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https://www.readbyqxmd.com/read/29451701/phase-1b-study-of-pasireotide-everolimus-and-selective-internal-radioembolization-therapy-for-unresectable-neuroendocrine-tumors-with-hepatic-metastases
#1
Hyun S Kim, Walid L Shaib, Chao Zhang, Ganji Purnachandra Nagaraju, Christina Wu, Olatunji B Alese, Zhengjia Chen, Edith Brutcher, Meredith Renfroe, Bassel F El-Rayes
BACKGROUND: Neuroendocrine tumors (NETs) metastasize to the liver. Everolimus and selective internal radioembolization (SIRT) are approved treatments. Pasireotide is a somatostatin analogue with an affinity for somatostatin receptors 1, 2, 3, and 5. Everolimus and pasireotide may potentiate SIRT radiosensitization and inhibit rebound angiogenesis. This study evaluated the safety of pasireotide, everolimus, and SIRT. METHODS: This 3 + 3 phase 1 trial evaluated 3 dose levels of everolimus (2...
February 16, 2018: Cancer
https://www.readbyqxmd.com/read/29443782/putative-lung-adenocarcinoma-with-epidermal-growth-factor-receptor-mutation-presenting-as-carcinoma-of-unknown-primary-site-a-case-report
#2
Masahiro Yamasaki, Kunihiko Funaishi, Naomi Saito, Ayaka Sakano, Megumu Fujihara, Wakako Daido, Sayaka Ishiyama, Naoko Deguchi, Masaya Taniwaki, Nobuyuki Ohashi, Noboru Hattori
RATIONALE: Only a few cases of putative lung adenocarcinoma presenting as carcinoma of unknown primary site (CUP) with epidermal growth factor receptor (EGFR) mutation have been reported, and the efficacy of EGFR-tyrosine kinase inhibitors (TKIs) for these cases is unclear. PATIENT CONCERNS AND DIAGNOSES: A 67-year-old man complained of paresis of the right lower extremity, dysarthria, and memory disturbance. Computed tomography and magnetic resonance imaging showed multiple brain tumors with brain edema and swelling of the left supraclavicular, mediastinal, and upper abdominal lymph nodes...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29433539/prognostic-impact-of-presumed-breast-or-ovarian-cancer-among-patients-with-unfavorable-subset-cancer-of-unknown-primary-site
#3
Makoto Kodaira, Kan Yonemori, Tatsunori Shimoi, Akihiko Yoshida, Masayuki Yoshida, Atsuko Kitano, Akihiko Shimomura, Mayu Yunokawa, Chikako Shimizu, Yuichi Takiguchi, Yasuhiro Fujiwara, Kenji Tamura
BACKGROUND: The clinical utility and prognostic impact of presumed primary breast or ovarian cancer among patients with an unfavorable subset of cancer of unknown primary site (CUP) remains unclear. We aimed to evaluate the clinical relevance of the presumed primary site of CUP and the clinical outcome of site-specific therapy based on such presumptions. METHODS: Patients referred to our center who were diagnosed with unfavorable-subset CUP and treated between April 2007 and March 2015 were enrolled in this study...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29430119/a-rare-case-of-synchronous-papillary-microcarcinoma-and-metastatic-neuroendocrine-tumor-of-unknown-primary
#4
Shambo Guha Roy, Sarthak Tripathy, Girish Kumar Parida, Shipra Agarwal, Chandrasekhar Bal
Thyroid papillary microcarcinomas (PMCs) usually follow a very benign clinical course and are rarely metastatic. Any case of PMC presenting with distant metastases without any rising thyroglobulin level should be suspected to have any other primary apart from the thyroid and a meticulous clinical and diagnostic approach should be considered to identify the second primary. We hereby present a case of 52-year-old female treated as PMC with metastatic liver lesion, which was initially thought to be of thyroidal origin...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29419616/effectiveness-of-primary-surgery-versus-primary-radiotherapy-on-unknown-primary-head-and-neck-squamous-cell-carcinoma-a-systematic-review-protocol
#5
Nuwan Dharmawardana, Jared M Campbell, A Simon Carney, Samuel Boase
The review question is: what is the effectiveness of primary surgery versus primary radiotherapy on disease-free survival and quality of life in adults with an unknown primary, head and neck squamous cell carcinoma?
