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https://www.readbyqxmd.com/read/29904200/developing-an-evidence-based-approach-for-antimicrobial-resistance-reporting-for-british-columbia-diagnostic-animal-health-laboratory-data
#1
Theresa Burns, Brian R Radke, Tyler Stitt, Carl Ribble
Antimicrobial resistance (AMR) data generated by diagnostic animal health laboratories are underutilized for AMR reporting in Canada. Data assessment, review of practices in other jurisdictions, and expert interviews were used to develop an evidence-guided plan to generate AMR reports from British Columbia Animal Health Centre (AHC) data that would provide transparent, timely, and useful information to public health practitioners, the food animal sector, and the general public. Using the Canadian Animal Health Surveillance Network (CAHSN) platform was the most efficient method of data retrieval...
May 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29900089/staphylococcus-lugdunensis-endocarditis-and-cerebrovascular-accident-a-systemic-review-of-risk-factors-and-clinical-outcome
#2
REVIEW
Htoo Kyaw, Felix Raju, Atif Z Shaikh, Aung Naing Lin, Aye T Lin, Joseph Abboud, Sarath Reddy
Infective endocarditis (IE) secondary to Staphylococcus lugdunensis has been increasingly recognized since 1988. IE-related thromboembolism represents an associated complication of the disease and carries a dismal prognosis. However, the incidence of cerebrovascular accident secondary to S. lugdunensis IE is relatively uncommon and its treatment has not been clearly elucidated yet. We performed an extensive literature search using Pubmed, Medline, Scopus, and Google Scholar to identify the articles using the following keywords: 'Staphylococcus lugdunensis', 'infective endocarditis', 'stroke', and 'cerebrovascular accident...
April 12, 2018: Curēus
https://www.readbyqxmd.com/read/29894240/laboratory-data-as-a-quality-indicator-of-health-care-associated-infections-in-england
#3
Dakshika Jeyaratnam, Timothy Planche
Routine diagnostic laboratory results, e.g. numbers of meticillin-resistant Staphylococcus aureus (MRSA) bacteraemias, have been used as health-care-associated infection quality indicators for decades. The English health-care-associated infection quality indicator system was one of the earliest in the world to mandate the collection and public reporting of such data and has been associated with a reduction of MRSA bacteraemias and Clostridium difficile infections but has shown mixed results for other infections...
June 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29889859/global-etiology-of-bacterial-meningitis-a-systematic-review-and-meta-analysis
#4
Anouk M Oordt-Speets, Renee Bolijn, Rosa C van Hoorn, Amit Bhavsar, Moe H Kyaw
Bacterial meningitis is a global public health concern, with several responsible etiologic agents that vary by age group and geographical area. The aim of this systematic review and meta-analysis was to assess the etiology of bacterial meningitis in different age groups across global regions. PubMed and EMBASE were systematically searched for English language studies on bacterial meningitis, limited to articles published in the last five years. The methodological quality of the studies was assessed using a customized scoring system...
2018: PloS One
https://www.readbyqxmd.com/read/29887505/foodborne-pathogens-in-unpasteurized-milk-in-sweden
#5
Karin Artursson, Jenny Schelin, Susanne Thisted Lambertz, Ingrid Hansson, Eva Olsson Engvall
Raw milk may be a risk for public health if it is contaminated with zoonotic pathogens. To study the prevalence in unpasteurized milk from Swedish farms, bovine and small ruminant dairy farms were sampled. Since the sampling method and transport conditions may influence the outcome of analyses, efforts were made to optimize the methodology. Culturing of bacteria was done from in-line milk filters collected from the milk pipe at the point where it enters the milk bulk tank at the farms and this way of sampling was compared to sampling bulk tank milk (BTM) directly...
