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https://www.readbyqxmd.com/read/29782295/diagnostic-and-treatment-strategies-of-dermatologists-for-treating-morphea-in-hungary
#1
Gábor Bali, Bernadett Hidvégi
Localized scleroderma is an uncommon disease, only infrequently encountered by dermatologists in private practices or even in larger academic centers. Because of its rarity, current treatment guidelines are mostly based on low-level clinical evidence and expert opinions. The aim of this study was to evaluate treatment strategies to treat localized scleroderma. A questionnaire was developed and sent to dermatologists in Hungary. 101 returned questionnaires were eligible for evaluation. 87.12% of clinicians employed local steroids...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29776392/molecular-identification-of-tick-borne-pathogens-in-asymptomatic-individuals-with-human-immunodeficiency-virus-type-1-hiv-1-infection-a-retrospective-study
#2
Renata Welc-Falęciak, Justyna D Kowalska, Małgorzata Bednarska, Magdalena Szatan, Agnieszka Pawełczyk
BACKGROUND: The studies on the occurrence and diversity of tick-borne infections in HIV-infected individuals have been few, and the subject has been relatively neglected when compared with other common infections associated with HIV. In HIV-positive patients in whom a serological diagnostics is complicated due to reduced positive predictive value, a method where the microorganism is detected directly is of great value. Therefore, we performed a molecular study to ascertain the prevalence and incidence of tick-borne infections in HIV-infected persons in Poland, an endemic area for Ixodes ricinus ticks...
May 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29776377/shifts-in-borrelia-burgdorferi-s-l-geno-species-infections-in-ixodes-ricinus-over-a-10-year-surveillance-period-in-the-city-of-hanover-germany-and-borrelia-miyamotoi-specific-reverse-line-blot-detection
#3
Katrin Blazejak, Marie-Kristin Raulf, Elisabeth Janecek, Daniela Jordan, Volker Fingerle, Christina Strube
BACKGROUND: Lyme borreliosis caused by spirochetes of the Borrelia burgdorferi (sensu lato) complex is still the most common tick-borne disease in Europe, posing a considerable threat to public health. The predominant vector in Europe is the widespread hard tick Ixodes ricinus, which also transmits the relapsing fever spirochete B. miyamotoi as well as pathogenic Rickettsiales (Anaplasma phagocytophilum, Rickettsia spp.). To assess the public health risk, a long-term monitoring of tick infection rates with the named pathogens is indispensable...
May 18, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29774138/clinical-evaluation-of-morgellons-disease-in-a-cohort-of-north-american-patients
#4
Melissa C Fesler, Marianne J Middelveen, Raphael B Stricker
Morgellons disease (MD) is a dermatological condition characterized by aberrant production of keratin and collagen fibers in skin. Although infection with Borrelia burgdorferi , the causative agent of Lyme disease (LD), has been associated with MD, relatively few studies have hitherto provided epidemiological evidence regarding this association. A cohort of 1000 seropositive North American LD patients was evaluated for the presence of MD. Patients were diagnosed with MD based on detection of microscopic fibers in skin lesions or under unbroken skin...
April 23, 2018: Dermatology Reports
https://www.readbyqxmd.com/read/29763485/what-s-eating-you-ixodes-tick-and-related-diseases-part-2-diagnosis-and-treatment-of-regional-tick-borne-diseases
#5
Kelsey D Wilson, Dirk M Elston
The Ixodes tick is an important arthropod vector in the transmission of human disease. Although Lyme disease is the most prevalent zoonosis transmitted by Ixodes ticks, other less common diseases may be encountered, including human granulocytic anaplasmosis, babesiosis, Powassan virus infection, tick-borne encephalitis, Borrelia miyamotoi disease, and tick paralysis. In part 2 of this review, disease presentation, diagnosis, and treatment of these less commonly encountered tick-borne diseases are discussed.
