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Endophthalmitis Prophylaxy

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https://www.readbyqxmd.com/read/28440583/topical-antibiotics-and-intravitreal-injections
#1
REVIEW
Alex P Hunyor, Rohan Merani, Archie Darbar, Jean-François Korobelnik, Paolo Lanzetta, Annabelle A Okada
There is increasing evidence that topical antibiotics, given before and/or after intravitreal injections, are ineffective in preventing endophthalmitis and are possibly harmful. In addition to the lack of efficacy and increased development of resistant organisms, the use of topical antibiotics adds significantly to the cost of delivering intravitreal therapy. Despite this, in many countries, it is still common practice to use pre- and/or postinjection topical antibiotics. This review outlines the general principles of effective antibiotic prophylaxis, and the evidence regarding topical antibiotic use as a prophylactic measure for endophthalmitis following intravitreal injections...
April 25, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28438590/antibiotic-prophylaxis-in-cataract-surgery-in-the-setting-of-penicillin-allergy-a-decision-making-algorithm
#2
REVIEW
Benjamin R LaHood, Nicholas Andrew, Michael Goggin
Cataract surgery is the most commonly performed surgical procedure in many developed countries. Post-operative endophthalmitis is a rare complication with potentially devastating visual outcomes. Currently, there is no global consensus regarding antibiotic prophylaxis in cataract surgery despite growing evidence of the benefits of prophylactic intracameral cefuroxime at the conclusion of surgery. The decision about which antibiotic regimen to use is further complicated in patients reporting penicillin allergy...
April 21, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28328861/relationship-between-anesthesia-and-postoperative-endophthalmitis-a-retrospective-study
#3
Hou-Chuan Lai, Wei-Cheng Tseng, Shu-I Pao, Chih-Shung Wong, Ren-Chih Huang, Wei-Hung Chan, Zhi-Fu Wu
Previous study showed that patients under general anesthesia (GA) had nasopharyngeal secretions on the face at the end of ocular surgery, especially in propofol-based total intravenous anesthesia (TIVA), it might induce postoperative endophthalmitis. Therefore, we conducted a retrospective study to compare the incidence of endophthalmitis after ocular surgery under topical, inhalation anesthesia, and propofol-based TIVA in our medical center from 2011 to 2015.A total of 21,032 patients were included, and we evaluated epidemiologic factors, systemic diseases, other ocular pathologic characteristics, complications during the surgery, technique of ocular surgery, method of antibiotic prophylaxis, vitreous culture, and vision outcome in these patients...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28267115/pooled-estimates-of-incidence-of-endophthalmitis-after-intravitreal-injection-of-anti-vascular-endothelial-growth-factor-agents-with-and-without-topical-antibiotic-prophylaxis
#4
Michele Reibaldi, Alfredo Pulvirenti, Teresio Avitabile, Vincenza Bonfiglio, Andrea Russo, Cesare Mariotti, Claudio Bucolo, Rodolfo Mastropasqua, Guglielmo Parisi, Antonio Longo
PURPOSE: To assess the effect of topical antibiotic prophylaxis on postoperative endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents. METHODS: A systematic literature search was performed from inception to March 2016 using PubMed, Medline, Web of Science, Embase, and the Cochrane Library, to identify articles that reported cases of endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents...
March 6, 2017: Retina
https://www.readbyqxmd.com/read/28214101/endophthalmitis-reduction-with-intracameral-moxifloxacin-prophylaxis-analysis-of-600%C3%A2-000-surgeries
#5
Aravind Haripriya, David F Chang, Ravilla D Ravindran
PURPOSE: To compare the postoperative endophthalmitis rate before and after initiation of intracameral (IC) moxifloxacin prophylaxis for both phacoemulsification and sutureless, manual small-incision cataract surgery (M-SICS), as well as in patients with posterior capsular rupture (PCR). DESIGN: Retrospective, clinical registry. PARTICIPANTS: All cataract surgeries (617 453) performed during the 29-month period from January 2014 to May 2016 at the 10 regional Aravind eye hospitals were included...
