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Copper imbalance

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https://www.readbyqxmd.com/read/29705531/copper-and-arsenic-induced-oxidative-stress-and-immune-imbalance-are-associated-with-activation-of-heat-shock-proteins-in-chicken-intestines
#1
Yu Wang, Hongjing Zhao, Juanjuan Liu, Yizhi Shao, Jinglun Li, Liyang Luo, Mingwei Xing
Arsenic and copper, two ubiquitous pollutants, can be oxidative stress inducers when organisms are heavy or chronically exposed, causing adverse effects on digestion and absorption function, resulting in potential losses to poultry husbandry. The present study examined the effects of arsenic trioxide (30 mg/kg)- and copper sulfate (300 mg/kg)-mixed foods, administered alone or in combination for 12 weeks, on various biochemical indices of oxidative stress and immunity in the small intestines of Hy-line chickens...
April 26, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29618936/trace-elements-and-oxidative-stress-in-children-with-type-1-diabetes-mellitus
#2
Ashgan Abdalla Alghobashy, Usama M Alkholy, Mohamed A Talat, Nermin Abdalmonem, Ahmed Zaki, Ihab A Ahmed, Randa H Mohamed
Background: The early imbalances of trace elements in type 1 diabetes (T1D) may cause disturbance of glucose metabolism and more oxidative stress that may enhance the development of insulin resistance and diabetic complications. We aim to evaluate the serum level of selenium (Se), zinc (Zn), magnesium (Mg), and copper (Cu), the degree of oxidative stress and evaluate their relations to glycemic control in children with T1D. Methods: A case-control study which included 100 diabetic children and 40 healthy children age, sex, and ethnicity-matched as a control group...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29617867/weaning-disrupts-intestinal-antioxidant-status-impairs-intestinal-barrier-and-mitochondrial-function-and-triggers-mitophagy-in-piglets
#3
S T Cao, C C Wang, H Wu, Q H Zhang, L F Jiao, C H Hu
In the present study, we investigated the influence of weaning on antioxidant status, intestinal integrity, mitochondrial function, and the mitophagy level in piglets (weaned at 21 d) during the 1 wk after weaning. The redox status was measured by antioxidant enzymes activities, related genes expression, and malondialdehyde (MDA) content in jejunum. The intestinal barrier function was assessed by the Ussing chamber and expression of tight junction proteins in the jejunum. The function of intestine mitochondria was measured by mitochondrial DNA (mtDNA) content and activities of mitochondria oxidative phosphorylation complexes...
April 3, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29616754/venous-insufficiency-differences-in-the-content-of-trace-elements-a-preliminary-report
#4
Agnieszka Rusak, Ewa Karuga-Kuźniewska, Benita Wiatrak, Maria Szymonowicz, Mateusz Stolarski, Małgorzata Radwan-Oczko, Rafał J Wiglusz, Paweł Pohl, Zbigniew Rybak
BACKGROUND: Venous insufficiency is still a serious clinical problem. The exact cause and molecular mechanisms of this disease are still unknown. In this study, we try to identify whether there is a difference in the level of trace elements between healthy and pathological veins. Our results show that insufficient veins have different levels of some trace elements: magnesium, calcium, manganese, and silicon compared to control samples. This study could lead to a better understanding of the molecular causes of venous insufficiency and may help to develop better methods of treatment...
April 4, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29615045/a-common-mechanism-explains-the-induction-of-aerobic-fermentation-and-adaptive-antioxidant-response-in-phaffia-rhodozyma
#5
Anahí Martínez-Cárdenas, Cipriano Chávez-Cabrera, Jazmín M Vasquez-Bahena, Luis B Flores-Cotera
BACKGROUND: Growth conditions that bring about stress on Phaffia rhodozyma cells encourage the synthesis of astaxanthin, an antioxidant carotenoid, which protects cells against oxidative damage. Using P. rhodozyma cultures performed with and without copper limitation, we examined the kinetics of astaxanthin synthesis along with the expression of asy, the key astaxanthin synthesis gene, as well as aox, which encodes an alternative oxidase protein. RESULTS: Copper deficiency had a detrimental effect on the rates of oxygen consumption and ethanol reassimilation at the diauxic shift...
