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1,5-Anhydroglucitol

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https://www.readbyqxmd.com/read/28281675/excretion-rates-of-1-5-anhydro-d-glucitol-uric-acid-and-microalbuminuria-as-glycemic-control-indexes-in-patients-with-type-2-diabetes
#1
Cong Ma, Junqin Sheng, Zhiwen Liu, Minghao Guo
1,5-anhydroglucitol (1,5-AG), uric acid and urinary proteins are excreted into the urine with increasing glucosuria. In the present retrospective study we analyzed whether these factors could be used as indicators for type 2 diabetes mellitus (T2DM) glucose control in 6,766 (T2DM) patients. There were 3,988 cases (58.9%) with HbA1c ≤ 6.5%, 853 cases (12.61%) with HbA1c levels ranging from 6.5% to 7% and 1,925 cases (28.5%) with HbA1c > 7%. HbA1c percentages were correlated with age, MA and 1,5-AG serum concentrations (P < 0...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28260702/effects-of-50-mg-vildagliptin-twice-daily-vs-50-mg-sitagliptin-once-daily-on-blood-glucose-fluctuations-evaluated-by-long-term-self-monitoring-of-blood-glucose
#2
Hiroshi Nomoto, Kimihiko Kimachi, Hideaki Miyoshi, Hiraku Kameda, Kyu Yong Cho, Akinobu Nakamura, So Nagai, Takuma Kondo, Tatsuya Atsumi
To date, several clinical trials have compared differences in glucose fluctuation observed with dipeptidyl peptidase-4 inhibitor treatment in patients with type 2 diabetes mellitus. However, most patients were assessed for limited periods or during hospitalization. The aim of the present study was to evaluate the effects of switching from sitagliptin to vildagliptin, or vice versa, on 12-week glucose fluctuations using self-monitoring of blood glucose in the standard care setting. We conducted a multicenter, prospective, open-label controlled trial in Japanese patients with type 2 diabetes...
March 3, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28242866/cross-over-study-comparing-postprandial-glycemic-increase-after-addition-of-a-fixed-dose-mitiglinide-voglibose-combination-or-a-dipeptidyl-peptidase-4-inhibitor-to-basal-insulin-therapy-in-patients-with-type-2-diabetes-mellitus
#3
Noriko Ihana-Sugiyama, Ritsuko Yamamoto-Honda, Takehiro Sugiyama, Tetsuro Tsujimoto, Masafumi Kakei, Mitsuhiko Noda
BACKGROUND Although the efficacy of combination therapy consisting of basal insulin and oral hypoglycemic agents (OHAs) has been shown, which OHAs are the most efficient remains unclear. MATERIAL AND METHODS Five patients with type 2 diabetes were enrolled and treated with insulin degludec and metformin as a basal therapy. The patients were randomized in a cross-over fashion to receive a combination of mitiglinide (10 mg) and voglibose (0.2 mg) (M+V) 3 times daily or linagliptin (5 mg) (L) once daily for 8 weeks...
February 28, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28210869/serum-1-5-anhydroglucitol-levels-slightly-increase-rather-than-decrease-after-a-glucose-load-in-subjects-with-different-glucose-tolerance-status
#4
Hang Su, Xiaojing Ma, Jun Yin, Yufei Wang, Xingxing He, Yuqian Bao, Jian Zhou, Weiping Jia
AIMS: Previous studies showed that serum 1,5-anhydroglucitol (1,5-AG) levels are significantly reduced in patients with diabetes mellitus (DM). However, it remains unclear how 1,5-AG levels acutely change in response to a glucose load. This study explored acute changes in 1,5-AG levels after a glucose load and the related influencing factors in individuals with differing degrees of glucose tolerance. METHODS: A total of 681 participants (353 without DM and 328 with DM) without a prior history of DM were enrolled...
