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https://www.readbyqxmd.com/read/29577655/first-insights-into-puumala-orthohantavirus-circulation-in-a-rodent-population-in-alsace-france
#1
E Monchatre-Leroy, S Murri, G Castel, D Calavas, F Boué, V Hénaux, P Marianneau
In-depth knowledge on the mechanisms that maintain infection by a zoonotic pathogen in an animal reservoir is the key to predicting and preventing transmission to humans. The Puumala orthohantavirus (PUUV), the most prevalent orthohantavirus in Western Europe, causes a mild form of haemorrhagic fever with renal syndrome (HFRS) in humans. In France, this endemic illness affects the north-eastern part of the country. We conducted a 4-year capture-mark-recapture study in a bank vole population, combined with molecular analyses, to explore the epidemiological situation of PUUV in Alsace, a French region where human cases have occurred, but for which no studies have been conducted on this reservoir host...
March 25, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29413356/abnormal-lipoprotein-oxylipins-in-metabolic-syndrome-and-partial-correction-by-omega-3-fatty-acids
#2
Gregory C Shearer, Kamil Borkowski, Susan L Puumala, William S Harris, Theresa L Pedersen, John W Newman
Metabolic syndrome (MetSyn) is characterized by chronic inflammation which mediates the associated high risk for cardiovascular and other diseases. Oxylipins are a superclass of lipid mediators with potent bioactivities in inflammation, vascular biology, and more. While their role as locally produced agents is appreciated, most oxylipins in plasma are found in lipoproteins suggesting defective regulation of inflammation could be mediated by the elevated VLDL and low HDL levels characteristic of MetSyn. Our objective was to compare the oxylipin composition of VLDL, LDL, and HDL in 14 optimally healthy individuals and 31 MetSyn patients, and then to determine the effects of treating MetSyn subjects with 4g/day of prescription omega-3 fatty acids (P-OM3) on lipoprotein oxylipin profiles...
January 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29413094/vaccine-preventable-hospitalizations-among-american-indian-alaska-native-children-using-the-2012-kid-s-inpatient-database
#3
Amanda J Nickel, Susan E Puumala, Anupam B Kharbanda
Our aim was to assess the odds of hospitalization for a vaccine-preventable, infectious disease (VP-ID) in American Indian/Alaska Native (AI/AN) children compared to other racial and ethnic groups using the 2012 Kid's Inpatient Database (KID) The KID is a nationally representative sample, which allows for evaluation of VP-ID in a non-federal, non-Indian Health Service setting. In a cross-sectional analysis, we evaluated the association of race/ethnicity and a composite outcome of hospitalization due to vaccine-preventable infection using multivariate logistic regression...
February 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29404206/spatial-and-temporal-patterns-of-human-puumala-virus-puuv-infections-in-germany
#4
Sarah Cunze, Judith Kochmann, Thomas Kuhn, Raphael Frank, Dorian D Dörge, Sven Klimpel
Background: Worldwide, the number of recorded human hantavirus infections as well as the number of affected countries is on the rise. In Europe, most human hantavirus infections are caused by the Puumala virus (PUUV), with bank voles (Myodes glareolus) as reservoir hosts. Generally, infection outbreaks have been related to environmental conditions, particularly climatic conditions, food supply for the reservoir species and land use. However, although attempts have been made, the insufficient availability of environmental data is often hampering accurate temporal and spatially explicit models of human hantavirus infections...
2018: PeerJ
https://www.readbyqxmd.com/read/29351764/quantification-and-kinetics-of-viral-rna-transcripts-produced-in-orthohantavirus-infected-cells
#5
Julia Wigren Byström, Jonas Näslund, Fredrik Trulsson, Magnus Evander, Olivia Wesula Lwande, Clas Ahlm, Göran Bucht
BACKGROUND: Rodent borne viruses of the Orthohantavirus genus cause hemorrhagic fever with renal syndrome among people in Eurasia, and hantavirus cardiopulmonary syndrome in the Americas. At present, there are no specific treatments or efficient vaccines against these diseases. Improved understanding of viral transcription and replication may instigate targeted treatment of Orthohantavirus infections. For this purpose, we investigated the kinetics and levels of viral RNA transcription during an ongoing infection in-vitro...
