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https://www.readbyqxmd.com/read/27857837/autoimmune-polyendocrinopathy-and-hypophysitis-after-puumala-hantavirus-infection
#1
Marlene Tarvainen, Satu Mäkelä, Jukka Mustonen, Pia Jaatinen
: Puumala hantavirus (PUUV) infection causes nephropathia epidemica (NE), a relatively mild form of haemorrhagic fever with renal syndrome (HFRS). Hypophyseal haemorrhage and hypopituitarism have been described in case reports on patients with acute NE. Chronic hypopituitarism diagnosed months or years after the acute illness has also been reported, without any signs of a haemorrhagic aetiology. The mechanisms leading to the late-onset hormonal defects remain unknown. Here, we present a case of NE-associated autoimmune polyendocrinopathy and hypopituitarism presumably due to autoimmune hypophysitis...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27842513/clinical-characterization-of-two-severe-cases-of-hemorrhagic-fever-with-renal-syndrome-hfrs-caused-by-hantaviruses-puumala-and-dobrava-belgrade-genotype-sochi
#2
Ellen Krautkrämer, Christian Nusshag, Alexandra Baumann, Julia Schäfer, Jörg Hofmann, Paul Schnitzler, Boris Klempa, Peter T Witkowski, Detlev H Krüger, Martin Zeier
BACKGROUND: Hantavirus disease belongs to the emerging infections. The clinical picture and severity of infections differ between hantavirus species and may even vary between hantavirus genotypes. The mechanisms that lead to the broad variance of severity in infected patients are not completely understood. Host- and virus-specific factors are considered. CASE PRESENTATION: We analyzed severe cases of hantavirus disease in two young women. The first case was caused by Puumala virus (PUUV) infection in Germany; the second case describes the infection with Dobrava-Belgrade virus (DOBV) in Russia...
November 14, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27806736/validation-of-the-puumala-virus-rapid-field-test-for-bank-voles-in-germany
#3
D Reil, C Imholt, U M Rosenfeld, S Drewes, S Fischer, E Heuser, R Petraityte-Burneikiene, R G Ulrich, J Jacob
Puumala virus (PUUV) causes many human infections in large parts of Europe and can lead to mild to moderate disease. The bank vole (Myodes glareolus) is the only reservoir of PUUV in Central Europe. A commercial PUUV rapid field test for rodents was validated for bank-vole blood samples collected in two PUUV-endemic regions in Germany (North Rhine-Westphalia and Baden-Württemberg). A comparison of the results of the rapid field test and standard ELISAs indicated a test efficacy of 93-95%, largely independent of the origin of the antigens used in the ELISA...
November 3, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27783673/crystal-structure-of-glycoprotein-c-from-a-hantavirus-in-the-post-fusion-conformation
#4
Shmuel Willensky, Hagit Bar-Rogovsky, Eduardo A Bignon, Nicole D Tischler, Yorgo Modis, Moshe Dessau
Hantaviruses are important emerging human pathogens and are the causative agents of serious diseases in humans with high mortality rates. Like other members in the Bunyaviridae family their M segment encodes two glycoproteins, GN and GC, which are responsible for the early events of infection. Hantaviruses deliver their tripartite genome into the cytoplasm by fusion of the viral and endosomal membranes in response to the reduced pH of the endosome. Unlike phleboviruses (e.g. Rift valley fever virus), that have an icosahedral glycoprotein envelope, hantaviruses display a pleomorphic virion morphology as GN and GC assemble into spikes with apparent four-fold symmetry organized in a grid-like pattern on the viral membrane...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27737653/human-puumala-hantavirus-infection-in-northern-sweden-increased-seroprevalence-and-association-to-risk-and-health-factors
#5
Kristina Bergstedt Oscarsson, Alette Brorstad, Maria Baudin, Anne Lindberg, Annika Forssén, Magnus Evander, Marie Eriksson, Clas Ahlm
BACKGROUND: The rodent borne Puumala hantavirus (PUUV) causes haemorrhagic fever with renal syndrome in central and northern Europe. The number of cases has increased and northern Sweden has experienced large outbreaks in 1998 and 2006-2007 which raised questions regarding the level of immunity in the human population. METHODS: A randomly selected population aged between 25 and 74 years from northern Sweden were invited during 2009 to participate in a WHO project for monitoring of trends and determinants in cardiovascular disease...