February 16, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28210043/repeated-3-minute-stair-climbing-descending-exercise-after-a-meal-over-2-weeks-increases-serum-1-5-anhydroglucitol-levels-in-people-with-type-2-diabetes
#5
Hiroto Honda, Makoto Igaki, Yuki Hatanaka, Motoaki Komatsu, Shin-Ichiro Tanaka, Tetsuo Miki, Yumika Matsuki, Tetsuo Takaishi, Tatsuya Hayashi
[Purpose] The purpose of this study was to examine the hypoglycemic effect of a postprandial exercise program using brief stair climbing-descending exercise in people with type 2 diabetes. [Subjects and Methods] Seven males with uncomplicated type 2 diabetes (age 68.0 ± 3.7 years) performed two sets of stair climbing-descending exercise 60 and 120 min after each meal for the first 2 weeks but not for the following 2 weeks. Each set of exercise comprised 3-min of continuous repetition of climbing briskly to the second floor followed by slow waking down to the first floor in their home...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28179966/efficacy-and-safety-of-vildagliptin-as-an-add-on-therapy-in-inadequately-controlled-type-2-diabetes-patients-treated-with-basal-insulin
#6
Daisuke Saito, Akio Kanazawa, Nayumi Shigihara, Fumihiko Sato, Toyoyoshi Uchida, Junko Sato, Hiromasa Goto, Takeshi Miyatsuka, Fuki Ikeda, Takeshi Ogihara, Chie Ohmura, Hirotaka Watada
BACKGROUND: The aim of this study was to investigate the efficacy and safety of vildagliptin as an add-on therapy for patients with type 2 diabetes mellitus inadequately controlled with basal insulin. METHODS: Twenty-four patients treated with basal insulin and oral anti-diabetes drugs were randomly allocated into two groups: the control group (did not receive any add-on drugs) and vildagliptin group (received vildagliptin 100 mg/day for 6 months). The primary outcome was changes in hemoglobin A1c (HbA1c) from baseline to end of study...
March 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27896445/serum-1-5-anhydroglucitol-level-as-a-screening-tool-for-diabetes-mellitus-in-a-community-based-population-at-high-risk-of-diabetes
#7
Yao Wang, Yuexing Yuan, Yanli Zhang, Chenghao Lei, Yi Zhou, Jiajia He, Zilin Sun
AIMS: Early diagnosis of diabetes yields significant clinical benefits; however, currently available diagnostic tools for community-based population are limited. This study aimed to assess the value of serum 1,5-anhydroglucitol (1,5-AG) for the diagnosis and screening of diabetes mellitus in a community-based population at high risk of diabetes. METHODS: In this diagnostic test, 1170 participants underwent a 75-g oral glucose tolerance test. Venous blood samples were collected for fasting blood glucose (FBG), 2-h postprandial blood glucose (PBG), and glycosylated hemoglobin A1c (HbA1c) measurements...
November 28, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27894787/safety-and-efficacy-of-liraglutide-treatment-in-japanese-type-2-diabetes-patients-after-acute-myocardial-infarction-a-non-randomized-interventional-pilot-trial
#8
Masataka Kajiwara, Atsushi Tanaka, Tomohiro Kawasaki, Koichi Nakao, Tomohiro Sakamoto, Shigeru Toyoda, Teruo Inoue, Nobuhiko Koga, Koichi Node
BACKGROUND: Glucagon-like peptide 1 analogs are expected to exert a cardio-protective action due to their effective glucose-lowering action and favorable potency on multifactorial metabolic pathways. However, the safety and tolerability of liraglutide treatment after a recent acute coronary syndrome (ACS) in Japanese patients with type 2 diabetes mellitus (T2DM) have yet to be fully established. METHODS: A total of eight T2DM patients were recruited within 2 weeks after the onset of a ST-elevation myocardial infarction (STEMI) followed by successful percutaneous coronary intervention (PCI)...
March 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/27873436/alternate-glycemic-markers-reflect-glycemic-variability-in-continuous-glucose-monitoring-in-youth-with-prediabetes-and-type-2-diabetes
#9
Christine L Chan, Laura Pyle, Megan M Kelsey, Lindsey Newnes, Amy Baumgartner, Philip S Zeitler, Kristen J Nadeau
OBJECTIVE: To determine whether the alternate glycemic markers, fructosamine (FA), glycated albumin (GA), and 1,5-anhydroglucitol (1,5AG), predict glycemic variability captured by continuous glucose monitoring (CGM) in obese youth with prediabetes and type 2 diabetes (T2D). STUDY DESIGN: Youth with BMI ≥85th%ile, 10-18 years, had collection of fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), FA, GA, and 1,5AG and 72 hours of CGM. Participants with HbA1c ≥5...
November 22, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27859632/the-establishment-of-biological-reference-intervals-of-nontraditional-glycemic-markers-in-a-chinese-population
#10
Qiang Zhou, De-Bao Shi, Li-Ying Lv
BACKGROUND: We established the reference intervals for glycated albumin (GA), fructosamine (FA), and 1,5-anhydroglucitol (1,5-AG) in a Chinese healthy population. METHODS: This study enrolled a total of 458 eligible reference individuals, consisted of 226 men and 232 women, aged from 20~79 years (median age 43 years), who attending routine healthy checks. We stratified the subjects according to gender (males and females) and age (20-39, 40-59, and 60-79 years), and combined statistical methods with Lahti algorithm, as well as appropriate clinical consideration, to judge whether partitioning for data was needed...
