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https://www.readbyqxmd.com/read/28094575/treatment-approaches-of-hard-to-treat-non-hodgkin-lymphomas
#1
Lakshminarayanan Nandagopal, Amitkumar Mehta
Even after recent advancements with monoclonal antibodies, antibody drug conjugates and immune therapies, relapsed and refractory lymphomas remain challenging to treat; and the definition and treatment approaches of hard-to-treat lymphomas (HTL) continue to evolve. Areas covered: In this review, we will address HTL encompassing diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL) and peripheral T cell lymphomas (PTCL). DLBCL, which comprises 30-40% of non-Hodgkin lymphomas is a highly aggressive and heterogeneous malignancy, with primary refractory or relapsed disease remaining a therapeutic challenge...
January 17, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28091990/revaluation-of-stockpile-amount-of-pfos-containing-aqueous-film-forming-foam-in-japan-gaps-and-pitfalls-in-the-stockpile-survey
#2
Yasuyuki Zushi, Atsushi Yamamoto, Kiyotaka Tsunemi, Shigeki Masunaga
Stockpiles of perfluoro-octane sulfonic acid (PFOS) containing aqueous film-forming foam (AFFF) have the potential to be emitted by leaching, spills, and during use in fire response and other processes. Several studies have discussed the high levels of stockpiled PFOS-containing AFFF and the risk they pose to the environment; however, there are large gaps in the amounts in Japan compared with other countries. For example, 300 tons are stockpiled in Canada, 2200-2600 tons in Switzerland, 1400 tons in Norway, and 19,000 tons in Japan from their reports for publication...
January 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28050972/registration-of-mri-to-intraoperative-radiographs-for-target-localization-in-spinal-interventions
#3
T De Silva, A Uneri, M D Ketcha, S Reaungamornrat, J Goerres, M W Jacobson, S Vogt, G Kleinszig, A J Khanna, J-P Wolinsky, J H Siewerdsen
Decision support to assist in target vertebra localization could provide a useful aid to safe and effective spine surgery. Previous solutions have shown 3D-2D registration of preoperative CT to intraoperative radiographs to reliably annotate vertebral labels for assistance during level localization. We present an algorithm (referred to as MR-LevelCheck) to perform 3D-2D registration based on a preoperative MRI to accommodate the increasingly common clinical scenario in which MRI is used instead of CT for preoperative planning...
January 4, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28049661/height-in-healthy-children-in-low-and-middle-income-countries-an-assessment
#4
Mahesh Karra, S V Subramanian, Günther Fink
BACKGROUND: Despite rapid economic development and reductions in child mortality worldwide, continued high rates of early childhood stunting have put the global applicability of international child-height standards into question. OBJECTIVES: We used population-based survey data to identify children growing up in healthy environments in low- and middle-income countries and compared the height distribution of these children to the height distribution of the reference sample established by the WHO...
January 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28029927/regression-of-glioblastoma-after-chimeric-antigen-receptor-t-cell-therapy
#5
Christine E Brown, Darya Alizadeh, Renate Starr, Lihong Weng, Jamie R Wagner, Araceli Naranjo, Julie R Ostberg, M Suzette Blanchard, Julie Kilpatrick, Jennifer Simpson, Anita Kurien, Saul J Priceman, Xiuli Wang, Todd L Harshbarger, Massimo D'Apuzzo, Julie A Ressler, Michael C Jensen, Michael E Barish, Mike Chen, Jana Portnow, Stephen J Forman, Behnam Badie
A patient with recurrent multifocal glioblastoma received chimeric antigen receptor (CAR)-engineered T cells targeting the tumor-associated antigen interleukin-13 receptor alpha 2 (IL13Rα2). Multiple infusions of CAR T cells were administered over 220 days through two intracranial delivery routes - infusions into the resected tumor cavity followed by infusions into the ventricular system. Intracranial infusions of IL13Rα2-targeted CAR T cells were not associated with any toxic effects of grade 3 or higher...
29, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/28028437/preventing-delayed-diagnosis-of-cancer-clinicians-views-on-main-problems-and-solutions
#6
Lorainne Tudor Car, Nikolaos Papachristou, Catherine Urch, Azeem Majeed, Mona El-Khatib, Paul Aylin, Rifat Atun, Josip Car, Charles Vincent
BACKGROUND: Delayed diagnosis is a major contributing factor to the UK's lower cancer survival compared to many European countries. In the UK, there is a significant national variation in early cancer diagnosis. Healthcare providers can offer an insight into local priorities for timely cancer diagnosis. In this study, we aimed to identify the main problems and solutions relating to delay cancer diagnosis according to cancer care clinicians. METHODS: We developed and implemented a new priority-setting approach called PRIORITIZE and invited North West London cancer care clinicians to identify and prioritize main causes for and solutions to delayed diagnosis of cancer care...
December 2016: Journal of Global Health
https://www.readbyqxmd.com/read/27928379/a-rare-case-of-penetrating-trauma-resulting-in-isolated-third-nerve-palsy
#7
Caleb Story, Michael Patterson, Wilson McWilliams, Bethany Bray Markowitz
A 23-year-old male presented to the emergency department with right eye pain, right upper eyelid ptosis, blurry vision, and binocular diplopia that developed immediately after he bent over in a parking lot and the antenna of a car penetrated his right upper eyelid. An extensive workup was performed, and he was found to have an isolated traumatic oculomotor nerve palsy with pupil involvement. No other ocular findings of a traumatic injury were present. The patient was observed for 14 months, during which he continually improved, with almost complete resolution of his diplopia, anisocoria, and ptosis...
February 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27920797/genome-wide-association-study-for-identifying-loci-that-affect-fillet-yield-carcass-and-body-weight-traits-in-rainbow-trout-oncorhynchus-mykiss
#8
Dianelys Gonzalez-Pena, Guangtu Gao, Matthew Baranski, Thomas Moen, Beth M Cleveland, P Brett Kenney, Roger L Vallejo, Yniv Palti, Timothy D Leeds
Fillet yield (FY, %) is an economically-important trait in rainbow trout aquaculture that affects production efficiency. Despite that, FY has received little attention in breeding programs because it is difficult to measure on a large number of fish and cannot be directly measured on breeding candidates. The recent development of a high-density SNP array for rainbow trout has provided the needed tool for studying the underlying genetic architecture of this trait. A genome-wide association study (GWAS) was conducted for FY, body weight at 10 (BW10) and 13 (BW13) months post-hatching, head-off carcass weight (CAR), and fillet weight (FW) in a pedigreed rainbow trout population selectively bred for improved growth performance...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27908188/polymer-gel-dosimetry-for-measuring-the-dose-near-thin-high-z-materials-irradiated-with-high-energy-photon-beams
#9
Leighton L Warmington, N Gopishankar, John H Broadhurst, Yoichi Watanabe
PURPOSE: To investigate the feasibility of three-dimensional (3D) dose measurements near thin high-Z materials placed in a water-like medium by using a polymer gel dosimeter (PGD) when the medium was irradiated with high energy photon beams. METHODS: PGD is potentially a useful tool for this application because it can record the dose around a small object made of a high-Z material in a continuous 3D medium. In this study, the authors manufactured a methacrylic acid-based normoxic PGD, nMAG...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27900328/blunt-traumatic-tension-chylothorax-case-report-and-mini-review-of-the-literature
#10
Kamal Idris, Michael Sebastian, Ashraf F Hefny, Navidul Haq Khan, Fikri M Abu-Zidan
Tension chylothorax following blunt thoracic trauma is an extremely rare condition. Here we report such a case and review its management. A 31-year-old man was involved in a road traffic collision. The car rolled over and the patient was ejected from the vehicle. On arrival at the Emergency Department the patient was conscious and haemodynamically stable. Clinical examination of the chest and abdomen was normal. The patient had sustained fractures of the sixth cervical vertebra and the tenth thoracic vertebra, left pleural effusion, haematoma around the descending aorta and fracture of the right clavicle...
