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https://www.readbyqxmd.com/read/28208863/fine-needle-aspiration-cytology-of-papulonodular-lesions-of-skin-a-study-of-50-cases
#1
Sapna Patel, Asha Mahadevappa, Gubbanna Vimalambike Manjunath
INTRODUCTION: Skin is one of the frequent site of disease in human body. Fine Needle Aspiration Cytology (FNAC) is a safe diagnostic method in these cases. FNAC has some limitation, particularly related to representativity of samples, exact typing of skin adnexal tumours and classifying the nature of metastatic cutaneous nodules. Thus, FNAC alone may not give a confirmative diagnosis regarding few skin lesions. Hence, histopathological study has been the standard technique for the diagnosis of skin lesions...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28206871/swallowing-therapy-and-progressive-resistance-training-in-head-and-neck-cancer-patients-undergoing-radiotherapy-treatment-randomized-control-trial-protocol-and-preliminary-data
#2
Sara F Hajdú, Irene Wessel, Christoffer Johansen, Claus A Kristensen, Zahra T Kadkhoda, Christina C Plaschke, Susanne O Dalton
BACKGROUND: Head and neck cancer (HNC) patients are often challenged by treatment induced dysphagia and trismus. Traditionally, rehabilitation is initiated when loss of function has already occurred. There is increasing evidence that it is of benefit to patients to initiate an early rehabilitation process before and during treatment. HNC patients have a unique set of functional challenges such as pre- and post-treatment dysphagia, pain and weight loss. The aim of the trial is to investigate the effects of swallowing and mouth-opening exercises combined with progressive resistance training (PRT) during radiotherapy...
February 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28198461/risk-of-other-cancers-in-families-with-melanoma-novel-familial-links
#3
Christoph Frank, Jan Sundquist, Akseli Hemminki, Kari Hemminki
A family history of cutaneous melanoma ('melanoma') is a well-established risk factor for melanoma. However, less is known about the possible familial associations of melanoma with other discordant cancers. A risk for discordant cancer may provide useful information about shared genetic and environmental risk factors and it may be relevant background data in clinical genetic counseling. Using the Swedish Family-Cancer Database, we assessed the relative risk (RR) for any cancer in families with increasing numbers of first-degree relatives diagnosed with melanoma, including multiple melanoma, and in reverse order RR for melanoma in families of multiple discordant cancers...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196200/assessment-of-surgical-learning-curves-in-transoral-robotic-surgery-for-squamous-cell-carcinoma-of-the-oropharynx
#4
William G Albergotti, William E Gooding, Mark W Kubik, Mathew Geltzeiler, Seungwon Kim, Umamaheswar Duvvuri, Robert L Ferris
Importance: Transoral robotic surgery (TORS) is increasingly employed as a treatment option for squamous cell carcinoma of the oropharynx (OPSCC). Measures of surgical learning curves are needed particularly as clinical trials using this technology continue to evolve. Objective: To assess learning curves for the oncologic TORS surgeon and to identify the number of cases needed to identify the learning phase. Design, Setting, and Participants: A retrospective review of all patients who underwent TORS for OPSCC at the University of Pittsburgh Medical Center between March 2010 and March 2016...
February 9, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28193254/developing-a-new-diagnostic-algorithm-for-human-papilloma-virus-associated-oropharyngeal-carcinoma-an-investigation-of-hpv-dna-assays
#5
Natasha Cohen, Michael Gupta, Lilian Doerwald-Munoz, Dan Jang, James Edward Massey Young, Stuart Archibald, Bernard Jackson, Jenny Lee, Max Chernesky
BACKGROUND: Human papilloma virus (HPV) has been implicated in the development of a large proportion of oropharyngeal squamous cell carcinoma (OPSCC). Current techniques used to diagnose HPV etiology require histopathologic analysis. We aim to investigate the diagnostic accuracy of a new application non-histopathologic diagnostic tests to help assist diagnosis of HPV-related oropharyngeal tumors. METHODS: Patients with OPSCC with nodal metastasis were consecutively recruited from a multidisciplinary cancer clinic...
