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https://www.readbyqxmd.com/read/29045506/clinical-and-molecular-characterization-of-patients-with-cancers-of-unknown-primary-in-the-modern-era
#1
A M Varghese, A Arora, M Capanu, N Camacho, H H Won, A Zehir, J Gao, D Chakravarty, N Schultz, D S Klimstra, M Ladanyi, D M Hyman, D B Solit, M F Berger, L B Saltz
Background: On the basis of historical data, patients with cancers of unknown primary (CUP) are generally assumed to have a dismal prognosis with overall survival of less than one year. Treatment is typically cytotoxic chemotherapy guided by histologic features and the pattern of metastatic spread. The purpose of this study was to provide a clinical and pathologic description of patients with CUP in the modern era, to define the frequency of clinically actionable molecular alterations in this population, to determine how molecular testing can alter therapeutic decisions, and to investigate novel uses of next generation sequencing in the evaluation and treatment of patients with CUP...
September 26, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29037604/met-activation-and-physical-dynamics-of-the-metastatic-process-the-paradigm-of-cancers-of-unknown-primary-origin
#2
REVIEW
Giulia M Stella, Silvia Benvenuti, Alessandra Gentile, Paolo M Comoglio
The molecular and cellular mechanisms which drive metastatic spread are the topic of constant debate and scientific research due to the potential implications for cancer patients' prognosis. In addition to genetics and environmental factors, mechanics of single cells and physical interaction with the surrounding environment play relevant role in defining invasive phenotype. Reconstructing the physical properties of metastatic clones may help to clarify still open issues in disease progression as well as to lead to new diagnostic and therapeutic approaches...
September 21, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29033672/role-of-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-the-evaluation-of-head-and-neck-carcinoma
#3
REVIEW
Moheieldin M Abouzied, Ahmed Fathala, Abdulaziz Alsugair, Ahmad I Al Muhaideb, Mohammed H Al Qahtani
Fluorodeoxyglucose (FDG)-positron emission tomography-computed tomography (PET-CT) has been playing a pivotal role in tumor imaging for the past 20 years. Head and neck (HN) cancers are a good example that can illustrate such unique role of FDG imaging contributing to the patient's management. In this review article, we will describe the normal physiological distribution of FDG within HN structures focusing on its limitations and pitfalls. In addition, we will be also describing its role in the initial staging and restaging of the disease, particularly with regard to therapy response assessment...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29033443/signet-ring-cell-carcinoma-of-unknown-primary-origin-detected-incidentally-by-lymph-node-purification-for-thyroid-carcinoma
#4
Hideo Handa, Daisuke Gomi, Toshirou Fukushima, Takashi Kobayashi, Nodoka Sekiguchi, Akiyuki Sakamoto, Yoshiko Tsukahara, Hirohide Matsushita, Shigeru Sasaki, Keiko Mamiya, Tomonobu Koizumi, Takashi Ichiyama
A 63-year-old woman underwent thyroidectomy for papillary thyroid adenocarcinoma and cervical lymph node resection. Pathological analyses revealed the presence of signet cell carcinoma in a resected lymph node, which were apparently different from the pathological findings of thyroid carcinoma. No evidence of a primary tumor could be found elsewhere despite detailed examinations, including esophagogastroduodenoscopy, colonoscopy, capsule endoscopy, CT scan, and fluorodeoxyglucose-positron emission tomography...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29029767/pet-ct-and-pet-mri-in-head-and-neck-malignancy
#5
REVIEW
T A Szyszko, G J R Cook
Combined 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET)/computed tomography (CT) has an established role in the staging of difficult cases of head and neck (HN) squamous cell carcinoma (SCC), looking for an unknown primary, assessing response post-chemotherapy at 3-6 months, and differentiating relapse from treatment effects in patients suspected to have tumour recurrence. The PET NECK trial, comparing PET/CT surveillance versus neck dissection in advanced head and neck cancer showed survival was similar among patients who underwent PET/CT-guided surveillance and those who underwent planned neck dissection, but surveillance was more cost-effective...
