keyword
https://read.qxmd.com/read/25577363/high-throughput-method-for-the-determination-of-nitroimidazoles-in-muscle-samples-by-liquid-chromatography-coupled-to-mass-spectrometry
#21
JOURNAL ARTICLE
A Rúbies, G Sans, P Kumar, M Granados, R Companyó, F Centrich
We present a high-throughput confirmatory method for the analysis of 11 nitroimidazoles in muscle samples (metronidazole, MNZ; dimetridazole, DMZ; ronidazole, RNZ; tinidazole, TNZ; carnidazole, CRZ; secnidazole semihydrate, SCZ; ornidazole, ORZ; metronidazole-hydroxy, MNZ-OH; ipronidazole, IPZ; ipronidazole-hydroxy, IPZ-OH; and dimetridazole-hydroxy, HMMNI). Extraction with acetonitrile is efficient and simple, with the majority of recoveries ranging between 65 and 101%, and without the need for clean-up of the extracts...
June 2015: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/25049211/enantioselective-hplc-determination-and-pharmacokinetic-study-of-secnidazole-enantiomers-in-rats
#22
JOURNAL ARTICLE
Jiangbo Du, Yifan Zhang, Yao Chen, Dongqin Liu, Xiaoyan Chen, Dafang Zhong
Secnidazole is a long-lasting nitroimidazole antimicrobial agent that is used as racemic mixture in clinical settings. We developed and validated an enantioselective high-performance liquid chromatography method to determine secnidazole enantiomers in rat plasma. Secnidazole enantiomers and S-(-)-ornidazole (internal standard) were extracted from 50 μL of rat plasma using diethyl ether-dichloromethane (3:2, v/v). Baseline resolution (Rs=2.45) was achieved within 7.0 min on a Chiral-AGP column (150 mm × 4...
August 15, 2014: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/24359723/determination-of-three-nitroimidazoles-in-rabbit-plasma-by-two-step-stacking-in-capillary-zone-electrophoresis-featuring-sweeping-and-micelle-to-solvent-stacking
#23
JOURNAL ARTICLE
Xiupei Yang, Xiumei Cheng, Yingyun Lin, Zhijing Tan, Linxiang Xie, Martin M F Choi
This study reports a sweeping and micelle to solvent stacking (MSS) method for fast stacking of nitroimidazoles in capillary zone electrophoresis (CZE). The optimal experimental conditions are run buffer of 25mM sodium phosphate (pH 1.5) and 0.50% (v/v) methanol, micellar solution of 30mM sodium dodecyl sulfate, applied voltage of 28kV, and sample and micellar solution injection of 100s. By applying this new on-line preconcentration technique, the nitroimidazoles content can be determined within 9min with the limit of detection (S/N=3) ranging 2...
January 17, 2014: Journal of Chromatography. A
https://read.qxmd.com/read/23394797/prevalence-hematology-and-treatment-of-balantidiasis-among-donkeys-in-and-around-lahore-pakistan
#24
RANDOMIZED CONTROLLED TRIAL
A Khan, M S Khan, M Avais, M Ijaz, M M Ali, T Abbas
The prevalence of Balantidium coli among donkeys in Lahore and adjoining areas was surveyed and a trial conducted to determine the efficacy of two antiprotozoal drugs: secnidazole (Dysen Forte) and Kalonji (Nigella sativa). Four-hundred donkeys were examined, and 73 (18.3%) were found positive for Balantidium coli. A slight decrease in PCV and an increase in Hb values of infected donkeys were found after antiprotozoal treatment. Secnidazole was 89.5% effective for the treatment of equine balantidiasis compared to 40...
September 1, 2013: Veterinary Parasitology
https://read.qxmd.com/read/22265553/determination-of-five-nitroimidazole-residues-in-artificial-porcine-muscle-tissue-samples-by-capillary-electrophoresis
#25
JOURNAL ARTICLE
Yingyun Lin, Yan Su, Xiulin Liao, Na Yang, Xiupei Yang, Martin M F Choi
A capillary electrophoresis (CE) method with ultraviolet detection has been developed for simultaneous detection and quantification of five nitroimidazoles including benzoylmetronidazole, dimetridazole, metronidazole, ronidazole, and secnidazole in porcine muscles. Nitroimidazoles in samples were extracted by ethyl acetate with subsequent clean-up by a strong cation exchange solid phase extraction column. The clean extracts were subjected to CE separation with optimal experimental conditions: pH 3.0 running buffer containing 25mM sodium phosphate and 0...
