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Endophthalmitis prophylaxis

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https://www.readbyqxmd.com/read/28013528/pathogens-and-antibiotic-sensitivities-in-endophthalmitis
#1
Geraldine R Slean, Neal H Shorstein, Liyan Liu, John F Paschal, Kevin L Winthrop, Lisa J Herrinton
BACKGROUND: Antibiotic prophylaxis in cataract surgery is intended to minimize endophthalmitis. We describe pathogenic organisms, antibiotic sensitivities, and antibiotic prophylaxis in culture-proven endophthalmitis cases. DESIGN: Retrospective consecutive case series, community-based setting. SAMPLES: 215 cases of endophthalmitis after cataract surgery performed during 2007-2012 in Kaiser Permanente, California. METHODS AND MAIN OUTCOME MEASURES: Descriptive analysis of isolated organisms and antibiotic sensitivities in relation to antibiotic prophylaxis in culture-proven endophthalmitis cases...
December 25, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28007117/anaphylactic-reaction-secondary-to-topical-preoperative-moxifloxacin
#2
Michael A Ullman, Kirsten J Midgley, Jocelyn Kim, Saul Ullman
: We report a case of anaphylactic shock following topical administration of moxifloxacin for endophthalmitis prophylaxis prior to cataract surgery. Immunoglobulin E (IgE) serology and IgE skin testing confirmed the anaphylactic etiology. Phacoemulsification with posterior chamber intraocular lens implantation was later performed with identical preoperative preparation except for the exclusion of moxifloxacin; no anaphylactic response occurred. To our knowledge, this is the first report of an anaphylactic response to topical moxifloxacin...
December 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28007104/dose-and-administration-of-intracameral-moxifloxacin-for-prophylaxis-of-postoperative-endophthalmitis
#3
Steve A Arshinoff, Milad Modabber
PURPOSE: To review current and past practices of intracameral antibiotic administration for infection prophylaxis in cataract surgery; to review the benefits and liabilities of available prophylactic drugs, dosage determination, and administration protocols; and to devise an optimum dose and administration protocol for intracameral moxifloxacin. SETTING: Humber River Hospital and the University of Toronto, Toronto, Ontario, Canada. DESIGN: Retrospective evaluation of treatment modality...
December 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27981903/endophthalmitis-prophylaxis-in-cataract-surgery-overview-of-current-practice-patterns-around-the-world
#4
Andrzej Grzybowski, Stephen G Schwartz, Kazuki Matsuura, Stephan Ong Tone, Steve Arshinoff, Ng Q Jonathon, Jay J Meyer, Wu Liu, Soosan Jacob, Mark Packer, Rifna Lutfiamida, Sjakon Tahija, Paul Roux, Boris Malyugin, Julio A Urrets-Zavalia, Nicolas Crim, Evangelina Esposito, Pablo Daponte, Fernando Pellegrino, Enrique O Graue-Hernandez, Aida Jimenez-Corona, Jorge Valdez Garcia, Julio C Hernandez-Camarena, Nidhi Relhan, Harry W Flynn, Ravilla D Ravindran
BACKGROUND: Acute-onset postoperative endophthalmitis after cataract surgery remains a rare but important cause of visual loss. There is no global consensus regarding the optimal strategies for prophylaxis of endophthalmitis and practices vary substantially around the world, especially with respect to the use of intracameral antibiotics. The European Society of Cataract & Refractive Surgeons in a randomized clinical trial (2007) reported an approximately 5-fold reduction in endophthalmitis rates associated with the use of intracameral cefuroxime...
16, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27956296/postoperative-hemorrhagic-occlusive-retinal-vasculitis-associated-with-intracameral-vancomycin-prophylaxis-during%C3%A2-cataract-surgery
#5
Matthew A Miller, Lucas T Lenci, Chittaranjan V Reddy, Stephen R Russell
: We present the case of a 75-year-old man who had uneventful cataract surgery and administration of intracameral vancomycin for endophthalmitis prophylaxis, followed by the same procedure in the fellow eye 1 week later. The patient subsequently developed bilateral hemorrhagic occlusive retinal vasculitis, resulting in profound vision loss in both eyes. A second case of hemorrhagic occlusive retinal vasculitis previously reported from our institution is summarized. That case was characterized by a far milder course, with rapid resolution of vision loss...
