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HIPEC

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https://www.readbyqxmd.com/read/28431896/pressurized-intraperitoneal-aerosol-chemotherapy-%C3%A2-practical-aspects
#1
M Hübner, F Grass, H Teixeira-Farinha, B Pache, P Mathevet, N Demartines
INTRODUCTION: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) has been introduced as novel treatment for peritoneal carcinomatosis. Only proper patient selection, stringent safety protocol and careful surgery allow for a secure procedure. We hereby report the essentials for safe implementation. METHODS: All consecutive procedures within 20 months after PIPAC implementation were analyzed with regards to practical and surgical aspects. Special emphasis was laid on modifications of technique and safety measures during the implementation process with systematic use of a dedicated checklist...
April 8, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28415645/peritoneal-carcinomatosis-limits-of-diagnosis-and-the-case-for-liquid-biopsy
#2
REVIEW
James R W McMullen, Matthew Selleck, Nathan R Wall, Maheswari Senthil
Peritoneal Carcinomatosis (PC) is a late stage manifestation of several gastrointestinal malignancies including appendiceal, colorectal, and gastric cancer. In PC, tumors metastasize to and deposit on the peritoneal surface and often leave patients with only palliative treatment options. For colorectal PC, median survival is approximately five months, and palliative systemic therapy is able to extend this to approximately 12 months. However, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) with a curative intent is possible in some patients with limited tumor burden...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411306/is-fecal-diversion-needed-in-pelvic-anastomoses-during-hyperthermic-intraperitoneal-chemotherapy-hipec
#3
Matthew D Whealon, John V Gahagan, Sarath Sujatha-Baskar, Michael P O'Leary, Matthew Selleck, Sinziana Dumitra, Byrne Lee, Maheswari Senthil, Alessio Pigazzi
BACKGROUND: The role of fecal diversion with pelvic anastomosis during cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is not well defined. METHODS: A retrospective review of patients who underwent CRS and HIPEC between 2009 and 2016 was performed to identify those with a pelvic anastomosis (colorectal, ileorectal, or coloanal anastomosis). RESULTS: The study identified 73 patients who underwent CRS and HIPEC at three different institutions between July 2009 and June of 2016...
April 14, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28409831/postoperative-complications-affect-long-term-outcomes-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-colorectal-peritoneal-carcinomatosis
#4
Lawrence Lee, Fanny Alie-Cusson, Pierre Dubé, Lucas Sideris
BACKGROUND AND OBJECTIVES: Morbidity after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) for colorectal peritoneal carcinomatosis (PC) may negatively affect survival. The objective was to determine the impact of postoperative complications (CX) on survival in patients undergoing CRS + HIPEC for colorectal PC. METHODS: All patients undergoing laparotomy for planned CRS + HIPEC for colorectal PC at a single institution from 1999 to 2014 were included...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28404198/molecular-fluorescence-guided-surgery-of-peritoneal-carcinomatosis-of-colorectal-origin-a-single-centre-feasibility-study
#5
Niels J Harlaar, Marjory Koller, Steven J de Jongh, Barbara L van Leeuwen, Patrick H Hemmer, Schelto Kruijff, Robert J van Ginkel, Lukas B Been, Johannes S de Jong, Gursah Kats-Ugurlu, Matthijs D Linssen, Annelies Jorritsma-Smit, Marleen van Oosten, Wouter B Nagengast, Vasilis Ntziachristos, Gooitzen M van Dam
BACKGROUND: Optimum cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is essential for the curative treatment of peritoneal carcinomatosis of colorectal origin. At present, surgeons depend on visual inspection and palpation for tumour detection. Improved detection of tumour tissue using molecular fluorescence-guided surgery could not only help attain a complete cytoreduction of metastatic lesions, but might also prevent overtreatment by avoiding resection of benign lesions...
December 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28400138/influence-of-simultaneous-liver-and-peritoneal-resection-on-postoperative-morbi-mortality-and-survival-in-patients-with-colon-cancer-treated-with-surgical-cytoreduction-and-intraperitoneal-hyperthermic-chemotherapy
#6
Rafael Morales Soriano, José Miguel Morón Canis, Xavier Molina Romero, Judit Pérez Celada, Silvia Tejada Gavela, Juan José Segura Sampedro, Patricia Jiménez Morillas, Paula Díaz Jover, José María García Pérez, Fátima Sena Ruiz, Xavier González Argente
INTRODUCTION: Cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy (HIPEC) has recently been established as the treatment of choice for selected patients with peritoneal carcinomatosis of colonic origin. Until recently, the simultaneous presence of peritoneal and hepatic dissemination has been considered a contraindication for surgery. The aim of this paper is to analyze the morbidity, mortality and survival of patients with simultaneous peritoneal and hepatic resection with HIPEC for peritoneal carcinomatosis secondary to colon cancer...
