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https://www.readbyqxmd.com/read/28810870/vector-borne-and-zoonotic-diseases-of-dogs-in-north-west-new-south-wales-and-the-northern-territory-australia
#1
Amanda J Shapiro, Graeme Brown, Jacqueline M Norris, Katrina L Bosward, Debbie J Marriot, Nandhakumar Balakrishnan, Edward B Breitschwerdt, Richard Malik
BACKGROUND: Vector-borne diseases of dogs in Australian Aboriginal communities are relatively unexplored. These dogs represent a unique group with variable ecto- and endo-parasitic burdens, nutritional stresses and a general lack of veterinary intervention. We investigated haemoprotozoal and bacterial pathogen prevalences in relation to erythrocyte and platelet numbers in dogs from North-West New South Wales (N-W NSW) and the Northern Territory (NT; Central Australia). METHODS: Real-time PCR (qPCR) amplification of Anaplasma platys, Babesia vogeli, Mycoplasma haemocanis, Candidatus Mycoplasma haematoparvum and Bartonella spp...
August 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28807858/host-specificity-pathogen-exposure-and-superinfections-impact-the-distribution-of-anaplasma-phagocytophilum-genotypes-in-ticks-roe-deer-and-livestock-in-a-fragmented-agricultural-landscape
#2
Amélie Chastagner, Angélique Pion, Hélène Verheyden, Bruno Lourtet, Bruno Cargnelutti, Denis Picot, Valérie Poux, Émilie Bard, Olivier Plantard, Karen D McCoy, Agnes Leblond, Gwenaël Vourc'h, Xavier Bailly
Anaplasma phagocytophilum is a bacterial pathogen mainly transmitted by Ixodes ricinus ticks in Europe. It infects wild mammals, livestock, and, occasionally, humans. Roe deer are considered to be the major reservoir, but the genotypes they carry differ from those that are found in livestock and humans. Here, we investigated whether roe deer were the main source of the A. phagocytophilum genotypes circulating in questing I. ricinus nymphs in a fragmented agricultural landscape in France. First, we assessed pathogen prevalence in 1837 I...
August 11, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28807290/exposure-to-vector-borne-pathogens-in-privately-owned-dogs-living-in-different-socioeconomic-settings-in-brazil
#3
Luciana Aguiar Figueredo, Kamila Gaudêncio da Silva Sales, Katrin Deuster, Matthias Pollmeier, Domenico Otranto, Filipe Dantas-Torres
This survey was conducted in four Brazilian cities, from three federative units (Pernambuco, Minas Gerais, and Federal District), representing different socioeconomic settings, to determine the presence of antibodies to or antigens and DNA of selected pathogens in privately owned dogs. From January to April 2015, blood and serum samples were collected and assayed using different tests. In particular, antibodies to Anaplasma spp., Borrelia burgdorferi sensu lato, and Ehrlichia spp., and antigens of Dirofilaria immitis were detected using a rapid enzyme-linked immunosorbent assay, whereas antibodies to Babesia spp...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28799685/ecological-factors-influencing-small-mammal-infection-by-anaplasma-phagocytophilum-and-borrelia-burgdorferi-s-l-in-agricultural-and-forest-landscapes
#4
Grégoire Perez, Suzanne Bastian, Amélie Chastagner, Albert Agoulon, Olivier Plantard, Gwenaël Vourc'h, Alain Butet
Small mammals are key components of numerous tick-borne disease systems, as hosts for immature ticks and pathogen reservoirs. To study the factors influencing tick-borne infection in small mammals, we trapped small mammals and collected questing ticks in spring and autumn in 2012 and 2013 at 24 sites in a 10x15 km rural landscapes (Brittany, France). Tissue samples were screened by real-time PCR for Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato. Of the two dominant small mammal species captured, bank voles (Myodes glareolus) had higher prevalence than wood mice (Apodemus sylvaticus) for both infections, presumably because of specific differences in immunological defenses...
August 11, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28797056/anaplasma-phagocytophilum-infection-modulates-expression-of-megakaryocyte-cell-cycle-genes-through-phosphatidylinositol-3-kinase-signaling
#5
Supreet Khanal, Hameeda Sultana, John D Catravas, Jason A Carlyon, Girish Neelakanta
Anaplasma phagocytophilum, the agent of human granulocytic anaplasmosis infects neutrophils and other cells from hematopoietic origin. Using human megakaryocytic cell line, MEG-01, we show that expression of cell cycle genes in these cells are altered upon A. phagocytophilum infection. Expression of several cell cycle genes in MEG-01 cells was significantly up regulated at early and then down regulated at later stages of A. phagocytophilum infection. Lactate dehydrogenase (LDH) assays revealed reduced cellular cytotoxicity in MEG-01 cells upon A...