October 13, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27721109/lymphocytic-choriomeningitis-ljungan-and-orthopoxvirus-seroconversions-in-patients-hospitalized-due-to-acute-puumala-hantavirus-infection
#6
Cristina Fevola, Kristian M Forbes, Satu Mäkelä, Niina Putkuri, Heidi C Hauffe, Hannimari Kallio-Kokko, Jukka Mustonen, Anne J Jääskeläinen, Antti Vaheri
BACKGROUND: The emergence and re-emergence of zoonotic and vector-borne diseases are increasing in Europe. Prominent rodent-borne zoonotic viruses include Puumala hantavirus (PUUV; the causative agent of nephropathia epidemica, NE), lymphocytic choriomeningitis virus (LCMV), and orthopoxviruses (OPV). In addition, Ljungan virus (LV) is considered a potentially zoonotic virus. OBJECTIVE: The aim of this study was to compare clinical picture between acute PUUV patients with and without additional rodent-borne viral infections, to investigate if concurrent infections influence disease severity...
October 4, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27721108/hantavirus-cardiopulmonary-syndrome-due-to-puumala-virus-in-germany
#7
Patrick Vollmar, Matthias Lubnow, Michaela Simon, Thomas Müller, Tobias Bergler, Philipp Alois, Bryan R Thoma, Sandra Essbauer
In Germany Puumala virus (PUUV), known to cause mild forms of hemorrhagic fever with renal syndrome (HFRS), is the predominating endemic hantavirus. We herein describe an unusually severe case of a PUUV infection that occurred in summer 2015 in South Eastern Germany in a region known to be endemic for PUUV since over ten years. A 54-year-old female gardener was admitted to hospital with fever, cough and dyspnea. Within 48hours the patient developed a rapid progressive adult respiratory distress syndrome (ARDS) with circulatory failure and required ECMO (extracorporeal membrane oxygenation) treatment...
October 4, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27536897/epidemiology-of-substance-exposed-pregnancies-at-one-great-lakes-hospital-that-serves-a-large-number-of-american-indians
#8
Jessica D Hanson, Jamie L Jensen, Kelly Campbell, Kaushal Raj Chaudhary, Susan E Puumala
OBJECTIVE: The purpose of this research was to determine the prevalence of substance-exposed pregnancies at a hospital in the Great Lakes region of the U.S. METHOD: Data were collected via retrospective chart abstractions of patients who were seen for delivery at one Great Lakes region hospital during a 1-year period who were given at least one of the International Classification of Diseases codes related to substance use. RESULTS: A total of 342 medical records were included in the analysis, and, while much race/ethnicity data were missing, a large percentage of those in our analysis identified as American Indian...
2016: American Indian and Alaska Native Mental Health Research: the Journal of the National Center
https://www.readbyqxmd.com/read/27499001/declining-ecosystem-health-and-the-dilution-effect
#9
Hussein Khalil, Frauke Ecke, Magnus Evander, Magnus Magnusson, Birger Hörnfeldt
The "dilution effect" implies that where species vary in susceptibility to infection by a pathogen, higher diversity often leads to lower infection prevalence in hosts. For directly transmitted pathogens, non-host species may "dilute" infection directly (1) and indirectly (2). Competitors and predators may (1) alter host behavior to reduce pathogen transmission or (2) reduce host density. In a well-studied system, we tested the dilution of the zoonotic Puumala hantavirus (PUUV) in bank voles (Myodes glareolus) by two competitors and a predator...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27414047/inhibition-of-the-hantavirus-fusion-process-by-predicted-domain-iii-and-stem-peptides-from-glycoprotein-gc
#10
Gonzalo P Barriga, Fernando Villalón-Letelier, Chantal L Márquez, Eduardo A Bignon, Rodrigo Acuña, Breyan H Ross, Octavio Monasterio, Gonzalo A Mardones, Simon E Vidal, Nicole D Tischler
Hantaviruses can cause hantavirus pulmonary syndrome or hemorrhagic fever with renal syndrome in humans. To enter cells, hantaviruses fuse their envelope membrane with host cell membranes. Previously, we have shown that the Gc envelope glycoprotein is the viral fusion protein sharing characteristics with class II fusion proteins. The ectodomain of class II fusion proteins is composed of three domains connected by a stem region to a transmembrane anchor in the viral envelope. These fusion proteins can be inhibited through exogenous fusion protein fragments spanning domain III (DIII) and the stem region...
