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Non resolving pneumonia

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https://www.readbyqxmd.com/read/29113006/transjugular-portal-vein-recanalization-with-creation-of-intrahepatic-portosystemic-shunt-pvr-tips-in-patients-with-chronic-non-cirrhotic-non-malignant-portal-vein-thrombosis
#1
Christoph Klinger, Bettina Riecken, Arthur Schmidt, Andrea De Gottardi, Benjamin Meier, Jaime Bosch, Karel Caca
Purpose To determine safety and efficacy of transjugular portal vein recanalization with creation of intrahepatic portosystemic shunt (PVR-TIPS) in patients with chronic non-cirrhotic, non-malignant portal vein thrombosis (PVT). Methods This retrospective study includes 17 consecutive patients with chronic non-cirrhotic PVT (cavernous transformation n = 15). PVR-TIPS was indicated because of variceal bleeding (n = 13), refractory ascites (n = 2), portal biliopathy with recurrent cholangitis (n = 1), or abdominal pain (n = 1)...
November 7, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29038764/pulmonary-transcriptomic-responses-indicate-a-dual-role-of-inflammation-in-pneumonia-development-and-viral-clearance-during-2009-pandemic-influenza-infection
#2
Raquel Almansa, Pamela Martínez-Orellana, Lucía Rico, Verónica Iglesias, Alicia Ortega, Beatriz Vidaña, Jorge Martínez, Ana Expósito, María Montoya, Jesús F Bermejo-Martin
BACKGROUND: The interaction between influenza virus and the host response to infection clearly plays an important role in determining the outcome of infection. While much is known on the participation of inflammation on the pathogenesis of severe A (H1N1) pandemic 09-influenza virus, its role in the course of non-fatal pneumonia has not been fully addressed. METHODS: A systems biology approach was used to define gene expression profiles, histology and viral dynamics in the lungs of healthy immune-competent mice with pneumonia caused by a human influenza A (H1N1) pdm09 virus, which successfully resolved the infection...
2017: PeerJ
https://www.readbyqxmd.com/read/28871587/primary-pulmonary-malt-lymphoma-presenting-as-non-resolving-pneumonia
#3
Asma Iftikhar, Albert Magh, Muhammed Azaz Cheema, Sarah Thappa, Sonu Sahni, Stephen Karbowitz
Primary lung lymphoma (PLL) is a rare unilateral or bilateral lung disorder that is challenging to diagnose solely based on clinical and radiological presentation. PLL may be misdiagnosed as pneumonia or a lung tumor due to non-specific findings. PLL is most frequently a mucosa-associated lymphoid tissue (MALT) lymphoma, a type of extranodal low-grade B-cell lymphoma most commonly discovered in the gastrointestinal tract. PLL should be considered in the differential diagnosis of non-resolving pneumonias. Herein we present a case of an 84-year-old patient discovered to have a primary pulmonary MALT lymphoma presenting as a non-resolving pneumonia causing a clinical challenge...
2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/28744709/is-it-useful-to-look-into-airways-in-non-resolving-pneumonia
#4
REVIEW
Kana Ram Jat, S K Kabra
No abstract text is available yet for this article.
September 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28696635/-how-to-handle-a-non-resolving-pneumonia
#5
Benoit Lechartier, Maura Prella, Oriol Manuel, Laurent P Nicod
Persistent pneumonias are frequent both in hospital and primary care settings. Several parameters have to be taken into account. Firstly the appropriateness of treatment; secondly the immune status of the host; and finally infectious complications need to be ruled out. Several non-infectious diagnoses can mimic a persistent infiltrate, such as neoplastic disorders, organising pneumonias, interstitial disorders and drug - or radiation-induced lung diseases. Uncommon pathogens will not respond to common treatment, for instance atypical bacteria, mycobacteria, fungi including Pneumocystis as well as viruses...
November 16, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28557369/medical-mishap-as-a-cause-of-non-resolving-pneumonia
#6
Yazeed Toukan, Michal Gur, Vered Nir, Lea Bentur
A 15-year old boy was referred for evaluation of fever, productive cough, and recurrent/persistent right lower lobe (RLL) pneumonia of 1-month duration. Chest computed tomography scan showed RLL consolidation, with minimal pleural effusion and a liver abscess with sharp borders, containing a solid calcification in the lower portion. History revealed acute appendicitis with laparoscopic appendectomy 6 months prior to presentation, during which a fecalith dropped to the peritoneal cavity. Following laparoscopically guided drainage of the abscess the patient improved...