2017: PloS One
https://www.readbyqxmd.com/read/28776227/seroprevalence-and-risk-factors-associated-with-ehrlichia-canis-anaplasma-spp-borrelia-burgdorferi-sensu-lato-and-d-immitis-in-hunting-dogs-from-southern-italy
#6
Diego Piantedosi, Benedetto Neola, Nicola D'Alessio, Francesca Di Prisco, Mario Santoro, Laura Pacifico, Giovanni Sgroi, Luigi Auletta, Jesse Buch, Ramaswamy Chandrashekar, Edward B Breitschwerdt, Vincenzo Veneziano
Canine vector-borne diseases (CVBDs) are caused by a range of pathogens transmitted to dogs by arthropods. The present study investigates Ehrlichia canis, Anaplasma spp., Borrelia burgdorferi sensu lato, and Dirofilaria immitis seroprevalences in hunting dogs from southern Italy. Dogs (no. 1335) were tested using a commercial in-clinic enzyme-linked immunosorbent assay kit. Odds ratios (ORs) were calculated by logistic regression analysis to identify risk factors. Overall, 138/1335 dogs (10.3%) were seroreactive to at least one CVBD pathogen...
August 4, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28764743/one-particular-anaplasma-phagocytophilum-ecotype-infects-cattle-in-the-camargue-france
#7
Thibaud Dugat, Agnès Leblond, Nicolas Keck, Anne-Claire Lagrée, Isabelle Desjardins, Aurélien Joulié, Sophie Pradier, Benoit Durand, Henri-Jean Boulouis, Nadia Haddad
BACKGROUND: Anaplasma phagocytophilum is a zoonotic tick-borne pathogen responsible for granulocytic anaplasmosis, a mild to a severe febrile disease that affects man and several animal species, including cows and horses. In Europe, I. ricinus is the only proven vector for this pathogen, but studies suggest that other tick genera and species could be involved in its transmission. Our objective was to assess the presence and genetic diversity of A. phagocytophilum in domestic animals and different tick species from the Camargue region, located in the south of France...
August 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28754151/identification-of-anaplasma-ovis-appendage-associated-protein-aaap-for-development-of-an-indirect-elisa-and-its-application
#8
Zhenguo Wang, Jifei Yang, Qingli Niu, Kelly A Brayton, Jianxun Luo, Guangyuan Liu, Hong Yin, Zhijie Liu
BACKGROUND: Ovine anaplasmosis is a tick-borne disease that is caused by Anaplasma ovis in sheep and goats. The pathogen is widely distributed in tropical and subtropical regions of the world. At present, diagnosis of the disease mainly depends on microscopy or nucleic acid based molecular tests, although a few serological tests have been applied for the detection of A. ovis infection. RESULTS: Here we describe the identification of an A. ovis protein that is homologous to the A...
July 28, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28750866/two-novel-ehrlichia-strains-detected-in-amblyomma-tigrinum-ticks-associated-to-dogs-in-peri-urban-areas-of-argentina
#9
Gabriel L Cicuttin, M Nazarena De Salvo, Santiago Nava
The aim of this work was to describe two novel strains of Ehrlichia associated to Amblyomma tigrinum from Argentina. Molecular detection of agents belonging to the family Anaplasmataceae was performed targeting three different loci: 16S rRNA gene, dsb gene and a fragment of groESL heat shock operon. The results have shown that two different strains of Ehrlichia sp. associated to A. tigrinum are circulating in peri-urban areas of Argentina. The Ehrlichia strain detected in ticks from San Luis Province, named as Ehrlichia sp...
August 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28750863/microscopic-and-molecular-identification-of-hemotropic-mycoplasmas-in-south-american-coatis-nasua-nasua
#10
Michelle P Cubilla, Leonilda C Santos, Wanderlei de Moraes, Zalmir S Cubas, Christian M Leutenegger, Marko Estrada, LeAnn L Lindsay, Edvaldo S Trindade, Célia Regina C Franco, Rafael F C Vieira, Alexander W Biondo, Jane E Sykes
Hemoplasmas were detected in two apparently healthy captive South American coatis (Nasua nasua) from southern Brazil during an investigation for vector-borne pathogens. Blood was subjected to packed cell volume (PCV) determination, a commercial real-time PCR panel for the detection of Anaplasma spp., Babesia spp., Bartonella spp., Hepatozoon spp., Leishmania spp., Mycoplasma haemofelis, 'Candidatus Mycoplasma turicensis', 'Candidatus Mycoplasma haemominutum', Neorickettsia risticii, Rickettsia rickettsii and Leptospira spp...