February 13, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28180954/magnetic-resonance-imaging-appearance-of-soft-tissue-metastases-our-experience-at-an-orthopedic-oncology-center
#6
Jennifer Sammon, Abhishek Jain, Robert Bleakney, Rakesh Mohankumar
OBJECTIVE: To assess the prevalence and magnetic resonance imaging appearance of metastasis presenting as a soft-tissue mass. MATERIALS AND METHODS: A retrospective chart review was performed on 51 patients who presented to an orthopedic oncology center with soft-tissue masses, with a histology-proven diagnosis of soft-tissue metastasis, over a 14-year period. Their magnetic resonance imaging, primary origin, and follow-up have been assessed. RESULTS: Soft-tissue metastasis was identified in patients ranging from 18 to 85 years old...
February 8, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28180041/update-on-surgical-outcomes-of-lateral-temporal-bone-resection-for-ear-and-temporal-bone-malignancies
#7
Sumi Sinha, Matthew M Dedmon, Matthew R Naunheim, Jennifer C Fuller, Stacey T Gray, Derrick T Lin
Objectives Review outcomes of lateral temporal bone resections for ear and temporal bone malignancy. Design, Setting, and Participants Retrospective review of all lateral temporal bone resections performed from 2008 to 2015 at a single tertiary care center. Main Outcome Measures Patient demographics, perioperative variables, overall survival, disease-free survival (DFS), and comparison of Kaplan-Meier curves. Results Overall, 56 patients were identified with a mean follow-up period of 2.3 ± 1.8 years...
February 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28179315/validation-of-human-papillomavirus-as-a-favourable-prognostic-marker-and-analysis-of-cd8-tumour-infiltrating-lymphocytes-and-other-biomarkers-in-cancer-of-unknown-primary-in-the-head-and-neck-region
#8
Lars Sivars, David Landin, Nathalie Grün, Andrea Vlastos, Linda Marklund, Sushma Nordemar, Torbjörn Ramqvist, Eva Munck-Wikland, Anders Näsman, Tina Dalianis
BACKGROUND: Human papillomavirus (HPV) is a favourable prognostic factor in oropharyngeal cancer. Moreover, we and others reported that HPV-positive cancer of unknown primary in the head and neck region (HNCUP) has better outcome than HPV-negative HNCUP. However, not all studies concord. Here, our previous finding was investigated in a new cohort and additional biomarkers were analyzed. MATERIALS AND METHODS: A total of 19 HNCUPs diagnosed 2008-2013 were analyzed for HPV DNA by polymerase chain reaction assay (PCR) and p16 by immunohistochemistry (IHC)...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28166262/l1-retrotransposon-expression-in-circulating-tumor-cells
#9
Ioannis Papasotiriou, Katerina Pantopikou, Panagiotis Apostolou
Long interspersed nuclear element 1 (LINE-1 or L1) belongs to the non-long terminal repeat (non-LTR) retrotransposon family, which has been implicated in carcinogenesis and disease progression. Circulating tumor cells (CTCs) are also known to be involved in cancer progression. The present study aimed to compare the L1 expression between circulating tumor cells and non-cancerous samples. Blood samples were collected from 10 healthy individuals and 22 patients with different types of cancer. The whole blood cells were isolated using enrichment protocols and the DNA and RNA were extracted...
2017: PloS One
https://www.readbyqxmd.com/read/28156464/short-course-radiation-for-palliation-of-squamous-cell-carcinoma-of-an-unknown-primary-of-the-head-and-neck
#10
William M Mendenhall
: 62 Background: The purpose of this study was to examine the treatment patterns used for palliative radiotherapy for squamous cell carcinoma of an unknown primary of the head and neck and to compare the acute toxicity and tumor response for these patients for the most common dose-fractionation regimens. METHODS: Patients with biopsy-proven squamous cell carcinoma of an unknown primary with cervical lymphadenopathy were included who were treated with radiation therapy with palliative intent at a single institution between 1966 and 2015 (N = 45)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28154019/mib1-index-stratified-assessment-of-dual-tracer-pet-ct-with-68ga-dotatate-and-18f-fdg-and-multimodality-anatomical-imaging-in-metastatic-net-of-unknown-primary-cup-net-scheduled-for-prrt
#11
Nikita Sampathirao, Sandip Basu
AIM: Comparative assessment of dual tracer PET/CT ((68)Ga-DOTATATE and (18)F-FDG) and multimodality anatomical imaging in studying CUP-NETs scheduled for PRRT for: (i) divergence of tracer uptake on dual tracer PET/CT, (ii) detection of primary and (iii) overall lesion detection vis-a-vis tumor proliferation index (Mib1/Ki-67). MATERIALS AND METHODS: Fifty-one patients of CUP-NETs (M:F=25:26, age:22-74 years), histopathologically proven and thoroughly investigated with conventional imaging modalities (USG, CT/ceCT, MRI and EUS, wherever applicable), were retrospective analyzed...