February 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29394825/-a-case-of-bladder-metastasis-from-breast-cancer
#6
Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Tamami Morisaki, Satoru Noda, Tsutomu Takashima, Naoyoshi Onoda, Kosei Hirakawa, Masaichi Ohira
A 64-year-old woman visited hospital with a chief complaint of a nodule at the left neck skin. Skin biopsy revealed adenocarcinoma, and the diagnosis was skin metastasis of unknown primary origin. Positron emission tomography and computed tomography showed multiple bone and lymph node metastasis, left breast tumor, bladder tumor, and hydronephrosis. A needle biopsy of breast revealed invasive ductal carcinoma, and transurethral biopsy of bladder revealed adenocarcinoma. The findings were similar to those for the breast and the expression pattern of estrogen-receptor was the same...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29392723/role-of-narrow-band-imaging-in-detection-of-head-and-neck-unknown-primary-squamous-cell-carcinoma
#7
Marta Filauro, Alberto Paderno, Pietro Perotti, Filippo Marchi, Sabrina Garofolo, Giorgio Peretti, Cesare Piazza
OBJECTIVES/HYPOTHESIS: There is no general consensus on what kind of examination to include in an optimal detection strategy for head and neck squamous cell carcinomas of unknown primary (SCCUPs). This study investigates the role of narrow-band imaging (NBI) in their identification. STUDY DESIGN: Case series. METHODS: Twenty-nine consecutive patients affected by SCCUPs were referred at two academic institutions. Selection criteria were: 1) lymph node cytology positive for squamous cell carcinoma (SCC); 2) no evidence of any primary at white light (WL); 3) negative contrast-enhanced computed tomography (CT) and/or magnetic resonance imaging, and positron emission tomography-CT; and 4) no contraindication to general anesthesia...
February 2, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29362629/primary-solitary-melanoma-of-the-lymphatic-nodes-or-a-single-metastasis-of-unknown-melanoma-do-we-need-a-new-staging-system
#8
Georgi Tchernev, Anastasiya Chokoeva, Lyubomira Victor Popova
BACKGROUND: Malignant melanoma is a disease which has a cutaneous origin in 90% of the patients, but in rare cases, it could be discovered as secondary deposits with unknown primary site. Metastatic Malignant Melanoma occurs without a primary site in about 3% of all melanoma patients, and it could be divided into two main groups: metastatic lymph nodes' involvement or non-lymph nodes disease. The lack of unified classification and staging system, provided by AJCC (2009), as well as the lack for curtain diagnostic and therapeutic protocol, prompt us to raise the question what is the right way to precede in cases of metastasis of the lymph nodes, without evidence of a primary tumour? CASE REPORT: We report a case of 67-years- old woman who presented in the dermatology clinic after a surgical removal of an enlarged lymph node in her left femoral area, verified histologically as a metastasis of melanoma...
December 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29362125/head-and-neck-squamous-cell-carcinoma-of-unknown-primary-outcomes-of-a-pre-defined-institutional-treatment-policy-in-a-region-with-a-high-prevalence-of-skin-cancer
#9
Michael Huo, Benedict Panizza, Anne Bernard, Sandro V Porceddu
OBJECTIVES: To determine the rate of subsequent primary site failure in patients with head and neck squamous cell carcinoma of unknown primary (UKP HNSCC) in a region with a high prevalence of cutaneous squamous cell carcinoma, according to a pre-determined institutional policy. Secondary aims included regional and distant control, and overall survival. MATERIAL AND METHODS: Patients presenting between April 2005 and June 2016 to the Princess Alexandra Hospital Head and Neck Multidisciplinary Meeting with UKP HNSCC from either presumed mucosal or cutaneous sites treated with curative intent were eligible...
February 2018: Oral Oncology
https://www.readbyqxmd.com/read/29361629/-a-case-of-cervical-lymph-node-metastasis-from-an-unknown-primary-cancer-controlled-with-immunotherapy-chemotherapy-and-surgery
#10
Manabu Yamada, Kimio Uchiyama, Masatsugu Tashiro
We present a case of cervical lymph node metastasis from an unknown primary cancer that was controlled with immunotherapy, chemotherapy, and surgery. The patient, a 61-year-old man, was referred to our department for treatment of a lesion in the left cervical lateral area. At the initial visit, the mass was covered by reddened skin and was elastic, hard, and immobile on palpation. The presence of a malignant disease such as malignant lymphoma or lymphadenitis because of infection by tubercle bacillus or Epstein-Barr virus was suspected on the basis of the clinical and magnetic resonance imaging findings...
