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https://www.readbyqxmd.com/read/28101432/atypical-hemolytic-uremic-syndrome-in-first-trimester-pregnancy-successfully-treated-with-eculizumab
#1
Gabriela Andries, Michael Karass, Srikanth Yandrapalli, Katherine Linder, Delong Liu, John Nelson, Rahul Pawar, Savneek Chugh
BACKGROUND: Atypical hemolytic uremic syndrome is a rare disorder which is known to cause acute thrombotic microangiopathy during pregnancy with poor maternal and fetal outcomes. Atypical hemolytic uremic syndrome is caused mostly by dysregulation of alternative complement pathway secondary to genetic mutations. Most of the cases reported have been in the post-partum period. We report a rare case of a patient who presents with thrombotic microangiopathy in the first trimester of her eleventh pregnancy and was successfully treated with eculizumab...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/28078751/cardiac-remodelling-during-normotensive-and-hypertensive-complicated-pregnancies-a-systematic-review-and-meta-analysis
#2
REVIEW
Sander de Haas, Chahinda Ghossein-Doha, Lauren Geerts, Sander Mj van Kuijk, Joris van Drongelen, Marc Ea Spaanderman
OBJECTIVE: The aim of this systematic review and meta-analyses was to comprehensively describe the normotensive pattern of cardiac remodelling during human singleton pregnancies and compared to that during hypertensive complicated pregnancies. METHODS: We performed a meta-analysis of the current literature on cardiac remodelling during normotensive and complicated pregnancies. Literature was retrieved from PubMed (NCBI) and Embase (Ovid) databases. Included studies needed to report a reference measurement (matched non-pregnant control group, pre-pregnancy, or post-partum) and measurements during a predetermined gestational interval...
January 12, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28065966/implementation-of-warning-tool-to-improve-maternal-newborn-health-outcomes-in-a-developing-country
#3
Sana Sheikh, Rahat Qureshi, Sidrah Nausheen, Rozina Sikandar
OBJECTIVE: To improve health outcomes through the implementation of national early warning sign tool for babies delivered through emergency caesarean section in off-work hours. METHODS: This comparative clinical study was conducted at the Aga Khan Hospital for Women and Children, Karachi, from April to August 2014, and comprised women who had an emergency caesarean section. Maternal and perinatal outcomes were compared of patients in Group A and Group B which represented individuals before and after the implementation of the national early warning score respectively...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28065954/postpartum-depression-and-associated-factors-after-emergency-peripartum-hysterectomy
#4
Mehmet Baki Senturk, Yusuf Cakmak, Ahmet Ozalp
OBJECTIVE: To investigate post-partum depression after emergency peripartum hysterectomy and associated factors. METHODS: This cross-sectional controlled study was conducted at Batman Gynaecology and Paediatric Diseases Hospital, Batman, Turkey, between June 15 and July 23, 2015, and comprised cases of patients with peripartum hysterectomy and of those who had experienced surgical procedures other than hysterectomy (hypogastric artery ligation and/or B-Lynch suture)...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28050450/iv-ferric-carboxymaltose-vs-oral-iron-in-the-treatment-of-post-partum-iron-deficiency-anaemia
#5
Sree Chandana Damineni, Suchitra Thunga
INTRODUCTION: Iron deficiency is the most common cause of Post-partum anaemia, reported as 50-60% in India. It is primarily due to inadequate iron intake and due to peripartum blood loss. It has been associated with significant post-partum complications. Therefore, Post-partum iron deficiency warrants greater attention and higher quality care. Oral iron treatment has been considered the standard of care. However, parenteral iron treatment is expected to be advantageous in cases where oral iron therapy is not possible...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28050068/blood-transfusion-practices-among-delivery-cases-a-retrospective-study-of-two-years
#6
S K Kathpalia, Jaya Chawla, A K Harith, Priyanka Gupta, Anupam Anveshi
BACKGROUND: Many women die while going through childbirth; hemorrhage being common cause for maternal mortality. Many maternal deaths can be saved by building up hemoglobin antenatally and timely blood transfusion. The transfusion may result in many complications hence the blood transfusion practices should be streamlined and adhered to and reviewed periodically. This retrospective study was undertaken at one of the tertiary care hospital to find out the blood demand and utilization practices among the delivery cases and suggest measures if any to improve the existing practices...