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29762516/seasonal-patterns-in-the-prevalence-and-diversity-of-tick-borne-borrelia-burgdorferi-sensu-lato-anaplasma-phagocytophilum-and-rickettsia-spp-in-an-urban-temperate-forest-in-south-western-slovakia
#6
Michal Chvostáč, Eva Špitalská, Radovan Václav, Tatiana Vaculová, Lenka Minichová, Markéta Derdáková
In Europe, Ixodes ricinus is the most important vector of tick-borne zoonotic bacteria. It transmits spirochaetes from the Borrelia burgdorferi sensu lato complex, Anaplasma phagocytophilum and Rickettsia spp. Although spatial differences in the prevalence of tick-borne pathogens have been intensively studied, seasonal (within-year) fluctuations in the prevalence of these pathogens within sites are often overlooked. We analyzed the occurrence and seasonal dynamics of Ixodes ricinus in an urban forest in Bratislava, Slovakia...
May 15, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29754986/the-microbiome-of-haemaphysalis-lemuris-acari-ixodidae-a-possible-vector-of-pathogens-of-endangered-lemur-species-in-madagascar
#7
Paula Lado, Barbara Qurollo, Cathy Williams, Randall Junge, Hans Klompen
Lemurs are primate species that are endemic to Madagascar. At present, about 90% of lemur species are endangered, and 5 species are among the 25 most endangered primates worldwide. Health status is a major factor impacting the viability of wild populations of many endangered species including lemurs. Given this context, we analyzed the microbiome of 24 specimens of Haemaphysalis lemuris, the most common tick parasitizing lemurs in their native habitats. Ticks were collected from 6 lemur species and microbiomes analyzed using next-generation sequencing...
May 2, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29749010/borrelia-burgdorferi-surface-located-lmp1-protein-processed-into-region-specific-polypeptides-that-are-critical-for-microbial-persistence
#8
Xuran Zhuang, Xiuli Yang, Amanda S Altieri, Daniel C Nelson, Utpal Pal
One of the Borrelia burgdorferi virulence determinants, annotated as Lmp1, is a surface-exposed, conserved and potential multi-domain protein involved in various functions in spirochete infectivity. Lmp1 contributes to host-pathogen interactions and evasion of host adaptive immunity by spirochetes. Here we show that in diverse B. burgdorferi species, Lmp1 exists as distinct, region-specific and lower molecular mass polypeptides encompassing one or more domains, including independent N-terminal and middle regions and a combined middle and C-terminal region...
May 10, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29746581/human-neuroglial-cells-internalize-borrelia-burgdorferi-by-coiling-phagocytosis-mediated-by-daam1
#9
Shanna K Williams, Zachary P Weiner, Robert D Gilmore
Borrelia burgdorferi, the agent of Lyme borreliosis, can elude hosts' innate and adaptive immunity as part of the course of infection. The ability of B. burgdorferi to invade or be internalized by host cells in vitro has been proposed as a mechanism for the pathogen to evade immune responses or antimicrobials. We have previously shown that B. burgdorferi can be internalized by human neuroglial cells. In this study we demonstrate that these cells take up B. burgdorferi via coiling phagocytosis mediated by the formin, Daam1, a process similarly described for human macrophages...
2018: PloS One
https://www.readbyqxmd.com/read/29746483/efficient-detection-of-symptomatic-and-asymptomatic-patient-samples-for-babesia-microti-and-borrelia-burgdorferi-infection-by-multiplex-qpcr
#10
Shekerah Primus, Lavoisier Akoolo, Samantha Schlachter, Kristine Gedroic, Albert D Rojtman, Nikhat Parveen
BACKGROUND: Tick-borne infections have been increasing steadily over the years, with co-infections with Borrelia burgdorferi and Babesia microti/divergens emerging as a serious health problem. B. burgdorferi is a spirochetal bacterium that causes Lyme disease while protozoan pathogens belonging to Babesia species are responsible for babesiosis. Currently used serological tests do not always detect acute Lyme disease or babesiosis, and fail to differentiate cured patients from those who get re-infected...
