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https://www.readbyqxmd.com/read/29217114/identification-of-bacterial-uropathogens-by-preparative-isoelectric-focusing-and-maldi-tof-mass-spectrometry
#1
Jiří Šalplachta, Marie Horká, Filip Růžička, Karel Šlais
This study describes a new method for simultaneous identification of uropathogens in the case of polybacterial urinary tract infections. The method utilizes recently developed preparative isoelectric focusing (IEF) in cellulose-based separation medium with a subsequent analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Preparative IEF was successfully used for both purification and separation of bacteria, Escherichia coli (pI 4.6) and Staphylococcus aureus (pI 3...
December 2, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29028005/microbiome-and-infectivity-studies-reveal-complex-polyspecies-tree-disease-in-acute-oak-decline
#2
Sandra Denman, James Doonan, Emma Ransom-Jones, Martin Broberg, Sarah Plummer, Susan Kirk, Kelly Scarlett, Andrew R Griffiths, Maciej Kaczmarek, Jack Forster, Andrew Peace, Peter N Golyshin, Francis Hassard, Nathan Brown, John G Kenny, James E McDonald
Decline-diseases are complex and becoming increasingly problematic to tree health globally. Acute Oak Decline (AOD) is characterized by necrotic stem lesions and galleries of the bark-boring beetle, Agrilus biguttatus, and represents a serious threat to oak. Although multiple novel bacterial species and Agrilus galleries are associated with AOD lesions, the causative agent(s) are unknown. The AOD pathosystem therefore provides an ideal model for a systems-based research approach to address our hypothesis that AOD lesions are caused by a polymicrobial complex...
October 13, 2017: ISME Journal
https://www.readbyqxmd.com/read/28799230/human-dendritic-cells-activated-with-mv130-induce-th1-th17-and-il-10-responses-via-ripk2-and-myd88-signalling-pathways
#3
Cristina Cirauqui, Cristina Benito-Villalvilla, Silvia Sánchez-Ramón, Sofía Sirvent, Carmen M Diez-Rivero, Laura Conejero, Paola Brandi, Lourdes Hernández-Cillero, Juliana Lucía Ochoa, Beatriz Pérez-Villamil, David Sancho, José Luis Subiza, Oscar Palomares
Recurrent respiratory tract infections (RRTIs) are the first leading cause of community- and nosocomial-acquired infections. Antibiotics remain the mainstay of treatment, enhancing the potential to develop antibiotic resistances. Therefore, the development of new alternative approaches to prevent and treat RRTIs is highly demanded. Daily sublingual administration of the whole heat-inactivated polybacterial preparation (PBP) MV130 significantly reduced the rate of respiratory infections in RRTIs patients, however, the immunological mechanisms of action remain unknown...
August 11, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28700747/the-association-between-ethnicity-and-vaginal-microbiota-composition-in-amsterdam-the-netherlands
#4
Hanneke Borgdorff, Charlotte van der Veer, Robin van Houdt, Catharina J Alberts, Henry J de Vries, Sylvia M Bruisten, Marieke B Snijder, Maria Prins, Suzanne E Geerlings, Maarten F Schim van der Loeff, Janneke H H M van de Wijgert
OBJECTIVE: To evaluate whether ethnicity is independently associated with vaginal microbiota (VMB) composition in women living in Amsterdam, the Netherlands, as has been shown for American women. METHODS: Women (18-34 years, non-pregnant, N = 610) representing the six largest ethnic groups (Dutch, African Surinamese, South-Asian Surinamese, Turkish, Moroccan, and Ghanaian) were sampled from the population-based HELIUS study. Sampling was performed irrespective of health status or healthcare seeking behavior...
2017: PloS One
https://www.readbyqxmd.com/read/28602746/role-of-oral-and-gut-microbiome-in-nitric-oxide-mediated-colon-motility
#5
REVIEW
Miriam Y Walker, Siddharth Pratap, Janet H Southerland, Cherae M Farmer-Dixon, Kesavalu Lakshmyya, Pandu R Gangula
Periodontal disease (PD), a severe form of gum disease, is among the most prevalent chronic infection in humans and is associated with complex microbial synergistic dysbiosis in the subgingival cavity. The immune system of the body interacts with the microbes as the plaque extends and propagates below the gingival sulcus. Once bacteria reach the gingival sulcus, it can enter the blood stream and affect various areas of the human body. The polymicrobial nature of periodontal disease, if left untreated, promotes chronic inflammation, not only within the oral cavity, but also throughout the human body...
