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Endophthalmitis prophylaxis

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https://www.readbyqxmd.com/read/28872724/successful-treatment-of-bilateral-endogenous-fusarium-solani-endophthalmitis-in-a-patient-with-acute-lymphocytic-leukemia
#1
Ilaria Rizzello, Fausto Castagnetti, Pier Giorgio Toschi, Patrizia Bertaccini, Laura Primavera, Michela Paolucci, Luca Faccioli, Luca Spinardi, Russell E Lewis, Michele Cavo, Marta Stanzani
Fusarium spp. are an uncommon cause of fungemia in immunocompromised and neutropenic patients that may hematogenously disseminate to the eyes. Herein, we describe a patient with acute lymphoblastic leukemia and a prior history of extensive corticosteroid exposure who developed disseminated Fusarium solani infection following chemotherapy despite posaconazole prophylaxis. She was successfully treated with combination liposomal amphotericin B and voriconazole, intraocular injections of voriconazole, topical amphotericin B and bilateral vitrectomy...
September 5, 2017: Mycoses
https://www.readbyqxmd.com/read/28832735/safety-and-efficacy-of-intracameral-moxifloxacin-injection-for-prophylaxis-of-endophthalmitis-after-phacoemulsification
#2
Ibraim Viana Vieira, Celso Boianovsky, Thais Jones Saraiva, Rodolfo Bregion de Godoy, Jonathan Lake
PURPOSE: To evaluate the safety and efficacy of 0.05 mL intracameral injection of moxifloxacin in patients who underwent phacoemulsification and intraocular lens (IOL) implant. METHODS: Retrospective study comprising patients who underwent phacoemulsification and IOL implant between January 2009 and December 2013. Patients were divided into two groups. Group A followed standard endophthalmitis prevention protocol and group B followed the same protocol plus intracameral injection of 0...
June 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28822873/surface-modification-of-an-intraocular-lens-material-by-plasma-assisted-grafting-with-2-hydroxyethyl-methacrylate-hema-for-controlled-release-of-moxifloxacin
#3
A Paula Vieira, Andreia F R Pimenta, Diana Silva, M Helena Gil, Patrícia Alves, Patrícia Coimbra, José L G C Mata, Dimitriya Bozukova, Tiago R Correia, Ilídio J Correia, A Paula Serro, A Jorge Guiomar
Endophthalmitis, an inflammation of the eye due to perioperative infection, may occur after cataract surgery. Intraocular lenses (IOLs) loaded with an antibiotic have been proposed as an alternative to the conventional postoperative endophthalmitis prophylaxis, since the antibiotic is delivered directly to the target site. In this work, an IOL-based antibiotic releasing system was prepared from a copolymer used in the production of IOLs and a fluoroquinolone used in endophthalmitis prophylaxis (moxifloxacin, MFX)...
August 16, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28780782/endophthalmitis-prophylaxis-for-cataract-surgery
#4
Aravind Haripriya, Zervin R Baam, David F Chang
Endophthalmitis after cataract surgery is a rare but potentially devastating complication. There is great variability in endophthalmitis prophylaxis practice patterns worldwide. Treatment varies globally and is based on the microbiological profile and availability of formulations. Periocular povidone-iodine antisepsis is universally adopted and considered the standard of care in most practices. Perioperative topical antibiotics are also very popular despite the lack of level 1 evidence confirming efficacy. Based on growing observational evidence, routine intracameral antibiotic prophylaxis is increasing, especially where approved commercial intraocular preparations are available...
