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https://www.readbyqxmd.com/read/28092725/strontium-ranelate-a-promising-disease-modifying-osteoarthritis-drug
#1
Weiyu Han, Shicai Fan, Xiaochun Bai, Changhai Ding
The articular cartilage and subchondral bone may have potential crosstalk in the development and progression of osteoarthritis (OA). Strontium ranelate (SrR) has the ability to dissociate the bone remodeling process and to change the balance between bone resorption and bone formation. Its effect on subchondral bone makes it a potential disease- modifying osteoarthritis drug (DMOAD) in the treatment of OA. The aim of the current review is to summarize up-to-date pharmacological and clinical data of SrR for OA treatment...
January 16, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28089900/the-rs4238326-polymorphism-in-aldh1a2-gene-potentially-associated-with-non-post-traumatic-knee-osteoarthritis-susceptibility-a-two-stage-population-based-study
#2
Minjie Chu, Xiaoyue Zhu, Chunli Wang, Jiesheng Rong, Yidan Wang, Shengyu Wang, Baifen Xing, Yuchun Tao, Xun Zhuang, Liying Jiang
OBJECTIVE: A recent genome-wide association study reported significant associations of genetic variants within the ALDH1A2 gene with osteoarthritis (OA) of the hand in European populations. However, these findings have not been well generalized to other joints, or to other populations. METHODS: We performed a two-stage population-based case-control study including 196 non-post traumatic knee OA cases and 442 controls in the first stage and independent 143 non-post traumatic knee OA cases and 238 controls in the second stage in a Chinese population by genotyping 8 tagging polymorphisms in ALDH1A2...
January 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28077692/reference-curves-for-the-australian-canadian-hand-osteoarthritis-index-in-the-middle-aged-dutch-population
#3
Féline P B Kroon, Sofia Ramiro, Patrick Royston, Saskia Le Cessie, Frits R Rosendaal, Margreet Kloppenburg
OBJECTIVE: The aim was to establish reference curves of the Australian/Canadian Hand Osteoarthritis Index (AUSCAN), a widely used questionnaire assessing hand complaints. METHODS: Analyses were performed in a population-based sample, The Netherlands Epidemiology of Obesity study (n = 6671, aged 45-65 years). Factors associated with AUSCAN scores were analysed with ordered logistic regression, because AUSCAN data were zero inflated, dividing AUSCAN into three categories (0 vs 1-5 vs >5)...
January 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28070636/extracellular-matrix-loss-in-chondrocytes-after-exposure-to-interleukin-1%C3%AE-in-nadph-oxidase-dependent-manner
#4
Sakie Funato, Rika Yasuhara, Kentaro Yoshimura, Yoichi Miyamoto, Kotaro Kaneko, Tetsuo Suzawa, Daichi Chikazu, Kenji Mishima, Kazuyoshi Baba, Ryutaro Kamijo
Osteoarthritis is a degenerative joint disease caused by excessive death of chondrocytes and loss of the extracellular matrix (ECM) in articular cartilage. We previously reported that reactive oxygen species (ROS) generated by the NADPH oxidase (NOX) isoform NOX-2 are involved in chondrocyte death induced by interleukin-1β (IL-1β). In this study, we investigate the role of NOX-2 in the production and degradation of ECM by chondrocytes. Although IL-1β lowered the mRNA expression of type II collagen (Col2a1) and aggrecan (Acan) in mouse chondrocyte-like ATDC5 cells, RNA silencing of Nox2 did not change the mRNA expression of these major components of the ECM of cartilage...
