Yi-Hui Ou, Juliana Tereza Colpani, Crystal S Cheong, Weiqiang Loke, As Tar Thant, E Ching Shih, Frank Lee, Siew-Pang Chan, Ching-Hui Sia, Chieh-Yang Koo, Serene Wong, Aiping Chua, Chin-Meng Khoo, William Kong, Calvin W Chin, Pipin Kojodjojo, Philip E Wong, Mark Y Chan, A Mark Richards, Peter A Cistulli, Chi-Hang Lee
BACKGROUND: Hypertension guidelines recommend diagnosis and treatment of obstructive sleep apnea (OSA) in patients with hypertension. The mandibular advancement device (MAD) is an oral appliance therapy for patients who decline or cannot tolerate CPAP. OBJECTIVE: We compared the relative effectiveness of MAD versus CPAP in reducing 24-hour ambulatory BP. METHODS: In an investigator-initiated, randomized, non-inferiority trial (pre-specified margin 1...
March 13, 2024: Journal of the American College of Cardiology