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https://www.readbyqxmd.com/read/28919803/empirical-validation-of-the-horowitz-multiple-systemic-infectious-disease-syndrome-questionnaire-for-suspected-lyme-disease
#1
Maryalice Citera, Phyllis R Freeman, Richard I Horowitz
PURPOSE: Lyme disease is spreading worldwide, with multiple Borrelia species causing a broad range of clinical symptoms that mimic other illnesses. A validated Lyme disease screening questionnaire would be clinically useful for both providers and patients. Three studies evaluated such a screening tool, namely the Horowitz Multiple Systemic Infectious Disease Syndrome (MSIDS) Questionnaire. The purpose was to see if the questionnaire could accurately distinguish between Lyme patients and healthy individuals...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28918538/genetic-manipulation-of-borrelia-spp
#2
Dan Drecktrah, D Scott Samuels
The spirochetes Borrelia (Borreliella) burgdorferi and Borrelia hermsii, the etiologic agents of Lyme disease and relapsing fever, respectively, cycle in nature between an arthropod vector and a vertebrate host. They have extraordinarily unusual genomes that are highly segmented and predominantly linear. The genetic analyses of Lyme disease spirochetes have become increasingly more sophisticated, while the age of genetic investigation in the relapsing fever spirochetes is just dawning. Molecular tools available for B...
September 17, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28918069/studies-that-report-unexpected-positive-blood-cultures-for-lyme-borrelia-are-they-valid
#3
REVIEW
Gary P Wormser, Eugene D Shapiro, Franc Strle
Positive blood cultures for Lyme borrelia have been well documented in untreated patients with early Lyme disease. In this report we review the validity of three studies that reported the recovery of Borrelia burgdorferi sensu lato from the blood of a high proportion of patients for whom no evidence was presented, and no claim was made, that the patients had untreated early Lyme disease. In two of the studies the patients had been treated extensively with antibiotics for Lyme disease before the cultures were obtained...
July 29, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28917304/prevalence-of-ticks-and-tick-borne-pathogens-babesia-and-borrelia-species-in-ticks-infesting-cats-of-great-britain
#4
Saran Davies, Swaid Abdullah, Chris Helps, Séverine Tasker, Hannah Newbury, Richard Wall
In a study of tick and tick-borne pathogen prevalence, between May and October 2016, 278 veterinary practices in Great Britain examined 1855 cats. Six-hundred and one cats were found to have attached ticks. The most frequently recorded tick species was Ixodes ricinus (57.1%), followed by Ixodes hexagonus (41.4%) and Ixodes trianguliceps (1.5%). Male cats, 4-6 years of age living in rural areas were most likely to be carrying a tick; hair length and tick treatment history had no significant association with attachment...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28912318/chromosome-and-large-linear-plasmid-sequences-of-a-borrelia-miyamotoi-strain-isolated-from-ixodes-pacificus-ticks-from-california
#5
Luke C Kingry, Adam Replogle, Marc Dolan, Christopher Sexton, Kerry A Padgett, Martin E Schriefer
Borrelia miyamotoi, a relapsing fever group spirochete, is an emerging tick-borne pathogen. It has been identified in ixodid ticks across the Northern Hemisphere, including the West Coast of the United States. We describe the chromosome and large linear plasmid sequence of a B. miyamotoi isolate cultured from a California field-collected Ixodes pacificus tick.
September 14, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28911844/serologic-responses-to-peptides-of-anaplasma-phagocytophilum-and-borrelia-burgdorferi-in-dogs-infested-with-wild-caught-ixodes-scapularis
#6
R Chandrashekar, M J Beall, B Thatcher, J M Saucier, P Tyrrell, M R Lappin
Anaplasma phagocytophilum and Borrelia burgdorferi are both transmitted by Ixodes spp. and are associated with clinical illness in some infected dogs. This study evaluated canine antibody responses to the A. phagocytophilum p44 peptides APH-1 and APH-4 as well as the B. burgdorferi C6 peptide before and after doxycycline treatment. A total of eight dogs were infested with wild-caught I. scapularis for 1 week. Blood was collected prior to tick attachment and from Days 3-77 to 218-302 with doxycycline treatment beginning on Day 218...
August 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28911326/borrelia-infection-and-risk-of-celiac-disease
#7
Armin Alaedini, Benjamin Lebwohl, Gary P Wormser, Peter H Green, Jonas F Ludvigsson
BACKGROUND: Environmental factors, including infectious agents, are speculated to play a role in the rising prevalence and the geographic distribution of celiac disease, an autoimmune disorder. In the USA and Sweden where the regional variation in the frequency of celiac disease has been studied, a similarity with the geographic distribution of Lyme disease, an emerging multisystemic infection caused by Borrelia burgdorferi spirochetes, has been found, thus raising the possibility of a link...
