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cationic antimicrobial peptide

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https://www.readbyqxmd.com/read/28212487/interactions-between-membranes-and-metaphilic-polypeptide-architectures-with-diverse-sidechain-populations
#1
Michelle W Lee, Ming Han, Guilherme Volpe Bossa, Carly Snell, Ziyuan Song, Haoyu Tang, Lichen Yin, Jianjun Cheng, Sylvio May, Erik Luijten, Gerard C L Wong
At physiological conditions, most proteins or peptides can fold into relatively stable structures that present on their molecular surfaces specific chemical patterns partially smeared out by thermal fluctuations. These nanoscopically defined patterns of charge, hydrogen bonding, and/or hydrophobicity, along with their elasticity and shape stability (folded proteins have Young's moduli of ~1 × 10(8) Pa), largely determine and limit the interactions of these molecules, such as molecular recognition and allosteric regulation...
February 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/28203238/differential-ability-of-bovine-antimicrobial-cathelicidins-to-mediate-nucleic-acid-sensing-by-epithelial-cells
#2
Arnaud Baumann, Mirjam Susanna Kiener, Brendan Haigh, Vincent Perreten, Artur Summerfield
Cathelicidins encompass a family of cationic peptides characterized by antimicrobial activity and other functions, such as the ability to enhance the sensing of nucleic acids by the innate immune system. The present study aimed to investigate the ability of the bovine cathelicidins indolicidin, bactenecin (Bac)1, Bac5, bovine myeloid antimicrobial peptide (BMAP)-27, BMAP-28, and BMAP-34 to inhibit the growth of bacteria and to enhance the sensing of nucleic acid by the host's immune system. BMAP-27 was the most effective at killing Staphylococcus aureus, Streptococcus uberis, and Escherichia coli, and this was dependent on its amphipathic structure and cationic charge...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28203232/cationic-net-charge-and-counter-ion-type-as-antimicrobial-activity-determinant-factors-of-short-lipopeptides
#3
Katarzyna E Greber, Malgorzata Dawgul, Wojciech Kamysz, Wieslaw Sawicki
To get a better insight into the antimicrobial potency of short cationic lipopeptides, 35 new entities were synthesized using solid phase peptide strategy. All newly obtained lipopeptides were designed to be positively charged from +1 to +4. This was achieved by introducing basic amino acid - lysine - into the lipopeptide structure and had a hydrophobic fatty acid chain attached. Lipopeptides were subjected to microbiological tests using reference strains of Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Pseudomonas aeruginosa, Gram-positive bacteria: Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Enterococcus faecalis, and fungi: Candida albicans, Candida tropicalis, Aspergillus brasiliensis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28203100/from-amino-acids-polymers-antimicrobial-peptides-and-histones-to-their-possible-role-in-the-pathogenesis-of-septic-shock-a-historical-perspective
#4
Isaac Ginsburg, Peter Vernon van Heerden, Erez Koren
This paper describes the evolution of our understanding of the biological role played by synthetic and natural antimicrobial cationic peptides and by the highly basic nuclear histones as modulators of infection, postinfectious sequelae, trauma, and coagulation phenomena. The authors discuss the effects of the synthetic polymers of basic poly α amino acids, poly l-lysine, and poly l-arginine on blood coagulation, fibrinolysis, bacterial killing, and blood vessels; the properties of natural and synthetic antimicrobial cationic peptides as potential replacements or adjuncts to antibiotics; polycations as opsonizing agents promoting endocytosis/phagocytosis; polycations and muramidases as activators of autolytic wall enzymes in bacteria, causing bacteriolysis and tissue damage; and polycations and nuclear histones as potential virulence factors and as markers of sepsis, septic shock, disseminated intravasclar coagulopathy, acute lung injury, pancreatitis, trauma, and other additional clinical disorders...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28198085/the-alternative-sigma-factor-%C3%AF-b-plays-a-crucial-role-in-adaptive-strategies-of-clostridium-difficile-during-gut-infection
#5
Nicolas Kint, Claire Janoir, Marc Monot, Sandra Hoys, Olga Soutourina, Bruno Dupuy, Isabelle Martin-Verstraete
Clostridium difficile is a major cause of diarrhoea associated with antibiotherapy. Exposed to stresses in the gut, C. difficile can survive by inducing protection, detoxification, and repair systems. In several firmicutes, most of these systems are controlled by the general stress response involving σ(B) . In this work, we studied the role of σ(B) in the physiopathology of C. difficile. We showed that the survival of the sigB mutant during the stationary phase was reduced. Using a transcriptome analysis, we showed that σ(B) controls the expression of ∼25% of genes including genes involved in sporulation, metabolism, cell surface biogenesis, and the management of stresses...
