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Pre operative lung transplant

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https://www.readbyqxmd.com/read/27569957/severe-sepsis-after-living-donor-liver-transplantation-risk-factors-and-outcomes
#1
K Takeda, Y Sawada, T Kumamoto, K Tanaka, I Endo
BACKGROUND: The post-operative mortality and morbidity rates associated with living-donor liver transplantation (LDLT) are still relatively high. Several papers have reported the risk factors associated with post-operative infectious complications, but few have analyzed the risk factors with respect to the severity of sepsis. The aim of this study was to clarify the risk factors that affect severe sepsis after LDLT. METHODS: For 63 LDLT patients at our institute, we compared peri-operative characteristics in 29 patients who developed sepsis after surgery and 34 patients who did not...
July 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27548238/physical-activity-and-exertional-desaturation-are-associated-with-mortality-in-idiopathic-pulmonary-fibrosis
#2
Baruch Vainshelboim, Mordechai Reuven Kramer, Shimon Izhakian, Ricardo M Lima, Jose Oliveira
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that manifests in hypoxemia, inactivity, and poor prognosis. This study aimed to assess the prognostic role of physical activity (PA) and exertional desaturation (ED) with mortality in IPF. At baseline, 34 IPF patients (68 (50-81) years) were interviewed using the International Physical Activity Questionnaire (IPAQ), and SpO₂ was assessed pre to post 6-min walking test (∆SpO₂). Patients were prospectively followed up for 40 months. Receiver operating characteristics curve analysis determined cut-off points associated with mortality, and Cox proportional hazard ratio (HR) were conducted...
2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27367568/parametric-response-mapping-of-bronchiolitis-obliterans-syndrome-progression-after-lung-transplantation
#3
Stijn E Verleden, Robin Vos, Elly Vandermeulen, David Ruttens, Hannelore Bellon, Tobias Heigl, Dirk E Van Raemdonck, Geert M Verleden, Vibha Lama, Brian D Ross, Craig J Galbán, Bart M Vanaudenaerde
Bronchiolitis obliterans syndrome (BOS) remains a major complication after lung transplantation. Air trapping and mosaic attenuation are typical radiological features of BOS, however quantitative evaluation remains troublesome. We evaluated parametric response mapping (PRM, voxel-to-voxel comparison of inspiratory and expiratory CT scans) in lung transplant recipients diagnosed with BOS (n=20) and time-matched stable lung transplant recipients (n=20). Serial PRM measurements were performed pre-diagnosis, at time of BOS diagnosis and post-diagnosis (Tpre , T0 and Tpost respectively); or at a post-operatively matched time in stable patients...
July 1, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27266805/how-important-is-coronary-artery-disease-when-considering-lung-transplant-candidates
#4
Marijan Koprivanac, Marie M Budev, James J Yun, Marta Kelava, Gösta B Pettersson, Kenneth R McCurry, Douglas R Johnston, Abeel A Mangi, Penny L Houghtaling, Eugene H Blackstone, Sudish C Murthy
BACKGROUND: Coronary artery disease (CAD) remains a relative contraindication for lung transplantation, but should it be if amenable to effective palliation? METHODS: From January 2005 to July 2010, 356 adults undergoing primary lung transplantation had no significant (<50%) coronary arterial stenosis and 70 had significant (≥50%) CAD requiring prior or concomitant revascularization. Propensity matching on 38 pre-transplant patient characteristics identified 61 well-matched pairs (87% of possible matches) and 295 no-CAD unmatched patients to compare post-operative morbidity, graft function, and time-related pulmonary function and survival...
March 30, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27105687/evidence-supports-severe-renal-insufficiency-as-a-relative-contraindication-to-heart-transplantation
#5
Kimberly N Hong, Aurelie Merlo, Dhaval Chauhan, Ryan R Davies, Alexander Iribarne, Elizabeth Johnson, Val Jeevanandam, Mark J Russo
BACKGROUND: This study was conducted to determine whether survival after orthotopic heart transplant (OHT) is associated with pre-transplant estimated glomerular filtration rate (eGFR) and to define ranges of pre-OHT eGFR associated with differences in post-transplant survival. The 2006 International Society for Heart and Lung Transplantation revised listing criteria for OHT stated that chronic kidney disease, defined by an eGFR <40 ml/min is a relative contraindication for OHT alone...