January 15, 2012: Talanta
https://read.qxmd.com/read/22186332/extractional-spectrophotometric-analysis-of-metronidazole-tinidazole-ornidazole-and-secnidazole-bases-through-acid-dye-complexation-using-bromothymol-blue-dye
#26
JOURNAL ARTICLE
Khaled M Darwish, Ismail Salama, Samia Mostafa, Mohamed El-Sadek
An easy, precise and valid extractional-spectrophotometric technique is described for the assessment of metronidazole (MNZ), tinidazole (TNZ), ornidazole (ONZ) and secnidazole (SNZ) in pure state and in their pharmaceutical formulations. The technique includes first the reduction of above cited drugs using HCl and zinc powder, then the formation of intense yellow colored ion-association complex species (1:3 drug/dye) using bromothymol blue (BTB) in a buffered aqueous acidic medium at pH 3-3.50. The colored products are extracted into dichloromethane and quantitatively determined at 416-420 nm...
January 2012: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/22024820/in-vitro-susceptibility-testing-of-dientamoeba-fragilis
#27
JOURNAL ARTICLE
N Nagata, D Marriott, J Harkness, J T Ellis, D Stark
Dientamoeba fragilis is a commonly encountered trichomonad which has been implicated as a cause of gastrointestinal disease in humans. Despite the frequency of reports recording infections with this parasite, little research has been undertaken in terms of antimicrobial susceptibility. The aim of this study was to evaluate the susceptibility of D. fragilis to several commonly used antiparasitic agents: diloxanide furoate, furazolidone, iodoquinol, metronidazole, nitazoxanide, ornidazole, paromomycin, secnidazole, ronidazole, tetracycline, and tinidazole...
January 2012: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/21809648/-development-and-use-of-test-systems-for-the-evaluation-of-sensitivity-of-trichomonas-vaginalisto-preparations-of-the-5-nitroimidazole-and-5-nitrofuran-groups
#28
JOURNAL ARTICLE
N S Makhlaĭ, L A Berezina, V N Verbov, A V Zakrevskaia, A B Zhebrun
AIM: Development of test system for the evaluation of sensitivity of Trichomonas vaginalis to preparations of the 5-nitroimidazole and 5-nitrofuran groups. MATERIALS AND METHODS: Determination of minimal cidic concentration (MCC) of antiprotozoal preparations was carried out by cultivating laboratory T. vaginalis strains in wells of plates with nutrient medium containing varying concentrations of these preparations. Evaluation of vitality of the agent was determined by using trypan blue vital stain and bysubsequent growth ability in nutrient medium without antiprotozoal preparations...
May 2011: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
https://read.qxmd.com/read/21741250/synthesis-molecular-modeling-and-biological-evaluation-of-%C3%AE-ketoacyl-acyl-carrier-protein-synthase-iii-fabh-as-novel-antibacterial-agents
#29
JOURNAL ARTICLE
Hong-Jia Zhang, Di-Di Zhu, Zi-Lin Li, Juan Sun, Hai-Liang Zhu
A series of novel cinnamic acid secnidazole ester derivatives have been designed and synthesized, and their biological activities were also evaluated as potential inhibitors of FabH. These compounds were assayed for antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. Compounds with potent antibacterial activities were tested for their E. coli FabH inhibitory activity. Compound 3n showed the most potent antibacterial activity with MIC of 1.56-6...
August 1, 2011: Bioorganic & Medicinal Chemistry
https://read.qxmd.com/read/20170531/could-giardiasis-be-a-risk-factor-for-low-zinc-status-in-schoolchildren-from-northwestern-mexico-a-cross-sectional-study-with-longitudinal-follow-up
#30
JOURNAL ARTICLE
Luis Quihui, Gloria G Morales, Rosa O Méndez, Johanna G Leyva, Julián Esparza, Mauro E Valencia
BACKGROUND: Both giardiasis and zinc deficiency are serious health problems worldwide. In Mexico, the prevalence of G. intestinalis was estimated at 32% in 1994. It remains a health problem in northwestern Mexico. Recent surveys (1987, 1995, and 1999) reported zinc deficiency in the Mexican population. The association of giardiasis and malabsorption of micronutrients has been well documented, although the association with zinc remains controversial. This study investigated the association between giardiasis and zinc deficiency in schoolchildren from northwestern Mexico...