February 15, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28195195/peptoids-successfully-inhibit-the-growth-of-gram-negative-e-coli-causing-substantial-membrane-damage
#6
Biljana Mojsoska, Gustavo Carretero, Sylvester Larsen, Ramona Valentina Mateiu, Håvard Jenssen
Peptoids are an alternative approach to antimicrobial peptides that offer higher stability towards enzymatic degradation. It is essential when developing new types of peptoids, that mimic the function of antimicrobial peptides, to understand their mechanism of action. Few studies on the specific mechanism of action of antimicrobial peptoids have been described in the literature, despite the plethora of studies on the mode of action of antimicrobial peptides. Here, we investigate the mechanism of action of two short cationic peptoids, rich in lysine and tryptophan side chain functionalities...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28193899/structure-of-a-lipid-a-phosphoethanolamine-transferase-suggests-how-conformational-changes-govern-substrate-binding
#7
Anandhi Anandan, Genevieve L Evans, Karmen Condic-Jurkic, Megan L O'Mara, Constance M John, Nancy J Phillips, Gary A Jarvis, Siobhan S Wills, Keith A Stubbs, Isabel Moraes, Charlene M Kahler, Alice Vrielink
Multidrug-resistant (MDR) gram-negative bacteria have increased the prevalence of fatal sepsis in modern times. Colistin is a cationic antimicrobial peptide (CAMP) antibiotic that permeabilizes the bacterial outer membrane (OM) and has been used to treat these infections. The OM outer leaflet is comprised of endotoxin containing lipid A, which can be modified to increase resistance to CAMPs and prevent clearance by the innate immune response. One type of lipid A modification involves the addition of phosphoethanolamine to the 1 and 4' headgroup positions by phosphoethanolamine transferases...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28185358/effects-of-arginine-and-leucine-substitutions-on-anti-endotoxic-activities-and-mechanisms-of-action-of-cationic-and-amphipathic-antimicrobial-octadecapeptide-from-rice-%C3%AE-amylase
#8
Masayuki Taniguchi, Akihito Ochiai, Ryu Toyoda, Teppei Sato, Eiichi Saitoh, Tetsuo Kato, Takaaki Tanaka
Previously, we showed that the antimicrobial cationic and amphipathic octadecapeptide AmyI-1-18 from rice α-amylase (AmyI-1) inhibited the endotoxic activity of lipopolysaccharide (LPS) from Escherichia coli. In addition, we demonstrated that several AmyI-1-18 analogs containing arginine or leucine substitutions, which were designed on the basis of the helical wheel projection of AmyI-1-18, exhibited higher antimicrobial activity against human pathogenic microorganisms than AmyI-1-18. In the present study, anti-inflammatory (anti-endotoxic) activities of five AmyI-1-18 analogs containing arginine or leucine substitutions were investigated...
February 10, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28183247/streptomyces-as-overexpression-system-for-heterologous-production-of-an-antimicrobial-peptide
#9
Marisol Roldán-Tapia, Jozef Anné, Ana Gisela Reyes, Ulises Carrasco, Cesar Millán-Pacheco, Javier Barrios-González, Armando Mejía
Defense mechanisms of plants against phytopathogens include cationic antimicrobial peptides (CAPs). The broad-spectrum activity of these peptides has been evaluated previously against different phytopathogens. Their lack of toxicity for plants and animals is a promising feature for pest control. Although, some attempts have been made previously in order to increase their heterologous expressions, the employed strategies have so far proven to be ineffective. Low production yield and elevated costs are the obstacles to overcome...
February 8, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28178190/high-specific-selectivity-and-membrane-active-mechanism-of-synthetic-cationic-hybrid-antimicrobial-peptides-based-on-the-peptide-fv7
#10
Tingting Tan, Di Wu, Weizhong Li, Xin Zheng, Weifen Li, Anshan Shan
Hybrid peptides integrating different functional domains of peptides have many advantages, such as remarkable antimicrobial activity, lower hemolysis and ideal cell selectivity, compared with natural antimicrobial peptides. FV7 (FRIRVRV-NH₂), a consensus amphiphilic sequence was identified as being analogous to host defense peptides. In this study, we designed a series of hybrid peptides FV7-LL-37 (17-29) (FV-LL), FV7-magainin 2 (9-21) (FV-MA) and FV7-cecropin A (1-8) (FV-CE) by combining the FV7 sequence with the small functional sequences LL-37 (17-29) (LL), magainin 2 (9-21) (MA) and cecropin A (1-8) (CE) which all come from well-described natural peptides...