July 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/26996929/outcome-incidence-and-risk-factors-for-stroke-after-pediatric-heart-transplantation-an-analysis-of-the-international-society-for-heart-and-lung-transplantation-registry
#6
Conall T Morgan, Cedric Manlhiot, Brian W McCrindle, Anne I Dipchand
BACKGROUND: In the registry of the International Society for Heart and Lung Transplantation (ISHLT), cerebrovascular accidents are the fifth most common cause for mortality after pediatric heart transplantation (PHTx), but details are lacking in the literature. The purpose of this analysis of the ISHLT registry was to determine the prevalence, risk factors and outcomes of stroke after PHTx. METHODS: Data from the ISHLT registry (1998 to 2010) were used to identify all patients whose primary transplantation was performed at <18 years of age...
May 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/26796350/circulating-cell-death-biomarkers-may-predict-survival-in-human-lung-transplantation
#7
Kohei Hashimoto, Rickvinder Besla, Ricardo Zamel, Stephen Juvet, Hyunhee Kim, Sassan Azad, Thomas K Waddell, Marcelo Cypel, Mingyao Liu, Shaf Keshavjee
RATIONALE: Immediate graft performance after lung transplantation is associated with short- and long-term clinical outcomes. However, the biologic mechanism that determines outcomes is not fully understood. OBJECTIVES: To investigate the impact of cell death signals at 24 and 48 hours after lung transplantation on short- and long-term clinical outcomes. METHODS: Plasma samples were collected pretransplantation and at 24 and 48 hours after transplant from 60 bilateral lung transplant recipients...
July 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26663465/the-role-of-cardiopulmonary-bypass-in-lung-transplantation
#8
Prashant N Mohite, Anton Sabashnikov, Nikhil P Patil, Diana Garcia-Saez, Bartlomeij Zych, Mohamed Zeriouh, Rosalba Romano, Simona Soresi, Anna Reed, Martin Carby, Fabio De Robertis, Toufan Bahrami, Mohamed Amrani, Nandor Marczin, Andre R Simon, Aron-Frederik Popov
BACKGROUND: The risk-benefit for utilizing cardio-pulmonary bypass (CPB) in lung transplantation (LTx) remains debatable. This study compares outcomes after LTx utilizing different CPB strategies - elective CPB vs. off-pump vs. off-pump with unplanned conversion to CPB. METHODS: A total of 302 LTx performed over seven yr were divided into three groups: "off-pump" group (n = 86), "elective on-pump" group (n = 162), and "conversion" group (n = 54). The preoperative donor and recipient demographics and baseline characteristics and the postoperative outcomes were analyzed; 1:1 propensity score matching was used to identify patients operated upon using elective CPB who had risk profiles similar to those operated upon off-pump (propensity-matching 1) as well as those emergently converted from off-pump to CPB (propensity-matching 2)...
March 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/26488418/lung-transplantation-in-alpha-1-antitrypsin-deficiency
#9
Helen Marie Stone, Ross Gareth Edgar, Richard Damian Thompson, Robert Andrew Stockley
BACKGROUND: Lung transplantation is a therapeutic option for patients with end-stage lung disease and a survival benefit has been described in patients with alpha-1-antitrypsin deficiency (A1ATD). The aims of the current study were to determine the survival and health benefits of lung transplantation in UK patients with A1ATD compared to carefully matched non-transplant patients. METHODS: Patients with the PiZZ (alpha-1-antitrypsin deficiency) genotype who had undergone lung transplantation between 1996 and 2011 were identified from the UK A1ATD registry...
2016: COPD
https://www.readbyqxmd.com/read/26452997/impact-of-pre-operative-coronary-artery-disease-on-cardiovascular-events-following-lung-transplantation
#10
Kongkiat Chaikriangkrai, Soma Jyothula, Hye Yeon Jhun, Jerry Estep, Matthias Loebe, Scott Scheinin, Guillermo Torre-Amione
BACKGROUND: This study examined the correlation between pre-operative coronary artery disease (CAD) and post-operative cardiovascular events in lung transplant recipients. METHODS: Consecutive isolated lung transplant recipients from 2007 to 2013 in our institution were identified and categorized as having significant CAD (≥ 50% coronary stenosis in at least 1 artery or history of coronary revascularization) or no-mild CAD. Patient records and death index data were analyzed for a median of 2 years for death or cardiovascular events, including coronary, cerebrovascular, and peripheral artery events...