August 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28749289/clinical-disease-associated-with-anaplasma-phagocytophilum-infection-in-captive-przewalski-s-horses-equus-ferus-przewalskii
#11
Richard R Sim, Priscilla H Joyner, Luis R Padilla, Paul Anikis, Copper Aitken-Palmer
Anaplasma phagocytophilum is a tick-borne pathogen of domestic horses and the causative agent of equine granulocytic anaplasmosis. This case series describes three confirmed cases of clinical anaplasmosis, and a fourth case of presumptive anaplasmosis in Przewalski's horses ( Equus ferus przewalskii) housed at the Smithsonian Conservation Biology Institute from 2008 to 2014. Clinical signs varied among individuals with affected horses exhibiting lethargy, weakness, pyrexia, hypophagia, reluctance to move, or ataxia...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749278/survey-of-anaplasma-phagocytophilum-antibodies-in-captive-przewalski-s-horses-equus-ferus-przewalskii
#12
Richard R Sim, Luis R Padilla, Priscilla H Joyner, Paul Anikis, Copper Aitken-Palmer
Anaplasma phagocytophilum (formerly Ehrlichia equi ) is a tickborne pathogen of domestic horses and the causative agent of equine granulocytic anaplasmosis. After the occurrence of clinical anaplasmosis in a Przewalski's horse ( Equus ferus przewalskii) housed at the Smithsonian Conservation Biology Institute in 2008, opportunistic serosurveillance of the herd was initiated. From 2008 to 2014, 57 serum samples were collected from 27 individuals (10 males; 17 females). Using indirect immunofluorescent antibody assays for anti- Anaplasma phagocytophilum antibodies, it was determined that prevalence was 53%...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28745029/adam10-and-notch1-on-murine-dendritic-cells-control-the-development-of-type-2-immunity-and-ige-production
#13
Sheela R Damle, Rebecca K Martin, Chelsea L Cockburn, Joseph C Lownik, Jason A Carlyon, Allen D Smith, Daniel H Conrad
BACKGROUND: Allergy and allergic asthma are significant health burdens in developed countries and are increasing in prevalence. Dendritic cells (DCs) initiate immune responses to common aeroallergens and ADAM10 has been demonstrated to be important for the development of adaptive responses. This study's objective was to understand the role of ADAM10 on DCs in the development of allergic and anaphylactic responses. METHODS: In this study we used mouse models of allergic airway inflammation (house dust mice and Alternaria alternata) and OVA-induced models of active anaphylaxis to determine the DC-specific function of ADAM10 and Notch signaling...
July 26, 2017: Allergy
https://www.readbyqxmd.com/read/28739301/a-new-pcr-assay-for-the-detection-and-differentiation-of-babesia-canis-and-babesia-vogeli
#14
Giada Annoscia, Maria Stefania Latrofa, Cinzia Cantacessi, Emanuela Olivieri, Maria Teresa Manfredi, Filipe Dantas-Torres, Domenico Otranto
Babesia spp. are globally distributed tick-borne protozoan parasites that infect the red blood cells of a wide range of vertebrate hosts, including humans. Diagnosis of babesiosis is often impeded by the transient presence of the parasites in peripheral blood, as well as by their pleomorphic nature. Given the reports of an expanding and, in some cases, sympatric geographical distribution of Babesia canis and Babesia vogeli in dogs and associated vectors, in Europe, the development of time-efficient and cost-effective diagnostic tools to detect and differentiate these two species is warranted...
July 8, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28738085/a-bayesian-spatio-temporal-model-for-forecasting-anaplasma-species-seroprevalence-in-domestic-dogs-within-the-contiguous-united-states
#15
Yan Liu, Stella C Watson, Jenna R Gettings, Robert B Lund, Shila K Nordone, Michael J Yabsley, Christopher S McMahan
This paper forecasts the 2016 canine Anaplasma spp. seroprevalence in the United States from eight climate, geographic and societal factors. The forecast's construction and an assessment of its performance are described. The forecast is based on a spatial-temporal conditional autoregressive model fitted to over 11 million Anaplasma spp. seroprevalence test results for dogs conducted in the 48 contiguous United States during 2011-2015. The forecast uses county-level data on eight predictive factors, including annual temperature, precipitation, relative humidity, county elevation, forestation coverage, surface water coverage, population density and median household income...
