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https://www.readbyqxmd.com/read/29145615/iptmnet-an-integrated-resource-for-protein-post-translational-modification-network-discovery
#1
Hongzhan Huang, Cecilia N Arighi, Karen E Ross, Jia Ren, Gang Li, Sheng-Chih Chen, Qinghua Wang, Julie Cowart, K Vijay-Shanker, Cathy H Wu
Protein post-translational modifications (PTMs) play a pivotal role in numerous biological processes by modulating regulation of protein function. We have developed iPTMnet (http://proteininformationresource.org/iPTMnet) for PTM knowledge discovery, employing an integrative bioinformatics approach-combining text mining, data mining, and ontological representation to capture rich PTM information, including PTM enzyme-substrate-site relationships, PTM-specific protein-protein interactions (PPIs) and PTM conservation across species...
November 14, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29145202/exploring-the-association-between-statin-use-and-the-risk-of-parkinson-s-disease-a-meta-analysis-of-observational-studies
#2
Tahmina Nasrin Poly, Md Mohaimenul Islam, Bruno Andreas Walther, Hsuan-Chia Yang, Phung-Anh Nguyen, Chih-Wei Huang, Syed-Abdul Shabbir, Yu-Chuan Jack Li
BACKGROUND: Parkinson's disease (PD) is a progressive disorder of the central nervous system. The prevalence of PD varies considerably by age group; it has a higher prevalence in patients aged 60 years and more. Several studies have shown that statin, a cholesterol-lowering medication, reduces the risk of developing PD, but evidence for this is so far inconclusive. The objective of this study is to evaluate the association between statin use and the risk of developing PD. METHODS: PubMed, EMBASE, and the bibliographies of articles were searched for studies published between January 1, 1990, and January 1, 2017, which reported on the association between statin use and PD...
November 16, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29142326/complex-organic-molecules-in-strongly-uv-irradiated-gas
#3
S Cuadrado, J R Goicoechea, J Cernicharo, A Fuente, J Pety, B Tercero
We investigate the presence of complex organic molecules (COMs) in strongly UV-irradiated interstellar molecular gas. We have carried out a complete millimetre (mm) line survey using the IRAM 30 m telescope towards the edge of the Orion Bar photodissociation region (PDR), close to the H2 dissociation front, a position irradiated by a very intense far-UV (FUV) radiation field. These observations have been complemented with 8.5″ resolution maps of the H2CO JKa,Kc = 51,5 → 41,4 and C(18)O J = 3 → 2 emission at 0...
July 2017: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/29141838/online-perceptions-of-mothers-about-breastfeeding-and-introducing-formula-qualitative-study
#4
Anna Lena Wennberg, Sanna Jonsson, Josefine Zadik Janke, Åsa Hörnsten
BACKGROUND: Although the benefits of breastfeeding are well established for babies and their mothers, many women give formula to their infants. Whether to breastfeed or to give infant formula is a complex decision to make. Many parents use the Internet to find information and support that relate to infant feeding decisions. OBJECTIVE: The aim of this study was to analyze the perceptions of mothers, who are discussing the topic on Web forums, about introducing infant formula...
November 15, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29141664/prevalence-and-prognosis-of-acutely-ill-patients-with-organ-failure-at-arrival-to-hospital-protocol-for-a-systematic-review
#5
Peter Bank Pedersen, Asbjorn Hrobjartsson, Daniel Lykke Nielsen, Daniel Pilsgaard Henriksen, Mikkel Brabrand, Annmarie Touborg Lassen
BACKGROUND: Acutely ill patients are a heterogeneous group, and some of these suffer from organ failure. As the prognosis of organ failure improves with early treatment, it is important to identify these patients as early as possible. Most studies on organ failure have been performed in intensive care settings, or on selected groups of patients, where a high prevalence and mortality have been reported. Before patients arrive to the intensive care unit, or the general ward, most of them have passed through the emergency department (ED), where diagnosis and treatment has been initiated...