October 10, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29025982/appropriate-use-criteria-for-somatostatin-receptor-pet-imaging-in-neuroendocrine-tumors
#6
Thomas A Hope, Emily Bergsland, Murat Fani Bozkurt, Michael M Graham, Anthony P Heaney, Ken Herrmann, James R Howe, Matthew H Kulke, Pamela L Kunz, Josh Mailman, Lawrence May, David C Metz, Corina Millo, Sue O'Dorisio, Diane L Reidy-Lagunes, Michael C Soulen, Jonathan R Strosberg
Somatostatin receptor positron emission tomography (SSTR-PET) is an imaging modality for patients with neuroendocrine tumors (NETs) that has demonstrated a significant improvement over conventional imaging (CI). SSTR-PET should replace In-111 pentetreotide scintigraphy (OctreoScan) in all indications in which SSTR scintigraphy is currently being used. These appropriate use criteria (AUC) are intended to aid referring medical practitioners in the appropriate use of SSTR-PET for imaging of patients with NETs, and the indications were evaluated in well-differentiated NETs...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28980780/-changes-in-the-new-tnm-classification-in-head-and-neck-oncology
#7
Silvia Lambiel, Pavel Dulguerov
The Union for International Cancer Control (UICC) published in 2017 a revised 8th edition of the TNM classification bringing numerous changes in the classification of head and neck tumors. Three new entities were introduced, namely HPV-positive oropharyngeal carcinoma, neck metastasis from an unknown primary, and skin carcinoma of the head and neck. Going beyond the traditional size of the lesions, several new predictive factors have been included, such as the depth of invasion of oral carcinoma and the extracapsular spread of neck metastasis...
October 4, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28977975/prognostic-clinicopathologic-factors-in-carcinoma-of-unknown-primary-origin-a-study-of-106-consecutive-cases
#8
Junjeong Choi, Ji Hae Nahm, Sang Kyum Kim
A heterogeneous group of cancers for which the site of origin remains occult after detailed investigations is defined as carcinomas of unknown primary origin (CUPs). Because patients with CUP have a dismal prognosis, we have analyzed CUPs to highlight the implication of clinicopathologic factors related with patient survival. A total of 106 consecutive cases of CUP were collected. A two-step strategy of immunohistochemistry to assess CUPs according NCCN Guidelines is used to separate carcinomatous tumors and subtype carcinomas...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976427/quality-of-life-of-patients-with-spinal-metastasis-from-cancer-of-unknown-primary-origin-a-longitudinal-study-of-surgical-management-combined-with-postoperative-radiation-therapy
#9
Yifei Ma, Shaohui He, Tielong Liu, Xinghai Yang, Jian Zhao, Hongyu Yu, Jiaojiao Feng, Wei Xu, Jianru Xiao
BACKGROUND: Patients with spinal metastasis from cancer of unknown primary origin have limited life expectancy and poor quality of life. Surgery and radiation therapy remain the main treatment options, but, to our knowledge, there are limited data concerning quality-of-life improvement after surgery and radiation therapy and even fewer data on whether surgical intervention would affect quality of life. METHODS: Patients were enrolled between January 2009 and January 2014 at the Changzheng Hospital, Shanghai, People's Republic of China...
October 4, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28974397/comprehensive-genomic-sequencing-of-urothelial-tumors-identifies-rare-smarcb1-ini-1-deficient-carcinomas-of-the-urinary%C3%A2-system
#10
Sumati Gupta, Daniel Albertson, David Gaston, Marta E Heilbrun, Neeraj Agarwal, Ken Boucher, Timothy J Parnell, Ting Liu, Alicia Morgans, Russell Madison, Kyle Gowen, Vincent A Miller, Jeffrey S Ross, Siraj M Ali, Sherri Z Millis
PURPOSE: Tumor genomic profiling helps direct therapy for advanced urothelial carcinoma (UC). In the course of clinical care, we encountered a patient with a complete loss of SMARCB1 (switch/sucrose nonfermentable-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1), which encodes INI-1 (integrase interactor 1), as the sole detected driver of their urinary tract tumor. Our objective was the identification and genomic characterization of urinary tract neoplasia with complete SMARCB1 loss...