December 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29356738/rhabdomyosarcoma-revealed-by-a-breast-metastasis
#11
Marie Luporsi, Thibaut Cassou-Mounat, Henri-Marc Amiot, Valerie Laurence, Nina Jehanno
A 38-year-old woman was referred for staging of an alveolar rhabdomyosarcoma revealed by a breast metastasis with unknown primary. Whole-body F-FDG PET/CT localized the primary tumor as an asymptomatic soft tissue lesion of the right foot with a significant uptake. PET/CT detected hepatic and pancreatic metastases and also showed a multifocal bone marrow involvement, which was not detected by the contrast-enhanced CT. These results led to a significant change in treatment management as the patient received local radiotherapy of the primitive lesion and polychemotherapy...
January 19, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29352954/unexpected-findings-in-a-patient-with-cancer-of-unknown-primary-syndrome
#12
Christoph Lübbert, Babett Holler
No abstract text is available yet for this article.
January 17, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29338089/outcomes-of-patients-diagnosed-with-carcinoma-metastatic-to-the-neck-from-an-unknown-primary-source-and-treated-with-intensity-modulated-radiation-therapy
#13
Mona Kamal, Abdallah S R Mohamed, Clifton David Fuller, Erich M Sturgis, Faye M Johnson, William H Morrison, G Brandon Gunn, Katherine A Hutcheson, Jack Phan, Stefania Volpe, Sweet Ping Ng, Renata Ferrarotto, Steven J Frank, Heath D Skinner, David I Rosenthal, Adam S Garden
BACKGROUND: There are few published studies to guide the treatment of carcinoma metastatic to the neck from an unknown primary (CUP). In this regard, the objective of the current study was to share the authors' current experience treating patients with CUP using intensity-modulated radiation therapy (IMRT), which principally targeted both sides of the neck, the nasopharynx, and the oropharynx. METHODS: This was a retrospective study in which an institutional database search was conducted to identify patients with CUP who received IMRT...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29330244/primary-care-physicians-struggle-with-current-adult-pneumococcal-vaccine-recommendations
#14
Laura P Hurley, Mandy A Allison, Tamara Pilishvili, Sean T O'Leary, Lori A Crane, Michaela Brtnikova, Brenda L Beaty, Megan C Lindley, Carolyn B Bridges, Allison Kempe
INTRODUCTION: In 2012, the Advisory Committee on Immunization Practices recommended 13-valent pneumococcal conjugate vaccine (PCV13) in series with 23-valent pneumococcal polysaccharide vaccine (PPSV23) for at-risk adults ≥19; in 2014, it expanded this recommendation to adults ≥65. Primary care physicians' practice, knowledge, attitudes, and beliefs regarding these recommendations are unknown. METHODS: Primary care physicians throughout the U.S. were surveyed by E-mail and post from December 2015 to January 2016...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29310489/unknown-primary-squamous-cell-carcinoma-of-the-head-and-neck-retrospective-analysis-of-80-cases
#15
Masanobu Mizuta, Morimasa Kitamura, Ichiro Tateya, Hisanobu Tamaki, Shinzo Tanaka, Ryo Asato, Shogo Shinohara, Shinji Takebayashi, Toshiki Maetani, Yoshiharu Kitani, Yohei Kumabe, Tsuyoshi Kojima, Koji Ushiro, Kazuyuki Ichimaru, Keigo Honda, Koichiro Yamada, Koichi Omori
OBJECTIVES: The management of patients with cervical metastasis in head and neck cancer of unknown primary (HNCUP) remains controversial. This current multicenter retrospective study investigated the treatment outcomes of patients with HNCUP. METHODS: The study included patients who were treated curatively at 12 institutions in Japan from January 2006 to December 2015. RESULTS: Eighty patients with HNCUP were included. The median follow-up period was 34 months...