November 15, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29140620/how-agricultural-media-cover-safety-compared-with-periodicals-in-two-other-hazardous-industries
#6
Amanda Marolf, Scott Heiberger, James Evans, Lura Joseph
This analysis featured a uniquely broad look at challenges and potentials for engaging agricultural and other industrial media more effectively in covering safety. It involved a content analysis of selected industry periodicals serving agriculture, mining, and transportation, which are three of the nation's most hazardous industries, in terms of human safety. Use of the social amplification of risk framework (SARF) provided insight on safety coverage. In particular, it tested previous research indicating that media coverage tends to amplify (increase) more than attenuate (decrease) a sense of risk...
January 26, 2017: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29138133/effects-of-weight-loss-interventions-for-adults-who-are-obese-on-mortality-cardiovascular-disease-and-cancer-systematic-review-and-meta-analysis
#7
Chenhan Ma, Alison Avenell, Mark Bolland, Jemma Hudson, Fiona Stewart, Clare Robertson, Pawana Sharma, Cynthia Fraser, Graeme MacLennan
Objective To assess whether weight loss interventions for adults with obesity affect all cause, cardiovascular, and cancer mortality, cardiovascular disease, cancer, and body weight.Design Systematic review and meta-analysis of randomised controlled trials (RCTs) using random effects, estimating risk ratios, and mean differences. Heterogeneity investigated using Cochran's Q and I(2) statistics. Quality of evidence assessed by GRADE criteria.Data sources Medline, Embase, the Cochrane Central Register of Controlled Trials, and full texts in our trials' registry for data not evident in databases...
November 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29137857/matricellular-proteins-and-survival-in-patients-with-pancreatic-cancer-a-systematic-review
#8
REVIEW
Sirio Fiorino, Maria Letizia Bacchi-Reggiani, Chiara Birtolo, Giorgia Acquaviva, Michela Visani, Adele Fornelli, Michele Masetti, Andrea Tura, Stefano Sbrignadello, Fabio Grizzi, Federica Patrinicola, Matteo Zanello, Laura Mastrangelo, Raffaele Lombardi, Claudia Benini, Luca Di Tommaso, Arrigo Bondi, Francesco Monetti, Elena Siopis, Paolo Emilio Orlandi, Michele Imbriani, Carlo Fabbri, Silvia Giovanelli, Andrea Domanico, Esterita Accogli, Salomone Di Saverio, Daniela Grifoni, Vincenzo Cennamo, Paolo Leandri, Elio Jovine, Dario de Biase
Extracellular matrix (ECM) plays a fundamental role in tissue architecture and homeostasis and modulates cell functions through a complex interaction between cell surface receptors, hormones, several bioeffector molecules, and structural proteins like collagen. These components are secreted into ECM and all together contribute to regulate several cellular activities including differentiation, apoptosis, proliferation, and migration. The so-called "matricellular" proteins (MPs) have recently emerged as important regulators of ECM functions...
November 4, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29137852/dysarthria-in-pallidal-deep-brain-stimulation-in-dystonia-depends-on-the-posterior-location-of-active-electrode-contacts-a-pilot-study
#9
K A M Pauls, P J Bröckelmann, S Hammesfahr, J Becker, A Hellerbach, V Visser-Vandewalle, T A Dembek, I G Meister, L Timmermann
BACKGROUND: Pallidal Deep Brain Stimulation (GPi-DBS) is an efficient treatment for primary dystonia. We investigated stimulation-induced dysarthria, which is the most frequent side-effect of GPi-DBS. METHODS: Speech was recorded while reading a standard text, and performing rapid syllable repetitions ON and OFF DBS in ten dystonia patients (6 men; 3 cervical, 4 segmental, 3 generalized, unselected for DBS-related speech impairments). Speech and articulation rate, pauses, and syllable repetition rates were extracted via acoustic analysis...
