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https://www.readbyqxmd.com/read/28806774/fibroblast-growth-factor-receptor-1-mediates-internalization-of-pathogenic-spotted-fever-rickettsiae-into-host-endothelium
#1
Abha Sahni, Jignesh Patel, Hema P Narra, Casey L C Schroeder, David H Walker, Sanjeev K Sahni
Rickettsial infections continue to cause serious morbidity and mortality in severe human cases around the world. Host cell adhesion and invasion is an essential requisite for intracellular growth, replication, and subsequent dissemination of pathogenic rickettsiae. Heparan sulfate proteoglycans [HSPGs] facilitate the interactions between fibroblast growth factor(s) and their tyrosine kinase receptors resulting in receptor dimerization/activation and have been implicated in bacterial adhesion to target host cells...
2017: PloS One
https://www.readbyqxmd.com/read/28805302/torix-group-rickettsia-are-widespread-in-culicoides-biting-midges-diptera-ceratopogonidae-reach-high-frequency-and-carry-unique-genomic-features
#2
Jack Pilgrim, Mats Ander, Claire Garros, Matthew Baylis, Gregory D D Hurst, Stefanos Siozios
There is increasing interest in the heritable bacteria of invertebrate vectors of disease as they present novel targets for control initiatives. Previous studies on biting midges (Culicoides spp.), known to transmit several RNA viruses of veterinary importance, have revealed infections with the endosymbiotic bacteria, Wolbachia and Cardinium. However, rickettsial symbionts in these vectors are underexplored. Here, we present the genome of a previously uncharacterized Rickettsia endosymbiont from Culicoides newsteadi (RiCNE)...
August 14, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28774495/wild-and-domestic-animals-likely-involved-in-rickettsial-endemic-zones-of-northwestern-colombia
#3
Andrés F Londoño, Leidy Y Acevedo-Gutiérrez, Diana Marín, Verónica Contreras, Francisco J Díaz, Gustavo Valbuena, Marcelo B Labruna, Marylin Hidalgo, Margarita Arboleda, Salim Mattar, Sergio Solari, Juan D Rodas
Between 2006 and 2008, three outbreaks of human rickettsiosis occurred in Northwestern Colombia (municipalities of Necoclí, Los Córdobas and Turbo), with case fatality rates between 27% and 54%. The aim of this study was to determine previous exposure of wild and domestic animals to spotted fever group (SFG) rickettsiae through serological tests, to detect rickettsial evidence in their ectoparasites, and to analyze their possible role in the epidemiology of rickettsial diseases in this zone of the country...
July 21, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28770333/immune-response-against-rickettsiae-lessons-from-murine-infection-models
#4
REVIEW
Anke Osterloh
Rickettsiae are small intracellular bacteria that can cause life-threatening febrile diseases. Rickettsioses occur worldwide with increasing incidence. Therefore, a vaccine is highly desired. A prerequisite for the development of a vaccine is the knowledge of the immune response against these bacteria, in particular protective immunity. In recent years murine models of rickettsial infections have been established, and the study of immune response against rickettsiae in mice provided many new insights into protective and pathological immune reactions...
August 2, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28764157/seroepidemiology-of-spotted-fever-rickettsiosis-in-uttar-pradesh-a-prospective-study
#5
Chandra Dev Pati Tripathi, Mastan Singh, Jyotsna Agarwal, Chandra Kanta, Virendra Atam
INTRODUCTION: Spotted Fever Rickettsiosis (SFR), an acute febrile illness caused by Rickettsia rickettsii, R. conorii and R. akari which is associated with considerable morbidity and mortality. SFR is one of the most covert emerging infections of the present time which is prevalent in various parts of India as shown by the increase in the number of clinically diagnosed patients in various states except Uttar Pradesh. AIM: To diagnose SFR in clinically suspected patients using serological tests and recognition of common epidemiologic situations and clinical manifestations of SFR in the state of Uttar Pradesh...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28752684/amblyomma-sculptum-genetic-diversity-and-rickettsias-in-the-brazilian-cerrado-biome
#6
K Bitencourth, M Amorim, S V DE Oliveira, R L Caetano, C M Voloch, G S Gazêta
Amblyomma sculptum (Ixodida: Ixodidae) Berlese, 1888 is the most important tick vector in Brazil, transmitting the bioagent of the most severe form of spotted fever (SF) in part of the Cerrado (in the states of Minas Gerais and São Paulo). In another part of the Cerrado (Central-West region of Brazil), a milder form of SF has been recorded. However, neither the rickettsia nor the vector involved have been characterized. The aim of the current study was to analyse genetic variation and the presence of rickettsia in A...