February 14, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28192644/perioperative-antibiotics-for-prevention-of-acute-endophthalmitis-after-cataract-surgery
#6
REVIEW
Emily W Gower, Kristina Lindsley, Samantha E Tulenko, Afshan A Nanji, Ilya Leyngold, Peter J McDonnell
BACKGROUND: Endophthalmitis is a severe inflammation of the anterior or posterior (or both) chambers of the eye that may be sterile or associated with infection. It is a potentially vision-threatening complication of cataract surgery. Prophylactic measures for endophthalmitis are targeted against various sources of infection. OBJECTIVES: To evaluate the effects of perioperative antibiotic prophylaxis for endophthalmitis following cataract surgery compared with no prophylaxis or other form of prophylaxis...
February 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28013528/pathogens-and-antibiotic-sensitivities-in-endophthalmitis
#7
Geraldine R Slean, Neal H Shorstein, Liyan Liu, John F Paschal, Kevin L Winthrop, Lisa J Herrinton
BACKGROUND: Antibiotic prophylaxis in cataract surgery is intended to minimize endophthalmitis. We describe pathogenic organisms, antibiotic sensitivities and antibiotic prophylaxis in culture-proven endophthalmitis cases. DESIGN: Retrospective consecutive case series and community-based setting were used. PARTICIPANTS: Two hundred fifteen cases of endophthalmitis after cataract surgery performed during 2007-2012 in Kaiser Permanente, California...
December 25, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28007117/anaphylactic-reaction-secondary-to-topical-preoperative-moxifloxacin
#8
Michael A Ullman, Kirsten J Midgley, Jocelyn Kim, Saul Ullman
We report a case of anaphylactic shock following topical administration of moxifloxacin for endophthalmitis prophylaxis prior to cataract surgery. Immunoglobulin E (IgE) serology and IgE skin testing confirmed the anaphylactic etiology. Phacoemulsification with posterior chamber intraocular lens implantation was later performed with identical preoperative preparation except for the exclusion of moxifloxacin; no anaphylactic response occurred. To our knowledge, this is the first report of an anaphylactic response to topical moxifloxacin...
December 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28007104/dose-and-administration-of-intracameral-moxifloxacin-for-prophylaxis-of-postoperative-endophthalmitis
#9
Steve A Arshinoff, Milad Modabber
PURPOSE: To review current and past practices of intracameral antibiotic administration for infection prophylaxis in cataract surgery; to review the benefits and liabilities of available prophylactic drugs, dosage determination, and administration protocols; and to devise an optimum dose and administration protocol for intracameral moxifloxacin. SETTING: Humber River Hospital and the University of Toronto, Toronto, Ontario, Canada. DESIGN: Retrospective evaluation of treatment modality...
December 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27981903/endophthalmitis-prophylaxis-in-cataract-surgery-overview-of-current-practice-patterns-around-the-world
#10
Andrzej Grzybowski, Stephen G Schwartz, Kazuki Matsuura, Stephan O Tone, Steve Arshinoff, Jonathon Q Ng, Jay J Meyer, Wu Liu, Soosan Jacob, Mark Packer, Rifna Lutfiamida, Sjakon Tahija, Paul Roux, Boris Malyugin, Julio A Urrets-Zavalia, Nicolas Crim, Evangelina Esposito, Pablo Daponte, Fernando Pellegrino, Enrique O Graue-Hernandez, Aida Jimenez-Corona, Jorge E Valdez-Garcia, Julio C Hernandez-Camarena, Nidhi Relhan, Harry W Flynn, Ravilla D Ravindran, Anders Behnding
BACKGROUND: Acute-onset postoperative endophthalmitis after cataract surgery remains a rare but important cause of visual loss. There is no global consensus regarding the optimal strategies for prophylaxis of endophthalmitis and practices vary substantially around the world, especially with respect to the use of intracameral antibiotics. The European Society of Cataract & Refractive Surgeons in a randomized clinical trial (2007) reported an approximately 5-fold reduction in endophthalmitis rates associated with the use of intracameral cefuroxime...