July 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28732619/endophthalmitis-prophylaxis-by-intracameral-antibiotics-in%C3%A2-vitro-model%C3%A2-comparing-vancomycin-cefuroxime-%C3%A2-and%C3%A2-moxifloxacin
#5
Peter E Libre, Sean Mathews
PURPOSE: To compare the efficacy of intracameral vancomycin, cefuroxime, and moxifloxacin on postoperative bacterial endophthalmitis rates. SETTING: Norwalk Hospital, Norwalk, Connecticut, USA. DESIGN: Experimental study. METHODS: Bacteria and intraocular lenses (IOLs) were incubated with vancomycin, cefuroxime, moxifloxacin, or combinations. Antibiotic concentrations were high, corresponding to clinical maximum intracameral doses (1...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28546689/risks-of-cefuroxime-prophylaxis-for-postcataract-endophthalmitis
#6
REVIEW
Khaled A Al-Abduljabbar, Donald U Stone
BACKGROUND: Endophthalmitis after cataract surgery is a rare but vision-threatening complication. Intracameral cefuroxime (ICC) has been reported to be effective at reducing the risk, but concerns regarding the risks associated with this intervention remain. METHODS: Systematic review and synthesis of the literature on ICC, with a focus on the risks of therapy. RESULTS: Level 2a evidence was found to support the use of cefuroxime in penicillin-allergic patients...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28469481/simultaneous-bilateral-cataract-surgery-in-outreach-surgical-camps
#7
Kagmeni Giles, Ebana Steve Robert, Ebana Mvogo Come, Peter Wiedemann
OBJECTIVES: The aim of this study was to evaluate the safety and visual outcomes of simultaneous bilateral cataract surgery (SBCS) with intraocular lens implantation performed in outreach surgical eye camps. METHODS: The medical records of 47 consecutive patients who underwent simultaneous bilateral small-incision cataract surgery between January 2010 and December 2015 in outreach surgical camps in rural Cameroon were reviewed. The measures included postoperative visual outcomes and intraoperative and postoperative complications...
2017: Ophthalmology and Eye Diseases
https://www.readbyqxmd.com/read/28440583/topical-antibiotics-and-intravitreal-injections
#8
REVIEW
Alex P Hunyor, Rohan Merani, Archie Darbar, Jean-François Korobelnik, Paolo Lanzetta, Annabelle A Okada
There is increasing evidence that topical antibiotics, given before and/or after intravitreal injections, are ineffective in preventing endophthalmitis and are possibly harmful. In addition to the lack of efficacy and increased development of resistant organisms, the use of topical antibiotics adds significantly to the cost of delivering intravitreal therapy. Despite this, in many countries, it is still common practice to use pre- and/or postinjection topical antibiotics. This review outlines the general principles of effective antibiotic prophylaxis, and the evidence regarding topical antibiotic use as a prophylactic measure for endophthalmitis following intravitreal injections...
April 25, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28438590/antibiotic-prophylaxis-in-cataract-surgery-in-the-setting-of-penicillin-allergy-a-decision-making-algorithm
#9
REVIEW
Benjamin R LaHood, Nicholas H Andrew, Michael Goggin
Cataract surgery is the most commonly performed surgical procedure in many developed countries. Postoperative endophthalmitis is a rare complication with potentially devastating visual outcomes. Currently, there is no global consensus regarding antibiotic prophylaxis in cataract surgery despite growing evidence of the benefits of prophylactic intracameral cefuroxime at the conclusion of surgery. The decision about which antibiotic regimen to use is further complicated in patients reporting penicillin allergy...
April 22, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28328861/relationship-between-anesthesia-and-postoperative-endophthalmitis-a-retrospective-study
#10
Hou-Chuan Lai, Wei-Cheng Tseng, Shu-I Pao, Chih-Shung Wong, Ren-Chih Huang, Wei-Hung Chan, Zhi-Fu Wu
Previous study showed that patients under general anesthesia (GA) had nasopharyngeal secretions on the face at the end of ocular surgery, especially in propofol-based total intravenous anesthesia (TIVA), it might induce postoperative endophthalmitis. Therefore, we conducted a retrospective study to compare the incidence of endophthalmitis after ocular surgery under topical, inhalation anesthesia, and propofol-based TIVA in our medical center from 2011 to 2015.A total of 21,032 patients were included, and we evaluated epidemiologic factors, systemic diseases, other ocular pathologic characteristics, complications during the surgery, technique of ocular surgery, method of antibiotic prophylaxis, vitreous culture, and vision outcome in these patients...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28267115/pooled-estimates-of-incidence-of-endophthalmitis-after-intravitreal-injection-of-anti-vascular-endothelial-growth-factor-agents-with-and-without-topical-antibiotic-prophylaxis
#11
Michele Reibaldi, Alfredo Pulvirenti, Teresio Avitabile, Vincenza Bonfiglio, Andrea Russo, Cesare Mariotti, Claudio Bucolo, Rodolfo Mastropasqua, Guglielmo Parisi, Antonio Longo
PURPOSE: To assess the effect of topical antibiotic prophylaxis on postoperative endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents. METHODS: A systematic literature search was performed from inception to March 2016 using PubMed, Medline, Web of Science, Embase, and the Cochrane Library, to identify articles that reported cases of endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents...
