keyword
https://read.qxmd.com/read/37992760/the-influence-of-propolis-plus-hyoscyamus-niger-l-against-covid-19-a-phase-ii-multicenter-placebo-controlled-randomized-trial
#21
JOURNAL ARTICLE
Morteza Kosari, Farzin Khorvash, Mohammad Kazem Sayyah, Maryam Ansari Chaharsoughi, Ahmad Najafi, Mansooreh Momen-Heravi, Mohammad Karimian, Hossein Akbari, Mehdi Noureddini, Mahmoud Salami, Amir Ghaderi, Javad Amini Mahabadi, Seyed Peyman Khamechi, Somayeh Yeganeh, Hamid Reza Banafshe
The incubation period of COVID-19 symptoms, along with the proliferation and high transmission rate of the SARS-CoV-2 virus, is the cause of an uncontrolled epidemic worldwide. Vaccination is the front line of prevention, and antiinflammatory and antiviral drugs are the treatment of this disease. In addition, some herbal therapy approaches can be a good way to deal with this disease. The aim of this study was to evaluate the effect of propolis syrup with Hyoscyamus niger L. extract in hospitalized patients with COVID-19 with acute disease conditions in a double-blinded approach...
November 22, 2023: Phytotherapy Research: PTR
https://read.qxmd.com/read/37983128/the-frequency-and-manifestations-of-ocular-causes-of-abnormal-head-posture
#22
JOURNAL ARTICLE
Mohammad Reza Akbari, Masoud Khorrami-Nejad, Yasr Adil Shakor, Farzaneh Dehghanian Nasrabadi, Haleh Kangari, Hamid Dalvand
PURPOSE: To determine the frequency and manifestations of different ocular causes of abnormal head posture (AHP). METHOD: This prospective, consecutive case series study was performed on 149 patients with ocular AHP at Farabi hospital, Iran, from February 2020 to June 2021. All patients underwent routine ophthalmic examinations. The manifestation of AHP was determined by direct observation from three viewing angles, while the patient read the smallest line on the vision chart that they could see...
November 20, 2023: Journal of Binocular Vision and Ocular Motility
https://read.qxmd.com/read/37980504/sars-cov-2-helicase-might-interfere-with-cellular-nonsense-mediated-rna-decay-insights-from-a-bioinformatics-study
#23
JOURNAL ARTICLE
Behnia Akbari, Ehsan Ahmadi, Mohammad Reza Zabihi, Mina Roshan Zamir, Mina Sadeghi Shaker, Farshid Noorbakhsh
BACKGROUND: Viruses employ diverse strategies to interfere with host defense mechanisms, including the production of proteins that mimic or resemble host proteins. This study aimed to analyze the similarities between SARS-CoV-2 and human proteins, investigate their impact on virus-host interactions, and elucidate underlying mechanisms. RESULTS: Comparing the proteins of SARS-CoV-2 with human and mammalian proteins revealed sequence and structural similarities between viral helicase with human UPF1...
November 18, 2023: BMC genomic data
https://read.qxmd.com/read/37943872/a-single-nucleotide-polymorphism-in-the-aldh2-gene-modifies-the-risk-of-esophageal-squamous-cell-carcinoma-in-brca2-p-k3326-carriers
#24
JOURNAL ARTICLE
Neda Zamani, Agata Szymiczek, Ramin Shakeri, Hossein Poustchi, Akram Pourshams, Steven Narod, Reza Malekzadeh, Mohammad R Akbari
Esophageal squamous cell carcinoma (ESCC) has a very high incidence rate in northeastern Iran. Our team previously reported the BReast CAncer gene 2 (BRCA2) p.K3326* mutation as a moderately penetrant ESCC susceptibility variant in northern Iran (odds ratio (OR) = 3.64, 95% confidence interval (CI) = 1.74-7.59, P = 0.0003). Recently, it has been reported that aldehydes can induce BRCA2 haploinsufficiency in cells with a heterozygous pathogenic BRCA2 mutation and predispose them to carcinogenic effects. Based on this observation, we speculate that dysfunctional variants in Aldehyde Dehydrogenase 2 Family Member (ALDH2) may result in aldehyde-induced BRCA2 haploinsufficiency and increase cancer risk in BRCA2 mutation carriers...