January 19, 2018: Virology Journal
https://www.readbyqxmd.com/read/29310747/population-based-seroprevalence-of-puumala-hantavirus-in-finland-smoking-as-a-risk-factor
#6
F Latronico, S Mäki, H Rissanen, J Ollgren, O Lyytikäinen, O Vapalahti, J Sane
Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome in humans, that is an endemic disease in Finland. We estimated the seroprevalence of PUUV in Finland and explored risk factors and disease associations by using unique survey data with health register linkage. A total of 2000 sera from a nationwide health survey from 2011, representative of the adult population, were screened for PUUV IgG by immunofluorescence assay. We performed statistical analysis adjusting for stratified cluster design and taking into account sampling weights...
February 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29281106/delayed-interferon-type-1-induced-antiviral-state-is-a-potential-factor-for-hemorrhagic-fever-with-renal-syndrome-severity
#7
Katarina Resman Rus, Miša Korva, Petra Bogovic, Emil Pal, Franc Strle, Tatjana Avšic-Županc
Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in Europe and Asia. Interferon (IFN) responses play an important role in HFRS pathogenesis and early IFN-β response is delayed by pathogenic hantaviruses. The severity of HFRS caused by Dobrava virus (DOBV) and Puumala virus (PUUV) varies. Our aim was to determine whether differences in early activation of IFN type 1-induced antiviral state influence HFRS severity. Peripheral blood mononuclear cells (PBMCs) from healthy donors and HFRS patients were stimulated with DOBV or PUUV and expression of selected genes was measured...
March 5, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29204809/genesurance-counseling-genetic-counselors-roles-and-responsibilities-in-regards-to-genetic-insurance-and-financial-topics
#8
Shelby Brown, Susan Puumala, Jennifer Leonhard, Megan Bell, Jason Flanagan, Lori Williamson Dean, Quinn Stein
While traditional components of genetic counseling sessions are well recognized, less is known about insurance and financial discussions. This study sought to examine "genesurance counseling" which we defined as: that portion of a genetic counseling session, whether intentional or non-intentional, that is devoted to the topic of costs and insurance/third party coverage (particularly for genetic testing). Our objective was to assess genetic counselors' practices and perspective related to genesurance counseling...
December 4, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29101687/community-perspectives-on-emergency-department-use-and-care-for-american-indian-children
#9
Wyatt J Pickner, Katherine M Ziegler, Jessica D Hanson, Nathaniel R Payne, Heather G Zook, Anupam B Kharbanda, Tess L Weber, Jaymi N Russo, Susan E Puumala
Emergency department (ED) utilization by American Indian (AI) children is among the highest in the nation. Numerous health disparities have been well documented in AI children, but limited information is available on parental experiences of care for AI children in the ED. Our objective was to understand parental attitudes towards ED care for AI children. Focus groups were held with AI parents/caregivers at five sites in the Upper Midwest. Traditional content analysis was used to identify themes. A total of 70 parents participated in ten focus groups...
November 3, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29020303/risk-of-venous-thromboembolism-following-hemorrhagic-fever-with-renal-syndrome-a-self-controlled-case-series-study
#10
Anne-Marie Connolly-Andersen, Heather Whitaker, Jonas Klingström, Clas Ahlm
Background: Bleeding is associated with viral hemorrhagic fevers; however, thromboembolic complications have received less attention. Hemorrhagic fever with renal syndrome (HFRS) is a mild viral hemorrhagic fever caused by Puumala hantavirus. We previously identified HFRS as a risk factor for myocardial infarction and stroke, but the risk for venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is unknown. Methods: Personal identity numbers from the Swedish HFRS database were cross-linked with the National Patient register to obtain information on all causes for hospitalization during 1964 to 2013...