February 20, 2010: BMC Public Health
https://read.qxmd.com/read/19856497/-in-vitro-effect-of-secnidazole-benzoate-on-trichomonas-vaginalis
#31
JOURNAL ARTICLE
Xiao-Xiang Zhang, Shan-Shan Zheng, Mei-Mei Zhu
OBJECTIVE: To research the trichomonacidal effect of secnidazole benzoate in vitro. METHODS: Trichomonas vaginalis was cultured in liver extract medium in 96-well microplate. The culture suspension of Trichomonas vaginalis was divided into four groups: secnidazole benzoate, secnidazole, metronidazole and control, with medium as blank control. MTT colorimetric assay was applied to determine the inhibitory effect of secnidazole benzoate on the proliferation of Trichomonas vaginalis...
April 2009: chinese Journal of Parasitology & Parasitic Diseases
https://read.qxmd.com/read/19485222/validated-method-for-determination-of-eight-banned-nitroimidazole-residues-in-natural-casings-by-lc-ms-ms-with-solid-phase-extraction
#32
JOURNAL ARTICLE
Hanwen Sun, Fengchi Wang, Lianfeng Ai, Chunhai Guo, Ruichun Chen
A sensitive method based on solid-phase extraction-liquid chromatography-tandem mass spectrometry interfaced with electrospray ionization (SPE-LC-MS/MS-ESI) was developed for the simultaneous determination of 8 banned nitroimidazole (NOZ) drugs including metronidazole (MNZ), ronidazole (RNZ), dimetridazole (DMZ), tinidazole, ornidazole, secnidazole, metronidazole-OH (MNZOH, the metabolite of MNZ), and 2-hydroxymethyl-1-methyl-5-nitroimidazole (HMMNI, the metabolite of RNZ and DMZ) in natural casings. After extraction with ethyl acetate and evaporation, the NOZs were reconstituted in ethyl acetate and purified on a strong cation-exchange SPE column, and then LC/MS/MS analysis was performed by positive ESI applying multiple reaction monitoring of 2 transition reactions for each compound...
March 2009: Journal of AOAC International
https://read.qxmd.com/read/19072620/molecular-structure-and-vibrational-spectroscopic-investigation-of-secnidazole-using-density-functional-theory
#33
JOURNAL ARTICLE
Soni Mishra, Deepika Chaturvedi, Poonam Tandon, V P Gupta, A P Ayala, S B Honorato, H W Siesler
Secnidazole (alpha,2-dimethyl-5-nitro-1H-imidazole-1-ethanol) is an antimicrobical drug, and it is particularly effective in the treatment of amebiasis, giardiasis, trichomoniasis, and bacterial vaginosis. Secnidazole crystallizes as a hemihydrate, which belongs to a monoclinic system having space group P2(1)/c, with a = 12.424 A, b = 12.187 A, c = 6.662 A, and beta = 100.9 degrees. The optimized geometries and total energies of different conformers of the secnidazole molecule have been determined by the method of density functional theory (DFT)...
January 8, 2009: Journal of Physical Chemistry. A
https://read.qxmd.com/read/17719280/simultaneous-determination-of-seven-nitroimidazole-residues-in-meat-by-using-hplc-uv-detection-with-solid-phase-extraction
#34
JOURNAL ARTICLE
Han-Wen Sun, Feng-Chi Wang, Lian-Feng Ai
A method was developed for the determination of the seven nitroimidazoles including metronidazole (MNZ), ronidazole (RNZ), dimetridazole (DMZ), tinidazole (TNZ), ornidazole (ONZ), secnidazole (SNZ) and the common metabolite of RNZ and hydroxydimetridazole (DMOHZ) in poultry and pork muscles by high-performance liquid chromatography (HPLC) with ultraviolet detection (UV). After extraction with ethyl acetate and evaporation, the nitroimidazoles were redissolved in ethyl acetate and purified using strong cation exchange (SCX) solid-phase extraction (SPE) column...
October 1, 2007: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/17221933/determination-of-secnidazole-in-human-plasma-by-high-performance-liquid-chromatography-with-uv-detection-and-its-application-to-the-bioequivalence-studies
#35
JOURNAL ARTICLE
Xiaoyu Li, Jianguo Sun, Guangji Wang, Yuanting Zheng, Bei Yan, Haitang Xie, Yi Gu, Hongchan Ren
A simple, accurate, precise and sensitive HPLC-UV method was developed for the determination of secnidazole in human plasma. Secnidazole and tinidazole (IS) were extracted from 0.2 mL of human plasma by ethyl acetate. Secnidazole was then separated by HPLC on a Diamond C(18) column and quantified by ultraviolet detection at 319 nm. The mobile phase consisted of acetonitrile-aqueous 5 mm sodium acetate (30:70, v/v) containing of 0.1% acetic acid adjusted to pH 4.0, and the flow rate was 1.0 mL/min. The low limit of quantification was 0...
