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1,5-Anhydroglucitol

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https://www.readbyqxmd.com/read/29466711/colorimetric-detection-of-1-5-anhydroglucitol-based-on-graphene-quantum-dots-and-enzyme-catalyzed-reaction
#1
Zhide Zhou, Le Zhao, Zhihong Wang, Wen Xue, Yunxiao Wang, Yong Huang, Jintao Liang, Jiejing Chen, Guiyin Li
Early diagnosis of diabetes yields significant clinical benefits. The serum level of 1,5‑anhydroglucitol (1,5‑AG) has been a new biochemical marker for postprandial hyperglycemia. In this study, a simple colorimetric method for 1,5‑AG detection has been designed based on highly efficient peroxidase mimetic activity of GQDs and enzyme-catalyzed reaction. By the catalytic action of pyranose oxidase (PROD), the 1,5‑AG was oxidized to 1,5‑anhydrofuctose and H2 O2 . The GQDs in the presence of H2 O2 exhibited highly efficient catalytic activity toward the oxidation of 3, 3', 5, 5'‑tetramethylbenzidine (TMB) to a blue colored product...
February 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29436378/establishment-of-community-based-reference-intervals-for-fructosamine-glycated-albumin-and-1-5-anhydroglucitol
#2
Elizabeth Selvin, Bethany Warren, Xintong He, David B Sacks, Amy K Saenger
BACKGROUND: There is growing interest in fructosamine, glycated albumin, and 1,5-anhydroglucitol (1,5-AG) as alternative measures of hyperglycemia, particularly for use in settings where traditional measures (glucose and HbA1c) are problematic or where intermediate (2-4 weeks) glycemic control is of interest. However, reference intervals for these alternative biomarkers are not established. METHODS: We measured fructosamine, glycated albumin, and 1,5-AG in a community-based sample of US black and white adults who participated in the Atherosclerosis Risk in Communities (ARIC) Study...
February 7, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29416575/a-randomized-controlled-trial-of-a-mini-low-carbohydrate-diet-and-an-energy-controlled-diet-among-japanese-patients-with-type-2-diabetes
#3
Masayo Kimura, Yoshinobu Kondo, Kazutaka Aoki, Jun Shirakawa, Hiroshi Kamiyama, Kazunari Kamiko, Shigeru Nakajima, Yasuo Terauchi
Background: Low-carbohydrate diets have been shown to effectively improve the metabolic status of patients with type 2 diabetes mellitus. However, patients may find it challenging to maintain a strict low-carbohydrate diet. The objective of this study was to determine if a one-meal, low-carbohydrate diet is as effective in improving metabolic status as a conventional, energy-restricted diet among patients with type 2 diabetes mellitus. Methods: In this 12-week randomized controlled study, the primary endpoint was differences in the changes of plasma glycosylated hemoglobin (HbA1c) levels between the two experimental groups...
March 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29371234/disordered-eating-behaviors-are-not-increased-by-an-intervention-to-improve-diet-quality-but-are-associated-with-poorer-glycemic-control-among-youth-with-type-1-diabetes
#4
Miriam H Eisenberg Colman, Virginia M Quick, Leah M Lipsky, Katherine W Dempster, Aiyi Liu, Lori M B Laffel, Sanjeev N Mehta, Tonja R Nansel
OBJECTIVE: This study examines whether participation in an 18-month behavioral intervention shown previously to improve overall diet quality inadvertently increases disordered eating behaviors (DEBs) in youth with type 1 diabetes and investigates the association of DEB with multiple measures of glycemic control and variability. RESEARCH DESIGN AND METHODS: Participants reported DEB and diabetes management at baseline and 6, 12, and 18 months; masked continuous glucose monitoring (CGM), HbA1c, and 1,5-anhydroglucitol were obtained concurrently...
January 25, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29328940/first-trimester-serum-biomarkers-to-predict-gestational-diabetes-in-a-high-risk-cohort-striving-for-clinically-useful-thresholds
#5
Siobhan M Corcoran, Natalie Achamallah, John O' Loughlin, Philip Stafford, Pat Dicker, Fergal D Malone, Fionnuala Breathnach
OBJECTIVES: Screening and diagnosis of gestational diabetes (GDM) has been a source of controversy. The prevalence has increased in line with an obesity epidemic and a trend towards delayed child-bearing. Treatment of even modest glycaemic impairment in pregnancy has been shown to be beneficial in preventing its clinical sequalae. However the cumbersome nature and timing of the oral glucose tolerance test coupled with debate around universal versus risk factor based screening have been problematic...