January 9, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28064031/frequency-of-temporomandibular-osteoarthritis-and-related-symptoms-in-a-hand-osteoarthritis-cohort
#5
Anna-Karin Abrahamsson, Margareth Kristensen, Linda Z Arvidsson, Tore K Kvien, Tore A Larheim, Ida K Haugen
OBJECTIVE: The prevalence of osteoarthritis (OA) in the temporomandibular joints (TMJs) in hand OA patients is largely unknown. Our aims were to explore 1) The frequency of TMJ-related symptoms and clinical findings; 2) The TMJ OA frequency defined by cone beam computed tomography (CBCT); and 3) The relationship between TMJ-related symptoms/clinical findings and CBCT-defined TMJ OA, in a hand OA cohort. METHODS: We calculated the frequencies of TMJ-related symptoms, clinical findings and diagnosis of TMJ OA by CBCT and clinical examination in 54 patients from the Oslo hand OA cohort (88% women, mean (range) age 71 (61-83) years)...
January 4, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28063649/biologic-drugs-as-analgesics-for-the-management-of-osteoarthritis
#6
REVIEW
Theodoros Dimitroulas, Tosin Lambe, Rainer Klocke, George D Kitas, Rui V Duarte
BACKGROUND: Biologic drugs are novel therapeutic agents with demonstrated effectiveness in the management of a variety of chronic inflammatory disorders. Unmet needs in the treatment of chronic pain have led physicians to utilize a similar approach to patients suffering from conditions not characterized by systemic inflammation such as osteoarthritis (OA). The aim of this review is to discuss the current knowledge on the use of commonly used biologic agents [i.e., anti-tumor necrosis factor alpha (anti-TNF alpha) and anti-nerve growth factor (anti-NGF)] for the management of OA...
December 5, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28054155/radiological-and-histological-analysis-of-two-replaced-interphalangeal-joints-with-active-subchondral-bone-resorption-in-erosive-hand-osteoarthritis-a-novel-mechanism
#7
Marta Favero, Giorgio Perino, Maria Luisa Valente, Cesare Tiengo, Roberta Ramonda
The aim of this study was to describe the histological features of erosive hand osteoarthritis (EHOA), which is considered an aggressive subset of hand osteoarthritis (OA) characterized by severe local inflammation and degeneration of the distal and proximal interphalangeal joints. Two patients with EHOA underwent replacement with a cement-free press fit ceramic prosthesis of a proximal interphalangeal joint (PIPJ). Clinical and radiological data were collected and histological examination was performed. Radiological examination with histological correlation showed complete erosion of the articular cartilage with focal presence of peripheral fibrocartilaginous resurfacing, sclerosis, and remodeling of the exposed bone, osteoclastic activity with resorptive lacunae in the subchondral bone and around degenerative fibromyxoid pseudocysts, coarse trabeculation of the cancellous bone, and marginal osteophytes...
January 4, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28053264/unconstrained-metacarpophalangeal-joint-arthroplasties-a-systematic-review
#8
R S Aujla, N Sheikh, P Divall, B Bhowal, J J Dias
AIMS: We performed a systematic review of the current literature regarding the outcomes of unconstrained metacarpophalangeal joint (MCPJ) arthroplasty. MATERIALS AND METHODS: We initially identified 1305 studies, and 406 were found to be duplicates. After exclusion criteria were applied, seven studies were included. Outcomes extracted included pre- and post-operative pain visual analogue scores, range of movement (ROM), strength of pinch and grip, satisfaction and patient reported outcome measures (PROMs)...
January 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28027679/the-comparison-of-telerehabilitation-and-face-to-face-rehabilitation-after-total-knee-arthroplasty-a-systematic-review-and-meta-analysis
#9
Shuihua Jiang, Jie Xiang, Xiuming Gao, Kaijin Guo, Baohua Liu
Introduction The objective of this study was to assess the efficacy of telerehabilitation for patients after total knee arthroplasty (TKA) compared with face-to-face rehabilitation. Methods Medline, SCOPUS, Google Scholar, EMBASE, Springer, Science Direct, and Cochrane databases were searched electronically. Relevant journals and references of studies included were hand-searched for randomized controlled trials (RCTs) regarding the efficacy of telerehabilitation on functional recovery in patients after TKA...
