keyword
MENU ▼
Read by QxMD icon Read
search

continuity of car

keyword
https://www.readbyqxmd.com/read/28428885/the-why-what-and-how-of-the-new-fact-standards-for-immune-effector-cells
#1
EDITORIAL
Marcela V Maus, Sarah Nikiforow
Novel cellular therapies outside of traditional hematopoietic stem cell transplantation or hematopoietic progenitor cell (HPC) therapy are currently under evaluation in clinical trials across the United States and around the world. Several cellular products, e.g., CD19-directed Chimeric Antigen Receptor (CAR) T cells, are poised for FDA approval and thus increased use at a wider range of academic centers within the next year, with the likelihood of dissemination to standard oncology practice once safety is confirmed...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28420593/sexual-health-in-the-community-services-for-people-with-intellectual-and-developmental-disabilities
#2
Carli Friedman, Aleksa L Owen
BACKGROUND: Sexuality is a central dimension of overall health and well-being. People with intellectual and developmental disabilities (IDD) continue to experience disparities in healthcare, particularly regarding access to sexual health related services. Medicaid Home and Community-Based Services (HCBS) waivers are ideally situated to provide sexual and reproductive healthcare in accessible settings. OBJECTIVE: This preliminary study analyzed national Medicaid HCBS waivers to determine how they provide sexuality services for people with IDD...
April 6, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28416210/development-of-a-continuous-motorcycle-protection-barrier-system-using-computer-simulation-and-full-scale-crash-testing
#3
Ali O Atahan, J Marten Hiekmann, Jeffrey Himpe, Joseph Marra
Road restraint systems are designed to minimize the undesirable effects of roadside accidents and improve safety of road users. These systems are utilized at either side or median section of roads to contain and redirect errant vehicles. Although restraint systems are mainly designed against car, truck and bus impacts there is an increasing pressure by the motorcycle industry to incorporate motorcycle protection systems into these systems. In this paper development details of a new and versatile motorcycle barrier, CMPS, coupled with an existing vehicle barrier is presented...
April 15, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28416139/cars-synthetic-immunoreceptors-for-cancer-therapy-and-beyond
#4
REVIEW
ZeNan L Chang, Yvonne Y Chen
Chimeric antigen receptors (CARs) are versatile synthetic receptors that provide T cells with engineered specificity. Clinical success in treating B-cell malignancies has demonstrated the therapeutic potential of CAR-T cells against cancer, and efforts are underway to expand the use of engineered T cells to the treatment of diverse medical conditions, including infections and autoimmune diseases. Here, we review current understanding of the molecular properties of CARs, how this knowledge informs the rational design and characterization of novel receptors, the successes and shortcomings of CAR-T cells in the clinic, and emerging solutions for the continued improvement of CAR-T cell therapy...
April 13, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28415196/traffic-gridlock-on-a-honeycomb-city
#5
L E Olmos, J D Muñoz
Inspired by an old and almost in oblivion urban plan, we report the behavior of the Biham-Middleton-Levine (BML) model-a paradigm for studying phase transitions of traffic flow-on a hypothetical city with a perfect honeycomb street network. In contrast with the original BML model on a square lattice, the same model on a honeycomb does not show any anisotropy or intermediate states, but a single continuous phase transition between free and totally congested flow, a transition that can be completely characterized by the tools of classical percolation...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28414178/short-and-long-term-effects-of-risperidone-on-catalepsy-sensitisation-and-acquisition-of-conditioned-avoidance-response-adolescent-vs-adult-rats
#6
Aung Aung Kywe Moe, Gregory A Medely, Timothy Reeks, Thomas H J Burne, Darryl W Eyles
The effects of antipsychotic drugs (APDs) on the adolescent brain are poorly understood despite a dramatic increase in prescription of these drugs in adolescents over the past twenty years. Neuronal systems continue to be remodeled during adolescence. Therefore, when given in adolescence, antipsychotic drugs (APDs) have the potential to affect this remodeling. In this study we investigated the effects of chronic 22-day risperidone treatment (1.3mg/kg/day) in both adolescent and adult rats. We examined short- and long-term changes in behaviour (catalepsy, locomotion and conditioned avoidance response (CAR)), and dopaminergic and serotonergic neurochemistry in the striatum and the nucleus accumbens...
April 13, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28398267/hand-based-gesture-recognition-for-vehicular-applications-using-ir-uwb-radar
#7
Faheem Khan, Seong Kyu Leem, Sung Ho Cho
Modern cars continue to offer more and more functionalities due to which they need a growing number of commands. As the driver tries to monitor the road and the graphic user interface simultaneously, his/her overall efficiency is reduced. In order to reduce the visual attention necessary for monitoring, a gesture-based user interface is very important. In this paper, gesture recognition for a vehicle through impulse radio ultra-wideband (IR-UWB) radar is discussed. The gestures can be used to control different electronic devices inside a vehicle...