September 7, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28969691/pregnancy-associated-cancer-in-the-french-west-indies-martinique-maternal-and-neonatal-outcomes
#11
Kathleen Melan, Jean-Luc Volumenie, Gaël Wan-Ajouhu, Stephen Ulric-Gervaise, Jacqueline Veronique-Baudin, Clarisse Joachim
BACKGROUND: The management of pregnancy-associated-cancer (PAC) requires epidemiological evaluation of the pathways of care. The aim of this study was to describe maternal and neonatal outcomes of PAC in Martinique. METHODS: A retrospective study was conducted using data from medical records and the Martinique Cancer Registry for all PAC diagnosed between 1st January 2000 and 31st December 2014. RESULTS: Eighteen women were diagnosed with PAC: 17 during pregnancy and one during the postpartum period...
October 2, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28968158/satb2-as-an-immunohistochemical-marker-for-colorectal-adenocarcinoma-a-concise-review-of-benefits-and-pitfalls
#12
REVIEW
Kyra B Berg, David F Schaeffer
SATB2 is part of the family of matrix attachment region-binding transcription factors, and has developmental roles in craniofacial, neural, and osteoblastic differentiation. Recently, SATB2 has been shown to be highly expressed in the epithelium of the lower gastrointestinal tract, with a relatively narrow expression profile in malignancies, including colorectal/appendiceal adenocarcinomas, tumors of osteoblastic differentiation, and renal/urothelial carcinomas. SATB2 has gained interest as a relatively specific marker of colorectal differentiation, with potential applications including determining origin of adenocarcinomas of unknown primary and distinguishing primary ovarian mucinous adenocarcinomas from colorectal metastases...
October 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28963312/differences-in-experiences-of-care-between-patients-diagnosed-with-metastatic-cancer-of-known-and-unknown-primaries-mixed-method-findings-from-the-2013-cancer-patient-experience-survey-in-england
#13
Richard Wagland, Mike Bracher, Allison Drosdowsky, Alison Richardson, John Symons, Linda Mileshkin, Penny Schofield
OBJECTIVES: To explore differences in experiences of care reported in the Cancer Patient Experience Survey (CPES) between patients with cancer of unknown primary (CUP) and those with metastatic disease of known primary (non-CUP); to determine insights pertaining to the experiences of care for CUP respondents from free-text comments. DESIGN: Two separate, but related, studies, involving secondary analysis of existing data. Using frequency matching of CUP and non-CUP patients, statistical comparisons of responses to CPES questions were conducted...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28958067/an-intra-aortic-floating-metastatic-malignancy-of-unknown-primary-origin
#14
Yoshinori Kuroda, Tetsuro Uchida, Jun Hayashi, Mitsuaki Sadahiro
A 69-year-old man with sudden strong back pain was transported to our hospital by ambulance. The computed tomography scan revealed an intra-aortic floating mass with a stalk arising from the descending aortic wall, which was thought to be a thrombus. The floating mass displayed the characteristics of a thrombus rather than a neoplastic tumour on magnetic resonance imaging scan. Under extracorporeal circulation, the descending aorta was cut open, and the mass was resected. Subsequently, a stent graft was placed to cover the abnormal aortic intima to prevent recurrent thrombus formation...
August 29, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28951274/spinal-metastasis-of-unknown-primary-accompanied-by-neurological-deficit-or-vertebral-instability
#15
Abdurrahman Aycan, Sebahattin Çelik, Fetullah Kuyumcu, Mehmet Edip Akyol, Mehmet Arslan, Erkan Doğan, Harun Arslan
INTRODUCTION AND AIM: Spinal bone metastases are highly common. They are mostly localized to the lumbar, thoracic, and cervical spine, respectively. The most common primaries to result in spinal metastases include lung, breast, and prostate carcinomas in adults as opposed to leukemia, Ewing's sarcoma, rhabdomyosarcoma, and neuroblastoma in children. In patients diagnosed with a cancer, bone metastases are found in 40% and spinal metastases in 10% of the patients. In this study, we aimed to present 25 patients diagnosed with a spinal metastasis of unknown primary who presented with a low back pain or acute-onset neurological deficits and underwent operative treatment...