November 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27887866/continuously-expanding-car-nk-92-cells-display-selective-cytotoxicity-against-b-cell-leukemia-and-lymphoma
#11
Sarah Oelsner, Miriam E Friede, Congcong Zhang, Juliane Wagner, Susanne Badura, Peter Bader, Evelyn Ullrich, Oliver G Ottmann, Hans Klingemann, Torsten Tonn, Winfried S Wels
BACKGROUND AIMS: Natural killer (NK) cells can rapidly respond to transformed and stressed cells and represent an important effector cell type for adoptive immunotherapy. In addition to donor-derived primary NK cells, continuously expanding cytotoxic cell lines such as NK-92 are being developed for clinical applications. METHODS: To enhance their therapeutic utility for the treatment of B-cell malignancies, we engineered NK-92 cells by lentiviral gene transfer to express chimeric antigen receptors (CARs) that target CD19 and contain human CD3ζ (CAR 63...
February 2017: Cytotherapy
https://www.readbyqxmd.com/read/27881148/susceptibility-profile-and-metabolic-mechanisms-involved-in-aedes-aegypti-and-aedes-albopictus-resistant-to-ddt-and-deltamethrin-in-the-central-african-republic
#12
Carine Ngoagouni, Basile Kamgang, Cécile Brengues, Gildas Yahouedo, Christophe Paupy, Emmanuel Nakouné, Mirdad Kazanji, Fabrice Chandre
BACKGROUND: Aedes aegypti and Ae. albopictus are the main epidemic vectors of dengue, chikungunya and Zika viruses worldwide. Their control during epidemics relies mainly on control of larvae and adults with insecticides. Unfortunately, loss of susceptibility of both species to several insecticide classes limits the efficacy of interventions. In Africa, where Aedes-borne viruses are of growing concern, few data are available on resistance to insecticides. To fill this gap, we assessed the susceptibility to insecticides of Ae...
November 24, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27865119/does-haptic-steering-guidance-instigate-speeding-a-driving-simulator-study-into-causes-and-remedies
#13
T Melman, J C F de Winter, D A Abbink
An important issue in road traffic safety is that drivers show adverse behavioral adaptation (BA) to driver assistance systems. Haptic steering guidance is an upcoming assistance system which facilitates lane-keeping performance while keeping drivers in the loop, and which may be particularly prone to BA. Thus far, experiments on haptic steering guidance have measured driver performance while the vehicle speed was kept constant. The aim of the present driving simulator study was to examine whether haptic steering guidance causes BA in the form of speeding, and to evaluate two types of haptic steering guidance designed not to suffer from BA...
January 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27848726/results-from-the-united-states-of-america-s-2016-report-card-on-physical-activity-for-children-and-youth
#14
Peter T Katzmarzyk, Kara D Denstel, Kim Beals, Christopher Bolling, Carly Wright, Scott E Crouter, Thomas L McKenzie, Russell R Pate, Brian E Saelens, Amanda E Staiano, Heidi I Stanish, Susan B Sisson
BACKGROUND: The 2016 United States (U.S.) Report Card on Physical Activity for Children and Youth provides a comprehensive evaluation of physical activity levels and factors influencing physical activity among children and youth. METHODS: The report card includes 10 indicators: Overall Physical Activity, Sedentary Behavior, Active Transportation, Organized Sport Participation, Active Play, Health-related Fitness, Family and Peers, School, Community and the Built Environment, and Government Strategies and Investments...
