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High Density lipoproteins

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https://www.readbyqxmd.com/read/28549315/associations-between-the-levels-of-thyroid-hormones-and-lipid-lipoprotein-levels-data-from-national-health-and-nutrition-examination-survey-2007-2012
#1
Ram B Jain
Data from National Health and Nutrition Examination Survey for the years 2007-2012 were used to investigate associations between thyroid hormones and lipid/lipoprotein levels for a representative sample of general US population aged ≥20 years. There were no statistically significant differences for adjusted high density lipoprotein levels among thyroid function groups, namely, subclinical hyperthyroid (SCHPR), clinical hyperthyroid (CHPR), euthyroid (EU), clinical hypothyroid (CHYP), and subclinical hypothyroid (SCHYP)...
May 4, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28549073/repeated-measurements-of-blood-pressure-and-cholesterol-improves-cardiovascular-disease-risk-prediction-an-individual-participant-data-meta-analysis
#2
Ellie Paige, Jessica Barrett, Lisa Pennells, Michael Sweeting, Peter Willeit, Emanuele Di Angelantonio, Vilmundur Gudnason, Børge G Nordestgaard, Bruce M Psaty, Uri Goldbourt, Lyle G Best, Gerd Assmann, Jukka T Salonen, Paul J Nietert, Wm Monique Verschuren, Eric J Brunner, Richard A Kronmal, Veikko Salomaa, Stephan Jl Bakker, Gilles R Dagenais, Shinichi Sato, Jan-Håkan Jansson, Johann Willeit, Altan Onat, Agustin Gómez de la Cámara, Ronan Roussel, Henry Völzke, Rachel Dankner, Robert W Tipping, Tom W Meade, Chiara Donfrancesco, Lewis H Kuller, Annette Peters, John Gallacher, Daan Kromhout, Hiroyasu Iso, Matthew Knuiman, Edoardo Casiglia, Maryam Kavousi, Luigi Palmieri, Johan Sundström, Barry R Davis, Inger Njølstad, David Couper, John Danesh, Simon G Thompson, Angela Wood
The added value of incorporating information from repeated measurements of blood pressure and cholesterol for cardiovascular disease (CVD) risk prediction has not been rigorously assessed. We used data from the Emerging Risk Factors Collaboration on 191,445 adults (38 cohorts from across 17 countries with data from 1962-2014) with > 1 million measurements of systolic blood pressure, total cholesterol and high-density lipoprotein cholesterol; over a median 12 years of follow-up, 21,170 CVD events occurred...
May 26, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28549070/the-atherogenic-index-of-plasma-and-the-risk-of-mortality-in-incident-dialysis-patients-results-from-a-nationwide-prospective-cohort-in-korea
#3
Mi Jung Lee, Jung Tak Park, Seung Hyeok Han, Yong-Lim Kim, Yon Su Kim, Chul Woo Yang, Nam-Ho Kim, Shin-Wook Kang, Hyung Jong Kim, Tae-Hyun Yoo
BACKGROUND: The atherogenic index of plasma (AIP), which is the logarithmic ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C), had a linear relationship with clinical outcomes in the general population. However, the association of each lipid profile, TG and HDL-C, with survival was not straightforward in dialysis patients. This non-linear association led us to further investigate the prognostic impact of the AIP in these patients. METHODS: From a nationwide prospective cohort, 1,174 incident dialysis patients were included...
2017: PloS One
https://www.readbyqxmd.com/read/28548560/microalgal-oil-from-schizochytrium-sp-prevents-hfd-induced-abdominal-fat-accumulation-in-mice
#4
Jinhui Yu, Yong Ma, Jie Sun, Liyuan Ran, Youwei Li, Ning Wang, Tao Yu, Wenting Gao, Wenbin Jia, Rujiao Jiang, Meihua Guo, Yuping Bi, Yingjie Wu
OBJECTIVE: Dietary n-3 polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acids (EPA) and docosahexaenoic acid (DHA), are proved to be effective in obesity reduction. Microalgal oil (MO) is an important alternative source of n-3 PUFAs that effectively alleviates obesity. The aim of the present study was to explore the anti-obesity effects of microalgal oil from Schizochytrium sp. (SMO) and to compare the effects of 2 SMOs (SMO1 and SMO2) with different levels of purity of n-3 PUFAs on high fat diet (HFD)-induced obesity in male C57BL/6J mice...