April 9, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28399919/long-term-survival-of-high-grade-primary-peritoneal-papillary-serous-adenocarcinoma-a-case-report-and-literature-review
#7
Jingping Yuan, Liang He, Bing Han, Yan Li
BACKGROUND: Primary peritoneal papillary serous carcinoma (PPPSC) is an uncommon disease which has a high malignancy and a poor prognosis. CASE PRESENTATION: We report here a long-term survival case of PPPSC with postoperative lung metastasis. A 62-year-old female patient with PPPSC was administered two cycles of neoadjuvant chemotherapy (NAC) followed by cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) and six cycles of platinum-based (docetaxel + carboplatin) intraperitoneal chemotherapy postoperatively...
April 11, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28393331/role-of-crs-and-hipec-in-appendiceal-and-colorectal-malignancies-indian-experience
#8
Nikhil Gupta, Syed Asif, Jatin Gandhi, Sajjan Rajpurohit, Shivendra Singh
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy are recently being considered as standard of treatment for patients with peritoneal carcinomatosis of appendiceal or colorectal origin. It is an extensive procedure with high morbidity. Being a newer treatment modality, not much experience has been published from an Indian center about it. METHODS: All patients of colorectal and appendiceal cancer with peritoneal metastasis from January 2012 to March 2015 who were planned for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) were analyzed with respect to morbidity, mortality, and survival...
April 10, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28373757/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-treatment-of-gastric-cancer-with-peritoneal-carcinomatosis
#9
Lynne M Ellison, Yangao Man, Alexander Stojadinovic, Hongwu Xin, Itzhak Avital
Although gastric cancer with peritoneal carcinomatosis is associated with poor prognosis and is generally treated with palliative systemic therapy, recent studies have shown that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may prove to be an efficacious treatment option. In addition to reviewing the natural history of gastric cancer with peritoneal carcinomatosis, this mini-review examines literature on the efficacy of CRS and HIPEC as compared to chemotherapy and surgical options...
February 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28365962/outcomes-of-cytoreductive-surgery-and-hipec-for-pseudomyxoma-peritonei-of-appendiceal-origin-from-two-indian-centers-a-preliminary-five-year-experience
#10
Aditi Bhatt, Deepak Sheshadri, Garud Chandan, Veena Ramaswamy, Jeegeshwar Pandey, Nitin Bhorkar, Deepesh Agrawal, Sanket Mehta
PURPOSE: To evaluate the short-term outcomes of patients of pseudomyxoma peritonei (PMP) of appendiceal origin treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) at two tertiary Indian centers. METHODS: Data was prospectively collected from January 2011 to January 2016. Palliative procedures were excluded. HIPEC was performed by the coliseum technique using either a mitomycin or oxaliplatin-based regimen. RESULTS: 77 procedures were performed on 71 patients...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28342015/a-prognostic-model-for-predicting-overall-survival-in-patients-with-peritoneal-surface-malignancy-of-an-appendiceal-origin-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#11
Chukwuemeka Ihemelandu, Stephen Fernandez, Paul H Sugarbaker
INTRODUCTION: Our aim was to develop a prognostic model for predicting overall survival following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with appendiceal adenocarcinoma and peritoneal metastasis. METHODS: A retrospective analysis of a prospectively maintained database for all patients treated for appendiceal adenocarcinoma with peritoneal metastasis from 1989 to 2012 was conducted. RESULTS: Overall, 734 (50...
March 24, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28331493/feasibility-and-safety-of-pressurized-intraperitoneal-aerosol-chemotherapy-for-peritoneal-carcinomatosis-a-retrospective-cohort-study
#12
Martin Hübner, Hugo Teixeira Farinha, Fabian Grass, Anita Wolfer, Patrice Mathevet, Dieter Hahnloser, Nicolas Demartines
Background. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has been introduced as a novel repeatable treatment for peritoneal carcinomatosis. The available evidence from the pioneer center suggests good tolerance and high response rates, but independent confirmation is needed. A single-center cohort was analyzed one year after implementation for feasibility and safety. Methods. PIPAC was started in January 2015, and every patient was entered into a prospective database. This retrospective analysis included all consecutive patients operated until April 2016 with emphasis on surgical feasibility and early postoperative outcomes...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28330549/-hyperthermic-intraperitoneal-chemotherapy-at-the-primary-gastrointestinal-cancer-operation
#13
Thea Helene Degett, Hans-Christian Pommergaard, Ismail Gögenur
Up to 20% of the patients who undergo radical surgery for colorectal cancer experience recurrence. Hyperthermic intraperitoneal chemotherapy (HIPEC) and cytoreductive surgery have shown to be effective treatment of peritoneal carcinomatosis. HIPEC administered at the primary operation in high-risk patients may also be effective in preventing peritoneal carcinomatosis and improve survival in patients with advanced gastrointestinal cancer.