2023: PloS One
https://read.qxmd.com/read/37919464/the-effect-of-ganoderma-lucidum-polysaccharide-extract-on-sensitizing-prostate-cancer-cells-to-flutamide-and-docetaxel-an-in-vitro-study
#25
JOURNAL ARTICLE
Ramin Rahimnia, Mohmammad Reza Akbari, Alimohammad Fakhr Yasseri, Diana Taheri, Akram Mirzaei, Helia Azodian Ghajar, Parmida Dehghanpoor Farashah, Leila Zareian Baghdadabad, Seyed Mohammad Kazem Aghamir
Ganoderma lucidum polysaccharide is the most widely used complementary therapy in cancer. The present study aims to investigate the possible interaction between Ganoderma lucidum polysaccharide and Docetaxel (a chemotherapy drug) and the first-line medication for prostate cancer treatment (Flutamide) and sensitizing the cells to these treatments. The cytotoxic effects of Ganoderma lucidum polysaccharide in combination with Docetaxel and Flutamide on prostate cancer cells were investigated by the MTT test, Hoechst staining, and flow cytometry...
November 2, 2023: Scientific Reports
https://read.qxmd.com/read/37915327/a-human-pilot-study-on-positive-electrostatic-charge-effects-in-solid-tumors-of-the-late-stage-metastatic-patients
#26
JOURNAL ARTICLE
Ashkan Zandi, Fatemeh Shojaeian, Fereshteh Abbasvandi, Mohammad Faranoush, Robab Anbiaee, Parisa Hoseinpour, Ali Gilani, Mohammad Saghafi, Afsoon Zandi, Meisam Hoseinyazdi, Zahra Davari, Seyyed Hossein Miraghaie, Mahtab Tayebi, Morteza Sanei Taheri, S Mehdi Samimi Ardestani, Zahra Sheikhi Mobarakeh, Mohammad Reza Nikshoar, Mohammad Hossein Enjavi, Yasin Kordehlachin, S M Sadegh Mousavi-Kiasary, Amir Mamdouh, Mohammad Esmaeil Akbari, Masud Yunesian, Mohammad Abdolahad
BACKGROUND: Correlative interactions between electrical charges and cancer cells involve important unknown factors in cancer diagnosis and treatment. We previously reported the intrinsic suppressive effects of pure positive electrostatic charges (PEC) on the proliferation and metabolism of invasive cancer cells without any effect on normal cells in cell lines and animal models. The proposed mechanism was the suppression of pro-caspases 3 and 9 with an increase in Bax/Bcl2 ratio in exposed malignant cells and perturbation induced in the KRAS pathway of malignant cells by electrostatic charges due to the phosphate molecule electrostatic charge as the trigger of the pathway...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37878050/the-induction-of-tau-aggregation-is-restricted-by-sulfamethoxazole-and-provides-new-information-regarding-the-use-of-the-drug
#27
JOURNAL ARTICLE
Vali Akbari, Seifollah Bahramikia, Ali R Jalalvand, Masomeh Mehrabi, Mohammad Ezati, Reza Khodarahmi
The aggregation of tau protein in the form of paired helical filament (PHF) leads to the breakdown of microtubule structure and the development of neurodegenerative disorders, such as Alzheimer's disease. Therefore, inhibiting tau protein aggregation is a potential strategy for preventing the progression of these disorders. In this study, sulfamethoxazole (SMZ), an antibiotic that easily crosses the blood-brain barrier and interacts with tau protein, was tested for its ability to inhibit tau aggregation in vitro ...
October 25, 2023: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/37877425/recent-advances-in-functional-cellulose-based-films-with-antimicrobial-and-antioxidant-properties-for-food-packaging
#28
REVIEW
Yihan Shen, Farzad Seidi, Mehraj Ahmad, Yuqian Liu, Mohammad Reza Saeb, Ali Akbari, Huining Xiao
The packaging of food plays a crucial role in food preservation worldwide. However, traditional packaging systems are passive layers with weak efficiency in protecting the food quality. Therefore, packaged foods are gradually spoiled due to the oxidation and growth of microorganisms. Additionally, most of the commercial packaging films are made of petroleum-based materials which raise environmental concerns. Accordingly, the development of eco-friendly natural-derived active packaging systems has increased the attention of scientists...
October 25, 2023: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/37876013/crosstalk-between-autophagy-and-insulin-resistance-evidence-from-different-tissues
#29
REVIEW
Asie Sadeghi, Maryam Niknam, Mohammad Amin Momeni-Moghaddam, Maryam Shabani, Hamid Aria, Alireza Bastin, Maryam Teimouri, Reza Meshkani, Hamed Akbari
Insulin is a critical hormone that promotes energy storage in various tissues, as well as anabolic functions. Insulin resistance significantly reduces these responses, resulting in pathological conditions, such as obesity and type 2 diabetes mellitus (T2DM). The management of insulin resistance requires better knowledge of its pathophysiological mechanisms to prevent secondary complications, such as cardiovascular diseases (CVDs). Recent evidence regarding the etiological mechanisms behind insulin resistance emphasizes the role of energy imbalance and neurohormonal dysregulation, both of which are closely regulated by autophagy...