May 26, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28548292/hypertriglyceridemic-acute-pancreatitis-in-an-emergency-department-the-typical-clinical-features-and-genetic-variants
#5
Wan Jun Chen, Xiao Fan Sun, Rui Xue Zhang, Min Jie Xu, Tong Hai Dou, Xiao Bin Zhang, Min Zhong, Wei Qiang Yang, Li Liu, Xiao Ye Lu, Chang Qing Zhu
OBJECTIVE: To investigate the clinical characteristics of hypertriglyceridemic acute pancreatitis (HTGAP), and the molecular foundation contributing to the hypertriglyceridemia in this group of patients. METHODS: Clinical data from 329 patients with AP were collected and analyzed. All the patients were divided into 1) HTGAP group (n = 40), with fasting serum triglyceride ≥ 500 mg/dL; and 2) NHTGAP group (n = 289). Next, the targeted next-generation sequencing was applied in 11 HTGAP patients to detect the genetic mutation associated with hypertriglyceridemia that included apolipoprotein A-5 (APOA5), apolipoprotein C-3 (APOC3), apolipoprotein E (APOE), BLK proto-oncogene, lipoprotein lipase (LPL), apolipoprotein C-2 (APOC2), glycosylphosphatidylinositol anchored high density lipoprotein binding protein-1(GPIHBP1), and lipase maturation factor-1(LMF1)...
May 26, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28548243/cross-reactive-saliva-iga-antibodies-to-oxidized-ldl-and-periodontal-pathogens-in-humans
#6
Ramin Akhi, Chunguang Wang, Mikael Kyrklund, Outi Kummu, S Pauliina Turunen, Kati Hyvärinen, Arja Kullaa, Tuula Salo, Pirkko J Pussinen, Sohvi Hörkkö
AIM: Oxidized Low-Density Lipoproteins (oxLDL) are formed as a result of lipid peroxidation and are highly immunogenic and proatherogenic. In this study, saliva antibodies binding to oxLDL, Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa), were characterized and their cross reactivity was evaluated. MATERIAL & METHODS: Resting and stimulated saliva samples were collected from 36 healthy adults (mean age 26 years). Saliva IgA, IgG and IgM autoantibody levels to copper oxidized LDL (CuOx-LDL) and malondialdehyde acetaldehyde modified LDL (MAA-LDL), were determined with chemiluminescence immunoassay...
May 26, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28548082/whole-genome-sequencing-and-imputation-in-isolated-populations-identify-genetic-associations-with-medically-relevant-complex-traits
#7
Lorraine Southam, Arthur Gilly, Dániel Süveges, Aliki-Eleni Farmaki, Jeremy Schwartzentruber, Ioanna Tachmazidou, Angela Matchan, Nigel W Rayner, Emmanouil Tsafantakis, Maria Karaleftheri, Yali Xue, George Dedoussis, Eleftheria Zeggini
Next-generation association studies can be empowered by sequence-based imputation and by studying founder populations. Here we report ∼9.5 million variants from whole-genome sequencing (WGS) of a Cretan-isolated population, and show enrichment of rare and low-frequency variants with predicted functional consequences. We use a WGS-based imputation approach utilizing 10,422 reference haplotypes to perform genome-wide association analyses and observe 17 genome-wide significant, independent signals, including replicating evidence for association at eight novel low-frequency variant signals...