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27956296/postoperative-hemorrhagic-occlusive-retinal-vasculitis-associated-with-intracameral-vancomycin-prophylaxis-during%C3%A2-cataract-surgery
#11
Matthew A Miller, Lucas T Lenci, Chittaranjan V Reddy, Stephen R Russell
We present the case of a 75-year-old man who had uneventful cataract surgery and administration of intracameral vancomycin for endophthalmitis prophylaxis, followed by the same procedure in the fellow eye 1 week later. The patient subsequently developed bilateral hemorrhagic occlusive retinal vasculitis, resulting in profound vision loss in both eyes. A second case of hemorrhagic occlusive retinal vasculitis previously reported from our institution is summarized. That case was characterized by a far milder course, with rapid resolution of vision loss...
November 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27933222/endophthalmitis-prophylaxis-using-a-single-drop-of-thermoresponsive-controlled-release-microspheres-loaded-with-moxifloxacin-in-a-rabbit-model
#12
Alex Mammen, Eric G Romanowski, Morgan V Fedorchak, Deepinder K Dhaliwal, R M Shanks, Regis P Kowalski
PURPOSE: Postsurgical endophthalmitis is a sight-threatening problem. We introduce a simple approach by using a single application of thermoresponsive controlled-release microspheres, loaded with moxifloxacin, to prevent bacterial endophthalmitis in a rabbit endophthalmitis prevention model. METHODS: We separated 24 rabbits into 3 treatment groups in which topical drop treatment was placed onto the conjunctival cul-de-sac: (1) a single drop of controlled-release microspheres containing moxifloxacin, (2) a single drop of controlled-release microspheres without moxifloxacin, and (3) multiple topical treatment with moxifloxacin alone every 15 minutes for 1 hour...
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27822008/an-updated-estimate-of-costs-of-endophthalmitis-following-cataract-surgery-among-medicare-patients-2010-2014
#13
Jordana K Schmier, Carolyn K Hulme-Lowe, David W Covert, Edmund C Lau
BACKGROUND: Endophthalmitis, which can occur after ophthalmic surgery, is an inflammation of the intraocular cavity and causes temporary or permanent vision impairment. However, little is known about the cost of treatment. The objective of this analysis was to update and expand upon the results of a previously published report that estimated the direct medical cost of treatment for endophthalmitis. METHODS: Retrospective data analysis using 2010 through 2014 United States Medicare Limited Data Sets...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27817919/incidence-and-outcomes-of-positive-donor-corneoscleral-rim-fungal-cultures-after-keratoplasty
#14
Jesse M Vislisel, Kenneth M Goins, Michael D Wagoner, Gregory A Schmidt, Benjamin T Aldrich, Jessica M Skeie, Cynthia R Reed, M Bridget Zimmerman, Mark A Greiner
PURPOSE: To determine the incidence of positive corneoscleral donor rim fungal cultures after keratoplasty and to report clinical outcomes of grafts with culture-positive donor rims. DESIGN: Retrospective cohort study. PARTICIPANTS: Consecutive donor corneas and keratoplasty recipients at a single tertiary referral center over 20 years. METHODS: Patient charts were reviewed to determine the incidence of positive donor rim fungal cultures and clinical outcomes of all grafts using contaminated tissue...
January 2017: Ophthalmology
https://www.readbyqxmd.com/read/27793818/randomised-controlled-trial-of-prophylactic-antibiotic-treatment-for-the-prevention-of-endophthalmitis-after-open-globe-injury-at-groote-schuur-hospital
#15
N Du Toit, S Mustak, C Cook
BACKGROUND/AIMS: Most post-traumatic acute infectious endophthalmitis occur within a week of open globe trauma, necessitating early antibiotic prophylaxis. There are few randomised studies that demonstrate the benefits of prophylactic antibiotics. This randomised controlled non-inferiority trial was aimed at determining the incidence of post-traumatic endophthalmitis using established intravenous/oral prophylaxis and comparing this to the incidence using oral antibiotics only. METHODS: All adult patients admitted with open globe injury were included...
