Mengjie Guo, Risa Higashita, Chen Lin, Lingxi Hu, Wan Chen, Fei Li, Gilda Wing Ki Lai, Anwell Nguyen, Rei Sakata, Keiichiro Okamoto, Bo Tang, Yanwu Xu, Huazhu Fu, Fei Gao, Makoto Aihara, Xiulan Zhang, Jin Yuan, Shan Lin, Christopher Kai-Shun Leung, Jiang Liu
BACKGROUND: The crystalline lens is a transparent structure of the eye to focus light on the retina. It becomes muddy, hard and dense with increasing age, which makes the crystalline lens gradually lose its function. We aim to develop a nuclear age predictor to reflect the degeneration of the crystalline lens nucleus. METHODS: First we trained and internally validated the nuclear age predictor with a deep-learning algorithm, using 12 904 anterior segment optical coherence tomography (AS-OCT) images from four diverse Asian and American cohorts: Zhongshan Ophthalmic Center with Machine0 (ZOM0), Tomey Corporation (TOMEY), University of California San Francisco and the Chinese University of Hong Kong...
July 26, 2023: British Journal of Ophthalmology