Wenquan Wang, Jingxia Zheng, Xiaojing Hong, Jiaying Zhou, Yuwen Xiong, Hailong Yang, Shengnan Li, Guoqi Chen, Qiao Su, Wenwen Li, Bin Cheng, Jun Fu, Tong Wu
The clinical treatment of chronic diabetic wounds is a long-standing thorny issue. Strategies targeting the diabetic micro-environment have been developed to promote wound healing. However, it remains challenging to reverse the adverse conditions and re-activate tissue regeneration and angiogenesis. In this work, we develop injectable hydrogels that are responsive to acidic conditions, reactive oxygen species (ROS), and high glucose levels in a diabetic wound micro-environment to sustainably deliver tannic acid (TA) to augment antibacterial, anti-inflammatory, and anti-oxidative activities...
April 24, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine