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https://www.readbyqxmd.com/read/28093611/a-highly-divergent-puumala-virus-lineage-in-southern-poland
#1
Ulrike M Rosenfeld, Stephan Drewes, Hanan Sheikh Ali, Edyta T Sadowska, Magdalena Mikowska, Gerald Heckel, Paweł Koteja, Rainer G Ulrich
Puumala virus (PUUV) represents one of the most important hantaviruses in Central Europe. Phylogenetic analyses of PUUV strains indicate a strong genetic structuring of this hantavirus. Recently, PUUV sequences were identified in the natural reservoir, the bank vole (Myodes glareolus), collected in the northern part of Poland. The objective of this study was to evaluate the presence of PUUV in bank voles from southern Poland. A total of 72 bank voles were trapped in 2009 at six sites in this part of Poland...
January 16, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28057727/indoleamine-2-3-dioxygenase-activity-is-associated-with-regulatory-t-cell-response-in-acute-puumala-hantavirus-infection
#2
Tuisku-Tuulia Koivula, Anni Tuulasvaara, Iivo Hetemäki, Mikko Hurme, Satu Mäkelä, Jukka Mustonen, Antti Vaheri, T Petteri Arstila
High indoleamine 2,3-dioxygenase (IDO) activity is associated with clinically severe acute infection caused by Puumala hantavirus. The immunoregulatory effects of IDO can be mediated either through metabolic control of effector T cells, caused by depletion of the essential amino acid tryptophan, or intercellular signaling and activation of regulatory T cell responses. Here we have studied 24 patients with acute PUUV infection to distinguish between these possibilities. Maximum IDO activity showed a significant positive correlation with FOXP3 expression levels in regulatory T cells, a quantitative surrogate marker for suppressive capability...
January 5, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28049381/kidney-disease-in-puumala-hantavirus-infection
#3
Jukka Mustonen, Tuula Outinen, Outi Laine, Ilkka Pörsti, Antti Vaheri, Satu Mäkelä
Acute kidney injury (AKI) remains a predominant clinical expression of nephropathia epidemica (NE). Its pathogenesis is not yet fully understood. Here, we describe the tissue injury comprehensively and present new data aimed to characterize the injury and explain its pathophysiology. When compared to tubulointerstitial nephritis of a wide variety of other aetiologies, a high degree of proteinuria is a distinguished trait of NE, a finding that is also helpful in the clinical suspicion of the disease. Recently, novel biomarkers for the prediction of severe AKI, including neutrophil gelatinase-associated lipocalin (NGAL), have been identified and ultrastructural tissue changes have been more accurately described...
January 3, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28033261/elevated-thrombopoietin-and-platelet-indices-confirm-active-thrombopoiesis-but-fail-to-predict-clinical-severity-of-puumala-hantavirus-infection
#4
Outi Laine, Lotta Joutsi-Korhonen, Riitta Lassila, Heini Huhtala, Antti Vaheri, Satu Mäkelä, Jukka Mustonen
We evaluated the mechanisms of thrombocytopenia and procoagulant changes in relation with clinical variables in a cohort of patients with acute hantavirus disease.Blood samples of 33 prospectively recruited, consecutive, hospitalized patients with acute Puumala virus-induced hemorrhagic fever with renal syndrome (HFRS) were collected acutely and at the recovery visit (control). Serum thrombopoietin (TPO) and activity of plasma microparticles (MPs) from various cell sources were measured with enzyme-linked immunosorbent assay-based methods...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27983499/host-associated-absence-of-human-puumala-virus-infections-in-northern-and-eastern-germany
#5
Stephan Drewes, Hanan Sheikh Ali, Moritz Saxenhofer, Ulrike M Rosenfeld, Florian Binder, Fabian Cuypers, Mathias Schlegel, Susanne Röhrs, Gerald Heckel, Rainer G Ulrich
Human hantavirus disease cases, caused by Puumala virus (PUUV), are mainly recorded in western and southern areas of Germany. This bank vole reservoir survey confirmed PUUV presence in these regions but its absence in northern and eastern regions. PUUV occurrence is associated with the presence of the Western bank vole phylogroup.
January 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27956196/microevolution-of-bank-voles-myodes-glareolus-at-neutral-and-immune-related-genes-during-multiannual-dynamic-cycles-consequences-for-puumala-hantavirus-epidemiology
#6
Adelaïde Dubois, Maxime Galan, Jean-François Cosson, Bertrand Gauffre, Heikki Henttonen, Jukka Niemimaa, Maria Razzauti, Liina Voutilainen, Renaud Vitalis, Emmanuel Guivier, Nathalie Charbonnel
Understanding how host dynamics, including variations of population size and dispersal, may affect the epidemiology of infectious diseases through ecological and evolutionary processes is an active research area. Here we focus on a bank vole (Myodes glareolus) metapopulation surveyed in Finland between 2005 and 2009. Bank vole is the reservoir of Puumala hantavirus (PUUV), the agent of nephropathia epidemica (NE, a mild form of hemorrhagic fever with renal symptom) in humans. M.glareolus populations experience multiannual density fluctuations that may influence the level of genetic diversity maintained in bank voles, PUUV prevalence and NE occurrence...
December 9, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27918151/reservoir-driven-heterogeneous-distribution-of-recorded-human-puumala-virus-cases-in-south-west-germany
#7
S Drewes, H Turni, U M Rosenfeld, A Obiegala, P Straková, C Imholt, E Glatthaar, K Dressel, M Pfeffer, J Jacob, C Wagner-Wiening, R G Ulrich
Endemic regions for Puumala virus (PUUV) are located in the most affected federal state Baden-Wuerttemberg, South-West Germany, where high numbers of notified human hantavirus disease cases have been occurring for a long time. The distribution of human cases in Baden-Wuerttemberg is, however, heterogeneous, with a high number of cases recorded during 2012 in four districts (H districts) but a low number or even no cases recorded in four other districts (L districts). Bank vole monitoring during 2012, following a beech (Fagus sylvatica) mast year, resulted in the trapping of 499 bank voles, the host of PUUV...
December 5, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27857837/autoimmune-polyendocrinopathy-and-hypophysitis-after-puumala-hantavirus-infection
#8
Marlene Tarvainen, Satu Mäkelä, Jukka Mustonen, Pia Jaatinen
: Puumala hantavirus (PUUV) infection causes nephropathia epidemica (NE), a relatively mild form of haemorrhagic fever with renal syndrome (HFRS). Hypophyseal haemorrhage and hypopituitarism have been described in case reports on patients with acute NE. Chronic hypopituitarism diagnosed months or years after the acute illness has also been reported, without any signs of a haemorrhagic aetiology. The mechanisms leading to the late-onset hormonal defects remain unknown. Here, we present a case of NE-associated autoimmune polyendocrinopathy and hypopituitarism presumably due to autoimmune hypophysitis...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27842513/clinical-characterization-of-two-severe-cases-of-hemorrhagic-fever-with-renal-syndrome-hfrs-caused-by-hantaviruses-puumala-and-dobrava-belgrade-genotype-sochi
#9
Ellen Krautkrämer, Christian Nusshag, Alexandra Baumann, Julia Schäfer, Jörg Hofmann, Paul Schnitzler, Boris Klempa, Peter T Witkowski, Detlev H Krüger, Martin Zeier
BACKGROUND: Hantavirus disease belongs to the emerging infections. The clinical picture and severity of infections differ between hantavirus species and may even vary between hantavirus genotypes. The mechanisms that lead to the broad variance of severity in infected patients are not completely understood. Host- and virus-specific factors are considered. CASE PRESENTATION: We analyzed severe cases of hantavirus disease in two young women. The first case was caused by Puumala virus (PUUV) infection in Germany; the second case describes the infection with Dobrava-Belgrade virus (DOBV) in Russia...
November 14, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27806736/validation-of-the-puumala-virus-rapid-field-test-for-bank-voles-in-germany
#10
D Reil, C Imholt, U M Rosenfeld, S Drewes, S Fischer, E Heuser, R Petraityte-Burneikiene, R G Ulrich, J Jacob
Puumala virus (PUUV) causes many human infections in large parts of Europe and can lead to mild to moderate disease. The bank vole (Myodes glareolus) is the only reservoir of PUUV in Central Europe. A commercial PUUV rapid field test for rodents was validated for bank-vole blood samples collected in two PUUV-endemic regions in Germany (North Rhine-Westphalia and Baden-Württemberg). A comparison of the results of the rapid field test and standard ELISAs indicated a test efficacy of 93-95%, largely independent of the origin of the antigens used in the ELISA...
November 3, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27783673/crystal-structure-of-glycoprotein-c-from-a-hantavirus-in-the-post-fusion-conformation
#11
Shmuel Willensky, Hagit Bar-Rogovsky, Eduardo A Bignon, Nicole D Tischler, Yorgo Modis, Moshe Dessau
Hantaviruses are important emerging human pathogens and are the causative agents of serious diseases in humans with high mortality rates. Like other members in the Bunyaviridae family their M segment encodes two glycoproteins, GN and GC, which are responsible for the early events of infection. Hantaviruses deliver their tripartite genome into the cytoplasm by fusion of the viral and endosomal membranes in response to the reduced pH of the endosome. Unlike phleboviruses (e.g. Rift valley fever virus), that have an icosahedral glycoprotein envelope, hantaviruses display a pleomorphic virion morphology as GN and GC assemble into spikes with apparent four-fold symmetry organized in a grid-like pattern on the viral membrane...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27737653/human-puumala-hantavirus-infection-in-northern-sweden-increased-seroprevalence-and-association-to-risk-and-health-factors
#12
Kristina Bergstedt Oscarsson, Alette Brorstad, Maria Baudin, Anne Lindberg, Annika Forssén, Magnus Evander, Marie Eriksson, Clas Ahlm
BACKGROUND: The rodent borne Puumala hantavirus (PUUV) causes haemorrhagic fever with renal syndrome in central and northern Europe. The number of cases has increased and northern Sweden has experienced large outbreaks in 1998 and 2006-2007 which raised questions regarding the level of immunity in the human population. METHODS: A randomly selected population aged between 25 and 74 years from northern Sweden were invited during 2009 to participate in a WHO project for monitoring of trends and determinants in cardiovascular disease...
October 13, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27721109/lymphocytic-choriomeningitis-ljungan-and-orthopoxvirus-seroconversions-in-patients-hospitalized-due-to-acute-puumala-hantavirus-infection
#13
Cristina Fevola, Kristian M Forbes, Satu Mäkelä, Niina Putkuri, Heidi C Hauffe, Hannimari Kallio-Kokko, Jukka Mustonen, Anne J Jääskeläinen, Antti Vaheri
BACKGROUND: The emergence and re-emergence of zoonotic and vector-borne diseases are increasing in Europe. Prominent rodent-borne zoonotic viruses include Puumala hantavirus (PUUV; the causative agent of nephropathia epidemica, NE), lymphocytic choriomeningitis virus (LCMV), and orthopoxviruses (OPV). In addition, Ljungan virus (LV) is considered a potentially zoonotic virus. OBJECTIVE: The aim of this study was to compare clinical picture between acute PUUV patients with and without additional rodent-borne viral infections, to investigate if concurrent infections influence disease severity...
November 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27721108/hantavirus-cardiopulmonary-syndrome-due-to-puumala-virus-in-germany
#14
Patrick Vollmar, Matthias Lubnow, Michaela Simon, Thomas Müller, Tobias Bergler, Philipp Alois, Bryan R Thoma, Sandra Essbauer
In Germany Puumala virus (PUUV), known to cause mild forms of hemorrhagic fever with renal syndrome (HFRS), is the predominating endemic hantavirus. We herein describe an unusually severe case of a PUUV infection that occurred in summer 2015 in South Eastern Germany in a region known to be endemic for PUUV since over ten years. A 54-year-old female gardener was admitted to hospital with fever, cough and dyspnea. Within 48hours the patient developed a rapid progressive adult respiratory distress syndrome (ARDS) with circulatory failure and required ECMO (extracorporeal membrane oxygenation) treatment...
November 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27536897/epidemiology-of-substance-exposed-pregnancies-at-one-great-lakes-hospital-that-serves-a-large-number-of-american-indians
#15
Jessica D Hanson, Jamie L Jensen, Kelly Campbell, Kaushal Raj Chaudhary, Susan E Puumala
OBJECTIVE: The purpose of this research was to determine the prevalence of substance-exposed pregnancies at a hospital in the Great Lakes region of the U.S. METHOD: Data were collected via retrospective chart abstractions of patients who were seen for delivery at one Great Lakes region hospital during a 1-year period who were given at least one of the International Classification of Diseases codes related to substance use. RESULTS: A total of 342 medical records were included in the analysis, and, while much race/ethnicity data were missing, a large percentage of those in our analysis identified as American Indian...