March 20, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28324285/preoperative-thrombocytosis-predicts-shortened-survival-in-patients-with-malignant-peritoneal-mesothelioma-undergoing-operative-cytoreduction-and-hyperthermic-intraperitoneal-chemotherapy
#14
Yue C Li, Tamara Khashab, Julia Terhune, Richard L Eckert, Nader Hanna, Allen Burke, H Richard Alexander
BACKGROUND: This study was designed to determine the clinical significance of preoperative thrombocytosis in patients with malignant peritoneal mesothelioma (MPM) undergoing operative cytoreduction (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). CRS and HIPEC have been associated with prolonged survival in patients with MPM and is the preferred treatment in select patients. However, patient selection criteria remain ill-defined for this operation that is also associated with significant morbidity and mortality...
March 21, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28317586/strategies-to-improve-local-control-of-resected-pancreas-adenocarcinoma
#15
Paul H Sugarbaker
BACKGROUND: Only approximately one in ten pancreas cancer patients is a candidate for potentially curative resection of this disease. Even this small fraction of patients has a poor prognosis following pancreatico-duodenectomy. The disease has an anatomic location that makes it difficult for the surgeon to maintain adequate margins of resection and prevent tumor spillage at the time of resection. Also, the disease is biologically aggressive and even with a complete visible resection of the disease, micrometastases are likely to remain behind...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28315061/external-validation-of-the-simplified-preoperative-assessment-for-low-grade-mucinous-adenocarcinoma-of-the-appendix
#16
Vladimir Milovanov, Armando Sardi, Nail Aydin, Carol Nieroda, Michelle Sittig, Vadim Gushchin
BACKGROUND: MD Anderson Cancer Center developed a computed tomography (CT)-based preoperative assessment tool simplified preoperative assessment for appendix tumor (SPAAT) for predicting incomplete cytoreduction (IC) in low-grade mucinous adenocarcinoma (LGMA) of the appendix, based on preoperative CT scans. This study independently evaluates the tool's performance. METHODS: Seventy-six preoperative CT scans of LGMA patients were evaluated by two surgeons unfamiliar with the patients' medical history...
March 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28291907/the-effects-of-hyperthermic-intraperitoneal-chemoperfusion-on-colonic-anastomosis-an-experimental-study-in-a-rat-model
#17
Afag Aghayeva, Cigdem Benlice, Ismail Ahmet Bilgin, Pinar Atukeren, Gulen Dogusoy, Figen Demir, Deniz Atasoy, Bilgi Baca
INTRODUCTION: Cytoreductive surgery (CRS) with subsequent hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising modality to treat and prevent peritoneal metastases. However, this treatment is associated with signficant morbidity and mortality. Whether or not CRS with HIPEC interferes with anastomotic healing has also been debated. This study was designed to investigate the effects of mitomycin C, cisplatin, oxaliplatin, and doxorubicin used in HIPEC treatment on colonic anastomosis healing in a rat model...
February 28, 2017: Tumori
https://www.readbyqxmd.com/read/28289659/single-center-experience-with-hyperthermic-intraperitoneal-chemotherapy
#18
Woo Ram Kim, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim
PURPOSE: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been proposed for controlling peritoneal seeding metastasis in some kinds of cancers, including those of colorectal origin, but their safety and oncological benefits are subjects of debate. We present our early experience with those procedures. METHODS: Data were retrospectively collected from all patients with peritoneal carcinomatosis (PC) and pseudomyxoma peritonei (PMP) treated using CRS and HIPEC at Yonsei Cancer Center between July 2014 and July 2015...
February 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28273222/exploring-flow-rate-selection-in-hipec-procedures
#19
Thales Paulo Batista, Levon Badiglian Filho, Cristiano Souza Leão
Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as a main comprehensive treatment of peritoneal malignancies. However, current data on the literature are very heterogeneous in terms of its technical particularities, which require some efforts to standardization of practices. In these setting, we present some early data from a pioneering clinical trial in Brazil (ClinicalTrials.gov Identifier: NCT02249013) to explore the dynamic relationships between flow rates and temperature parameters in the first cases of our study, which may help in selecting better technical parameters during HIPEC procedures...
December 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28265776/major-postoperative-complications-are-a-risk-factor-for-impaired-survival-after-crs-hipec
#20
Marcel André Schneider, Dilmurodjon Eshmuminov, Kuno Lehmann
BACKGROUND: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a combined treatment option for well-selected patients with peritoneal carcinomatosis (PC). The study aimed to identify factors influencing cancer-specific survival (CSS) and disease-free survival (DFS). METHODS: Data of 113 patients with colorectal or appendicular carcinomatosis from a single center operated between 2009 and 2014 were retrospectively collected and analyzed...
March 6, 2017: Annals of Surgical Oncology
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