2017: PloS One
https://www.readbyqxmd.com/read/28725639/anaplasma-phagocytophilum-msp4-and-hsp70-proteins-are-involved-in-interactions-with-host-cells-during-pathogen-infection
#16
Marinela Contreras, Pilar Alberdi, Lourdes Mateos-Hernández, Isabel G Fernández de Mera, Ana L García-Pérez, Marie Vancová, Margarita Villar, Nieves Ayllón, Alejandro Cabezas-Cruz, James J Valdés, Snorre Stuen, Christian Gortazar, José de la Fuente
Anaplasma phagocytophilum transmembrane and surface proteins play a role during infection and multiplication in host neutrophils and tick vector cells. Recently, A. phagocytophilum Major surface protein 4 (MSP4) and Heat shock protein 70 (HSP70) were shown to be localized on the bacterial membrane, with a possible role during pathogen infection in ticks. In this study, we hypothesized that A. phagocytophilum MSP4 and HSP70 have similar functions in tick-pathogen and host-pathogen interactions. To address this hypothesis, herein we characterized the role of these bacterial proteins in interaction and infection of vertebrate host cells...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28722568/epidemiology-of-spotted-fever-group-rickettsioses-and-acute-undifferentiated-febrile-illness-in-villeta-colombia
#17
Álvaro A Faccini-Martínez, Alejandro Ramírez-Hernández, Christian Barreto, Elkin Forero-Becerra, Diego Millán, Elkin Valbuena, Andrea C Sánchez-Alfonso, Wilson O Imbacuán-Pantoja, Jesús A Cortés-Vecino, Luis J Polo-Terán, Néstor Yaya-Lancheros, Jorge Jácome, Ana M Palomar, Sonia Santibáñez, Aránzazu Portillo, José A Oteo, Marylin Hidalgo
Etiology of acute undifferentiated febrile syndrome (AUFS) is often unknown, leading to inaccurate diagnosis and treatment. Villeta town has been identified as an endemic area for spotted fever group (SFG) rickettsioses but little is known about possible amplifier hosts and other Rickettsia species different from Rickettsia rickettsii. Besides, few studies have approached other AUFS etiologies in the region. We investigated the role of dengue, leptospirosis, rickettsioses, human anaplasmosis, and Q fever as possible causes of AUFS in patients from Villeta...
June 19, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28697801/interferon-%C3%AE-dependent-control-of-anaplasma-phagocytophilum-by-murine-neutrophil-granulocytes
#18
Kathrin Gussmann, Susanne Kirschnek, Friederike D von Loewenich
BACKGROUND: Anaplasma phagocytophilum is a Gram-negative obligate intracellular bacterium that is transmitted by ticks of the Ixodes ricinus complex. It replicates in neutrophils and elicits febrile disease in humans and animals. Because of its striking tropism for neutrophils, A. phagocytophilum has been used as a model organism to study the immune response against obligate intracellular pathogens. In mice, the control of A. phagocytophilum in the early phase of infection is dependent on natural killer cell-derived interferon-γ (IFN-γ)...
July 12, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28690147/novel-anaplasma-and-ehrlichia-organisms-infecting-the-wildlife-of-two-regions-of-the-brazilian-amazon
#19
Herbert S Soares, Arlei Marcili, Amália R M Barbieri, Antonio H H Minervino, Antonio F Malheiros, Solange M Gennari, Marcelo B Labruna
During 2009-2012, wild animals were sampled in the Amazon biome of Brazil. Animal tissues and blood were tested by polymerase chain reaction (PCR) assays targeting DNA of the bacterial family Anaplasmataceae (genera Anaplasma, Ehrlichia, Wolbachia) and the genus Borrelia. Overall, 181 wild animals comprising 36 different species (2 reptiles, 5 birds, and 29 mammals) were sampled. All birds and reptiles were negative by all PCR assays, as well as all mammals for the Borrelia PCR assay. Anaplasmataceae agents were searched by PCR assays targeting two different genes, the ribosomal 16S rRNA gene and the protein-coding dsb gene...
July 6, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28682765/a-pcr-survey-of-vector-borne-pathogens-in-different-dog-populations-from-turkey
#20
Huanping Guo, Ferda Sevinc, Onur Ceylan, Mutlu Sevinc, Ege Ince, Yang Gao, Paul Franck Adjou Moumouni, Mingming Liu, Artemis Efstratiou, Guanbo Wang, Shinuo Cao, Mo Zhou, Charoonluk Jirapattharasate, Aaron Edmond Ringo, Weiqing Zheng, Xuenan Xuan
In the present study, a total of 192 blood samples were collected from pet dogs, kennel dogs and shepherd dogs in Konya district, Turkey, and tested by specific PCR for the presence of vector-borne pathogens. Several pathogens were identified, most of which can cause substantial morbidity in dogs. PCR results revealed that 54 (28.1%) dogs were infected with one or more pathogens. Positive results were obtained for Babesia spp. in 4 dogs (2.1%), Hepatozoon spp. in 8 dogs (4.2%) and Mycoplasma spp. in 46 dogs (24%)...
September 26, 2017: Acta Parasitologica
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