October 25, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37869695/safety-and-health-management-system-safety-climate-and-accident-occurrences-in-hospitals-the-study-of-needlestick-sharp-injuries-and-recidivism-rates
#30
JOURNAL ARTICLE
Jafar Akbari, Ahmad Ghadami, Mohammad Reza Taheri, Nasrin Khosravi, Shirin Zamani
BACKGROUND: Hospital Safety and Health Management System (HSH-MS) and Hospital Safety Climate (HSC) are the significant elements to develop safe work practices. The current study aimed to examine the dimensions of HSH-MS and HSC and the association with the prevalence of Needlestick and Sharp Injury (NSI) and NSI recidivism. MATERIALS AND METHODS: A cross-sectional study was conducted among 1070 nurses in Iranian hospitals (89% response rate). RESULTS: More than 54% ( n = 579) had sustained at least 1 NSI in the previous year...
2023: Iranian Journal of Nursing and Midwifery Research
https://read.qxmd.com/read/37856972/reconstruction-of-a-lateral-thigh-defect-with-a-transverse-rectus-abdominis-myocutaneous-tram-free-flap-a-case-report
#31
Mojtaba Ghavidel, Mohammad Reza Akhondinasab, Mehdi Karami, Hossein Akbari, Shokoufe Mortazavi, Yousef Shafaei
INTRODUCTION: Despite advancements in reconstructive surgery, the repair of large thigh deformities remains challenging. When other options are not feasible, distant flaps become necessary. Successful repairs have been achieved using a transverse rectus abdominis myocutaneous (TRAM) flap for the chest wall, groin, abdominal wall, sternum, and breast. CASE PRESENTATION: This study presents the case of a 40-year-old man who experienced a large deformity, measuring 20 cm ∗ 10 cm in his left lateral thigh resulting from a road accident that occurred a decade ago...
September 16, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37822183/toward-facial-rejuvenation-a-clinical-trial-to-assess-the-efficacy-of-nano-fat-grafting-on-wrinkles
#32
JOURNAL ARTICLE
Farzaneh Akbari, Maryam Hadibarhaghtalab, Seyedeh Yasamin Parvar, Sara Dehghani, Mohammad Reza Namazi
INTRODUCTION: With increasing age, patients' facial volume decrease. For this reason, nano fat grafting has recently gained popularity as adjunctive treatment to facial rejuvenation procedures. However, few quantitative studies have been conducted to investigate the impact of nano fat on facial wrinkles. AIMS: In the present study, authors aim to investigate the therapeutic effect of intradermal injection of nano fat on fine facial wrinkles and assess their changes over 7 months of follow-up...
October 11, 2023: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/37783312/comparing-the-association-between-heavy-metals-and-cognitive-status-and-depression-in-miners-and-non-miners-a-study-from-southeast-of-iran
#33
JOURNAL ARTICLE
Narjes Soltani, Tabandeh Sadeghi, Parvin Khalili, Mohammad Reza Mahmoodi, Majid Saadloo, Mohammad Reza Baneshi, Soghra Akbari Chermahini, Ali Shamsizade
Heavy metal toxicity is a major public health crisis worldwide, especially in mining environments. The association between chronic heavy metals exposure and cognitive impairment has not been studied broadly in adults and mining fields. This study aimed to compare the association between arsenic (As), lead (Pb), and copper (Cu) concentration in blood and cognitive status and depression in copper miners and non-miners. Participants were selected from the Rafsanjan cohort study (RCS) as non-miners and miners from Sarcheshmeh Copper Complex...
December 2023: Neurotoxicology
https://read.qxmd.com/read/37736513/evaluation-of-the-expression-profile-of-mrnas-and-lncrnas-in-cumulus-cells-associated-with-polycystic-ovary-syndrome-and-pregnancy
#34
JOURNAL ARTICLE
Behnaz Hammami, Fatemeh Sadat Mostafavi, Ali Akbari, Seyyed Reza Mousavi, Mohammad Kazemi
OBJECTIVES: Polycystic ovary syndrome (PCOS), the primary cause of anovulatory infertility in women, may change the gene expression profile of cumulus cells. In human ART (assisted reproductive technology), gene expression profiling in cumulus cells, a non-invasive method, may be used to identify the most competent oocytes. We aim to identify key genes according to the network-based data and assess the suitability of these genes as markers to predict oocyte competence and PCOS diagnosis...
