keyword
https://read.qxmd.com/read/38157093/sex-specific-associations-of-five-serum-essential-metal-elements-with-thyroid-nodules-in-euthyroid-adults-a-cross%C3%A2-sectional-study
#21
JOURNAL ARTICLE
Qintao Ma, Ying Li, Genfeng Yu, Siyang Liu, Yuqi Jiang, Hualin Duan, Dongmei Wang, Yajun He, Xingying Chen, Nanfang Yao, Xu Lin, Heng Wan, Jie Shen
The association between the serum essential metal elements (magnesium, iron, copper, zinc, and calcium) and thyroid nodules is still inconsistent. The current study aims to investigate the relationship of metal elements with thyroid nodules and their malignant tendency. A total of 6480 Chinese euthyroid adults were included in our study. We collect basic information through questionnaires and medical checkups. We diagnose thyroid nodules by ultrasound and detect serum trace metal concentrations by using an automatic biochemical analyzer...
December 29, 2023: Biological Trace Element Research
https://read.qxmd.com/read/38139974/form-stable-composite-phase-change-materials-based-on-porous-copper-graphene-heterostructures-for-solar-thermal-energy-conversion-and-storage
#22
JOURNAL ARTICLE
Chao Chang, Bo Li, Baocai Fu, Xu Yang, Yulong Ji
Solar-thermal energy conversion and storage technology has attracted great interest in the past few decades. Phase change materials (PCMs), by storing and releasing solar energy, are able to effectively address the imbalance between energy supply and demand, but they still have the disadvantage of low thermal conductivity and leakage problems. In this work, new form-stable solar thermal storage materials by impregnating paraffin PCMs within porous copper-graphene (G-Cu) heterostructures were designed, which integrated high thermal conductivity, high solar energy absorption, and anti-leakage properties...
December 16, 2023: Polymers
https://read.qxmd.com/read/38138643/proteomic-study-of-broiler-plasma-supplemented-with-different-levels-of-copper-and-manganese-from-different-sources
#23
JOURNAL ARTICLE
Renata Aparecida Martins, Andrey Sávio de Almeida Assunção, José Cavalcante Souza Vieira, Leone Campos Rocha, Priscila Michelin Groff Urayama, Marília Afonso Rabelo Buzalaf, José Roberto Sartori, Pedro de Magalhães Padilha
The aim of the present study was to evaluate the differential expression of plasma proteins in broiler chickens supplemented with different sources (sulfates and hydroxychlorides) and levels of copper (15 and 150 mg kg-1 ) and manganese (80 and 120 mg kg-1 ). For this, plasma samples from 40 broiler chickens were used, divided into four experimental groups: S15-80 (15 ppm CuSO4 and 80 ppm MnSO4 ), S150-120 (150 ppm CuSO4 and 120 ppm MnSO4 ), H15-80 (15 ppm Cu(OH)Cl and 80 ppm Mn(OH)Cl), and H150-120 (150 ppm Cu(OH)Cl and 120 ppm Mn(OH)Cl)...
December 18, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38095762/ferroptosis-and-cuproptposis-in-kidney-diseases-dysfunction-of-cell-metabolism
#24
REVIEW
Tingting Chen, Lifei Liang, Yuzhu Wang, Xiaoyu Li, Cheng Yang
Metal ions play an important role in living organisms and are involved in essential physiological activities. However, the overload state of ions can cause excess free radicals, cell damage, and even cell death. Ferroptosis and cuproptosis are specific forms of cell death that are distinct from apoptosis, necroptosis, and other regulated cell death. These unique modalities of cell death, dependent on iron and copper, are regulated by multiple cellular metabolic pathways, including steady-state metal redox treatment mitochondrial activity of lipid, amino acid and glucose metabolism, and various signaling pathways associated with disease...
December 14, 2023: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/38084148/copper-a-scoping-review-for-nordic-nutrition-recommendations-2023
#25
REVIEW
Christine Henriksen, Erik Kristoffer Arnesen
Copper functions as a structural component in many proteins involved in energy and iron metabolism, production of neurotransmitters, formation of connective tissue and endogenous antioxidant defence. Several biochemical indices have been suggested and used to assess copper status, but none of these has been found suitable for the detection of marginal copper deficiency or marginal copper toxicity. Copper imbalances have been linked to the pathogenesis of several chronic inflammatory diseases. During the last decade, a number of meta-analyses and systematic reviews have been published shedding light on the association between copper imbalances and some of these pathologies...