September 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28944768/a-large-metastatic-intramammary-lesion-of-an-occult-melanoma
#16
Eleonora Nacchiero, Stefania Stucci, Paolo Annoscia, Michelangelo Vestita, Rossella Elia, Paolo Claudio Marannino
OBJECTIVE: Malignant melanomas presenting with unknown primaries are uncommon. In the majority of cases metastases of occult melanoma were detected in skin or in lymph nodes. Melanoma can rarely occur as a primary or metastatic intramammary tumor. CASE REPORT: We report the case of a 58-year-old Caucasian woman who came to our department with a voluminous mass in her right breast. Histopathological examination found metastasis of epithelioid melanoma with unknown primary lesion...
September 4, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28937454/life-expectancy-and-metastatic-spine-scoring-systems-an-academic-institutional-experience
#17
Brian T Ragel, Gustavo A Mendez, Justin Reddington, David Ferachi, Charlotte D Kubicky, Travis C Philipp, Natalie L Zusman, Paul Klimo, Robert Hart, Jung Yoo, Alex C Ching
STUDY DESIGN: A retrospective data collection study with application of metastatic spine scoring systems. OBJECTIVES: To apply the Tomita and revised Tokuhashi scoring systems to a surgical cohort at a single academic institution and analyze spine-related surgical morbidity and mortality rates. SUMMARY OF BACKGROUND DATA: Surgical management of metastatic spine patients requires tools that can accurately predict patient survival, as well as knowledge of morbidity and mortality rates...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28933519/skin-metastasis-review-with-conceptual-and-practical-guide
#18
Martin R Dittmer, Vincent Liu
Of the outward manifestations of visceral malignancy, cutaneous metastases are of particular interest for their impact on identification, prognosis, and management of the primary tumor. Their diagnosis is often challenging and requires high clinical suspicion. The infrequency and clinicopathologic variability of cutaneous metastases can impede their recognition by physical exam and even histopathology. This review offers a practical approach to judicious utilization of the full repertoire of clinical and pathologic data in precise characterization of metastases to the skin...
September 20, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28925524/hypothermia-increases-aquaporin-4-aqp4-plasma-membrane-abundance-in-human-primary-cortical-astrocytes-via-a-calcium-transient-receptor-potential-vanilloid-4-trpv4-and-calmodulin-mediated-mechanism
#19
Mootaz M Salman, Philip Kitchen, M Nicola Woodroofe, James E Brown, Roslyn M Bill, Alex C Conner, Matthew T Conner
Human aquaporin 4 (AQP4) is the primary water channel protein in brain astrocytes. Hypothermia is known to cause astrocyte swelling in culture, but the precise role of AQP4 in this process is unknown. Primary human cortical astrocytes were cultured under hypothermic (32°C) or normothermic (37°C) conditions. AQP4 transcript, total protein and surface localized protein were quantified using RT-qPCR, sandwich ELISA with whole cell lysates, or cell-surface biotinylation followed by ELISA analysis of the surface-localized protein, respectively...
September 19, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28921531/a-naive-bayes-algorithm-for-tissue-origin-diagnosis-tod-bayes-of-synchronous-multifocal-tumors-in-the-hepatobiliary-and-pancreatic-system
#20
Weiqin Jiang, Yifei Shen, Yongfeng Ding, Chuyu Ye, Yi Zheng, Peng Zhao, Lulu Liu, Zhou Tong, Linfu Zhou, Shuo Sun, Xingchen Zhang, Lisong Teng, Michael P Timko, Longjiang Fan, Weijia Fang
Synchronous multifocal tumors are common in the hepatobiliary and pancreatic system but because of similarities in their histological features, oncologists have difficulty in identifying their precise tissue clonal origin through routine histopathological methods. To address this problem and assist in more precise diagnosis, we developed a computational approach for tissue origin diagnosis based on naive Bayes algorithm (TOD-Bayes) using ubiquitous RNA-Seq data. Massive tissue-specific RNA-Seq data sets were first obtained from The Cancer Genome Atlas (TCGA) and ∼1,000 feature genes were used to train and validate the TOD-Bayes algorithm...
September 16, 2017: International Journal of Cancer. Journal International du Cancer
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