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1,5-Anhydroglucitol

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https://www.readbyqxmd.com/read/28605542/alternative-measures-of-hyperglycemia-and-risk-of-alzheimer-s-disease-in-the-community-the-hisayama-study
#1
Naoko Mukai, Tomoyuki Ohara, Jun Hata, Yoichiro Hirakawa, Daigo Yoshida, Hiro Kishimoto, Masafumi Koga, Udai Nakamura, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya
Context and Objective: We investigated the associations of hemoglobin A1c (HbA1c), glycated albumin (GA), the GA/HbA1c ratio, and 1,5-anhydroglucitol (1,5-AG) with the development of Alzheimer's disease (AD) in community-dwelling Japanese subjects. Design and Participants: A total of 1,187 subjects aged ≥65 years without dementia were followed up for an average of 4.8 years. Results: During the follow-up, 116 subjects experienced AD. The age- and sex-adjusted incidence of AD increased significantly with higher quartiles of the GA/HbA1c ratio, and a similar tendency was seen for GA, while no such association was observed for HbA1c and 1,5-AG...
June 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28593615/a-single-dose-of-dapagliflozin-an-sglt-2-inhibitor-induces-higher-glycosuria-in-gck-and-hnf1a-mody-than-in-type-2-diabetes-mellitus
#2
J Hohendorff, M Szopa, J Skupien, M Kapusta, B Zapala, T Platek, S Mrozinska, T Parpan, W Glodzik, A Ludwig-Galezowska, B Kiec-Wilk, T Klupa, M T Malecki
AIMS: SGLT2 inhibitors are a new class of oral hypoglycemic agents used in type 2 diabetes (T2DM). Their effectiveness in maturity onset diabetes of the young (MODY) is unknown. We aimed to assess the response to a single dose of 10 mg dapagliflozin in patients with Hepatocyte Nuclear Factor 1 Alpha (HNF1A)-MODY, Glucokinase (GCK)-MODY, and type 2 diabetes. METHODS: We examined 14 HNF1A-MODY, 19 GCK-MODY, and 12 type 2 diabetes patients. All studied individuals received a single morning dose of 10 mg of dapagliflozin added to their current therapy of diabetes...
June 7, 2017: Endocrine
https://www.readbyqxmd.com/read/28588231/genome-wide-association-study-of-1-5-anhydroglucitol-identifies-novel-genetic-loci-linked-to-glucose-metabolism
#3
Man Li, Nisa M Maruthur, Stephanie J Loomis, Maik Pietzner, Kari E North, Hao Mei, Alanna C Morrison, Nele Friedrich, James S Pankow, Matthias Nauck, Eric Boerwinkle, Alexander Teumer, Elizabeth Selvin, Anna Köttgen
1,5-anhydroglucitol (1,5-AG) is a biomarker of hyperglycemic excursions associated with diabetic complications. Because of its structural similarity to glucose, genetic studies of 1,5-AG can deliver complementary insights into glucose metabolism. We conducted genome-wide association studies of serum 1,5-AG concentrations in 7,550 European ancestry (EA) and 2,030 African American participants (AA) free of diagnosed diabetes from the ARIC Study. Seven loci in/near EFNA1/SLC50A1, MCM6/LCT, SI, MGAM, MGAM2, SLC5A10, and SLC5A1 showed genome-wide significant associations (P < 5 × 10(-8)) among EA participants, five of which were novel...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28574153/effects-of-dietary-carbohydrate-on-1-5-anhydroglucitol-in-a-population-without-diabetes-results-from-the-omnicarb-trial
#4
S P Juraschek, E R Miller, L J Appel, R H Christenson, F M Sacks, E Selvin
AIMS: To characterize the determinants of 1,5-anhydroglucitol in people without diabetes and to determine the effects of dietary changes in amount and type of carbohydrate on 1,5-anhydroglucitol levels. METHODS: We conducted an ancillary study to a completed, randomized clinical trial in overweight and obese adults without diabetes (N=159). Using a crossover design, participants were fed each one of four diets in turn for 5 weeks, with 2-week washout periods inbetween...
