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https://www.readbyqxmd.com/read/29159742/validation-of-the-recent-psogi-pathological-classification-of-pseudomyxoma-peritonei-in-a-single-center-series-of-265-patients-treated-by-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#1
Dario Baratti, Shigeki Kusamura, Massimo Milione, Federica Bruno, Marcello Guaglio, Marcello Deraco
BACKGROUND: Controversies still persist regarding the terminology and pathologic classification of appendiceal mucinous neoplasms and associated pseudomyxoma peritonei (PMP). We assessed reproducibility and prognostic significance of the classification recently proposed by the Peritoneal Surface Oncology Group International (PSOGI). METHODS: A prospective database of 265 PMP patients uniformly treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) from 1995 to 2017 was reviewed...
November 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29154241/przerzuty-do-otrzewnej-raka-jelita-grubego
#2
Tomasz Jastrzębski, Wojciech Zegarski
Częstość przerzutów do otrzewnej w raku jelita grubego wynosi 5%-15% w przypadku przerzutów synchronicznych i aż 40% w przypadku wystąpienia wznowy miejscowej. Najlepsze wyniki leczenia uzyskuje się poprzez skojarzone wykonanie zabiegu cytoredukcyjnego w połączeniu z dootrzewnową chemioterapią perfuzyjną w hipertermii (HIPEC). Wyniki takiego leczenia są zdecydowanie lepsze i pozwalają na osiągnięcie przeżyć 5-letnich na poziomie 30%-50%. Zabiegi te wymagają dużego doświadczenia w chirurgii jamy brzusznej, są czasochłonne (średni czas procedury chirurgicznej wynosi 6-8 godzin) i obarczone powikłaniami związanymi nie tylko z zabiegiem operacyjnym, ale także podaniem cytostatyku do jamy otrzewnej w podwyższonej temperaturze (41,5 st...
October 31, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29137079/treatment-of-hypermyoglobinemia-after-crs-hipec-for-patients-with-peritoneal-carcinomatosis-a-retrospective-comparative-study
#3
Gang Liu, Zhong-He Ji, Yang Yu, Xin-Bao Li, Yan-Bin Zhang, Kai-Wen Peng, Yan Li
This retrospective comparative study aims to explore the time courses of serum myoglobin (Mb) changes, and summarize our experience in treating patients with hypermyoglobinemia after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).This study covered 60 patients with peritoneal carcinomatosis treated with CRS + HIPEC as the study group, and another 25 cancer patients treated with conventional extensive surgery without HIPEC as the control group from February to October 2016...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135123/hepatobiliary-and-pancreatic-procedures-during-cytoreductive-surgery-and-hipec
#4
Ioannis Kyriazanos, Nikolaos Kopanakis, Vasileios Kalles, Alexios Tzivanakis, Georgios Nikolaou, Elias Efstathiou, John Spiliotis
PURPOSE: The combination of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has been used as locoregional treatment in selected patients with peritoneal malignancy. The purpose of this study was to report on the outcomes of patients undergoing hepatobiliary and pancreatic procedures during CRS and HIPEC. METHODS: A prospectively maintained database was used to identify patients that underwent hepatobilliary and/or pancreatic procedures during CRS and HIPEC...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29135095/does-upfront-therapy-with-cytoreductive-surgery-and-hipec-confer-a-survival-benefit-in-patients-with-synchronous-gastric-peritoneal-carcinomatosis-when-compared-with-patients-with-metachronous-gastric-peritoneal-carcinomatosis
#5
Nikolaos Kopanakis, Elias Efstathiou, Dimitrios Sarris, John Spiliotis
Gastric cancer (GC) remains the second leading cause of cancer death worldwide, accounting for 8% of the total cases and 10% of total deaths in 2008. Surgery remains the curative treatment option for GC and the main reason for treatment failure is peritoneal recurrence which, according to the literature, occurs in 40-60% of the cases, despite extensive surgery including D2 lymph node dissection. The hyperthermic intraperitoneal chemotherapy (HIPEC) technique is increasingly used in the treatment of primary and digestive peritoneal carcinomatosis (PC), in association with cytoreductive surgery (CRS)...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29132061/synchronous-peritoneal-metastases-of-small-bowel-adenocarcinoma-insights-into-an-underexposed-clinical-phenomenon
#6
Laura M Legué, Geert A Simkens, Geert-Jan M Creemers, Valery E P P Lemmens, Ignace H J T de Hingh
BACKGROUND: The aim of this population-based study was to provide insight into the incidence, risk factors and treatment-related survival of patients with peritoneal metastases (PM) of small bowel adenocarcinoma (SBA). METHODS: Data from the Netherlands Cancer Registry were used. All patients diagnosed with SBA between 2005 and 2014 were included. The influence of patient and tumour characteristics on the odds of developing PM was analysed. Subsequently, for all further analyses, patients without synchronous PM of SBA were excluded...
November 10, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29131272/hipec-and-the-necessary-hyperthermia-do-we-still-need-the-open-abdomen
#7
M Lotti
No abstract text is available yet for this article.
