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https://www.readbyqxmd.com/read/28529012/the-epidemiology-and-hotspots-of-road-traffic-injuries-in-moshi-tanzania-an-observational-study
#1
Joseph M Reardon, Luciano Andrade, Julian Hertz, George Kiwango, Anneth Teu, Msafiri Pesambili, Deena El-Gabri, Michael Hocker, Mark Mvungi, João Ricardo N Vissoci, Catherine A Staton
Road traffic injuries (RTIs) continue to increase with the proliferation of motor vehicles, especially in low-income countries where safe road infrastructure is lacking. Knowing where and why RTIs occur would allow for increased safety and prevention planning. In this study, police records of 300 motor vehicle collisions which occurred between February 2013 and January 2014 in Moshi, Tanzania were reviewed. Analysis of variables including victim age, gender, type of collision, conditions, and use of safety equipment were analyzed...
May 3, 2017: Injury
https://www.readbyqxmd.com/read/28515942/a-tandem-cd19-cd20-car-lentiviral-vector-drives-on-target-and-off-target-antigen-modulation-in-leukemia-cell-lines
#2
Dina Schneider, Ying Xiong, Darong Wu, Volker Nӧlle, Sarah Schmitz, Waleed Haso, Andrew Kaiser, Boro Dropulic, Rimas J Orentas
BACKGROUND: Clinical success with chimeric antigen receptor (CAR)- based immunotherapy for leukemia has been accompanied by the associated finding that antigen-escape variants of the disease are responsible for relapse. To target hematologic malignancies with a chimeric antigen receptor (CAR) that targets two antigens with a single vector, and thus potentially lessen the chance of leukemic escape mutations, a tandem-CAR approach was investigated. METHODS: Antigen binding domains from the FMC63 (anti-CD19) and Leu16 (anti-CD20) antibodies were linked in differing configurations to transmembrane and T cell signaling domains to create tandem-CARs...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28473427/erg-and-oct-findings-of-a-patient-with-a-clinical-diagnosis-of-occult-macular-dystrophy-in-a-patient-of-ashkenazi-jewish-descent-associated-with-a-novel-mutation-in-the-gene-encoding-rp1l1
#3
Norman Saffra, Carly Jane Seidman, Aleksandr Rakhamimov, Stephen H Tsang
A 57-year-old man with a past medical history of diabetes presented for consultation with a several year history of slowly progressive vision loss in both eyes, which continued to deteriorate over 7 years of follow-up. Multimodal imaging was performed and was significant for the following: on spectral domain optical coherence tomography, a gap lesion was present in the ellipsoid layer, beneath the umbo, as well as subtle macular changes on auto fluorescence imaging. Multifocal electroretinography was performed and was abnormal, and a clinical diagnosis of occult macular dystrophy was made...
May 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28469673/understanding-public-views-about-air-quality-and-air-pollution-sources-in-the-san-joaquin-valley-california
#4
Ricardo Cisneros, Paul Brown, Linda Cameron, Erin Gaab, Mariaelena Gonzalez, Steven Ramondt, David Veloz, Anna Song, Don Schweizer
The San Joaquin Valley of California has poor air quality and high rates of asthma. Surveys were collected from 744 residents of the San Joaquin Valley from November 2014 to January 2015 to examine the public's views about air quality. The results of this study suggest that participants exposed to high PM2.5 (particulate matter less than 2.5 microns in size) concentrations perceived air pollution to be of the worst quality. Air quality in the San Joaquin Valley was primarily perceived as either moderate or unhealthy for sensitive groups...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28461637/dental-students-perceptions-of-digital-assessment-software-for-preclinical-tooth-preparation-exercises
#5
Carly F Park, Justin M Sheinbaum, Yasushi Tamada, Raina Chandiramani, Lisa Lian, Cliff Lee, John Da Silva, Shigemi Ishikawa-Nagai
Objective self-assessment is essential to learning and continued competence in dentistry. A computer-assisted design/computer-assisted manufacturing (CAD/CAM) learning software (prepCheck, Sirona) allows students to objectively assess their performance in preclinical prosthodontics. The aim of this study was to evaluate students' perceptions of CAD/CAM learning software for preclinical prosthodontics exercises. In 2014, all third-year dental students at Harvard School of Dental Medicine (n=36) were individually instructed by a trained faculty member in using prepCheck...
May 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28455198/residence-at-moderate-versus-low-altitude-is-effective-at-maintaining-higher-oxygen-saturation-during-exercise-and-reducing-acute-mountain-sickness-following-fast-ascent-to-4559-m
#6
Eva Bernardi, Luca Pomidori, Davide Cavallari, Gaia Mandolesi, Annalisa Cogo
OBJECTIVE: To continuously monitor oxygen saturation (SpO2) by pulse oximeter and assess the development of acute mountain sickness (AMS) using the Lake Louise Score (LLS) during ascent from 1154 to 4559 m in 2 groups of subjects: 10 moderate-altitude residents (MAR; ≥1000-≤2500 m) and 34 low-altitude residents (LAR). MAR are reported to have a lower incidence of AMS during ascent to higher altitudes compared with LAR. Whether this is related to higher SpO2 is still open to debate...
