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Hand osteoarthritis

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https://www.readbyqxmd.com/read/29049177/association-of-bmp-14-rs143383-ploymorphism-with-its-susceptibility-to-osteoarthritis-a-meta-analysis-and-systematic-review-according-to-prisma-guideline
#1
Yi Yin, Yan Wang
BACKGROUND: Osteoarthritis (OA) is a complex disease which can be caused by both environmental and genetic factors. A functional locus rs143383 of bone morphogenetic protein-14 (BMP-14) has been pointed out to be associated with OA etiology, but conflicting conclusions have been reached. To provide a more comprehensive conclusion about this issue, we performed this meta-analysis. METHODS: Relevant studies were searched from electronic databases including PubMed, Chinese National Knowledge Infrastructure, Embase, and Wanfang...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29041020/-pilot-study-on-the-effects-and-benefits-of-autologous-fat-grafting-in-osteoarthritis-of-the-cmc-1-joint-compared-to-intraarticular-cortisone-injection-results-after-3-months
#2
Elisabeth Maria Haas, Elias Volkmer, Riccardo E Giunta
Background/Aim Preliminary data suggest that an intraarticular autologous fat transplant may be useful in osteoarthritis (OA) of the CMC-1 joint. This prospective, non-randomised pilot study investigates this new method with a view to clinical outcomes compared with intraarticular corticosteroid injection. Patients and Methods 17 women and 7 men with an average age of 63.3 (47-75) years with symptomatic OA were included in the study. In 12 patients, a radiologically guided injection of 1-1.5 ml of adipose tissue was carried out after transumbilical liposuction of 10 ml of abdominal fat...
October 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29040157/development-and-use-of-biochemical-markers-in-osteoarthritis-current-update
#3
Anne C Bay-Jensen, Christian S Thudium, Ali Mobasheri
PURPOSE OF REVIEW: There is an increasing demand for noninvasive and descriptive biochemical markers (biomarkers) in osteoarthritis; for enabling early drug development (including translational research), evaluating clinical trial at an early stage and for subtyping. Purpose of the review is to review and comment on current availability of such biomarkers. RECENT FINDINGS: Many different biomarkers have been tested in the last 18 months. The main focus has been on testing whether the biomarkers, whether is reflect joint tissue turnover or inflammatory status, can differentiate osteoarthritis patients from healthy controls or whether the biomarkers are associated with progression...
October 16, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29036545/rhizarthrosis-in-banknote-processing-workers-a-retrospective-cohort-study
#4
G Verrijdt, A De Landtsheer, A Mellen, L Godderis
Background: Rhizarthrosis, or osteoarthritis of the base of the thumb, is a common condition affecting 10-30% of the population over the age of 60. Whether it is an occupational disease has been the subject of debate as epidemiological studies on the correlation between physical stress and the presence of rhizarthrosis have shown conflicting results. Aims: To study the correlation between the prevalence of rhizarthrosis and the time spent by employees manually processing banknotes at the National Bank of Belgium (NBB)...
September 27, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29035931/bioactive-lipids-in-osteoarthritis-risk-or-benefit
#5
Andreea Ioan-Facsinay, Margreet Kloppenburg
PURPOSE OF REVIEW: Lipids are bioactive molecules that can affect several biological functions. Technological developments allowing identification of novel lipid species and the study of their function have led to a significant advance in our understanding of lipid biology and their involvement in various diseases. This is particularly relevant for diseases associated with obesity in which lipid accumulation could be involved in pathogenesis. Here, we focus on osteoarthritis, a chronic joint disease aggravated by obesity, and will present the latest findings regarding the involvement of lipids in disease development and progression...
October 13, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29035700/corrigendum-to-hydroxychloroquine-in-hand-oa-results-of-the-uk-hero-trial-osteoarthr-cartil-25-2017-s3-s4
#6
S R Kingsbury, P Tharmanathan, A Keding, S Ronaldson, A Grainger, R Wakefield, C Arundel, F Birrell, M Doherty, T Vincent, F E Watt, K Dziedzic, T O'Neill, N Arden, D L Scott, J Dickson, T Garrood, M Green, A Menon, T Sheeran, D Torgerson, P G Conaghan
No abstract text is available yet for this article.
October 13, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29032354/exercise-for-hand-osteoarthritis-a-cochrane-systematic-review
#7
Nina Østerås, Ingvild Kjeken, Geir Smedslund, Rikke H Moe, Barbara Slatkowsky-Christensen, Till Uhlig, Kåre Birger Hagen
OBJECTIVE: To assess the benefits and harms of exercise compared with other interventions, including placebo or no intervention, in people with hand osteoarthritis (OA). METHODS: Systematic review using Cochrane Collaboration methodology. Six electronic databases were searched up until September 2015. INCLUSION CRITERIA: randomized or controlled clinical trials comparing therapeutic exercise versus no exercise, or comparing different exercise programs...