March 6, 2017: Retina
https://www.readbyqxmd.com/read/28214101/endophthalmitis-reduction-with-intracameral-moxifloxacin-prophylaxis-analysis-of-600%C3%A2-000-surgeries
#12
COMPARATIVE STUDY
Aravind Haripriya, David F Chang, Ravilla D Ravindran
PURPOSE: To compare the postoperative endophthalmitis rate before and after initiation of intracameral (IC) moxifloxacin prophylaxis for both phacoemulsification and sutureless, manual small-incision cataract surgery (M-SICS), as well as in patients with posterior capsular rupture (PCR). DESIGN: Retrospective, clinical registry. PARTICIPANTS: All cataract surgeries (617 453) performed during the 29-month period from January 2014 to May 2016 at the 10 regional Aravind eye hospitals were included...
June 2017: Ophthalmology
https://www.readbyqxmd.com/read/28192644/perioperative-antibiotics-for-prevention-of-acute-endophthalmitis-after-cataract-surgery
#13
REVIEW
Emily W Gower, Kristina Lindsley, Samantha E Tulenko, Afshan A Nanji, Ilya Leyngold, Peter J McDonnell
BACKGROUND: Endophthalmitis is a severe inflammation of the anterior or posterior (or both) chambers of the eye that may be sterile or associated with infection. It is a potentially vision-threatening complication of cataract surgery. Prophylactic measures for endophthalmitis are targeted against various sources of infection. OBJECTIVES: To evaluate the effects of perioperative antibiotic prophylaxis for endophthalmitis following cataract surgery compared with no prophylaxis or other form of prophylaxis...
February 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28013528/pathogens-and-antibiotic-sensitivities-in-endophthalmitis
#14
Geraldine R Slean, Neal H Shorstein, Liyan Liu, John F Paschal, Kevin L Winthrop, Lisa J Herrinton
BACKGROUND: Antibiotic prophylaxis in cataract surgery is intended to minimize endophthalmitis. We describe pathogenic organisms, antibiotic sensitivities and antibiotic prophylaxis in culture-proven endophthalmitis cases. DESIGN: Retrospective consecutive case series and community-based setting were used. PARTICIPANTS: Two hundred fifteen cases of endophthalmitis after cataract surgery performed during 2007-2012 in Kaiser Permanente, California...
July 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28007117/anaphylactic-reaction-secondary-to-topical-preoperative-moxifloxacin
#15
Michael A Ullman, Kirsten J Midgley, Jocelyn Kim, Saul Ullman
We report a case of anaphylactic shock following topical administration of moxifloxacin for endophthalmitis prophylaxis prior to cataract surgery. Immunoglobulin E (IgE) serology and IgE skin testing confirmed the anaphylactic etiology. Phacoemulsification with posterior chamber intraocular lens implantation was later performed with identical preoperative preparation except for the exclusion of moxifloxacin; no anaphylactic response occurred. To our knowledge, this is the first report of an anaphylactic response to topical moxifloxacin...
December 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28007104/dose-and-administration-of-intracameral-moxifloxacin-for-prophylaxis-of-postoperative-endophthalmitis
#16
Steve A Arshinoff, Milad Modabber
PURPOSE: To review current and past practices of intracameral antibiotic administration for infection prophylaxis in cataract surgery; to review the benefits and liabilities of available prophylactic drugs, dosage determination, and administration protocols; and to devise an optimum dose and administration protocol for intracameral moxifloxacin. SETTING: Humber River Hospital and the University of Toronto, Toronto, Ontario, Canada. DESIGN: Retrospective evaluation of treatment modality...