September 15, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28905982/vector-borne-diseases-in-cats-in-germany
#8
Michèle Bergmann, Katrin Hartmann
Vector-borne diseases (VBDs) are caused by a wide range of pathogens, which are transmitted by a variety of vectors, such as ticks and fleas. As a result of climate changes, more vector-borne diseases are becoming endemic in Germany, not only in dogs, but also in cats. For some of the pathogens prevalence data still need to be investigated in Germany. However, natural infections with Bartonella, Anaplasma, haemotropic Mycoplasma and Borrelia species have already been described in German cats. Clinical relevance of these pathogens is not fully understood, and it is still unknown, why most infected cats stay asymptomatic and which predisposing factors contribute to the development of clinical signs in cats...
September 13, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28905981/-heterogeneity-of-canine-immune-responses-to-borrelia-burgdorferi-in-a-line-immunoassay-comprising-recombinant-vlse-and-c6-peptide
#9
Doris Breu, Elisabeth Müller
OBJECTIVE: The study aimed to investigate the distribution of specific immune responses (IgG) to Borrelia burgdorferi using a line immunoassay with recombinant VlsE (variable major protein-like sequence, expressed) protein and synthetic C peptide among other antigens. We compared the immune responses to VlsE protein and C6 peptide, because both antigens have been considered specific for a Borrelia infection. MATERIALS AND METHODS: A total of 1355 blood samples from dogs suspected of Borrelia infection were analysed...
September 13, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28902847/first-insights-in-the-variability-of-borrelia-recurrentis-genomes
#10
Durdica Marosevic, Gabriele Margos, Reinhard Wallich, Andreas Wieser, Andreas Sing, Volker Fingerle
BACKGROUND: Borrelia recurrentis is the causative agent of louse-borne relapsing fever, endemic to the Horn of Africa. New attention was raised in Europe, with the highest number of cases (n = 45) reported among migrants in 2015 in Germany and sporadically from other European countries. So far only one genome was sequenced, hindering the development of specific molecular diagnostic and typing tools. Here we report on modified culture conditions for B. recurrentis and the intraspecies genome variability of six isolates isolated and cultured in different years in order to explore the possibility to identify new targets for typing and examine the molecular epidemiology of the pathogen...
September 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28898274/periplasmic-flagella-in-borrelia-burgdoferi-function-to-maintain-cellular-integrity-upon-external-stress
#11
Bharath Kumar, Kelly Miller, Nyles W Charon, Justin Legleiter
Tapping mode atomic force microscopy (AFM) in solution was used to analyze the role of the internally located periplasmic flagella (PFs) of the Lyme disease spirochete Borrelia burgdorferi in withstanding externally applied cellular stresses. By systematically imaging immobilized spirochetes with increasing tapping forces, we found that mutants that lack PFs are more readily compressed and damaged by the imaging process compared to wild-type cells. This finding suggest that the PFs, aside from being essential for motility and involved in cell shape, play a cytoskeletal role in dissipating energy and maintaining cellular integrity in the presence of external stress...
2017: PloS One
https://www.readbyqxmd.com/read/28887186/to-test-or-not-to-test-laboratory-support-for-the-diagnosis-of-lyme-borreliosis
#12
REVIEW
Ram B Dessau, Alje P van Dam, Volker Fingerle, Jeremy Gray, Joppe Hovius, Klaus-Peter Hunfeld, Benoit Jaulhac, Olaf Kahl, Wolfgang Kristoferitsch, Per-Eric Lindgren, Mateusz Markowicz, Sally Mavin, Katharina Ornstein, Tobias Rupprecht, Gerold Stanek, Franc Strle
BACKGROUND: Lyme borreliosis (LB) is a tick-borne infection caused by Borrelia burgdorferi sensu lato. The most frequent clinical manifestations are erythema migrans and Lyme neuroborreliosis. Currently, a large volume of diagnostic testing for Lyme borreliosis is reported, whereas the incidence of clinically relevant disease manifestations is low. This indicates overuse of diagnostic testing for LB with implications for patient care and cost effective health management. AIM: The recommendations provided in this review are intended to support both the clinical diagnosis and initiatives for a more rational use of laboratory testing in patients with clinically suspected Lyme borreliosis...
September 5, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28884668/borrelia-lanei-sp-nov-extends-the-diversity-of-borrelia-species-in-california
#13
Gabriele Margos, Natalia Fedorova, Joyce E Kleinjan, Christine Hartberger, Tom G Schwan, Andreas Sing, Volker Fingerle
The diversity of Borrelia species discovered in California appears to be particularly high. A divergent group of Borrelia strains collected from Ixodes ticks in California was described by Postic and co-workers and designated 'genomospecies 2' (Postic D, Garnier M, Baranton G. Int J Med Microbiol 2007;297:263-271; Postic D, Ras NM, Lane RS, Hendson M, Baranton G. J Clin Microbiol 1998;36:3497-3504). We performed multilocus sequence analysis (MLSA) using eight housekeeping loci (clpA, clpX, nifS, pepX, pyrG, recG, rplB and uvrA) on 12 strains of this Borreliagenospecies to confirm that these strains form a distinct group within the Borreliaburgdorferi s...