May 30, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28534218/flexible-bronchoscopy-in-non-resolving-pneumonia
#7
Javeed Iqbal Bhat, Wasim Ahmad Wani, Qazi Iqbal Ahmad, Bashir Ahmad Charoo, Syed Wajid Ali, Ambreen Ali Ahangar, Muzafar Ahmad
OBJECTIVE: To study the utility of diagnostic flexible bronchoscopy and bronchoalveolar lavage (BAL) in children with non-resolving pneumonia. METHODS: This was a cross-sectional study conducted in a tertiary care hospital from July 2015 through June 2016. Fifty-two consecutive children of both genders from 1 mo to 14 y of age with a diagnosis of non-resolving pneumonia were included. Flexible bronchoscopy was done in all patients with or without bronchoalveolar lavage (BAL)...
September 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28502784/liposome-loaded-phage-cocktail-enhanced-therapeutic-potential-in-resolving-klebsiella-pneumoniae-mediated-burn-wound-infections
#8
Parul Chadha, Om Prakash Katare, Sanjay Chhibber
BACKGROUND: Klebsiella pneumoniae is one of the predominant pathogens in burn wound infections, and prevalence of multidrug resistant strains has further complicated the situation. An increased interest in phage therapy as a means of combating infection has been accruing in recent years. In order to overcome the drawbacks associated with phage therapy, the present study was conducted to evaluate the potential of liposomes as a delivery vehicle for phage in the treatment of burn wound infection...
November 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28422188/resolvin-d1-enhances-the-resolution-of-lung-inflammation-caused-by-long-term-pseudomonas-aeruginosa-infection
#9
M Codagnone, E Cianci, A Lamolinara, V C Mari, A Nespoli, E Isopi, D Mattoscio, M Arita, A Bragonzi, M Iezzi, M Romano, A Recchiuti
Pseudomonas aeruginosa lung infection is a main cause of disability and mortality worldwide. Acute inflammation and its timely resolution are crucial for ensuring bacterial clearance and limiting tissue damage. Here, we investigated protective actions of resolvin (Rv) D1 in lung infection induced by the RP73 clinical strain of P. aeruginosa. RvD1 significantly diminished bacterial growth and neutrophil infiltration during acute pneumonia caused by RP73. Inoculum of RP73, immobilized in agar beads, resulted in persistent lung infection up to 21 days, leading to a non resolving inflammation reminiscent of human pathology...
April 19, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28377567/chronic-granulomatous-disease-presenting-as-aspergillus-fumigatus-pneumonia-in-a-previously-healthy-young-woman
#10
David Williams, Dipen Kadaria, Amik Sodhi, Roy Fox, Glenn Williams, Stephen Threlkeld
BACKGROUND Chronic Granulomatous Disease (CGD) is a rare immunodeficiency disease caused by a genetic defect in the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase enzyme, resulting in increased susceptibility to bacterial and fungal infections. The inheritance can be X-linked or autosomal recessive. Patients usually present with repeated infections early in life. We present an unusual case of a 23-year-old patient diagnosed with CGD. CASE REPORT A 23-year-old white woman with no previous history of recurrent infections presented with complaints of fever, shortness of breath, and diffuse myalgia...
April 5, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28275024/levetiracetam-induced-eosinophilic-pneumonia
#11
Aisling Fagan, Jonathan Fuld, Elaine Soon
Levetiracetam is widely regarded as a benign antiepileptic drug, compared to older antiepileptic medication. We report a case of eosinophilic pneumonia due to levetiracetam use in a non-smoking woman aged 59 years with no previous respiratory history. Our patient presented with exertional breathlessness and marked desaturation on exertion. She displayed 'reverse bat-wing' infiltrates on her chest radiograph and peripheral eosinophilia on a complete blood count. Her symptoms, radiology and peripheral eosinophilia resolved completely with cessation of levetiracetam and a course of prednisolone...
