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https://www.readbyqxmd.com/read/28423684/prognostic-clinicopathologic-factors-in-carcinoma-of-unknown-primary-origin-a-study-of-106-consecutive-cases
#1
Junjeong Choi, Ji Hae Nahm, Sang Kyum Kim
A heterogeneous group of cancers for which the site of origin remains occult after detailed investigations is defined as carcinomas of unknown primary origin (CUPs). Because patients with CUP have a dismal prognosis, we have analyzed CUPs to highlight the implication of clinicopathologic factors related with patient survival. A total of 106 consecutive cases of CUP were collected. A two-step strategy of immunohistochemistry to assess CUPs according NCCN Guidelines is used to separate carcinomatous tumors and subtype carcinomas...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422888/18f-fdg-pet-ct-for-detection-of-the-primary-tumor-in-adults-with-extracervical-metastases-from-cancer-of-unknown-primary-a-systematic-review-and-meta-analysis
#2
Synne Alexandra Burglin, Søren Hess, Poul Flemming Høilund-Carlsen, Oke Gerke
BACKGROUND: Cancer of unknown primary (CUP) is a heterogeneous group of cancers, so called when a biopsy from a patient reveals malignancy without giving a clue to where in the body the primary tumor is located. Whole-body 18-fluorine-fluorodeoxyglucose positron-emission-tomography/computed tomography (18F-FDG PET/CT) is widely used for diagnosis and staging of most cancers. We hypothesized that 18F-FDG PET/CT-especially if used early-is suitable for the detection of the primary tumor in patients with CUP...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28422885/cancer-of-unknown-primary-registered-procedures-compared-with-national-integrated-cancer-pathway-for-illuminating-external-validity
#3
Anne-Kirstine Dyrvig, Knud Bonnet Yderstræde, Oke Gerke, Peter Bjødstrup Jensen, Søren Hess, Poul Flemming Høilund-Carlsen, Anders Green
Cancer of unknown primary (CUP) ranges within top 10 cancers in both incidence and mortality. As primary identification is crucial to choosing treatment, guidelines on CUP emphasize the diagnostic strategy. Whether guidelines are complied with, or if they are indeed helpful, is however unclear. We compared procedures performed in suspected CUP patients with recommendations of national guidelines to assess external validity of guidelines.The Danish National Patient Registry (NPR) comprising population data was utilized to identify the suspected CUP patients during 2009 to 2010 and explore exposure to procedures and patient survival...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28422758/first-in-human-trial-of-multikinase-vegf-inhibitor-regorafenib-and-anti-egfr-antibody-cetuximab-in-advanced-cancer-patients
#4
Vivek Subbiah, Muhammad Rizwan Khawaja, David S Hong, Behrang Amini, Jiang Yungfang, Hui Liu, Adrienne Johnson, Alexa B Schrock, Siraj M Ali, James X Sun, David Fabrizio, Sarina Piha-Paul, Siqing Fu, Apostolia M Tsimberidou, Aung Naing, Filip Janku, Daniel D Karp, Michael Overman, Cathy Eng, Scott Kopetz, Funda Meric-Bernstam, Gerald S Falchook
BACKGROUND: The combination of multikinase VEGF inhibitor regorafenib and anti-EGFR antibody cetuximab overcomes intrinsic and acquired resistance in both EGFR-sensitive and EGFR-resistant preclinical models of colorectal cancer (CRC). METHODS: Utilizing a standard 3+3 design, a phase I study was designed to determine safety, maximum tolerated dose (MTD), and dose-limiting toxicities (DLTs) of the regorafenib plus cetuximab combination among patients with advanced cancer including CRC...