2018: PloS One
https://www.readbyqxmd.com/read/29738078/tick-borne-disease-risk-in-a-forest-food-web
#11
Richard S Ostfeld, Taal Levi, Felicia Keesing, Kelly Oggenfuss, Charles D Canham
Changes to the community ecology of hosts for zoonotic pathogens, particularly rodents, are likely to influence the emergence and prevalence of zoonotic diseases worldwide. However, the complex interactions between abiotic factors, pathogens, vectors, hosts, and both food resources and predators of hosts are difficult to disentangle. Here we (1) use 19 years of data from six large field plots in southeastern New York to compare the effects of hypothesized drivers of interannual variation in Lyme disease risk, including the abundance of acorns, rodents, and deer, as well as a series of climate variables; and (2) employ landscape epidemiology to explore how variation in predator community structure and forest cover influences spatial variation in the infection prevalence of ticks for the Lyme disease bacterium, Borrelia burgdorferi, and two other important tick-borne pathogens, Anaplasma phagocytophilum and Babesia microti...
May 8, 2018: Ecology
https://www.readbyqxmd.com/read/29728336/evaluation-of-the-protective-efficacy-of-ornithodoros-moubata-midgut-membrane-antigens-selected-using-omics-and-in-silico-prediction-algorithms
#12
Prosper Obolo-Mvoulouga, Ana Oleaga, Raúl Manzano-Román, Ricardo Pérez-Sánchez
The African argasid tick Ornithodoros moubata transmits two important pathogens, the African swine fever virus and the spirochete Borrelia duttoni, the cause of human relapsing fever. To date, only conventional control measures such as widespread application of acaricides, strict control measures, and animal movement restrictions have been implemented to confine these diseases. Vaccines against tick infestations have the potential to be among the most efficacious interventions for the management of these diseases...
April 30, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29723263/borrelia-burgdorferi-adhere-to-blood-vessels-in-the-dura-mater-and-are-associated-with-increased-meningeal-t-cells-during-murine-disseminated-borreliosis
#13
Ali Divan, Timothy Casselli, S Anand Narayanan, Sanjib Mukherjee, David C Zawieja, John A Watt, Catherine A Brissette, M Karen Newell-Rogers
Borrelia burgdorferi, the causative agent of Lyme disease, is a vector-borne bacterial infection that is transmitted through the bite of an infected tick. If not treated with antibiotics during the early stages of infection, disseminated infection can spread to the central nervous system (CNS). In non-human primates (NHPs) it has been demonstrated that the leptomeninges are among the tissues colonized by B. burgdorferi spirochetes. Although the NHP model parallels aspects of human borreliosis, a small rodent model would be ideal to study the trafficking of spirochetes and immune cells into the CNS...
2018: PloS One
https://www.readbyqxmd.com/read/29721281/effects-of-a-zoonotic-pathogen-borrelia-burgdorferi-on-the-behavior-of-a-key-reservoir-host
#14
Richard S Ostfeld, Dustin Brisson, Kelly Oggenfuss, Jill Devine, Michael Z Levy, Felicia Keesing
Most emerging infectious diseases of humans are transmitted to humans from other animals. The transmission of these "zoonotic" pathogens is affected by the abundance and behavior of their wildlife hosts. However, the effects of infection with zoonotic pathogens on behavior of wildlife hosts, particularly those that might propagate through ecological communities, are not well understood. Borrelia burgdorferi is a bacterium that causes Lyme disease, the most common vector-borne disease in the USA and Europe...
April 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29718024/what-s-eating-you-ixodes-tick-and-related-diseases-part-1-life-cycle-local-reactions-and-lyme-disease
#15
Kelsey D Wilson, Dirk M Elston
The Ixodes tick is an important arthropod vector in the transmission of human disease. This 3-part review highlights the biology of the Ixodes tick and manifestations of related diseases. Part 1 addresses the Ixodes tick biology and life cycle; local reactions; and Lyme disease, the most prevalent of associated diseases. Part 2 will address human granulocytic anaplasmosis, babesiosis, Powassan virus infection, Borrelia miyamotoi disease, tick-borne encephalitis, and tick paralysis. Part 3 will address coinfection with multiple pathogens as well as methods of tick-bite prevention and tick removal...