April 11, 2017: Sensors
https://www.readbyqxmd.com/read/28385173/novel-augmentation-strategies-in-major-depression
#8
Klaus Martiny
Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28318313/proposal-of-a-calculation-method-to-determine-the-structural-components-contribution-on-the-deceleration-of-a-passenger-compartment-based-on-the-energy-derivative-method
#9
Kei Nagasaka, Koji Mizuno, Daisuke Ito, Naoya Saida
OBJECTIVE: In car crashes, the passenger compartment deceleration significantly influences the occupant loading. Hence, it is important to consider how each structural component deforms in order to control the passenger compartment deceleration. In frontal impact tests, the passenger compartment deceleration depends on the energy absorption property of the front structures. However, at this point in time there are few papers describing the components' quantitative contributions on the passenger compartment deceleration...
March 20, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28318233/assembly-mechanism-of-zr-containing-and-other-tm-containing-polyoxometalates
#10
Pablo Jiménez-Lozano, Albert Solé-Daura, Georges Wipff, Josep M Poblet, Alain Chaumont, Jorge J Carbó
The mechanism by which Zr-substituted and other transition metal-substituted polyoxometalates (POMs) form covalently linked dimers has been analyzed by means of static density functional theory (DFT) calculations with a continuous solvent model as well as Car-Parrinello molecular dynamics (CPMD) simulations with explicit solvent molecules. The study includes different stages of the process: the formation of the active species by alkalination of the solution and formation of intercluster linkages. CPMD simulations show that the Zr-triaqua precursor, [W5O18Zr(H2O)3](2-), under basic conditions, reacts with hydroxide anions to form Zr-aqua-hydroxo active species, [W5O18Zr(OH)(H2O)](3-)...
March 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28288656/incorporation-of-a-hinge-domain-improves-the-expansion-of-chimeric-antigen-receptor-t-cells
#11
Le Qin, Yunxin Lai, Ruocong Zhao, Xinru Wei, Jianyu Weng, Peilong Lai, Baiheng Li, Simiao Lin, Suna Wang, Qiting Wu, Qiubin Liang, Yangqiu Li, Xuchao Zhang, Yilong Wu, Pentao Liu, Yao Yao, Duanqing Pei, Xin Du, Peng Li
BACKGROUND: Multiple iterations of chimeric antigen receptors (CARs) have been developed, mainly focusing on intracellular signaling modules. However, the effect of non-signaling extracellular modules on the expansion and therapeutic efficacy of CARs remains largely undefined. METHODS: We generated two versions of CAR vectors, with or without a hinge domain, targeting CD19, mesothelin, PSCA, MUC1, and HER2, respectively. Then, we systematically compared the effect of the hinge domains on the growth kinetics, cytokine production, and cytotoxicity of CAR T cells in vitro and in vivo...
March 13, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28267120/pressure-mapping-in-elderly-care-a-tool-to-increase-pressure-injury-knowledge-and-awareness-among-staff
#12
Lisa Hultin, Estrid Olsson, Cheryl Carli, Lena Gunningberg
PURPOSE: The purpose of this study was to evaluate the use of a pressure mapping system with real-time feedback of pressure points in elderly care, with specific focus on pressure injury (PI) knowledge/attitudes (staff), interface pressure, and PI prevention activities (residents). DESIGN: Descriptive, 1-group pretest/posttest study. SUBJECTS AND SETTING: A convenience sample of 40 assistant nurses and aides participated in the study; staff members were recruited at daytime, and 1 nighttime meeting was held at the facility...
March 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28244858/the-assessment-and-appraisal-of-regenerative-medicines-and-cell-therapy-products-an-exploration-of-methods-for-review-economic-evaluation-and-appraisal
#13
Robert Hettle, Mark Corbett, Sebastian Hinde, Robert Hodgson, Julie Jones-Diette, Nerys Woolacott, Stephen Palmer
BACKGROUND: The National Institute for Health and Care Excellence (NICE) commissioned a 'mock technology appraisal' to assess whether changes to its methods and processes are needed. This report presents the findings of independent research commissioned to inform this appraisal and the deliberations of a panel convened by NICE to evaluate the mock appraisal. METHODS: Our research included reviews to identify issues, analysis methods and conceptual differences and the relevance of alternative decision frameworks, alongside the development of an exemplar case study of chimeric antigen receptor (CAR) T-cell therapy for treating acute lymphoblastic leukaemia...