April 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28418897/treatment-for-retropharyngeal-metastatic-undifferentiated-squamous-cell-carcinoma-from-an-unknown-primary-site-results-of-a-prospective-study-with-irradiation-to-nasopharyngeal-mucosa-plus-bilateral-neck
#5
Chengrun Du, Hongmei Ying, Youwang Zhang, Yafang Huang, Ruiping Zhai, Chaosu Hu
Background and Objetive: To evaluate treatment outcomes for patients with retropharyngeal metastatic undifferentiated squamous cell carcinoma (SCC) from an unknown primary site. METHODS: From January 2005 to January 2015, patients who presented with enlarged retropharyngeal nodes underwent transoral sonography-guided fine-needle aspiration to confirm histology. Those with metastatic undifferentiated SCC with unknown primary tumors were treated with radical radiotherapy to nasopharyngeal mucosa plus bilateral neck...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413396/mammary-analogue-secretory-carcinoma-presenting-as-a-cervical-lymph-node-metastasis-of-unknown-primary-site-a-case-report
#6
Kensuke Suzuki, Masao Yagi, Akira Kanda, Yoshiki Kobayashi, Masaya Konishi, Chika Miyasaka, Takashi Tashiro, Hiroshi Iwai
BACKGROUND: Mammary analogue secretory carcinoma (MASC) is a pathological entity arising in the salivary glands first described by Skalova et al. [Am J Surg Pathol 2010;34: 599-608]. Here, we report the first case of MASC presenting as a cervical lymph node metastasis of unknown primary site together with a brief review of the literature. CASE REPORT: We present a 74-year-old male with a painless lump in his left neck. Based on the fine-needle aspiration cytological findings, a possible malignant tumor was suspected...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28391557/cutaneous-basal-cell-carcinoma-with-distant-metastasis-to-thorax-and-bone-a-clinicopathological-and-immunohistochemical-study-of-15-cases
#7
Annikka Weissferdt, Neda Kalhor, Cesar A Moran
Basal cell carcinoma (BCC) is the most common cutaneous malignancy and is characterized by a high cure rate after local excision. Metastatic BCC (mBCC) is an exceedingly rare event, associated with poor prognosis. We report clinicopathological and immunohistochemical features of 15 mBCC metastatic to the thorax and bone. The patients were 14 males and one female with a mean age at diagnosis of cutaneous BCC of 53 years and at metastasis of 64 years. Primary BCC were primarily located in the head and neck or torso and microscopically included five nodular, three basosquamous, three mixed, and one each of superficial, infiltrative, micronodular, and morpheaform types...
April 8, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28390039/incidental-extra-cardiac-findings-on-13-n-ammonia-myocardial-perfusion-pet-ct
#8
H Kan, F M van der Zant, M Wondergem, R J J Knol
BACKGROUND: The objective of this study was to describe the prevalence of incidental extra-cardiac findings (IECFs) on myocardial perfusion PET/CTs and the prevalence of potentially clinically relevant and clinically irrelevant IECFs, as well as detection rate of previously unknown malignancies. METHODS AND RESULTS: From September 2013 until February 2016, a total of 1397 consecutive patients referred for the evaluation of possible ischemia by (13)NH3 PET/CT were prospectively included in a database...
April 7, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28383853/-carcinoma-of-unknown-primary-a-not-so-rare-entity
#9
REVIEW
E Gonne, J Collignon, G Jerusalem, C Gennigens
Carcinomas of unknown primary (CUP) form a whole group of heterogeneous neoplasias. CUP are defined as metastatic epithelial tumors in which the initial work up has failed to detect the primary site. Their frequency is 3-5 % of the adult solid neoplasias. The prognosis is poor with a life expectancy of a few months (inferior to 1 year). The treatment depends on the histology and, particularly, on the metastatic localiza¬tion. Surgery with or without radiotherapy is the preferred treatment option for isolated lesions...
October 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28379430/enhancing-identification-of-cancer-types-via-lowly-expressed-micrornas
#10
Roni Rasnic, Nathan Linial, Michal Linial
The primary function of microRNAs (miRNAs) is to maintain cell homeostasis. In cancerous tissues miRNAs' expression undergo drastic alterations. In this study, we use miRNA expression profiles from The Cancer Genome Atlas of 24 cancer types and 3 healthy tissues, collected from >8500 samples. We seek to classify the cancer's origin and tissue identification using the expression from 1046 reported miRNAs. Despite an apparent uniform appearance of miRNAs among cancerous samples, we recover indispensable information from lowly expressed miRNAs regarding the cancer/tissue types...