December 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28012808/post-partum-hemorrhage-complicated-by-reverse-takotsubo-cardiogenic-shock-a-novel-therapeutic-approach
#7
John Papanikolaou, Demosthenes Makris, Vasiliki Tsolaki, Konstantinos Spathoulas, Epaminondas Zakynthinos
Takotsubo Cardiomyopathy (TTC) is a type of transient, yet severe left ventricular systolic dysfunction, rarely complicating extreme emotional stress ("primary" TTC) or critical medical/surgical illness ("secondary" TTC forms). Although usually reversible, TTC may result in cardiogenic shock with dismal prognosis. "Secondary" TTC forms are particularly in danger for this complication, bearing significantly worse short and long-term prognosis. Herein, we report a rare case of a life-threatening "secondary" TTC in a patient with post-cesarean section severe hemorrhage, and we point out that early co-administration of esmolol and levosimendan might be an effective and safe therapeutic approach in "reversing" TTC-induced cardiogenic shock, especially when invasive therapeutic strategies are practically unfeasible...
December 19, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28004456/maternal-endothelial-function-and-vascular-stiffness-after-hellp-syndrome-a-case-control-study
#8
Rossana Orabona, Edoardo Sciatti, Enrico Vizzardi, Ivano Bonadei, Federico Prefumo, Adriana Valcamonico, Marco Metra, Tiziana Frusca
OBJECTIVES: To assess endothelial function and arterial stiffness in women with a previous pregnancy complicated by haemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, and compare them with women with a previous preeclampsia (PE) without HELLP and controls with uncomplicated pregnancies. METHODS: Women who have had a singleton pregnancy complicated by PE with (n = 49) or without (n = 60) HELLP syndrome and controls (n = 60) underwent peripheral arterial tonometry (EndoPAT method) and pulse wave velocity (PWV) assessment at 6 months-4 years after delivery...
December 22, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27987342/comparison-between-two-management-protocols-for-postpartum-hemorrhage-during-cesarean-section-in-placenta-previa-balloon-protocol-versus-non-balloon-protocol
#9
Mohammad Ahmed Maher, Ahmed Abdelaziz
AIM: This study was conducted to compare two management protocols for post-partum hemorrhage (PPH) during cesarean section (CS) in placenta previa (PP), Bakri balloon protocol versus non-balloon protocol. Secondary analysis among balloon treated cases was also performed to identify predictors of success, failure or complications, if any. METHODS: A prospective cohort study was conducted in two hospitals in Saudi Arabia, including cases that developed PPH during CS for PP...
December 17, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27987297/misdiagnosis-of-obstetrical-cases-and-the-clinical-and-cost-consequences-to-patients-a-cross-sectional-study-of-urban-providers-in-the-philippines
#10
Riti Shimkhada, Orville Solon, Diana Tamondong-Lachica, John W Peabody
BACKGROUND: Misdiagnosis may be a significant and under-recognized quality of care problem. In birthing facilities located in anurban Philippine setting, we investigated the diagnostic accuracy for three obstetric conditions: cephalopelvic disproportion (CPD), post-partum hemorrhage (PPH), and pre-eclampsia. DESIGN: Identical simulated cases were used to measure diagnostic accuracy for every provider (n=103). We linked misdiagnosis - identified by the simulated cases - to obstetrical complications of the patients at the participating facilities...