2023: Iranian Journal of Basic Medical Sciences
https://read.qxmd.com/read/37724146/anti-cancer-effect-of-dorema-ammoniacum-gum-by-targeting-metabolic-reprogramming-by-regulating-apc-p53-kras-gene-expression-in-ht-29-human-colon-cancer-cells
#35
JOURNAL ARTICLE
Elham Ghodousi-Dehnavi, Mohammad Arjmand, Ziba Akbari, Mansour Aminzadeh, Reza Haji Hosseini
BACKGROUND: Colorectal cancer is a heterogeneous disease that leads to metabolic disorders due to multiple upstream genetic and molecular changes and interactions. The development of new therapies, especially herbal medicines, has received much global attention. Dorema ammoniacum is a medicinal plant. Its gum is used in healing known ailments. Studying metabolome profiles based on nuclear magnetic resonance 1HNMR as a non-invasive and reproducible tool can identify metabolic changes as a reflection of intracellular fluxes, especially in drug responses...
April 2023: Reports of Biochemistry & Molecular Biology
https://read.qxmd.com/read/37685083/inactivation-of-foodborne-pathogens-by-lactiplantibacillus-strains-during-meat-fermentation-kinetics-and-mathematical-modelling
#36
JOURNAL ARTICLE
Seyed Mohammad Bagher Hashemi, Reza Roohi, Masoud Akbari, Alessandra Di Natale, Francesca Conte
This study examined the effect of beef fermentation with Lactiplantibacillus paraplantarum ( L ) PTCC 1965, Lactiplantibacillus ( L ) plantarum subsp. plantarum PTCC 1745, and Lactiplantibacillus ( L ) pentosus PTCC 1872 bacteria on the growth of pathogenic bacteria, including Salmonella (S) Typhi PTCC 1609 and Staphylococcus ( S ) aureus PTCC 1826. The growth of lactic acid bacteria (LAB) and the effect of fermentation on pathogenic bacteria were studied using Weibull: biphasic linear and competitive models...
August 22, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/37668767/correction-to-high-genetic-heterogeneity-of-leukodystrophies-in-iranian-children-the-first-report-of-iranian-leukodystrophy-registry
#37
Mahmoudreza Ashrafi, Reyhaneh Kameli, Sareh Hosseinpour, Ehsan Razmara, Zahra Zamani, Zahra Rezaei, Raziyeh Mashayekhi, Neda Pak, Mohammad Barzegar, Reza Azizimalamiri, Morteza Rezvani Kashani, Nahideh Khosroshahi, Maryam Rasulinezhad, Morteza Heidari, Man Amanat, Alireza Abdi, Bahram Mohammadi, Mahmoud Mohammadi, Gholam Reza Zamani, Reza Shervin Badv, Abdolmajid Omrani, Sedigheh Nikbakht, Ali Hosseini Bereshneh, Mojtaba Movahedinia, Hossein Farshad Moghaddam, Hossein Shojaaldini Ardakani, Masood Ghahvechi Akbari, Mehran Beiraghi Tousi, Mohammad Vafaee Shahi, Firouzeh Hosseini, Masoud Hassanvand Amouzadeh, Seyed Ahmad Hosseini, Ali Nikkhah, Ali Khajeh, Hooman Alizadeh, Bahram Yarali, Mohammad Rohani, Parviz Karimi, Hadi Montazer Lotf Elahi, Seyyed Mohamad Mahdi Hosseiny, Masoumeh Sadat Sadeghzadeh, Hossein Mohebbi, Maryam Hosseini Moghadam, Hajar Aryan, Hassan Vahidnezhad, Mahdieh Soveizi, Bahareh Rabbani, Ali Rabbani, Nejat Mahdieh, Masoud Garshasbi, Ali Reza Tavasoli
No abstract text is available yet for this article.
