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Pre operative lung transplant

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https://www.readbyqxmd.com/read/29667786/frailty-phenotypes-and-mortality-after-lung-transplantation-a-prospective-cohort-study
#1
Jonathan P Singer, Joshua M Diamond, Michaela R Anderson, Patricia P Katz, Ken Covinsky, Michelle Oyster, Tatiana Blue, Allison Soong, Laurel Kalman, Pavan Shrestha, Selim M Arcasoy, John R Greenland, Lori Shah, Jasleen Kukreja, Nancy P Blumenthal, Imaani Easthausen, Jeffrey A Golden, Amika McBurnie, Ed Cantu, Joshua Sonett, Steven Hays, Hilary Robbins, Kashif Raza, Matthew Bacchetta, Rupal J Shah, Frank D'Ovidio, Aida Venado, Jason D Christie, David J Lederer
Frailty is associated with increased mortality among lung transplant candidates. We sought to determine the association between frailty, as measured by the Short Physical Performance Battery (SPPB) and mortality after lung transplantation. In a multicenter prospective cohort study of adults who underwent lung transplantation, pre-operative frailty was assessed with the SPPB (n=318) and, in a secondary analysis, the Fried Frailty Phenotype (FFP; n=299). We tested the association between pre-operative frailty and mortality following lung transplantation with propensity score adjusted Cox models...
April 18, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29661444/single-and-double-lung-transplantation-results-of-an-initial-experience-of-39-cases-in-cear%C3%A3-northeast-brazil
#2
A Gomes Neto, A S Monteiro Nogueira, I Lopes De Medeiros, R Fernandes Viana De Araujo, R Carvalho Santos, C M Sampaio Viana, F Moreira Batista Aguiar, L Gomes Catunda, L Araújo Aragão, R Fava Alencar
INTRODUCTION: The lung transplantation (LTx) program began in Ceará in 2011 and the first LTx was performed on June 11, 2011. The aim of this study was to present the initial results of the 6-year experience of our program. METHODS: We retrospectively reviewed our experience on LTx from June 2011 to August 2017. Data on recipients and transoperative and postoperative outcomes were recorded in a database. RESULTS: Twenty-two (56.4%) were single LTx, 15 (38...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29547626/clinical-management-and-outcomes-of-patients-with-hermansky-pudlak-syndrome-pulmonary-fibrosis-evaluated-for-lung-transplantation
#3
Souheil El-Chemaly, Kevin J O'Brien, Steven D Nathan, Gerald L Weinhouse, Hilary J Goldberg, Jean M Connors, Ye Cui, Todd L Astor, Philip C Camp, Ivan O Rosas, Merte Lemma, Vladislav Speransky, Melissa A Merideth, William A Gahl, Bernadette R Gochuico
Pulmonary fibrosis is a progressive, fatal manifestation of Hermansky-Pudlak syndrome (HPS). Some patients with advanced HPS pulmonary fibrosis undergo lung transplantation despite their disease-associated bleeding tendency; others die while awaiting donor organs. The objective of this study is to determine the clinical management and outcomes of a cohort with advanced HPS pulmonary fibrosis who were evaluated for lung transplantation. Six patients with HPS-1 pulmonary fibrosis were evaluated at the National Institutes of Health Clinical Center and one of two regional lung transplant centers...
2018: PloS One
https://www.readbyqxmd.com/read/29477456/incidence-risk-factors-and-clinical-implications-of-post-operative-delirium-in-lung-transplant-recipients
#4
Brian J Anderson, Christopher F Chesley, Miranda Theodore, Colin Christie, Ryan Tino, Alex Wysoczanski, Kristy Ramphal, Michelle Oyster, Laurel Kalman, Mary K Porteous, Christian A Bermudez, Edward Cantu, Dennis L Kolson, Jason D Christie, Joshua M Diamond
BACKGROUND: Delirium significantly affects post-operative outcomes, but the incidence, risk factors, and long-term impact of delirium in lung transplant recipients have not been well studied. METHODS: We analyzed 155 lung transplant recipients enrolled in the Lung Transplant Outcomes Group (LTOG) cohort at a single center. We determined delirium incidence by structured chart review, identified risk factors for delirium, determined whether plasma concentrations of 2 cerebral injury markers (neuron-specific enolase [NSE] and glial fibrillary acidic protein [GFAP]) were associated with delirium, and determined the association of post-operative delirium with 1-year survival...
February 2, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29276625/epicardial-delivery-of-autologous-atrial-appendage-micrografts-during-coronary-artery-bypass-surgery-safety-and-feasibility-study
#5
Annu Nummi, Tuomo Nieminen, Tommi Pätilä, Milla Lampinen, Miia L Lehtinen, Sari Kivistö, Miia Holmström, Erika Wilkman, Kari Teittinen, Mika Laine, Juha Sinisalo, Markku Kupari, Esko Kankuri, Tatu Juvonen, Antti Vento, Raili Suojaranta, Ari Harjula
Background: The atrial appendages are a tissue reservoir for cardiac stem cells. During on-pump coronary artery bypass graft (CABG) surgery, part of the right atrial appendage can be excised upon insertion of the right atrial cannula of the heart-lung machine. In the operating room, the removed tissue can be easily cut into micrografts for transplantation. This trial aims to assess the safety and feasibility of epicardial transplantation of atrial appendage micrografts in patients undergoing CABG surgery...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29190571/patterns-and-predictors-of-pain-following-lung-transplantation
#6
Julia M Farquhar, Patrick J Smith, Laurie Snyder, Alice L Gray, John M Reynolds, James A Blumenthal
OBJECTIVE: Our objective was to examine variability in pain levels following lung transplantation, and examine individual biopsychosocial factors influencing changes in pain. METHOD: We performed a retrospective study of a cohort of 150 patients transplanted and discharged from Duke University Hospital between January 2015 and September 2016. During hospitalization and at clinic visits up to two months after discharge, subjective pain ratings were obtained using a 0-10 Numeric Rating Scale...
January 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29188366/pre-operative-neutrophil-count-and-neutrophil-lymphocyte-count-ratio-nlcr-in-predicting-the-histological-grade-of-paediatric-brain-tumours-a-preliminary-study
#7
J R F Wilson, F Saeed, A K Tyagi, J R Goodden, G Sivakumar, D Crimmins, M Elliott, S Picton, P D Chumas
INTRODUCTION: The neutrophil-lymphocyte count ratio (NLCR) is an established prognostic marker for renal, lung and colorectal carcinomas and has been suggested to be predictive of histological grade and outcome in adult intracranial tumours. The purpose of this study was to determine whether a correlation of the pre-operative neutrophil count (NC) and NLCR with the final histological grade exists in paediatric intracranial tumours. METHODS: A retrospective analysis was undertaken at a single centre...
November 29, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29110797/pre-anaesthetic-evaluation-of-the-patient-with-end-stage-lung-disease
#8
REVIEW
Mahesh Prabhu, Kamen Valchanov
Lung transplantation is a viable alternative for end-stage lung diseases, which offers good quality of life and survival outcomes for recipients. The aims of pre-assessment for potential lung transplant recipients are to assess fitness for surgery, optimise co-morbidities, commence interventions or investigations, weigh risk-benefit ratio, plan appropriate analgesia and obtain informed consent. The assessment information is gathered from the medical record, patient interview, physical examination and pre-operative tests...
June 2017: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/29055604/treatment-of-primary-graft-dysfunction-after-lung-transplantation-with-orally-inhaled-ap301-a-prospective-randomized-pilot-study
#9
Clemens Aigner, Alexis Slama, Maximilian Barta, Andreas Mitterbauer, Gyoergy Lang, Shahrokh Taghavi, Jose Matilla, Roman Ullrich, Katharina Krenn, Peter Jaksch, Klaus Markstaller, Walter Klepetko
BACKGROUND: Primary graft dysfunction (PGD) after lung transplantation (LTx) carries significant morbidity and mortality in the early post-operative period and is associated with the development of chronic lung allograft dysfunction. AP301, an activator of epithelial sodium channel-mediated Na+ uptake represents a new concept for prevention and treatment of pulmonary edema and has shown promising results in the pre-clinical setting. This pilot study investigated the clinical effect of inhaled AP301 on patients with development of PGD > 1 according to International Society of Heart and Lung Transplantation criteria after primary LTx in a high-volume center and was conducted as a randomized, placebo-controlled, single-center pilot-study including 20 patients...
September 30, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28993607/liver-transplantation-for-high-risk-hepatocellular-carcinoma-after-liver-resection-a-sequential-or-salvage-approach
#10
Chih-Che Lin, Ahmed M Elsarawy, Wei-Feng Li, Ting-Lung Lin, Chee-Chien Yong, Shih-Ho Wang, Chih-Chi Wang, Fang-Ying Kuo, Yu-Fan Cheng, Chao-Long Chen
BACKGROUND Liver transplantation (LT) is the best radical treatment of hepatocellular carcinoma (HCC). Salvage liver transplantation (SalvLT) provides good outcomes for recurrent HCC cases after initial curative liver resection (LR). However, the salvage strategy is not feasible in all situations due to aggressive recurrences. Recently, sequential liver transplantation (SeqLT) was proposed for cases that show adverse pathological features after LR, thus LT is performed pre-emptively before recurrence. In this report, we compared the outcomes of SalvLT and SeqLT for surgical treatment of HCC...
