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https://www.readbyqxmd.com/read/29326190/a-qualitative-study-of-patients-feedback-about-outpatient-parenteral-antimicrobial-therapy-opat-services-in-northern-england-implications-for-service-improvement
#1
Maureen Twiddy, Carolyn J Czoski Murray, Samantha J Mason, David Meads, Judy M Wright, Elizabeth D Mitchell, Jane Minton
OBJECTIVE: Outpatient parenteral antimicrobial therapy (OPAT) provides opportunities for improved cost savings, but in the UK, implementation is patchy and a variety of service models are in use. The slow uptake in the UK and Europe is due to a number of clinical, financial and logistical issues, including concern about patient safety. The measurement of patient experience data is commonly used to inform commissioning decisions, but these focus on functional aspects of services and fail to examine the relational aspects of care...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29310899/efficacy-safety-and-tolerability-of-dolutegravir-rilpivirine-for-the-maintenance-of-virological-suppression-in-adults-with-hiv-1-phase-3-randomised-non-inferiority-sword-1-and-sword-2-studies
#2
Josep M Llibre, Chien-Ching Hung, Cynthia Brinson, Francesco Castelli, Pierre-Marie Girard, Lesley P Kahl, Elizabeth A Blair, Kostas Angelis, Brian Wynne, Kati Vandermeulen, Mark Underwood, Kim Smith, Martin Gartland, Michael Aboud
BACKGROUND: Lifelong HIV antiretroviral therapy (ART) has prompted an interest in two-drug regimens to minimise cumulative drug exposure and toxicities. The safety, tolerability, and efficacy of dolutegravir and rilpivirine suggest potential compatibility and effectiveness as a two-drug regimen. We aimed to investigate this two-drug regimen in a phase 3 study. METHODS: We identically designed SWORD-1 and SWORD-2, which were open-label, parallel-group, multicentre, phase 3, randomised, non-inferiority studies in 12 countries evaluating efficacy and safety of once-daily dolutegravir 50 mg plus rilpivirine 25 mg versus current ART regimen (CAR)...
January 5, 2018: Lancet
https://www.readbyqxmd.com/read/29290595/the-media-response-to-the-acgme-s-2017-relaxed-resident-duty-hour-restrictions
#3
Zi Zhang, Alan V Krauthamer, Andrew B Rosenkrantz
PURPOSE: In March 2017, the ACGME relaxed resident duty-hour restrictions to allow first-year residents to work 24-hour shifts, affecting the internship experience of incoming radiology residents. The aim of this study was to assess the media response to this duty-hour change, comparing news articles with favorable and unfavorable views. METHODS: Google News was used to identify 36 relevant unique news articles published over a 4-week period after the announcement...
December 28, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29280183/semiparametric-bayesian-models-for-evaluating-time-variant-driving-risk-factors-using-naturalistic-driving-data-and-case-crossover-approach
#4
Feng Guo, Inyong Kim, Sheila G Klauer
Driver behavior is a major contributing factor for traffic crashes, a leading cause of death and injury in the United States. The naturalistic driving study (NDS) revolutionizes driver behavior research by using sophisticated nonintrusive in-vehicle instrumentation to continuously record driving data. This paper uses a case-crossover approach to evaluate driver-behavior risk. To properly model the unbalanced and clustered binary outcomes, we propose a semiparametric hierarchical mixed-effect model to accommodate both among-strata and within-stratum variations...
December 26, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29274792/the-personal-outcome-measures%C3%A2
#5
Carli Friedman
BACKGROUND: The Personal Outcome Measures® is a person-centered tool to measure the quality of life (QOL) of people with disabilities, especially those who receive long term services and supports. While the outcomes examine people's satisfaction with their lives in a wide range of areas, the organizational supports determine if service agencies are appropriately supporting people with disabilities to ensure people with disabilities have the best possible QOL. The Personal Outcome Measures® has been administered to tens of thousands of people with disabilities and older adults over its twenty-five years of existence...