November 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29137493/tolerance-in-internet-gaming-disorder-a-need-for-increasing-gaming-time-or-something-else
#10
Daniel L King, Madeleine C E Herd, Paul H Delfabbro
Background and aims The criterion of tolerance in DSM-5 Internet gaming disorder (IGD) refers to a need for increasing time spent gaming. However, this focus on "need for gaming time" may overlook some of the broader motivations, outcomes, or effects of gaming that underlie excessive play. This study aimed to explore regular and problematic gamers' experiences and perceptions of tolerance in IGD. Methods An online survey of 630 adult gamers yielded 1,417 text responses to open-ended questions. A thematic analysis of 23,373 words was conducted to extract dominant themes...
November 15, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29137057/readability-of-internet-sourced-patient-education-material-related-to-labour-analgesia
#11
Nilay Boztas, Dilek Omur, Sule Ozbılgın, Gözde Altuntas, Ersan Piskin, Sevda Ozkardesler, Volkan Hanci
We evaluated the readability of Internet-sourced patient education materials (PEMs) related to "labour analgesia." In addition to assessing the readability of websites, we aimed to compare commercial, personal, and academic websites.We used the most popular search engine (http://www.google.com) in our study. The first 100 websites in English that resulted from a search for the key words "labour analgesia" were scanned. Websites that were not in English, graphs, pictures, videos, tables, figures and list formats in the text, all punctuation, the number of words in the text is less than 100 words, feedback forms not related to education, (Uniform Resource Locator) URL websites, author information, references, legal disclaimers, and addresses and telephone numbers were excluded...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29134191/assessing-treatment-response-in-triple-negative-breast-cancer-from-quantitative-image-analysis-in-perfusion-magnetic-resonance-imaging
#12
Imon Banerjee, Sadhika Malladi, Daniela Lee, Adrien Depeursinge, Melinda Telli, Jafi Lipson, Daniel Golden, Daniel L Rubin
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is sensitive but not specific to determining treatment response in early stage triple-negative breast cancer (TNBC) patients. We propose an efficient computerized technique for assessing treatment response, specifically the residual tumor (RT) status and pathological complete response (pCR), in response to neoadjuvant chemotherapy. The proposed approach is based on Riesz wavelet analysis of pharmacokinetic maps derived from noninvasive DCE-MRI scans, obtained before and after treatment...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29134188/simulation-study-of-quantitative-precision-of-the-pet-x-dedicated-breast-pet-scanner
#13
Chengeng Zeng, Paul E Kinahan, Hua Qian, Robert L Harrison, Kyle M Champley, Lawrence R MacDonald
The goal for positron emission tomography (PET)/X is measuring changes in radiotracer uptake for early assessment of response to breast cancer therapy. Upper bounds for detecting such changes were investigated using simulation and two image reconstruction algorithms customized to the PET/X rectangular geometry. Analytical reconstruction was used to study spatial resolution, comparing results with the distance of the closest approach (DCA) resolution surrogate that is independent of the reconstruction method...
October 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29134146/indicators-for-the-use-of-robotic-labs-in-basic-biomedical-research-a-literature-analysis
#14
Paul Groth, Jessica Cox
Robotic labs, in which experiments are carried out entirely by robots, have the potential to provide a reproducible and transparent foundation for performing basic biomedical laboratory experiments. In this article, we investigate whether these labs could be applicable in current experimental practice. We do this by text mining 1,628 papers for occurrences of methods that are supported by commercial robotic labs. Using two different concept recognition tools, we find that 86%-89% of the papers have at least one of these methods...