October 28, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27720552/aqueous-chlorhexidine-for-intravitreal-injection-antisepsis-a-case-series-and-review-of-the-literature
#16
Rohan Merani, Zachary E McPherson, Alan P Luckie, Jagjit S Gilhotra, Jim Runciman, Shane Durkin, James Muecke, Mark Donaldson, Albert Aralar, Anupam Rao, Peter E Davies
PURPOSE: To determine the incidence of endophthalmitis in a large clinical series using aqueous chlorhexidine for antisepsis before intravitreal injection and to review the ophthalmic literature regarding chlorhexidine efficacy and safety. DESIGN: Multicenter retrospective case series. PARTICIPANTS: All patients receiving intravitreal injections from 7 retinal specialists. METHODS: An audit of intravitreal injections performed by retinal specialists who exclusively used aqueous chlorhexidine 0...
December 2016: Ophthalmology
https://www.readbyqxmd.com/read/27697250/endophthalmitis-after-cataract-surgery-despite-intracameral-antibiotic-prophylaxis-with-licensed-cefuroxime
#17
Charles Mesnard, Laurence Beral, Rabih Hage, Harold Merle, Selim Farès, Thierry David
PURPOSE: To report a case series of post-phacoemulsification endophthalmitis despite antibiotic prophylaxis with an intracameral injection of a licensed cefuroxime formulation (Aprokam). SETTING: University Hospitals of Pointe-à-Pitre, Guadeloupe, and Fort-de-France, Martinique, French West Indies. DESIGN: Retrospective case series. METHODS: Patients who had cataract surgery with licensed cefuroxime prophylaxis between March 1, 2013, and July 31, 2015, and developed endophthalmitis were included...
September 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27586671/postoperative-endophthalmitis-incidence-after-intravitreal-therapy-a-comparison-of-two-different-preoperative-antibiotic-prophylaxis
#18
Sergio Piscitello, Maria Vadalà
Prevention of postoperative endophthalmitis (POE) is a goal of every ophthalmic procedure and also in intravitreal therapy (IVT). This comparative retrospective study targets whether systemic and topical preoperative antibiotic prophylaxis (PAP) regimen does prevent POE after IVT in a higher rate compared with topical PAP alone. Out of 6111 IVT performed over a period of 103.5 months, in the study group A patients were treated with systemic and topical PAP (2881 IVT), and in the study group B patients were treated only with topical PAP (3230 IVT)...
September 1, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27579452/post-cataract-surgery-endophthalmitis-brief-literature-review
#19
REVIEW
Hesam Hashemian, Reza Mirshahi, Mehdi Khodaparast, Mahmoud Jabbarvand
PURPOSE: To investigate recent evidence in prophylaxis and management of post-cataract surgery endophthalmitis. METHODS: We conducted a literature search using Pubmed database for post cataract surgery endophthalmitis, and relevant articles were selected from original English papers published since 2015. RESULTS: Forty-nine articles were published regarding post-cataract surgery endophthalmitis from January 2015 to February 2016. A low incidence of post-cataract surgery endophthalmitis has been reported...
September 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27448925/endophthalmitis-after-intravitreal-injections-in-patients-with-self-reported-iodine-allergy
#20
Bobeck S Modjtahedi, Tavé van Zyl, Hemang K Pandya, Robert E Leonard, Dean Eliott
PURPOSE: To present cases of endophthalmitis following intravitreal injections where povidone-iodine (PI) was not used as part of the surgical preparation. DESIGN: Retrospective case series. METHODS: All cases of presumed injection-related endophthalmitis presenting to the Massachusetts Eye and Ear Infirmary between June 2008 and November 2014 and Dean McGee Eye Institute between January 2010 and January 2015 were identified. Patients who did not receive PI preparation owing to documented self-reported allergy to iodine, iodine-containing contrast material, or shellfish were identified and their injection histories and clinical courses reviewed...
October 2016: American Journal of Ophthalmology
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