keyword
https://read.qxmd.com/read/38000940/influence-of-angiotensin-receptor-and-converting-enzyme-blockers-therapy-in-the-respiratory-outcome-of-covid-19-hospitalized-patients
#1
JOURNAL ARTICLE
Felipe B Lima, Francisco Wilker Mustafa Gomes Muniz, Gdayllon C Meneses, Karine C Bezerra, Carolyne N Moreira, André P Aguiar, José Carlos R Nascimento, Tainá Veras de S Freitas, Pedro Felipe C de Bruin, Eanes Delgado B Pereira, Elizabeth de F Daher, Reinaldo B Oriá
OBJECTIVES: COVID-19, caused by SARS-CoV-2, has spread around the world since 2019. In severe cases, COVID-19 can lead to hospitalization and death. Systemic arterial hypertension and other comorbidities are associated with serious COVID-19 infection. Literature is unclear whether antihypertensive therapy with angiotensin receptor blockers (ARBs) and angiotensin converting enzyme (ACE) inhibitors affect COVID-19 outcomes. We aim to assess whether ACEI/ARB therapy is a risk factor for worse respiratory outcomes related to COVID-19 in hospitalized patients...
November 23, 2023: Medicina Clínica
https://read.qxmd.com/read/37871566/-not-available
#2
JOURNAL ARTICLE
Edna Catering Rodríguez, Sandra Yamile Saavedra, Lucy Angeline Montaño, Diana Patricia Sossa, Francia Patricia Correa, Jireh Alejandra Vaca, Carolina Duarte
Introducción. Salmonella spp. es un agente patógeno zoonótico transmitido al humano por el agua o los alimentos contaminados. La presencia de β-lactamasas de espectro extendido es un creciente problema para la salud pública debido a que estas enzimas confieren resistencia contra las cefalosporinas de tercera y cuarta generación. Objetivo. Caracterizar las β-lactamasas de espectro extendido en aislamientos de Salmonella spp. recibidos por el programa de vigilancia de enfermedad diarreica aguda o enfermedad transmitida por alimentos del Grupo de Microbiología del Instituto Nacional de Salud...
September 30, 2023: Biomédica: Revista del Instituto Nacional de Salud
https://read.qxmd.com/read/37721915/-tipificaci%C3%A3-n-bioqu%C3%A3-mica-y-evaluaci%C3%A3-n-de-la-patogenicidad-de-aislamientos-vulvovaginales-del-complejo-candida-albicans
#3
JOURNAL ARTICLE
Soraya Morales-López, Keiner Ustate, Zulay Pedrozo, Yulibeth Torres
UNLABELLED: Introducción. Candida albicans, C. dubliniensis y C. africana forman el complejo Candida albicans. OBJETIVO: Identificar las características fenotípicas y patogénicas de aislamientos del complejo C. albicans conservados en una colección. Materiales y métodos. Se evaluaron 300 aislamientos identificados presuntivamente como del complejo C. albicans, utilizando CHROMagarTM Candida. Se determinó la producción del tubo germinal mediante tres métodos, se evaluó la producción de clamidosporas, se caracterizaron las colonias en agares artesanales (Rosmarinus officinalis y Nicotiana tabacum) y se utilizó MALDI-TOF como prueba de referencia para la identificación...
August 31, 2023: Biomédica: Revista del Instituto Nacional de Salud
https://read.qxmd.com/read/37678466/late-onset-postoperative-angioedema-triggered-by-angiotensin-converting-enzyme-inhibitor-an-emergent-airway-forethought
#4
J P Vinhal, L Carvalho, C Campos Costa, E Cernadas
Angioedema is a potentially life-threatening condition due to the risk of airway compromise leading to deterioration of respiratory function, hypoxia, and ultimately, cardiopulmonary arrest. It can be either unprovoked or triggered by pharmaceutical agents, emotional or physiologic factors, upper airway trauma, or surgical stress. A 46-year-old man previously prescribed perindopril developed angioedema of the tongue 4 h after being discharged from the Post Anesthesia Care Unit (PACU). A multidisciplinary team was called and they outlined an airway management strategy to use in the event of worsening...
