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Endophthalmitis prophylaxis

Mustafa Erdoğan Cicik, Cezmi Doğan, Osman Şevki Arslan
BACKGROUND: Development of endophthalmitis during cataract surgery is one of the most severe complications and it may also result in blindness and globe loss. AIMS: To evaluate the effect of an ophthalmic cefuroxime solution (Aprokam® ) that is prophylactically used in phacoemulsification surgery performed due to cataract that eventually occurs in patients with or without penetrating keratoplasty. STUDY DESIGN: Case-control study. METHODS: In this retrospective study, patients who had undergone penetrating keratoplasty and for whom phacoemulsification surgery was performed due to cataract and an intracameral ophthalmic cefuroxime solution (Aprokam® ) was administered for prophylaxis were evaluated in comparison with patients with cataract without keratoplasty...
March 15, 2018: Balkan Medical Journal
L Simon, L Gastaud, D Martiano, C Bailleux, L Hasseine, M Gari-Toussaint
Endophthalmitis is a rare infection of the vitreous and/or aqueous. It can be bacterial or fungal. Exogenous endophthalmitis is the most common form and results from direct inoculation of a pathogen after eye surgery or penetrating trauma. Endophthalmitis can also be endogenous, secondary to disseminated infection. Fungal endophthalmitis is associated with poor prognosis and treatment is difficult given the low penetration of most of the antifungal agents available and the emergence of resistant filamentous fungi like Fusarium...
February 21, 2018: Journal de Mycologie Médicale
E Friling, P Montan
BACKGROUND: Intracameral cefuroxime as prophylaxis against postoperative endophthalmitis (POE) following cataract surgery was introduced in 1996 at St Erik Eye Hospital. Soon after the introduction of intracameral cefuroxime the rate of POE fell dramatically and a shift in the aetiology was noticed. AIM: To analyse bacteriology and susceptibility to cefuroxime before and after the introduction. METHODS: All culture-proven endophthalmitis cases at St Erik Eye Hospital after cataract surgery performed over a 20-year period were included in a retrospective observational study...
February 9, 2018: Journal of Hospital Infection
Cesar Ramon G Espiritu, Joanne G Bolinao
Purpose: To evaluate posterior and anterior segment safety of an intracameral injection of levofloxacin 0.5% ophthalmic solution as prophylaxis for patients undergoing cataract extraction and intraocular lens implantation. Setting: This study was conducted at Manila Doctors Hospital, Ermita, Manila, Philippines. Design: This was a prospective interventional study. Methods: Eyes undergoing standard phacoemulsification cataract surgery with intraocular lens implantation were treated with intracameral levofloxacin 0...
2017: Clinical Ophthalmology
Manuel F Bande, Raquel Mansilla, María P Pata, Maribel Fernández, María José Blanco-Teijeiro, Antonio Piñeiro, Francisco Gómez-Ulla
We performed a systematic review and meta-analysis to determine whether the use of local antibiotics is a beneficial prophylactic treatment for endophthalmitis in patients treated with anti-VEGF agents. We searched the MEDLINE and EMBASE databases, and the Cochrane Library over the period January 2007 to December 2016. The search terms used included "Endophthalmitis", "Antibiotic" and "Intravitreal injection". Studies in which the patients were treated exclusively with intravitreal injections of anti-VEGF were selected...
December 22, 2017: Scientific Reports
Nidhi Relhan, Richard K Forster, Harry W Flynn
PURPOSE: To report historically evolving strategies (then and now) in prevention and management of endophthalmitis. DESIGN: A perspective on relevant topics in the prophylaxis and management of endophthalmitis. METHODS: This is an author-selected review of studies leading to changes in strategies for endophthalmitis management over the last 100 years. RESULTS: The current perspective discusses the trends and strategies over the past century...
March 2018: American Journal of Ophthalmology
Suven Bhattacharjee
No abstract text is available yet for this article.