2023: Food & Nutrition Research
https://read.qxmd.com/read/38081392/the-contributions-of-neonatal-inhalation-of-copper-to-air-pollution-induced-neurodevelopmental-outcomes-in-mice
#26
JOURNAL ARTICLE
Janine Cubello, Elena Marvin, Katherine Conrad, Alyssa K Merrill, Jithin V George, Kevin Welle, Brian P Jackson, David Chalupa, Günter Oberdörster, Marissa Sobolewski, Deborah A Cory-Slechta
Exposures to ambient ultrafine particle (UFP) air pollution (AP) during the early postnatal period in mice (equivalent to human third trimester brain development) produce male-biased changes in brain structure, including ventriculomegaly, reduced brain myelination, alterations in neurotransmitters and glial activation, as well as impulsive-like behavioral characteristics, all of which are also features characteristic of male-biased neurodevelopmental disorders (NDDs). The purpose of this study was to ascertain the extent to which inhaled Cu, a common contaminant of AP that is also dysregulated across multiple NDDs, might contribute to these phenotypes...
January 2024: Neurotoxicology
https://read.qxmd.com/read/38066399/nano-mediated-molecular-targeting-in-diagnosis-and-mitigation-of-wilson-disease
#27
REVIEW
Akanksha Chaturvedi, Swapnil Sharma, Rahul Shukla
Wilson disease, a rare genetic disorder resulting from mutations in the ATP7B gene disrupts copper metabolism, leading to its harmful accumulation in hepatocytes, the brain, and other organs. It affects roughly 1 in 30,000 individuals, with 1 in 90 being gene carriers. Beyond gene mutations, the disease involves complex factors contributing to copper imbalance. Ongoing research seeks to unravel intricate molecular pathways, offering fresh insights into the disease's mechanisms. Simultaneously, there is a dedicated effort to develop effective therapeutic strategies...
December 8, 2023: Molecular Neurobiology
https://read.qxmd.com/read/38049232/3d-printed-colorimetric-copper-ion-detection-kit-and-portable-fluorescent-sensing-device-using-smartphone-based-on-ratiometric-fluorescent-probes
#28
JOURNAL ARTICLE
Mengyuan Liu, Hanchuang Zhu, Yikun Fang, Caiyun Liu, Kun Wang, Xiaohui Zhang, Xinke Li, Lixue Ma, Miaohui Yu, Wenlong Sheng, Baocun Zhu
Copper ion (Cu2+ ) is not only a transition metal ion but also a significant environmental pollutant. The imbalance of Cu2+ content will threaten the safety of the environment and even life. The portable detection devices based on ratiometric fluorescent probes have garnered increasing attention and acclaim because of their reliable analysis parameters. Therefore, two Cu2+ ratiometric fluorescent probes (RH-1 and RH-2) were developed, which exhibit pronounced fluorescence changes, high sensitivity, excellent selectivity, and large Stokes shift...
January 15, 2024: Analytica Chimica Acta
https://read.qxmd.com/read/38042003/mir397b-lac2-module-regulates-cadmium-stress-response-by-coordinating-root-lignification-and-copper-homeostasis-in-arabidopsis-thaliana
#29
JOURNAL ARTICLE
Subhash Reddy Gaddam, Ashish Sharma, Prabodh Kumar Trivedi
Non-essential heavy metal cadmium (Cd) is toxic to plants and animals. Cadmium affects plant photosynthesis, respiration, and causes water imbalance and may lead to plant death. Cadmium induces toxicity by interfering with the essential metal copper (Cu) homeostasis, which affects plant nutrition. Though root lignin biosynthesis is positively regulated by Cd stress, the underlying mechanisms promoting lignin accumulation and controlling Cd-induced Cu limitation responses are unclear. Here, we elucidated the role of Cu-responsive microRNA (miR397b) in Arabidopsis thaliana plants for Cd stress by targeting the LACCASE2 (LAC2) gene...
November 28, 2023: Journal of Hazardous Materials
https://read.qxmd.com/read/38037913/insights-into-the-role-of-copper-in-neurodegenerative-diseases-and-the-therapeutic-potential-of-natural-compounds
#30
JOURNAL ARTICLE
Guangcheng Zhong, Xinyue Wang, Jiaqi Li, Zhouyuan Xie, Qiqing Wu, Jiaxin Chen, Yiyun Wang, Ziying Chen, Xinyue Cao, Tianyao Li, Jinman Liu, Qi Wang
Neurodegenerative diseases encompass a collection of neurological disorders originating from the progressive degeneration of neurons, resulting in the dysfunction of neurons. Unfortunately, effective therapeutic interventions for these diseases are presently lacking. Copper (Cu), a crucial trace element within the human body, assumes a pivotal role in various biological metabolic processes, including energy metabolism, antioxidant defense, and neurotransmission. These processes are vital for the sustenance, growth, and development of organisms...
