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https://www.readbyqxmd.com/read/29151300/the-effect-of-antidiuretic-hormone-on-urine-and-serum-electrolyte-levelsin-children-with-primary-monosymptomatic-nocturnal-enuresis
#1
(no author information available yet)
Background/aim: The data concerning the effects of desmopressin on water/electrolyte disturbances of children with primary monosymptomatic nocturnal enuresis (PMNE) are limited. In the present study we aimed to evaluate the effect and tolerability of desmopressin on blood and urine electrolytes and osmolality in PMNE.Materials and methods: Thirty-five children with PMNE between the ages of 5 and 15 participated in the study. Patients collected urine during the daytime and acknowledged the night time fluid restriction before starting to use the desmopressin tablets...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29137079/treatment-of-hypermyoglobinemia-after-crs-hipec-for-patients-with-peritoneal-carcinomatosis-a-retrospective-comparative-study
#2
Gang Liu, Zhong-He Ji, Yang Yu, Xin-Bao Li, Yan-Bin Zhang, Kai-Wen Peng, Yan Li
This retrospective comparative study aims to explore the time courses of serum myoglobin (Mb) changes, and summarize our experience in treating patients with hypermyoglobinemia after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).This study covered 60 patients with peritoneal carcinomatosis treated with CRS + HIPEC as the study group, and another 25 cancer patients treated with conventional extensive surgery without HIPEC as the control group from February to October 2016...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29119585/effects-of-dopamine-receptor-antagonist-antipsychotic-therapy-on-blood-pressure
#3
REVIEW
N H Gonsai, V H Amin, C G Mendpara, R Speth, G M Hale
WHAT IS KNOWN AND OBJECTIVE: Hypertension, a major risk factor for adverse cardiovascular events, such as stroke and myocardial infarction, affects 80 million American adults. The aetiology of hypertension is multifaceted and difficult to identify. Dopamine receptors, especially those in the kidneys, play a role in blood pressure regulation, and alterations in their function can cause hypertension. The objective of this review was to investigate the association between the use of dopamine antagonists with hypertension focusing especially on second-generation antipsychotics, like clozapine that is D4 receptor antagonist...
November 8, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29114733/sodium-oxybate-for-excessive-daytime-sleepiness-and-sleep-disturbance-in-parkinson-disease-a-randomized-clinical-trial
#4
Fabian Büchele, Marc Hackius, Sebastian R Schreglmann, Wolfgang Omlor, Esther Werth, Angelina Maric, Lukas L Imbach, Stefan Hägele-Link, Daniel Waldvogel, Christian R Baumann
Importance: Sleep-wake disorders are a common and debilitating nonmotor manifestation of Parkinson disease (PD), but treatment options are scarce. Objective: To determine whether nocturnal administration of sodium oxybate, a first-line treatment in narcolepsy, is effective and safe for excessive daytime sleepiness (EDS) and disturbed nighttime sleep in patients with PD. Design, Setting, and Participants: Randomized, double-blind, placebo-controlled, crossover phase 2a study carried out between January 9, 2015, and February 24, 2017...
November 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29098731/clues-for-early-detection-of-autoimmune-addison-s-disease-myths-and-realities
#5
Å B Saevik, A-K Åkerman, K Grønning, I Nermoen, S F Valland, T E Finnes, M Isaksson, P Dahlqvist, R Bergthorsdottir, O Ekwall, J Skov, B G Nedrebø, A-L Hulting, J Wahlberg, J Svartberg, C Höybye, I H Bleskestad, A P Jørgensen, O Kämpe, M Øksnes, S Bensing, E S Husebye
BACKGROUND: Early detection of autoimmune Addison's disease (AAD) is important as delay in diagnosis may result in a life-threatening adrenal crisis and death. The classical clinical picture of untreated AAD is well-described, but methodical investigations are scarce. OBJECTIVE: Perform a retrospective audit of patient records with the aim of identifying biochemical markers for early diagnosis of AAD. MATERIAL AND METHODS: A multicentre retrospective study including 272 patients diagnosed with AAD at hospitals in Norway and Sweden during 1978-2016...