December 2017: Indian Journal of Ophthalmology
Aditya S Kelkar, David F Chang, Jai A Kelkar, Hetal M Mehta, Tatyarao Lahane, Ragini Parekh
PURPOSE: The aim of this study is to assess the current antibiotic prophylaxis practice patterns for cataract surgery in India. METHODS: This was a questionnaire-based E-survey carried out at a tertiary eye care center in India. An E-mail invitation to complete an online 20 point questionnaire survey was sent to all members of the All India Ophthalmological Society with valid E-mail addresses using a digital E-mail service. Duplicate entries were prevented. RESULTS: Out of 1228 total respondents (8...
December 2017: Indian Journal of Ophthalmology
Aravind Haripriya
Various protocols are being followed for endophthalmitis prophylaxis in cataract surgery, and this subject continues to be a matter of debate. We summarize the most recent evidence-based studies on this topic with additional stress on intracameral (IC) antibiotic prophylaxis. Here, we discuss several large, international clinical studies which discuss the efficacy, adoption, safety, cost, and newer trends in antibiotic prophylaxis. Majority of these studies report a significant reduction in endophthalmitis rates with IC antibiotic prophylaxis...
December 2017: Indian Journal of Ophthalmology
Taraprasad Das
No abstract text is available yet for this article.
December 2017: Indian Journal of Ophthalmology
Safa Rahmani, Dean Eliott
Postoperative endophthalmitis is one of the most feared complications of intraocular surgery. The most common types of intraocular surgeries performed worldwide are cataract extraction, glaucoma drainage implants/trabeculectomy, and pars plana vitrectomy. This review will focus on the clinical features, risk factors, prophylaxis, and treatment of endophthalmitis in these three main intraocular surgeries.
2018: Seminars in Ophthalmology
Aravind Haripriya, David F Chang
PURPOSE OF REVIEW: There is continuing debate regarding the safety, efficacy, and necessity of intracameral antibiotics to prevent postoperative endophthalmitis. We summarize the most recent evidence-based publications that either support or caution against this practice. RECENT FINDINGS: Several additional large, international retrospective clinical studies found a significant reduction in endophthalmitis rates with intracameral antibiotic prophylaxis. Many surgeons are looking for alternatives to vancomycin for intracameral prophylaxis because of its association with the rare but sight-threatening complication of hemorrhagic occlusive retinal vasculitis...
January 2018: Current Opinion in Ophthalmology
Almutez M Gharaibeh, Eedy Mezer, Luis H Ospina, Tamara Wygnanski-Jaffe
PURPOSE: To compile international data on the risk factors, diagnosis, and treatment of endophthalmitis following pediatric cataract surgery. METHODS: An e-mail containing a link to an online survey was sent to all members of the American Association for Pediatric Ophthalmology and Strabismus. The questionnaire examined the incidence, risk factors, treatment, outcomes, and prophylaxis of endophthalmitis following pediatric cataract surgery around the world. RESULTS: Two hundred thirty-seven ophthalmologists answered the questionnaire...
October 9, 2017: Journal of Pediatric Ophthalmology and Strabismus
Andrzej Grzybowski, Piotr Kanclerz, William G Myers
PURPOSE OF REVIEW: Povidone-iodine (PVI) is a disinfectant and antiseptic agent used for preoperative preparation of the skin and mucous membranes, as well as for the treatment of contaminated wounds. Currently regimens for prophylaxis against postsurgical endophthalmitis are being modified, including a total withdrawal of antibiotics in intravitreal injections. The aim of this study was to evaluate the use of PVI in ophthalmology. RECENT FINDINGS: As a result of its broad spectrum of microbicidal activity, PVI is routinely used in ophthalmic surgery...