January 1, 2016: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28027044/evaluation-of-hand-forces-during-a-joint-protection-strategy-for-women-with-hand-osteoarthritis
#10
Corey McGee, Virgil Mathiowetz
OBJECTIVE: We evaluated whether a joint-protection strategy changes the mechanics of opening a sealed jar. METHOD: Thirty-one adult women with hand osteoarthritis attempted to open a "sealed" jar instrument when using and not using nonskid material. Grip force, torque, success, and pain were recorded for each trial. RESULTS: Participants used less grip force when twisting with their left hand. The greatest torque and success, yet the least amount of grip force across time, and pain was noted when the left hand turned the lid, the jar was held vertically, the right hand supported the base, and nonskid material was used...
January 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28026726/-intra-articular-application-of-tranexamic-acid-significantly-reduces-blood-loss-and-transfusion-requirement-in-primary-total-knee-arthroplasty
#11
J Lošťák, J Gallo, J Špička, K Langová
PURPOSE OF THE STUDY The aim of this prospective study was to investigate the effect of topical application of tranexamic acid (TXA, Exacyl) on the amount of post-operative blood loss, and blood transfusion requirement in patients undergoing primary total knee arthroplasty (TKA). Attention was paid to early complications potentially associated with TXA administration, such as haematoma, wound exudate, or knee swelling. In addition, the economic benefit of TXA treatment was also taken into account. MATERIAL AND METHODS The study included 238 patients (85 men and 153 women) who underwent primary total knee arthroplasty (TKA) at our department between January 2013 and November 2015...
2016: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28018082/ceramic-trapezio-metacarpal-arthroplasty-probably-half-is-better-than-full
#12
Rajesh Malhotra, Bhavuk Garg
Trapezio-metacarpal arthroplasty is one of the several treatment options available for painful first carpo-metacarpal (CMC) osteoarthritis of hand. In India, we have only Moje ceramic implants available for CMC arthroplasty. Although the literature cites high frequency of loosening and failure with use of Moje ceramic prostheses, all these studies describe results with total carpometacarpal arthroplasty. We expected that hemi-arthroplasty alone, by virtue of trapezium preservation leading to optimal capsular and ligament tensioning will provide good outcome...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28017944/-the-effects-of-exercise-and-sports-activities-on-bone-and-joint-morbidities
#13
Shinichi Yoshiya
Exercise and sports activities can afford mechanical stimuli to the bone and joint tissues which are required to maintain the tissue properties. Moreover, physical exercise is an important part of the management of bone and joint morbidities such as osteoporosis, osteoarthritis, and low back pain. On the other hand, excessive mechanical load involved in exercise and sports activities can be harmful potentially causing overuse injuries of the musculoskeletal tissues. Especially, safety margin for the amount of acceptable mechanical stress is narrow in the elderly due to preexisting musculoskeletal problems...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/27980229/il1r1-gene-polymorphisms-are-associated-with-knee-osteoarthritis-risk-in-the-chinese-han-population
#14
Yuyan Na, Rui Bai, Zhenqun Zhao, Yishan Wei, Daihe Li, Yong Wang, Chao Sun, Liang Sun, Bolun Zhang, Tianbo Jin, Wanlin Liu
IL1R1, encoding interleukin 1 receptor type 1, is located in the IL-1 gene cluster and is involved in the pathogenesis of hand, hip, and knee osteoarthritis (OA) in different ethnicities. However, the link between IL1R1 polymorphisms and OA risk in the Chinese Han population is unknown. We studied the association between five IL1R1 polymorphisms (rs10490571, rs12712127, rs956730, rs3917225, and rs3917318) and OA risk by analyzing the genotypes of 298 knee OA patients and 297 controls using Sequenom MassARRAY technology...
December 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27965137/osteoarthritis-year-in-review-2016-imaging
#15
REVIEW
Mikael Boesen, Karen Ellegaard, Marius Henriksen, Henrik Gudbergsen, Philip Hansen, Henning Bliddal, Else Marie Bartels, Robert Gabriel Riis
PURPOSE: The current narrative review covers original research related to imaging in osteoarthritis (OA) in humans published in English between April 1st 2015 and March 31st 2016, in peer reviewed journals available in Medline via PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) METHODS: Relevant studies in humans, subjectively decided by the authors, contributing significantly to the OA imaging field, were selected from an extensive Medline search using the terms "Osteoarthritis" in combination with "MRI", "Imaging", "Radiography", "X-rays", "Ultrasound", "Computed tomography", "Nuclear medicine", "PET-CT", "PET-MRI", "Scintigraphy", "SPECT"...