May 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28547796/high-serum-total-cholesterol-is-associated-with-suicide-mortality-in-japanese-women
#8
T Svensson, M Inoue, N Sawada, H Charvat, M Mimura, S Tsugane
OBJECTIVE: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times. METHOD: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (<4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl])...
May 26, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28546543/metabolic-profiling-of-polycystic-ovary-syndrome-reveals-interactions-with-abdominal-obesity
#9
Alexessander Couto Alves, Beatriz Valcarcel, Ville-Petteri Mäkinen, Laure Morin-Papunen, Sylvain Sebert, Antti J Kangas, Pasi Soininen, Shikta Das, Maria De Iorio, Lachlan Coin, Mika Ala-Korpela, Marjo-Riitta Järvelin, Stephen Franks
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance, and diabetes mellitus. Here we investigate whether changes in the metabolic profile of PCOS women are driven by increased tendency to obesity or are specific features of PCOS related to increased testosterone levels. DESIGN AND METHODS: We conducted an NMR metabolomics association study of PCOS cases (n=145) and controls (n=687) nested in a population-based birth cohort (n=3,127)...
May 26, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28546455/objectively-measured-sedentary-time-and-cardiovascular-risk-factor-control-in-us-hispanics-latinos-with-diabetes-mellitus-results-from-the-hispanic-community-health-study-study-of-latinos-hchs-sol
#10
Xueyin Wang, Garrett Strizich, Simin Hua, Daniela Sotres-Alvarez, Christina Buelna, Linda C Gallo, Marc D Gellman, Yasmin Mossavar-Rahmani, Matthew J O'Brien, Mark Stoutenberg, Tao Wang, M Larissa Avilés-Santa, Robert C Kaplan, Qibin Qi
BACKGROUND: Cardiovascular disease (CVD) risk factor control is a cornerstone of diabetes mellitus management. Little is known about relationships of objectively measured sedentary time and physical activity with major CVD risk factor control in individuals with diabetes mellitus. We examined associations of objectively measured sedentary time and moderate-to-vigorous physical activity with reaching major CVD risk factor control goals among US Hispanic/Latino adults with diabetes mellitus...
May 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28546217/increased-hepatic-expression-of-endothelial-lipase-inhibits-cholesterol-diet-induced-hypercholesterolemia-and-atherosclerosis-in-transgenic-rabbits
#11
Chuan Wang, Kazutoshi Nishijima, Shuji Kitajima, Manabu Niimi, Haizhao Yan, Yajie Chen, Bo Ning, Fumikazu Matsuhisa, Enqi Liu, Jifeng Zhang, Y Eugene Chen, Jianglin Fan
OBJECTIVE: Endothelial lipase (EL) is a key determinant in plasma high-density lipoprotein-cholesterol. However, functional roles of EL on the development of atherosclerosis have not been clarified. We investigated whether hepatic expression of EL affects plasma lipoprotein metabolism and cholesterol diet-induced atherosclerosis. APPROACH AND RESULTS: We generated transgenic (Tg) rabbits expressing the human EL gene in the liver and then examined the effects of EL expression on plasma lipids and lipoproteins and compared the susceptibility of Tg rabbits with cholesterol diet-induced atherosclerosis with non-Tg littermates...
May 25, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28545518/design-and-rationale-of-the-odyssey-dm-dyslipidemia-trial-lipid-lowering-efficacy-and-safety-of-alirocumab-in-individuals-with-type-2-diabetes-and-mixed-dyslipidaemia-at-high-cardiovascular-risk
#12
Dirk Müller-Wieland, Lawrence A Leiter, Bertrand Cariou, Alexia Letierce, Helen M Colhoun, Stefano Del Prato, Robert R Henry, Francisco J Tinahones, Lisa Aurand, Jaman Maroni, Kausik K Ray, Maja Bujas-Bobanovic
BACKGROUND: Type 2 diabetes mellitus (T2DM) is often associated with mixed dyslipidaemia, where non-high-density lipoprotein cholesterol (non-HDL-C) levels may more closely align with cardiovascular risk than low-density lipoprotein cholesterol (LDL-C). We describe the design and rationale of the ODYSSEY DM-DYSLIPIDEMIA study that assesses the efficacy and safety of alirocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, versus lipid-lowering usual care in individuals with T2DM and mixed dyslipidaemia at high cardiovascular risk with non-HDL-C inadequately controlled despite maximally tolerated statin therapy...
