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Mohammad Reza Akbari

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https://www.readbyqxmd.com/read/28430010/prolonged-injectable-formulation-of-nafarelin-using-in-situ-gel-combination-delivery-system
#1
Behnoush Alizadeh, Nika Bahari Javan, Hamid Akbari Javar, Mohammad Reza Khoshayand, Farid Abedin Dorkoosh
The principal purpose of the present study was to prepare and characterize a complex drug delivery system consisting of Nafarelin- poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs) in combination with sodium alginate/poloxamer 407 in situ gel. Nafarelin loaded PHBV NPs were prepared via double emulsion solvent evaporation technique. Box-Behnken Response Surface Methodology was utilized to optimize NPs. Mean particle size, polydispersity index (PDI), entrapment efficiency (EE) and drug loading (DL) of the optimized NPs were measured...
April 21, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28407657/the-effects-of-omega-3-fatty-acids-and-vitamin-e-co-supplementation-on-indices-of-insulin-resistance-and-hormonal-parameters-in-patients-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#2
Faraneh Afshar Ebrahimi, Mansooreh Samimi, Fatemeh Foroozanfard, Mehri Jamilian, Hossein Akbari, Elham Rahmani, Shahnaz Ahmadi, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Zatollah Asemi
This study was conducted to determine the effects of omega-3 fatty acids and vitamin E co-supplementation on indices of insulin resistance and hormonal parameters in women with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was done on 68 women diagnosed with PCOS according to the Rotterdam criteria aged 18-40 years old. Participants were randomly assigned into 2 groups to receive either 1 000 mg omega-3 fatty acids from flaxseed oil containing 400 mg α-Linolenic acid plus 400 IU vitamin E supplements (n=34) or placebo (n=34) for 12 weeks...
April 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28400295/phic31-integrase-can-improve-the-efficiency-of-different-construct-designs-for-monoclonal-antibody-expression-in-cho-cells
#3
Maryam Ahmadi, Fereidoun Mahboudi, Samira Ahmadi, Saeedeh Ebadat, Fatemeh Nematpour, Mohammad Reza Akbari Eidgahi, Fatemeh Davami
OBJECTIVES: Several types of expression vectors have been used for recombinant protein expression in Chinese hamster ovary cells (CHO) which usually result in variable and unstable levels of expression. METHODS AND RESULTS: In this study, we have compared the mAb0014 expression level of single ORF/IRES vector and dual ORF vector in the presence and absence of phiC31 integrase targeting system. Both expression vectors contain an elongation factor 1α (EF1α) promoter upstream of LC and harboring an attB site...
April 9, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28367528/the-predictive-factors-of-diplopia-and-extraocular-movement-limitations-in-isolated-pure-blow-out-fracture
#4
Abolfazl Kasaee, Arash Mirmohammadsadeghi, Fatemeh Kazemnezhad, Bahram Eshraghi, Mohammad Reza Akbari
PURPOSE: To evaluate the predictive factors for development of diplopia and extraocular muscle movement (EOM) limitations in the patients with isolated pure blow-out fracture. METHODS: One hundred thirty-two patients with isolated pure blow-out fracture were included. The diagnosis was done with computed tomography scan. Possible predictive factors were analyzed with logistic regression. The cases that underwent surgery were assigned in the surgical group, and other cases were assigned in the non-surgical group...
March 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28293387/cfp10-mfc%C3%AE-2-as-a-novel-tuberculosis-vaccine-candidate-increases-immune-response-in-mouse
#5
Ali Asghar Baghani, Saman Soleimanpour, Hadi Farsiani, Arman Mosavat, Masoud Yousefi, Zahra Meshkat, Seyed Abdolrahim Rezaee, Saeid Amel Jamehdar, Mohammad Reza Akbari Eydgahi, Hamid Sadeghian, Kiarash Ghazvini
OBJECTIVES: Despite treatment with antibiotics and vaccination with BCG, tuberculosis (TB) is still considered as one of the most important public health problems in the world. Therefore, designing and producing a more effective vaccine against TB seems urgently. In this study, immunogenicity of a fusion protein which consisting or comprising CFP-10 from Mycobacterium tuberculosis and the Fc-domain of mouse IgG2a was evaluated as a novel subunit vaccine candidate against TB. MATERIALS AND METHODS: The genetic constructs were cloned in pPICZαA expression vector and recombinant vectors (pPICZαA-CFP-10: Fcγ2a and pPICZαA-CFP-10:His) were transformed into Pichia pastoris...