November 17, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27730082/relationship-of-glycemic-control-markers-1-5-anhydroglucitol-fructosamine-and-glycated-hemoglobin-among-asian-indians-with-different-degrees-of-glucose-intolerance
#11
Thyparambil Aravindakshan Pramodkumar, Ramamoorthy Jayashri, Kuppan Gokulakrishnan, Kaliyaperumal Velmurugan, Rajendra Pradeepa, Ranjit Mohan Anjana, Viswanathan Mohan
OBJECTIVE: 1,5 anhydroglucitol (1,5 AG) is emerging as a marker of short-term glycemic control. We measured levels of 1,5 AG, fructosamine (FA), and glycated hemoglobin (HbA1c) in Asian Indians with different degrees of glucose intolerance. MATERIALS AND METHODS: We recruited 210 individuals with normal glucose tolerance (NGT; n = 60), impaired glucose tolerance (IGT; n = 50), and Type 2 diabetes mellitus (T2DM; n = 100) from a large tertiary diabetes center in Chennai in Southern India...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27729086/low-and-exacerbated-levels-of-1-5-anhydroglucitol-are-associated-with-cardiovascular-events-in-patients-after-first-time-elective-percutaneous-coronary-intervention
#12
Shuhei Takahashi, Kazunori Shimada, Katsumi Miyauchi, Tetsuro Miyazaki, Eiryu Sai, Manabu Ogita, Shuta Tsuboi, Hiroshi Tamura, Shinya Okazaki, Tomoyuki Shiozawa, Shohei Ouchi, Tatsuro Aikawa, Tomoyasu Kadoguchi, Hamad Al Shahi, Takuma Yoshihara, Makoto Hiki, Kikuo Isoda, Hiroyuki Daida
BACKGROUND: Postprandial hyperglycemia plays an important role in the pathogenesis of coronary artery disease and cardiovascular events. Serum 1,5-anhydroglucitol (1,5-AG) levels are known to be a clinical marker of postprandial hyperglycemia. However, the impact of 1,5-AG level on cardiovascular events has not been fully investigated. METHODS: We enrolled 240 consecutive patients who had undergone first-time elective percutaneous coronary intervention (PCI) with follow-up angiography within 1 year...
October 11, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27705886/annals-express-alcohol-consumption-reduces-hba1c-and-glycated-albumin-levels-but-not-1-5-anhydroglucitol
#13
Masafumi Koga, Rie Matsumoto
BACKGROUNDS: The effect of alcohol consumption on glycemic control indicators is not well known. In this study, we studied the effect of alcohol consumption on the plasma glucose and glycemic control indicators in non-diabetic men. METHODS: The study enrolled 300 non-diabetic men who received a complete medical checkup [age: 52.8 ± 6.5 years, body mass index (BMI): 24.4 ± 2.8 kg/m(2)]. The subjects were divided into four groups by the amount of alcohol consumed, and the plasma glucose, HbA1c, glycated albumin (GA), and 1,5-anhydroglucitol (1,5-AG) levels of the groups were compared...
October 4, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27525365/glycemic-control-and-variability-in-association-with-body-mass-index-and-body-composition-over-18months-in-youth-with-type-1-diabetes
#14
RANDOMIZED CONTROLLED TRIAL
Leah M Lipsky, Benjamin Gee, Aiyi Liu, Tonja R Nansel
AIMS: The impact of adiposity on glycemic control in type 1 diabetes patients has important implications for preventing complications. This study examined associations of glycemic outcomes with body mass index (BMI, kg/m(2)) and body composition in youth with type 1 diabetes. METHODS: This is a secondary analysis of an 18-month randomized controlled dietary intervention trial (N=136, baseline age=12.3±2.5y, HbA1c=8.1±1.0% (65±11mmol/mol)). Measured height and weight every 3months were abstracted from medical records...