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29131271/reply-to-the-letter-hipec-and-the-necessary-hyperthermia-do-we-still-need-the-open-abdomen
#8
D Di Miceli
No abstract text is available yet for this article.
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29120491/clinical-studies-in-crs-and-hipec-trials-tribulations-and-future-directions-a-systematic-review
#9
William F Morano, Marian Khalili, Dennis S Chi, Wilbur B Bowne, Jesus Esquivel
BACKGROUND: The field of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has suffered from a lack of clinical trials to validate its expanding use. OBJECTIVE: To evaluate published and ongoing clinical trials seeking to better define role of CRS/HIPEC in the treatment of peritoneal surface malignancies. METHODS: Systematic review by PubMed search was performed using terms "Clinical trial," "intraperitoneal chemotherapy," and "HIPEC...
November 9, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29110275/impact-of-cellularity-on-oncologic-outcomes-following-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemoperfusion-for-pseudomyxoma-peritonei
#10
Haroon A Choudry, Reetesh K Pai, Yongli Shuai, Lekshmi Ramalingam, Heather L Jones, James F Pingpank, Steven S Ahrendt, Matthew P Holtzman, Amer H Zureikat, Herbert J Zeh, David L Bartlett
BACKGROUND: The Peritoneal Surface Oncology Group International (PSOGI) recommends pathologic reporting of tumor cellularity in patients with pseudomyxoma peritonei (PMP) undergoing cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion (CRS-HIPEC). We investigated the prognostic significance of PMP cellularity, or lack thereof (acellular mucin), following CRS-HIPEC. METHODS: We reviewed clinical data for 310 CRS-HIPEC procedures in low-grade (American Joint Committee on Cancer grade G1) PMP with acellular mucin (n = 19), scant cellularity (n = 30), or moderate cellularity (n = 242)...
November 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29108718/a-new-animal-model-for-hyperthermic-intraperitoneal-chemotherapy-hipec-in-tumor-bearing-mice-in-the-treatment-of-peritoneal-carcinomatosis-of-ovarian-origin
#11
G Miailhe, A Arfi, M Mirshahi, C Eveno, M Pocard, C Touboul
AIM OF THE STUDY: We set out to develop and evaluate the morbidity of a non-invasive hyperthermic intraperitoneal chemotherapy (HIPEC) procedure in mice. HIPEC has been shown to improve overall survival in treating ovarian cancer with peritoneal carcinomatosis. However, related complications, toxicity and the lack of randomized trials limits its widespread use. To improve the surgical technique, there is a need for animal models that allow teams to work on large groups without burdensome logistics...
November 3, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29100461/nanoparticle-as-a-novel-tool-in-hyperthermic-intraperitoneal-and-pressurized-intraperitoneal-aerosol-chemotheprapy-to-treat-patients-with-peritoneal-carcinomatosis
#12
REVIEW
Maciej Nowacki, Margarita Peterson, Tomasz Kloskowski, Eleanor McCabe, Delia Cortes Guiral, Karol Polom, Katarzyna Pietkun, Barbara Zegarska, Marta Pokrywczynska, Tomasz Drewa, Franco Roviello, Edward A Medina, Samy L Habib, Wojciech Zegarski
The treatment of peritoneal surface malignances has changed considerably over the last thirty years. Unfortunately, the palliative is the only current treatment for peritoneal carcinomatosis (PC). Two primary intraperitoneal chemotherapeutic methods are used. The first is combination of cytoreductive surgery (CRS) and Hyperthermic IntraPEritoneal Chemotherapy (HIPEC), which has become the gold standard for many cases of PC. The second is Pressurized IntraPeritoneal Aerosol Chemotheprapy (PIPAC), which is promising direction to minimally invasive as safedrug delivery...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29090402/factors-associated-with-60-day-readmission-following-cytoreduction-and-hyperthermic-intraperitoneal-chemotherapy
#13
Kaitlyn J Kelly, Luis Cajas, Joel M Baumgartner, Andrew M Lowy
INTRODUCTION: Readmission rates following surgery are subject to scrutiny in efforts to control health care costs. This study was designed to define the 60-day readmission rate following cytoreduction and HIPEC at a high-volume center and to identify factors associated with readmission. METHODS: Patients who underwent complete cytoreduction and HIPEC at a single institution from August 2007 through June 2014 were identified from a prospectively maintained database...