June 7, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28582985/septic-pericarditis-and-pneumopericardium-in-a-dog-with-an-oesophageal-foreign-body
#6
Willem J Botha, Varaidzo Mukorera, Robert M Kirberger
A 5-year-old, intact, male Yorkshire Terrier presented with a 6-day history of lethargy and anorexia. Clinical examination revealed dental plaque accumulation, abdominal effort during respiration and muffled heart sounds. Thoracic radiographs revealed an enlarged globoid cardiac silhouette and mild pneumopericardium, transthoracic ultrasonography revealed a pericardial effusion after which pericardiocentesis, cytology and culture diagnosed septic pericarditis. Three multidrug-resistant bacteria were isolated, two of which have been implicated in gas-producing infections before...
May 29, 2017: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/28579041/clinical-perspectives-of-digital-dermatitis-in-dairy-and-beef-cattle
#7
REVIEW
Paul J Plummer, Adam Krull
Digital dermatitis is a polybacterial disease process of dairy and beef cattle. Lesions are most commonly identified on the plantar aspect of the interdigital cleft of the hind limbs. Treponema spp are routinely present in large numbers of active lesions. Lesions are painful to the touch and can result in clinical lameness. The infectious nature generally results in endemic infection of cattle herds and management requires a comprehensive and integrated multipronged approach. This article provides current perspectives regarding management and treatment of digital dermatitis on dairy and beef cattle operations and provides a review for clinicians dealing with a clinical outbreak...
July 2017: Veterinary Clinics of North America. Food Animal Practice
https://www.readbyqxmd.com/read/28458871/candida-parapsilosis-associated-with-cervical-necrotizing-fasciitis-and-descending-mediastinitis
#8
Chung-Ching Lee, Wing-Kei Choi, Jimmy Yu-Wai Chan
BACKGROUND: This report presents an immunocompetent lady suffering from Candida parapsilosis associated with polybacterial cervical necrotizing fasciitis and descending mediastinitis. A literature review and management of invasive candidiasis is discussed. METHODS: A 57-year-old healthy lady presented with cervical necrotizing fasciitis and descending mediastinitis. She was promptly managed with emergency debridement. Both blood and tissue culture yielded multiple microorganisms including C...
April 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28257809/the-global-health-impact-of-vaginal-dysbiosis
#9
Janneke H H M van de Wijgert, Vicky Jespers
The most common dysbiosis of the vaginal microbiome (defined here as a vaginal microbiome not dominated by lactobacilli) is bacterial vaginosis, an anaerobic polybacterial dysbiosis. Other dysbiotic states of importance to global health are vaginal microbiota with a high abundance of streptococci, staphylococci or Enterobacteriaceae, vaginal candidiasis and trichomoniasis. Knowledge about the different types of dysbiosis and their relationship to urogenital and reproductive disease burden has increased in recent years by applying non-culture-based techniques, but is far from complete...
March 1, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28059171/comparison-of-sputum-microbiome-of-legionellosis-associated-patients-and-other-pneumonia-patients-indications-for-polybacterial-infections
#10
Hila Mizrahi, Avi Peretz, René Lesnik, Yana Aizenberg-Gershtein, Sara Rodríguez-Martínez, Yehonatan Sharaby, Nina Pastukh, Ingrid Brettar, Manfred G Höfle, Malka Halpern
Bacteria of the genus Legionella cause water-based infections resulting in severe pneumonia. Here we analyze and compare the bacterial microbiome of sputum samples from pneumonia patients in relation to the presence and abundance of the genus Legionella. The prevalence of Legionella species was determined by culture, PCR, and Next Generation Sequencing (NGS). Nine sputum samples out of the 133 analyzed were PCR-positive using Legionella genus-specific primers. Only one sample was positive by culture. Illumina MiSeq 16S rRNA gene sequencing analyses of Legionella-positive and Legionella-negative sputum samples, confirmed that indeed, Legionella was present in the PCR-positive sputum samples...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27870156/combinations-and-loads-of-bacteria-affect-the-cytokine-production-by-fetal-membranes-an-in-vitro-study
#11
Nathalia Mayumi Noda-Nicolau, Jossimara Polettini, Morgan R Peltier, Márcia Guimarães da Silva, Ramkumar Menon
PROBLEM: The polybacterial invasion and inflammation of the amniotic cavity is a common scenario in PTB, and then, we analyzed the cytokine production by human fetal membranes to better understand the host response to polybacterial infections. METHOD OF STUDY: Fetal membranes were treated by heat-inactivated genital mycoplasmas and Gardnerella vaginalis at 10(3) or 10(6) colony/color-forming units/mL alone or in combination. Cytokines/receptors were measured in the medium by immunoassays...