2016: Global Health Action
https://www.readbyqxmd.com/read/27966404/-ischemic-stroke-in-young-women
#11
M S Ekker, M J H Wermer, N P Riksen, C J M Klijn, F E de Leeuw
- In virtually all age groups, the incidence of ischemic stroke is higher in men. However, in women aged between 25-49 years the prevalence is higher than in men. Female-specific risk factors and disorders may explain this peak.- Pregnancy and the post-partum period are associated with physiological changes which can increase blood coagulation. Complications during pregnancy may also increase the risk of ischaemic stroke.- Migraine with aura and antiphospholipid syndrome are disorders which are also associated with an increased risk of ischaemic stroke...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27918156/-cesarean-section-incidence-and-vaginal-birth-success-rate-at-term-pregnancy-after-myomectomy
#12
L Mekiňová, P Janků, E Filipinská, J Kadlecová, P Ventruba
OBJECTIVE: To compare the incidence of primary and acute cesarean section (CS) and to compare success rate of vaginal delivery. To determine the frequency of maternal complications and evaluation of post-partum condition of the newborn. STUDY DESIGN: Prospective, pilot, cohort study. SETTING: Department of Gynecology and Obstetrics Masaryk University and University Hospital Brno. METHODS: Analysis of patients with physiologically ongoing singleton pregnancy and term delivery, vertex presentation...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27897027/-acute-uterine-inversion-after-delivery
#13
E Pechová, I Bydžovská, M Krausová, M Lubušký
OBJECTIVE: A case of acute inversion of the uterus after childbirth, in which we successfully perform a manual vaginal reposition of the uterus. DESIGN: Case report. SETTING: Department of Obstetrics and Gynaecology, Krajská nemocnice Liberec, a.s.; Department of Obstetrics and Gynaecology, Palacky University Hospital, Olomouc. OBSERVATION: Our case report describes acute post-partum uterine inversion of the second degree, which developed after delivery in a 36-year-old primigravida...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27881104/provider-adherence-to-first-antenatal-care-guidelines-and-risk-of-pregnancy-complications-in-public-sector-facilities-a-ghanaian-cohort-study
#14
Mary Amoakoh-Coleman, Kerstin Klipstein-Grobusch, Irene Akua Agyepong, Gbenga A Kayode, Diederick E Grobbee, Evelyn K Ansah
BACKGROUND: Guideline utilization aims at improvement in quality of care and better health outcomes. The objective of the current study was to determine the effect of provider complete adherence to the first antenatal care guidelines on the risk of maternal and neonatal complications in a low resource setting. METHODS: Women delivering in 11 health facilities in the Greater Accra region of Ghana were recruited into a cohort study. Their first antenatal visit records were reviewed to assess providers' adherence to the guidelines, using a thirteen-point checklist...
November 24, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27854380/physiologic-adaptation-of-plasma-volume-during-pregnancy-a-systematic-review-and-meta-analysis
#15
REVIEW
Sander de Haas, Chahinda Ghossein-Doha, Sander Mj van Kuijk, Joris van Drongelen, Marc Ea Spaanderman
OBJECTIVE: The aim of this systematic review and meta-analyses was to comprehensively describe the physiological pattern of gestational plasma volume adjustments during human singleton pregnancies and compare this to the pattern of pregnancies complicated by pregnancy-induced hypertension, preeclampsia or fetal growth restriction. METHODS: We performed a meta-analysis of the current literature on plasma volume adjustments during physiological and complicated pregnancies...
November 11, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27846760/outcome-of-breastfed-infants-following-post-partum-methylergonovine-treatment
#16
Oded Gilad, Paul Merlob, Bracha Stahl, Noa Averbuch, Gil Klinger
OBJECTIVE: To evaluate maternal and breastfed infant's outcome following post-partum maternal use of methylergonovine. METHODS: A prospective, controlled observational study design was used. Mothers who contacted Beilinson Teratology Information Service (BELTIS) were followed by phone interview. Data on lactation, neonatal symptoms and outcomes at the age of 1-3 years were obtained. Mothers' breastfeeding while treated with methylergonovine and their infants were compared to a matched control group of breastfeeding mothers using a drug known to be safe during lactation (amoxicillin)...