March 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29318370/the-metabolism-and-transport-of-1-5-anhydroglucitol-in-cells
#6
Lingwen Ying, Xiaojing Ma, Jun Yin, Yufei Wang, Xingxing He, Jiahui Peng, Yuqian Bao, Jian Zhou, Weiping Jia
AIMS: Our previous studies demonstrated that serum 1,5-anhydroglucitol (1,5-AG) levels increased slightly rather than declined after an acute glucose load. Therefore, the current study aims at exploring the transport and metabolic characteristics of 1,5-AG, as well as the effect of glucose on 1,5-AG transport. METHODS: Km and Vmax were determined to measure the affinity of glucose oxidase (GOD) and hexokinase (HK) for 1,5-AG and glucose. HepG2, C2C12, and primary mouse hepatocytes were incubated for 2 h with 1,5-AG at concentrations of 0, 80, and 160 μg/mL...
January 9, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29279271/challenges-in-diagnosing-and-monitoring-diabetes-in-patients-with-chronic-liver-diseases
#7
REVIEW
Telma E Silva, Marcelo F Ronsoni, Leonardo L Schiavon
The prevalence and mortality of diabetes mellitus and liver disease have risen in recent years. The liver plays an important role in glucose homeostasis, and various chronic liver diseases have a negative effect on glucose metabolism with the consequent emergence of diabetes. Some aspects related to chronic liver disease can affect diagnostic tools and the monitoring of diabetes and other glucose metabolism disorders, and clinicians must be aware of these limitations in their daily practice. In cirrhotic patients, fasting glucose may be normal in up until 23% of diabetes cases, and glycated hemoglobin provides falsely low results, especially in advanced cirrhosis...
December 20, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29238514/diagnostic-value-of-glycemic-markers-hba1c-1-5-anhydroglucitol-and-glycated-albumin-in-evaluating-gestational-diabetes-mellitus
#8
Baris Saglam, Sezer Uysal, Sadik Sozdinler, Omer Erbil Dogan, Banu Onvural
Background: The oral glucose tolerance test (OGTT) is the current established method performed worldwide to diagnose gestational diabetes mellitus (GDM). The purpose of this study was to assess the utility of the use of long- and short-term markers of glycemic status. Methods: The study group was composed of 80 pregnant women, 40 with GDM and 40 with normal glucose tolerance. GDM was diagnosed with the American Diabetes Association criteria. Glycemic markers were measured in the OGTT blood samples of women at 24-28 weeks of gestation...
December 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29157245/low-1-5-anhydroglucitol-levels-are-associated-with-long-term-cardiac-mortality-in-acute-coronary-syndrome-patients-with-hemoglobin-a1c-levels-less-than-7-0
#9
Shohei Ouchi, Kazunori Shimada, Tetsuro Miyazaki, Shuhei Takahashi, Yurina Sugita, Megumi Shimizu, Azusa Murata, Tomoyasu Kadoguchi, Takao Kato, Tatsuro Aikawa, Shoko Suda, Eiryu Sai, Masaru Hiki, Hiroshi Iwata, Takatoshi Kasai, Katsumi Miyauchi, Hiroyuki Daida
BACKGROUND: Diabetes mellitus is considered an important risk factor for cardiovascular diseases. High hemoglobin A1c (HbA1c) levels, which indicate poor glycemic control, have been associated with occurrence of cardiovascular diseases. There are few parameters which can predict cardiovascular risk in patients with well-controlled diabetes. Low 1,5-anhydroglucitol (1,5-AG) levels are considered a clinical marker of postprandial hyperglycemia. We hypothesized that low 1,5-AG levels could predict long-term mortality in acute coronary syndrome (ACS) patients with relatively low HbA1c levels...