April 3, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29555591/keto-enol-based-modification-on-piperlongumine-to-generate-a-potent-cu-ii-ionophore-that-triggers-redox-imbalance-and-death-of-hepg2-cells
#6
Fang Dai, Cui-Hong Yuan, Yuan Ji, Yu-Ting Du, Xia-Zhen Bao, Ling-Xi Wu, Xiao-Ling Jin, Bo Zhou
Altered redox status including higher levels of copper in cancer cells than in normal cells inspired many researchers to develop copper ionophores targeting this status. We have recently found that flavon-3-ol (3-HF) works as a potent Cu(II) ionophore by virtue of its keto-enol moiety. To further emphasize the significance of this moiety for developing Cu(II) ionophores, we herein designed a β-diketo analog of piperlongumine, PL-I, characterized by the presence of high proportion of the keto-enol form in dimethylsulfoxide and chloroform, and identified its keto-enol structure by NMR and theoretical calculations...
March 16, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29536063/metallome-evolution-in-ageing-c-elegans-and-a-copper-stable-isotope-perspective
#7
Lucie Sauzéat, Anne Laurençon, Vincent Balter
Ageing is accompanied by important chemical deregulations resulting in bodily metal imbalances. The way and extent to which these deregulations are associated with ageing processes are however poorly understood and their use as potential biomarkers of ageing has not been investigated. In this study, we report whole-body elementary concentrations and copper and zinc isotopic compositions of Caenorhabditis elegans in ageing wild type (i.e.'normal'-lived) and mutant (i.e. short and long-lived) strains. We show that the strains are characterized by different levels of mutation-related variations such as in phosphorus and magnesium as well as in zinc isotopic composition...
March 1, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29524632/copper-and-ceruloplasmin-dyshomeostasis-in-serum-and-cerebrospinal-fluid-of-multiple-sclerosis-subjects
#8
L De Riccardis, A Buccolieri, M Muci, E Pitotti, F De Robertis, G Trianni, D Manno, M Maffia
Although many studies have been carried out in order to understand the implication of copper (Cu) in the pathogenesis of multiple sclerosis (MS), the exact role that this metal plays in the disease is not still clear. Because of the lack of information in this subject, the present study compared the serum and cerebrospinal (CSF) levels of copper in MS patients in respect to a control group, matched for age and sex, finding a significant increase of metal concentrations, in both biological fluids of MS subjects...
May 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29328033/-elemental-status-of-patients-with-various-forms-of-vitiligo
#9
N I Tsiskarishvili, A Katsitadze, N V Tsiskarishvili, I Charischarishvili
Vitiligo is a multifactorial disease in which, in each specific case of its manifestation, different mechanisms of its pathogenesis and different levels of melanin formation in the skin can be involved. Skin is one of the most metabolically active organs. Carrying out a number of vital functions (barrier, protective, respiratory, excretory, metabolic, immune, etc.), it needs microelementss. Of the 92 naturally occurring chemical elements, 81 are found in the human body. Lack of the vital elements, leads to the emergence of diseases, which are based on deficiency, excess or imbalance of micro- and macroelements in the body...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29285723/the-divalent-elements-changes-in-early-stages-of-chronic-kidney-disease
#10
Wan-Ju Kung, Ching-Tang Shih, Chien-Hung Lee, Ching-Chiang Lin
As the glomerular filtration rate (GFR) decreases, it can cause imbalance in some divalent elements. These imbalances can cause increased oxidative stress in patients with renal impairment. The aim of present study was to investigate the changes of these divalent elements with CKD progression. One hundred and ninety-four patients with chronic kidney diseases (CKD) were divided into five stages, stage 1, 2, 3a, 3b, 4, and were recruited into this study. The divalent elements, calcium, magnesium, phosphorus, as well as iron, zinc, and copper were determined in clinical chemistry analyzer...
December 28, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29236516/trace-minerals-intake-risks-and-benefits-for-cardiovascular-health
#11
Noushin Mohammadifard, Karin H Humphries, Carolyn Gotay, Guillermo Mena-Sánchez, Jordi Salas-Salvadó, Ahmad Esmaillzadeh, Andrew Ignaszewski, Nizal Sarrafzadegan
Minerals play a major role in regulating cardiovascular function. Imbalances in electrolyte minerals are frequent and potentially hazardous occurrences that may lead to the development of cardiovascular diseases (CVDs). Transition metals, such as iron, zinc, copper and selenium, play a major role in cell metabolism. However, there is controversy over the effects of dietary and supplemental intake of these metals on cardiovascular risk factors and events. Since their pro-oxidant or antioxidant functions can have different effects on cardiovascular health...