November 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27933222/endophthalmitis-prophylaxis-using-a-single-drop-of-thermoresponsive-controlled-release-microspheres-loaded-with-moxifloxacin-in-a-rabbit-model
#6
Alex Mammen, Eric G Romanowski, Morgan V Fedorchak, Deepinder K Dhaliwal, R M Shanks, Regis P Kowalski
PURPOSE: Postsurgical endophthalmitis is a sight-threatening problem. We introduce a simple approach by using a single application of thermoresponsive controlled-release microspheres, loaded with moxifloxacin, to prevent bacterial endophthalmitis in a rabbit endophthalmitis prevention model. METHODS: We separated 24 rabbits into 3 treatment groups in which topical drop treatment was placed onto the conjunctival cul-de-sac: (1) a single drop of controlled-release microspheres containing moxifloxacin, (2) a single drop of controlled-release microspheres without moxifloxacin, and (3) multiple topical treatment with moxifloxacin alone every 15 minutes for 1 hour...
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27822008/an-updated-estimate-of-costs-of-endophthalmitis-following-cataract-surgery-among-medicare-patients-2010-2014
#7
Jordana K Schmier, Carolyn K Hulme-Lowe, David W Covert, Edmund C Lau
BACKGROUND: Endophthalmitis, which can occur after ophthalmic surgery, is an inflammation of the intraocular cavity and causes temporary or permanent vision impairment. However, little is known about the cost of treatment. The objective of this analysis was to update and expand upon the results of a previously published report that estimated the direct medical cost of treatment for endophthalmitis. METHODS: Retrospective data analysis using 2010 through 2014 United States Medicare Limited Data Sets...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27817919/incidence-and-outcomes-of-positive-donor-corneoscleral-rim-fungal-cultures-after-keratoplasty
#8
Jesse M Vislisel, Kenneth M Goins, Michael D Wagoner, Gregory A Schmidt, Benjamin T Aldrich, Jessica M Skeie, Cynthia R Reed, M Bridget Zimmerman, Mark A Greiner
PURPOSE: To determine the incidence of positive corneoscleral donor rim fungal cultures after keratoplasty and to report clinical outcomes of grafts with culture-positive donor rims. DESIGN: Retrospective cohort study. PARTICIPANTS: Consecutive donor corneas and keratoplasty recipients at a single tertiary referral center over 20 years. METHODS: Patient charts were reviewed to determine the incidence of positive donor rim fungal cultures and clinical outcomes of all grafts using contaminated tissue...
January 2017: Ophthalmology
https://www.readbyqxmd.com/read/27793818/randomised-controlled-trial-of-prophylactic-antibiotic-treatment-for-the-prevention-of-endophthalmitis-after-open-globe-injury-at-groote-schuur-hospital
#9
N Du Toit, S Mustak, C Cook
BACKGROUND/AIMS: Most post-traumatic acute infectious endophthalmitis occur within a week of open globe trauma, necessitating early antibiotic prophylaxis. There are few randomised studies that demonstrate the benefits of prophylactic antibiotics. This randomised controlled non-inferiority trial was aimed at determining the incidence of post-traumatic endophthalmitis using established intravenous/oral prophylaxis and comparing this to the incidence using oral antibiotics only. METHODS: All adult patients admitted with open globe injury were included...
October 28, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27720552/aqueous-chlorhexidine-for-intravitreal-injection-antisepsis-a-case-series-and-review-of-the-literature
#10
Rohan Merani, Zachary E McPherson, Alan P Luckie, Jagjit S Gilhotra, Jim Runciman, Shane Durkin, James Muecke, Mark Donaldson, Albert Aralar, Anupam Rao, Peter E Davies
PURPOSE: To determine the incidence of endophthalmitis in a large clinical series using aqueous chlorhexidine for antisepsis before intravitreal injection and to review the ophthalmic literature regarding chlorhexidine efficacy and safety. DESIGN: Multicenter retrospective case series. PARTICIPANTS: All patients receiving intravitreal injections from 7 retinal specialists. METHODS: An audit of intravitreal injections performed by retinal specialists who exclusively used aqueous chlorhexidine 0...