2017: PeerJ
https://www.readbyqxmd.com/read/29134067/modelling-the-role-of-correctional-services-on-gangs-insights-through-a-mathematical-model
#15
F Nyabadza, C P Ogbogbo, J Mushanyu
Research has shown that gang membership increases the chances of offending, antisocial behaviour and drug use. Gang membership should be acknowledged as part of crime prevention and policy designs, and when developing interventions and preventative programmes. Correctional services are designed to rehabilitate convicted offenders. We formulate a deterministic mathematical model using nonlinear ordinary differential equations to investigate the role of correctional services on the dynamics of gangs. The recruitment into gang membership is assumed to happen through an imitation process...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29133334/national-citation-patterns-of-nejm-the-lancet-jama-and-the-bmj-in-the-lay-press-a-quantitative-content-analysis
#16
Gonzalo Casino, Roser Rius, Erik Cobo
OBJECTIVES: To analyse the total number of newspaper articles citing the four leading general medical journals and to describe national citation patterns. DESIGN: Quantitative content analysis. SETTING/SAMPLE: Full text of 22 general newspapers in 14 countries over the period 2008-2015, collected from LexisNexis. The 14 countries have been categorised into four regions: the USA, the UK, Western World (European countries other than the UK, and Australia, New Zealand and Canada) and Rest of the World (other countries)...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29133332/built-to-last-the-sustainability-of-health-system-improvements-interventions-and-change-strategies-a-study-protocol-for-a-systematic-review
#17
Jeffrey Braithwaite, Luke Testa, Gina Lamprell, Jessica Herkes, Kristiana Ludlow, Elise McPherson, Margie Campbell, Joanna Holt
INTRODUCTION: The sustainability of healthcare interventions and change programmes is of increasing importance to researchers and healthcare stakeholders interested in creating sustainable health systems to cope with mounting stressors. The aim of this protocol is to extend earlier work and describe a systematic review to identify, synthesise and draw meaning from studies published within the last 5 years that measure the sustainability of interventions, improvement efforts and change strategies in the health system...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29132834/folic-acid-intake-and-folate-status-and-colorectal-cancer-risk-a%C3%A2-systematic-review-and-meta-analysis
#18
Sara Moazzen, Roya Dolatkhah, Jafar Sadegh Tabrizi, Jabraeel Shaarbafi, Behrooz Z Alizadeh, Geertruida H de Bock, Saeed Dastgiri
BACKGROUND & AIMS: To evaluate the controversies among the studies assessing the association between folic acid intake or folate status and colorectal cancer risk. METHODS: PubMed, Cochrane library and references of related articles were searched from January 2000 to September 2016. Studies on folic acid intake or folate status and colorectal cancer or adenoma risk were included. Full text review was conducted for potentially eligible studies. Quality assessment was performed...
October 28, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29132417/quantifying-mitochondrial-dna-copy-number-using-robust-regression-to-interpret-real-time-pcr-results
#19
Paulo Refinetti, David Warren, Stephan Morgenthaler, Per O Ekstrøm
BACKGROUND: Real time PCR (rtPCR) is a quantitative assay to determine the relative DNA copy number in a sample versus a reference. The [Formula: see text] method is the standard for the analysis of the output data generated by an rtPCR experiment. We developed an alternative based on fitting a robust regression to the rtPCR signal. This new data analysis tool reduces potential biases and does not require all of the compared DNA fragments to have the same PCR efficiency. RESULTS: Comparing the two methods when analysing 96 identical PCR preparations showed similar distributions of the estimated copy numbers...
November 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29132364/-i-m-not-strong-enough-i-m-not-good-enough-i-can-t-do-this-i-m-failing-a-qualitative-study-of-low-socioeconomic-status-smokers-experiences-with-accesssing-cessation-support-and-the-role-for-alternative-technology-based-support
#20
Veronica C Boland, Richard P Mattick, Hayden McRobbie, Mohammad Siahpush, Ryan J Courtney
BACKGROUND: The social gradient in smoking rates persist with an overrepresentation of smoking and its associated harms concentrated within lower socioeconomic status (SES) populations. Low-SES smokers are motivated to quit but face multiple barriers when engaging a quit attempt. An understanding of the current treatment service model from the perspectives of treatment-seeking low-SES smokers is needed to inform the design of alternative smoking cessation support services tailored to the needs of low-SES populations...
November 13, 2017: International Journal for Equity in Health
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