October 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29030883/polyunsaturated-fatty-acids-influence-inflammatory-markers-in-a-cellular-model-for-canine-osteoarthritis
#8
N Adler, A Schoeniger, H Fuhrmann
Although it is well recognized that dietary supplementation with fish oil improves clinical symptoms in dogs suffering from osteoarthritis, the molecular basis for the dietary benefit is not yet completely resolved in dogs. This study was designed to further clarify how polyunsaturated fatty acids (PUFA) affect key factors of cartilage degeneration in a canine cell culture system mimicking osteoarthritis. Canine chondrocytes were incubated either without or with 10 μm of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA) or 3...
October 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29025602/complex-tibial-plateau-fractures-a-retrospective-study-and-proposal-of-treatment-algorithm
#9
Amerigo Menghi, Giuseppe Mazzitelli, Emanuele Marzetti, Francesco Barberio, Emanuela D'Angelo, Giulio Maccauro
INTRODUCTION: Complex tibial plateau fractures are characterized by compression and sinking of one or both the articular surfaces. In this study, we evaluated clinical and radiological outcomes in patients with 41.C1,41.C2,41.C3 fractures according to AO classification. We also provide a specific therapeutic algorithm for each type of fracture. MATERIAL AND METHODS: The study was conducted in 43 patients who underwent surgical treatment for complex tibial plateau fractures and were followed for a minimum of 12 months...
October 2017: Injury
https://www.readbyqxmd.com/read/29025096/efficacy-of-vibrating-gloves-for-chronic-hand-pain-due-to-osteoarthritis
#10
Robert N Jamison, Anna Mei, Robert R Edwards, Edgar L Ross
Objective: This study investigated the efficacy of vibration technology for women with hand pain due to osteoarthritis (OA) to see if mild compression and small vibrating motors were beneficial with periodic use. Methods: Sixty-nine (N = 69) women with OA hand pain were randomized into two groups, one that used vibrating gloves once a day for 20 minutes (Experimental, N = 34) and one that was monitored for three months without gloves (Control, N = 35)...
September 14, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29018060/dietary-supplements-for-treating-osteoarthritis-a-systematic-review-and-meta-analysis
#11
REVIEW
Xiaoqian Liu, Gustavo C Machado, Jillian P Eyles, Varshini Ravi, David J Hunter
OBJECTIVE: To investigate the efficacy and safety of dietary supplements for patients with osteoarthritis. DESIGN: An intervention systematic review with random effects meta-analysis and meta-regression. DATA SOURCES: MEDLINE, EMBASE, Cochrane Register of Controlled Trials, Allied and Complementary Medicine and Cumulative Index to Nursing and Allied Health Literature were searched from inception to April 2017. STUDY ELIGIBILITY CRITERIA: Randomised controlled trials comparing oral supplements with placebo for hand, hip or knee osteoarthritis...
October 10, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28990574/an-evidence-based-evaluation-on-the-use-of-platelet-rich-plasma-in-orthopedics-a-review-of-the-literature
#12
Nasir Hussain, Herman Johal, Mohit Bhandari
Within orthopedics, the use of platelet-rich plasma (PRP) has been rapidly increasing in popularity, however, its true effectiveness has yet to be fully established. Several studies find that injecting PRP to the site of injury does not provide any significant benefit with respect to clinical outcomes; however, many others report the contrary. Due to the conflicting evidence and multiple meta-analyses conducted on the topic, a literature review of high-quality evidence on the use of PRP for common orthopaedic conditions was performed...
2017: SICOT-J
https://www.readbyqxmd.com/read/28984654/joint-denervation-in-the-digits-technique-and-patient-satisfaction
#13
Russell J Madsen, Lindsay A Stone, Jeremiah B Knapp, Joel S Solomon
BACKGROUND: Traditional approaches to treating painful osteoarthritis of the fingers include arthrodesis and arthroplasty. Although highly effective for pain control, arthrodesis sacrifices joint motion and can be complicated by nonunion, malunion, and infection.Implant arthroplasty preserves motion but is likewise subject to complications-particularly at the level of the proximal interphalangeal joint. In contrast, finger joint denervation is a simple outpatient procedure that maintains joint motion...
October 3, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28977564/population-trends-in-the-incidence-and-initial-management-of-osteoarthritis-age-period-cohort-analysis-of-the-clinical-practice-research-datalink-1992-2013
#14
Dahai Yu, Kelvin P Jordan, John Bedson, Martin Englund, Fiona Blyth, Aleksandra Turkiewicz, Daniel Prieto-Alhambra, George Peat
Objective: To determine recent trends in the rate and management of new cases of OA presenting to primary healthcare using UK nationally representative data. Methods: Using the Clinical Practice Research Datalink we identified new cases of diagnosed OA and clinical OA (including OA-relevant peripheral joint pain in those aged over 45 years) using established code lists. For both definitions we estimated annual incidence density using exact person-time, and undertook descriptive analysis and age-period-cohort modelling...