May 25, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28544753/no-association-between-metabolic-syndrome-and-radiographic-hand-osteoarthritis-data-from-the-framingham-study
#13
Mette P Strand, Tuhina Neogi, Jingbo Niu, David T Felson, Ida K Haugen
OBJECTIVE: To explore whether metabolic syndrome (MetS) and its components are associated with hand OA using longitudinal data from the Framingham study. METHODS: In our cross-sectional analyses we included 1089 persons (age 50-75 years), of whom 785 had 7-year longitudinal radiographs. Of these, 586 with no hand OA at baseline were included in analyses on hand OA incidence. We explored associations between and MetS and its components (central obesity, hypertension, diabetes, triglyceridemia, low high-density lipoprotein) and radiographic hand OA (defined as ≥2 interphalangeal joints with Kellgren-Lawrence grade≥2) using logistic regression analyses with adjustment for age, sex and body mass index (BMI)...
May 23, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28542805/downregulation-of-cholesteryl-ester-transfer-protein-by-glucocorticoids-a-randomized-study-on-hdl
#14
Jorien Werumeus Buning, Lidya G Dimova, Frank G Perton, Uwe J F Tietge, André P van Beek, Robin P F Dullaart
BACKGROUND: High density lipoprotein (HDL) cholesterol is not decreased in hypercortisolism despite high triglycerides, which may be ascribed to effects on the cholesteryl ester transfer protein (CETP) pathway. We explored if CETP mRNA expression is modulated by glucocorticoid treatment in vitro. Effects of doubling the hydrocortisone (HCT) replacement dose on plasma CETP activity and HDL characteristics were tested in patients with secondary adrenal insufficiency. MATERIALS AND METHODS: Human THP-1 macrophages were incubated with corticosterone in vitro in the presence or absence of a liver X receptor (LXR) agonist, followed by determination of CETP mRNA levels by quantitative real-time PCR...
May 24, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28542510/associations-among-apolipoproteins-oxidized-high-density-lipoprotein-and-cardiovascular-events-in-patients-on-hemodialysis
#15
Hirokazu Honda, Tsutomu Hirano, Masashi Ueda, Shiho Kojima, Shinichi Mashiba, Yasuyuki Hayase, Tetsuo Michihata, Kanji Shishido, Keiko Takahashi, Nozomu Hosaka, Misa Ikeda, Daisuke Sanada, Takanori Shibata
Apolipoproteins are associated with survival among patients on hemodialysis (HD), but these associations might be influenced by dysfunctional (oxidized) high-density lipoprotein (HDL). We assessed associations among apolipoproteins and oxidized HDL, mortality and cardiovascular disease (CVD) events in patients on HD. This prospective observational study examined 412 patients on prevalent HD. Blood samples were obtained before dialysis at baseline to measure lipids, apolipoproteins, oxidized LDL, oxidized HDL, high-sensitivity C-reactive protein (hs-CRP) and interleukin (IL)-6 at baseline, and HDL-C and hs-CRP were measured 12 months later...
2017: PloS One
https://www.readbyqxmd.com/read/28542499/lipidomic-and-metabolic-changes-in-the-p4-type-atpase-atp10d-deficient-c57bl-6j-wild-type-mice-upon-rescue-of-atp10d-function
#16
Alexander Sigruener, Christian Wolfrum, Alfred Boettcher, Thomas Kopf, Gerhard Liebisch, Evelyn Orsó, Gerd Schmitz
BACKGROUND: Sequence variants near the human gene for P4-type ATPase, class V, type 10D (ATP10D) were shown to significantly associate with circulating hexosylceramide d18:1/16:0 and d18:1/24:1 levels, obesity, insulin resistance, plasma high density lipoprotein (HDL), coronary stenotic index and intracranial atherosclerotic index. In mice Atp10d is associated with HDL modulation and C57BL/6 mice expressing a truncated, non-functional form of ATP10D easily develop obesity and insulin resistance on high-fat diet...