November 3, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29097069/dose-related-ethanol-intake-cx43-and-nav1-5-remodeling-exploring-insights-of-altered-ventricular-conduction-and-qrs-fragmentation-in-excessive-alcohol-users
#6
Chung-Lieh Hung, Yu-Jun Lai, Po-Ching Chi, Liang-Chia Chen, Ya-Ming Tseng, Jen-Yuan Kuo, Cheng-I Lin, Yao-Chang Chen, Shing-Jong Lin, Hung-I Yeh
BACKGROUND: Chronic, excessive ethanol intake has been linked with various electrical instabilities, conduction disturbances, and even sudden cardiac death, but the underlying cause for the latter is insufficiently delineated. METHODS: We studied surface electrocardiography (ECG) in a community-dwelling cohort with moderate-to-heavy daily alcohol intake (grouped as >90g/day, ≤90g/day, and nonintake). RESULTS: Compared with nonintake, heavier alcohol users showed markedly widened QRS duration and higher prevalence of QRS fragmentation (64...
October 30, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29092635/hydrogen-sulfide-ameliorates-zinc-induced-cell-death-in-neuroblastoma-sh-sy5y-cells
#7
Megumi Shimoji, Hirokazu Hara, Tetsuro Kamiya, Kensuke Okuda, Tetsuo Adachi
Previous reports have demonstrated that excess zinc (Zn(2+)) released from nerve terminals following cerebral ischemia causes brain injury. Therefore, disturbance of Zn(2+) homeostasis in the brain is thought to be closely linked to neurotoxicity. Recently, hydrogen sulfide (H2S), a gaseous mediator, has been reported to ameliorate ischemic brain injury. However, its mechanism is not fully understood. In this study, we examined whether sodium hydrogen sulfide (NaHS), an H2S donor, protects against Zn(2+) cytotoxicity using human neuroblastoma SH-SY5Y cells...
November 1, 2017: Free Radical Research
https://www.readbyqxmd.com/read/29084084/hydrogen-sulfide-improves-endothelial-dysfunction-in-hypertension-by-activating-peroxisome-proliferator-activated-receptor-delta-endothelial-nitric-oxide-synthase-signaling
#8
Lin Xiao, Jing-Hui Dong, Xu Teng, Sheng Jin, Hong-Mei Xue, Shang-Yu Liu, Qi Guo, Wei Shen, Xiao-Chen Ni, Yu-Ming Wu
OBJECTIVE: We aimed to elucidate the ameliorative effect of hydrogen sulfide (H2S) on endothelium-dependent relaxation disturbances via peroxisome proliferator-activated receptor delta/endothelial nitric oxide synthase (PPARδ/eNOS) pathway activation in hypertensive patients and rats. METHODS: Renal arteries were collected from normotensive and hypertensive patients who underwent nephron-sparing surgery. Renal arteries from 37 patients were cultured with or without sodium H2S (NaHS) 50 μmol/l...
October 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29077258/whole-exome-sequencing-identifies-a-novel-mutation-of-gpd1l-r189x-associated-with-familial-conduction-disease-and-sudden-death
#9
Hao Huang, Ya-Qin Chen, Liang-Liang Fan, Shuai Guo, Jing-Jing Li, Jie-Yuan Jin, Rong Xiang
Cardiac conduction disease (CCD) is a serious disorder and the leading cause of mortality worldwide. It is characterized by arrhythmia, syncope or even sudden cardiac death caused by the dysfunction of cardiac voltage-gated channel. Previous study has demonstrated that mutations in genes encoding voltage-gated channel and related proteins were the crucial genetic lesion of CCD. In this study, we employed whole-exome sequencing to explore the potential causative genes in a Chinese family with ventricular tachycardia and syncope...