January 8, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29285946/implementation-of-a-metastatic-malignancy-of-unknown-primary-origin-service-led-by-a-palliative-physician
#16
David Brooks, Philippa Hughes, Clare Farrington, Peter A Bath, Mary McGregor, Wasim Ahmed, Bill Noble
BACKGROUND: Cancer of unknown primary is the fourth most common cause of cancer death in the United Kingdom. National guidance in 2010 recommended the establishment of a dedicated unknown primary team to facilitate targeted investigation and symptom control. A service development project was undertaken to identify those affected by malignancy of unknown origin and institute a pathway for coordinating their care led by a palliative physician. AIM: To describe the patient population and illness trajectory and to assess the effect of the new pathway on the clinical outcomes...
December 29, 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29277825/stereotactic-radiosurgery-alone-for-one-to-two-brain-metastases-from-cancer-of-unknown-primary
#17
Liesa Dziggel, Amira Bajrovic, Steven E Schild, Dirk Rades
BACKGROUND/AIM: The use of stereotactic radiosurgery (SRS) alone has become popular for treating patients with a limited number of brain metastases. In very few patients, the primary tumor leading to cerebral spread is unknown. This study investigated the role of SRS for this rare situation. PATIENTS AND METHODS: Eight patients with 1-2 brain metastases from cancer of unknown primary (CUP) received SRS alone (median dose 20 Gy). Five clinical factors were evaluated for association with local control of the irradiated lesions, freedom from new cerebral lesions and survival...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29275831/-advances-in-the-management-of-cervical-lymphadenopathies-of-unknown-primary-advances-in-diagnostic-imaging-and-surgical-modalities-and-new-international-staging-system
#18
REVIEW
Idriss Troussier, Guillaume Klausner, Sylvain Morinière, Eivind Blais, Jean-Christophe Faivre, Ambroise Champion, Lionnel Geoffrois, Carole Pflumio, Emmanuel Babin, Philippe Maingon, Juliette Thariat
INTRODUCTION: Cervical lymphadenopathies of unknown primary represent 3 % of head and neck cancers. Their diagnostic work up has largely changed in recent years. This review provides an update on diagnostic developments and their potential therapeutic impact. MATERIALS AND METHODS: This is a systematic review of the literature. RESULTS: In recent years, changes in epidemiology-based prognostic factors such as human papilloma virus (HPV) cancers, advances in imaging and minimally invasive surgery have been integrated in the management of cervical lymphadenopathies of unknown primary...
December 21, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29258812/evaluating-bevacizumab-in-combination-with-folfiri-after-the-failure-of-platinum-etoposide-regimen-in-patients-with-advanced-poorly-differentiated-neuroendocrine-carcinoma-the-prodige-41-bevanec-randomized-phase-ii-study
#19
Thomas Walter, David Malka, Olivia Hentic, Catherine Lombard-Bohas, Karine Le Malicot, Denis Smith, Aurélie Ferru, Eric Assenat, Guillaume Cadiot, Astrid Lievre, Jean-Emmanuel Kurtz, Laetitia Dahan, Olivier Dubreuil, Vincent Hautefeuille, Céline Lepere, Alice Gangloff, Farid Elhajbi, Romain Coriat, Guillaume Roquin, Nadia Bouarioua, Victoire Granger, Jean-Yves Scoazec, Côme Lepage
INTRODUCTION: Patients with gastroenteropancreatic (GEP), metastatic or locally advanced, non-resectable, grade 3 poorly-differentiated neuroendocrine carcinoma (NEC) are treated with cisplatin (or carboplatin)-etoposide in first-line palliative chemotherapy (CT1). However, nearly all patients will develop resistance and there is no standard second-line treatment. AIM: PRODIGE 41-BEVANEC is an academic randomized, phase II study designed to evaluate the efficacy of bevacizumab in combination with FOLFIRI after failure of CT1 in unknown primary NEC and GEP-NEC...
December 6, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29250663/immunohistochemical-diagnosis-of-krukenberg-tumors
#20
Melania Ioana Crăciun, Iacob Domşa
The diagnosis of Krukenberg tumors, as in other types of metastatic tumors of unknown primary origin, can often be a challenge for clinicians. In many cases, traditional diagnostic methods are insufficient, requiring immunohistochemistry analysis for identifying the origin of metastatic tumors. In our study, we examined a total of 34 female patients with Krukenberg tumors with different sites of the primary tumor: gastric (n=18), colorectal (n=6) or breast (n=7) and tumors with unknown origin (n=3). Cytokeratin (CK) 7 and CK20, carcinoembryonic antigen (CEA) and cancer antigen (CA) 125 were applied...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
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