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https://www.readbyqxmd.com/read/28932574/lung-allocation
#1
REVIEW
Jens Gottlieb
Shortage of donor lungs in most western countries and broadening of indications for lung transplantation (LTx) has led increased waiting list mortality in the past. Usually donor lungs and recipients are matched by size as measured by total lung capacity and blood type in first order. In some countries regional allocation comes first, in other countries a national wait list exists and some nations are organized in supranational allocation systems. Organ distribution should respect the ethical principles of equity, justice, beneficence and utility...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932573/donors-after-cardiocirculatory-death-and-lung-transplantation
#2
REVIEW
Ilhan Inci
The number of patients actively awaiting lung transplantation (LTx) is more than the number of suitable donor lungs. The percentage of lung retrieval rate is lower when compared to other solid organs. The use of lungs from donation after cardiocirculatory death (DCD) donors is one of the options to avoid organ shortage in LTx. After extensive experimental research, clinical application of DCD donation is becoming wider. The results from most of the centers show at least equal survival rate compared to donors from brain death...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932229/association-between-a-single-donor-tarc-ccl17-promotor-polymorphism-and-obstructive-chronic-lung-allograft-dysfunction-after-lung-transplantation
#3
Kevin Budding, Jessica van Setten, Eduard A van de Graaf, Oliver A van Rossum, Tineke Kardol-Hoefnagel, Erik-Jan D Oudijk, C Erik Hack, Henderikus G Otten
Lung transplantation (LTx) outcome is hampered by development of chronic rejection, often manifested as the bronchiolitis obliterans syndrome (BOS). Low serum levels of thymus and activation-regulated chemokine (TARC/CCL17), a chemoattractant, measured during the first month post-LTx are predictive for BOS development. Since TARC/CCL17 promotor polymorphisms correlate with serum TARC/CCL17 levels, we investigated seven single-nucleotide polymorphisms (SNPs) within this region and their potential association with LTx outcome...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28924464/the-relationship-between-mortality-of-lung-transplant-recipients-and-serum-cyclosporine-levels-joint-modeling-of-time-to-event-data-and-longitudinal-data
#4
F S Hosseini-Baharanchi, E Hajizadeh, A R Baghestani, K Najafzadeh
BACKGROUND: Lung transplantation (LTx) is a well-accepted treatment that can prolong survival of patients with advanced lung disease. OBJECTIVE: To evaluate the association between serum cyclosporine level (SCL) pattern and mortality of LTx recipients. METHODS: This retrospective cohort study included 1019 observations on 38 patients who underwent LTx in Masih Daneshvari Hospital from 2000 to 2013. The analysis applied a joint model with shared random effects...
2017: International Journal of Organ Transplantation Medicine
https://www.readbyqxmd.com/read/28923643/feasibility-of-lung-transplantation-from-donation-after-circulatory-death-donors-following-portable-ex%C3%A2-vivo-lung-perfusion-a-pilot-study
#5
J G Y Luc, K Jackson, J G Weinkauf, D H Freed, J Nagendran
BACKGROUND: Donation after circulatory death (DCD) has the potential to significantly alleviate the shortage of transplantable lungs. We report our initial experience with the use of portable ex vivo lung perfusion (EVLP) with the Organ Care System Lung device for evaluation of DCD lungs. METHODS: We performed a retrospective review of the DCD lung transplantation (LTx) experience at a single institution through the use of a prospective database. RESULTS: From 2011 to 2015, 208 LTx were performed at the University of Alberta, of which 11 were DCD LTx with 7 (64%) that underwent portable EVLP...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28920000/oncolytic-peptide-ltx-315-induces-an-immune-mediated-abscopal-effect-in-a-rat-sarcoma-model
#6
Janne Nestvold, Meng-Yu Wang, Ketil A Camilio, Severin Zinöcker, Torunn Elisabeth Tjelle, Alf Lindberg, Bengt Erik Haug, Gunnar Kvalheim, Baldur Sveinbjørnsson, Øystein Rekdal
LTX 315 is an oncolytic peptide with potent immunological properties. In the present study, we demonstrate that intratumoral treatment with LTX-315 resulted in a complete regression and systemic immune response in a rat fibrosarcoma model. The treatment was T-cell dependent, and also resulted in an abscopal effect as demonstrated by the regression of distal non-treated lesions. Significant infiltration of CD8(+) T cells was observed in both treated and non-treated lesions, as shown by immunohistochemical and flow cytometric analysis...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28910513/quality-of-life-outcomes-following-pediatric-lung-transplantation
#7
Tanya Lazor, Hartmut Grasemann, Melinda Solomon, Samantha J Anthony
PURPOSE: Compared to other solid organs, survival after lung transplantation (LTx) is still poor. Discussions on survival benefits following LTx in children, however, have largely concentrated on medical outcome data. Little research describes quality of life (QoL) of pediatric LTx recipients, which is partly due to the small number of pediatric LTxs performed. Only two centers worldwide performed >10 pediatric LTxs in 2013, making data on QoL in this population difficult to obtain...