August 4, 2017: Rheumatology
https://www.readbyqxmd.com/read/28973832/improved-hand-function-self-rated-health-and-decreased-activity-limitations-results-after-a-two-month-hand-osteoarthritis-group-intervention
#15
Linda Bjurehed, Nina Brodin, Ulla Nordenskiöld, Mathilda Björk
INTRODUCTION: Hand Osteoarthritis (hand OA) causes pain, impaired mobility and reduced grip force, which cause activity limitations. Osteoarthritis group interventions in primary care settings are sparsely reported. PURPOSE: To evaluate the effects on hand function, activity limitations and self-rated health of a primary care hand OA group intervention. METHOD: 64 individuals with hand OA agreed to participate, 15 were excluded due to not fulfilling the inclusion criteria...
October 3, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28953990/metabolomics-as-a-promising-tool-for-early-osteoarthritis-diagnosis
#16
REVIEW
E B de Sousa, G C Dos Santos, M E L Duarte, V Moura, D P Aguiar
Osteoarthritis (OA) is the main cause of disability worldwide, due to progressive articular cartilage loss and degeneration. According to recent research, OA is more than just a degenerative disease due to some metabolic components associated to its pathogenesis. However, no biomarker has been identified to detect this disease at early stages or to track its development. Metabolomics is an emerging field and has the potential to detect many metabolites in a single spectrum using high resolution nuclear magnetic resonance (NMR) techniques or mass spectrometry (MS)...
September 21, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28947452/a-hospital-based-observational-cohort-study-exploring-pain-and-biomarkers-in-patients-with-hand-osteoarthritis-in-norway-the-nor-hand-protocol
#17
Marthe Gløersen, Elisabeth Mulrooney, Alexander Mathiessen, Hilde Berner Hammer, Barbara Slatkowsky-Christensen, Karwan Faraj, Thore Isaksen, Tuhina Neogi, Tore K Kvien, Karin Magnusson, Ida Kristin Haugen
INTRODUCTION: We have limited knowledge about the underlying disease mechanisms and causes of pain in hand osteoarthritis (OA). Consequently, no disease-modifying drug exists, and more knowledge about the pathogenesis of hand OA is needed, as well as a validation of different outcome measures. Our first aim of this study is to explore the validity of various imaging modalities for the assessment of hand OA. Second, we want to gain a better understanding of the disease processes, with a special focus on pain mechanisms...
September 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28946838/randomized-controlled-trial-comparing-efficacy-of-conventional-and-new-single-larger-dose-of-intra-articular-viscosupplementation-in-management-of-knee-osteoarthritis
#18
Vijaya Kumar L Suppan, Chew Yu Wei, Tan Chin Siong, Tew Mei Mei, Wong Bor Chern, Vijay Kumar Nanta Kumar, Kee Rong Sheng, Ashutosh Sadashiva Rao
BACKGROUND: Intra-articular hyaluronic acid (HA) injection is used in management of knee, hand and hip osteoarthritis. While HA injection is included in the list of evaluated therapies, its efficacy and optimum dosing still have no consensus. This study was conducted to explore the possibility of using single injection HA to increase patient convenience while maintaining the therapeutic efficacy. METHODS: We present a prospective, open label, non-blinded, randomized controlled trial performed in accordance with guidelines in principles of good clinical practice...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28934868/the-auscan-and-prwhe-demonstrate-comparable-internal-consistency-and-validity-in-patients-with-early-thumb-carpometacarpal-osteoarthritis
#19
Thomas J McQuillan, Molly M Vora, Deborah E Kenney, Joseph J Crisco, Arnold-Peter C Weiss, Kerry A Ebert, Kathleen E Snelgrove, Alexandra Sarnowski, Amy L Ladd
BACKGROUND: The Australian/Canadian Osteoarthritis Hand Index (AUSCAN) and Patient-Rated Wrist-Hand Evaluation (PRWHE) are 2 patient-related outcome measures to assess pain and disability in patients with osteoarthritis (OA). The purpose of this study was to evaluate the AUSCAN and PRWHE in a large-scale, longitudinal cohort of patients with early thumb carpometacarpal (CMC) OA. METHODS: We obtained baseline data on 135 individuals (92 with early CMC OA participants and 43 asymptomatic controls) and at follow-up (year 1...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28934632/in-vivo-biomechanical-behavior-of-the-trapeziometacarpal-joint-in-healthy-and-osteoarthritic-subjects
#20
Priscilla D'Agostino, Benjamin Dourthe, Faes Kerkhof, G Harry Van Lenthe, Filip Stockmans, Evie E Vereecke
BACKGROUND: The contact biomechanics of the trapeziometacarpal joint have been investigated in several studies. However, these led to conflicting results and were mostly performed in vitro. The purpose of this study was to provide further insight on the contact biomechanics of the trapeziometacarpal joint by in vivo assessment of healthy and osteoarthritic subjects. METHODS: The hands of 16 healthy women and 6 women with trapeziometacarpal osteoarthritis were scanned in positions of maximal thumb extension, flexion, abduction and adduction during three isometric tasks (lateral key pinch, power grasp and jar twist) and in thumb rest posture (relaxed neutral)...
September 12, 2017: Clinical Biomechanics
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