January 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28986730/acute-hantavirus-infection-presenting-as-haemolytic-uraemic-syndrome-hus-the-importance-of-early-clinical-diagnosis
#11
J Clement, A P K Lee, G A Verpooten, L Laenen, V Vergote, H De Samblanx, Z N Berneman, M Van Ranst, P Maes
The European prototype of hantavirus, Puumala virus (PUUV), isolated from a common wild rodent, the bank vole (Myodes glareolus), causes nephropathia epidemica (NE). NE can perfectly mimic haemolytic-uraemic syndrome (HUS), progressing from an aspecific flu-like syndrome to acute kidney injury with thrombocytopaenia, and presenting with some signs of haemolytic anaemia and/or coagulopathy. Moreover, both NE and HUS can occur in local outbreaks. We report an isolated case of NE, initially referred for plasmapheresis for suspected HUS, although signs of overt haemolysis were lacking...
January 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28968301/diminished-coagulation-capacity-assessed-by-calibrated-automated-thrombography-during-acute-puumala-hantavirus-infection
#12
Sirpa M Koskela, Lotta Joutsi-Korhonen, Satu M Mäkelä, Heini Huhtala, Antti I Vaheri, Ilkka Pörsti, Jukka T Mustonen, Outi K Laine
: Coagulation abnormalities are associated with Puumala-virus-induced hemorrhagic fever with renal syndrome (PUUV-HFRS). We evaluated the coagulation capacity of plasma during acute PUUV-HFRS by measuring thrombin generation using calibrated automated thrombography (CAT). The study cohort comprised 27 prospectively collected, consecutive, hospital-treated patients with acute PUUV infection. Blood samples were drawn in the acute phase and at the control visit approximately 5 weeks later. To evaluate thrombin generation, the lag time of initiation, endogenous thrombin potential (ETP), and peak and time to peak thrombin concentration were assessed by CAT in platelet poor plasma without corn trypsin inhibitor...
January 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28953448/serological-survey-of-hantavirus-and-flavivirus-among-wild-rodents-in-central-italy
#13
Gian Mario Cosseddu, Giulia Sozio, Fabrizia Valleriani, Annapia Di Gennaro, Ilaria Pascucci, Stefano Gavaudan, Philippe Marianneau, Federica Monaco
Hantaviruses are a group of zoonotic viruses carried by rodents. Puumala virus (PUUV) and Dobrava virus (DOBV) are the causative agents of human hantavirus infections in Europe. Knowledge about hantavirus circulation in Italy is very scarce. West Nile virus (WNV) and Usutu virus (USUV) are emerging neuropathogenic flaviviruses, both endemic in most part of the Italian territories. To monitor the circulation of PUUV, DOBV, WNV, and USUV in natural environment in central Italy, we carried out serological surveillance in wild rodents...
November 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28953102/emergency-department-utilization-by-native-american-children
#14
Heather G Zook, Anupam B Kharbanda, Susan E Puumala, Katherine A Burgess, Wyatt Pickner, Nathaniel R Payne
OBJECTIVES: The aims of this study were to determine differences in emergency department (ED) use by Native American (NA) children in rural and urban settings and identify factors associated with frequent ED visits. METHODS: This cross-sectional, cohort study examined visits to 6 EDs: 2 rural, 2 midsize urban, and 2 large urban EDs from June 2011 to May 2012. Univariate and multiple regression analyses were conducted. Frequent ED visitors had more than 4 visits in the study period...
September 25, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28948811/-hantavirus-causing-fatal-haemorrhagic-fever-in-the-czech-republic
#15
H Zelená, M Rumlerová, K Kodras, P Beroušková, J Mrázek, J Smetana
Hantaviruses are RNA viruses of the family Bunyaviridae. Their hosts are mammals of the orders rodents (voles, rats, mice), insectivores (shrews, moles), and chiroptera (bats). Hantaviruses are present in many areas of Europe, the Americas, Asia, and Africa. In the Czech Republic, the occurrence of five species of hantaviruses has been reported (Dobrava/Belgrade, Puumala, Tula, Seewis, and Asikkala), with the first three of them causing human diseases. Although the course of hantavirus infections can be very serious, there is a low awareness of these diseases, even among health professionals, and hantavirus is often not considered in the diagnosis...