November 15, 2023: Current Neuropharmacology
https://read.qxmd.com/read/38036945/batch-experimental-studies-and-statistical-modeling-for-the-effective-removal-of-tetracycline-from-wastewater-using-bimetallic-zn-cu-metal-organic-framework-hydrogel-composite-beads
#31
JOURNAL ARTICLE
Harshita Laddha, Priya Sharma, Neha Balaji Jadhav, Md Zainul Abedeen, Ragini Gupta
Antimicrobial resistance (AMR) is on an upsurge as more and more broad-spectrum antibiotics are being used haphazardly, resulting in imbalances in the ecosystem and disrupting common/systematic clinical protocols. To combat this issue, metal-organic framework embedded zinc-copper-benzenedicarboxylate@calcium alginate composite beads (Zn-Cu-BDC@CA CBs) were synthesized and utilized for the adsorption of tetracycline (TC) from water. The surface morphology, presence of functional groups, surface area, and thermal stability of Zn-Cu-BDC@CA CBs were evaluated by field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET), and thermal gravimetric analysis (TGA), respectively...
November 30, 2023: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38023234/cuproptosis-emerging-biomarkers-and-potential-therapeutics-in-cancers
#32
REVIEW
Min Wang, Lianwen Zheng, Shuai Ma, Ruixin Lin, Jiahui Li, Shuli Yang
The sustenance of human life activities depends on copper, which also serves as a crucial factor for vital enzymes. Under typical circumstances, active homeostatic mechanisms keep the intracellular copper ion concentration low. Excess copper ions cause excessive cellular respiration, which causes cytotoxicity and cell death as levels steadily rise above a threshold. It is a novel cell death that depends on mitochondrial respiration, copper ions, and regulation. Cuproptosis is now understood to play a role in several pathogenic processes, including inflammation, oxidative stress, and apoptosis...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37996893/a-review-of-nitric-oxide-and-oxidative-stress-in-typical-ovulatory-women-and-in-the-pathogenesis-of-ovulatory-dysfunction-in-pcos
#33
REVIEW
Awoniyi O Awonuga, Olivia G Camp, Husam M Abu-Soud
Polycystic ovary syndrome (PCOS) is a heterogeneous functional endocrine disorder associated with a low-grade, chronic inflammatory state. Patients with PCOS present an increased risk of metabolic comorbidities and often menstrual dysregulation and infertility due to anovulation and/or poor oocyte quality. Multiple mechanisms including oxidative stress and low-grade inflammation are believed to be responsible for oocyte deterioration; however, the influence of nitric oxide (NO) insufficiency in oocyte quality and ovulatory dysfunction in PCOS is still a matter for debate...
November 23, 2023: Reproductive Biology and Endocrinology: RB&E
https://read.qxmd.com/read/37993046/tissue-specific-toxic-effects-of-nano-copper-on-zebrafish
#34
JOURNAL ARTICLE
Haiqiang Liu, Yanli Xu, Yuqiong Sun, Haodi Wu, Jing Hou
Understanding the behavior and potential toxicity of copper nanoparticles (nano-Cu) in the aquatic environment is a primary way to assess their environmental risks. In this study, RNA-seq was performed on three different tissues (gills, intestines, and muscles) of zebrafish exposed to nano-Cu, to explore the potential toxic mechanism of nano-Cu on zebrafish. The results indicated that the toxic mechanism of nano-Cu on zebrafish was tissue-specific. Nano-Cu enables the CB1 receptor of the presynaptic membrane of gill cells to affect short-term synaptic plasticity or long-term synaptic changes (ECB-LTD) through DSI and DSE, causing dysfunction of intercellular signal transmission...
November 20, 2023: Environmental Research
https://read.qxmd.com/read/37958705/common-and-trace-metals-in-alzheimer-s-and-parkinson-s-diseases
#35
REVIEW
Julia Doroszkiewicz, Jakub Ali Farhan, Jan Mroczko, Izabela Winkel, Maciej Perkowski, Barbara Mroczko
Trace elements and metals play critical roles in the normal functioning of the central nervous system (CNS), and their dysregulation has been implicated in neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). In a healthy CNS, zinc, copper, iron, and manganese play vital roles as enzyme cofactors, supporting neurotransmission, cellular metabolism, and antioxidant defense. Imbalances in these trace elements can lead to oxidative stress, protein aggregation, and mitochondrial dysfunction, thereby contributing to neurodegeneration...