January 2018: Current Opinion in Ophthalmology
Kourosh Shahraki, Mohammad Naeim Amini Fard, Farkhondeh Shahri, Rama Pourmatin, Tafgeh Mohammadi, Paria Ghasemi Boroumand, Kianoush Shahraki
BACKGROUND: Endophthalmitis is one of the most important complications after cataract surgery and in case event can cause many symptoms, such as severe decrease in eyesight and/or even the loss of vision. Employing methods to reduce this problem is very important. The aim of this study was to evaluate the effect of intracameral cefuroxime after cataract surgery on corneal endothelial cell counts and its morphology. METHODS: In this study, 32 eyes of 30 patients underwent endothelial cell count and morphology assessment by ConfoScan III device before and 1 month after cataract surgery...
June 2017: Interventional Medicine & Applied Science
Ilaria Rizzello, Fausto Castagnetti, Pier Giorgio Toschi, Patrizia Bertaccini, Laura Primavera, Michela Paolucci, Luca Faccioli, Luca Spinardi, Russell E Lewis, Michele Cavo, Marta Stanzani
Fusarium spp. are an uncommon cause of fungaemia in immunocompromised and neutropenic patients that may hematogenously disseminate to the eyes. Herein, we describe a patient with acute lymphoblastic leukaemia and a prior history of extensive corticosteroid exposure who developed disseminated Fusarium solani infection following chemotherapy despite posaconazole prophylaxis. She was successfully treated with combination liposomal amphotericin B and voriconazole, intraocular injections of voriconazole, topical amphotericin B and bilateral vitrectomy...
September 5, 2017: Mycoses
Ibraim Viana Vieira, Celso Boianovsky, Thais Jones Saraiva, Rodolfo Bregion de Godoy, Jonathan Lake
PURPOSE: To evaluate the safety and efficacy of 0.05 mL intracameral injection of moxifloxacin in patients who underwent phacoemulsification and intraocular lens (IOL) implant. METHODS: Retrospective study comprising patients who underwent phacoemulsification and IOL implant between January 2009 and December 2013. Patients were divided into two groups. Group A followed standard endophthalmitis prevention protocol and group B followed the same protocol plus intracameral injection of 0...
June 2017: Arquivos Brasileiros de Oftalmologia
A Paula Vieira, Andreia F R Pimenta, Diana Silva, M Helena Gil, Patrícia Alves, Patrícia Coimbra, José L G C Mata, Dimitriya Bozukova, Tiago R Correia, Ilídio J Correia, A Paula Serro, A Jorge Guiomar
Endophthalmitis, an inflammation of the eye due to perioperative infection, may occur after cataract surgery. Intraocular lenses (IOLs) loaded with an antibiotic have been proposed asan alternative to the conventional postoperative endophthalmitis prophylaxis, since the antibiotic is delivered directly to the target site. In this work, an IOL-based antibiotic releasing system was prepared from a copolymer used in the production of IOLs and a fluoroquinolone used in endophthalmitis prophylaxis (moxifloxacin, MFX)...
November 2017: European Journal of Pharmaceutics and Biopharmaceutics
Aravind Haripriya, Zervin R Baam, David F Chang
Endophthalmitis after cataract surgery is a rare but potentially devastating complication. There is great variability in endophthalmitis prophylaxis practice patterns worldwide. Treatment varies globally and is based on the microbiological profile and availability of formulations. Periocular povidone-iodine antisepsis is universally adopted and considered the standard of care in most practices. Perioperative topical antibiotics are also very popular despite the lack of level 1 evidence confirming efficacy. Based on growing observational evidence, routine intracameral antibiotic prophylaxis is increasing, especially where approved commercial intraocular preparations are available...
July 2017: Asia-Pacific Journal of Ophthalmology
Peter E Libre, Sean Mathews
PURPOSE: To compare the efficacy of intracameral vancomycin, cefuroxime, and moxifloxacin on postoperative bacterial endophthalmitis rates. SETTING: Norwalk Hospital, Norwalk, Connecticut, USA. DESIGN: Experimental study. METHODS: Bacteria and intraocular lenses (IOLs) were incubated with vancomycin, cefuroxime, moxifloxacin, or combinations. Antibiotic concentrations were high, corresponding to clinical maximum intracameral doses (1...
June 2017: Journal of Cataract and Refractive Surgery
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