October 6, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27697250/endophthalmitis-after-cataract-surgery-despite-intracameral-antibiotic-prophylaxis-with-licensed-cefuroxime
#11
Charles Mesnard, Laurence Beral, Rabih Hage, Harold Merle, Selim Farès, Thierry David
PURPOSE: To report a case series of post-phacoemulsification endophthalmitis despite antibiotic prophylaxis with an intracameral injection of a licensed cefuroxime formulation (Aprokam). SETTING: University Hospitals of Pointe-à-Pitre, Guadeloupe, and Fort-de-France, Martinique, French West Indies. DESIGN: Retrospective case series. METHODS: Patients who had cataract surgery with licensed cefuroxime prophylaxis between March 1, 2013, and July 31, 2015, and developed endophthalmitis were included...
September 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27586671/postoperative-endophthalmitis-incidence-after-intravitreal-therapy-a-comparison-of-two-different-preoperative-antibiotic-prophylaxis
#12
Sergio Piscitello, Maria Vadalà
Prevention of postoperative endophthalmitis (POE) is a goal of every ophthalmic procedure and also in intravitreal therapy (IVT). This comparative retrospective study targets whether systemic and topical preoperative antibiotic prophylaxis (PAP) regimen does prevent POE after IVT in a higher rate compared with topical PAP alone. Out of 6111 IVT performed over a period of 103.5 months, in the study group A patients were treated with systemic and topical PAP (2881 IVT), and in the study group B patients were treated only with topical PAP (3230 IVT)...
September 1, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27579452/post-cataract-surgery-endophthalmitis-brief-literature-review
#13
REVIEW
Hesam Hashemian, Reza Mirshahi, Mehdi Khodaparast, Mahmoud Jabbarvand
PURPOSE: To investigate recent evidence in prophylaxis and management of post-cataract surgery endophthalmitis. METHODS: We conducted a literature search using Pubmed database for post cataract surgery endophthalmitis, and relevant articles were selected from original English papers published since 2015. RESULTS: Forty-nine articles were published regarding post-cataract surgery endophthalmitis from January 2015 to February 2016. A low incidence of post-cataract surgery endophthalmitis has been reported...
September 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27448925/endophthalmitis-after-intravitreal-injections-in-patients-with-self-reported-iodine-allergy
#14
Bobeck S Modjtahedi, Tavé van Zyl, Hemang K Pandya, Robert E Leonard, Dean Eliott
PURPOSE: To present cases of endophthalmitis following intravitreal injections where povidone-iodine (PI) was not used as part of the surgical preparation. DESIGN: Retrospective case series. METHODS: All cases of presumed injection-related endophthalmitis presenting to the Massachusetts Eye and Ear Infirmary between June 2008 and November 2014 and Dean McGee Eye Institute between January 2010 and January 2015 were identified. Patients who did not receive PI preparation owing to documented self-reported allergy to iodine, iodine-containing contrast material, or shellfish were identified and their injection histories and clinical courses reviewed...
October 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27414817/use-of-intravenous-vancomycin-and-cefepime-in-preventing-endophthalmitis-after-open-globe-injury
#15
Jason M Huang, Andrew D Pansick, Preston H Blomquist
PURPOSE: The choice and route of antibiotic prophylaxis in the setting of open globe injury remains controversial. We investigated the utility of intravenous vancomycin and cefepime prophylaxis in preventing endopthalmitis after open globe injury. METHODS: The charts of 224 patients who presented to Parkland Memorial Hospital and Children's Medical Center in Dallas, Texas, between June 1, 2009 and June 30, 2013, with open globe injury and who were treated with prophylactic intravenous vancomycin and cefepime were retrospectively reviewed...