November 21, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29104592/comparative-agreement-analysis-of-differences-in-1-5-anhydroglucitol-glycated-albumin-and-glycated-hemoglobin-a1c-levels-between-fasting-and-postprandial-states-in-steamed-bread-meal-test
#10
Hang Su, Yufei Wang, Xiaojing Ma, Xingxing He, Lingwen Ying, Junling Tang, Lu Dong, Yuqian Bao, Jian Zhou, Weiping Jia
Background: Our previous study indicated that serum 1,5-anhydroglucitol (1,5-AG) levels slightly increased after a glucose load; therefore, this study was conducted to explore short-term changes in 1,5-AG levels after a steamed bread meal test (SBMT) and compare the agreement of 1,5-AG, glycated albumin (GA), and glycated hemoglobin A1c (HbA1c) levels between fasting and postprandial states after an SBMT. Methods: 104 participants were recruited and underwent a 100 g SBMT...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29073616/serum-1-5-anhydroglucitol-risk-factor-of-acute-ischemic-stroke-and-transient-ischemic-attack-in-well-controlled-diabetes
#11
Yuji Shiga, Masaru Kuriyama, Yuhei Kanaya, Shinichi Takeshima, Makoto Takemaru, Kazuhiro Takamatsu, Yutaka Shimoe, Yasunori Fujikawa, Masakazu Nishigaki
BACKGROUND: Serum 1,5-anhydroglucitol (1,5-AG) levels are a measure that provides information on daily glycemic variations. We evaluated whether 1,5-AG could be a possible marker of acute ischemic stroke (AIS) or transient ischemic attacks (TIA) in patients with diabetes mellitus (DM). METHODS: We retrospectively reviewed electronic medical records of 5,294 AIS/TIA patients. Of the 5,294, 1,898 had diabetes and in 1,246, serum 1,5-AG levels were measured (group S)...
October 26, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29057494/a-decrease-in-serum-1-5-anhydroglucitol-levels-is-associated-with-the-presence-of-a-first-degree-family-history-of-diabetes-in-a-chinese-population-with-normal-glucose-tolerance
#12
X Hu, X He, X Ma, H Su, L Ying, J Peng, Y Wang, Y Bao, J Zhou, W Jia
AIM: This study aimed to investigate alterations in HbA1c , glycated albumin (GA) and 1,5-anhydroglucitol (1,5-AG) in Chinese first-degree relatives of individuals with diabetes (FDR) in pursuit of an index for early screening of glucose metabolism disturbance. METHODS: A total of 467 participants (age range: 20-78 years) with normal weight and normal glucose tolerance, as determined by a 75-g oral glucose tolerance test, were enrolled. HbA1c was measured using high-pressure liquid chromatography...
October 23, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29044407/corrigendum-for-1-5-anhydroglucitol-in-saliva-is-a-noninvasive-marker-of-short-term-glycemic-control
#13
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28971980/metabolomic-alterations-associated-with-cause-of-ckd
#14
Morgan E Grams, Adrienne Tin, Casey M Rebholz, Tariq Shafi, Anna Köttgen, Ronald D Perrone, Mark J Sarnak, Lesley A Inker, Andrew S Levey, Josef Coresh
BACKGROUND AND OBJECTIVES: Causes of CKD differ in prognosis and treatment. Metabolomic indicators of CKD cause may provide clues regarding the different physiologic processes underlying CKD development and progression. DESIGN, SETTING, PARTICIPANTS & MEASUREMENTS: Metabolites were quantified from serum samples of participants in the Modification of Diet in Renal Disease (MDRD) Study, a randomized controlled trial of dietary protein restriction and BP control, using untargeted reverse phase ultraperformance liquid chromatography tandem mass spectrometry quantification...
November 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28956034/metabolomics-reveal-mitochondrial-and-fatty-acid-metabolism-disorders-that-contribute-to-the-development-of-dkd-in-t2dm-patients
#15
Ling Li, Chengshi Wang, Hongliu Yang, Shuyun Liu, Yanrong Lu, Ping Fu, Jingping Liu
Diabetic kidney disease (DKD) is the leading cause of ESRD; however, early intervention can greatly prevent the progression of DKD; thus, sensitive biomarkers for DKD are still required. This study was aimed at the identification of potential biomarkers and revelation of underlying pathways in DKD patients by non-targeted metabolomics. Gas chromatography-mass spectrometry was used to analyze urine obtained from the control and type 2 diabetes mellitus (T2DM) and DKD patients, and the renal histological changes in DKD patients were assessed...