October 27, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29063329/analysis-of-the-efficiency-of-microencapsulated-sustained-release-form-of-naloxone-on-the-experimental-model-of-fentanyl-poisoning
#10
N G Vengerovich, M A Yudin, V N Bykov, A S Nikiforov, O I Aleshina, A A Kuz'min, T M Ustinova, S V Gadzikovskii
We compared samples of microencapsulated naloxone prepared by using spray drying technique. 2-Hydroxypropyl-β-cyclodextrin, sodium alginate, polycaprolactone, and carboxymethyl cellulose were used as the carriers. It was found that the combination of naloxone with sodium alginate was characterized by the highest naloxone content in the matrix and the lowest release rate (100% release time was 60 min). Using the model of respiratory disturbances caused by 10 ED50 fentanyl (anesthetic effect), we studied the effects of naloxone-sodium alginate complex on the dynamics of CO2 concentration in the expired air...
October 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29062176/supplementation-of-%C3%AE-tocopherol-attenuates-minerals-disturbance-oxidative-stress-and-apoptosis-occurring-in-favism
#11
Khaled M M Koriem, Mahmoud S Arbid, Nawal E Gomaa
The favism is a metabolic disease that characterized with an acute hemolytic anemia where α-tocopherol is a type of tocopherol accumulated inside the human body. The objective of such a study was established to evaluate the effect of α-tocopherol in favism disorders. A total of 75 human cases were divided into 5 groups as follow; group 1 normal cases without any treatment and group 2 normal cases orally administrated α-tocopherol (200 mg/kg) once a day over 30 days period. Group 3 favism patients without any treatment...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29048424/analysis-of-human-cerebrospinal-fluid-monoamines-and-their-cofactors-by-hplc
#12
Marta Batllori, Marta Molero-Luis, Aida Ormazabal, Mercedes Casado, Cristina Sierra, Angels García-Cazorla, Manju Kurian, Simon Pope, Simon J Heales, Rafael Artuch
The presence of monoamines and their cofactors (the pterins and vitamin B6 (pyridoxal phosphate (PLP))) in human cerebrospinal fluid (CSF) can be used as indicators of the biosynthesis and turnover of dopamine and serotonin in the brain. In addition, abnormalities in the CSF levels of these molecules are associated with various neurological diseases, including genetic diseases leading to dopamine and serotonin deficiency. Here, we provide a set of quantitative high-performance liquid-chromatography (HPLC) approaches to determine CSF levels of monoamines and their cofactors...
November 2017: Nature Protocols
https://www.readbyqxmd.com/read/29039977/chronic-disruptions-of-circadian-sleep-regulation-induce-specific-proinflammatory-responses-in-the-rat-colon
#13
Lenka Polidarová, Pavel Houdek, Alena Sumová
Exposure to environmental conditions that disturb the daily rhythms has been shown to enhance the proinflammatory responses of immunostimulant-challenged immune system. However, it is not known whether circadian disturbances may stimulate unchallenged immune responses and thus contribute per se to the development of inflammation-related diseases. Our aim was to ascertain an effect of various conditions threatening the behavioral activity/rest cycle regulation, namely aging with or without melatonin, 6 h advance/delay phase shifts in the light/dark cycle repeated with a 2-day frequency and constant light, on expression of immune markers in the rat colon...
October 17, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29039315/prevention-of-liver-cirrhosis-by-silymarin
#14
Syeda Nuzhat Fatima Zaidi, Tabassum Mahboob
This study was designed to evaluate the effects of sylimarin supplementation on different biochemical parameters in thioacetamide induced cirrhotic rats. For this purpose 24 male Albino wistar rats were divided into four groups (n=6). Group I, remained healthy control rats, Group II, received thioacetamide (at a dose of 200mg/kg b.w, i.p, for 12 weeks, twice a week) in first phase and saline in second phase, Group III, received thioacetamide (200mg/kg b.w, i.p for 12 weeks, twice a week) in first phase and silymarin (orally at a dosage of 200mg/kg b...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29031352/disturbances-in-acid-base-potassium-and-sodium-balance-in-patients-with-ckd-new-insights-and-novel-therapies
#15
EDITORIAL
Jeffrey A Kraut
No abstract text is available yet for this article.