February 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28215244/driving-home-from-the-night-shift-a-bright-light-intervention-study
#14
Denise M Weisgerber, Maria Nikol, Ralph E Mistlberger
Sleep deprivation (SD) impairs vigilance and increases the risk of driving accidents during the commute home after night work. Bright light (BL) can enhance alertness and cognitive performance. We examined the effects of BL (5600 lux) versus dim light (DL, 35 lux) at the end of a night awake on driving performance. METHODS: Subjects (N = 19, 22.8 ± 4 ya) completed three conditions, counterbalanced for order at >1 week intervals. The two overnight SD conditions began in the lab at usual bedtime...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215040/who-should-receive-a-transplant-for-acute-lymphoblastic-leukaemia
#15
REVIEW
Rishi Dhawan, David I Marks
Allogeneic haematopoietic cell transplantation continues to be an important curative therapy for acute lymphoblastic leukaemia (ALL). Traditionally accepted indications for allografting adult ALL patients need reevaluation in light of outcomes with paediatric-like intensive regimens. Minimal residual disease status and oncogenetics can be used for restratification of standard risk patients. A greater body of data on haematopoietic cell transplantation (HCT) outcomes from haploidentical and cord blood donor sources has been generated in recent years...
February 18, 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/28202239/vehicle-emission-trends-in-china-s-guangdong-province-from-1994-to-2014
#16
Yong-Hong Liu, Wen-Yuan Liao, Li Li, Yu-Ting Huang, Wei-Jia Xu
Exploring vehicle emission trends within and outside the Pearl River Delta (PRD) region during a long period was scientific and practical, for the economic rapid unbalanced development, continuous implements of severe reducing vehicle emissions measures in Guangdong province. Multi-year inventories of vehicle emissions from 1994 to 2014 were estimated based on the emissions factors of different emissions standards and vehicle kilometers travelled for all types of vehicles. The trends and characteristics of the emissions of carbon monoxide (CO), volatile organic compounds (VOCs), nitrogen oxides (NOx), fine particulate matter (PM2...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28153859/dlbcl-responds-well-to-anti-cd19-car-therapy
#17
(no author information available yet)
According to an interim analysis of phase II data from a study of the anti-CD19 chimeric antigen receptor T-cell therapy KTE-C19, 76% of 51 patients with diffuse large B-cell lymphoma responded to the treatment; 47% had a complete response. After 3 months, 33% continued to experience a complete response.
March 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28153743/acceptability-of-virtual-prenatal-visits-for-women-with-gestational-diabetes
#18
Teresa N Harrison, David A Sacks, Carly Parry, Mayra Macias, Deborah S Ling Grant, Jean M Lawrence
INTRODUCTION: Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy. Current approaches to GDM management and education are labor intensive and costly. Telemedicine offers a potential solution to reduce the time and cost burden of prenatal care for women with GDM. METHODS: We assessed the acceptability of a telemedicine intervention to transmit patients' weight, blood pressure, and blood glucose measurements from wireless devices to health care providers, and to alternate "virtual office visits" with office-based prenatal visits...
January 30, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28151837/pressure-mapping-in-elderly-care-a-tool-to-increase-pressure-injury-knowledge-and-awareness-among-staff
#19
Lisa Hultin, Estrid Olsson, Cheryl Carli, Lena Gunningberg
PURPOSE: The purpose of this study was to evaluate the use of a pressure mapping system with real-time feedback of pressure points in elderly care, with specific focus on pressure injury (PI) knowledge/attitudes (staff), interface pressure, and PI prevention activities (residents). DESIGN: Descriptive, 1-group pretest/posttest study. SUBJECTS AND SETTING: A convenience sample of 40 assistant nurses and aides participated in the study; staff members were recruited at daytime, and 1 nighttime meeting was held at the facility...
February 1, 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28151783/organizational-learning-in-a-cardiac-intensive-care-unit-a-learning-history
#20
Bret Lyman, Kalene M Ethington, Carly King, Jonathan D Jacobs, Hayley Lundeen
INTRODUCTION: Providing high-quality care to every patient is challenging, particularly in critical care units (CCUs). However, this standard can be achieved through organizational learning. Unfortunately, the process of organizational learning in CCUs is not well understood. OBJECTIVE: The objective of this study is to describe the developmental progression of a cardiac intensive care unit (CICU) to reach its current state of reliably excellent clinical performance...
March 2017: Dimensions of Critical Care Nursing: DCCN
keyword
keyword
69291
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"