April 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28370570/unknown-primary-head-and-neck-squamous-cell-carcinoma-in-the-era-of-fluorodeoxyglucose-positron-emission-tomography-ct-and-intensity-modulated-radiotherapy
#11
Mischa de Ridder, Martin Klop, Olga Hamming-Vrieze, JanPaul de Boer, Bas Jasperse, Laura Smit, Wouter Vogel, Michiel van den Brekel, Abrahim Al-Mamgani
BACKGROUND: The diagnosis and treatment of head and neck carcinoma of unknown primary (CUP) have changed with the introduction of fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT and intensity-modulated radiotherapy (IMRT), with potential implications for outcome. METHODS: We conducted a retrospective analysis of 80 patients with head and neck CUP who were PET-staged and treated with curative intention using IMRT between 2006 and 2016 in the Netherlands Cancer Institute...
March 28, 2017: Head & Neck
https://www.readbyqxmd.com/read/28368513/power-and-limits-of-modern-cancer-diagnostics-cancer-of-unknown-primary
#12
K Hemminki, H Liu, A Hemminki, J Sundquist
No abstract text is available yet for this article.
March 27, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28361863/trichilemmal-cystis-in-metastatic-melanoma-a-case-report
#13
I Savarese, M Grazzini, A Gori, A D'Errico, L Doni, F Scarfì, P Covarelli, F Di Costanzo, V De Giorgi
The malignant melanoma is a neoplasm associated with a wide variety of cutaneous paraneoplastic syndromes, as dermatomyositis, systemic sclerosis, paraneoplastic pemphigus. We describe a case of four multiple trichilemmal cystis arising on frontal region in the same patient with brain metastasis and unknown primary melanoma and discuss their relationship.
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28343447/the-undifferentiated-carcinoma-that-became-a-melanoma-re-biopsy-of-a-cancer-of-an-unknown-primary-site-a-case-report
#14
Oluf Dimitri Røe, Sissel Gyrid Freim Wahl
BACKGROUND: Cancer of unknown primary site is still a demanding condition as it is per definition metastatic, with heterogeneous biological behavior, and it is often resistant to therapy. Cancer of unknown primary site accounts for approximately 1 to 5 % of all cancers, but is currently among the top six causes of cancer deaths in Western countries. To correctly identify the biological origin of the tumor, a large spectrum of differential diagnoses must be considered and scrutinized. At progression, re-biopsy might be necessary to reveal the true origin of the tumor or actionable targets...
March 27, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28342482/treatment-outcomes-in-veterans-with-hpv-positive-head-and-neck-cancer
#15
Aaron J Feinstein, Sophie G Shay, Elena Chang, Michael S Lewis, Marilene B Wang
OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC) caused by the human papilloma virus (HPV) has an improved prognosis relative to HPV-negative tumors. Patients with HPV-positive disease may benefit from different treatment modalities in order to optimize survival and quality of life. We sought to investigate HPV-positive HNSCC within the military veteran population, and analyze the role of treatment modality in outcomes of patients with HPV-positive and HPV-negative tumors. METHODS: Patients diagnosed with HNSCC between January 1, 2010 and December 31, 2014 at one regional veterans health center were retrospectively examined...
March 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28338116/how-to-diagnose-and-treat-a-cancer-of-unknown-primary-site
#16
REVIEW
Ciprian Tomuleasa, Florin Zaharie, Mihai-Stefan Muresan, Laura Pop, Zsolt Fekete, Delia Dima, Ioana Frinc, Adrian Trifa, Cristian Berce, Ancuta Jurj, Ioana Berindan-Neagoe, Mihnea Zdrenghea
Almost one in every three patients with advanced tumors have distant metastasis at the time of clinical diagnosis. In most cases, the primary tumor site is identified immediately, within a few days. But for some patients, the primary lesion cannot be found after the initial clinical assessment. These cases are called cancers of unknown primary origin (CUPs), a clinical diagnosis very difficult to manage by physicians due to the absence of a standard-of-care for the initial therapeutic regimen, as well as due to the impossibility to include these cases in randomized clinical trials...