2016: American Indian and Alaska Native Mental Health Research: the Journal of the National Center
https://www.readbyqxmd.com/read/27499001/declining-ecosystem-health-and-the-dilution-effect
#16
Hussein Khalil, Frauke Ecke, Magnus Evander, Magnus Magnusson, Birger Hörnfeldt
The "dilution effect" implies that where species vary in susceptibility to infection by a pathogen, higher diversity often leads to lower infection prevalence in hosts. For directly transmitted pathogens, non-host species may "dilute" infection directly (1) and indirectly (2). Competitors and predators may (1) alter host behavior to reduce pathogen transmission or (2) reduce host density. In a well-studied system, we tested the dilution of the zoonotic Puumala hantavirus (PUUV) in bank voles (Myodes glareolus) by two competitors and a predator...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27414047/inhibition-of-the-hantavirus-fusion-process-by-predicted-domain-iii-and-stem-peptides-from-glycoprotein-gc
#17
Gonzalo P Barriga, Fernando Villalón-Letelier, Chantal L Márquez, Eduardo A Bignon, Rodrigo Acuña, Breyan H Ross, Octavio Monasterio, Gonzalo A Mardones, Simon E Vidal, Nicole D Tischler
Hantaviruses can cause hantavirus pulmonary syndrome or hemorrhagic fever with renal syndrome in humans. To enter cells, hantaviruses fuse their envelope membrane with host cell membranes. Previously, we have shown that the Gc envelope glycoprotein is the viral fusion protein sharing characteristics with class II fusion proteins. The ectodomain of class II fusion proteins is composed of three domains connected by a stem region to a transmembrane anchor in the viral envelope. These fusion proteins can be inhibited through exogenous fusion protein fragments spanning domain III (DIII) and the stem region...
July 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27388481/smoking-is-a-risk-factor-for-severe-acute-kidney-injury-in-hantavirus-induced-nephropathia-epidemica
#18
Daniel Kitterer, Stephan Segerer, Juergen Dippon, M Dominik Alscher, Niko Braun, Joerg Latus
BACKGROUND/AIMS: Hantaviruses are zoonotic pathogens causing emerging diseases worldwide. Patients typically present with fever, acute kidney injury (AKI) and thrombocytopenia. Puumala virus (PUUV) that causes nephropathia epidemica (NE) is common in Germany. Recently, a study from Finland revealed an association between nicotine consumption and the severity of AKI in NE. Differences between individuals in Finland and Germany might modulate the effect; therefore, the aim of our study was to prove that smoking is a risk factor for a severe course of NE in Germany...
July 8, 2016: Nephron
https://www.readbyqxmd.com/read/27348219/hmgb1-is-a-potential-biomarker-for-severe-viral-hemorrhagic-fevers
#19
Katarina Resman Rus, Luka Fajs, Miša Korva, Tatjana Avšič-Županc
Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are common representatives of viral hemorrhagic fevers still often neglected in some parts of the world. Infection with Dobrava or Puumala virus (HFRS) and Crimean-Congo hemorrhagic fever virus (CCHFV) can result in a mild, nonspecific febrile illness or as a severe disease with hemorrhaging and high fatality rate. An important factor in optimizing survival rate in patients with VHF is instant recognition of the severe form of the disease for which significant biomarkers need to be elucidated...
June 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27299174/thrombocytopenia-associates-with-the-severity-of-inflammation-and-variables-reflecting-capillary-leakage-in-puumala-hantavirus-infection-an-analysis-of-546-finnish-patients
#20
Tuula K Outinen, Outi K Laine, Satu Mäkelä, Ilkka Pörsti, Heini Huhtala, Antti Vaheri, Jukka Mustonen
BACKGROUND: Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS) in humans. Hantavirus infections are characterized by thrombocytopenia. Our objective was to assess the association of thrombocytopenia with disease severity in HFRS induced by Puumala hantavirus (PUUV). METHODS: Altogether 546 patients treated for acute serologically confirmed PUUV infection during 1982-2013 at Tampere University Hospital, Finland, were examined...
September 2016: Infectious Diseases
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