January 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/26290637/pre-lung-transplant-measures-of-reflux-on-impedance-are-superior-to-ph-testing-alone-in-predicting-early-allograft-injury
#11
Wai-Kit Lo, Robert Burakoff, Hilary J Goldberg, Natan Feldman, Walter W Chan
AIM: To evaluate pre-lung transplant acid reflux on pH-testing vs corresponding bolus reflux on multichannel intraluminal impedance (MII) to predict early allograft injury. METHODS: This was a retrospective cohort study of lung transplant recipients who underwent pre-transplant combined MII-pH-testing at a tertiary care center from January 2007 to November 2012. Patients with pre-transplant fundoplication were excluded. Time-to-event analysis was performed using a Cox proportional hazards model to assess associations between measures of reflux on MII-pH testing and early allograft injury...
August 14, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26275639/a-novel-risk-score-that-incorporates-recipient-and-donor-variables-to-predict-1-year-mortality-in-the-current-era-of-lung-transplantation
#12
Joshua C Grimm, Vicente Valero, J Trent Magruder, Arman Kilic, Samuel P Dungan, Leann L Silhan, Pali D Shah, Bo S Kim, Christian A Merlo, Christopher M Sciortino, Ashish S Shah
BACKGROUND: In this study we sought to construct a novel scoring system to pre-operatively stratify a patient's risk of 1-year mortality after lung transplantation (LTx) based on recipient- and donor-specific characteristics. METHODS: The UNOS database was queried for adult (≥18 years) patients undergoing LTx between May 1, 2005 and December 31, 2012. The population was randomly divided in a 4:1 fashion into derivation and validation cohorts. A multivariable logistic regression model for 1-year mortality was constructed within the derivation cohort...
November 2015: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/26169669/influence-of-right-ventricular-function-on-the-development-of-primary-graft-dysfunction-after-lung-transplantation
#13
Purificación Pérez-Terán, Oriol Roca, José Rodríguez-Palomares, Judit Sacanell, Sandra Leal, Joan Solé, María I Rochera, Antonio Román, Juan C Ruiz-Rodríguez, Joaquim Gea, Arturo Evangelista, Joan R Masclans
BACKGROUND: Primary graft dysfunction (PGD) remains a significant cause of lung transplant postoperative morbidity and mortality. The underlying mechanisms of PGD development are not completely understood. This study analyzed the effect of right ventricular function (RVF) on PGD development. METHODS: A retrospective analysis of a prospectively assessed cohort was performed at a single institution between July 2010 and June 2013. The primary outcome was development of PGD grade 3 (PGD3)...
November 2015: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/26065882/persistent-hypoxemia-and-platypnea-orthodeoxia-after-left-single-lung-transplantation-a-case-report
#14
Hamza Salim, Jose Melendez, Harish Seethamraju
INTRODUCTION: Platypnea-orthodeoxia is a relatively uncommon but striking clinical syndrome characterized by dyspnea and deoxygenation accompanying a change to sitting or standing from a recumbent position. Hypoxemia early after lung transplant can have multiple etiologies. We report a rare case of persistent hypoxemia and platypnea-orthodeoxia after left single-lung transplantation, as a result of right-to-left interatrial shunt through a patent foramen ovale, with subsequent resolution of hypoxemia after percutaneous closure of the patent foramen ovale...
June 12, 2015: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/25940517/impact-of-clad-phenotype-on-survival-after-lung-retransplantation-a-multicenter-study
#15
MULTICENTER STUDY
S E Verleden, J L Todd, M Sato, S M Palmer, T Martinu, E N Pavlisko, R Vos, A Neyrinck, D Van Raemdonck, T Saito, H Oishi, S Keshavjee, M Greer, G Warnecke, J Gottlieb, A Haverich
Chronic lung allograft dysfunction (CLAD) remains a major problem after lung transplantation with no definitive treatment except redo lung transplantation (re-LTx) in selected candidates. However, CLAD is not a homogeneous entity and different phenotypes exist. Therefore, we aimed to evaluate the effect of CLAD phenotypes on survival after re-LTx for CLAD. Patients who underwent re-LTx for respiratory failure secondary to CLAD in four LTx centers between 2003 and 2013 were included in this retrospective analysis...