March 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29716838/low-probability-of-a-dilution-effect-for-lyme-borreliosis-in-belgian-forests
#16
Sanne C Ruyts, Dries Landuyt, Evy Ampoorter, Dieter Heylen, Steffen Ehrmann, Elena C Coipan, Erik Matthysen, Hein Sprong, Kris Verheyen
An increasing number of studies have investigated the consequences of biodiversity loss for the occurrence of vector-borne diseases such as Lyme borreliosis, the most common tick-borne disease in the northern hemisphere. As host species differ in their ability to transmit the Lyme borreliosis bacteria Borrelia burgdorferi s.l. to ticks, increased host diversity can decrease disease prevalence by increasing the proportion of dilution hosts, host species that transmit pathogens less efficiently. Previous research shows that Lyme borreliosis risk differs between forest types and suggests that a higher diversity of host species might dilute the contribution of small rodents to infect ticks with B...
April 22, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29716647/seroprevalence-of-borrelia-burgdorferi-in-belgian-forestry-workers-and-associated-risk-factors
#17
Mathilde De Keukeleire, Annie Robert, Victor Luyasu, Benoît Kabamba, Sophie O Vanwambeke
BACKGROUND: As forest is the preferred environment for ticks, forestry workers are exposed to tick bites and tick-borne diseases. We assessed the seroprevalence of anti-Borrelia burgdorferi (Bb) antibodies and investigated, using an integrated landscape approach, the individual and environmental factors associated with the seroprevalence of Bb in Belgian forestry workers, a high-risk group in Belgium. METHODS: A group of 310 Belgian forest workers was examined to assess the seroprevalence of anti-Borrelia IgG antibodies...
May 2, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29713635/detection-of-tick-borne-pathogens-in-lambs-undergoing-prophylactic-treatment-against-ticks-on-two-swedish-farms
#18
Giulio Grandi, Anna Aspán, Jenny Pihl, Katarina Gustafsson, Fredrik Engström, Tomas Jinnerot, Robert Söderlund, Jan Chirico
Tick-borne pathogens (TBPs), especially Anaplasma phagocytophilum , cause disease in grazing livestock. Tick prophylaxis is, therefore, a routine practice in sheep flocks in Sweden, especially in central, southern, and coastal areas of the country where ixodid ticks ( Ixodes ricinus and Haemaphysalis punctata ) are present. In the present study, the status of infection by A. phagocytophilum and other TBPs in lambs treated with tick prophylaxis has been assessed serologically and with polymerase chain reaction (PCR)...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29709572/an-overlapping-region-between-the-two-terminal-folding-units-of-the-outer-surface-protein-a-ospa-controls-its-folding-behavior
#19
Koki Makabe, Takashi Nakamura, Debanjan Dhar, Teikichi Ikura, Shohei Koide, Kunihiro Kuwajima
Although many naturally occurring proteins consist of multiple domains, most studies on protein folding to date deal with single-domain proteins or isolated domains of multi-domain proteins. Studies of multi-domain protein folding are required for further advancing our understanding of protein folding mechanisms. Borrelia outer surface protein A (OspA) is a β-rich two-domain protein, in which two globular domains are connected by a rigid and stable single-layer β-sheet. Thus, OspA is particularly suited as a model system for studying the interplays of domains in protein folding...
April 27, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29706237/-pathway-to-diagnosis-and-real-life-experience-of-patients-believing-they-are-affected-by-chronic-lyme-disease
#20
E Forestier, F Gonnet, A Revil-Signorat, A C Zipper
OBJECTIVES: Chronic Lyme disease is a subject of scientific and social controversy in both Europe and the United States. The aim of our study was to analyze the pathway to diagnosis of patients believing they were affected by the disease, and to describe their real-life experience. METHOD: A qualitative study was performed with 13 patients declaring themselves to be affected by chronic Lyme disease. Interviews were analyzed by 2 general medical practice interns, supervised by a general practitioner with a diploma in socio-anthropology and an infectious diseases specialist...
April 26, 2018: La Revue de Médecine Interne
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