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https://www.readbyqxmd.com/read/29346183/near-infrared-spectroscopy-to-predict-organ-failure-and-outcome-in-sepsis-the-assessing-risk-in-sepsis-using-a-tissue-oxygen-saturation-aristos-study
#1
Stephen P J Macdonald, Frances B Kinnear, Glenn Arendts, Kwok M Ho, Daniel M Fatovich
OBJECTIVES: Sepsis is acute organ dysfunction in the setting of infection. An accurate diagnosis is important to guide treatment and disposition. Tissue oxygen saturation (StO2) can be estimated noninvasively by near-infrared spectroscopy (NIRS), and may be an indicator of microcirculatory dysfunction in early sepsis. We aimed to determine the utility of StO2 for sepsis recognition and outcome prediction among patients presenting to the emergency department (ED) with infection. PATIENTS AND METHODS: A multicentre, prospective, observational cohort study recruited patients who were being admitted to hospital with infection...
January 17, 2018: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/29342457/the-von-hippel-lindau-gene-is-required-to-maintain-renal-proximal-tubule-and-glomerulus-integrity-in-zebrafish-larvae
#2
Ellen van Rooijen, Glenn van de Hoek, Ive Logister, Henry Ajzenberg, Nine V A M Knoers, Freek van Eeden, Emile E Voest, Stefan Schulte-Merker, Rachel H Giles
BACKGROUND: von Hippel-Lindau (VHL) disease is characterized by the development of benign and malignant tumours in many organ systems, including renal cysts and clear cell renal cell carcinoma. It is not completely understood what underlies the development of renal pathology, and the use of murine Vhl models has been challenging due to limitations in disease conservation. We previously described a zebrafish model bearing inactivating mutations in the orthologue of the human VHL gene. METHODS: We used histopathological and functional assays to investigate the pronephric and glomerular developmental defects in vhl mutant zebrafish, supported by human cell culture assays...
January 17, 2018: Nephron
https://www.readbyqxmd.com/read/29339981/using-bilateral-functional-and-anthropometric-tests-to-define-symmetry-in-cross-country-skiers
#3
Glenn Björklund, Marie Alricsson, Ulla Svantesson
The aim of this study was to evaluate the symmetry of anthropometry and muscle function in cross-country skiers and their association to vertical jumping power. Twenty cross-country skiers were recruited (21.7 ± 3.8 yrs, 180.6 ± 7.6 cm, 73.2 ± 7.6 kg). Anthropometric data was obtained using an iDXA scan. VO2max was determined using the diagonal stride technique on a ski treadmill. Bilateral functional tests for the upper and lower body were the handgrip and standing heel-rise tests. Vertical jump height and power were assessed with a counter movement jump...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29338388/novel-fusion-protein-targeting-mitochondrial-dna-improves-pancreatic-islet-functional-potency-and-islet-transplantation-outcomes
#4
Juan S Danobeitia, Peter J Chlebeck, Inna Shokolenko, Xiaobo Ma, Glenn Wilson, Luis A Fernandez
Long-term graft survival is an ongoing challenge in the field of islet transplantation. With the growing demand for transplantable organs, therapies to improve organ quality and reduce the incidence of graft dysfunction are of paramount importance. We evaluated the protective role of a recombinant DNA repair protein targeted to mitochondria (Exscien I-III), as a therapeutic agent using a rodent model of pancreatic islet transplantation. We first investigated the effect of therapy on isolated rat islets cultured with pro-inflammatory cytokines (interleukin-1 β, interferon γ, and tumor necrosis factor α) for 48 h and documented a significant reduction in apoptosis by flow cytometry, improved viability by immunofluorescence, and conserved functional potency in vitro and in vivo in Exscien I-III-treated islets...
November 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29337616/chronologic-analysis-of-gross-and-histologic-lesions-induced-by-field-strains-of-fadv-1-fadv-8b-and-fadv-11-in-six-week-old-chickens
#5
Penelope Steer-Cope, Jeanine Sandy, Denise O'Rourke, Peter Scott, Glenn Browning, Amir Noormohammadi
Inclusion body hepatitis (IBH) is a disease affecting broiler chicken flocks worldwide. Several serotypes of fowl adenovirus (FAdV) have been implicated in disease outbreaks, with and without immunosuppression as a predisposing factor. IBH usually occurs in flocks up to 30 days of age; it is seldom seen in older birds. The objective of this study was to determine whether the pathogenicity for older birds of three FAdV field strains, belonging to serotypes 1, 8b, and 11, in the absence of immunosuppressive factors, was akin to that for younger birds, and to establish an effective and economical disease model for assessing cross-protection between serotypes...