December 10, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27940594/the-comparison-of-magnetic-resonance-imaging-and-radiographs-to-assess-structural-progression-over-5-years-in-hand-osteoarthritis
#16
Ida Kristin Haugen, Barbara Slatkowsky-Christensen, Karwan Faraj, Désirée van der Heijde, Tore Kristian Kvien
OBJECTIVE: The aim was to explore the agreement between 1.0 T MRI and conventional radiography (CR) to detect progression of hand OA over 5 years and the associations between structural progression and incident joint tenderness. METHODS: Paired radiographs and paired MRIs of the second-fifth IP joints of the dominant hand from 69 hand OA patients were read for osteophytes, joint space narrowing and erosions. Patients with two or more joints demonstrating progression of any structural feature(s) were classified as progressors per imaging modality...
December 10, 2016: Rheumatology
https://www.readbyqxmd.com/read/27932358/association-between-lower-limb-osteoarthritis-and-incidence-of-depressive-symptoms-data-from-the-osteoarthritis-initiative
#17
Nicola Veronese, Brendon Stubbs, Marco Solmi, Toby O Smith, Marianna Noale, Cyrus Cooper, Stefania Maggi
BACKGROUND: osteoarthritis (OA) is associated with a number of medical morbidities. Although the prevalence of depression and depressive symptoms is presumed to be high in people with OA, no prospective comparative study has analyzed its incidence. OBJECTIVE: to determine whether OA was associated with an increased odds of developing depressive symptoms. DESIGN: longitudinal cohort study (follow-up: 4.2 years). SETTING: data were gathered from the North American Osteoarthritis Initiative (OAI) dataset...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27925193/systemic-and-local-adipose-tissue-in-knee-osteoarthritis
#18
REVIEW
Elisa Belluzzi, Hamza El Hadi, Marnie Granzotto, Marco Rossato, Roberta Ramonda, Veronica Macchi, Raffaele De Caro, Roberto Vettor, Marta Favero
Osteoarthritis is a common chronic joint disorder affecting older people. The knee is the major joint affected. The symptoms of osteoarthritis include limited range of motion, joint swelling, and pain causing disability. There are no disease modifying drugs available, and treatments are mainly focused on pain management. Total knee replacement performed at the end stage of the disease is considered the only cure available. It has been found that obese people have an increased risk to develop not only knee but also hand osteoarthritis...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27917705/efficacy-of-argane-oil-on-metabolic-syndrome-in-a-moroccan-knee-osteoarthritis-population
#19
Jamila Essouiri, Fatima Ezzahra Abourazzak, Faiza Lazrak, Adil Najdi, Nadia Benaicha, Taoufik Harzy, Mourad Errasfa
Five medical conditions characterizes metabolic syndrome: abdominal obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low high-density lipoproteins cholesterol. When a patient has three of the five above parameters, he is called to have metabolic syndrome, and these conditions represents a key element in cardiovascular diseases. On the other hand, knee osteoarthritis is a degenerative disease which was shown to be affected by some of the parameters of metabolic syndrome...
December 4, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27917634/-hand-osteoarthritis
#20
Ladislav Šenolt
Hand osteoarthritis (OA) is a common chronic disorder causing pain and limitation of mobility of affected joints. The prevalence of hand OA increases with age and more often affects females. Clinical signs obviously do not correlate with radiographic findings - symptomatic hand OA affects approximately 26 % of adult subjects, but radiographic changes can be found in up to two thirds of females and half of males older than 55 years.Disease course differ among individual patients. Hand OA is a heterogeneous disease...
2016: Casopís Lékar̆ů C̆eských
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