November 16, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27795789/polymyositis-anti-srp-antibodies-and-pregnancy-about-2-cases
#17
Cissé Ousmane, Ba El Hadji Makhtar, Ba Fatoumata, Gams Daniel Massi, Daddah Sami Mouhamed Lémine, Diop-Sène Marieme Soda, Sow Adjaratou Dieynaba, Basse Anna, Seck Lala Bouna, Ndiaye Moustapha, Diop Amadou Gallo, Ndiaye Mouhamadou Mansour
Anti-SRP myopathy represents 4 to 6% of all the inflammatory myopathies. It has been described since the 80s and its influence on pregnancy and vice versa has been highlighted recently. We report two cases of anti-SRP myopathy associated with pregnancy. In the first case, the initial manifestations of the disease started in post partum and the second case was an anti-SRP myopathy patient before pregnancy. In both cases we objectified outbreaks during post-partum. Pregnancy seems to promote outbreaks. The inactive myopathy seems to presents no serious maternal-fetal complications as well as the usual dose of corticosteroids...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27783611/lactate-in-amniotic-fluid-predictor-of-labor-outcome-in-oxytocin-augmented-primiparas-deliveries
#18
Eva Wiberg-Itzel, Andrea B Pembe, Hans Järnbert-Pettersson, Margareta Norman, Anna-Carin Wihlbäck, Irene Hoesli, Monya Todesco Bernasconi, Elie Azria, Helena Åkerud, Elisabet Darj
BACKGROUND: One of the major complications related to delivery is labor dystocia, or an arrested labor progress. Many dystocic deliveries end vaginally after administration of oxytocin, but a large numbers of women with labor dystocia will undergo a long and unsafe parturition. As a result of the exertion required in labor, the uterus produces lactate. The uterine production of lactate is mirrored by the level of lactate in amniotic fluid (AFL). OBJECTIVES: To evaluate whether the level of AFL, analysed in a sample of amniotic fluid collected vaginally at arrested labor when oxytocin was needed, could predict labor outcome in nulliparous deliveries...
2016: PloS One
https://www.readbyqxmd.com/read/27765939/inadvertent-methylergonovine-administration-to-a-neonate
#19
Bryan M Corbett, Charles O'Connell, Mallory A Boutin, Nabil I Fatayerji, Charles W Sauer
BACKGROUND Methylergonovine is an ergot alkaloid used to treat post-partum hemorrhage secondary to uterine atony. Mistaking methylergonovine for vitamin K with accidental administration to the neonate is a rare iatrogenic illness occurring almost exclusively in the delivery room setting. Complications of ergot alkaloids in neonates include respiratory depression, seizures, and death. CASE REPORT A term infant was inadvertently given 0.1 mg of methylergonovine intramuscularly in the right thigh. The error was only noted when the vial of medication was scanned, after administration, identifying it as methylergonovine rather than vitamin K...
October 21, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27743977/clinical-management-of-pregnancy-in-the-obese-mother-before-conception-during-pregnancy-and-post-partum
#20
REVIEW
Ronald Ching Wan Ma, Maria Ines Schmidt, Wing Hung Tam, Harold David McIntyre, Patrick M Catalano
The global epidemic of obesity has led to an increasing number of obese women of reproductive age. Obesity is associated with reduced fertility, and pregnancies complicated by maternal obesity are associated with adverse outcomes, including increased risk of gestational diabetes, pre-eclampsia, preterm birth, instrumental and caesarean births, infections, and post-partum haemorrhage. The medical and obstetric management of obese women is focused on identifying, addressing, and preventing some of these associated complications, and is a daunting challenge given the high percentage of patients with obesity and few therapeutic options proven to improve outcomes in this population...
December 2016: Lancet Diabetes & Endocrinology
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