December 13, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/29258245/integrating-norm-activation-model-and-theory-of-planned-behavior-to-understand-sustainable-transport-behavior-evidence-from-china
#6
Yuwei Liu, Hong Sheng, Norbert Mundorf, Colleen Redding, Yinjiao Ye
With increasing urbanization in China, many cities are facing serious environmental problems due to continuous and substantial increase in automobile transportation. It is becoming imperative to examine effective ways to reduce individual automobile use to facilitate sustainable transportation behavior. Empirical, theory-based research on sustainable transportation in China is limited. In this research, we propose an integrated model based on the norm activation model and the theory of planned behavior by combining normative and rational factors to predict individuals' intention to reduce car use...
December 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29248618/understanding-international-road-safety-disparities-why-is-australia-so-much-safer-than-the-united-states
#7
Wesley E Marshall
Despite similarities to the US in terms of transportation, land use, and culture, Australia kills 5.3 people per 100,000 population on the roads each year, as compared to the US rate of 12.4. Similar trends hold when accounting for distance driven and the number of registered cars. This paper seeks to understand what is behind the road safety disparities between these two countries. The results suggest that a number of inter-related factors seem to play a role in the better road safety outcomes of Australia as compared to the US...
December 14, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29226797/axicabtagene-ciloleucel-car-t-cell-therapy-in-refractory-large-b-cell-lymphoma
#8
Sattva S Neelapu, Frederick L Locke, Nancy L Bartlett, Lazaros J Lekakis, David B Miklos, Caron A Jacobson, Ira Braunschweig, Olalekan O Oluwole, Tanya Siddiqi, Yi Lin, John M Timmerman, Patrick J Stiff, Jonathan W Friedberg, Ian W Flinn, Andre Goy, Brian T Hill, Mitchell R Smith, Abhinav Deol, Umar Farooq, Peter McSweeney, Javier Munoz, Irit Avivi, Januario E Castro, Jason R Westin, Julio C Chavez, Armin Ghobadi, Krishna V Komanduri, Ronald Levy, Eric D Jacobsen, Thomas E Witzig, Patrick Reagan, Adrian Bot, John Rossi, Lynn Navale, Yizhou Jiang, Jeff Aycock, Meg Elias, David Chang, Jeff Wiezorek, William Y Go
Background In a phase 1 trial, axicabtagene ciloleucel (axi-cel), an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, showed efficacy in patients with refractory large B-cell lymphoma after the failure of conventional therapy. Methods In this multicenter, phase 2 trial, we enrolled 111 patients with diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, or transformed follicular lymphoma who had refractory disease despite undergoing recommended prior therapy. Patients received a target dose of 2×106 anti-CD19 CAR T cells per kilogram of body weight after receiving a conditioning regimen of low-dose cyclophosphamide and fludarabine...
December 10, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29219092/systematic-review-of-the-relationships-between-sedentary-behaviour-and-health-indicators-in-the-early-years-0-4%C3%A2-years
#9
Veronica J Poitras, Casey E Gray, Xanne Janssen, Salome Aubert, Valerie Carson, Guy Faulkner, Gary S Goldfield, John J Reilly, Margaret Sampson, Mark S Tremblay
BACKGROUND: The purpose of this systematic review was to examine the relationships between sedentary behaviour (SB) and health indicators in children aged 0 to 4 years, and to determine what doses of SB (i.e., duration, patterns [frequency, interruptions], and type) were associated with health indicators. METHODS: Online databases were searched for peer-reviewed studies that met the a priori inclusion criteria: population (apparently healthy, 1 month to 4.99 years), intervention/exposure and comparator (durations, patterns, and types of SB), and outcome/health indicator (critical: adiposity, motor development, psychosocial health, cognitive development; important: bone and skeletal health, cardiometabolic health, fitness, risks/harm)...