July 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27388481/smoking-is-a-risk-factor-for-severe-acute-kidney-injury-in-hantavirus-induced-nephropathia-epidemica
#11
Daniel Kitterer, Stephan Segerer, Juergen Dippon, M Dominik Alscher, Niko Braun, Joerg Latus
BACKGROUND/AIMS: Hantaviruses are zoonotic pathogens causing emerging diseases worldwide. Patients typically present with fever, acute kidney injury (AKI) and thrombocytopenia. Puumala virus (PUUV) that causes nephropathia epidemica (NE) is common in Germany. Recently, a study from Finland revealed an association between nicotine consumption and the severity of AKI in NE. Differences between individuals in Finland and Germany might modulate the effect; therefore, the aim of our study was to prove that smoking is a risk factor for a severe course of NE in Germany...
July 8, 2016: Nephron
https://www.readbyqxmd.com/read/27348219/hmgb1-is-a-potential-biomarker-for-severe-viral-hemorrhagic-fevers
#12
Katarina Resman Rus, Luka Fajs, Miša Korva, Tatjana Avšič-Županc
Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are common representatives of viral hemorrhagic fevers still often neglected in some parts of the world. Infection with Dobrava or Puumala virus (HFRS) and Crimean-Congo hemorrhagic fever virus (CCHFV) can result in a mild, nonspecific febrile illness or as a severe disease with hemorrhaging and high fatality rate. An important factor in optimizing survival rate in patients with VHF is instant recognition of the severe form of the disease for which significant biomarkers need to be elucidated...
June 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27299174/thrombocytopenia-associates-with-the-severity-of-inflammation-and-variables-reflecting-capillary-leakage-in-puumala-hantavirus-infection-an-analysis-of-546-finnish-patients
#13
Tuula K Outinen, Outi K Laine, Satu Mäkelä, Ilkka Pörsti, Heini Huhtala, Antti Vaheri, Jukka Mustonen
BACKGROUND: Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS) in humans. Hantavirus infections are characterized by thrombocytopenia. Our objective was to assess the association of thrombocytopenia with disease severity in HFRS induced by Puumala hantavirus (PUUV). METHODS: Altogether 546 patients treated for acute serologically confirmed PUUV infection during 1982-2013 at Tampere University Hospital, Finland, were examined...
September 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27296590/electrocardiographic-abnormalities-and-relative-bradycardia-in-patients-with-hantavirus-induced-nephropathia-epidemica
#14
Daniel Kitterer, Simon Greulich, Stefan Grün, Stephan Segerer, Jukka Mustonen, M Dominik Alscher, Niko Braun, Joerg Latus
BACKGROUND: Nephropathia epidemica (NE), caused by Puumala virus (PUUV), is characterized by acute kidney injury (AKI) and thrombocytopenia. Cardiac involvement with electrocardiographic (ECG) abnormalities has been previously reported in NE; however, its prognostic value is unknown. Relative bradycardia is an important clinical sign in various infectious diseases, and previous smaller studies have described pulse-temperature deficit in patients with PUUV infection. METHODS: We performed a cross-sectional survey of 471 adult patients with serologically confirmed NE...
September 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27283793/islet-autoantibodies-present-in-association-with-ljungan-virus-infection-in-bank-voles-myodes-glareolus-in-northern-sweden
#15
Anna Warvsten, Martin Björnfors, Michael Arvidsson, Fariba Vaziri-Sani, Ida Jönsson, Gert E Olsson, Clas Ahlm, Helena Elding Larsson, Åke Lernmark, Anna-Lena Nilsson
: Bank voles are known reservoirs for Puumala hantavirus and probably also for Ljungan virus (LV), a suggested candidate parechovirus in type 1 diabetes etiology and pathogenesis. The aim of this study was to determine whether wild bank voles had been exposed to LV and if exposure associated to autoantibodies against insulin (IAA), glutamic acid decarboxylase 65 (GADA) or islet autoantigen-2 (IA-2A). Serum samples from bank voles (Myodes glareolus) captured in early summer or early winter of 1997 and 1998, respectively, were analyzed in radiobinding assays for antibodies against Ljungan virus (LVA) and Puumala virus (PUUVA) as well as for IAA, GADA and IA-2A...