September 5, 2023: Revista española de anestesiología y reanimación
https://read.qxmd.com/read/36542584/-creatine-phosphokinase-enzyme-elevation-in-two-third-level-hospitals-of-c%C3%A3-rdoba
#5
JOURNAL ARTICLE
Emanuel José Saad, Andrés Rodríguez Ruiz, Augusto Douthat Y Barrionuevo, Martín Milanesio, Janet Flores Balverdi, Nadia Claudine Riscanevo, Gabriela Estefanía Peñaranda, Elisa Beatriz Novatti, Verónica Saurit, Ana Cecilia Alvarez, Diego Federico Baenas
INTRODUCTION: HyperCKemia is defined as the elevation of creatine phosphokinase (CK) levels greater than 1.5 times the upper limit (CK>285 U/L), being produced by multiple causes, which vary according different populations. The main objective of the study was to know the frequency of hyperCKemia in two hospitals in Córdoba and its main causes. METHODS: Retrospective analytical study in two hospitals in Córdoba, Argentina, where all patients over 18 years of age who presented CK values ​​greater than 285 U/L on at least 2 occasions in a period between 1 and 4 weeks were identified, between the years 2015 and 2017...
December 21, 2022: Revista de la Facultad de Ciencias Médicas
https://read.qxmd.com/read/36322548/controversies-in-neuroimmunology-multiple-sclerosis-vaccination-sars-cov-2-and-other-dilemas
#6
JOURNAL ARTICLE
Saúl Reyes-Niño, Jaime Eduardo Rodríguez-Orozco, Habib Georges Moutran-Barroso, Hellen Kreinter-Rosembaun, Mariana Gaviria-Carrillo, Vanessa Salej-Durán, Julián Mancera-Charry, Ana Claudia Villegas, David Cuellar-Giraldo, Juan Sebastián Torres-Sandoval, Ángela Gómez-Mazuera, Aristides Duque-Samper, Jaime Toro-Gómez
Neuroimmunology is a discipline that increasingly broadens its horizons in the understanding of neurological diseases. At the same time, and in front of the pathophysiological links of neurological diseases and immunology, specific diagnostic and therapeutic approaches have been proposed. Despite the important advances in this discipline, there are multiple dilemmas that concern and filter into clinical practice. This article presents 15 controversies and a discussion about them, which are built with the most up-to-date evidence available...
October 31, 2022: Biomédica: Revista del Instituto Nacional de Salud
https://read.qxmd.com/read/35867915/disseminated-cryptococcosis-by-biological-therapy-we-must-manage-the-risk
#7
JOURNAL ARTICLE
Efraín Guillermo Sánchez, David Acosta, Juan Álvarez, Gabriela Sánchez, Julio García-Casallas
Introduction: Multiple adverse effects have been described for the biological therapy in autoimmune diseases including many secondary to immunosuppression producing bacterial, fungal, or viral infections. Clinical case: We present the case of a 64-year-old female patient with proven disseminated cryptococcosis secondary to the use of tofacitinib. Other possible causes of immunosuppression such as the human immunodeficiency virus (HIV) were ruled out. The patient had been in treatment for rheumatoid arthritis diagnosed three years before...
June 1, 2022: Biomédica: Revista del Instituto Nacional de Salud
https://read.qxmd.com/read/35817546/regulation-of-the-cellular-redox-state-and-the-expression-of-dna-methyltransferase-1-in-peripheral-blood-mononuclear-cells-from-patients-with-graves-disease
#8
JOURNAL ARTICLE
Melina Saban, Melisa Costilla, Alicia Juana Klecha, Mariana Di Cugno, Marina Inés Curria, Graciela Cremaschi, María Laura Barreiro Arcos
BACKGROUND: Graves' disease is an autoimmune disorder characterised by excessive production of thyroid hormones, which induces increased cellular metabolism in most tissues and increased production of reactive oxygen species (ROS). The aim of this work was to analyse the effect of ROS on cell viability and the expression of catalase (CAT), glutathione peroxidase-1 (GPx-1), superoxide dismutase (SOD-1) and DNA methyltransferase-1 (DNMT-1) in peripheral blood mononuclear cells (PBMC) from patients with newly diagnosed Graves' disease or treated with methimazole...