December 2017: Avian Diseases
https://www.readbyqxmd.com/read/29337121/the-society-of-thoracic-surgeons-congenital-heart-surgery-database-2018-update-on-outcomes-and-quality
#6
Jeffrey P Jacobs, John E Mayer, Sara K Pasquali, Kevin D Hill, David M Overman, James D St Louis, S Ram Kumar, Carl L Backer, Charles D Fraser, James S Tweddell, Marshall L Jacobs
The Society of Thoracic Surgeons Congenital Heart Surgery Database is a comprehensive clinical outcomes registry which captures almost all pediatric cardiac surgical operations in the United States. It is the platform for all activities of The Society of Thoracic Surgeons related to the analysis of outcomes and the improvement of quality in this subspecialty. This article summarizes current aggregate national outcomes in congenital and pediatric cardiac surgery and reviews related activities in the areas of quality measurement, performance improvement, and transparency...
January 11, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29336670/does-drug-use-inhibit-crime-deceleration-or-does-crime-inhibit-drug-use-deceleration-a-test-of-the-reciprocal-risk-postulate-of-the-worst-of-both-worlds-hypothesis
#7
Glenn D Walters
BACKGROUND: Prior research has shown that ongoing drug use inhibits the commonly reported maturing out of crime process and that ongoing crime inhibits the commonly reported maturing out of drug use process. OBJECTIVES: To test the predictive efficacy of drug use for crime deceleration and of crime for drug deceleration using a prospective analysis of data on a group of 524 male California Youth Authority parolees to see if both effects exist simultaneously. METHOD: A two-equation regression analysis of Year 3 arrests and illicit drug use was performed, controlling for age, race, marital status, employment status, and number of months free in the community...
January 16, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29336018/the-legacy-of-early-abuse-and-neglect-for-social-and-academic-competence-from-childhood-to-adulthood
#8
K Lee Raby, Glenn I Roisman, Madelyn H Labella, Jodi Martin, R Chris Fraley, Jeffry A Simpson
This study used data from the Minnesota Longitudinal Study of Risk and Adaptation (N = 267) to investigate whether abuse and neglect experiences during the first 5 years of life have fading or enduring consequences for social and academic competence over the next 3 decades of life. Experiencing early abuse and neglect was consistently associated with more interpersonal problems and lower academic achievement from childhood through adulthood (32-34 years). The predictive significance of early abuse and neglect was not attributable to the stability of developmental competence over time, nor to abuse and neglect occurring later in childhood...
January 15, 2018: Child Development
https://www.readbyqxmd.com/read/29335906/the-health-behaviors-of-ethnically-diverse-women-at-increased-risk-of-gestational-diabetes-the-behaviors-affecting-baby-and-you-b-a-b-y-study
#9
Carrie J Nobles, Bess H Marcus, Edward J Stanek, Barry Braun, Brian W Whitcomb, JoAnn E Manson, Glenn Markenson, Lisa Chasan-Taber
Objectives Cigarette smoking, low physical activity, and sedentary behavior are modifiable risk factors for adverse pregnancy outcomes. However, only one study has evaluated predictors of these health risk behaviors among women at high risk for gestational diabetes mellitus (GDM). Therefore, our goal was to examine predictors of smoking, low physical activity, and sedentary behavior during pregnancy in an ethnically diverse high risk cohort. Methods This cross-sectional analysis utilized baseline data from the Behaviors Affecting Baby and You (B...
January 15, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29335572/variation-and-constraints-in-hybrid-genome-formation
#10
Anna Runemark, Cassandra N Trier, Fabrice Eroukhmanoff, Jo S Hermansen, Michael Matschiner, Mark Ravinet, Tore O Elgvin, Glenn-Peter Sætre
Hybridization is an important source of variation; it transfers adaptive genetic variation across species boundaries and generates new species. Yet, the limits to viable hybrid genome formation are poorly understood. Here we investigated to what extent hybrid genomes are free to evolve by sequencing the genomes of four island populations of the homoploid hybrid Italian sparrow Passer italiae. We report that a variety of novel and fully functional hybrid genomic combinations are likely to have arisen independently on Crete, Corsica, Sicily and Malta, with differentiation in candidate genes for beak shape and plumage colour...