July 28, 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/28750865/human-head-lice-and-pubic-lice-reveal-the-presence-of-several-acinetobacter-species-in-algiers-algeria
#7
Nassima Mana, Meriem Louni, Philippe Parola, Idir Bitam
There are two majorspecies of medically important lice that parasitize humans: Phthirus pubis, found in pubic hair, and Pediculus humanus. Pediculus humanus consists of two eco types that live in specific niches on the human host: body lice (Pediculus humanus humanus), found on the human body and clothing, and head lice (Pediculus humanus capitis), found on the scalp. To date, only body lice are known to be vectors of human disease; however, it has recently been reported that the DNA of several bacterial agents has been detected in head lice, raising questions about their role in the transmission of pathogens...
August 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28750863/microscopic-and-molecular-identification-of-hemotropic-mycoplasmas-in-south-american-coatis-nasua-nasua
#8
Michelle P Cubilla, Leonilda C Santos, Wanderlei de Moraes, Zalmir S Cubas, Christian M Leutenegger, Marko Estrada, LeAnn L Lindsay, Edvaldo S Trindade, Célia Regina C Franco, Rafael F C Vieira, Alexander W Biondo, Jane E Sykes
Hemoplasmas were detected in two apparently healthy captive South American coatis (Nasua nasua) from southern Brazil during an investigation for vector-borne pathogens. Blood was subjected to packed cell volume (PCV) determination, a commercial real-time PCR panel for the detection of Anaplasma spp., Babesia spp., Bartonella spp., Hepatozoon spp., Leishmania spp., Mycoplasma haemofelis, 'Candidatus Mycoplasma turicensis', 'Candidatus Mycoplasma haemominutum', Neorickettsia risticii, Rickettsia rickettsii and Leptospira spp...
August 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28748844/spotted-fever-rickettsiae-and-tuberculous-meningitis-dual-infection-presenting-as-acute-encephalitis-syndrome-a-fatal-case-report
#9
Siraj A Khan, Trishna Bora, Sakir Ahmed, Sayyed M I S Malang, Utpala Devi, Sanjeev Kakati, Prafulla Dutta
No abstract text is available yet for this article.
April 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28742123/molecular-and-maldi-tof-identification-of-ticks-and-tick-associated-bacteria-in-mali
#10
COMPARATIVE STUDY
Adama Zan Diarra, Lionel Almeras, Maureen Laroche, Jean-Michel Berenger, Abdoulaye K Koné, Zakaria Bocoum, Abdoulaye Dabo, Ogobara Doumbo, Didier Raoult, Philippe Parola
Ticks are considered the second vector of human and animal diseases after mosquitoes. Therefore, identification of ticks and associated pathogens is an important step in the management of these vectors. In recent years, Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been reported as a promising method for the identification of arthropods including ticks. The objective of this study was to improve the conditions for the preparation of tick samples for their identification by MALDI-TOF MS from field-collected ethanol-stored Malian samples and to evaluate the capacity of this technology to distinguish infected and uninfected ticks...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28739494/amblyomma-maculatum-secis-binding-protein-2-and-putative-selenoprotein-p-are-indispensable-for-pathogen-replication-and-tick-fecundity
#11
Khemraj Budachetri, Gary Crispell, Shahid Karim
Selenium, a vital trace element, is incorporated into selenoproteins to produce selenocysteine. Our previous studies have revealed an adaptive co-evolutionary process that has enabled the spotted fever-causing tick-borne pathogen Rickettsia parkeri to survive by manipulating an antioxidant defense system associated with selenium, which includes a full set of selenoproteins and other antioxidants in ticks. Here, we conducted a systemic investigation of SECIS binding protein 2 (SBP2) and putative selenoprotein P (SELENOP) by transcript silencing in adult female Gulf-coast ticks (Amblyomma maculatum)...