February 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28260609/commissioning-of-beam-shaper-applicator-for-conformal-intraoperative-electron-radiotherapy
#6
Nematollah Heidarloo, Hamid Reza Baghani, Seyed Mahmoud Reza Aghamiri, Seyed Rabi Mahdavi, Mohammad Esmail Akbari
Beam shaper is a newly designed device for beam shaping in IOERT. The aim of this study is evaluating the performance of this device for conformal IOERT and preparing it for clinical applications. Dosimetric characteristics for different combinations of energy/field size were determined by ionometric dosimetry, film dosimetry and Monte Carlo simulation. Desirable dosimetric characteristics of beam shaper make it a useful tool for conformal IOERT. Usability of Monte Carlo simulation in any clinical setup of beam shaper was demonstrated...
February 24, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28127327/accuracy-of-linear-measurements-using-cone-beam-computed-tomography-in-comparison-with-clinical-measurements
#7
Amir Reza Rokn, Kazem Hashemi, Solmaz Akbari, Mohammad Javad Kharazifard, Hamidreza Barikani, Mehrdad Panjnoosh
OBJECTIVES: This study sought to evaluate the accuracy and errors of linear measurements of mesiodistal dimensions of Kennedy Class III edentulous space using cone beam computed tomography (CBCT) in comparison with clinical measurements. MATERIALS AND METHODS: Nineteen Kennedy Class III dental arches were evaluated. An impression was made of each dental arch and poured with dental stone. The distance was measured on dental cast using a digital Vernier caliper with an accuracy of 0...
September 2016: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28112985/comparison-of-human-amniotic-chorionic-and-umbilical-cord-multipotent-mesenchymal-stem-cells-regarding-their-capacity-for-differentiation-toward-female-germ-cells
#8
Hamid Reza Asgari, Mohammad Akbari, Hossein Yazdekhasti, Zahra Rajabi, Shadan Navid, Fereshte Aliakbari, Niloufar Abbasi, Freidon Sargolzaei Aval, Alireza Shams, Mehdi Abbasi
Placenta harbors a plentiful source of various cells with stem cells or stem-like cell properties, which can be used in therapeutic procedures and research. Mesenchymal stem cells (MSCs) have attracted much attention due to their specific differentiation potential and tolerogenic properties. MSCs have been isolated from different parts of placenta; however, in this study, we isolated MSCs from amnion and chorion membrane, as well as umbilical cord (Wharton's jelly [WJ]) and compared their capacity regarding differentiation toward female germ cells under influence of 10 ng/mL BMP4...
February 2017: Cellular Reprogramming
https://www.readbyqxmd.com/read/27957466/bed-capacity-planning-using-stochastic-simulation-approach-in-cardiac-surgery-department-of-teaching-hospitals-tehran-iran
#9
Amin Torabipour, Hojjat Zeraati, Mohammad Arab, Arash Rashidian, Ali Akbari Sari, Mahmuod Reza Sarzaiem
BACKGROUND: To determine the hospital required beds using stochastic simulation approach in cardiac surgery departments. METHODS: This study was performed from Mar 2011 to Jul 2012 in three phases: First, collection data from 649 patients in cardiac surgery departments of two large teaching hospitals (in Tehran, Iran). Second, statistical analysis and formulate a multivariate linier regression model to determine factors that affect patient's length of stay. Third, develop a stochastic simulation system (from admission to discharge) based on key parameters to estimate required bed capacity...
September 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27895857/frequency-of-vana-vanb-and-vanh-variants-amongst-vancomycin-resistant-enterococci-isolated-from-patients-in-central-region-of-iran
#10
Jaafar Rezvani, Reza Nasr, Fatemeh T Shamsabadi, Mohammad Reza Akbari Eidgahi
AIM: The aim of this study was to investigate the VRE frequency and the rate of each gene in isolated enterococci from patients with intestinal infection in the central region of Iran. BACKGROUND: Enterococci infections are a public health growing concern due to the glycopeptide antibiotics resistance especially vancomycin. Genes, vanA, B, and H contribute to the influence of vancomycin-resistant enterococci (VRE). PATIENTS AND METHODS: This study was conducted from January to July 2014 in Shahrood university hospital...