April 25, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28453402/evaluation-of-carbon-emission-reductions-promoted-by-private-driving-restrictions-based-on-afc-data-in-beijing
#7
Wandi Zhang, Feng Chen, Zijia Wang, Jianling Huang, Bo Wang
Public transportation automatic fare collection (AFC) systems are able to continuously record large amounts of passenger travel information, providing massive, low-cost data for research on regulations pertaining to public transport. This data can be used not only to analyze characteristics of passengers' trips but also to evaluate transport policies that promote a travel mode shift and emission reduction. In this study, models combining card, survey, and GIS data are established with a research focus on the private driving restriction policies being implemented in an ever-increasing number of cities...
April 28, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28443082/inbred-mouse-populations-exhibit-intergenerational-changes-in-intestinal-microbiota-composition-and-function-following-introduction-to-a-facility
#8
Jocelyn M Choo, Paul J Trim, Lex E X Leong, Guy C J Abell, Carly Brune, Nicole Jeffries, Steve Wesselingh, T N Dear, Marten F Snel, Geraint B Rogers
Inbred mice are used to investigate many aspects of human physiology, including susceptibility to disease and response to therapies. Despite increasing evidence that the composition and function of the murine intestinal microbiota can substantially influence a broad range of experimental outcomes, relatively little is known about microbiome dynamics within experimental mouse populations. We investigated changes in the intestinal microbiome between C57BL/6J mice spanning six generations (assessed at generations 1, 2, 3, and 6), following their introduction to a stringently controlled facility...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28441909/the-perceived-quality-of-in-vehicle-auditory-signals-a-structural-equation-modelling-approach
#9
Chia-Fen Chi, Ratna Sari Dewi, Yopie Yutama Surbakti, Dong-Yu Hsieh
The current study applied Structural Equation Modelling to analyse the relationship among pitch, loudness, tempo and timbre and their relationship with perceived sound quality. Twenty-eight auditory signals of horn, indicator, door open warning and parking sensor were collected from 11 car brands. Twenty-one experienced drivers were recruited to evaluate all sound signals with 11 semantic differential scales. The results indicate that for the continuous sounds, pitch, loudness and timbre each had a direct impact on the perceived quality...
May 5, 2017: Ergonomics
https://www.readbyqxmd.com/read/28441906/setting-priorities-for-eu-healthcare-workforce-it-skills-competence-improvement
#10
Sisi Li, Panagiotis D Bamidis, Stathis Th Konstantinidis, Vicente Traver, Josip Car, Nabil Zary
A major challenge for healthcare quality improvement is the lack of IT skills and knowledge of healthcare workforce, as well as their ambivalent attitudes toward IT. This article identifies and prioritizes actions needed to improve the IT skills of healthcare workforce across the EU. A total of 46 experts, representing different fields of expertise in healthcare and geolocations, systematically listed and scored actions that would improve IT skills among healthcare workforce. The Child Health and Nutrition Research Initiative methodology was used for research priority-setting...
April 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/28439067/perfluorooctanesulfonate-pfos-induced-sertoli-cell-injury-through-a-disruption-of-f-actin-and-microtubule-organization-is-mediated-by-akt1-2
#11
Ying Gao, Haiqi Chen, Xiang Xiao, Wing-Yee Lui, Will M Lee, Dolores D Mruk, C Yan Cheng
PFOS (perfluorooctanesulfonate, or perfluorooctane sulfonic acid) is an anthropogenic fluorosurfactant widely used in consumer products. While its use in Europe, Canada and the U.S. has been banned due to its human toxicity, it continues to be used in China and other developing countries as a global pollutant. Herein, using an in vitro model of Sertoli cell blood-testis barrier (BTB), PFOS was found to induce Sertoli cell injury by perturbing actin cytoskeleton through changes in the spatial expression of actin regulatory proteins...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428885/the-why-what-and-how-of-the-new-fact-standards-for-immune-effector-cells
#12
EDITORIAL
Marcela V Maus, Sarah Nikiforow
Novel cellular therapies outside of traditional hematopoietic stem cell transplantation or hematopoietic progenitor cell (HPC) therapy are currently under evaluation in clinical trials across the United States and around the world. Several cellular products, e.g., CD19-directed Chimeric Antigen Receptor (CAR) T cells, are poised for FDA approval and thus increased use at a wider range of academic centers within the next year, with the likelihood of dissemination to standard oncology practice once safety is confirmed...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28420593/sexual-health-in-the-community-services-for-people-with-intellectual-and-developmental-disabilities
#13
Carli Friedman, Aleksa L Owen
BACKGROUND: Sexuality is a central dimension of overall health and well-being. People with intellectual and developmental disabilities (IDD) continue to experience disparities in healthcare, particularly regarding access to sexual health related services. Medicaid Home and Community-Based Services (HCBS) waivers are ideally situated to provide sexual and reproductive healthcare in accessible settings. OBJECTIVE: This preliminary study analyzed national Medicaid HCBS waivers to determine how they provide sexuality services for people with IDD...