February 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28167938/comparative-analysis-of-the-bacterial-membrane-disruption-effect-of-two-natural-plant-antimicrobial-peptides
#11
Attila Farkas, Gergely Maróti, Attila Kereszt, Éva Kondorosi
In the Medicago truncatula genome about 700 genes code for nodule-specific cysteine-rich (NCR) small peptides that are expressed in the symbiotic organ, the root nodule, where they control terminal differentiation of the endosymbiotic rhizobium bacteria to nitrogen-fixing bacteroids. Cationic NCR peptides were predicted to have antimicrobial activities. Here antibacterial activities of NCR247, NCR335, polymyxin B (PMB), and streptomycin were investigated and compared on two foodborne pathogens Salmonella enterica and Listeria monocytogenes as representatives of Gram-negative and Gram-positive bacteria...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28165293/anticancer-activities-of-bovine-and-human-lactoferricin-derived-peptides
#12
Mauricio Arias, Ashley L Hilchie, Evan F Haney, Jan G M Bolscher, M Eric Hyndman, Robert E W Hancock, Hans J Vogel
Lactoferrin (LF) is a mammalian host defense glycoprotein with diverse biological activities. Peptides derived from the cationic region of LF possess cytotoxic activity against cancer cells in vitro and in vivo. Bovine lactoferricin (LFcinB), a peptide derived from bovine LF (bLF), exhibits broad-spectrum anticancer activity, while a similar peptide derived from human LF (hLF) is not as active. In this work, several peptides derived from the N-terminal regions of bLF and hLF were studied for their anticancer activities against leukemia and breast-cancer cells, as well as normal peripheral blood mononuclear cells...
February 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28164707/discovery-of-novel-antimicrobial-peptides-from-varanus-komodoensis-komodo-dragon-by-large-scale-analyses-and-de-novo-assisted-sequencing-using-electron-transfer-dissociation-mass-spectrometry
#13
Barney M Bishop, Melanie L Juba, Paul S Russo, Megan Devine, Stephanie M Barksdale, Shaylyn Scott, Robert Settlage, Pawel Michalak, Kajal Gupta, Kent Vliet, Joel M Schnur, Monique L van Hoek
Komodo dragons are the largest living lizards and are the apex predators in their environs. They endure numerous strains of pathogenic bacteria in their saliva and recover from wounds inflicted by other dragons, reflecting the inherent robustness of their innate immune defense. We have employed a custom bioprospecting approach combining partial de novo peptide sequencing with transcriptome assembly to identify cationic antimicrobial peptides from Komodo dragon plasma. Through these analyses, we identified 48 novel potential cationic antimicrobial peptides...
February 6, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28159722/cell-penetrating-and-cargo-delivery-ability-of-a-spider-toxin-derived-peptide-in-mammalian-cells
#14
Nisha Ponnappan, Archana Chugh
Cell-penetrating peptides are short cationic peptides with inherent ability to cross the plasma membrane barrier as well as intracellularly deliver cargo molecules conjugated to them. Venoms from snakes, scorpions and spiders are rich in membrane-active peptides. Crotamine from snake venom as well as maurocalcine and imperatoxin isolated from scorpion venoms have been reported to possess cell-penetrating property in mammalian cells. Latarcins, a group of spider venom toxins, has also been reported to possess antimicrobial property...
January 31, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28159460/antimicrobial-effects-of-novel-peptides-cot2-and-sot2-derived-from-crocodylus-siamensis-and-pelodiscus-sinensis-ovotransferrins
#15
Bung-On Prajanban, Nisachon Jangpromma, Tomohiro Araki, Sompong Klaynongsruang
In light of the increasing threat of bacterial drug resistance to human health on a global scale, research and development of antimicrobial peptides as a novel class of potent antibiotics has gained considerable attention. The present study focuses on the structural evaluation and membrane interaction of two new cationic antimicrobial peptides, cOT2 and sOT2, derived from Siamese crocodile (Crocodylus siamensis) and Chinese softshell turtle (Pelodiscus sinensis) ovotransferrins. Here, cOT1 (+3) and sOT1 (+3) were derived from reptile ovotransferrins by chromatographic purification and characterized by mass spectrometry and N-terminal sequencing analysis...