December 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27580179/anti-inflammatory-elafin-in-human-fetal-membranes
#12
Cecilia Stalberg, Nathalia Noda, Jossimara Polettini, Bo Jacobsson, Ramkumar Menon
OBJECTIVE: Elafin is a low molecular weight protein with antileukoproteinase, anti-inflammatory, antibacterial and immunomodulating properties. The profile of Elafin in fetal membranes is not well characterized. This study determined the changes in Elafin expression and concentration in human fetal membrane from patients with preterm prelabor rupture of membranes (PPROM) and in vitro in response to intra-amniotic polymicrobial pathogens. METHOD: Elafin messenger RNA (mRNA) expressions were studied in fetal membranes from PPROM, normal term as well as in normal term not in labor membranes in an organ explant system treated (24 h) with lipopolysaccharide (LPS), using quantitative reverse transcription-polymerase chain reaction (RT-PCR)...
February 1, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27573928/new-biological-insights-in-the-immunomodulatory-effects-of-mucosal-polybacterial-vaccines-in-clinical-practice
#13
Marta Tejera-Alhambra, Oscar Palomares, Rebeca Perez de Diego, Ignacio Diaz-Lezcano, Silvia Sanchez-Ramon
A main focus in healthcare is the active search for alternative strategies to antibiotics, both for prophylactic and therapeutical interventions, due to the accelerated and widespread increase in antibiotic resistance. This problem is more marked for patients with recurrent infections, in which the risk for antibiotic resistance and adverse effects is higher and can be life-threatening. Although antibiotics remain the mainstay of treatment for infectious diseases, prophylactic vaccines via the mucosal route in defined populations of patients with recurrent infections has gained use in recent years...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27508002/pattern-and-predictors-of-mortality-in-necrotizing-fasciitis-patients-in-a-single-tertiary-hospital
#14
Gaby Jabbour, Ayman El-Menyar, Ruben Peralta, Nissar Shaikh, Husham Abdelrahman, Insolvisagan Natesa Mudali, Mohamed Ellabib, Hassan Al-Thani
BACKGROUND: Necrotizing fasciitis (NF) is a fatal aggressive infectious disease. We aimed to assess the major contributing factors of mortality in NF patients. METHODS: A retrospective study was conducted at a single surgical intensive care unit between 2000 and 2013. Patients were categorized into 2 groups based on their in-hospital outcome (survivors versus non-survivors). RESULTS: During a14-year period, 331 NF patients were admitted with a mean age of 50...
2016: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/27405639/periodontal-bacterial-colonization-in-synovial-tissues-exacerbates-collagen-induced-arthritis-in-b10-riii-mice
#15
Sasanka Chukkapalli, Mercedes Rivera-Kweh, Prashasnika Gehlot, Irina Velsko, Indraneel Bhattacharyya, S John Calise, Minoru Satoh, Edward K L Chan, Joseph Holoshitz, Lakshmyya Kesavalu
BACKGROUND: It has been previously hypothesized that oral microbes may be an etiological link between rheumatoid arthritis (RA) and periodontal disease. However, the mechanistic basis of this association is incompletely understood. Here, we investigated the role of periodontal bacteria in induction of joint inflammation in collagen-induced arthritis (CIA) in B10.RIII mice. METHODS: CIA-prone B10.RIII mice were infected orally with a polybacterial mixture of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia for 24 weeks before induction of CIA...