June 2, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28535187/serum-levels-of-1-5-anhydroglucitol-and-risk-of-incident-end-stage-renal-disease
#5
Casey M Rebholz, Morgan E Grams, Yuan Chen, Alden L Gross, Yingying Sang, Josef Coresh, Elizabeth Selvin
Glycemic excursions, independent of average glucose, have been implicated in the development of diabetic implications. It is unknown if low 1,5-anyhydroglucitol (1,5-AG) are associated with advanced stages of kidney disease independent of kidney function and glycemia. In the Atherosclerosis Risk in Communities Study (N = 13,277), we used structural equation modeling to estimate the association between serum 1,5-AG levels and end-stage renal disease from baseline (1990-1992) through 2013 with adjustment for demographics, risk factors, a latent variable for glycemia (diabetes status, fasting glucose, hemoglobin A1c, fructosamine, glycated albumin), and a latent variable for kidney function (creatinine, cystatin C, β2-microglobulin)...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28500217/glucose-peaks-and-the-risk-of-dementia-and-20-year-cognitive-decline
#6
Andreea M Rawlings, A Richey Sharrett, Thomas H Mosley, Shoshana H Ballew, Jennifer A Deal, Elizabeth Selvin
OBJECTIVE: Hemoglobin A1c (HbA1c), a measure of average blood glucose level, is associated with the risk of dementia and cognitive impairment. However, the role of glycemic variability or glucose excursions in this association is unclear. We examined the association of glucose peaks in midlife, as determined by the measurement of 1,5-anhydroglucitol (1,5-AG) level, with the risk of dementia and 20-year cognitive decline. RESEARCH DESIGN AND METHODS: Nearly 13,000 participants from the Atherosclerosis Risk in Communities (ARIC) study were examined...
May 12, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28439964/global-and-targeted-metabolomics-of-synovial-fluid-discovers-special-osteoarthritis-metabolites
#7
Kaidi Zheng, Shanmin Ni, Huaijun Chen, Shenmin Lou, Mengting Hu, Li Sun, Xinyu Yang
PURPOSE: To identify special metabolites in synovial fluid of osteoarthritis (OA) via a metabolomics approach. METHOD: Synovial fluid of 35 participants (25 OA patients and 10 controls) was detected by GC-TOF/MS and multivariate data analysis was applied to analyze correlation among the observations. Different metabolites were screened by VIP value (VIP > 1), student t test (p < 0.05), and fold change (fold > 1.5), and verified with the standard metabolites in the synovial fluid of 24 OA patients and 11 controls by LC/MS...
April 25, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28281675/excretion-rates-of-1-5-anhydro-d-glucitol-uric-acid-and-microalbuminuria-as-glycemic-control-indexes-in-patients-with-type-2-diabetes
#8
Cong Ma, Junqin Sheng, Zhiwen Liu, Minghao Guo
1,5-anhydroglucitol (1,5-AG), uric acid and urinary proteins are excreted into the urine with increasing glucosuria. In the present retrospective study we analyzed whether these factors could be used as indicators for type 2 diabetes mellitus (T2DM) glucose control in 6,766 (T2DM) patients. There were 3,988 cases (58.9%) with HbA1c ≤ 6.5%, 853 cases (12.61%) with HbA1c levels ranging from 6.5% to 7% and 1,925 cases (28.5%) with HbA1c > 7%. HbA1c percentages were correlated with age, MA and 1,5-AG serum concentrations (P < 0...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28260702/effects-of-50-mg-vildagliptin-twice-daily-vs-50-mg-sitagliptin-once-daily-on-blood-glucose-fluctuations-evaluated-by-long-term-self-monitoring-of-blood-glucose
#9
Hiroshi Nomoto, Kimihiko Kimachi, Hideaki Miyoshi, Hiraku Kameda, Kyu Yong Cho, Akinobu Nakamura, So Nagai, Takuma Kondo, Tatsuya Atsumi
To date, several clinical trials have compared differences in glucose fluctuation observed with dipeptidyl peptidase-4 inhibitor treatment in patients with type 2 diabetes mellitus. However, most patients were assessed for limited periods or during hospitalization. The aim of the present study was to evaluate the effects of switching from sitagliptin to vildagliptin, or vice versa, on 12-week glucose fluctuations using self-monitoring of blood glucose in the standard care setting. We conducted a multicenter, prospective, open-label controlled trial in Japanese patients with type 2 diabetes...
April 29, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28242866/cross-over-study-comparing-postprandial-glycemic-increase-after-addition-of-a-fixed-dose-mitiglinide-voglibose-combination-or-a-dipeptidyl-peptidase-4-inhibitor-to-basal-insulin-therapy-in-patients-with-type-2-diabetes-mellitus
#10
RANDOMIZED CONTROLLED TRIAL
Noriko Ihana-Sugiyama, Ritsuko Yamamoto-Honda, Takehiro Sugiyama, Tetsuro Tsujimoto, Masafumi Kakei, Mitsuhiko Noda
BACKGROUND Although the efficacy of combination therapy consisting of basal insulin and oral hypoglycemic agents (OHAs) has been shown, which OHAs are the most efficient remains unclear. MATERIAL AND METHODS Five patients with type 2 diabetes were enrolled and treated with insulin degludec and metformin as a basal therapy. The patients were randomized in a cross-over fashion to receive a combination of mitiglinide (10 mg) and voglibose (0.2 mg) (M+V) 3 times daily or linagliptin (5 mg) (L) once daily for 8 weeks...