2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/27895739/gene-expression-profiling-of-the-8q22-24-position-in-human-breast-cancer-tspyl5-mtdh-atad2-and-ccne2-genes-are-implicated-in-oncogenesis-while-wisp1-and-ext1-genes-may-predict-a-risk-of-metastasis
#11
Afsoon Taghavi, Mohammad Esmaeil Akbari, Mohammad Hashemi-Bahremani, Nahid Nafissi, Ahad Khalilnezhad, Seyed Mohammad Poorhosseini, Feyzollah Hashemi-Gorji, Vahid Reza Yassaee
Gene expression profiling has been suggested to predict breast cancer outcome. The prognostic value of the 8q22-24 position in breast cancer remains to be elucidated. The present study evaluated expression patterns of the genes located at this position in metastatic and non-metastatic breast cancer. A total of 85 patients with recurrent/metastatic (n=15) and non-metastatic (n=70) early-stage, estrogen receptor-positive and lymph node-negative breast tumors were included. In addition, 15 normal breast tissue samples were used as controls...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27881297/a-randomized-controlled-clinical-trial-investigating-the-effects-of-omega-3-fatty-acids-and-vitamin-e-co-supplementation-on-biomarkers-of-oxidative-stress-inflammation-and-pregnancy-outcomes-in-gestational-diabetes
#12
Mehri Jamilian, Shahrzad Hashemi Dizaji, Fereshteh Bahmani, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Maryam Karamali, Maryam Akbari, Zatollah Asemi
OBJECTIVES: Limited data are available for assessing the effects of omega-3 fatty acids and vitamin E co-supplementation on metabolic profiles and pregnancy outcomes in gestational diabetes (GDM). This study was designed to determine the effects of omega-3 fatty acids and vitamin E co-supplementation on biomarkers of oxidative stress, inflammation and pregnancy outcomes in women with GDM. METHODS: This randomized, double-blind, placebo-controlled clinical trial was conducted in 60 patients with GDM who were not taking oral hypoglycemic agents...
November 21, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27833445/cloning-and-expression-of-aca-f-1-a-new-allergen-of-acacia-farnesiana-pollen
#13
Gholam Reza Khosravi, Mohammad-Ali Assarehzadegan, Payam Morakabati, Bahareh Akbari, Fatemeh Dousti
Acacia farnesiana is the main source of allergenic pollen and one of the most important causes of respiratory allergic disease in tropical and subtropical regions of the world. The purpose of this study was to produce a recombinant variety of allergenic Ole e 1-like protein from the pollen of this tree. To predict its allergenic cross-reactivity with other members of the Ole e 1-like protein family of common allergenic plants, the nucleotide sequence homology of the Acacia Ole e 1-like protein was evaluated...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27797255/effects-of-smoking-on-cost-of-hospitalization-and-length-of-stay-among-patients-with-lung-cancer-in-iran-a-hospital-based-study
#14
Ali Akbari Sari, Satar Rezaei, Mohammad Arab, Reza Majdzadeh, Behzad Karami Matin, Hamed Zandian
BACKGROUND: Smoking is recognized as a main leading preventable cause of mortality and morbidity worldwide. It is responsible for a considerable nancial burden both on the health system and in society. This study aimed to examine the effect of smoking on cost of hospitalization and length of stay (LoS) among patients with lung cancer in Iran in 2014. MATERIALS AND METHODS: A total of 415 patients were included in the study. Data on age, sex, insurance status, type of hospitals, type of insurance, geographic local, length of stay and cost of hospitalization was extracted by medical records and smoking status was obtained from a telephone survey...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27660426/sex-differences-in-stroke-a-socioeconomic-perspective
#15
Ahmad Delbari, Farzane Keyghobadi, Yadollah Abolfathi Momtaz, Fariba Keyghobadi, Reza Akbari, Houman Kamranian, Mohammad Shouride Yazdi, Sayed Shahaboddin Tabatabaei, Seyed-Mohammad Fereshtehnejad
BACKGROUND: A number of studies have explored the issue of sex differences in stroke from biomedical perspective; however, there are still large gaps in the existing knowledge. The purpose of this study was to assess whether the differences in socioeconomic status and living conditions between men and women may explain the part of the sex differences in incidence and outcomes of stroke. METHODS: All stroke participants aged ≥60 years admitted in Vaseie Hospital in Sabzevar, Iran, from March 21, 2013, until March 20, 2014, were included in this study...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27644605/survivin-a-promising-gene-for-targeted-cancer-treatment