November 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29213234/cognitive-mapping-based-on-conjunctive-representations-of-space-and-movement
#10
Taiping Zeng, Bailu Si
It is a challenge to build robust simultaneous localization and mapping (SLAM) system in dynamical large-scale environments. Inspired by recent findings in the entorhinal-hippocampal neuronal circuits, we propose a cognitive mapping model that includes continuous attractor networks of head-direction cells and conjunctive grid cells to integrate velocity information by conjunctive encodings of space and movement. Visual inputs from the local view cells in the model provide feedback cues to correct drifting errors of the attractors caused by the noisy velocity inputs...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/29212820/vision-in-former-very-low-birthweight-young-adults-with-and-without-retinopathy-of-prematurity-compared-with-term-born-controls-the-nz-1986-vlbw-follow-up-study
#11
Brian A Darlow, Mark J Elder, Bridget Kimber, Julia Martin, L John Horwood
OBJECTIVE: There are few data on visual outcomes in adulthood of former very low birthweight (VLBW; <1500 g) infants. We aimed to assess vision at 27-29 years in a national cohort of VLBW infants born in 1986 and assessed for retinopathy of prematurity (ROP) when no treatment was available, compared with term born controls. METHODS: The cohort and controls attended a 2-day assessment in Christchurch as part of a larger study. Visual assessment included glasses prescription measured by focimeter, logarithm of the minimum angle of resolution (logMAR) distance visual acuity (VA), contrast sensitivity, autorefraction, retinal photographs and a questionnaire on vision-related everyday activities...
December 6, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29211510/forced-desynchronization-model-for-a-diurnal-primate
#12
Crhistiane A Silva, Laís I M Melo, Alina R Pires, Jordana C Barbalho, Andreia V Melo, Diego A C Fernandes, Everly B Oliveira, Carolina V M Azevedo, Trinitat Cambras, Antoni Díez-Noguera, John Fontenele-Araujo
The circadian system is organized in a hierarchy of multiple oscillators, with the suprachiasmatic nucleus (SCN) as the master oscillator in mammals. The SCN is formed by a group of coupled cell oscillators. Knowledge of this coupling mechanism is essential to understanding entrainment and the expression of circadian rhythms. Some authors suggest that light-dark (LD) cycles with periods near the limit of entrainment may be good models for promoting internal desynchronization, providing knowledge about the coupling mechanism...
December 6, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29203024/rage-against-the-machine-google-s-self-driving-cars-versus-human-drivers
#13
Eric R Teoh, David G Kidd
INTRODUCTION: Automated driving represents both challenges and opportunities in highway safety. Google has been developing self-driving cars and testing them under employee supervision on public roads since 2009. These vehicles have been involved in several crashes, and it is of interest how this testing program compares to human drivers in terms of safety. METHODS: Google car crashes were coded by type and severity based on narratives released by Google. Crash rates per million vehicle miles traveled (VMT) were computed for crashes deemed severe enough to be reportable to police...
December 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/29189429/new-developments-in-immunotherapy-for-pediatric-solid-tumors
#14
Liora M Schultz, Robbie Majzner, Kara L Davis, Crystal Mackall
PURPOSE OF REVIEW: Building upon preclinical advances, we are uncovering immunotherapy strategies that are translating into improved outcomes in tumor subsets. Advanced pediatric solid tumors carry poor prognoses and resultant robust efforts to apply immunotherapy advances to pediatric solid tumors are in progress. Here, we discuss recent developments in the field using mAb and mAb-based therapies including checkpoint blockade and chimeric antigen receptors (CARs). RECENT FINDINGS: The pediatric solid tumor mAb experience targeting the diganglioside, GD2, for patients with neuroblastoma has been the most compelling to date...
November 20, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29182589/radio-frequency-controlled-urea-dosing-for-nh%C3%A2-scr-catalysts-nh%C3%A2-storage-influence-to-catalyst-performance-under-transient-conditions
#15
Markus Dietrich, Gunter Hagen, Willibald Reitmeier, Katharina Burger, Markus Hien, Philippe Grass, David Kubinski, Jaco Visser, Ralf Moos
Current developments in exhaust gas aftertreatment led to a huge mistrust in diesel driven passenger cars due to their NOx emissions being too high. The selective catalytic reduction (SCR) with ammonia (NH₃) as reducing agent is the only approach today with the capability to meet upcoming emission limits. Therefore, the radio-frequency-based (RF) catalyst state determination to monitor the NH₃ loading on SCR catalysts has a huge potential in emission reduction. Recent work on this topic proved the basic capability of this technique under realistic conditions on an engine test bench...