July 12, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27224005/global-tlr2-and-4-deficiency-in-mice-impacts-bone-resorption-inflammatory-markers-and-atherosclerosis-to-polymicrobial-infection
#16
S S Chukkapalli, I M Velsko, M F Rivera-Kweh, H Larjava, A R Lucas, L Kesavalu
Toll-like-receptors (TLRs) play a significant role in the generation of a specific innate immune response against invading pathogens. TLR2 and TLR4 signaling contributes to infection-induced inflammation in periodontal disease (PD) and atherosclerosis. Observational studies point towards a relationship between PD and atherosclerosis, but the role of TLR2 and TLR4 in the recognition of multiple oral pathogens and their modulation of host response leading to atherosclerosis are not clear. We evaluated the role of TLR2 and TLR4 signaling in the induction of both PD and atherosclerosis in TLR2(-/-) and TLR4(-/-) mice to polymicrobial infection with periodontal pathogens Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Fusobacterium nucleatum...
June 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/26746575/antimicrobial-cathelicidin-peptide-ll-37-inhibits-the-pyroptosis-of-macrophages-and-improves-the-survival-of-polybacterial-septic-mice
#17
Zhongshuang Hu, Taisuke Murakami, Kaori Suzuki, Hiroshi Tamura, Johannes Reich, Kyoko Kuwahara-Arai, Toshiaki Iba, Isao Nagaoka
LL-37 is the only known member of the cathelicidin family of antimicrobial peptides in humans. In addition to its broad spectrum of antimicrobial activities, LL-37 can modulate various inflammatory reactions. We previously revealed that LL-37 suppresses the LPS/ATP-induced pyroptosis of macrophages in vitro by both neutralizing the action of LPS and inhibiting the response of P2X7 (a nucleotide receptor) to ATP. Thus, in this study, we further evaluated the effect of LL-37 on pyroptosis in vivo using a cecal ligation and puncture (CLP) sepsis model...
May 2016: International Immunology
https://www.readbyqxmd.com/read/26688539/polybacterial-aetiology-and-outcomes-in-patients-with-community-acquired-pneumonia
#18
S Kumagai, T Ishida, H Tachibana, A Ito, Y Ito, T Hashimoto
SETTING: Community-acquired pneumonia (CAP) is a common cause of morbidity and mortality worldwide. While interactions among bacterial pathogens in the respiratory tract have been studied, the impact of polybacterial aetiology on mortality has not been fully elucidated. OBJECTIVE: To investigate the impact of polybacterial aetiology on mortality, prevalence, microbial patterns and clinical characteristics among CAP patients. DESIGN: Retrospective data analysis...
January 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/26619277/polymicrobial-oral-infection-with-four-periodontal-bacteria-orchestrates-a-distinct-inflammatory-response-and-atherosclerosis-in-apoe-null-mice
#19
Sasanka S Chukkapalli, Irina M Velsko, Mercedes F Rivera-Kweh, Donghang Zheng, Alexandra R Lucas, Lakshmyya Kesavalu
Periodontal disease (PD) develops from a synergy of complex subgingival oral microbiome, and is linked to systemic inflammatory atherosclerotic vascular disease (ASVD). To investigate how a polybacterial microbiome infection influences atherosclerotic plaque progression, we infected the oral cavity of ApoE null mice with a polybacterial consortium of 4 well-characterized periodontal pathogens, Porphyromonas gingivalis, Treponema denticola, Tannerealla forsythia and Fusobacterium nucleatum, that have been identified in human atherosclerotic plaque by DNA screening...
2015: PloS One
https://www.readbyqxmd.com/read/26569318/digital-dermatitis-in-cattle-current-bacterial-and-immunological-findings
#20
REVIEW
Jennifer H Wilson-Welder, David P Alt, Jarlath E Nally
Globally; digital dermatitis is a leading form of lameness observed in production dairy cattle. While the precise etiology remains to be determined; the disease is clearly associated with infection by numerous species of treponemes; in addition to other anaerobic bacteria. The goal of this review article is to provide an overview of the current literature; focusing on discussion of the polybacterial nature of the digital dermatitis disease complex and host immune response. Several phylotypes of treponemes have been identified; some of which correlate with location in the lesion and some with stages of lesion development...
2015: Animals: An Open Access Journal From MDPI
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