March 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28212992/nivolumab-induced-interstitial-lung-disease-analysis-of-two-phase-ii-studies-patients-with-recurrent-or-advanced-non-small-cell-lung-cancer
#12
MULTICENTER STUDY
Terufumi Kato, Noriyuki Masuda, Yoichi Nakanishi, Masashi Takahashi, Toyoaki Hida, Hiroshi Sakai, Shinji Atagi, Shiro Fujita, Hiroshi Tanaka, Koji Takeda, Miyako Satouchi, Yoshinobu Namba, Tomohide Tamura
OBJECTIVES: Drug-induced interstitial lung disease (ILD) is often associated with high mortality; however it is difficult to predict and manage. we examined the clinical findings and imaging characteristics of nivolumab induced ILD reported in the two phase II studies patients with recurrent or advanced non-small-cell lung cancer. MATERIALS AND METHODS: We examined the clinical findings and imaging characteristics of all cases of ILD reported in two phase II trials of nivolumab, an anti-programmed death-1 antibody, in Japanese patients with recurrent or advanced non-small-cell lung cancer...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28122542/universal-versus-conditional-three-day-follow-up-visit-for-children-with-uncomplicated-fever-at-the-community-level-design-of-a-cluster-randomized-community-based-non-inferiority-trial-in-tanganyika-democratic-republic-of-congo
#13
Elburg van Boetzelaer, Lara S Ho, Julie R Gutman, Laura C Steinhardt, Alison Wittcoff, Yolanda Barbera, Pascal Ngoy, Steven A Harvey, Luke C Mullany
BACKGROUND: The current recommendation within integrated Community Case Management guidelines that all children presenting with uncomplicated fever and no danger signs be followed up after three days may not be necessary. Such fevers often resolve rapidly (usually within 48-96 h), and previous studies suggest that expectant home care for uncomplicated fever can be safely recommended. We aim to determine the non-inferiority of a conditional versus a universal follow-up visit for these children...
January 26, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28063015/innate-immunity-against-legionella-pneumophila-during-pulmonary-infections-in-mice
#14
REVIEW
Bonggoo Park, Gayoung Park, Jiyoung Kim, Seon Ah Lim, Kyung-Mi Lee
Legionella pneumophila is an etiological agent of the severe pneumonia known as Legionnaires' disease (LD). This gram-negative bacterium is thought to replicate naturally in various freshwater amoebae, but also replicates in human alveolar macrophages. Inside host cells, legionella induce the production of non-endosomal replicative phagosomes by injecting effector proteins into the cytosol. Innate immune responses are first line defenses against legionella during early phases of infection, and distinguish between legionella and host cells using germline-encoded pattern recognition receptors such as Toll-like receptors , NOD-like receptors, and RIG-I-like receptors, which sense pathogen-associated molecular patterns that are absent in host cells...
February 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27987042/using-dendritic-cells-to-evaluate-how-burkholderia-cenocepacia-clonal-isolates-from-a-chronically-infected-cystic-fibrosis-patient-subvert-immune-functions
#15
M Guadalupe Cabral, Marília Pereira, Zélia Silva, Inês Iria, Carla Coutinho, Andreia Lopes, Isabel Sá-Correia, Paula A Videira
Infection with Burkholderia cepacia complex (Bcc) bacteria is a threat to cystic fibrosis (CF) patients, commonly leading to a fatal pneumonia, the cepacia syndrome. It causes a massive production of pro-inflammatory cytokines and leucocyte recruitment to airway epithelium without resolving infection and contributing to tissue lesion. To dissect how Bcc bacteria subvert the immune response, we developed a co-culture model with human dendritic cells (DCs) and B. cenocepacia clonal variants isolated from a chronically infected CF patient, who died with cepacia syndrome...