September 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29025027/maternal-melatonin-or-agomelatine-therapy-prevents-programmed-hypertension-in-male-offspring-of-mother-exposed-to-continuous-light
#16
You-Lin Tain, Yu-Ju Lin, Julie Y H Chan, Chien-Te Lee, Chien-Ning Hsu
Hypertension can originate from early-life insults, whereas maternal melatonin therapy can be protective in a variety of models of programmed hypertension. We hypothesize that melatonin or melatonin receptor agonist agomelatine can prevent programmed hypertension in adult offspring induced by maternal exposure to continuous light. Female Sprague-Dawley pregnant rats randomly divided into four groups: controls, rats exposed to continuous light, exposed to continuous light plus treated with agomelatine (50 mg/day i...
October 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28992493/long-term-impact-of-wildfire-on-soils-exposed-to-different-fire-severities-a-case-study-in-cadiretes-massif-ne-iberian-peninsula
#17
Marcos Francos, Xavier Úbeda, Paulo Pereira, Meritxell Alcañiz
Wildfires affect ecosystems depending on the fire regime. Long-term studies are needed to understand the ecological role played by fire, especially as regards its impact on soils. The aim of this study is to monitor the long-term effects (18years) of a wildfire on soil properties in two areas affected by low and high fire severity regimes. The properties studied were total nitrogen (TN), total carbon (TC), C/N ratio, soil organic matter (SOM) and extractable calcium (Ca), magnesium (Mg), sodium (Na) and potassium (K)...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28970786/circadian-clock-protein-content-and-daily-rhythm-of-locomotor-activity-are-altered-after-chronic-exposure-to-lead-in-rat
#18
Mariam Sabbar, Ouria Dkhissi-Benyahya, Abdelhamid Benazzouz, Nouria Lakhdar-Ghazal
Lead exposure has been reported to produce many clinical features, including parkinsonism. However, its consequences on the circadian rhythms are still unknown. Here we aimed to examine the circadian rhythms of locomotor activity following lead intoxication and investigate the mechanisms by which lead may induce alterations of circadian rhythms in rats. Male Wistar rats were injected with lead or sodium acetate (10 mg/kg/day, i.p.) during 4 weeks. Both groups were tested in the "open field" to quantify the exploratory activity and in the rotarod to evaluate motor coordination...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28957470/treatment-of-severe-cholera-a-review-of-strategies-to-reduce-stool-output-and-volumes-of-rehydration-fluid
#19
Thomas Butler
Background: Severe cholera is a life-threatening illness of hypovolemic shock and metabolic acidosis due to rapid and profuse diarrheal fluid loss. Emergency life-saving therapy is i.v. saline, optionally supplemented with potassium and alkali to correct the fluid deficit, potassium losses and acidosis. After this initial rehydration, for the next 2 days ongoing stool losses are replaced with oral rehydration solution (ORS), which contains sodium chloride, potassium and alkali together with glucose or rice powder as a source of glucose to serve as a carrier for sodium...
May 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28946065/sensitivity-and-toxic-mode-of-action-of-dietary-organic-and-inorganic-selenium-in-atlantic-salmon-salmo-salar
#20
M H G Berntssen, T K Sundal, P A Olsvik, H Amlund, J D Rasinger, V Sele, K Hamre, M Hillestad, L Buttle, R Ørnsrud
Depending on its chemical form, selenium (Se) is a trace element with a narrow range between requirement and toxicity for most vertebrates. Traditional endpoints of Se toxicity include reduced growth, feed intake, and oxidative stress, while more recent finding describe disturbance in fatty acid synthesis as underlying toxic mechanism. To investigate overall metabolic mode of toxic action, with emphasis on lipid metabolism, a wide scope metabolomics pathway profiling was performed on Atlantic salmon (Salmo salar) (572±7g) that were fed organic and inorganic Se fortified diets...
September 18, 2017: Aquatic Toxicology
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