December 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29228677/copper-or-and-arsenic-induce-oxidative-stress-cascaded-nuclear-factor-kappa-b-dependent-inflammation-and-immune-imbalance-trigging-heat-shock-response-in-the-kidney-of-chicken
#12
Yu Wang, Hongjing Zhao, Yizhi Shao, Juanjuan Liu, Jinglun Li, Mingwei Xing
Excessive amount of copper (Cu) and inorganic arsenic (iAs) coexists in drinking water in many regions, this is associated with high risk of nephropathy, defined as chronic structural and functional disorders of the kidney. However, the underlying mechanisms are not well understood. In this study, a total of 72 day-old Hy-line chickens were exposed to 300 mg/kg copper sulphate or/and 30 mg/kg arsenic trioxide for 12 weeks. Indicators of oxidative stress, inflammation and heat shock proteins (HSPs) production were analyzed in kidney...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29177784/how-tapeworm-infection-and-consumption-of-a-cd-and-zn-hyperaccumulating-plant-may-affect-cu-fe-and-mn-concentrations-in-an-animal-a-plant-consumer-and-tapeworm-host
#13
Ivana Jankovská, Vladislav Sloup, Jiřina Száková, Jan Magdálek, Stanislava Nechybová, Pavla Peřinková, Iva Langrová
This study evaluated the effects of a hyperaccumulator plant (Arabidopsis halleri), containing surplus of cadmium (Cd) and zinc (Zn) and being an admixture to the rat feed, on concentrations of copper (Cu), iron (Fe), and manganese (Mn) in the tissues of experimental rats infected/uninfected with the tapeworm (Hymenolepis diminuta). Male Wistar rats were divided into three groups (00, P0, and PT); the P0 and PT animals were fed a standard mixture for rats (ST-1) supplemented with the plant A. halleri at a weekly Zn and Cd dosage of 123 and 1 mg, respectively...
February 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29116533/effect-of-probiotics-on-the-basis-of-bacillus-subtilis-and-bifidobacterium-longum-on-the-biochemical-parameters-of-the-animal-organism
#14
Olga Vilorievna Kvan, Irina Aleksandrovna Gavrish, Svyatoslav Valeryevich Lebedev, Anastasia Mickhailovna Korotkova, Elena Petrovna Miroshnikova, Victoria Alekseevna Serdaeva, Artem Vladimirovich Bykov, Natalia Olegovna Davydova
For the purpose of safe modulation of the intestinal microflora, probiotics have been increasingly used in recent years. In the present work, the effect of the probiotic sporobacterin (Bacillus subtilis 534) (I group) and soybean-bifidum (Bifidobacterium longum) (II group) on male rats of the Wistar line was evaluated. In assessing nonspecific immunity in vitro, there was an increase in the level of baseline level in the first and second groups (by 8.3 and 12.2% more control). The influence of probiotic preparations on the intestinal normoflora was assessed using PCR...