August 2015: American Journal of Transplantation
https://www.readbyqxmd.com/read/25689144/do-chest-expansion-exercises-aid-re-shaping-the-diaphragm-within-the-first-72%C3%A2-hours-following-lung-transplantation-in-a-usual-interstitial-pneumonia-patient
#16
Massimiliano Polastri, Erika Venturini, Saverio Pastore, Andrea Dell'Amore
BACKGROUND AND PURPOSE: Usual interstitial pneumonia is a chronic pulmonary disease, and it is characterized by progressive and rapid lung fibrosis and typically affects patients older than 50 years. This study sought to discuss the use of chest expansion exercises during the immediate post-operative phase in a lung transplantation recipient. METHODS: This was a non-experimental case report study. A 58-year-old man who was affected by usual interstitial pneumonia with severe respiratory insufficiency requiring continuous oxygen therapy underwent double lung transplantation...
September 2015: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
https://www.readbyqxmd.com/read/25582243/a-successful-child-to-adult-deceased-donor-liver-transplantation-a-case-report-and-literature-review
#17
REVIEW
An-Chieh Feng, Chi-Yang Liao, Hsiu-Lung Fan, Teng-Wei Chen, Chung-Bao Hsieh
BACKGROUND: Size mismatch, which might result in small-for-size syndrome, is still a major limitation of liver transplantation. Prior data has suggested that a graft-to-recipient weight ratio <0.8% was a risk factor for developing small-for-size syndrome. CASE REPORT: We report the case of a 60-year-old woman who received a whole liver graft, with an estimated graft-to-recipient weight ratio of 0.46%, from a 10-year-old child donor weighing 12.8 kg pre-operatively...
2015: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/25455752/effect-of-infection-with-transmissible-strains-of-pseudomonas-aeruginosa-on-lung-transplantation-outcomes-in-patients-with-cystic-fibrosis
#18
COMPARATIVE STUDY
Nadim Srour, Cecilia Chaparro, Katherine Vandemheen, Lianne G Singer, Shaf Keshavjee, Shawn D Aaron
BACKGROUND: Compared with patients infected with unique strains of Pseudomonas aeruginosa, patients with cystic fibrosis who are infected with transmissible strains of P aeruginosa, such as the Liverpool epidemic strain, have a 3-fold greater risk of death or lung transplant. We aimed to determine if pre-operative infection with transmissible strains of P aeruginosa was similarly associated with poor health outcomes after lung transplant. METHODS: We had prospectively identified and characterized endobronchial infections in 446 adult cystic fibrosis patients in Ontario, Canada, from September 2005 until December 2009...
April 2015: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/25242800/successful-lung-salvage-by-ex%C3%A2-vivo-reconditioning-of-neurogenic-pulmonary-edema-case-report
#19
P G Sanchez, A T Iacono, K Rajagopal, B P Griffith
Liberalization in donor selection criteria allowed centers to increase the number of lung transplants, yet less than 25% of all donors had lungs utilized for transplantation in the United States in 2013. Less than 5% of all transplanted donors deviate 3 or more criteria from the ideal donor. Ex vivo lung perfusion (EVLP) provides the opportunity to increase the percentage of used donors by acting on modifiable selection criteria such as oxygenation, contusion and pulmonary infiltrates. We report the pre-transplant use of EVLP in the salvage of lungs from a donor that developed neurogenic pulmonary edema -PaO2 188 mmHg-...
September 2014: Transplantation Proceedings
https://www.readbyqxmd.com/read/25174332/managing-central-venous-obstruction-in-cystic-fibrosis-recipients-lung-transplant-considerations
#20
Shinji Otani, Glen P Westall, Bronwyn J Levvey, Silvana Marasco, Stuart Lyon, Gregory I Snell
BACKGROUND: The superior vena cava (SVC) syndrome in cystic fibrosis (CF) patients is rare, but presents unique challenges in the peri-transplant period. We reviewed our experience of SVC syndrome in CF recipients undergoing lung transplantation. METHODS: This is a retrospective case series from a single center chart-review. SVC obstruction is defined by clinically significant stenosis or obstruction of the SVC as detected by contrast studies. RESULTS: We identified SVC obstruction in seven post-transplant cases and one pre-transplant case...
March 2015: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
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