March 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28335889/human-papillomavirus-as-prognostic-marker-with-rising-prevalence-in-neck-squamous-cell-carcinoma-of-unknown-primary-a-retrospective-multicentre-study
#17
Lea Schroeder, Paolo Boscolo-Rizzo, Elisa Dal Cin, Salvatore Romeo, Lorena Baboci, Gerhard Dyckhoff, Jochen Hess, Carlota Lucena-Porcel, Anne Byl, Nikolaus Becker, Laia Alemany, Xavier Castellsagué, Miquel Quer, Xavier León, Manuel Wiesenfarth, Michael Pawlita, Dana Holzinger
Patients with neck squamous cell carcinomas of unknown primary tumour (NSCCUP) present with lymph node metastasis without evidence for a primary tumour. Most patients undergo an aggressive multimodal treatment, which induces severe, potentially unnecessary toxicity. Primary tumours of NSCCUP can be hidden in the oropharynx. Human papillomavirus (HPV) is causally involved in a subgroup of oropharyngeal squamous cell carcinomas (OPSCC) associated with early lymph node metastasis and good prognosis. Detection of markers for HPV transformation in NSCCUP could allow focussing on the oropharynx in primary tumour search and could be of value for choice and extent of treatment...
March 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28323730/transesophageal-bronchoscopic-ultrasound-guided-fine-needle-aspiration-for-metastatic-vertebral-body-lesion
#18
Masahide Oki, Hideo Saka, Shu Ichihara, Suzuko Moritani
Malignant neoplasms frequently cause vertebral metastases. Traditionally, either image-guided percutaneous biopsy or open biopsy has been performed for sampling specimens for the definitive diagnosis. We herein report a case with suspected multiple metastases but unknown primary, who underwent endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal lymph nodes with negative results by rapid onsite cytologic evaluation, followed by the transesophageal approach with the ultrasound bronchoscope for the vertebral body lesion at the same setting that provided a definitive diagnosis of metastatic hepatocellular carcinoma...
April 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28322096/cdx2-immunostaining-in-primary-and-metastatic-germ-cell-tumours-of-the-testis
#19
Fatma Oz Atalay, Berna Aytac Vuruskan, Hakan Vuruskan
Objective To evaluate the immunohistochemical staining pattern of caudal type homeobox 2 (CDX2) protein in germ cell tumours (GCTs) of the testis. Methods This study reassessed archival tissue samples collected from patients diagnosed with primary and metastatic testicular GCTs for CDX2 immunoreactivity using standard immunohistochemical techniques. Positive nuclear immunostaining was evaluated with regard to both the staining intensity and the extent of the staining. Results Tissue sections from primary and metastatic testicular GCTs ( n = 104), germ cell neoplasia in situ (GCNis) ( n = 5) and benign testicles ( n = 15) were analysed...
December 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/28314959/cancer-of-unknown-primary-cup-of-the-head-and-neck-retrospective-analysis-of-81-patients
#20
Basel Al Kadah, Giorgos Papaspyrou, Maximilian Linxweiler, Bernhard Schick, Christian Rübe, Benjamin Simeon Büchler, Marcus Niewald
The treatment of patients with cervical lymph node metastases without detectable primary tumor remains an important challenge, until today, no standard therapy is available. The present study investigated the multimodal treatment of patients with head and neck CUP syndrome (HNCUP) and their follow-up retrospectively. 81 patients with cervical lymph node metastases without a primary tumor were treated at the Departments of Otorhinolaryngology as well as Radiotherapy and Radiation Oncology at the University of Saarland in Homburg, Germany in the period between 1991 and 2013...
March 17, 2017: European Archives of Oto-rhino-laryngology
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