March 2007: Biomedical Chromatography: BMC
https://read.qxmd.com/read/15733882/low-dose-secnidazole-in-the-treatment-of-bacterial-vaginosis
#36
RANDOMIZED CONTROLLED TRIAL
J T Núñez, G Gómez
OBJECTIVE: To determine whether bacterial vaginosis could be cured with a single 1-g oral dose of secnidazole. MATERIAL AND METHODS: A total of 80 women were recruited at the outpatient gynecologic clinic of Manuel Noriega Hospital, Maracaibo, Venezuela. Diagnosis and patient enrollment were based on the Amsel criteria. The participants were randomized to 2 groups. In group 1 (n=44) participants received a single 1-g oral dose and in group 2 (n=32) participants received a single 2-g oral dose of secnidazole...
March 2005: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/15474063/spectrophotometric-determination-of-metronidazole-and-secnidazole-in-pharmaceutical-preparations
#37
JOURNAL ARTICLE
T Saffaj, M Charrouf, A Abourriche, Y Abboud, A Bennamara, M Berrada
A rapid and sensitive spectrophotometric method is proposed for determination of metronidazole and secnidazole. The method depends on the reduction of metronidazole and secnidazole molecule with zinc dust and hydrochloric acid flowed by diazotization and coupling with 8-quinolinol to give red colored chromogens easily measured spectrophotometrically which has lambda(max) = 500 nm. The experimental conditions were optimized and Berr's law was obeyed over the applicable concentration ranges both techniques were applied successfully to a wide variety of pharmaceutical preparations...
October 2004: Il Farmaco
https://read.qxmd.com/read/14701947/ciprofloxacin-tinidazole-combination-fluconazole-azithromicin-secnidazole-kit-and-doxycycline-metronidazole-combination-therapy-in-syndromic-management-of-pelvic-inflammatory-disease-a-prospective-randomized-controlled-trial
#38
RANDOMIZED CONTROLLED TRIAL
M Malhotra, J B Sharma, S Batra, R Arora, S Sharma
BACKGROUND: Pelvic inflammatory disease is a common problem faced by the gynecologists in there out patient department. AIM: The aim of the study was to evaluate the efficacy of three treatment combinations in the syndromic management of pelvic inflammatory disease in the out patient setting. SETTING DESIGN: In the medical college hospital patients presenting in gynecology out patient department were enrolled. MATERIAL AND METHODS: One hundred and sixty five women with diagnosis of pelvic inflammatory disease were randomized into three equal groups getting ciprofloxacin (500 mg) and tinidazole (600 mg) combination twice daily for 7 days (Group 1), a kit containing fluconazole (150 mg), azithromycin (1 gm) and secnidazole (2 mg) as one time dose (Group 2) and Doxycycline 100mg twice daily and metronidazole 200 mg thrice daily for seven days (Group 3)...
December 2003: Indian Journal of Medical Sciences
https://read.qxmd.com/read/12170343/low-efficacy-of-an-ultra-short-term-once-daily-dose-triple-therapy-with-omeprazole-azithromycin-and-secnidazole-for-helicobacter-pylori-eradication-in-peptic-ulcer
#39
JOURNAL ARTICLE
Fernando Marcuz Silva, Jaime Natan Eisig, Ethel Zimberg Chehter, Júlio Jovino da Silva, Antonio Atílio Laudanna
PURPOSE: To determine the eradication rate of an ultra-short treatment schedule for Helicobacter pylori infection in a population with peptic ulcers, using omeprazole, secnidazole, and azithromycin in a once-daily dose for 3 days. METHODS: Thirty patients with peptic ulcer diagnosed by upper endoscopy and for Helicobacter pylori infection by rapid urease test and histologic examination received omeprazole 40 mg, secnidazole 1000 mg, and azithromycin 500 mg, administered once daily for 3 days...
January 2002: Revista do Hospital Das Clínicas
https://read.qxmd.com/read/11204945/physico-chemical-and-solid-state-characterization-of-secnidazole
#40
JOURNAL ARTICLE
A B Rivera, R G Hernández, H Novoa de Armas, D M Elizástegi, M V Losada
Secnidazole (hydroxy-2-propyl)-l-methyl-2-nitro-5-imidazole) is an antimicrobic agent. This drug has pharmacological activity against intestinal and hepatic amebiasis, giardiasis and vaginal trichomoniasis. This paper shows the physicochemical parameters of secnidazole determined during a preformulation study. The determination of the apparent partition coefficient and the profile of solubility in dependence of pH demonstrate the basic characteristic of the drug. The dissolution assay was performed to evaluate its behavior in water...
November 2000: Il Farmaco
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