keyword
https://read.qxmd.com/read/37663712/delayed-awakening-and-its-associated-factor-following-general-anesthesia-service-2022-a-cross-sectional-study
#21
JOURNAL ARTICLE
Samuel D Bayable, Wubet D Amberbir, Melaku B Fetene
BACKGROUND: The time to emerge from anesthesia is affected by patient factors, anesthetic factors, the duration of surgery, and preoperative and intraoperative pain management. OBJECTIVE: This study aimed to determine the prevalence and contributing factors of delayed awakening following general anesthesia. METHOD: A cross-sectional study was conducted from January to June 2022. After getting ethical approval with the permission number S/C/R 37/01/2022, willing patients participate with written informed consent...
September 2023: Annals of Medicine and Surgery
https://read.qxmd.com/read/37565047/a-young-man-with-guillain-barr%C3%A3-syndrome-with-a-stroke-like-presentation-and-physical-findings-suggestive-of-cervical-myelopathy
#22
Maria Siddiqi, Sundus Sardar, Muhammad Ibrahim Alhatou
We describe the case of a 44-year-old gentleman with hypertension and asthma presenting to the emergency department after noticing right upper-extremity weakness upon awakening. Brain imaging did not reveal a stroke. Initial neurological examination pointed to cervical myelopathy with radiculopathy as well as possible underlying length-dependent peripheral neuropathy as there was right arm strength of 4/5 and there were brisker (3+) reflexes all over except at the right biceps reflex and both ankle reflexes...
2023: Qatar Medical Journal
https://read.qxmd.com/read/37537965/circadian-aspects-in-the-aetiology-and-pathophysiology-of-insomnia
#23
REVIEW
Leon C Lack, Gorica Micic, Nicole Lovato
Because the endogenous circadian pacemaker is a very strong determinant of alertness/sleep propensity across the 24 h period, its mistiming may contribute to symptoms of insomnia (e.g., difficulties initiating sleep and maintaining sleep) and to the development of insomnia disorder. Despite the separation of insomnia and circadian rhythm disorders in diagnostic nosology implying independent pathophysiology, there is considerable evidence of co-morbidity and interaction between them. Sleep onset insomnia is associated with later timed circadian rhythms and can be treated with morning bright light to shift rhythms to an earlier timing...
August 3, 2023: Journal of Sleep Research
https://read.qxmd.com/read/37516665/the-states-of-different-5-ht-receptors-located-in-the-dorsal-raphe-nucleus-are-crucial-for-regulating-the-awakening-during-general-anesthesia
#24
JOURNAL ARTICLE
HaiXiang Ma, LeYuan Gu, YuLing Wang, Qing Xu, Yuanli Zhang, WeiHui Shao, Qian Yu, XiTing Lian, Lu Liu, JiaXuan Gu, Na Ji, XiaoLing Liu, Kazuki Nagayasu, HongHai Zhang
General anesthesia is widely used in various clinical practices due to its ability to cause loss of consciousness. However, the exact mechanism of anesthesia-induced unconsciousness remains unclear. It is generally thought that arousal-related brain nuclei are involved. 5-Hydroxytryptamine (5-HT) is closely associated with sleep arousal. Here, we explore the role of the 5-HT system in anesthetic awakening through pharmacological interventions and optogenetic techniques. Our data showed that exogenous administration of 5-hydroxytryptophan (5-HTP) and optogenetic activation of 5-HT neurons in the dorsal raphe nucleus (DR) could significantly shorten the emergence time of sevoflurane anesthesia in mice, suggesting that regulation of the 5-HT system using both endogenous and exogenous approaches could mediate delayed emergence...
July 29, 2023: Molecular Neurobiology
https://read.qxmd.com/read/37464290/median-effective-dose-ed-50-of-esketamine-combined-with-propofol-for-children-to-inhibit-response-of-gastroscope-insertion
#25
JOURNAL ARTICLE
Ming Su, Yichao Zhu, Shupeng Liu, Lijuan Song, Jiangtao Qu, Yong Zhang, Quanyi Zhang
BACKGROUND: Propofol is the most commonly used drug for procedural sedation during gastroscopy. However, independent use of propofol can lead to increased dosage and additional side effects. Esketamine was found to be exceptional in combination with propofol for painless gastroscopy. No studies have calculated the median effective dose (ED50 ) of esketamine combined with propofol in pediatric painless gastroscopy. Here, we designed a research to study the ED50 of esketamine combined with propofol using the Dixon and Massey up-and-down sequential method for inhibiting the response of gastroscope insertion...
