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https://www.readbyqxmd.com/read/28107909/trapping-magnetic-nanoparticles-for-in-line-capillary-electrophoresis-in-a-liquid-based-capillary-coolant-system
#1
Pranov Ramana, Erwin Adams, Patrick Augustijns, Ann Van Schepdael
A method to trap magnetic nanoparticles inside the electrophoretic capillary has been developed without disabling and disturbing the coolant liquid recirculation. The complete optimization from setting up of the external magnetic field to injecting the magnetic nanoparticles in order to facilitate efficient trapping is described. In addition to this, the setup has been tested with 150mM sodium phosphate buffer as the background electrolyte at different pH values (2, 4, 6 and 8). All these pH values have been investigated at 25°C and 37°C to mimic room temperature and physiological temperature, respectively...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28105926/the-gene-expression-profile-of-renal-medulla-in-isiah-rats-with-inherited-stress-induced-arterial-hypertension
#2
Marina A Ryazanova, Larisa A Fedoseeva, Nikita I Ershov, Vadim M Efimov, Arcady L Markel, Olga E Redina
BACKGROUND: The changes in the renal function leading to a reduction of medullary blood flow can have a great impact on sodium and water homeostasis and on the long-term control of arterial blood pressure. The RNA-Seq approach was used for transcriptome profiling of the renal medulla from hypertensive ISIAH and normotensive WAG rats to uncover the genetic basis of the changes underlying the renal medulla function in the ISIAH rats being a model of the stress-sensitive arterial hypertension and to reveal the genes which possibly may contribute to the alterations in medullary blood flow...
December 22, 2016: BMC Genetics
https://www.readbyqxmd.com/read/28073790/clemizole-and-modulators-of-serotonin-signalling-suppress-seizures-in-dravet-syndrome
#3
Aliesha Griffin, Kyla R Hamling, Kelly Knupp, SoonGweon Hong, Luke P Lee, Scott C Baraban
Dravet syndrome is a catastrophic childhood epilepsy with early-onset seizures, delayed language and motor development, sleep disturbances, anxiety-like behaviour, severe cognitive deficit and an increased risk of fatality. It is primarily caused by de novo mutations of the SCN1A gene encoding a neuronal voltage-activated sodium channel. Zebrafish with a mutation in the SCN1A homologue recapitulate spontaneous seizure activity and mimic the convulsive behavioural movements observed in Dravet syndrome. Here, we show that phenotypic screening of drug libraries in zebrafish scn1 mutants rapidly and successfully identifies new therapeutics...
January 10, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28065573/rapid-evolution-of-tolerance-to-road-salt-in-zooplankton
#4
Kayla D Coldsnow, Brian M Mattes, William D Hintz, Rick A Relyea
Organisms around the globe are experiencing novel environments created by human activities. One such disturbance of growing concern is the salinization of freshwater habitats from the application of road deicing salts, which creates salinity levels not experienced within the recent evolutionary history of most freshwater organisms. Moreover, salinization can induce trophic cascades and alter the structure of freshwater communities, but knowledge is still scarce about the ability of freshwater organisms to adapt to elevated salinity...
December 27, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/28064417/the-mmp-9-timp-1-system-is-involved-in-fluoride-induced-reproductive-dysfunctions-in-female-mice
#5
Hong-Wei Wang, Wen-Peng Zhao, Pan-Pan Tan, Jing Liu, Jing Zhao, Bian-Hua Zhou
A total of 84 healthy female mice were kept with various concentrations of sodium fluoride (F) (0, 50, 100, 150 mg F(-)/L in drinking water for 90 days) and were then mated with healthy male mice for 1 week to study the effect of excessive fluoride on female reproductive function, particularly in embryo implantation. The rate of pregnancy, litter size, and the birth weight of female mice were evaluated. Ultrastructural changes of uteri tissues were observed by transmission electron microscopy (TEM). The mRNA expression levels of MMP-9 and TIMP-1 were determined by quantitative real-time PCR...