November 28, 2017: Sensors
https://www.readbyqxmd.com/read/29176353/new-developments-in-immunotherapy-for-pediatric-leukemia
#16
Jessica B Foster, Shannon L Maude
PURPOSE OF REVIEW: Immunotherapy for the treatment of cancer has advanced at a tremendous pace over the last decade. In this review, we provide an overview of recent progress in immunotherapy for the treatment of leukemia, focusing on antibody-drug conjugates (ADC), bi-specific T-cell engagers (BiTE), and chimeric antigen receptor (CAR) T cells. RECENT FINDINGS: Ongoing clinical trials of CAR T cells directed against CD19 have produced complete remission rates as high as 93%, prompting global multicenter phase 2 trials and the first FDA approval of a CAR T-cell therapy...
February 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29172092/visual-field-defects-after-temporal-lobe-resection-for-epilepsy
#17
Alvilda T Steensberg, Ane Sophie Olsen, Minna Litman, Bo Jespersen, Miriam Kolko, Lars H Pinborg
PURPOSE: To determine visual field defects (VFDs) using methods of varying complexity and compare results with subjective symptoms in a population of newly operated temporal lobe epilepsy patients. METHODS: Forty patients were included in the study. Two patients failed to perform VFD testing. Humphrey Field Analyzer (HFA) perimetry was used as the gold standard test to detect VFDs. All patients performed a web-based visual field test called Damato Multifixation Campimetry Online (DMCO)...
November 20, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29164618/analysis-of-erythemal-uvb-dose-received-inside-a-car-in-valencia-spain
#18
Gonzalo Gurrea Ysasi, Vicente Blanca Giménez, Juan Carlos Moreno, MªAntonia Serrano
Continuous exposures to ultraviolet radiation can lead to harmful effects on human skin. Professional drivers may spend more than 8 hours per day inside a vehicle. This paper describes an analysis of the UVER (erythemal ultraviolet radiation) received by a driver and passenger inside a vehicle. A 3-door Peugeot 206 was used for the study. VioSpor Blue Line dosimeters (with a response profile close to that of human skin) were used to measure the erythematic dose of UV radiation (able to produce erythema on human skin)...
November 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29163083/effective-connectivity-analysis-of-the-brain-network-in-drivers-during-actual-driving-using-near-infrared-spectroscopy
#19
Zhian Liu, Ming Zhang, Gongcheng Xu, Congcong Huo, Qitao Tan, Zengyong Li, Quan Yuan
Driving a vehicle is a complex activity that requires high-level brain functions. This study aimed to assess the change in effective connectivity (EC) between the prefrontal cortex (PFC), motor-related areas (MA) and vision-related areas (VA) in the brain network among the resting, simple-driving and car-following states. Twelve young male right-handed adults were recruited to participate in an actual driving experiment. The brain delta [HbO2] signals were continuously recorded using functional near infrared spectroscopy (fNIRS) instruments...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29153449/the-changing-epidemiology-of-open-fractures-in-vehicle-occupants-pedestrians-motorcyclists-and-cyclists
#20
Dennis Winkler, Stuart T Goudie, Charles M Court-Brown
AIMS: To investigate the changing epidemiology of open fractures in vehicle occupants, pedestrians, motorcyclists and cyclists. MATERIALS AND METHODS: Data on all non-spinal open fractures admitted to the Royal Infirmary of Edinburgh after a road traffic accident between 1988 and 2010 were collected and analysed to provide information about the changing epidemiology in different patient groups. Demographic information was collected on all patients with the severity of injury being analysed with the Injury Severity Score (ISS), Musculoskeletal Index (MSI) and the number of open fractures...
November 14, 2017: Injury
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