September 8, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28882852/human-seroprevalence-of-borrelia-miyamotoi-in-manitoba-canada-in-2011-2014-a-cross-sectional-study
#14
Kamran Kadkhoda, Cecilia Dumouchel, Janna Brancato, Ainsley Gretchen, Peter J Krause
BACKGROUND: Hard tick-borne relapsing fever caused by Borrelia miyamotoi has been reported in Russia, the Netherlands, Germany, Japan and the northeastern and upper midwestern United States. We sought to investigate the presence of B. miyamotoi infection in humans in Manitoba, Canada. METHODS: Two hundred fifty sera collected from residents of Manitoba with suspected Lyme disease between 2011 and 2014 were tested for Borrelia burgdorferi antibody using a C6 peptide enzyme-linked immunosorbent assay (ELISA) followed by Western blot...
September 6, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28879619/borrelia-miyamotoi-other-vector-borne-agents-in-cat-blood-and-ticks-in-eastern-maryland
#15
Avery B Shannon, Renee Rucinsky, Holly D Gaff, R Jory Brinkerhoff
We collected blood and tick samples in eastern Maryland to quantify vector-borne pathogen exposure and infection in healthy cats and to assess occupational disease risk to veterinary professionals and others who regularly interact with household pets. Thirty-six percent of healthy cats parasitized by ticks at time of examination (9/25) were exposed to, and 14% of bloods (7/49) tested PCR-positive for, at least one vector-borne pathogen including several bloods and ticks with Borrelia miyamotoi, a recently recognized tick-borne zoonotic bacterium...
September 6, 2017: EcoHealth
https://www.readbyqxmd.com/read/28878005/citrate-anticoagulant-improves-the-sensitivity-of-borreliella-borrelia-burgdorferi-plasma-culture
#16
Adriana R Marques, Xiuli Yang, Alexis A Smith, Xuran Zhuang, Siu-Ping Turk, Carla D Williams, Melissa A Law, Alan G Barbour, Utpal Pal
The ability of cultivating Borreliella (Borrelia) burgdorferi is a cornerstone of Lyme disease research.….
September 6, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28875270/molecular-evidence-of-tick-borne-pathogens-in-hyalomma-anatolicum-ticks-infesting-cattle-in-xinjiang-uygur-autonomous-region-northwestern-china
#17
Peifa Yu, Zhijie Liu, Qingli Niu, Jifei Yang, Mirza Omar Abdallah, Ze Chen, Guangyuan Liu, Jianxun Luo, Hong Yin
Although tick-borne pathogens have been widely reported in ticks in China, there is little information available on the prevalence of information in Hyalomma ticks from cattle. This study aims to determine the occurrence of pathogens in Hyalomma anatolicum collected from cattle in Xinjiang Uygur Autonomous Region, China, by PCR, sequencing and phylogenetic analysis. Borrelia burgdorferi s.s., Rickettsia massiliae and Anaplasma bovis were identified, whereas DNA of Ehrlichia species and an Anaplasma platys-like pathogen were also detected...
September 5, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28874457/correction-for-chenail-et-al-borrelia-burgdorferi-cp32-bpab-modulates-expression-of-the-prophage-nucp-nuclease-and-ssbp-single-stranded-dna-binding-protein
#18
Alicia M Chenail, Brandon L Jutras, Claire A Adams, Logan H Burns, Amy Bowman, Ashutosh Verma, Brian Stevenson
No abstract text is available yet for this article.
October 1, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28874456/correction-for-jutras-et-al-changes-in-bacterial-growth-rate-govern-expression-of-the-borrelia-burgdorferi-ospc-and-erp-infection-associated-surface-proteins
#19
Brandon L Jutras, Alicia M Chenail, Brian Stevenson
No abstract text is available yet for this article.
October 1, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28874019/detection-in-malaysia-of-a-borrelia-sp-from-haemaphysalis-hystricis-ixodida-ixodidae
#20
J J Khoo, F S Lim, K K Tan, F S Chen, W H Phoon, C S Khor, B L Pike, L Y Chang, S AbuBakar
Spirochetes from the Borrelia genus are known to cause diseases in humans, namely Lyme disease and relapsing fever. These organisms are commonly transmitted to humans by arthropod vectors including ticks, mite, and lice. Here, we report the molecular detection of a Borrelia sp. from a Haemaphysalis hystricis Supino tick collected from wildlife in an Orang Asli settlement in Selangor, Malaysia. Phylogenetic analyses of partial 16s rRNA and flaB gene sequences revealed that the Borrelia sp. is closely related to the relapsing fever group borreliae, Borrelia lonestari, Borrelia miyamotoi, and Borrelia theileri, as well as a number of uncharacterized Borrelia sp...
September 1, 2017: Journal of Medical Entomology
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