July 18, 2023: BMC Anesthesiology
https://read.qxmd.com/read/37463404/sleep-light-interventions-that-shift-melatonin-rhythms-earlier-improve-perimenopausal-and-postmenopausal-depression-preliminary-findings
#26
JOURNAL ARTICLE
Barbara L Parry, Charles J Meliska, Diane L Sorenson, L Fernando Martinez, Ana M Lopez, Sharron E Dawes, Jeffrey A Elliott, Richard L Hauger
OBJECTIVE: Testing the hypothesis that a sleep-light intervention, which phase-advances melatonin rhythms, will improve perimenopausal-postmenopausal (P-M; by follicle-stimulating hormone) depression. METHODS: In at-home environments, we compared two contrasting interventions: (1) an active phase-advance intervention: one night of advanced/restricted sleep from 9 pm to 1 am, followed by 8 weeks of morning bright white light for 60 min/d within 30 minutes of awakening, and (2) a control phase-delay intervention: one night of delayed/restricted sleep (sleep from 3 to 7 am) followed by 8 weeks of evening bright white light for 60 min/d within 90 minutes of bedtime...
July 18, 2023: Menopause: the Journal of the North American Menopause Society
https://read.qxmd.com/read/37438493/bioavailability-of-melatonin-after-administration-of-an-oral-prolonged-release-tablet-and-an-immediate-release-sublingual-spray-in-healthy-male-volunteers
#27
JOURNAL ARTICLE
Samira Ait Abdellah, Véronique Raverot, Caroline Gal, Isabelle Guinobert, Valérie Bardot, Claude Blondeau, Bruno Claustrat
BACKGROUND: The benefit of exogenous melatonin is based on its bioavailability, which depends on the galenic form, the route of administration, the dosage, and the individual absorption and rate of hepatic metabolism. OBJECTIVE: The objective of this study is to investigate the bioavailability of melatonin after administration of an oral prolonged-release tablet (PR form) and an immediate-release sublingual spray (IR form). The main metabolite of melatonin, 6-sulfatoxymelatonin (6-SMT), was also measured, which has not been done in previous studies...
July 12, 2023: Drugs in R&D
https://read.qxmd.com/read/37366126/-establishment-and-applicability-comparison-of-four-models-of-acute-liver-ischemia-reperfusion-injury-in-rat
#28
JOURNAL ARTICLE
Jiaqi Luo, Lili Wang, Fudong Chen, Aixian Zhang, Han Zhang, Xiaomeng Zhang, Li Chen
OBJECTIVE: To clarify the preparation methods of four rat models of liver ischemia/reperfusion injury (IRI) and to determine a liver IRI animal model that is consistent with clinical conditions, has stable pathological and physiological injury, and is easy to operate. METHODS: A total of 160 male Sprague-Dawley (SD) rats were randomly divided into four groups using an interval grouping method: 70% IRI (group A), 100% IRI (group B), 70% IRI with 30% hepatectomy (group C), and 100% IRI with 30% hepatectomy (group D), with 40 rats in each group...
June 2023: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/37296711/problems-in-the-development-of-the-sleep-wake-rhythm-influence-neurodevelopmental-disorders-in-children
#29
REVIEW
Kyoko Hoshino
Development of the sleep-wake rhythm has a significant effect on the physical and mental development of children. The sleep-wake rhythm is controlled by aminergic neurons in the brainstem's ascending reticular activating system, which is associated with synaptogenesis and the promotion of brain development. The sleep-wake rhythm develops rapidly within the first year after birth. At 3-4 months of age, the framework of the circadian rhythm is established. The objective of the present review is to assess a hypothesis concerning problems in the development of the sleep-wake rhythm and their effect on neurodevelopmental disorders...
May 26, 2023: Diagnostics
https://read.qxmd.com/read/37291651/effects-of-dexmedetomidine-at-different-dosages-on-perioperative-haemodynamics-and-postoperative-recovery-quality-in-elderly-patients-undergoing-hip-replacement-surgery-under-general-anaesthesia-a-randomized-controlled-trial
#30
JOURNAL ARTICLE
Haitong Liu, Mingjie Gao, Yongfeng Zheng, Caixia Sun, Qinyuan Lu, Donghua Shao
BACKGROUND: Dexmedetomidine could provide some advantages to prevent postoperative complications in elderly patients undergoing under general anaesthesia. However, dexmedetomidine inhibits haemodynamics to some extent due to its sympathetic inhibition. OBJECTIVE: To evaluate the effects of different doses of dexmedetomidine on haemodynamics during surgery and recovery after general anaesthesia in elderly patients undergoing hip replacement. METHODS: This was a prospective randomized double-blind controlled clinical trial...