February 28, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28210869/serum-1-5-anhydroglucitol-levels-slightly-increase-rather-than-decrease-after-a-glucose-load-in-subjects-with-different-glucose-tolerance-status
#11
Hang Su, Xiaojing Ma, Jun Yin, Yufei Wang, Xingxing He, Yuqian Bao, Jian Zhou, Weiping Jia
AIMS: Previous studies showed that serum 1,5-anhydroglucitol (1,5-AG) levels are significantly reduced in patients with diabetes mellitus (DM). However, it remains unclear how 1,5-AG levels acutely change in response to a glucose load. This study explored acute changes in 1,5-AG levels after a glucose load and the related influencing factors in individuals with differing degrees of glucose tolerance. METHODS: A total of 681 participants (353 without DM and 328 with DM) without a prior history of DM were enrolled...
May 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28210043/repeated-3-minute-stair-climbing-descending-exercise-after-a-meal-over-2-weeks-increases-serum-1-5-anhydroglucitol-levels-in-people-with-type-2-diabetes
#12
Hiroto Honda, Makoto Igaki, Yuki Hatanaka, Motoaki Komatsu, Shin-Ichiro Tanaka, Tetsuo Miki, Yumika Matsuki, Tetsuo Takaishi, Tatsuya Hayashi
[Purpose] The purpose of this study was to examine the hypoglycemic effect of a postprandial exercise program using brief stair climbing-descending exercise in people with type 2 diabetes. [Subjects and Methods] Seven males with uncomplicated type 2 diabetes (age 68.0 ± 3.7 years) performed two sets of stair climbing-descending exercise 60 and 120 min after each meal for the first 2 weeks but not for the following 2 weeks. Each set of exercise comprised 3-min of continuous repetition of climbing briskly to the second floor followed by slow waking down to the first floor in their home...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28179966/efficacy-and-safety-of-vildagliptin-as-an-add-on-therapy-in-inadequately-controlled-type-2-diabetes-patients-treated-with-basal-insulin
#13
Daisuke Saito, Akio Kanazawa, Nayumi Shigihara, Fumihiko Sato, Toyoyoshi Uchida, Junko Sato, Hiromasa Goto, Takeshi Miyatsuka, Fuki Ikeda, Takeshi Ogihara, Chie Ohmura, Hirotaka Watada
BACKGROUND: The aim of this study was to investigate the efficacy and safety of vildagliptin as an add-on therapy for patients with type 2 diabetes mellitus inadequately controlled with basal insulin. METHODS: Twenty-four patients treated with basal insulin and oral anti-diabetes drugs were randomly allocated into two groups: the control group (did not receive any add-on drugs) and vildagliptin group (received vildagliptin 100 mg/day for 6 months). The primary outcome was changes in hemoglobin A1c (HbA1c) from baseline to end of study...
March 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27896445/serum-1-5-anhydroglucitol-level-as-a-screening-tool-for-diabetes-mellitus-in-a-community-based-population-at-high-risk-of-diabetes
#14
Yao Wang, Yuexing Yuan, Yanli Zhang, Chenghao Lei, Yi Zhou, Jiajia He, Zilin Sun
AIMS: Early diagnosis of diabetes yields significant clinical benefits; however, currently available diagnostic tools for community-based population are limited. This study aimed to assess the value of serum 1,5-anhydroglucitol (1,5-AG) for the diagnosis and screening of diabetes mellitus in a community-based population at high risk of diabetes. METHODS: In this diagnostic test, 1170 participants underwent a 75-g oral glucose tolerance test. Venous blood samples were collected for fasting blood glucose (FBG), 2-h postprandial blood glucose (PBG), and glycosylated hemoglobin A1c (HbA1c) measurements...
May 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/27894787/safety-and-efficacy-of-liraglutide-treatment-in-japanese-type-2-diabetes-patients-after-acute-myocardial-infarction-a-non-randomized-interventional-pilot-trial
#15
Masataka Kajiwara, Atsushi Tanaka, Tomohiro Kawasaki, Koichi Nakao, Tomohiro Sakamoto, Shigeru Toyoda, Teruo Inoue, Nobuhiko Koga, Koichi Node
BACKGROUND: Glucagon-like peptide 1 analogs are expected to exert a cardio-protective action due to their effective glucose-lowering action and favorable potency on multifactorial metabolic pathways. However, the safety and tolerability of liraglutide treatment after a recent acute coronary syndrome (ACS) in Japanese patients with type 2 diabetes mellitus (T2DM) have yet to be fully established. METHODS: A total of eight T2DM patients were recruited within 2 weeks after the onset of a ST-elevation myocardial infarction (STEMI) followed by successful percutaneous coronary intervention (PCI)...