February 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28140564/mussel-inspired-multifunctional-hydrogel-coating-for-prevention-of-infections-and-enhanced-osteogenesis
#16
Hao Cheng, Kan Yue, Mehdi Kazemzadeh-Narbat, Yanhui Liu, Akbar Khalilpour, Bingyun Li, Yu Shrike Zhang, Nasim Annabi, Ali Khademhosseini
Prevention of post-surgery infection and promotion of bio-integration are the key factors to achieve long-term success in orthopaedic implants. Localized delivery of antibiotics and bioactive molecules by the implant surface serves as a promising approach towards these goals. However, previously reported methods for surface functionalization of the titanium (Ti) alloy implants to load bioactive ingredients suffer from time-consuming complex processes and lack of long-term stability. Here, we present the design and characterization of an adhesive, osteoconductive, and antimicrobial hydrogel coating for Ti implants...
January 31, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28131941/rationally-designed-dual-functional-block-copolymers-for-bottlebrush-like-coatings-in-vitro-and-in-vivo-antimicrobial-antibiofilm-and-antifouling-properties
#17
Qiang Gao, Meng Yu, Yajuan Su, Meihua Xie, Xin Zhao, Peng Li, Peter X Ma
: Numerous antimicrobial coatings have been developed for biomedical devices/implants, but few can simultaneously fulfill the requirements for antimicrobial and antifouling ability and biocompatibility. In this study, to develop an antimicrobial and antibiofilm surface coating, diblock amphiphilic molecules with antimicrobial and antifouling segments in a single chain were rationally designed and synthesized. Cationic antimicrobial polypeptides (AMP) were first synthesized by N-carboxyanhydride ring-opening polymerization (NCA-ROP)...
January 25, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28131846/novel-human-bioactive-peptides-identified-in-apolipoprotein-b-evaluation-of-their-therapeutic-potential
#18
Rosa Gaglione, Eliana Dell'Olmo, Andrea Bosso, Marco Chino, Katia Pane, Flora Ascione, Francesco Itri, Sergio Caserta, Angela Amoresano, Angelina Lombardi, Henk P Haagsman, Renata Piccoli, Elio Pizzo, Edwin J A Veldhuizen, Eugenio Notomista, Angela Arciello
Host defence peptides (HDPs) are short, cationic amphipathic peptides that play a key role in the response to infection and inflammation in all complex life forms. It is increasingly emerging that HDPs generally have a modest direct activity against a broad range of microorganisms, and that their anti-infective properties are mainly due to their ability to modulate the immune response. Here, we report the recombinant production and characterization of two novel HDPs identified in human Apolipoprotein B (residues 887-922) by using a bioinformatics method recently developed by our group...
January 25, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28129513/a-comparative-cross-species-investigation-of-the-properties-and-roles-of-transferrin-and-lactoferrin-binding-protein-b-from-pathogenic-bacteria
#19
N Ostan, A Morgenthau, R H Yu, S D Gray-Owen, A B Schryvers
Pathogenic bacteria from the families Neisseriaeceae and Moraxellaceae acquire iron from their host using surface receptors that have the ability to hijack iron from the iron-sequestering host proteins transferrin (Tf) and lactoferrin (Lf). The process of acquiring iron from Tf has been well-characterized, including the role of the surface lipoprotein transferrin-binding protein B (TbpB). In contrast, the only well-defined role for the homologue, LbpB, is in its protection against cationic antimicrobial peptides, which is mediated by regions present in some LbpBs that are highly enriched in glutamic or aspartic acid...
February 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28122182/symmetrically-substituted-xanthone-amphiphiles-combat-gram-positive-bacterial-resistance-with-enhanced-membrane-selectivity
#20
Shuimu Lin, Jun-Jie Koh, Thet Tun Aung, Fanghui Lim, Jianguo Li, Hanxun Zou, Lin Wang, Rajamani Lakshminarayanan, Chandra S Verma, Yingjun Wang, Donald T H Tan, Derong Cao, Roger W Beuerman, Li Ren, Shouping Liu
This study is the first report of the design of a new series of symmetric xanthone derivatives that mimic antimicrobial peptides (AMPs) using a total synthesis approach. This novel design is advantageous because of its low cost, synthetic simplicity and versatility, and easy tuning of amphiphilicity by controlling the incorporated cationic and hydrophobic moieties. Two water-soluble optimized compounds, 6 and 18, showed potent activities against Gram-positive bacteria, including MRSA and VRE (MICs = 0.78-6...
January 25, 2017: Journal of Medicinal Chemistry
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