January 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29114205/biometal-dyshomeostasis-and-toxic-metal-accumulations-in-the-development-of-alzheimer-s-disease
#15
REVIEW
Yong Li, Qian Jiao, Huamin Xu, Xixun Du, Limin Shi, Fengju Jia, Hong Jiang
Biometal dyshomeostasis and toxic metal accumulation are common features in many neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease, and Huntington's disease. The neurotoxic effects of metal imbalance are generally associated with reduced enzymatic activities, elevated protein aggregation and oxidative stress in the central nervous system, in which a cascade of events lead to cell death and neurodegeneration. Although the links between biometal imbalance and neurodegenerative disorders remain elusive, a major class of endogenous proteins involved in metal transport has been receiving increasing attention over recent decades...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29113209/prognostic-value-of-copper-transporter-1-expression-in-patients-with-clear-cell-renal-cell-carcinoma
#16
Yu Xia, Li Liu, Qi Bai, Qilai Long, Jiajun Wang, Wei Xi, Jiejie Xu, Jianming Guo
Clear cell renal cell carcinoma (ccRCC) features a Von Hippel-Lindau mutation, associated with a hypoxia-inducible factor (HIF) imbalance. Copper transporter 1 (CTR1) may also promote tumor progression through the modulation of the HIF pathway by copper. Therefore, the present study explored the prognostic effect of tumor CTR1 expression in patients with ccRCC. A total of 293 patients with ccRCC that underwent nephrectomy were retrospectively enrolled. CTR1 expression was assessed by immunohistochemistry, and its association with clinicopathological features and prognosis were evaluated...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29109370/olive-olea-europaea-l-biophenols-a-nutriceutical-against-oxidative-stress-in-sh-sy5y-cells
#17
Syed Haris Omar, Philip G Kerr, Christopher J Scott, Adam S Hamlin, Hassan K Obied
Plant biophenols have been shown to be effective in the modulation of Alzheimer's disease (AD) pathology resulting from free radical-induced oxidative stress and imbalance of the redox chemistry of transition metal ions (e.g., iron and copper). On the basis of earlier reported pharmacological activities, olive biophenols would also be expected to have anti-Alzheimer's activity. In the present study, the antioxidant activity of individual olive biophenols (viz. caffeic acid, hydroxytyrosol, oleuropein, verbascoside, quercetin, rutin and luteolin) were evaluated using superoxide radical scavenging activity (SOR), hydrogen peroxide (H₂O₂) scavenging activity, and ferric reducing ability of plasma (FRAP) assays...
October 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29103113/testicular-toxicity-and-sperm-quality-following-copper-exposure-in-wistar-albino-rats-ameliorative-potentials-of-l-carnitine
#18
Maurya Khushboo, Meesala Krishna Murthy, Maibam Sunita Devi, Sanasam Sanjeev, Kalibulla Syed Ibrahim, Nachimuthu Senthil Kumar, Vikas Kumar Roy, Guruswami Gurusubramanian
Copper is a persistent toxic and bio-accumulative heavy metal of global concern. Continuous exposure of copper compounds of different origin is the most common form of copper poisoning and in turn adversely altering testis morphology and function and affecting sperm quality. L-carnitine has a vital role in the spermatogenesis, physiology of sperm, sperm production and quality. This study was designed to examine whether the detrimental effects of long-term copper consumption on sperm quality and testis function of Wistar albino rat could be prevented by L-carnitine therapy...
January 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29100755/total-flavonoid-extract-from-dracoephalum-moldavica-l-attenuates-%C3%AE-amyloid-induced-toxicity-through-anti-amyloidogenesic-and-neurotrophic-pathways
#19
Qing-Shan Liu, Hai-Lun Jiang, Yu Wang, Lin-Lin Wang, Jun-Xia Zhang, Cheng-Hui He, Shuai Shao, Tian-Tai Zhang, Jian-Guo Xing, Rui Liu
AIMS: Alzheimer's disease (AD) is an incurable neurodegenerative disorder characterized by global cognitive impairment that involves accumulation of amyloid-beta peptides (Aβ) in the brain. Herbal approaches can be used as alternative medicines to slow the progression of AD. This study aimed to determine the beneficial effects and potential underlying mechanisms of total flavonoid extract from Dracoephalum moldavica L. (TFDM) for attenuating Alzheimer-related deficits induced by Aβ...
January 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29035754/regulation-of-autophagy-factors-by-oxidative-stress-and-cardiac-enzymes-imbalance-during-arsenic-or-and-copper-induced-cardiotoxicity-in-gallus-gallus
#20
Siwen Li, Hongjing Zhao, Yu Wang, Yizhi Shao, Bangyi Wang, Yulong Wang, Mingwei Xing
Basal autophagy has an indispensable role in the functioning and maintenance of cardiac geometry under physiological conditions. Recently, increasing evidence has demonstrated that arsenic (As)/copper (Cu) play important roles in the autophagy of the heart. The current study was to evaluate whether oxidative damage by As or/and Cu was correlated with autophagy through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in the heart of birds. Arsenic trioxide (30mg/kg) or/and cupric sulfate (300mg/kg) were administered in a basal diet to male Hy-line chickens (one-day-old) for 12 weeks...
February 2018: Ecotoxicology and Environmental Safety
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