June 2022: Endocrinología, diabetes y nutrición
https://read.qxmd.com/read/35101366/long-term-exposure-to-cimetidine-induced-gonado-toxicity-in-male-rats-modulating-role-of-ocimum-gratissimum
#9
JOURNAL ARTICLE
Sunday Aderemi Adelakun, Babatunde Ogunlade, Olalekan Wasiu Akintunde, Victoria Ojima Omilachi
BACKGROUND: Available evidence suggests that cimetidine is a reproductive toxicant that induces sexual and testicular dysfunction. Ocimum gratissimum (OG) is globally consumed for medicinal and nutritional purposes. To determine the modulating role of aqueous leaf extract of Ocimum gratissimum on cimetidine-induced gonado-toxicity, sexually mature male rats were randomized into four groups of six (n=6) rats each. Group A: control given 2ml distilled water. Group B received 500mg/kg body weight (bwt) of OG extract, Group C received 50mg/kg bwt cimetidine, and group D received 50mg/kg bwt of cimetidine+500mg/kg bwt OG extract once daily for 8 weeks via gastric gavage...
January 28, 2022: Revista Internacional de Andrología
https://read.qxmd.com/read/34776394/comparative-assessment-of-immunochromatography-and-elisa-diagnostic-tests-for-hbsag-detection-in-pcr-confirmed-hbv-infection
#10
JOURNAL ARTICLE
N Navvabi, M H Khadem Ansari, A Navvabi, H R Chalipa, F Zitricky
INTRODUCTION AND AIMS: Viral hepatitis, which appears most frequently at birth or during childhood, is a disease whose transmission routes include tears, bile, sexual fluids, sweat, milk, urine, feces, and saliva. The aim of the present study was to analyze the specificity of the immunochromatographic and ELISA diagnostic tests for hepatitis B surface antigen and compare them with PCR testing. MATERIALS AND METHODS: The study sample was made up of 140 men and 60 women referred to the Urmia Medical University hospital to undergo PCR testing for HBV diagnosis...
November 11, 2021: Revista de Gastroenterología de México
https://read.qxmd.com/read/34751326/-effect-of-angiotensin-converting-enzyme-2-rs1978124-gene-polymorphism-on-the-hemodynamic-response-to-exercise
#11
JOURNAL ARTICLE
Nacim Molina-Gutiérrez, Sandra Becerra-Muñoz, Alejandro Pacheco-Valles
BACKGROUND: Angiotensin-converting enzyme 2 (ACE2) has a protective role in the regulation of blood pressure. AIM: To evaluate the influence of ACE2 rs1978124 gene polymorphism on the hemodynamic response after a six-minute walk submaximal aerobic test. MATERIAL AND METHODS: A six-minute walk submaximal aerobic test was carried out in 47 men and 55 women, aged 22 ± 2 years. Blood pressure was recorded before and after the test. Pulse rate was recorded continuously...
May 2021: Revista Médica de Chile
https://read.qxmd.com/read/34751306/-pharmacokinetic-interactions-of-fruit-juices-and-herbal-preparations
#12
REVIEW
Matías Cortés, Rodrigo Díaz, Samuel Verdugo, Salvador Cabrera, Pablo Torres-Vergara
Drug disposition in the human body is strongly influenced by transporters and metabolizing enzymes expressed in key organs including intestine, liver and kidney. Since drugs and chemicals present in foods such as fruit juices and herb-based products are substrates of the above-mentioned proteins, there is a high probability of pharmacokinetic interactions. Findings from preclinical and clinical studies helped to characterize the mechanisms by which the components of fruit juices and herbs act as perpetrators of pharmacokinetic interactions...