January 7, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28060134/severe-hyponatremia-in-a-single-center-series-of-84-homogenously-treated-children-with-acute-lymphoblastic-leukemia
#6
Szymon Janczar, Beata Zalewska-Szewczyk, Wojciech Mlynarski
Electrolyte abnormalities are hallmark metabolic disturbances during the treatment of acute lymphoblastic leukemia (ALL). Hyponatremia is an ominous laboratory sign in the setting of neoplasia. We analyzed the incidence, risk factors, associations, specific interventions and outcomes of severe hyponatremia in a single-center series of children with ALL. The incidence of severe hyponatremia, defined as serum sodium levels below 130 mmol/L on at least 2 of 3 consecutive days, was 11.9%. History of hyponatremia episode is associated with neurologic complications (P=0...
January 5, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28057513/enterolobium-contortisiliquum-is-a-cause-of-acute-ruminal-acidosis-in-sheep
#7
Rayane C Pupin, Paula V Leal, Stephanie C Lima, Gleice Kelli A Melo, Arnildo Pott, Marcelo A Araújo, Claudio S L Barros, Ricardo A A Lemos
The ingestion of pods of Enterolobium contortisiliquum is associated with digestive disturbances, photosensitivity and abortion in domestic ruminants. This experiment was designed to test the hypothesis that digestive disturbances in this toxicosis are really caused by acute ruminal acidosis. Three sheep fed large doses (10-15 g/kg/body weight [bw]) of E. contortisiliquum pods developed ruminal acidosis and were treated with sodium bicarbonate to try to control this metabolic disturbance, thus providing additional evidence of the involvement of ruminal acidosis in the pathogenesis of toxicosis...
January 3, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28056649/taste-quality-confusions-influences-of-age-smoking-ptc-taster-status-and-other-subject-characteristics
#8
Richard L Doty, Jonathan H Chen, Jane Overend
Many persons misidentify the quality of taste stimuli, a phenomenon termed "taste confusion." In this study of 1000 persons, we examined the influences of age, sex, causes of chemosensory disturbances, and genetically determined phenylthiocarbamide (PTC) taster status on taste quality confusions for four tastants (sucrose, citric acid, sodium chloride, caffeine). Overall, sour-bitter confusions were most common (19.3%), followed by bitter-sour (11.4%), salty-bitter (7.3%), salty-sour (7.0%), bitter-salty (3...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/28054989/effects-of-long-term-in-vivo-exposure-to-di-2-ethylhexylphthalate-on-thyroid-hormones-and-the-tsh-tshr-signaling-pathways-in-wistar-rats
#9
Xinwen Dong, Jin Dong, Yue Zhao, Jipeng Guo, Zhanju Wang, Mingqi Liu, Yunbo Zhang, Xiaolin Na
Di-(2-ethylhexyl)phthalate (DEHP) was a widely used chemical with human toxicity. Recent in vivo and in vitro studies suggested that DEHP-exposure may be associated with altered serum thyroid hormones (THs) levels, but the underlying molecular mechanisms were largely unknown. To explore the possible molecular mechanisms, 128 Wistar rats were dosed with DEHP by gavage at 0, 150, 300, and 600 mg/kg/day for 3 months (M) and 6 M, respectively. After exposure, expression of genes and proteins in the thyroid, pituitary, and hypothalamus tissues of rats were analyzed by Q-PCR and western blot, while the sera and urine samples were assayed by radioimmunoassay and ELISA...
January 4, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28035957/in-vivo-assessment-of-clobetasol-propionate-loaded-lecithin-chitosan-nanoparticles-for-skin-delivery
#10
Taner Şenyiğit, Fabio Sonvico, Alessandra Rossi, Işıl Tekmen, Patrizia Santi, Paolo Colombo, Sara Nicoli, Özgen Özer
The aim of this work was to assess in vivo the anti-inflammatory efficacy and tolerability of clobetasol propionate (CP) loaded lecithin/chitosan nanoparticles incorporated into chitosan gel for topical application (CP 0.005%). As a comparison, a commercial cream (CP 0.05% w/w), and a sodium deoxycholate gel (CP 0.05% w/w) were also evaluated. Lecithin/chitosan nanoparticles were prepared by self-assembling of the components obtained by direct injection of soybean lecithin alcoholic solution containing CP into chitosan aqueous solution...
