Samuel Rommelaere, Alexia Carboni, Juan F Bada Juarez, Jean-Philippe Boquete, Luciano A Abriata, Fernando Teixeira Pinto Meireles, Verena Rukes, Crystal Vincent, Shu Kondo, Marc S Dionne, Matteo Dal Peraro, Chan Cao, Bruno Lemaitre
7An efficient immune system must provide protection against a broad range of pathogens without causing excessive collateral tissue damage. While immune effectors have been well characterized, we know less about the resilience mechanisms protecting the host from its own immune response. Antimicrobial peptides (AMPs) are small, cationic peptides that contribute to innate defenses by targeting negatively charged membranes of microbes. While protective against pathogens, AMPs can be cytotoxic to host cells. Here, we reveal that a family of stress-induced proteins, the Turandots, protect the Drosophila respiratory system from AMPs, increasing resilience to stress...
March 5, 2024: Current Biology: CB