October 10, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28972662/single-center-experience-in-urgent-lung-transplantation-program-in-a-country-with-a-shortage-of-donors-does-the-end-justify-the-means
#11
Marco Schiavon, Giulio Faggi, Guido Di Gregorio, Francesca Calabrese, Francesca Lunardi, Giuseppe Marulli, Paolo Feltracco, Monica Loy, Marco Damin, Emanuele Cozzi, Dario Gregori, Fiorella Calabrese, Federico Rea
In rapidly deteriorating patients awaiting lung transplantation (LT), supportive strategies are only temporary and urgent lung transplant (ULT) remains the last option. The few publications on this topic report conflicting results. According to the Italian national program, patients on mechanical ventilation and/or extracorporeal membrane oxygenation (ECMO) may be included in urgent list. We reviewed our experience from January 2012 to December 2014 with ULT and elective lung transplantation (ELT), focusing on outcomes...
December 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28508451/impact-of-left-ventricular-diastolic-dysfunction-on-lung-transplantation-outcome-in-patients-with-pulmonary-arterial-hypertension
#12
A Avriel, A H Klement, S R Johnson, M de Perrot, J Granton
Diastolic dysfunction may influence perioperative outcome, early graft function, and long-term survival. We compared the outcomes of double lung transplantation (DLTx) for patients with pulmonary arterial hypertension (PAH) with preoperative left ventricular (LV) diastolic dysfunction with the outcomes of patients without diastolic dysfunction. Of 116 consecutive patients with PAH (who underwent transplantation between January 1995 and December 2013), 44 met our inclusion and exclusion criteria. Fourteen (31...
October 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28280698/lobar-lung-transplantation-from-deceased-donors-a-systematic-review
#13
Michael Eberlein, Robert M Reed, Mayy Chahla, Servet Bolukbas, Amy Blevins, Dirk Van Raemdonck, Alessia Stanzi, Ilhan Inci, Silvana Marasco, Norihisa Shigemura, Clemens Aigner, Tobias Deuse
AIM: To systematically review reports on deceased-donor-lobar lung transplantation (ddLLTx) and uniformly describe size matching using the donor-to-recipient predicted-total lung-capacity (pTLC) ratio. METHODS: We set out to systematically review reports on ddLLTx and uniformly describe size matching using the donor-to-recipient pTLC ratio and to summarize reported one-year survival data of ddLLTx and conventional-LTx. We searched in PubMed, CINAHL via EBSCO, Cochrane Database of Systematic Reviews via Wiley (CDSR), Database of Abstracts of Reviews of Effects via Wiley (DARE), Cochrane Central Register of Controlled Trials via Wiley (CENTRAL), Scopus (which includes EMBASE abstracts), and Web of Science for original reports on ddLLTx...
February 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/28242867/living-donor-liver-transplantation-for-combined-hepatocellular-carcinoma-and-cholangiocarcinoma-experience-of-a-single-center
#14
Cheng-Chih Chang, Ying-Ju Chen, Tzu-Hao Huang, Chun-Han Chen, Fang-Ying Kuo, Hock-Liew Eng, Chee-Chien Yong, Yueh-Wei Liu, Ting-Lung Lin, Wei-Feng Li, Yu-Hung Lin, Chih-Che Lin, Chih-Chi Wang, Chao-Long Chen
BACKGROUND Because the outcome of liver transplantation for cholangiocarcinoma is often poor, cholangiocarcinoma is a contraindication for liver transplantation in most centers. Combined hepatocellular carcinoma and cholangiocarcinoma is a rare type of primary hepatic malignancy containing features of hepatocellular carcinoma and cholangiocarcinoma. Diagnosing combined hepatocellular carcinoma and cholangiocarcinoma pre-operatively is difficult. Because of sparse research presentations worldwide, we report our experience with living donor liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma...
February 28, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28095640/irradiation-before-and-donor-splenocyte-infusion-immediately-after-transplantation-induce-tolerance-to-lung-but-not-heart-allografts-in-miniature-swine
#15
Wiebke Sommer, Gwen Buechler, Katharina Jansson, Murat Avsar, Ann-Kathrin Knöfel, Jawad Salman, Klaus Hoeffler, Thierry Siemeni, Jens Gottlieb, Johann H Karstens, Danny Jonigk, Ansgar Reising, Axel Haverich, Martin Strüber, Gregor Warnecke
Solid organs may differ in their potential to induce and maintain a state of donor-specific tolerance. Previously, we induced stable immunological tolerance in a lung transplantation model in miniature swine. Here, we wished to transfer this established protocol into a heart transplantation model in miniature swine. Heterotopic heart transplantation (HTX) was performed in four and left-sided lung transplantation (LTX) in seven minipigs from gender- and SLA-mismatched donors. All recipients received nonmyeloablative irradiation, donor splenocyte infusion and intravenous pharmacologic immunosuppression for 28 postoperative days...
April 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28086849/successful-outcome-following-pneumonectomy-in-a-teenage-boy-with-cystic-fibrosis-a-case-report
#16
Zheyi Liew, Santosh Mallikarjuna, Asif Hasan, F Kate Gould, Su Bunn, Matthew F Thomas, Jim L Lordan, Christopher O'Brien, Malcolm Brodlie
BACKGROUND: Cystic fibrosis lung disease is generally a diffuse process however rarely one lung may become particularly damaged through chronic collapse and consolidation resulting in end-stage bronchiectasis with relative sparing of the contralateral lung. This clinical situation is sometimes referred to as "destroyed lung". Lung resection surgery is seldom indicated in cystic fibrosis and the associated medical literature is relatively sparse. CASE PRESENTATION: A 14 year old boy was referred to our centre for lung transplantation assessment...
January 13, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27569957/severe-sepsis-after-living-donor-liver-transplantation-risk-factors-and-outcomes
#17
K Takeda, Y Sawada, T Kumamoto, K Tanaka, I Endo
BACKGROUND: The post-operative mortality and morbidity rates associated with living-donor liver transplantation (LDLT) are still relatively high. Several papers have reported the risk factors associated with post-operative infectious complications, but few have analyzed the risk factors with respect to the severity of sepsis. The aim of this study was to clarify the risk factors that affect severe sepsis after LDLT. METHODS: For 63 LDLT patients at our institute, we compared peri-operative characteristics in 29 patients who developed sepsis after surgery and 34 patients who did not...
July 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27548238/physical-activity-and-exertional-desaturation-are-associated-with-mortality-in-idiopathic-pulmonary-fibrosis
#18
Baruch Vainshelboim, Mordechai Reuven Kramer, Shimon Izhakian, Ricardo M Lima, Jose Oliveira
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that manifests in hypoxemia, inactivity, and poor prognosis. This study aimed to assess the prognostic role of physical activity (PA) and exertional desaturation (ED) with mortality in IPF. At baseline, 34 IPF patients (68 (50-81) years) were interviewed using the International Physical Activity Questionnaire (IPAQ), and SpO₂ was assessed pre to post 6-min walking test (∆SpO₂). Patients were prospectively followed up for 40 months. Receiver operating characteristics curve analysis determined cut-off points associated with mortality, and Cox proportional hazard ratio (HR) were conducted...
August 18, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27367568/parametric-response-mapping-of-bronchiolitis-obliterans-syndrome-progression-after-lung-transplantation
#19
S E Verleden, R Vos, E Vandermeulen, D Ruttens, H Bellon, T Heigl, D E Van Raemdonck, G M Verleden, V Lama, B D Ross, C J Galbán, B M Vanaudenaerde
Bronchiolitis obliterans syndrome (BOS) remains a major complication after lung transplantation. Air trapping and mosaic attenuation are typical radiological features of BOS; however, quantitative evaluation remains troublesome. We evaluated parametric response mapping (PRM, voxel-to-voxel comparison of inspiratory and expiratory computed tomography [CT] scans) in lung transplant recipients diagnosed with BOS (n = 20) and time-matched stable lung transplant recipients (n = 20). Serial PRM measurements were performed prediagnosis, at time of BOS diagnosis, and postdiagnosis (Tpre , T0 , and Tpost , respectively), or at a postoperatively matched time in stable patients...
November 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27266805/how-important-is-coronary-artery-disease-when-considering-lung-transplant-candidates
#20
Marijan Koprivanac, Marie M Budev, James J Yun, Marta Kelava, Gösta B Pettersson, Kenneth R McCurry, Douglas R Johnston, Abeel A Mangi, Penny L Houghtaling, Eugene H Blackstone, Sudish C Murthy
BACKGROUND: Coronary artery disease (CAD) remains a relative contraindication for lung transplantation, but should it be if amenable to effective palliation? METHODS: From January 2005 to July 2010, 356 adults undergoing primary lung transplantation had no significant (<50%) coronary arterial stenosis and 70 had significant (≥50%) CAD requiring prior or concomitant revascularization. Propensity matching on 38 pre-transplant patient characteristics identified 61 well-matched pairs (87% of possible matches) and 295 no-CAD unmatched patients to compare post-operative morbidity, graft function, and time-related pulmonary function and survival...
December 2016: Journal of Heart and Lung Transplantation
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