September 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27311743/efficacy-and-cost-effectiveness-of-intracameral-vancomycin-in-reducing-postoperative-endophthalmitis-incidence-in-australia
#16
Cheryl Py Au, Andrew Jr White, Paul R Healey
BACKGROUND: Endophthalmitis is a rare but devastating postoperative complication of cataract surgery. We aimed to describe the incidence of acute postoperative endophthalmitis in an Australian population over a 14-year period. DESIGN: This was a retrospective longitudinal cohort study performed at Westmead Hospital, a major tertiary hospital in Sydney, Australia. PARTICIPANTS: Patients who had acute postoperative endophthalmitis within 6 weeks of their cataract surgery at Westmead Hospital were included...
December 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27275777/survey-of-intraocular-antibiotics-prophylaxis-practice-after-open-globe-injury-in-china
#17
Bingsheng Lou, Lixia Lin, Junlian Tan, Yao Yang, Zhaohui Yuan, Xiaofeng Lin
PURPOSE: To elucidate the Chinese practice of intraocular antibiotics administration for prophylaxis after open globe injury. METHODS: A cross-sectional questionnaire survey was performed online by scanning a Quickmark (QR) code with smartphones at the 20th Chinese National Conference of Ocular Trauma in November 2014. RESULTS: A total of 153 (30.6%) of all participators at the conference responded. Of the respondents, 20.9% were routinely administered with prophylactic intraocular injection of antibiotics at the conclusion of the primary eye repair, and 56...
2016: PloS One
https://www.readbyqxmd.com/read/27257676/antibioprophylaxis-in-prevention-of-endophthalmitis-in-intravitreal-injection-a-systematic-review-and-meta-analysis
#18
Cédric Benoist d'Azy, Bruno Pereira, Geraldine Naughton, Frédéric Chiambaretta, Frédéric Dutheil
Despite endophthalmitis being the most feared complication, antibioprophylaxis remains controversial in intravitreal injections. Therefore, we conducted a systematic review and meta-analysis on the effects of antibioprophylaxis in intravitreal injections in the prevention of endophthalmitis. The PubMed, Cochrane Library, Embase and Science Direct databases were searched for studies comparing groups with and without antibiotics in intravitreal injection, with the use of the following keywords: "antibiotic*", "endophthalmitis" and "intravitreal injection*"...
2016: PloS One
https://www.readbyqxmd.com/read/26959132/fungal-infections-in-boston-keratoprosthesis-patients-lessons-learned-and-novel-developments-on-the-horizon
#19
REVIEW
Silvia Odorcic, Saama Sabeti, Wolfgang Haas, Marlene L Durand, Claes H Dohlman
The Boston Keratoprosthesis (B-KPro) is a widely accepted modality of corneal restoration in eyes where traditional penetrating keratoplasty has little chance of success. It is the most commonly used keratoprosthesis worldwide. While the introduction of broad-spectrum antibiotic prophylaxis has virtually eliminated cases of bacterial endophthalmitis, fungal colonization and infections are a growing concern. This review of the literature summarizes risk factors for fungal infections in KPro eyes, rates of fungal infection and colonization, clinical presentation, causative organisms, management, and outcomes...
2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/26941346/endogenous-candida-endophthalmitis-and-osteomyelitis-associated-with-card9-deficiency
#20
Nicholas Jones, Tomaz Garcez, William Newman, David Denning
A 25-year-old woman presented with unilateral red eye and visual blur, and was found to have panuveitis with an inflammatory white mass at the macula, initially presumed to be Toxoplasma retinitis. After failure to respond, she underwent vitrectomy, which produced Candida albicans. Despite intraocular and systemic antifungal treatment, she lost all vision in that eye. Two years later, she developed unilateral hip osteomyelitis leading to total hip replacement and also revealing Candida infection. By clinical exome sequencing, she was then found to have caspase recruitment domain 9 (CARD9) deficiency, an autosomal recessive disorder that causes a specific susceptibility to candidal infections...
March 3, 2016: BMJ Case Reports
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