July 2021: Revista Médica de Chile
https://read.qxmd.com/read/34559488/retrospective-pharmacogenetic-analysis-of-a-pediatric-patient-under-anticoagulant-treatment-clinical-case
#13
JOURNAL ARTICLE
Mirta Cavieres, Marcelo Suárez, Gabriel Verón, Luis Abel Quiñones, Nelson Miguel Varela
We present the clinical case of a 10-year-old patient diagnosed with dilated cardiomyopathy who registered INR values above 10 upon receiving standard doses of acenocoumarol, as well as other values reported as uncoagulable, forcing the discontinuation and restart of treatment more than once. Expected and stable INR levels were achieved after more than 30 days of treatment, surprisingly with half the recommended dose for a patient of her age and weight. We decided to conduct a retrospective pharmacogenomic analysis including nucleotide genetic polymorphisms (SNPs) with different degrees of association with the dose/response to antivitamin K (AVK) drugs: rs2108622 (gene CYP4F2), rs9923231, rs7294 (gene VKORC1), rs1799853, and rs1057910 (CYP2C9 gene) using TaqMan® RT-PCR...
September 22, 2021: Biomédica: Revista del Instituto Nacional de Salud
https://read.qxmd.com/read/34495114/-historical-construction-of-the-concept-of-the-enzyme-and-approaches-in-biology-textbooks
#14
JOURNAL ARTICLE
Paulo Newton Tonolli, Fernando Faria Franco, Antônio Fernando Gouvêa Silva
The use of the history and philosophy of science in teaching and learning is commonly neglected, linear, and/or out of context in textbooks. This article investigates whether this also occurs with the concept of enzymes. A brief review of the literature establishes the theoretical foundation to investigate how the concept of enzymes is presented in nine textbooks, following three different lines of analysis. A general lack of interconnection was seen in biochemistry topics, with enzymes usually only presented via the "lock-and-key" model, which does not best represent their complexity...
July 2021: História, Ciências, Saúde—Manguinhos
https://read.qxmd.com/read/34171108/cannabinoid-receptor-type-2-gene-is-associated-with-comorbidity-of-schizophrenia-and-cannabis-dependence-and-fatty-acid-amide-hydrolase-gene-is-associated-with-cannabis-dependence-in-the-spanish-population
#15
JOURNAL ARTICLE
Francisco Arias Horcajadas, José Ramón Dávila Píriz, Alba Parra González, Sergio Sánchez Romero, Eva Sánchez-Morla, Israel Ampuero Sánchez, José Antonio Ramos Atance
The endocannabinoid system has been associated with various psychiatric disorders, such as schizophrenia or addictive disorders. Recent studies have found that some polymorphisms in the cannabinoid receptor type 2 (CNR2), cannabinoid receptor type 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes could play an important role as risk factors in the etiology of these diseases. We analysed different cannabinoid gene polimorphisms from non-substance using patients diagnosed with schizophrenia (n = 379), schizophrenic patients with cannabis use disorders (n = 124), cannabis users who did not have psychoses (n = 71), and 316 controls from various Spanish hospitals and health centres...
June 15, 2021: Adicciones
https://read.qxmd.com/read/34125803/is-clostridioides-difficile-toxins-detection-necessary-when-the-glutamate-dehydrogenase-enzyme-is-detected
#16
JOURNAL ARTICLE
José F García-Fuentes, Brenda J Torres-Murillo, Gilberto Aguilar-Orozco, Élida González, Juan L Mosqueda, Alejandro E Macías, José A Álvarez
INTRODUCTION: Clostridioides difficile causes diarrhea and pseudomembranous colitis. Its diagnosis is made with glutamate dehydrogenase (GDH) or toxins A and B detection and is confirmed with nucleic acid amplification tests. OBJECTIVE: To define if GDH determination is redundant to that of toxins. METHODS: Retrospective, observational study in diarrheal stools of patients with suspected Clostridioides difficile infection. Toxins and GDH were determined by immunochromatography...