October 31, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29089784/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-appendiceal-goblet-cell-carcinomas-with-peritoneal-carcinomatosis-results-from-a-single-specialized-center
#14
Hsin-Hsien Yu, Yutaka Yonemura, Mao-Chih Hsieh, Akiyoshi Mizumoto, Satoshi Wakama, Chang-Yun Lu
BACKGROUND: Goblet cell carcinomas (GCCs) of the appendix are rare and aggressive malignancies with early peritoneal dissemination. The aim of the present article is to describe our experience in the management of GCCs with peritoneal carcinomatosis (PC) through cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) and to determine the impact of multiple clinical characteristics on the prognosis. METHODS: From a prospectively maintained database of patients receiving CRS and HIPEC for peritoneal surface malignancy, the data of 15 patients with GCC and PC were collected...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29078882/safety-and-efficacy-of-combined-resection-of-colorectal-peritoneal-and-liver-metastases
#15
Stephanie Downs-Canner, Yongli Shuai, Lekshmi Ramalingam, James F Pingpank, Matthew P Holtzman, Herbert J Zeh, David L Bartlett, Haroon A Choudry
BACKGROUND: To determine if a select subgroup of patients with combined liver and peritoneal colorectal metastases would derive oncologic benefit from surgical resection as a component of multimodality treatment. MATERIALS AND METHODS: We retrospectively compared 32 patients with combined colorectal peritoneal and liver metastases (CRLM) and 173 patients with peritoneal metastases only (CRPM) undergoing cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (CRS-HIPEC)...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29070431/cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec-for-disseminated-intraabdominal-malignancies-in-children-a-single-institution-experience
#16
Osnat Zmora, Andrea Hayes-Jordan, Aviram Nissan, Iris Kventsel, Yoram Newmann, Kira Itskovsky, Shifra Ash, Sarina Levy-Mendelovich, Daniel Shinhar, Almog Ben-Yaakov, Amos Toren, Ron Bilik
PURPOSE: Our purpose was to present our institutional experience with performing complete cytoreduction surgery and heated intraoperative chemotherapy (CRS-HIPEC) for children with disseminated intraabdominal malignancies, guided by a leading international center performing CRS-HIPEC in children. METHODS: Retrospective chart review of all cases of CRS-HIPEC in children in our institution, examining diagnosis, preoperative management, operative management, postoperative treatment, short term outcome including length of stay and complications, and long term outcome including survival and recurrence of disease...
October 2, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29063804/the-pre-operative-neutrophil-lymphocyte-ratio-predicts-overall-and-disease-free-survival-following-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec-in-patients-with-pseudomxyoma-peritonei-of-appendiceal-origin
#17
Karan Rangarajan, Kandiah Chandrakumaran, Sanjeev Dayal, Faheez Mohamed, Brendan J Moran, Thomas D Cecil
AIM: The neutrophil-lymphocyte ratio (NLR) and other inflammation-based scores have been used as a prognostic tool to predict survival in solid tumours including pseudomyxoma peritonei (PMP). The aim was to evaluate the prognostic value of this marker and risk stratify PMP patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: Retrospective analysis was conducted of a prospectively collected database of patients with PMP who underwent CRS and HIPEC between 1994 and 2015...
October 24, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29063295/long-term-outcomes-after-r0-resection-of-synchronous-peritoneal-metastasis-from-colorectal-cancer-without-cytoreductive-surgery-or-hyperthermic-intraperitoneal-chemotherapy
#18
Dai Shida, Shunsuke Tsukamoto, Hiroki Ochiai, Yukihide Kanemitsu
BACKGROUND: The National Comprehensive Cancer Network (NCCN) guidelines for colon cancer recently added the following footnote regarding the therapeutic strategy for peritoneal metastases: "If R0 resection can be achieved, surgical resection of isolated peritoneal disease may be considered at experienced centers." This study investigated the efficacy of R0 resection of peritoneal metastasis from colorectal cancer without cytoreductive surgery or hyperthermic intraperitoneal chemotherapy (HIPEC)...
October 23, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29031954/suitability-of-the-auc-ratio-as-an-indicator-of-the-pharmacokinetic-advantage-in-hipec
#19
M I Mas-Fuster, A Ramon-Lopez, J Lacueva, P Más-Serrano, R Nalda-Molina
PURPOSE: The purpose of this study was to evaluate the area under the concentration time curve (AUC) ratio as an optimal indicator of the pharmacokinetic advantage during hyperthermic intraperitoneal perioperative chemotherapy (HIPEC). METHODS: The impact on the AUC ratio on the variables related to the calculation of systemic drug exposure, instillation time and peripheral drug distribution was evaluated through simulations as well as through a retrospective analysis of studies published in the literature...
October 12, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29027153/conflicting-data-on-the-incidence-of-leukopenia-and-neutropenia-after-heated-intraperitoneal-chemotherapy-with-mitomycin-c
#20
Yael Feferman, Shanel Bhagwandin, Joseph Kim, Samantha N Aycart, Daniela Feingold, Daniel M Labow, Umut Sarpel
BACKGROUND: During heated intraperitoneal chemotherapy (HIPEC), neutropenia rates of 20 to 40% have been reported when mitomycin C (MMC) is dosed by weight or body surface area (BSA). This study investigated the authors' HIPEC experience using a fixed 40-mg dose of MMC, per consensus guidelines, and analyzed predictors for severe leukopenia and neutropenia. METHODS: Patients who underwent MMC-HIPEC from 2007 to 2016 at a single tertiary care center were retrospectively reviewed...
October 12, 2017: Annals of Surgical Oncology
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