May 19, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29879096/invasive-methicillin-resistant-staphylococcus-aureus-infections-among-persons-who-inject-drugs-six-sites-2005-2016
#6
Kelly A Jackson, Michele K Bohm, John T Brooks, Alice Asher, Joelle Nadle, Wendy M Bamberg, Sue Petit, Susan M Ray, Lee H Harrison, Ruth Lynfield, Ghinwa Dumyati, William Schaffner, John M Townes, Isaac See
In the United States, age-adjusted opioid overdose death rates increased by >200% during 1999-2015, and heroin overdose death rates increased nearly 300% during 2011-2015 (1). During 2011-2013, the rate of heroin use within the past year among U.S. residents aged ≥12 years increased 62.5% overall and 114.3% among non-Hispanic whites, compared with 2002-2004 (2). Increases in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections related to increases in injection drug use have been recently highlighted (3,4); likewise, invasive bacterial infections, including endocarditis, osteomyelitis, and skin and soft tissue infections, have increased in areas where the opioid epidemic is expanding (5-7)...
June 8, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29877733/methicillin-resistant-staphylococcus-aureus-in-poultry-and-poultry-meat-a-meta-analysis
#7
Claudia M Ribeiro, Lenita M Stefani, Simone B Lucheis, Werner Okano, Juliano Cezar M Cruz, Guilherme V Souza, Thais A C Casagrande, Paula Andrea S Bastos, Rafael R Pinheiro, Mauro M Arruda, Vera Afreixo
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that colonizes and infects various host species and has been found in the poultry production chain, raising concerns about possible transmission from farm to fork. The objective of this study was to use meta-analytical methods to estimate the pooled prevalence of MRSA in chickens, turkeys, chicken meat, and turkey meat. Three electronic databases (PubMed, LILACS, and SciELO) were searched to establish MRSA prevalence from 51 studies published from 2003 through May 2017...
June 7, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29870274/engineered-ef-tu-and-trna-based-fret-screening-assay-to-find-inhibitors-of-protein-synthesis-in-bacteria
#8
Rachana Bhatt, Maxim Chudaev, Wlodek Mandecki, Emanuel Goldman
Antibiotic-resistant infections that do not respond to available drugs are becoming more common. Methicillin-resistant Staphylococcus aureus, carbapenem-resistant enterobacteria ("superbugs"), and many others pose a continuous threat to public health. To provide tools to combat such deadly infections, we present in this study a homogeneous assay focused on an insufficiently addressed molecular interaction linked to ribosomal translation. We show that a fluorescence resonance energy transfer (FRET) based screening assay can identify antibiotic molecules that inhibit ternary complex (EF-Tu:tRNA:GTP complex) formation, and therefore, protein synthesis in bacteria...
June 5, 2018: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/29866769/innate-immunity-to-staphylococcus-aureus-evolving-paradigms-in-soft-tissue-and-invasive-infections
#9
REVIEW
Stephanie L Brandt, Nicole E Putnam, James E Cassat, C Henrique Serezani
Staphylococcus aureus causes a wide range of diseases that together embody a significant public health burden. Aided by metabolic flexibility and a large virulence repertoire, S. aureus has the remarkable ability to hematogenously disseminate and infect various tissues, including skin, lung, heart, and bone, among others. The hallmark lesions of invasive staphylococcal infections, abscesses, simultaneously denote the powerful innate immune responses to tissue invasion as well as the ability of staphylococci to persist within these lesions...
June 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29866473/mechanomicrobiology-how-mechanical-forces-activate-staphylococcus-aureus-adhesion
#10
Joan A Geoghegan, Yves F Dufrêne
During colonization of biomaterials and host tissues, surface-attached bacteria are subjected to mechanical stresses, including hydrodynamic flow and cell-surface contacts. Two publications show that mechanical force activates the adhesive function of Staphylococcus aureus surface proteins, thereby providing the pathogen with a means to withstand high shear stress during colonization.
June 1, 2018: Trends in Microbiology
https://www.readbyqxmd.com/read/29866270/a-film-based-integrated-chip-for-gene-amplification-and-electrochemical-detection-of-pathogens-causing-foodborne-illnesses
#11
Yoo Min Park, Sun Young Lim, Su Jeong Shin, Chi Hyun Kim, Soon Woo Jeong, Seol Yi Shin, Nam Ho Bae, Seok Jae Lee, Jeongkyeong Na, Gyoo Yeol Jung, Tae Jae Lee
Given the increased interest in public hygiene due to outbreaks of food poisoning, increased emphasis has been placed on developing novel monitoring systems for point-of-care testing (POCT) to evaluate pathogens causing foodborne illnesses. Here, we demonstrate a pathogen evaluation system utilizing simple film-based microfluidics, featuring simultaneous gene amplification, solution mixing, and electrochemical detection. To minimize and integrate the various functionalities into a single chip, patterned polyimide and polyester films were mainly used on a polycarbonate housing chip, allowing simple fabrication and alignment, in contrast to conventional polymerase chain reaction, which requires a complex biosensing system at a bench-top scale...