October 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27391168/factors-influencing-inter-day-glycemic-variability-in-diabetic-outpatients-receiving-insulin-therapy
#15
Hiroko Mori, Yosuke Okada, Akira Kurozumi, Manabu Narisawa, Yoshiya Tanaka
INTRODUCTION: The aim of the present study was to determine the actual state of inter-day glycemic variability and identify the factors that affect glycemic variability in diabetic outpatients on insulin therapy. MATERIALS AND METHODS: The participants were 45 outpatients with diabetes mellitus receiving insulin therapy. The mean plasma glucose (MPG) levels, intra-day glycemic variability (expressed by standard deviation and mean amplitude of glucose excursion) and inter-day glycemic variability (expressed by mean of daily differences [MODD] in blood glucose levels) were measured continuously over 7 days with iPro2(®) ...
January 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27354236/novel-insights-into-development-of-diabetic-bladder-disorder-provided-by-metabolomic-analysis-of-the-rat-nondiabetic-and-diabetic-detrusor-and-urothelial-layer
#16
Yi Wang, Gary G Deng, Kelvin P Davies
There are at present no published studies providing a global overview of changes in bladder metabolism resulting from diabetes. Such studies have the potential to provide mechanistic insight into the development of diabetic bladder disorder (DBD). In the present study, we compared the metabolome of detrusor and urothelial layer in a 1-mo streptozotocin-induced rat model of type 1 diabetes with nondiabetic controls. Our studies revealed that diabetes caused both common and differential changes in the detrusor and urothelial layer's metabolome...
August 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27335652/do-glycemic-marker-levels-vary-by-race-differing-results-from-a-cross-sectional-analysis-of-individuals-with-and-without-diagnosed-diabetes
#17
April P Carson, Paul Muntner, Elizabeth Selvin, Mercedes R Carnethon, Xuelin Li, Myron D Gross, W Timothy Garvey, Cora E Lewis
OBJECTIVE: It is well known that A1c varies by race. However, racial differences in other biomarkers of hyperglycemia are less well characterized. The objective of this study was to determine whether average levels of glycemic markers differ by race in adults with and without diagnosed diabetes, before and after accounting for postchallenge glucose. RESEARCH DESIGN AND METHODS: This cross-sectional study included 2692 middle-aged men and women (5.5% with diagnosed diabetes; 44% African-American; and 56% white) from the Coronary Artery Risk Development in Young Adults Study (2005-2006) who had fasting glucose, 2-hour postchallenge glucose, A1c, glycated albumin, fructosamine, and 1,5-anhydroglucitol (1,5-AG) measured...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27321316/the-association-of-serum-glycated-albumin-with-the-prevalence-of-diabetic-retinopathy-in-korean-patients-with-type-2-diabetes-mellitus
#18
Won Seon Jeon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Cheol-Young Park
AIMS: To determine the clinical relationship between serum glycated albumin (GA) and diabetic retinopathy in Korean patients with type 2 diabetes mellitus (T2DM). METHODS: A cross-sectional study including 424 patients with T2DM was conducted. Patients were divided into groups based on the presence of diabetic retinopathy and tertiles of serum GA and 1,5-anhydroglucitol levels. RESULTS: Patients in the highest tertile of GA had a higher risk of diabetic retinopathy than those in the lowest tertile...
June 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27194309/greater-diet-quality-is-associated-with-more-optimal-glycemic-control-in-a-longitudinal-study-of-youth-with-type-1-diabetes
#19
Tonja R Nansel, Leah M Lipsky, Aiyi Liu
BACKGROUND: Despite the centrality of nutrition in the management of type 1 diabetes, the association of diet quality and macronutrient distribution with glycemic control is ambiguous. OBJECTIVE: This study examined longitudinally the association of dietary intake with multiple indicators of glycemic control in youth with type 1 diabetes participating in a behavioral nutrition intervention study. DESIGN: Participants in a randomized clinical trial of a behavioral nutrition intervention [n = 136; mean ± SD age: 12...
July 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27188855/measurement-of-1-5-anhydroglucitol-in-blood-and-saliva-from-non-targeted-metabolomics-to-biochemical-assay
#20
Anna Halama, Michal Kulinski, Sara Abdul Kader, Noothan J Satheesh, Abdul Badi Abou-Samra, Karsten Suhre, Ramzi M Mohammad
BACKGROUND: Diabetes testing using saliva, rather than blood and urine, could facilitate diabetes screening in public spaces. We previously identified 1,5-anhydro-D-glucitol (1,5-AG) in saliva as a diabetes biomarker. The Glycomark™ assay kit is FDA approved for 1,5-AG measurement in blood. Here we evaluated its applicability for 1,5-AG quantification in saliva. METHODS: Using pooled saliva samples, we validated Glycomark™ assay use with a RX Daytona(+) clinical chemistry analyser...
2016: Journal of Translational Medicine
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