December 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27981903/endophthalmitis-prophylaxis-in-cataract-surgery-overview-of-current-practice-patterns-around-the-world
#17
Andrzej Grzybowski, Stephen G Schwartz, Kazuki Matsuura, Stephan O Tone, Steve Arshinoff, Jonathon Q Ng, Jay J Meyer, Wu Liu, Soosan Jacob, Mark Packer, Rifna Lutfiamida, Sjakon Tahija, Paul Roux, Boris Malyugin, Julio A Urrets-Zavalia, Nicolas Crim, Evangelina Esposito, Pablo Daponte, Fernando Pellegrino, Enrique O Graue-Hernandez, Aida Jimenez-Corona, Jorge E Valdez-Garcia, Julio C Hernandez-Camarena, Nidhi Relhan, Harry W Flynn, Ravilla D Ravindran, Anders Behnding
BACKGROUND: Acute-onset postoperative endophthalmitis after cataract surgery remains a rare but important cause of visual loss. There is no global consensus regarding the optimal strategies for prophylaxis of endophthalmitis and practices vary substantially around the world, especially with respect to the use of intracameral antibiotics. The European Society of Cataract & Refractive Surgeons in a randomized clinical trial (2007) reported an approximately 5-fold reduction in endophthalmitis rates associated with the use of intracameral cefuroxime...
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27956296/postoperative-hemorrhagic-occlusive-retinal-vasculitis-associated-with-intracameral-vancomycin-prophylaxis-during%C3%A2-cataract-surgery
#18
Matthew A Miller, Lucas T Lenci, Chittaranjan V Reddy, Stephen R Russell
We present the case of a 75-year-old man who had uneventful cataract surgery and administration of intracameral vancomycin for endophthalmitis prophylaxis, followed by the same procedure in the fellow eye 1 week later. The patient subsequently developed bilateral hemorrhagic occlusive retinal vasculitis, resulting in profound vision loss in both eyes. A second case of hemorrhagic occlusive retinal vasculitis previously reported from our institution is summarized. That case was characterized by a far milder course, with rapid resolution of vision loss...
November 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27933222/endophthalmitis-prophylaxis-using-a-single-drop-of-thermoresponsive-controlled-release-microspheres-loaded-with-moxifloxacin-in-a-rabbit-model
#19
Alex Mammen, Eric G Romanowski, Morgan V Fedorchak, Deepinder K Dhaliwal, R M Shanks, Regis P Kowalski
PURPOSE: Postsurgical endophthalmitis is a sight-threatening problem. We introduce a simple approach by using a single application of thermoresponsive controlled-release microspheres, loaded with moxifloxacin, to prevent bacterial endophthalmitis in a rabbit endophthalmitis prevention model. METHODS: We separated 24 rabbits into 3 treatment groups in which topical drop treatment was placed onto the conjunctival cul-de-sac: (1) a single drop of controlled-release microspheres containing moxifloxacin, (2) a single drop of controlled-release microspheres without moxifloxacin, and (3) multiple topical treatment with moxifloxacin alone every 15 minutes for 1 hour...
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27822008/an-updated-estimate-of-costs-of-endophthalmitis-following-cataract-surgery-among-medicare-patients-2010-2014
#20
Jordana K Schmier, Carolyn K Hulme-Lowe, David W Covert, Edmund C Lau
BACKGROUND: Endophthalmitis, which can occur after ophthalmic surgery, is an inflammation of the intraocular cavity and causes temporary or permanent vision impairment. However, little is known about the cost of treatment. The objective of this analysis was to update and expand upon the results of a previously published report that estimated the direct medical cost of treatment for endophthalmitis. METHODS: Retrospective data analysis using 2010 through 2014 United States Medicare Limited Data Sets...
2016: Clinical Ophthalmology
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