October 16, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29858939/occurrence-of-anthropozoonotic-parasitic-infections-and-faecal-microbes-in-free-ranging-sperm-whales-physeter-macrocephalus-from-the-mediterranean-sea
#12
Carlos Hermosilla, J Hirzmann, L M R Silva, J M Brotons, M Cerdà, E Prenger-Berninghoff, C Ewers, A Taubert
Sperm whales (Physeter macrocephalus) are the largest toothed whales and only living member of family Physeteridae. Present survey represents first report on cultivable faecal microbes and gastrointestinal helminths and protozoans infecting free-ranging sperm whales inhabiting Mediterranean Sea waters surrounding Balearic Archipelago, Spain. Twenty-five individual sperm whale scat samples, including one calf, were collected without disturbance of animals during the summer of 2016. Parasitological diagnostic methods, such as sodium acetate acetic formalin (SAF) method, carbol fuchsin-stained faecal smears, Giardia/Cryptosporidium coproantigen ELISAs and an Anisakis-specific PCR were applied for further identification...
June 1, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29848316/in-vitro-antibacterial-effects-of-tanreqing-injection-combined-with-vancomycin-or-linezolid-against-methicillin-resistant-staphylococcus-aureus
#13
Weifeng Yang, Jueling Liu, Biljana Blažeković, Yanan Sun, Shuhua Ma, Chuanyun Ren, Sanda Vladimir-Knežević, Chaohua Li, Yajun Xing, Guijie Tian, Yi Wang
BACKGROUND: Combining conventional drugs and traditional medicine may represent a useful approach to combating antibiotic resistance, which has become a serious threat to global public health. This study aimed to evaluate the potential synergistic interactions between Tanreqing (TRQ) injection, a commercial traditional Chinese medicine formula used for the treatment of upper respiratory tract infection, and selected antibiotics used against methicillin-resistant Staphylococcus aureus (MRSA)...
May 30, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29845657/green-fabrication-of-amphiphilic-quaternized-%C3%AE-chitin-derivatives-with-excellent-biocompatibility-and-antibacterial-activities-for-wound-healing
#14
Huan Xu, Zehong Fang, Weiqun Tian, Yanfeng Wang, Qifa Ye, Lina Zhang, Jie Cai
Bacterial infection has always been a great threat to public health, and new antimicrobials to combat it are urgently needed. Here, a series of quaternized β-chitin derivatives is prepared simply and homogeneously in an aqueous KOH/urea solution, which is a high-efficiency, energy-saving, and "green" route for the modification of chitin. The mild reaction conditions keep the acetamido groups of β-chitin intact and introduce quaternary ammonium groups on the primary hydroxyl at the C-6 position of the chitin backbone, allowing the quaternized β-chitin derivatives (QCs) to easily form micelles...
May 29, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29805074/elucidating-the-inhibition-of-peptidoglycan-biosynthesis-in-staphylococcus-aureus-by-albocycline-a-macrolactone-isolated-from-streptomyces-maizeus
#15
Hai Liang, Guangfeng Zhou, Yunhui Ge, Elizabeth A D'Ambrosio, Tess M Eidem, Catlyn Blanchard, Cindy Shehatou, Vijay K Chatare, Paul M Dunman, Ann M Valentine, Vincent A Voelz, Catherine L Grimes, Rodrigo B Andrade
Antibiotic resistance is a serious threat to global public health, and methicillin-resistant Staphylococcus aureus (MRSA) is a poignant example. The macrolactone natural product albocycline, derived from various Streptomyces strains, was recently identified as a promising antibiotic candidate for the treatment of both MRSA and vancomycin-resistant S. aureus (VRSA), which is another clinically relevant and antibiotic resistant strain. Moreover, it was hypothesized that albocycline's antimicrobial activity was derived from the inhibition of peptidoglycan (i...