October 29, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37929055/evaluation-of-trace-elements-levels-and-construction-of-auxiliary-prediction-model-in-patients-with-diabetes-ketoacidosis-in-type-1-diabetes
#36
JOURNAL ARTICLE
Jiatong Chai, Zeyu Sun, Qi Zhou, Jiancheng Xu
BACKGROUND: Trace elements play an important role in reflecting physical metabolic status, but have been rarely evaluated in diabetes ketoacidosis (DKA). Since clinical biochemical parameters are the first-line diagnostic data mastered by clinical doctors and DKA has a rapid progression, it is crucial to fully utilize clinical data and combine innovative parameters to assist in assessing disease progression. The aim of this study was to evaluate the levels of trace elements in DKA patients, followed by construction of predictive models combined with the laboratory parameters...
2023: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/37926172/association-of-prenatal-essential-metal-exposure-with-newborn-mitochondrial-dna-copy-number-results-from-a-birth-cohort-study
#37
JOURNAL ARTICLE
Jianing Bi, Lulu Song, Mingyang Wu, Qing Liu, Luli Xu, Gaojie Fan, Zhongqiang Cao, Chao Xiong, Youjie Wang
Imbalance or deficiencies of essential metals can lead to oxidative stress, that can damage mitochondrial DNA (mtDNA) molecule. Knowledge on effects of exposure to essential metals and their mixture remains limited. We aimed to evaluate individual and joint associations of prenatal essential metals with neonatal mtDNA copy number. We recruited 746 mother-newborn pairs from a birth cohort study conducted in Wuhan City, China, and collected trimester-specific urine and cord blood samples. We measured the concentrations of seven urinary essential metals, include zinc (Zn), iron (Fe), selenium (Se), cobalt (Co), manganese (Mn), copper (Cu), and chromium (Cr), using inductively coupled plasma mass spectrometry, and measured cord blood mtDNA copy number using real-time quantitative polymerase chain reaction...
November 4, 2023: Reproductive Toxicology
https://read.qxmd.com/read/37878665/blood-biomarkers-in-alzheimer-s-disease
#38
JOURNAL ARTICLE
Pravat K Mandal, Joseph C Maroon, Arun Garg, Narendra Kumar Arora, Rishu Bansal, Aditi Kaushik, Avantika Samkaria, Gayathri Kumaran, Yashika Arora
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that affects millions of people worldwide. The characteristic pathological manifestation of AD includes the deposition of extracellular insoluble β amyloid plaques and intracellular neurofibrillary tangles formed from hyperphosphorylated tau protein. Cost effective and minimally invasive peripheral blood-based biomarkers are critical for early AD diagnosis. Currently, the plasma based two fraction of β amyloid peptide ratio (Aβ42/40) and phosphorylated tau (p-tau) are considered as blood-based biomarkers for AD diagnosis...
October 25, 2023: ACS Chemical Neuroscience
https://read.qxmd.com/read/37870679/the-role-of-astrocytic-mitochondria-in-the-pathogenesis-of-brain-ischemia
#39
REVIEW
Ling-Yan Zhang, Yu-Yan Hu, Xi-Yun Liu, Xiao-Yu Wang, Shi-Chao Li, Jing-Ge Zhang, Xiao-Hui Xian, Wen-Bin Li, Min Zhang
The morbidity rate of ischemic stroke is increasing annually with the growing aging population in China. Astrocytes are ubiquitous glial cells in the brain and play a crucial role in supporting neuronal function and metabolism. Increasing evidence shows that the impairment or loss of astrocytes contributes to neuronal dysfunction during cerebral ischemic injury. The mitochondrion is increasingly recognized as a key player in regulating astrocyte function. Changes in astrocytic mitochondrial function appear to be closely linked to the homeostasis imbalance defects in glutamate metabolism, Ca2+ regulation, fatty acid metabolism, reactive oxygen species, inflammation, and copper regulation...
October 23, 2023: Molecular Neurobiology
https://read.qxmd.com/read/37866064/protective-role-of-fullerenol-and-arginine-c-60-fullerene-against-copper-toxicity-in-cucumber
#40
JOURNAL ARTICLE
Nikolai P Bityutskii, Kirill L Yakkonen, Yulia M Napolskikh, Danil Pampur, Gleb O Yuriev, Konstantin N Semenov, Dmitry G Letenko
Copper (Cu), when in excess, is one of the most toxic and hazardous metals to all living organisms, including plants. Engineered nanomaterials have the potential for increasing crop protection. However, the protective role of fullerenes (carbon-based nanoparticles with wide application in various areas) against Cu toxicity in plants is, so far, understudied. The present study investigated whether fullerenes can potentially alleviate Cu toxicity in plants (Cucumis sativus L.). Two water-soluble fullerene C60 derivatives were examined: fullerenol [C60 (OH)22-24 ] and arginine-functionalized fullerene [C60 (C6 H13 N4 O2 )8 H8 ], under controlled conditions using hydroponics...
October 16, 2023: Plant Physiology and Biochemistry: PPB
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