December 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28009309/-modern-approaches-to-correction-of-hypernatremia-in-neurosurgical-patients
#11
D Vassilyev
The article presents the analysis of the intensive therapy through the correction of persistent hypernatremia in neurosurgical patients after removal of brain tumors. The aim of this work was to evaluate the effectiveness of Sterofundin in the framework of complex therapy of hypernatremia in neurosurgical patients after removal of brain tumors. We analyzed the dynamics of the concentrations of sodium, potassium, chorus of the plasma, anion gap and buffer bases in the postoperative period of these patients. For obtaining reliable results, the patients were divided into groups according to the nature of the treatment: Sterofundin and symptomatic correction of hypotonic solution of sodium chloride, saluretic and Verospiron respectively...
November 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27990831/-clinical-evaluation-of-acid-base-status-henderson-hasselbalch-or-stewart-fencl-approach
#12
Karel Matoušovic, Jan Havlín, Otto Schück
Two approaches have been used in clinical evaluation the acid-base status: traditional (bicarbonate-centered) is based on the Henderson-Hasselbalch equation complemented by calculation of the anion gap, and more recent quantitative approach proposed by Stewart and Fencl. The latter method defines the three independent variables, which regulate pH. These include: the difference between the sum of charges carried by strong plasma cations and anions termed the strong ion difference - SID (decrease causes acidosis, and vice versa); the total concentration of the weak non-volatile acids [Atot] (inorganic phosphate and albumin, decrease causes alkalosis and vice versa), and pCO2...
2016: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/27989950/plastic-changes-along-auditory-pathway-during-salicylate-induced-ototoxicity-hyperactivity-and-cf-shifts
#13
Chen Jiang, Bin Luo, Senthilvelan Manohar, Guang-Di Chen, Richard Salvi
High dose of salicylate, the active ingredient in aspirin, has long been known to induce transient hearing loss, tinnitus and hyperacusis making it a powerful experimental tool. These salicylate-induced perceptual disturbances are associated with a massive reduction in the neural output of the cochlea. Paradoxically, the diminished neural output of the cochlea is accompanied by a dramatic increase in sound-evoked activity in the auditory cortex (AC) and several other parts of the central nervous system. Exactly where the increase in neural activity begins and builds up along the central auditory pathway are not fully understood...
October 27, 2016: Hearing Research
https://www.readbyqxmd.com/read/27989333/inherited-pain-syndromes-and-ion-channels
#14
REVIEW
Francis J DiMario
Individuals rely on the perception of pain to avoid injury, to signal disease, and to warn about tissue inflammation and damage. However, the inheritance of inappropriate, extreme, or inadequate pain production is a source of significant human suffering. Substantial progress has been made in our understanding of the genetics and pathophysiology of pain through the study of individuals and families with several specific inherited pain syndromes. These studies have led to the discovery of a number of gene mutations associated with specific ion channel disturbances that produce familial inherited pain sensitivity and insensitivity syndromes...
August 2016: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/27981578/bicarbonate-sensing-in-mouse-cortical-astrocytes-during-extracellular-acid-base-disturbances
#15
Shefeeq M Theparambil, Zinnia Naoshin, Sabrina Defren, Jana Schmaelzle, Tobias Weber, Hans-Peter Schneider, Joachim W Deitmer
Extracellular acid/base status of the mammalian brain undergoes dynamic changes during many physiological and pathological events. Although intracellular pH of astrocytes responds to the alteration of extracellular acid/base changes, mechanisms mediating these changes have remained unresolved. We have previously shown that electrogenic sodium bicarbonate cotransporter, NBCe1, is a high-affinity bicarbonate carrier in cortical astrocytes (Theparambil et al 2014). In the present study, we investigated whether NBCe1 plays a role in bicarbonate sensing in astrocytes, and in determining the pHi responses to extracellular acid/base challenges...