November 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27816541/pharmacy-services-after-a-tank-car-derailment-and-toxic-chemical-release-in-blount-county-tennessee
#15
Heath Ford, Shane Trent, Stephen Wickizer
OBJECTIVES: To assess the impact of an accidental release of volatilized acrylonitrile on pharmacy services in Blount County, Tennessee. METHODS: A paper questionnaire was mailed to all pharmacies located in Blount County, Tennessee. The questionnaire assessed 5 domains relevant to pharmacy services after the derailment disaster: (1) disaster preparedness, (2) disaster response, (3) disaster information source awareness, (4) Pharmacy Practice Act amendment preference, and (5) pharmacy impact...
January 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/27791220/food-accessibility-and-perceptions-of-shopping-difficulty-among-elderly-people-living-alone-in-japan
#16
M Ishikawa, T Yokoyama, T Nakaya, Y Fukuda, Y Takemi, K Kusama, N Yoshiike, M Nozue, K Yoshiba, N Murayama
OBJECTIVES: This aim of this study was to describe the association between shopping difficulty and food accessibility for elderly people living alone in Japan. DESIGN: A cross-sectoral, multilevel survey was designed to measure shopping difficulty from a food accessibility perspective. The questionnaire was distributed by mail. SETTING: The sample was drawn from seven towns and cities across Japan. PARTICIPANTS: A geographic information system was used to select the sample: it identified the proximity of elderly people living alone to a supermarket...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27789538/at-the-bench-chimeric-antigen-receptor-car-t-cell-therapy-for-the-treatment-of-b-cell-malignancies
#17
REVIEW
Anthony F O Daniyan, Renier J Brentjens
The chimeric antigen receptor (CAR) represents the epitome of cellular engineering and is one of the best examples of rational biologic design of a synthetic molecule. The CAR is a single polypeptide with modular domains, consisting of an antibody-derived targeting moiety, fused in line with T cell-derived signaling domains, allowing for T cell activation upon ligand binding. T cells expressing a CAR are able to eradicate selectively antigen-expressing tumor cells in a MHC-independent fashion. CD19, a tumor-associated antigen (TAA) present on normal B cells, as well as most B cell-derived malignancies, was an early target of this technology...
December 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27785145/cervical-esophageal-rupture-after-blunt-trauma-resulting-from-a-car-accident
#18
Piotr Misiak, Sławomir Jabłoński, Artur Terlecki
Traumatic perforation of the cervical esophagus due to blunt trauma is a very rare condition which continues to be associated with significant mortality rates. The symptoms and signs of this injury are often masked by or ascribed to more common blunt thoracic injuries. This paper presents a case of cervical esophageal perforation secondary to blunt trauma resulting from a car accident. The injury was diagnosed early by computed tomography examination, and the patient underwent prompt and successful surgical repair performed to prevent the development of descending mediastinitis...
September 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/27760864/assessing-mental-models-of-emergencies-through-two-knowledge-elicitation-tasks
#19
Daphne E Whitmer, Valerie K Sims, Michael E Torres
OBJECTIVE: The goals of this study were to assess the risk identification aspect of mental models using standard elicitation methods and how university campus alerts were related to these mental models. BACKGROUND: People fail to follow protective action recommendations in emergency warnings. Past research has yet to examine cognitive processes that influence emergency decision-making. METHOD: Study 1 examined 2 years of emergency alerts distributed by a large southeastern university...
October 19, 2016: Human Factors
https://www.readbyqxmd.com/read/27747556/mortality-from-motorcycle-crashes-the-baby-boomer-cohort-effect
#20
Victor Puac-Polanco, Katherine M Keyes, Guohua Li
BACKGROUND: Motorcyclists are known to be at substantially higher risk per mile traveled of dying from crashes than car occupants. In 2014, motorcycling made up less than 1 % of person-miles traveled but 13 % of the total mortality from motor-vehicle crashes in the United States. We assessed the cohort effect of the baby-boomers (i.e., those born between 1946 and 1964) in motorcycle crash mortality from 1975 to 2014 in the United States. METHODS: Using mortality data for motorcycle occupants from the Fatality Analysis Reporting System, we performed an age-period-cohort analysis using the multiphase method and the intrinsic estimator method...
December 2016: Injury Epidemiology
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