January 15, 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29335238/automating-quality-measures-for-heart-failure-using-natural-language-processing-a-descriptive-study-in-the-department-of-veterans-affairs
#11
Jennifer Hornung Garvin, Youngjun Kim, Glenn Temple Gobbel, Michael E Matheny, Andrew Redd, Bruce E Bray, Paul Heidenreich, Dan Bolton, Julia Heavirland, Natalie Kelly, Ruth Reeves, Megha Kalsy, Mary Kane Goldstein, Stephane M Meystre
BACKGROUND: We developed an accurate, stakeholder-informed, automated, natural language processing (NLP) system to measure the quality of heart failure (HF) inpatient care, and explored the potential for adoption of this system within an integrated health care system. OBJECTIVE: To accurately automate a United States Department of Veterans Affairs (VA) quality measure for inpatients with HF. METHODS: We automated the HF quality measure Congestive Heart Failure Inpatient Measure 19 (CHI19) that identifies whether a given patient has left ventricular ejection fraction (LVEF) <40%, and if so, whether an angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker was prescribed at discharge if there were no contraindications...
January 15, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29333880/pharmacogenetic-analysis-of-opioid-dependence-treatment-dose-and-dropout-rate
#12
Richard C Crist, James Li, Glenn A Doyle, Alex Gilbert, Bryan M Dechairo, Wade H Berrettini
BACKGROUND: Currently, no pharmacogenetic tests for selecting an opioid-dependence pharmacotherapy have been approved by the US Food and Drug Administration. OBJECTIVES: Determine the effects of variants in 11 genes on dropout rate and dose in patients receiving methadone or buprenorphine/naloxone (ClinicalTrials.gov Identifier: NCT00315341). METHODS: Variants in six pharmacokinetic genes (CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4) and five pharmacodynamic genes (HTR2A, OPRM1, ADRA2A, COMT, SLC6A4) were genotyped in samples from a 24-week, randomized, open-label trial of methadone and buprenorphine/naloxone for the treatment of opioid dependence (n = 764; 68...
January 15, 2018: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29333363/creating-a-multi-center-rare-disease-consortium-the-consortium-of-eosinophilic-gastrointestinal-disease-researchers-cegir
#13
Katherine Cheng, Sandeep K Gupta, Susanna Kantor, Jonathan T Kuhl, Seema S Aceves, Peter A Bonis, Kelley E Capocelli, Christina Carpenter, Mirna Chehade, Margaret H Collins, Evan S Dellon, Gary W Falk, Rashmi Gopal-Srivastava, Nirmala Gonsalves, Ikuo Hirano, Eileen C King, John Leung, Jeffrey P Krischer, Vincent A Mukkada, Alain Schoepfer, Jonathan M Spergel, Alex Straumann, Guang-Yu Yang, Glenn T Furuta, Marc E Rothenberg
 Eosinophilic gastrointestinal disorders (EGIDs) affect various segments of the gastrointestinal tract. Since these disorders are rare, collaboration is essential to enroll subjects in clinical studies and study the broader population. The Rare Diseases Clinical Research Network (RDCRN), a program of the National Center for Advancing Translational Sciences (NCATS), funded the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) in 2014 to advance the field of EGIDs. CEGIR facilitates collaboration among various centers, subspecialties, patients, professional organizations and patient-advocacy groups and includes 14 clinical sites...
December 18, 2017: Translational Science of Rare Diseases
https://www.readbyqxmd.com/read/29332144/long-acting-%C3%AE-2-agonists-in-asthma-enantioselective-safety-studies-are-needed
#14
Glenn A Jacobson, Sharanne Raidal, Morten Hostrup, Luigino Calzetta, Richard Wood-Baker, Mark O Farber, Clive P Page, E Haydn Walters
Long-acting β2-agonists (LABAs) such as formoterol and salmeterol are used for prolonged bronchodilatation in asthma, usually in combination with inhaled corticosteroids (ICSs). Unexplained paradoxical asthma exacerbations and deaths have been associated with LABAs, particularly when used without ICS. LABAs clearly demonstrate effective bronchodilatation and steroid-sparing activity, but long-term treatment can lead to tolerance of their bronchodilator effects. There are also concerns with regard to the effects of LABAs on bronchial hyperresponsiveness (BHR), where long-term use is associated with increased BHR and loss of bronchoprotection...
January 13, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29331062/benefits-of-increasing-transpiration-efficiency-in-wheat-under-elevated-co2-for-rainfed-regions
#15
Brendan Christy, Sabine Tausz-Posch, Michael Tausz, Richard Richards, Greg Rebetzke, Anthony Condon, Terry Mclean, Glenn Fitzgerald, Maryse Bourgault, Garry O'Leary
Higher transpiration efficiency (TE) has been proposed as a mechanism to increase crop yields in dry environments where water availability usually limits yield. The application of a coupled radiation and transpiration efficiency simulation model shows wheat yield advantage of a high TE cultivar (cv. Drysdale) over its almost identical low TE parent line (Hartog), from about -7 to 558 kg ha-1 (mean 187 kg ha-1 ) over the rainfed cropping region in Australia (221 to 1351 mm annual rainfall), under the present-day climate...