September 14, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28889654/patient-reported-health-outcomes-in-long-term-lung-transplant-survivors-a-prospective-cohort-study
#8
A Shahabeddin Parizi, P F M Krabbe, E A M Verschuuren, R A S Hoek, J M Kwakkel-van Erp, M E Erasmus, W van der Bij, K M Vermeulen
During the last 3 decades lung transplantation (LTx) has become a proven modality to increase both survival and health-related quality of life (HRQoL) in patients with various end-stage lung diseases. Most previous studies have reported improved HRQoL shortly after LTx. With regard to long-term effects on HRQoL, however, the evidence is less solid. This prospective cohort study was started with 828 patients who were on the waiting list for LTx. Then, in a longitudinal follow-up, 370 post-LTx patients were evaluated annually for up to 15 years...
September 10, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28887331/shock-and-lethality-with-anthrax-edema-toxin-in-rats-are-associated-with-reduced-arterial-responsiveness-to-phenylephrine-and-are-reversed-with-adefovir
#9
Dante Alexander Suffredini, Yan Li, Wanying Xu, Mahtab Moayeri, Stephen H Leppla, Yvonne Fitz, Xizhong Cui, Peter Q Eichacker
INTRODUCTION: Although edema (ETx) and lethal toxin (LTx) contribute to B. anthracis shock and lethality, mechanisms underlying their cardiovascular effects are unclear. We previously showed that ETx but not LTx inhibited phenylephrine stimulated contraction of aortic rings prepared from healthy rats and adefovir, a selective inhibitor of ETx cAMP production, blocked this effect. Here we examined arterial function in rats receiving 24h ETx or LTx infusions. METHODS AND RESULTS: Compared to controls, ETx reduced mean arterial pressure (MAP) and survival over 48h (p≤0...
September 8, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28871617/what-is-expected-in-lung-function-after-lung-transplantation-due-to-end-stage-pulmonary-silicosis
#10
Luzielio Alves Sidney, Guilherme Watte, Pedro Augusto Reck Dos Santos, Sadi Marcelo Schio, Spencer Marcelo Camargo, Fabíola Adélia Perin, Bruno Hochhegger, Jose Carlos Felicetti, Jose de Jesus Peixoto Camargo, Jose da Silva Moreira
In the present study, we aimed to determine the impact of lung transplantation (LTx) on pulmonary function tests (PFTs) and survival among patients with end-stage silicosis. We included patients with end-stange silicosis on the wait list for LTx, between January 1989 and July 2015 (N=26). Sixteen of these patients received LTx; 10 were eligible, but did not undergo LTx (non-LTx) during the study period. Retrospective information on PFTs (spirometry [volumes and flows], 6-minute walking test [6MWT], and DLCO) was retrieved from patients' medical charts, including baseline information for all patients, and follow-up information for the LTx...