June 8, 2023: Trials
https://read.qxmd.com/read/37274559/effect-of-modified-shengyangyiwei-decoction-on-painless-gastroscopy-and-gastrointestinal-and-immune-function-in-gastric-cancer-patients
#31
JOURNAL ARTICLE
Sui-Cai Mi, Ling-Yan Wu, Zheng-Jin Xu, Li-Yan Zheng, Jian-Wen Luo
BACKGROUND: Painless gastroenteroscopy is a widely developed diagnostic and treatment technology in clinical practice. It is of great significance in the clinical diagnosis, treatment, follow-up review and other aspects of gastric cancer patients. The application of anesthesia techniques during manipulation can be effective in reducing patient fear and discomfort. In clinical work, the adverse drug reactions of anesthesia regimens and the risk of serious adverse drug reactions are increased with the increase in propofol application dose application dose; the application of opioid drugs often causes gastrointestinal reactions, such as nausea, vomiting and delayed gastrointestinal function recovery, after examination...
May 16, 2023: World Journal of Gastrointestinal Endoscopy
https://read.qxmd.com/read/37251531/-central-anticholinergic-neuroleptic-malignant-and-serotonin-syndromes
#32
REVIEW
Tobias Hölle, Jan C Purrucker, Benedict Morath, Markus A Weigand, Felix C F Schmitt
Impaired consciousness is a frequent phenomenon after general anesthesia. In addition to the classical causes (e.g., overhang of sedatives), an impairment of consciousness can also be an adverse side effect of drugs. Many drugs used in anesthesia can trigger these symptoms. Alkaloids, such as atropine can trigger a central anticholinergic syndrome, opioids can promote the occurrence of serotonin syndrome and the administration of a neuroleptic can lead to neuroleptic malignant syndrome. These three syndromes are difficult to diagnose due to the individually very heterogeneous symptoms...
2023: Wiener Klinisches Magazin: Beilage Zur Wiener Klinischen Wochenschrift
https://read.qxmd.com/read/37232644/sleep-and-lifestyle-habits-of-medical-and-non-medical-students-during-the-covid-19-lockdown
#33
JOURNAL ARTICLE
Ivana Pavlinac Dodig, Linda Lusic Kalcina, Sijana Demirovic, Renata Pecotic, Maja Valic, Zoran Dogas
It has been shown that the measures of social distancing and lockdown might have had negative effects on the physical and mental health of the population. We aim to investigate the sleep and lifestyle habits as well as the mood of Croatian medical (MS) and non-medical students (NMS) during the COVID-19 lockdown. The cross-sectional study included 1163 students (21.6% male), whose lifestyle and sleep habits and mood before and during the lockdown were assessed with an online questionnaire. The shift towards later bedtimes was more pronounced among NMS (~65 min) compared to MS (~38 min), while the shift toward later wake-up times was similar in both MS (~111 min) and NMS (~112 min)...
May 13, 2023: Behavioral Sciences
https://read.qxmd.com/read/37016807/false-memories-formation-after-a-retention-period-spent-asleep-or-awake-in-individuals-with-insomnia-and-good-sleepers-a-polysomnographic-study
#34
JOURNAL ARTICLE
Serena Malloggi, Francesca Conte, Oreste De Rosa, Nicola Cellini, Gioele Gavazzi, Ilaria Di Iorio, Gianluca Ficca, Fiorenza Giganti
False memories are a possible by-product of sleep-related memory consolidation processes when delayed testing is performed after a retention interval spent asleep. To date, the effect of a retention period spent asleep or awake on false memories formation has been addressed only in healthy subjects, while neglecting sleep-disordered populations. In the present study, we investigated this effect in 17 insomniacs and 15 good sleepers through the Deese-Roediger-McDermott paradigm. In both groups, the encoding phase was followed by an 8-h retention period spent in polysomnography monitored sleep (S-condition) or wake (WK-condition)...
April 4, 2023: Journal of Sleep Research
https://read.qxmd.com/read/36963463/consensus-recommendations-on-sleeping-problems-in-phelan-mcdermid-syndrome
#35
JOURNAL ARTICLE
A San José Cáceres, A M Landlust, J M Carbin
Early onset sleep problems and disorders are very common in individuals with Phelan-McDermid Syndrome (PMS) with rates of up to 90%. These sleep problems and disorders cannot be taken lightly. Not only do they have a major impact on the health, behaviour, functioning and learning opportunities of affected individuals, they can also have detrimental effects on the well-being and resilience of parents and caregivers, ultimately affecting the physical health, mental health and well-being of the whole social system...