April 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/27909995/solithromycin-a-novel-fluoroketolide-for-the-treatment-of-community-acquired-bacterial-pneumonia
#16
REVIEW
George G Zhanel, Erika Hartel, Heather Adam, Sheryl Zelenitsky, Michael A Zhanel, Alyssa Golden, Frank Schweizer, Bala Gorityala, Philippe R S Lagacé-Wiens, Andrew J Walkty, Alfred S Gin, Daryl J Hoban, Joseph P Lynch, James A Karlowsky
Solithromycin is a novel fluoroketolide developed in both oral and intravenous formulations to address increasing macrolide resistance in pathogens causing community-acquired bacterial pneumonia (CABP). When compared with its macrolide and ketolide predecessors, solithromycin has several structural modifications which increase its ribosomal binding and reduce its propensity to known macrolide resistance mechanisms. Solithromycin, like telithromycin, affects 50S ribosomal subunit formation and function, as well as causing frame-shift errors during translation...
December 2016: Drugs
https://www.readbyqxmd.com/read/27858147/evolution-and-function-of-the-mycoplasma-hyopneumoniae-peroxiredoxin-a-2-cys-like-enzyme-with-a-single-cys-residue
#17
Taylor Gonchoroski, Veridiana G Virginio, Claudia E Thompson, Jéssica A Paes, Cláudio X Machado, Henrique B Ferreira
The minimal genome of the mollicute Mycoplasma hyopneumoniae, the etiological agent of porcine enzootic pneumonia, encodes a limited repertoire of antioxidant enzymes that include a single and atypical peroxiredoxin (MhPrx), whose evolution and function were studied here. MhPrx has only one catalytic cysteine, in contrast with some of its possible ancestors (2-Cys peroxiredoxins), which have two. Although it is more similar to 2-Cys orthologs, MhPrx can still function with a single peroxidatic cysteine (CysP), using non-thiolic electron donors to reduce it...
April 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/27790283/pulmonary-leukocytoclastic-vasculitis-as-an-initial-presentation-of-myelodysplastic-syndrome
#18
Seung Hyun Lee, Jae Hyung Kim, Sejin Park, Chang Youn Won, Joo-Hyun Lee, Seong Yoon Yi, Hye Kyeong Park, Sun Hee Chang, Hoon Jung, Sung-Soon Lee, Hyeon-Kyoung Koo
Systemic vasculitis involving the lung is a rare manifestation of myelodysplastic syndrome (MDS), and secondary vasculitis is considered to have poor prognosis. A 44-year-old man presented with fever and dyspnea of 1 month duration. A chest radiograph revealed bilateral multiple wedge shaped consolidations. In addition, the results of a percutaneous needle biopsy for non-resolving pneumonia were compatible with pulmonary vasculitis. Bone marrow biopsy was performed due to the persistence of unexplained anemia and the patient was diagnosed with MDS...
October 2016: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27773849/intranasal-administration-of-a-polyvalent-bacterial-lysate-induces-self-restricted-inflammation-in-the-lungs-and-a-th1-th17-memory-signature
#19
Analía Rial, Florencia Ferrara, Norma Suárez, Paola Scavone, Juan Martín Marqués, José Alejandro Chabalgoity
Respiratory tract infections are among the most frequent infections in humans causing millions of deaths especially in children and the elderly. Antibiotics and vaccines are the main available tools of control, but resistant strains are continuously arising and available vaccines only account for few of many pathogens involved. Non-specific immunotherapies are an emerging alternative to induce protective immunity at the airways. Mucosally administered polyvalent bacterial lysates (PBLs) have been widely used for decades for prevention of respiratory diseases, but the bases of their proposed therapeutic effectiveness are still controversial...
December 2016: Microbes and Infection
https://www.readbyqxmd.com/read/27704258/radial-ultrasound-assisted-transbronchial-biopsy-a-new-diagnostic-approach-for-non-resolving-pulmonary-infiltrates-in-neutropenic-hemato-oncological-patients
#20
Maurizio Bernasconi, Alessio Casutt, Angela Koutsokera, Igor Letovanec, Frédéric Tissot, Laurent P Nicod, Alban Lovis
The role of radial-endobronchial ultrasound (R-EBUS) assisted transbronchial biopsy (TBB) for the diagnosis of peripheral pulmonary lesions is well established. However, no study has addressed its safety and value in hemato-oncological patients presenting with non-resolving infiltrates during persistent febrile neutropenia. To assess safety and feasibility of R-EBUS assisted TBB in severe thrombocytopenic and neutropenic patients. Over a period of 18 months, eight patients were assessed with R-EBUS assisted TBB after adequate platelet transfusion...
December 2016: Lung
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