September 4, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28871078/impact-of-forced-expiratory-volume-in-1-second-fev1-and-6-minute-walking-distance-at-3-6-and-12-months-and-annually-on-survival-and-occurrence-of-bronchiolitis-obliterans-syndrome-bos-after-lung-transplantation
#11
Mohammed Fakhro, Richard Ingemansson, Lars Algotsson, Sandra Lindstedt
BACKGROUND Development of bronchiolitis obliterans syndrome (BOS) is a great limitation for patient survival in lung transplantation (LTx). A curative treatment for BOS is still missing, and in terminal stages re-transplantation (Re-LTx) is the only salvation. It is possible to slow the progress of BOS if it is detected at an early stage. This might be possible by assessing pulmonary function pattern. MATERIAL AND METHODS Between 1990 and 2014, 278 patients underwent LTx at Skåne University Hospital, Sweden...
September 5, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28868123/orthotopic-liver-transplantation-from-cardiac-death-donors-in-the-mouse-a-new-model-and-evaluation-of-cardiac-death-time
#12
Zhenzhen Liu, Ning Pan, Xiangwei Lv, Song Li, Liming Wang, Qinlong Liu
OBJECTIVES: The goal of this research was to develop a mouse orthotopic liver transplantation (LTx) model from donor-after-cardiac-death (DCD) grafts. MATERIALS AND METHODS: Mice were randomly assigned to the experimental group or the sham group. The mice in the experimental group were divided into three groups according to the warm ischemia time (WIT) of liver graft: normal LTx, WIT 30 minute (min) +LTx and WIT 45 min +LTx. The descending aorta was clamped using a miniature aortic clamp to simulate cardiac arrest in the DCD grafts...
June 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28858970/lung-transplantation-in-cystic-fibrosis-patients-with-difficult-to-treat-lung-infections
#13
Lieven Dupont
PURPOSE OF REVIEW: In cystic fibrosis (CF) patients with end-stage pulmonary disease, lung transplantation (LTx) remains a life-extending therapy with good outcome in most patients. Despite early concern about chronic pretransplantation infections in the context of posttransplantation immunosuppression, typical CF-associated organisms such as Pseudomonas aeruginosa turned out to be quite well manageable and associated with favorable outcomes in transplanted CF patients, even in patients with highly resistant strains...
August 30, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28858433/getting-to-transplantation
#14
EDITORIAL
Michael S Mulvihill, Matthew G Hartwig
Candidates for lung transplantation (LTX) are increasingly critically-ill at the time of transplantation, and as such more often require invasive support strategies to bridge to transplant (1). Traditionally, this required invasive Mechanical Ventilation (iMV), and today more frequently includes the use of Extra-Corporeal Membrane Oxygenation (ECMO) to achieve adequate gas exchange. While there has been concern regarding futility of transplantation in such critically-ill cohorts due to early experience, post-transplant survival has steadily improved in the highest LAS quartile candidates (2)...
August 31, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28844151/high-dose-acyclovir-for-cytomegalovirus-prophylaxis-in-seropositive-abdominal-transplant-recipients
#15
Margaret R Jorgenson, Jillian L Descourouez, Glen E Leverson, Erin K McCreary, Michael R Lucey, Jeannina A Smith, Robert R Redfield
BACKGROUND: Following abdominal solid organ transplant (aSOT), valganciclovir (VGC) is recommended for cytomegalovirus (CMV) prophylaxis. This agent is associated with efficacy concerns, toxicity, and emergence of ganciclovir resistance. OBJECTIVE: To evaluate the incidence of high-dose acyclovir (HD-A) prophylaxis failure in seropositive aSOT recipients (R+). METHODS: This was a retrospective, single-center study of R+ transplanted without lymphocyte-depleting induction between January 1, 2000, and June 30, 2013, discharged with 3 months of HD-A prophylaxis (800 mg 4 times daily)...