September 5, 2023: Neurogenetics
https://read.qxmd.com/read/37663381/the-antidepressant-effect-of-combined-extracts-of-hypericum-perforatum-and-echium-amoenum-supplementation-in-patients-with-depression-symptoms-a-randomized-clinical-trial
#38
JOURNAL ARTICLE
Akram Sadeghi, Fatemeh Ghorayshi, Hojjat Baghshahi, Hossein Akbari, Mohammad Reza Memarzadeh, Mohsen Taghizadeh, Alireza Safaei
OBJECTIVE: Echium amoenum and Hypericum perforatum dried flowers have been used for therapy of mental disorders in Iranian traditional medicine. In this study, we assessed the efficacy of the E. amoenum and H. perforatum extracts in patients with mild to moderate depression. MATERIALS AND METHODS: In an 8-week double-blind, parallel-group trial, 51 patients randomly consumed 20 mg of fluoxetine or 350 mg of herbal medicine twice daily. The Hamilton Rating Scale for Depression (HAM-D) was used to assess depression severity in patients at weeks 0, 4, and 8...
2023: Avicenna Journal of Phytomedicine
https://read.qxmd.com/read/37597066/high-genetic-heterogeneity-of-leukodystrophies-in-iranian-children-the-first-report-of-iranian-leukodystrophy-registry
#39
JOURNAL ARTICLE
Mahmoudreza Ashrafi, Reyhaneh Kameli, Sareh Hosseinpour, Ehsan Razmara, Zahra Zamani, Zahra Rezaei, Raziyeh Mashayekhi, Neda Pak, Mohammad Barzegar, Reza Azizimalamiri, Morteza Rezvani Kashani, Nahideh Khosroshahi, Maryam Rasulinezhad, Morteza Heidari, Man Amanat, Alireza Abdi, Bahram Mohammadi, Mahmoud Mohammadi, Gholam Reza Zamani, Reza Shervin Badv, Abdolmajid Omrani, Sedigheh Nikbakht, Ali Hosseini Bereshneh, Mojtaba Movahedinia, Hossein Farshad Moghaddam, Hossein Shojaaldini Ardakani, Masood Ghahvechi Akbari, Mehran Beiraghi Tousi, Mohammad Vafaee Shahi, Firouzeh Hosseini, Masoud Hassanvand Amouzadeh, Seyed Ahmad Hosseini, Ali Nikkhah, Ali Khajeh, Hooman Alizadeh, Bahram Yarali, Mohammad Rohani, Parviz Karimi, Hadi Montazer Lotf Elahi, Seyyed Mohamad Mahdi Hosseiny, Masoumeh Sadat Sadeghzadeh, Hossein Mohebbi, Maryam Hosseini Moghadam, Hajar Aryan, Hassan Vahidnezhad, Mahdieh Soveizi, Bahareh Rabbani, Ali Rabbani, Nejat Mahdieh, Masoud Garshasbi, Ali Reza Tavasoli
Leukodystrophies (LDs) are a heterogeneous group of progressive neurological disorders and characterized by primary involvement of white matter of the central nervous system (CNS). This is the first report of the Iranian LD Registry database to describe the clinical, radiological, and genomic data of Persian patients with leukodystrophies. From 2016 to 2019, patients suspicious of LDs were examined followed by a brain magnetic resonance imaging (MRI). A single gene testing or whole-exome sequencing (WES) was used depending on the neuroradiologic phenotypes...
August 19, 2023: Neurogenetics
https://read.qxmd.com/read/37543939/neurologic-manifestations-of-coronavirus-disease-2019-in-children-an-iranian-hospital-based-study
#40
JOURNAL ARTICLE
Elmira Haji Esmaeil Memar, Morteza Heidari, Homa Ghabeli, Elham Pourbakhtyaran, Roya Haghighi, Seyyed Mohammad Mahdi Hosseiny, Setareh Mamishi, Shima Mahmoudi, Hamid Eshaghi, Ali Reza Tavasoli, Mahmoud Mohammadi, Reza Shervin Badv, Gholamreza Zamani, Masood Ghahvehchi Akbari, Bahram Yarali, Rohola Shirzadi, Masoud Mohammadpour, Bahareh Yaghmaei, Meisam Sharifzadeh Ekbatani, Zeynab Najafi, Mahmoud Reza Ashrafi
BACKGROUND: COVID-19 infection and its neurological manifestations were seen in children although less common than adults. The aim of this study was to determine the frequency of different types of neurologic findings of hospitalized children with COVID-19. ]. METHODS: This retrospective study was performed on hospitalized pediatric patients aged≤18 years with confirmed SARS-CoV-2 at Children's Medical Center Hospital. Neurological manifestations were defined as the presence of any of the following symptoms: seizure, altered mental status, behavioral/personality change, ataxia, stroke, muscle weakness, smell and taste dysfunctions, and focal neurological disorders...
March 1, 2023: Archives of Iranian Medicine
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