February 2, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28153957/localization-of-unknown-primary-site-with-68ga-dotatoc-pet-ct-in-patients-with-metastatic-neuroendocrine-tumor
#12
Yusuf Menda, Thomas M O'Dorisio, James Howe, Michael King Schultz, Joseph Dillon, David Dick, Leonard G Watkins, Timothy Ginader, David L Bushnell, John Sunderland, Gideon Kd Zamba, Michael M Graham, M Sue O'Dorisio
: Localization of the site of the unknown primary tumor is critical for surgical treatment of patients presenting with neuroendocrine tumor (NET) with metastases. METHODS: A single-center prospective study was performed to evaluate the safety and efficacy of (68)Ga-DOTATOC PET/CT in patients with diagnosis of or suspected NET. A subgroup of patients with metastases and unknown primary after initial work-up was analyzed. The ((68)Ga)Ga-DOTATOC PET/CT was considered true positive if the positive primary site was confirmed by histology or follow-up imaging...
February 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28144684/combined-p16-and-p53-expression-in-cervical-cancer-of-unknown-primary-and-other-prognostic-parameters-a-single-center-analysis
#13
Müjdat Yildirim, Jens Müller von der Grün, Ria Winkelmann, Emmanouil Fokas, Franz Rödel, Hanns Ackermann, Claus Rödel, Panagiotis Balermpas
BACKGROUND AND PURPOSE: Cervical cancer of unknown primary (CUP) represents an uncommon and heterogeneous subentity of head and neck cancer. However, both optimal diagnostics and therapy remain unclear. An improved understanding of the underlying pathology is essential to enable future tailored therapies and optimized outcomes. MATERIALS AND METHODS: We retrospectively analyzed 53 patients with head and neck CUP and 48 available cervical lymph node specimens. All patients have received radiotherapy between 2007 and 2015...
January 31, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28143449/cancers-of-unknown-primary-diagnosed-during-hospitalization-a-population-based-study
#14
William Jones, Gwen Allardice, Iona Scott, Karin Oien, David Brewster, David S Morrison
BACKGROUND: Cancers of Unknown Primary (CUP) are the 3-4(th) most common causes of cancer death and recent clinical guidelines recommend that patients should be directed to a team dedicated to their care. Our aim was to inform the care of patients diagnosed with CUP during hospital admission. METHODS: Descriptive study using hospital admissions (Scottish Morbidity Record 01) linked to cancer registrations (ICD-10 C77-80) and death records from 1998 to 2011 in West of Scotland, UK (population 2...
January 31, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28130620/extranodal-spread-is-associated-with-recurrence-and-poor-survival-in-stage-iii-cutaneous-melanoma-patients
#15
Thomas R Crookes, Richard A Scolyer, Serigne Lo, Martin Drummond, Andrew J Spillane
BACKGROUND: Inconsistent data suggests extranodal spread (ENS) is an adverse prognostic factor in Stage III melanoma patients but it remains contentious. By rigorously matching cohorts, this study sought to clarify associations with recurrence and survival. METHODS: Melanoma patients with lymph node metastases (AJCC Stage III), with or without ENS, sub-classified on the basis of known (MKP) or unknown primary (MUP), were identified from a single institution prospective database...