August 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28840631/domiciliary-non-invasive-ventilation-post-lung-transplantation
#16
Sakhee Kotecha, Catherine Buchan, Kerry Parker, Jo Toghill, Eldho Paul, Belinda Miller, Matthew Naughton, Gregory Snell, Eli Dabscheck
BACKGROUND AND OBJECTIVE: The benefits of domiciliary non-invasive ventilation (NIV) post lung transplantation (LTx) have not previously been described. This was a single-centre retrospective audit of patients requiring domiciliary NIV post-LTx. Our aim was to describe indications for NIV and outcomes in chronic lung allograft dysfunction (CLAD) and diaphragmatic palsy. METHODS: All patients requiring domiciliary NIV post-LTx between 2010 and June 2016 were assessed...
August 24, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28838436/early-postoperative-problems-after-lung-transplantation-first-year-experiences-in-light-of-the-newly-established-national-hungarian-lung-transplantation-program
#17
I Madurka, J Elek, N Schönauer, T Bartók, K Kormosói-Tóth, P Radeczky, B Gieszer, Á Ghimessy, G Lang, W Klepetko, F Rényi-Vámos
Until December 2015, Hungarian patients' lung transplantations (LTXs) were done at the Medical University of Vienna. After several years of preparation, the National Hungarian Lung Transplantation Program was launched and the first milestone LTX was performed in Budapest on December 12, 2015. During the first 12 months, 18 lung transplantations took place in Hungary, including the first one. Data were retrospectively collected to analyze the early postoperative problems of the first 18 LTX patients of the newly launched Hungarian National Lung Transplantation Program...
September 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28834194/pediatric-liver-transplantation-for-hepatocellular-cancer-and-rare-liver-malignancies-us-multi-and-single-center-experience-1981-2015
#18
Rohan Vinayak, Ruy J Cruz, Sarangarajan Ranganathan, Ravi Mohanka, George Mazariegos, Kyle Soltys, Geoff Bond, Sameh Tadros, Abhinav Humar, J Wallis Marsh, Robert R Selby, Jorge Reyes, Kimberly Haberman, Rakesh Sindhi
Pediatric liver transplantation (LTx) is increasingly performed for rare unresectable liver malignancies other than hepatoblastoma (HBL). PURPOSE: We performed a retrospective review of outcomes after LTx for malignancy in the multi-center US Scientific Registry for Transplant Recipients (SRTR, n=677, 1987-2015). We then reviewed the Children's Hospital of Pittsburgh (CHP, n=74, 1981-2014) experience focusing on LTx for unresectable hepatocellular cancer (HCC), non-HBL embryonal tumors (EMB) and metastatic liver tumors (METS)...
August 17, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28833662/survival-after-lung-transplantation-in-recipients-with-alpha-1-antitrypsin-deficiency-compared-to-other-forms-of-chronic-obstructive-pulmonary-disease-a-national-cohort-study
#19
Brian C Gulack, Michael S Mulvihill, Asvin M Ganapathi, Paul J Speicher, Godefroy Chery, Laurie D Snyder, R Duane Davis, Matthew G Hartwig
INTRODUCTION: Alpha-1-Antitrypsin deficiency (AATD) is grouped with chronic obstructive pulmonary disease (COPD); however, this may not be appropriate. This study assessed whether AATD confers a different prognosis than COPD following lung transplantation. METHODS: We employed the UNOS database, grouping patients by diagnoses of AATD or COPD. Kaplan-Meier methods and Cox modeling were performed to determine the association of diagnosis and overall survival. RESULTS: Of 9569 patients, 1394 (14...
August 23, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28825952/the-impact-of-waiting-list-bmi-changes-on-the-short-term-outcomes-of-lung-transplantation
#20
Valérie Jomphe, Geneviève Mailhot, Véronic Damphousse, Muhammad-Ramzan Tahir, Olivier Receveur, Charles Poirier, Pasquale Ferraro
BACKGROUND: Obesity and underweight are associated with a higher postlung transplantation (LTx) mortality. This study aims to assess the impact of the changes in BMI during the waiting period for LTx on early postoperative outcomes. METHODS: Medical records of 502 consecutive cases of LTx performed at our institution between 1999 and 2015 were reviewed. Patients were stratified per change in BMI category between pre-LTx assessment (candidate BMI) and transplant BMI as follows: A-Candidate BMI<18...
August 18, 2017: Transplantation
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