungal infection remained unacceptably high...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29212951/glycolytic-requirement-for-nk-cell-cytotoxicity-and-cytomegalovirus-control
#17
Annelise Y Mah, Armin Rashidi, Molly P Keppel, Nermina Saucier, Emily K Moore, Joshua B Alinger, Sandeep K Tripathy, Sandeep K Agarwal, Emily K Jeng, Hing C Wong, Jeffrey S Miller, Todd A Fehniger, Emily M Mace, Anthony R French, Megan A Cooper
NK cell activation has been shown to be metabolically regulated in vitro; however, the role of metabolism during in vivo NK cell responses to infection is unknown. We examined the role of glycolysis in NK cell function during murine cytomegalovirus (MCMV) infection and the ability of IL-15 to prime NK cells during CMV infection. The glucose metabolism inhibitor 2-deoxy-ᴅ-glucose (2DG) impaired both mouse and human NK cell cytotoxicity following priming in vitro. Similarly, MCMV-infected mice treated with 2DG had impaired clearance of NK-specific targets in vivo, which was associated with higher viral burden and susceptibility to infection on the C57BL/6 background...
December 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/29212911/a-role-of-nkr-p1a-cd161-and-lectin-like-transcript-1-in-natural-cytotoxicity-against-human-articular-chondrocytes
#18
Agata Białoszewska, Joanna Olkowska-Truchanowicz, Katarzyna Bocian, Anna Osiecka-Iwan, Andrzej Czop, Claudine Kieda, Jacek Malejczyk
Normal cartilage cells are susceptible to lysis by NK cells. This phenomenon may play a role in immune cartilage destruction; however, the mechanisms of chondrocyte recognition by NK cells remain poorly understood. Therefore, the aim of this study was to reveal a possible role of NKR-P1A/lectin-like transcript 1 (LLT1) interaction in NK cell-mediated cytotoxicity against normal human articular chondrocytes. Chondrocytes were isolated from articular cartilage obtained during talonavicular joint surgery. PBMC or polyclonal NK cells isolated from normal donors served as effector cells...
December 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29212141/cytomegalovirus-pulls-strings-behind-nk-cells
#19
EDITORIAL
Norimitsu Kadowaki, Kenichi Ishiyama, Toshio Kitawaki
No abstract text is available yet for this article.
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211085/cancer-immunotherapy-%C3%AE-environment-labchip-taking-advantage-of-optoelectronic-tweezers
#20
Ling-Yi Ke, Zong-Keng Kuo, Yu-Shih Chen, Tsu-Yi Yeh, Minxiang Dong, Hsiang-Wen Tseng, Cheng-Hsien Liu
A cancer immunotherapy μ-environment LabChip, equipped with titanium oxide phthalocyanine (TiOPc)-based optoelectronic tweezers (OET) to achieve direct cell-cell contact, can be used to study the interaction between immune cells and other cells for real-time analysis of NK cells' behavior. In microfluidic devices, it is difficult to solve dead zone problems and observe dynamic cell-cell interactions. We have created a stable and static culture μ-environment which can enhance NK cell activities. In addition, OET is used to solve dead zone problems by manipulating a single cell into four-leaf-clover-shaped (FLCS) microwells made of poly(ethylene glycol) diacrylate (PEG-DA) through optofluidic maskless lithography, causing direct cell-cell contact...
December 6, 2017: Lab on a Chip
keyword
keyword
6934
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"