April 6, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28416210/development-of-a-continuous-motorcycle-protection-barrier-system-using-computer-simulation-and-full-scale-crash-testing
#14
Ali O Atahan, J Marten Hiekmann, Jeffrey Himpe, Joseph Marra
Road restraint systems are designed to minimize the undesirable effects of roadside accidents and improve safety of road users. These systems are utilized at either side or median section of roads to contain and redirect errant vehicles. Although restraint systems are mainly designed against car, truck and bus impacts there is an increasing pressure by the motorcycle industry to incorporate motorcycle protection systems into these systems. In this paper development details of a new and versatile motorcycle barrier, CMPS, coupled with an existing vehicle barrier is presented...
April 15, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28416139/cars-synthetic-immunoreceptors-for-cancer-therapy-and-beyond
#15
REVIEW
ZeNan L Chang, Yvonne Y Chen
Chimeric antigen receptors (CARs) are versatile synthetic receptors that provide T cells with engineered specificity. Clinical success in treating B-cell malignancies has demonstrated the therapeutic potential of CAR-T cells against cancer, and efforts are underway to expand the use of engineered T cells to the treatment of diverse medical conditions, including infections and autoimmune diseases. Here, we review current understanding of the molecular properties of CARs, how this knowledge informs the rational design and characterization of novel receptors, the successes and shortcomings of CAR-T cells in the clinic, and emerging solutions for the continued improvement of CAR-T cell therapy...
May 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28415196/traffic-gridlock-on-a-honeycomb-city
#16
L E Olmos, J D Muñoz
Inspired by an old and almost in oblivion urban plan, we report the behavior of the Biham-Middleton-Levine (BML) model-a paradigm for studying phase transitions of traffic flow-on a hypothetical city with a perfect honeycomb street network. In contrast with the original BML model on a square lattice, the same model on a honeycomb does not show any anisotropy or intermediate states, but a single continuous phase transition between free and totally congested flow, a transition that can be completely characterized by the tools of classical percolation...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28414178/short-and-long-term-effects-of-risperidone-on-catalepsy-sensitisation-and-acquisition-of-conditioned-avoidance-response-adolescent-vs-adult-rats
#17
Aung Aung Kywe Moe, Gregory A Medely, Timothy Reeks, Thomas H J Burne, Darryl W Eyles
The effects of antipsychotic drugs (APDs) on the adolescent brain are poorly understood despite a dramatic increase in prescription of these drugs in adolescents over the past twenty years. Neuronal systems continue to be remodeled during adolescence. Therefore, when given in adolescence, antipsychotic drugs (APDs) have the potential to affect this remodeling. In this study we investigated the effects of chronic 22-day risperidone treatment (1.3mg/kg/day) in both adolescent and adult rats. We examined short- and long-term changes in behaviour (catalepsy, locomotion and conditioned avoidance response (CAR)), and dopaminergic and serotonergic neurochemistry in the striatum and the nucleus accumbens...
April 13, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28398267/hand-based-gesture-recognition-for-vehicular-applications-using-ir-uwb-radar
#18
Faheem Khan, Seong Kyu Leem, Sung Ho Cho
Modern cars continue to offer more and more functionalities due to which they need a growing number of commands. As the driver tries to monitor the road and the graphic user interface simultaneously, his/her overall efficiency is reduced. In order to reduce the visual attention necessary for monitoring, a gesture-based user interface is very important. In this paper, gesture recognition for a vehicle through impulse radio ultra-wideband (IR-UWB) radar is discussed. The gestures can be used to control different electronic devices inside a vehicle...
April 11, 2017: Sensors
https://www.readbyqxmd.com/read/28385173/novel-augmentation-strategies-in-major-depression
#19
Klaus Martiny
Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28318313/proposal-of-a-calculation-method-to-determine-the-structural-components-contribution-on-the-deceleration-of-a-passenger-compartment-based-on-the-energy-derivative-method
#20
Kei Nagasaka, Koji Mizuno, Daisuke Ito, Naoya Saida
OBJECTIVE: In car crashes, the passenger compartment deceleration significantly influences the occupant loading. Hence, it is important to consider how each structural component deforms in order to control the passenger compartment deceleration. In frontal impact tests, the passenger compartment deceleration depends on the energy absorption property of the front structures. However, at this point in time there are few papers describing the components' quantitative contributions on the passenger compartment deceleration...
March 20, 2017: Traffic Injury Prevention
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