#16
REVIEW
Fatemeh T Shamsabadi, Mohammad Reza Akbari Eidgahi, Parvaneh Mehrbod, Nasibeh Daneshvar, Zeenathul Nazariah Allaudin, Ahad Yamchi, Majid Shahbazi
Drawbacks of conventional cancer treatments, with lack of specificity and cytotoxicity using current approaches, underlies the necessity for development of a novel approach, gene-directed cancer therapy. This has provided novel technological opportunities in vitro and in vivo. This review focuses on a member of an apoptosis inhibitor family, survivin, as a valuable target. Not only the gene but also its promoter are applicable in this context. This article is based on a literature survey, with especial attention to RNA interference as well as tumor- specific promoter action...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27617243/age-at-natural-menopause-and-related-factors-in-isfahan-iran
#17
Parastoo Golshiri, Mojtaba Akbari, Mohammad Reza Abdollahzadeh
OBJECTIVE: This study was aimed to evaluate the age at natural menopause and related factors among women in a population based study in 2015 in Isfahan, Islamic Republic of Iran. METHODS: In this cross-sectional study 960 menopausal women were selected by cluster sampling. Demographic, socioeconomic, lifestyle behavior and reproductive history aspects were collected using a structured questionnaire. Woman and her husband's educational level and occupation with family income were the variables to construct socioeconomic status using principal component analysis...
August 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/27604579/evaluating-the-efficiency-of-phic31-integrase-mediated-monoclonal-antibody-expression-in-cho-cells
#18
Maryam Ahmadi, Fereidoun Mahboudi, Mohammad Reza Akbari Eidgahi, Reza Nasr, Fatemeh Nematpour, Samira Ahmadi, Saeedeh Ebadat, Mojtaba Aghaeepoor, Fatemeh Davami
Traditional methods to generate CHO cell lines rely on random integration(s) of the gene of interest and result in unpredictable and unstable protein expression. In comparison, site-specific recombination methods increase the recombinant protein expression by inserting transgene at a locus with specific expression features. PhiC31 serine integrase, catalyze unidirectional integration that occurs at higher frequency in comparison with the reversible integration carried out by recombinases such as Cre. In this study, using different ratios of phiC31 serine integrase, we evaluated the phiC31 mediated gene integration for expression of a humanized IgG1 antibody (mAb0014) in CHO-S cells...
November 2016: Biotechnology Progress
https://www.readbyqxmd.com/read/27579287/economic-burden-of-smoking-a-systematic-review-of-direct-and-indirect-costs
#19
Satar Rezaei, Ali Akbari Sari, Mohammad Arab, Reza Majdzadeh, Asghar Mohammad Poorasl
BACKGROUND: Smoking imposes considerably high economic costs both on the healthcare system as well as on a country as a whole. This study was aimed at systematically reviewing the currently published literature on the direct and indirect costs associated with smoking globally. METHODS: A systematic review was performed on systematically searched articles from PubMed and Scopus databases published during the period 1990 to 2014. A combination of key terms such as "economic burden", "direct cost", "indirect cost", and smoking, tobacco or cigarette" and "productivity lost was used for the search...
2016: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/27555711/multiple-ocular-and-systemic-disorders-in-association-with-bilateral-duane-s-retraction-syndrome
#20
Mohammad Ali Zare, Mohammad Reza Akbari, Mohammad Yaser Kiarudi, Hadi Zare Mehrjardi
Duane's retraction syndrome (DRS) is characterized by limitations in horizontal eye movements, globe retraction, and palpebral fissure narrowing on attempted adduction. This disorder is caused by a disturbance in innervation originating in the brain stem and represents <1% of all cases of strabismus. It is postulated that this syndrome is due to an insult during the early weeks (8-10 weeks) of pregnancy and is 10-20 times more frequently associated with other systemic congenital anomalies. This case report of bilateral DRS included bilateral iris-retinal coloboma and congenital heart disease, sensory hearing loss, and inguinal hernia...
July 2016: Middle East African Journal of Ophthalmology
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