July 21, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28722610/evaluation-of-a-spotted-fever-group-rickettsia-public-health-surveillance-system-in-tennessee
#12
Mary-Margaret A Fill, Abelardo C Moncayo, Karen C Bloch, John R Dunn, William Schaffner, Timothy F Jones
Spotted fever group (SFG) rickettsioses are endemic in Tennessee, with ∼2,500 cases reported during 2000-2012. Because of this substantial burden of disease, we performed a three-part evaluation of Tennessee's routine surveillance for SFG rickettsioses cases and deaths to assess the system's effectiveness. Tennessee Department of Health (TDH) SFG rickettsioses surveillance records were matched to three patient series: 1) patients with positive serologic specimens from a commercial reference laboratory during 2010-2011, 2) tertiary medical center patients with positive serologic tests during 2007-2013, and 3) patients identified from death certificates issued during 1995-2014 with SFG rickettsiosis-related causes of death...
July 3, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722591/serological-evidence-of-rickettsia-spp-in-western-australian-dogs
#13
Mark David Bennett, Mohammad Yazid Abdad, John Stenos
It has been claimed that dogs can be useful sentinels for public health monitoring of vector-borne infectious diseases, including Rickettsia spp. We used 153 canine blood samples opportunistically collected at Murdoch University Veterinary Hospital and 156 canine sera collected from Aboriginal communities in northwest Western Australia to test for evidence of Rickettsia spp. exposure, using microimmunofluorescence (MIF) in the latter case, and both MIF and polymerase chain reaction (PCR) in the former. Conventional and real-time PCR failed to amplify any Rickettsia spp...
June 12, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722584/rocky-mountain-spotted-fever-and-pregnancy-four-cases-from-sonora-mexico
#14
Jesus David Licona-Enriquez, Jesus Delgado-de la Mora, Christopher D Paddock, Carlos Arturo Ramirez-Rodriguez, María Del Carmen Candia-Plata, Gerardo Álvarez Hernández
We present a series of four pregnant women with Rocky Mountain spotted fever (RMSF) that occurred in Sonora, Mexico, during 2015-2016. Confirmatory diagnoses were made by polymerase chain reaction or serological reactivity to antigens of Rickettsia rickettsii by using an indirect immunofluorescence antibody assay. Each patient presented with fever and petechial rash and was treated successfully with doxycycline. Each of the women and one full-term infant delivered at 36 weeks gestation survived the infection...
June 12, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722568/epidemiology-of-spotted-fever-group-rickettsioses-and-acute-undifferentiated-febrile-illness-in-villeta-colombia
#15
Álvaro A Faccini-Martínez, Alejandro Ramírez-Hernández, Christian Barreto, Elkin Forero-Becerra, Diego Millán, Elkin Valbuena, Andrea C Sánchez-Alfonso, Wilson O Imbacuán-Pantoja, Jesús A Cortés-Vecino, Luis J Polo-Terán, Néstor Yaya-Lancheros, Jorge Jácome, Ana M Palomar, Sonia Santibáñez, Aránzazu Portillo, José A Oteo, Marylin Hidalgo
Etiology of acute undifferentiated febrile syndrome (AUFS) is often unknown, leading to inaccurate diagnosis and treatment. Villeta town has been identified as an endemic area for spotted fever group (SFG) rickettsioses but little is known about possible amplifier hosts and other Rickettsia species different from Rickettsia rickettsii. Besides, few studies have approached other AUFS etiologies in the region. We investigated the role of dengue, leptospirosis, rickettsioses, human anaplasmosis, and Q fever as possible causes of AUFS in patients from Villeta...