March 22, 2023: European Journal of Medical Genetics
https://read.qxmd.com/read/36916185/catatonia-associated-with-prolonged-stupor-after-general-anesthesia-in-a-patient-with-multiple-neuropsychiatric-disorders-a-case-report
#36
Sungwon Baek, Min Hee Heo, Kyung Woo Kim, Sang Il Lee, Kyung-Tae Kim, Jang Su Park, Won Joo Choe, Jun Hyun Kim, Ji Yeon Kim
BACKGROUND: Delayed emergence after general anesthesia may indicate a significant impact on the patient's condition. We present a case of a patient who experienced delayed recovery of consciousness, language, and motor response due to catatonia after more than eight hours of total elbow arthroplasty under general anesthesia. CASE: A 68-year-old woman with neuropsychiatric disorders and Parkinson's disease did not respond adequately during recovery after more than eight hours of general anesthesia...
March 14, 2023: Korean Journal of Anesthesiology
https://read.qxmd.com/read/36872647/incidence-of-acute-neurological-events-in-neonates-and-infants-undergoing-cardiac-surgery-using-a-high-hematocrit-high-flow-bypass-strategy
#37
JOURNAL ARTICLE
Abhishek Chakraborty, Karthik Ramakrishnan, Cihangir Buyukgoz, Sachin Tadphale, Jerry Allen, Mohammed Absi, Maria Briceno-Medina, Umar Boston, Christopher J Knott-Craig
Background: The incidence of new acute neurological injury occurring in neonates and infants during cardiac surgery utilizing cardiopulmonary bypass is reportedly 3% to 5%. In 2013, we adopted a high flow rate, and high hematocrit bypass strategy, and sought to assess the incidence of early neurological injuries associated with this strategy. Methods: Neonates and infants undergoing cardiopulmonary bypass between January 2013 and December 2019 (n  =  714) comprise the study. Adverse neurological events (ANEs) were defined as any abnormality of pupils, delayed awakening, seizures, focal neurological deficits, concerns prompting neurological consultation, or any abnormality on neurological imaging in the postoperative period...
May 2023: World Journal for Pediatric & Congenital Heart Surgery
https://read.qxmd.com/read/36868094/carwatch-a-smartphone-application-for-improving-the-accuracy-of-cortisol-awakening-response-sampling
#38
JOURNAL ARTICLE
Robert Richer, Luca Abel, Arne Küderle, Bjoern M Eskofier, Nicolas Rohleder
BACKGROUND: Many studies investigating the cortisol awakening response (CAR) suffer from low adherence to the study protocol as well as from the lack of precise and objective methods for assessing the awakening and saliva sampling times which leads to measurement bias on CAR quantification. METHODS: To address this issue, we have developed "CARWatch", a smartphone application that aims to enable low-cost and objective assessment of saliva sampling times as well as to concurrently increase protocol adherence...
May 2023: Psychoneuroendocrinology
https://read.qxmd.com/read/36858383/-acupuncture-for-delayed-sleep-wake-phase-disorder-a-randomized-controlled-trial
#39
RANDOMIZED CONTROLLED TRIAL
Xin-Tong Yu, Wen-Jia Yang, Na Zhao, Rui-Long Liang, Xu-Qiu Sun, Yue-Ping Bi, Yan-Yan Mou
OBJECTIVE: To observe the clinical effect of acupuncture for delayed sleep-wake phase disorder (DSWPD). METHODS: A total of 84 patients with DSWPD were randomized into an observation group (42 cases, 2 cases dropped off) and a control group (42 cases, 3 cases dropped off). On the basis of sleep hygiene education, acupuncture was applied at Shenmai (BL 62), Zhaohai (KI 6), Hegu (LI 4), Taichong (LR 3), Zusanli (ST 36) and Sanyinjiao (SP 6) in the observation group, while placebo acupuncture was applied at the same acupoints in the control group...
March 12, 2023: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://read.qxmd.com/read/36799968/-central-anticholinergic-neuroleptic-malignant-and-serotonin-syndromes-important-differential-diagnoses-in-postoperative-impairment-of-consciousness
#40
REVIEW
Tobias Hölle, Jan C Purrucker, Benedict Morath, Markus A Weigand, Felix C F Schmitt
Impaired consciousness is a frequent phenomenon after general anesthesia. In addition to the classical causes (e.g., overhang of sedatives), an impairment of consciousness can also be an adverse side effect of drugs. Many drugs used in anesthesia can trigger these symptoms. Alkaloids, such as atropine can trigger a central anticholinergic syndrome, opioids can promote the occurrence of serotonin syndrome and the administration of a neuroleptic can lead to neuroleptic malignant syndrome. These three syndromes are difficult to diagnose due to the individually very heterogeneous symptoms...
February 17, 2023: Anaesthesiologie
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