May 24, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29802728/detection-of-enterotoxin-genes-and-methicillin-resistance-in-staphylococcus-aureus-isolated-from-water-buffalo-milk-and-dairy-products
#16
Erdem Saka, Goknur Terzi Gulel
The aim of this study was to analyze the presence of genes encoding staphylococcal enterotoxins and methicillin resistance in Staphylococcus aureus isolates obtained from water buffalo milk and dairy products. A total of 200 samples (100 raw milk, 50 clotted cream, and 50 cheese samples) was collected from different dairy farms and smallholders in Samsun, Turkey. All samples were analyzed using the standard procedure EN ISO 6888-1 and isolates were confirmed for the presence of the target 16S rRNA specific for Staphylococcus genus specific and nuc gene specific for S...
May 26, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29796901/rapid-detection-and-differentiation-of-staphylococcus-colonies-using-an-optical-scattering-technology
#17
Tawfiq S Alsulami, Xingyue Zhu, Maha Usama Abdelhaseib, Atul K Singh, Arun K Bhunia
Staphylococcus species are a major pathogen responsible for nosocomial infections and foodborne illnesses. We applied a laser-based BARDOT (bacterial rapid detection using optical scattering technology) for rapid colony screening and detection of Staphylococcus on an agar plate and differentiate these from non-Staphylococcus spp. Among the six growth media tested, phenol red mannitol agar (PRMA) was found most suitable for building the Staphylococcus species scatter image libraries. Scatter image library for Staphylococcus species gave a high positive predictive value (PPV 87...
May 24, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29795120/antimicrobial-and-anti-biofilm-activity-of-hexadentated-macrocyclic-complex-of-copper-ii-derived-from-thiosemicarbazide-against-staphylococcus-aureus
#18
Umarani Brahma, Richa Kothari, Paresh Sharma, Vasundhra Bhandari
Multidrug-resistant pathogens causing nosocomial and community acquired infections delineate a significant threat to public health. It had urged to identify new antimicrobials and thus, generated interest in studying macrocyclic metal complex, which has been studied in the past for their antimicrobial activity. Hence, in the present study, we have evaluated the antimicrobial activity of the hexadentated macrocyclic complex of copper (II) (Cu Complex) derived from thiosemicarbazide against Gram-positive and Gram-negative bacteria...
May 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29788897/biofilm-destruction-on-endotracheal-tube-associated-pneumonia-by-photodynamic-inactivation
#19
Kate Cristina Blanco, Amanda C Zangirolami, Natalia M Inada, Vanderlei S Bagnato
Hospital infections is a public health problem that can occur with the use of catheters and endotracheal tubes (ETT). Pathogenic microorganisms may adhere to surfaces of these materials forming biofilm. Microbial biofilms presents an extracellular polymer matrix that promotes resistance of microorganisms to factors such as pH, temperature and drugs. The ETT is used to assist a patient with compromised breathing function. ETT biofilm may cause ventilator-associated pneumonia. Pseudomonas aeruginosa and Staphylococcus aureus pneumonia is associated with a 21-fold increase in risk for mechanical ventilation...
May 22, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29784342/rapid-and-sensitive-detection-of-staphylococcus-aureus-assisted-by-polydopamine-modified-magnetic-nanoparticles
#20
Xiaomei Gao, Xin Yao, Zitao Zhong, Li Jia
Pathogens cause significant morbidity and mortality to humans. Thus, development of fast and reliable methods for detection and identification of pathogens is urgently needed to increase protection level of public health and ensure the safety of consumers. Herein, a rapid and sensitive method has been developed for Staphylococcus aureus (S. aureus) detection based on the dual role of polydopamine modified magnetic nanoparticles (PDA@Fe3 O4 NPs) combined with polymerase chain reaction (PCR) and capillary electrophoresis (CE)...
August 15, 2018: Talanta
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