October 24, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28931928/serum-1-5-anhydroglucitol-when-used-with-fasting-plasma-glucose-improves-the-efficiency-of-diabetes-screening-in-a-chinese-population
#16
Lingwen Ying, Xingxing He, Xiaojing Ma, Yun Shen, Hang Su, Jiahui Peng, Yufei Wang, Yuqian Bao, Jian Zhou, Weiping Jia
Serum 1,5-anhydroglucitol (1,5-AG) levels can not only accurately reflect the mean blood glucose over the previous 1-2 weeks in diabetic patients but also offers the advantage of representing postprandial glucose. To evaluate the clinical significance of 1,5-AG in diabetes detection, especially when used in combination with fasting plasma glucose (FPG), a total of 3098 participants at high risk for diabetes (1467 men, 1631 women) were enrolled. A total of 1471 (47.5%) participants were diagnosed with diabetes, and the mean 1,5-AG level in the diabetic group was significantly lower than that in non-diabetic group [12...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928117/risk-factors-for-severe-hypoglycemia-in-black-and-white-adults-with-diabetes-the-atherosclerosis-risk-in-communities-aric-study
#17
Alexandra K Lee, Clare J Lee, Elbert S Huang, A Richey Sharrett, Josef Coresh, Elizabeth Selvin
OBJECTIVE: Severe hypoglycemia is a rare but important complication of type 2 diabetes. Few studies have examined the epidemiology of hypoglycemia in a community-based population. RESEARCH DESIGN AND METHODS: We included 1,206 Atherosclerosis Risk in Communities (ARIC) Study participants with diagnosed diabetes (baseline, 1996-1998). Severe hypoglycemic events were identified through 2013 by ICD-9 codes from claims for hospitalizations, emergency department visits, and ambulance use...
September 19, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28821595/a-computational-model-of-1-5-ag-dynamics-during-pregnancy
#18
Seyedeh M Zekavat, Slava Butkovich, Grace J Young, David M Nathan, Danny Petrasek
The importance of 1,5-anhydroglucitol (1,5-AG) as an intermediate biomarker for diabetic pregnancy is multi-fold: (1) it serves as a reliable indicator of moderate-level glycemic control, especially during early gestation; (2) it has been associated with increased risk of diabetes, independent of HbA1c and fasting glucose; and (3) it is an independent risk factor for the development of eclampsia during pregnancy. However, the clinical use of this biomarker during pregnancy has been underutilized due to physiological changes in glomerular filtration rate, plasma volume, and other hemodynamic parameters which have been hypothesized to bias gestational serum 1,5-AG concentrations...
August 2017: Physiological Reports
https://www.readbyqxmd.com/read/28820081/effects-of-1-5-anhydroglucitol-on-postprandial-blood-glucose-and-insulin-levels-and-hydrogen-excretion-in-rats-and-healthy-humans
#19
Sadako Nakamura, Kenichi Tanabe, Kazuhiro Yoshinaga, Fumio Shimura, Tsuneyuki Oku
The inhibition by 1,5-anhydro-d-glucitol (1,5-AG) was determined on disaccharidases of rats and humans. Then, the metabolism and fate of 1,5-AG was investigated in rats and humans. Although 1,5-AG inhibited about 50 % of sucrase activity in rat small intestine, the inhibition was less than half of d-sorbose. 1,5-AG strongly inhibited trehalase and lactase, whereas d-sorbose inhibited them very weakly. 1,5-AG noncompetitively inhibited sucrase. The inhibition of 1,5-AG on sucrase and maltase was similar between humans and rats...
July 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28799767/comprehensive-metabolomics-study-to-assess-longitudinal-biochemical-changes-and-potential-early-biomarkers-in-nonobese-diabetic-mice-that-progress-to-diabetes
#20
Peter Buchwald, Alejandro Tamayo-Garcia, Sivapriya Ramamoorthy, Marta Garcia-Contreras, Armando J Mendez, Camillo Ricordi
A global nontargeted longitudinal metabolomics study was carried out in male and female NOD mice to characterize the time-profile of the changes in the metabolic signature caused by onset of type 1 diabetes (T1D) and identify possible early biomarkers in T1D progressors. Metabolomics profiling of samples collected at five different time-points identified 676 and 706 biochemicals in blood and feces, respectively. Several metabolites were expressed at significantly different levels in progressors at all time-points, and their proportion increased strongly following onset of hyperglycemia...
August 29, 2017: Journal of Proteome Research
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