2017: PloS One
https://www.readbyqxmd.com/read/28540870/atorvastatin-as-adjunctive-therapy-for-chronic-plaque-type-psoriasis-versus-betamethasone-valerate-alone-a-randomized-double-blind-placebo-controlled-trial
#17
Sharlene Helene H Chua, Giselle Marie S Tioleco, Carmela Augusta F Dayrit, Winlove P Mojica, Belen L Dofitas, Lorna F Frez
BACKGROUND: Psoriasis is a T helper 1 cell-mediated chronic inflammation. Statins have been found to have anti-inflammatory and immunomodulatory effects targeting T helper 1 cells and thus, are being investigated as treatments for psoriasis. AIMS: To investigate the efficacy and safety of atorvastatin as adjunctive treatment for mild to moderate chronic plaque psoriasis; and the impact of atorvastatin on quality of life. The study also aimed to correlate the beneficial effects of atorvastatin with its lipid-lowering effects...
May 23, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28540474/lipid-levels-and-risk-of-venous-thrombosis-results-from-the-mega-study
#18
Vânia M Morelli, Willem M Lijfering, Mettine H A Bos, Frits R Rosendaal, Suzanne C Cannegieter
The relationship between lipid levels and risk of venous thrombosis is not well established. We aimed to assess the association between several lipids and risk of venous thrombosis using data from a population-based case-control study, and to evaluate the underlying mechanism, considering confounding by common risk factors and mediation via hemostatic factors and C-reactive protein. From the Multiple Environmental and Genetic Assessment of risk factors for venous thrombosis (MEGA) study, 2234 patients with a first venous thrombosis and 2873 controls were included...
May 24, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28540395/management-of-atherosclerosis-risk-factors-for-patients-at-high-cardiovascular-risk-in-the-real-world-practice-a-multicentre-study
#19
Arintaya Phrommintikul, Rungroj Krittayaphong, Wanwarang Wongcharoen, Sukit Yamwong, Smonporn Boonyaratavej, Rapeephon Kunjara-Na-Ayudhya, Pyatat Tatsanavivat, Piyamitr Sritara
INTRODUCTION: Atherosclerotic cardiovascular disease is a global health burden. However, there are heterogeneities among countries or regions regarding the risk factors and clinical manifestations of atherosclerotic diseases as well as their management patterns. METHODS: We collected data from 25 centres in Thailand. Patients with documented coronary artery disease or cerebrovascular disease or peripheral arterial disease, or with at least three atherosclerosis risk factors were enrolled between April 2011 and March 2014...
May 25, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28540139/prevalence-of-high-risk-cardiovascular-patients-with-therapy-resistant-hypercholesterolemia
#20
Karel Kostev, Klaus G Parhofer, Franz-Werner Dippel
INTRODUCTION: Hypercholesterolemia is a causal risk factor for cardiovascular diseases, which is recommended to be treated at least in high-risk patients. Yet, currently there is a lack of epidemiological data on the number of high-risk patients in Germany who do not respond adequately to high-dose statin monotherapy or statin therapy in combination with other lipid-lowering agents. METHODS: Of a total of over 2.6 million patient records from general practitioners in the IMS Disease Analyzer database, all high-risk cardiovascular patients with hypercholesterolemia who did not reach target low-density lipoprotein-cholesterol (LDL-C) levels despite at least 12 months of maximum lipid-lowering therapy and optimal medication supply (medication possession rate≥80%) were selected over a defined period...
June 2017: Cardiovascular Endocrinology
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