January 13, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29330675/recognizing-conserved-non-canonical-localization-patterns-of-toll-like-receptors-in-tissues-and-across-species
#16
REVIEW
Glenn Hamonic, J Alex Pasternak, Heather L Wilson
Toll-like receptors (TLR) 1, 2, 4, 5 and 6 were originally characterized as exclusively expressed on the cell surface and TLR 3, 7, 8 and 9 were said to be localized to the endosomes. However, continued research in this area shows that TLR localization may be altered across cell-types, and in response to stimulation, age or disease. Mucosal surfaces must remain tolerant to the commensal flora and thus intracellular or basal lateral localization of TLRs at mucosal surfaces may be necessary to prevent induction of an inflammatory response to commensal flora while still allowing the possibility for the receptors to prime an immune response when a pathogen has crossed the epithelial barrier...
January 12, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29330615/the-parameter-identification-problem-for-sir-epidemic-models-identifying-unreported-cases
#17
Pierre Magal, Glenn Webb
A SIR epidemic model is analyzed with respect to identification of its parameters, based upon reported case data from public health sources. The objective of the analysis is to understand the relation of unreported cases to reported cases. In many epidemic diseases the ratio of unreported to reported cases is very high, and of major importance in implementing measures for controlling the epidemic. This ratio can be estimated by the identification of parameters for the model from reported case data. The analysis is applied to three examples: (1) the Hong Kong seasonal influenza epidemic in New York City in 1968-1969, (2) the bubonic plague epidemic in Bombay, India in 1906, and (3) the seasonal influenza epidemic in Puerto Rico in 2016-2017...
January 13, 2018: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/29329499/a-pilot-study-of-the-comparative-efficacy-of-100%C3%A2-hz-magnetic-seizure-therapy-and-electroconvulsive-therapy-in-persistent-depression
#18
Paul B Fitzgerald, Kate E Hoy, David Elliot, Susan McQueen, Lenore E Wambeek, Leo Chen, Anne Maree Clinton, Glenn Downey, Zafiris J Daskalakis
BACKGROUND: Magnetic seizure therapy (MST) is a novel brain stimulation technique that uses a high-powered transcranial magnetic stimulation device to produce therapeutic seizures. Preliminary MST studies have found antidepressant effects in the absence of cognitive side effects but its efficacy compared to electroconvulsive therapy (ECT) remains unclear. The aim of this study was to investigate the therapeutic efficacy and cognitive profile of MST compared to standard right unilateral ECT treatment...
January 12, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29329218/molecular-and-physiological-effects-on-the-small-intestine-of-weaner-pigs-following-feeding-with-deoxynivalenol-contaminated-feed
#19
J Alex Pasternak, Vaishnavi Iyer Aka Aiyer, Glenn Hamonic, A Denise Beaulieu, Daniel A Columbus, Heather L Wilson
We intended to assess how exposure of piglets to deoxynivalenol (DON)-contaminated feed impacted their growth, immune response and gut development. Piglets were fed traditional Phase I, Phase II and Phase III diets with the control group receiving 0.20-0.40 ppm DON (referred to as the Control group) and treatment group receiving much higher level of DON-contaminated wheat (3.30-3.80 ppm; referred to as DON-contaminated group). Feeding a DON-contaminated diet had no impact on average daily feed intake (ADFI) (p < 0...
January 12, 2018: Toxins
https://www.readbyqxmd.com/read/29328676/stabilizing-leaf-and-branch-compost-cutinase-lcc-with-glycosylation-mechanism-and-effect-on-pet-hydrolysis
#20
Abhijit N Shirke, Christine White, Jacob A Englaender, Allison Sophie Zwarycz, Glenn L Butterfoss, Robert J Linhardt, Richard A Gross
Cutinases are polyester hydrolases that show a remarkable capability to hydrolyze polyethylene terephthalate (PET) to its monomeric units. This revelation has stimulated research aimed at developing sustainable and green cutinase-catalyzed PET recycling methods. Leaf and branch compost cutinase (LCC) is particularly suited towards these ends given its relatively high PET hydrolysis activity and thermostability. Any practical enzymatic PET recycling application will require that the protein have kinetic stability at or above the PET glass transition temperature (Tg, i...
January 12, 2018: Biochemistry
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