March 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/27873436/alternate-glycemic-markers-reflect-glycemic-variability-in-continuous-glucose-monitoring-in-youth-with-prediabetes-and-type-2-diabetes
#16
Christine L Chan, Laura Pyle, Megan M Kelsey, Lindsey Newnes, Amy Baumgartner, Philip S Zeitler, Kristen J Nadeau
OBJECTIVE: To determine whether the alternate glycemic markers, fructosamine (FA), glycated albumin (GA), and 1,5-anhydroglucitol (1,5AG), predict glycemic variability captured by continuous glucose monitoring (CGM) in obese youth with prediabetes and type 2 diabetes (T2D). STUDY DESIGN: Youth with BMI ≥85th%ile, 10-18 years, had collection of fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), FA, GA, and 1,5AG and 72 hours of CGM. Participants with HbA1c ≥5...
November 22, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27859632/the-establishment-of-biological-reference-intervals-of-nontraditional-glycemic-markers-in-a-chinese-population
#17
Qiang Zhou, De-Bao Shi, Li-Ying Lv
BACKGROUND: We established the reference intervals for glycated albumin (GA), fructosamine (FA), and 1,5-anhydroglucitol (1,5-AG) in a Chinese healthy population. METHODS: This study enrolled a total of 458 eligible reference individuals, consisted of 226 men and 232 women, aged from 20~79 years (median age 43 years), who attending routine healthy checks. We stratified the subjects according to gender (males and females) and age (20-39, 40-59, and 60-79 years), and combined statistical methods with Lahti algorithm, as well as appropriate clinical consideration, to judge whether partitioning for data was needed...
November 17, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27730082/relationship-of-glycemic-control-markers-1-5-anhydroglucitol-fructosamine-and-glycated-hemoglobin-among-asian-indians-with-different-degrees-of-glucose-intolerance
#18
Thyparambil Aravindakshan Pramodkumar, Ramamoorthy Jayashri, Kuppan Gokulakrishnan, Kaliyaperumal Velmurugan, Rajendra Pradeepa, Ranjit Mohan Anjana, Viswanathan Mohan
OBJECTIVE: 1,5 anhydroglucitol (1,5 AG) is emerging as a marker of short-term glycemic control. We measured levels of 1,5 AG, fructosamine (FA), and glycated hemoglobin (HbA1c) in Asian Indians with different degrees of glucose intolerance. MATERIALS AND METHODS: We recruited 210 individuals with normal glucose tolerance (NGT; n = 60), impaired glucose tolerance (IGT; n = 50), and Type 2 diabetes mellitus (T2DM; n = 100) from a large tertiary diabetes center in Chennai in Southern India...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27729086/low-and-exacerbated-levels-of-1-5-anhydroglucitol-are-associated-with-cardiovascular-events-in-patients-after-first-time-elective-percutaneous-coronary-intervention
#19
Shuhei Takahashi, Kazunori Shimada, Katsumi Miyauchi, Tetsuro Miyazaki, Eiryu Sai, Manabu Ogita, Shuta Tsuboi, Hiroshi Tamura, Shinya Okazaki, Tomoyuki Shiozawa, Shohei Ouchi, Tatsuro Aikawa, Tomoyasu Kadoguchi, Hamad Al Shahi, Takuma Yoshihara, Makoto Hiki, Kikuo Isoda, Hiroyuki Daida
BACKGROUND: Postprandial hyperglycemia plays an important role in the pathogenesis of coronary artery disease and cardiovascular events. Serum 1,5-anhydroglucitol (1,5-AG) levels are known to be a clinical marker of postprandial hyperglycemia. However, the impact of 1,5-AG level on cardiovascular events has not been fully investigated. METHODS: We enrolled 240 consecutive patients who had undergone first-time elective percutaneous coronary intervention (PCI) with follow-up angiography within 1 year...
October 11, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27705886/annals-express-alcohol-consumption-reduces-hba1c-and-glycated-albumin-levels-but-not-1-5-anhydroglucitol
#20
Masafumi Koga, Rie Matsumoto
BACKGROUNDS: The effect of alcohol consumption on glycemic control indicators is not well known. In this study, we studied the effect of alcohol consumption on the plasma glucose and glycemic control indicators in non-diabetic men. METHODS: The study enrolled 300 non-diabetic men who received a complete medical checkup [age: 52.8 ± 6.5 years, body mass index (BMI): 24.4 ± 2.8 kg/m(2)]. The subjects were divided into four groups by the amount of alcohol consumed, and the plasma glucose, HbA1c, glycated albumin (GA), and 1,5-anhydroglucitol (1,5-AG) levels of the groups were compared...
October 4, 2016: Annals of Clinical Biochemistry
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