2021: Gaceta Médica de México
https://read.qxmd.com/read/34090632/evaluation-of-liver-function-tests-in-the-paediatric-patient
#17
JOURNAL ARTICLE
Víctor Fernández Ventureira, Ignacio Ros Arnal, Gerardo Rodríguez Martínez, Beatriz García Rodríguez, Ruth García Romero, Eduardo Ubalde Sainz
INTRODUCTION: Although changes in liver function tests can be non-specific in numerous clinical conditions, they can be the first sign of a potentially serious disease in an asymptomatic patient. MATERIAL AND METHODS: Retrospective cohort study, performed by reviewing the records of children of a reference hospital central laboratory with alanine aminotransferase enzyme (ALT) elevation during a 6-month aleatory period. RESULTS: 572 blood tests with serum ALT elevation corresponding to 403 patients have been assessed during the period studied...
June 2021: Anales de pediatría
https://read.qxmd.com/read/34088524/chronic-use-of-renin-angiotensin-aldosterone-inhibitors-in-hypertensive-covid-19-patients-results-from-a-spanish-registry-and-meta-analysis
#18
JOURNAL ARTICLE
Álvaro Aparisi, Pablo Catalá, Ignacio J Amat-Santos, Marta Marcos-Mangas, Diego López-Otero, Carlos Veras, Javier López-Pais, Gonzalo Cabezón-Villalba, Carla Eugenia Cacho Antonio, Jordi Candela, Pablo Antúnez-Muiños, José Francisco Gil, Teba González Ferrero, Gino Rojas, Marta Pérez-Poza, Aitor Uribarri, Oscar Otero-García, Pablo Elpidio García-Granja, Víctor Jiménez Ramos, Ana Revilla, Carlos Dueñas, Itzíar Gómez, José Ramón González-Juanatey, J Alberto San Román
BACKGROUND: Hypertension is a prevalent condition among SARS-CoV-2 infected patients. Whether renin-angiotensin-aldosterone system (RAAS) inhibitors are beneficial or harmful is controversial. METHODS: We have performed a national retrospective, nonexperimental comparative study from two tertiary hospitals to evaluate the impact of chronic use of RAAS inhibitors in hypertensive COVID-19 patients. A meta-analysis was performed to strengthen our findings. RESULTS: Of 849 patients, 422 (49...
May 6, 2021: Medicina Clínica
https://read.qxmd.com/read/33871468/covid-19-from-a-cardiovascular-perspective
#19
JOURNAL ARTICLE
Alfonso Bryce-Moncloa, Mayte Bryce-Alberti, Arianna Portmann-Baracco, Juan Urquiaga-Calderón, César Larrauri-Vigna, Edmundo Alegría-Valdivia
Currently, myocardial injury has been reported in patients hospitalized with coronavirus disease 2019 (COVID-19). The studies also show a correlation between cardiac events and severe forms of the disease. COVID-19 begins with an early infection phase in which the virus infiltrates the lung parenchyma and proliferates. It then progresses to the pulmonary phase, where the initial inflammatory process, characterized by vasodilation, vascular permeability, and leukocyte recruitment, leads to lung damage, hypoxemia, and cardiovascular stress...
December 20, 2021: Archivos de Cardiología de México
https://read.qxmd.com/read/33761188/an-outbreak-of-salmonella-enterica-subsp-enterica-serovar-give-associated-with-foodborne-illness-in-the-department-of-vichada-colombia-2015
#20
JOURNAL ARTICLE
Nancy Yaneth Flórez, Stefany Alejandra Arévalo, Edna Catering Rodríguez, Jaime Guerrero, Kelly Paola Valverde, Paula Lucía Díaz, Lucy Angeline Montaño, Doris Mabel Gartner, Carolina Duarte, Jaime Enrique Moreno
Introduction: Salmonella enterica subsp. enterica serovar Give is found in ruminants, pigs, poultry, and aquatic environments, but rarely in humans. In Colombia, this serotype was ranked 11th. in the laboratory surveillance of acute diarrheal disease between 2000 and 2013. Objective: To characterize phenotypic and genotypic isolates of Salmonella related to an outbreak of foodborne Illness in the department Vichada in the fifth epidemiological week of 2015. Materials and methods: Following the Instituto Nacional de Salud method, we tested 37 fecal samples for Salmonella spp...
March 19, 2021: Biomédica: Revista del Instituto Nacional de Salud
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