June 10, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27258208/hantavirus-in-new-geographic-regions-sweden
#16
Mare Lõhmus, Jenny Verner-Carlsson, Oliva Borg, Ann Albihn, Åke Lundkvist
In Sweden, human cases of Puumala hantavirus (PUUV) infections are reported from the northern endemic regions. We found hantavirus-specific antibodies in yellow-necked mice (Apodemus flavicollis) trapped in human dwellings in the surroundings of the cities of Uppsala and Stockholm, which are situated far south from the traditional endemic areas of PUUV. Because the yellow-necked mouse is the most common rodent in human dwellings, hantaviruses in this rodent species may be important for the public health.
2016: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/27175497/-optimization-of-elisa-and-immunoblot-methods-for-the-detection-of-igg-antibodies-against-old-world-hantaviruses-in-wild-rodents
#17
Ceylan Polat, Ahmet Karataş, Mustafa Sözen, Ferhat Matur, Hakan Abacıoğlu, Mehmet Ali Öktem
Hantaviruses infect humans via inhalation of viral particles in infected rodents' secretions such as saliva, urine and faeces or via direct contact with infected rodents. The rodent species that are known as the carriers of Dobrava (DOBV), Puumala (PUUV), Saaremaa (SAAV), Tula (TULV) and Seoul (SEOV) viruses are found in our country. The presence of specific antibodies against hantaviruses have been demonstrated in rodents collected from Black Sea and Aegean Regions of Turkey in 2004 for the first time. The first hantavirus-related hemorrhagic fever with renal syndrome (HFRS) cases were reported in Black Sea region in 2009...
April 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/27131404/emergency-department-utilization-for-mental-health-in-american-indian%C3%A2-children
#18
Wyatt J Pickner, Susan E Puumala, Kaushal R Chaudhary, Katherine M Burgess, Nathaniel R Payne, Anupam B Kharbanda
OBJECTIVES: To examine emergency department (ED) visits for mental health concerns by American Indian children in a multicenter cohort. To analyze demographic and clinical factors, the types of mental health concerns, and repeat mental health visits. STUDY DESIGN: Cross-sectional study of children 5-18 years old who visited 1 of 6 EDs in the Upper Midwest from June 2011 to May 2012 and self-identified as white or American Indian. Mental health visits were identified by primary diagnosis and reasons for visit and were categorized into diagnostic groups...
July 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27117403/a-molecular-level-account-of-the-antigenic-hantaviral-surface
#19
Sai Li, Ilona Rissanen, Antra Zeltina, Jussi Hepojoki, Jayna Raghwani, Karl Harlos, Oliver G Pybus, Juha T Huiskonen, Thomas A Bowden
Hantaviruses, a geographically diverse group of zoonotic pathogens, initiate cell infection through the concerted action of Gn and Gc viral surface glycoproteins. Here, we describe the high-resolution crystal structure of the antigenic ectodomain of Gn from Puumala hantavirus (PUUV), a causative agent of hemorrhagic fever with renal syndrome. Fitting of PUUV Gn into an electron cryomicroscopy reconstruction of intact Gn-Gc spike complexes from the closely related but non-pathogenic Tula hantavirus localized Gn tetramers to the membrane-distal surface of the virion...
May 3, 2016: Cell Reports
https://www.readbyqxmd.com/read/27113030/regional-differences-in-long-term-cycles-and-seasonality-of-puumala-virus-infections-finland-1995-2014
#20
J Sane, J Ollgren, P Makary, O Vapalahti, M Kuusi, O Lyytikäinen
Puumala hantavirus (PUUV) causes haemorrhagic fever with renal syndrome in humans, an endemic disease in Finland. We aimed to study recent trends in PUUV infections in Finland, to evaluate whether there are regional differences in seasonality and long-term cycles and whether the patterns have changed over time. We analysed serologically confirmed acute PUUV infections reported to the National Infectious Disease Register from 1 April 1995 to 31 March 2014. A total of 30 942 cases of PUUV infections were identified during the study period...
October 2016: Epidemiology and Infection
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