June 19, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719297/rickettsia-australis-and-queensland-tick-typhus-a-rickettsial-spotted-fever-group-infection-in-australia
#16
Adam Stewart, Mark Armstrong, Stephen Graves, Krispin Hajkowicz
Rickettsia australis, the etiologic agent of Queensland tick typhus (QTT), is increasingly being recognized as a cause of community-acquired acute febrile illness in eastern Australia. Changing human population demographics, climate change, and increased understanding of expanding vector distribution indicate QTT is an emerging public health threat. This review summarizes the epidemiology, pathogenesis, clinical features, treatment principles, and future directions of this disease. Increased recognition of QTT will enable consideration of and prompt treatment of R...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28713577/seroprevalence-of-spotted-fever-group-sfg-rickettsiae-infection-in-domestic-ruminants-in-khartoum-state-sudan
#17
Nagwa M Eisawi, Dina A Hassan, Mohammed O Hussien, Azza B Musa, Abdel Rahim M El Hussein
Spotted fever group (SFG) rickettsiosis is caused by obligatory intracellular Gram-negative bacteria that belong to the genus Rickettsia. Ticks belonging to the family Ixodidae can act as vectors, reservoirs or amplifiers of SFG rickettsiae. This study was conducted to estimate the seroprevalence of SFG rickettsioses in cattle, sheep and goats from Khartoum State, Sudan. Blood samples were collected from a total of 600 animals (sheep, goats and cattle) from 32 different farms distributed in three locations in Khartoum State during the period January to December 2012...
May 2017: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/28710265/francisella-like-endosymbionts-and-rickettsia-species-in-local-and-imported-hyalomma-ticks
#18
Tal Azagi, Eyal Klement, Gidon Perlman, Yaniv Lustig, Kosta Y Mumcuoglu, Dmitry Apanaskevich, Yuval Gottlieb
Hyalomma ticks (Acari: Ixodidae) are hosts for Francisella like endosymbionts (FLE) and may serve as vectors of zoonotic disease agents. This study was aimed to provide initial characterization of the interaction between Hyalomma and FLE and to determine the prevalence of pathogenic Rickettsia in these ticks. Hyalomma marginatum, H. rufipes, H. dromedarii, H. aegyptium and H. excavatum ticks, identified morphologically and molecularly, were collected from different hosts and locations, representing the genus distribution in Israel, as well as from migratory birds...
July 14, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28709615/transcriptional-profiling-of-rickettsia-prowazekii-coding-and-non-coding-transcripts-during-in-vitro-host-pathogen-and-vector-pathogen-interactions
#19
Casey L C Schroeder, Hema P Narra, Abha Sahni, Kamil Khanipov, Jignesh Patel, Yuriy Fofanov, Sanjeev K Sahni
Natural pathogen transmission of Rickettsia prowazekii, the etiologic agent of epidemic typhus, to humans is associated with arthropods, including human body lice, ticks, and ectoparasites of eastern flying squirrel. Recently, we have documented the presence of small RNAs in Rickettsia species and expression of R. prowazekii sRNAs during infection of cultured human microvascular endothelial cells (HMECs), which represent the primary target cells during human infections. Bacterial noncoding transcripts are now well established as critical post-transcriptional regulators of virulence and adaptation mechanisms in varying host environments...
June 29, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28708277/first-detection-of-gas-bubble-disease-and-rickettsia-like-organisms-in-paphies-ventricosa-a-new-zealand-surf-clam
#20
P M Ross, A Pande, J B Jones, J Cope, G Flowers
No abstract text is available yet for this article.
July 14, 2017: Journal of Fish Diseases
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