2017: Epidemiologie, Mikrobiologie, Imunologie
https://www.readbyqxmd.com/read/28943870/gastrointestinal-tract-as-entry-route-for-hantavirus-infection
#16
Peter T Witkowski, Casey C Perley, Rebecca L Brocato, Jay W Hooper, Christian Jürgensen, Jörg-Dieter Schulzke, Detlev H Krüger, Roland Bücker
Background: Hantaviruses are zoonotic agents that cause hemorrhagic fevers and are thought to be transmitted to humans by exposure to aerosolized excreta of infected rodents. Puumala virus (PUUV) is the predominant endemic hantavirus in Europe. A large proportion of PUUV-infected patients suffer from gastrointestinal symptoms of unclear origin. In this study we demonstrate that PUUV infection can occur via the alimentary tract. Methods: We investigated susceptibility of the human small intestinal epithelium for PUUV infection and analyzed the resistance of virions to gastric juice...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28931451/bank-vole-immunoheterogeneity-may-limit-nephropatia-epidemica-emergence-in-a-french-non-endemic-region
#17
A Dubois, G Castel, S Murri, C Pulido, J-B Pons, L Benoit, A Loiseau, L Lakhdar, M Galan, P Marianneau, N Charbonnel
Ecoevolutionary processes affecting hosts, vectors and pathogens are important drivers of zoonotic disease emergence. In this study, we focused on nephropathia epidemica (NE), which is caused by Puumala hantavirus (PUUV) whose natural reservoir is the bank vole, Myodes glareolus. We questioned the possibility of NE emergence in a French region that is considered to be NE-free but that is adjacent to a NE-endemic region. We first confirmed the epidemiology of these two regions and we demonstrated the absence of spatial barriers that could have limited dispersal, and consequently, the spread of PUUV into the NE-free region...
September 21, 2017: Parasitology
https://www.readbyqxmd.com/read/28926508/racial-ethnic-variation-in-emergency-department-care-for-children-with-asthma
#18
Heather G Zook, Nathaniel R Payne, Susan E Puumala, Katherine M Ziegler, Anupam B Kharbanda
OBJECTIVE: To assess the variation between racial/ethnic groups in emergency department (ED) treatment of asthma for pediatric patients. METHODS: This study was a cross-sectional analysis of pediatric (2-18 years) asthma visits among 6 EDs in the Upper Midwest between June 2011 and May 2012. We used mixed-effects logistic regression to assess the odds of receiving steroids, radiology tests, and returning to the ED within 30 days. We conducted a subanalysis of asthma visits where patients received at least 1 albuterol treatment in the ED...
September 18, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28835498/structural-transitions-of-the-conserved-and-metastable-hantaviral-glycoprotein-envelope
#19
Ilona Rissanen, Robert Stass, Antra Zeltina, Sai Li, Jussi Hepojoki, Karl Harlos, Robert J C Gilbert, Juha T Huiskonen, Thomas A Bowden
Hantaviruses are zoonotic pathogens that cause severe hemorrhagic fever and pulmonary syndrome. The outer membrane of the hantavirus envelope displays a lattice of two glycoproteins, Gn and Gc, which orchestrate host cell recognition and entry. Here, we describe the crystal structure of the Gn glycoprotein ectodomain from the Asiatic Hantaan virus (HTNV), the most prevalent pathogenic hantavirus. Structural overlay analysis reveals that the HTNV Gn fold is highly similar to the Gn of Puumala virus (PUUV), a genetically and geographically distinct and less pathogenic hantavirus found predominantly in northeastern Europe, confirming that the hantaviral Gn fold is architecturally conserved across hantavirus clades...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28815001/serogrouping-and-seroepidemiology-of-north-european-hantaviruses-using-a-novel-broadly-targeted-synthetic-nucleoprotein-antigen-array
#20
Bengt Rönnberg, Olli Vapalahti, Marco Goeijenbier, Chantal Reusken, Åke Gustafsson, Jonas Blomberg, Åke Lundkvist
Introduction: Hantaviruses are globally distributed zoonotic pathogens. Great diversity and high antigenic cross-reactivity makes diagnosis by traditional methods cumbersome. Materials and methods: 'Megapeptides', 119-120-mers from the amino terminus of the nucleoprotein of 16 hantaviruses, representing the four major branches of the hantavirus phylogenetic tree, were utilized in a novel IgG-based hantavirus suspension multiplex immunoassay (HSMIA) for detection of past hantavirus infections in 155 North European human samples...
2017: Infection Ecology & Epidemiology
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