December 16, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27980288/a-case-of-central-pontine-and-extrapontine-myelinolysis-after-surgery-for-a-pituitary-tumor
#16
Takanobu Ishiguro, Tomohiko Ishihara, Yuya Hatano, Takahiro Abe, Takayoshi Shimohata, Masatoyo Nishizawa
A 21-year-old woman underwent surgery for a pituitary tumor. On the 11th postoperative day, blood examination revealed severe hyponatremia, with a serum sodium level of 111 mEq/l, and two days later this increased rapidly to 137 mEq/l. On the 20th postoperative day, the patient developed dysarthria and gait disturbance. Head MRI on the 30th postoperative day demonstrated intense high-signal lesions in the pons and bilateral corpus striatum on FLAIR and DWI, and central pontine and extrapontine myelinolysis was diagnosed...
December 16, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27967227/sodium-and-water-imbalance-after-sellar-suprasellar-and-parasellar-surgery
#17
Zareen Kiran, Aisha Sheikh, Sehrish Nizar Ali Momin, Isra Majeed, Safia Awan, Owais Rashid, Najmul Islam
OBJECTIVES: To report the frequency of sodium and water disturbances (SWD) in patients undergoing sellar, suprasellar and parasellar surgery (SSPS). METHODS: We conducted a cross-sectional retrospective study on 115 patients in the Aga Khan University Hospital after ethical approval. Patients were 16 years old or older undergoing pituitary or sellar surgeries. We collected data on basic sociodemographic characteristics and clinical indication for surgery. We noted laboratory values for serum electrolytes, plasma and urine osmolality, urine sodium and 24-hour fluid balance from immediate postoperative day till discharge and follow up...
December 14, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27919736/effect-of-morin-5-sulfonic-acid-sodium-salt-on-the-expression-of-apoptosis-related-proteins-caspase-3-bax-and-bcl-2-due-to-the-mercury-induced-oxidative-stress-in-albino-rats
#18
Rantham Subramaniam Venkatesan, Abdul Majeeth Mohamed Sadiq
Many environmental contaminants have been reported to disturb the pro-oxidant or antioxidant balance of the cells by inducing oxidative stress. Oxidative stress mediated by the HgCl2 induces DNA, protein and lipid oxidation resulted in necrosis or apoptosis, or both. Currently flavonoids are being emerging topic and reported to have antiviral, anti-inflammatory, anti- tumor and antioxidant activities. Morin is one of the flavonoid protects the cells from oxygen free radical damage and scavenges the free radicals and metals and also heals the injured cells commercially...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27915287/light-induced-oxidation-of-the-telomeric-g4-dna-in-complex-with-zn-ii-tetracarboxymethyl-porphyrin
#19
Artemy D Beniaminov, Roman A Novikov, Olga K Mamaeva, Vladimir A Mitkevich, Igor P Smirnov, Mikhail A Livshits, Anna K Shchyolkina, Dmitry N Kaluzhny
Structure-specific ligands are convenient tools for the recognition, targeting or probing of non-canonical DNA structures. Porphyrin derivatives exhibit a preference for interaction with G-quadruplex (G4) structures over canonical duplex DNA and are able to cause photoinducible damage to nucleic acids. Here, we show that Zn(II) 5,10,15,20-tetrakis(N-carboxymethyl-4-pyridinium)porphyrin ( ZNP1: ) interacts with different conformations of the telomeric sequence d(TAGGG(TTAGGG)3) at submicromolar concentrations without any detectible disturbance of the particular fold...
December 1, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27909620/is-normal-saline-the-best-irrigation-fluid-to-be-used-during-percutaneous-nephrolithotomy-in-renal-failure-patient-a-prospective-randomized-controlled-trial
#20
Bimalesh Purkait, Manoj Kumar, Ankur Bansal, Ashok Kumar Sokhal, Satya Narayan Sankhwar, Kawaljit Singh
OBJECTIVE: Endoscopic procedures like percutaneous nephrolithotomy (PCNL) needs continuous irrigation for better vision and to wash away stone fragments and blood clots. Systemic absorption of irrigation fluids may lead to fluid overload and electrolyte disequilibrium. Renal failure patients are more prone to these electrolyte disturbances. We have evaluated the outcomes of normal saline as irrigation solution to be used in renal failure patient in comparison to distilled water. METHODS: Seventy-six patients with renal calculi were enrolled in this study between September, 2014, and December, 2015...
December 2016: Turkish Journal of Urology
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