January 27, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28105346/human-papillomavirus-is-a-favourable-prognostic-factor-in-cancer-of-unknown-primary-in-the-head-and-neck-region-and-in-hypopharyngeal-cancer
#16
Lars Sivars, Cinzia Bersani, Nathalie Grün, Torbjörn Ramqvist, Eva Munck-Wikland, Christian Von Buchwald, Tina Dalianis
Human papillomavirus (HPV), in addition to smoking and alcohol, is a cause of oropharyngeal squamous cell carcinoma (OPSCC), particularly of the tonsils and base of the tongue (TSCC and BOTSCC, respectively). Moreover, HPV-positive TSCC and BOTSCC are associated with a better outcome compared with their HPV-negative counterparts (80 vs. 40% 3-year disease-free survival rate, respectively) and their incidence has increased in several countries. Recently, accumulating evidence of HPV in a considerable proportion of cancers of unknown primary (CUP) in the head and neck region and in a small proportion of hypopharyngeal SCCs has been reported...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28101916/perceptions-of-cancer-of-unknown-primary-site-a-national-survey-of-australian-medical-oncologists
#17
Christos S Karapetis, Lisa Guccione, Martin Hn Tattersall, Helen Gooden, Claire M Vajdic, Sylvie Lambert, Monica Robotin, Linda Mileshkin, Penelope Schofield
INTRODUCTION: Despite being the 6(th) cause of cancer death in Australia, cancer of unknown primary (CUP) site remains poorly understood. AIMS: To describe practices relating to the diagnosis, investigation, classification, communication and management of CUP amongst medical oncologists. METHODS: We invited all members of the Medical Oncology Group of Australia to participate in a national, anonymous online survey about CUP. The survey collected data regarding diagnosis acceptance, diagnostic tests, treatment protocols and communication practices around the diagnosis of CUP...
January 19, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28088602/aggressive-surgical-approach-to-the-management-of-neuroendocrine-tumors-a-report-of-1-000-surgical-cytoreductions-by%C3%A2-a%C3%A2-single%C3%A2-institution
#18
Eugene A Woltering, Brianne A Voros, David T Beyer, Yi-Zarn Wang, Ramcharan Thiagarajan, Pamela Ryan, Anne Wright, Robert A Ramirez, M Jennifer Ricks, J Philip Boudreaux
BACKGROUND: Neuroendocrine tumors (NETs) are rare neoplasms. Our group has treated more than 2,000 NET patients and has performed more than 1,000 surgical cytoreductive procedures. STUDY DESIGN: Records of 834 NET patients who underwent surgical cytoreduction at our institution were reviewed. Demographic information, intraoperative findings, extent of disease, complications, and survival rates were calculated. RESULTS: Eight hundred patients underwent 1,001 cytoreductive operations...
January 11, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28073212/ultrasound-features-of-a-metastatic-seminal-vesicle-melanoma-a-case-report
#19
Andrea Fabiani, Emanuele Principi, Alessandra Filosa, Fabrizio Fioretti, Valentina Maurelli, Lucilla Servi, Gabriele Mammana
In this report we describe what we consider to be the second case of seminal vescicle (SV) metastasis from an unknown primary melanoma. only presenting symptom was a palpable firm nodule of the right prostate base on digital rectal examination (DRE). The diagnosis, after prostatic transrectal ultrasound examination (TRUS), was performed by ultrasound guided biopsy. We underline that prostatic TRUS evaluation is mandatory in case of abnormal digital rectal examination. Seminal vesicle must be always evaluated...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28052277/unknown-primary-melanoma-worldwide-survey-on-clinical-management
#20
Simone Ribero, Riccardo Pampena, Veronique Bataille, Elvira Moscarella, Luc Thomas, Pietro Quaglino, Concetta Potenza, Alexander C J Van Akkooi, Alessandro Testori, Paul Nathan, Susana Puig, Iris Zalaudek, Giuseppe Argenziano, Caterina Longo
BACKGROUND: How to deal with melanoma of unknown primary (MUP) origin is a debated topic in the literature. OBJECTIVE: We performed a worldwide survey to inquire what clinical and investigational workup is performed as well as the physicians' perception of this disease. METHODS: A questionnaire was sent via mail to clinicians involved in melanoma care from December 2015 to April 2016 using the International Dermoscopy Society website. RESULTS: 119 physicians from 47 different countries answered the questionnaire...
January 5, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
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