keyword
MENU ▼
Read by QxMD icon Read
search

Ms thyroid

keyword
https://www.readbyqxmd.com/read/27904656/the-berlin-treatment-algorithm-recommendations-for-tailored-innovative-therapeutic-strategies-for-multiple-sclerosis-related-fatigue
#1
REVIEW
Christian Veauthier, Helge Hasselmann, Stefan M Gold, Friedemann Paul
More than 80% of multiple sclerosis (MS) patients suffer from fatigue. Despite this, there are few therapeutic options and evidence-based pharmacological treatments are lacking. The associated societal burden is substantial (MS fatigue is a major reason for part-time employment or early retirement), and at least one out of four MS patients view fatigue as the most burdensome symptom of their disease. The mechanisms underlying MS-related fatigue are poorly understood, and objective criteria for distinguishing and evaluating levels of fatigue and tiredness have not yet been developed...
2016: EPMA Journal
https://www.readbyqxmd.com/read/27861937/electrophysiological-identification-of-nonrecurrent-laryngeal-nerves
#2
Emad Kandil, Muhammad A Anwar, Jeremy Bamford, Rizwan Aslam, Gregory W Randolph
OBJECTIVES/HYPOTHESIS: The nonrecurrent laryngeal nerve (NRLN) is a common anatomic variation of the right recurrent laryngeal nerve (RLN), which has been associated with an increased risk of injury during thyroid and parathyroid surgery. We suggest that early successful identification using intraoperative nerve monitoring (IONM) and preservation of this variant will help the surgeon to avoid injury to this nerve. Our objective was to examine the electrophysiological parameters of the NRLN and the efficacy of IONM for successful identification of the NRLN...
November 15, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27833448/a-possible-link-between-the-epstein-barr-virus-infection-and-autoimmune-thyroid-disorders
#3
REVIEW
Anna Dittfeld, Katarzyna Gwizdek, Marek Michalski, Romuald Wojnicz
The Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the Herpesviridae virus family. EBV infection can cause infectious mononucleosis (IM) in the lytic phase of EBV's life cycle. Past EBV infection is associated with lymphomas, and may also result in certain allergic and autoimmune diseases. Although potential mechanisms of autoimmune diseases have not been clearly elucidated, both genetic and environmental factors, such as infectious agents, are considered to be responsible for their development...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27831763/thyroid-patient-salivary-radioiodine-transit-and-dysfunction-assessment-using-chewing-gums
#4
Demetrios Okkalides
Radiation-induced salivary gland dysfunction is the most frequent side-effect of I-131 thyroid therapy. Here, a novel saliva sampling method with ordinary chewing gums administered to the patients at appropriate time intervals post-treatment (TIPT) was used to relate this effect to chewing gum saliva activity (CGSA) content. Saliva samples were acquired after the oral administration of prescribed I-131 activity (radioactivity administered [RA]) to 19 differentiated thyroid cancer (DTC) and 16 hyperthyroidism patients of the radioisotope unit (RIU) during 2014 and 2015...
November 2016: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27812786/the-functional-role-of-the-pharyngeal-plexus-in-vocal-cord-innervation-in-humans
#5
Mehmet Uludag, Nurcihan Aygun, Adnan Isgor
Classical understanding of the function of the pharyngeal plexus in humans is that it relies on both motor branches for innervation of the majority of pharyngeal muscles and sensory branches for the pharyngeal wall sensation. To date there has been no reported data on the role of the pharyngeal plexus in vocal cord innervation. The aim of this study is to evaluate whether or not the plexus pharyngeus contributes to the innervation of the vocal cords. One hundred twenty-five sides from 79 patients (59 female, 20 male) undergoing thyroid surgery with intraoperative neuromonitoring were prospectively evaluated...
November 3, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27782388/ambient-ionization-and-faims-mass-spectrometry-for-enhanced-imaging-of-multiply-charged-molecular-ions-in-biological-tissues
#6
Clara Leigh Feider, Natalia Elizondo, Livia S Eberlin
Ambient ionization mass spectrometry imaging (MSI) has been increasingly used to investigate the molecular distribution of biological tissue samples. Here, we report the integration and optimization of desorption electrospray ionization (DESI) and liquid-microjunction surface sampling probe (LMJ-SSP), and a chip-based high-field asymmetric waveform ion mobility spectrometry (FAIMS) device to image metabolites, lipids, and proteins in biological tissue samples. Optimized FAIMS parameters for specific molecular classes enabled semi-targeted detection of multiply-charged molecular species at enhanced signal-to-noise ratios (S/N), improved visualization of spatial distributions, and most importantly, allowed detection of species which were otherwise unseen by ambient ionization MSI alone...
October 26, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27737898/diagnosis-of-endocrine-disease-how-reliable-are-free-thyroid-and-total-t3-hormone-assays
#7
REVIEW
Kerry J Welsh, Steven J Soldin
Hypothyroidism is a very common disorder worldwide, for which the usual treatment is monotherapy with levothyroxine (L-T4). However, a number of patients treated with L-T4 continue to report symptoms of hypothyroidism despite seemingly normal levels of thyroid-stimulating hormone (TSH), free-T3 (FT3) and free-T4 (FT4) measured by immunoassay. This review summarizes the limitations of the immunoassays commonly used to measure thyroid hormone levels and emphasizes the advantages of the role of liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
December 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27736322/thyroglobulin-liquid-chromatography-tandem-mass-spectrometry-has-a-low-sensitivity-for-detecting-structural-disease-in-patients-with-anti-thyroglobulin-antibodies
#8
Umal Azmat, Kyle Porter, Leigha Senter, Matthew D Ringel, Fadi Nabhan
BACKGROUND: Thyroglobulin (Tg) measurement in patients with positive anti-thyroglobulin antibodies (anti-Tg Abs) is not reliable. Tg measurement using Liquid Chromatography Tandem Mass Spectrometry (LC/MS) may be useful in this setting Methods: This is a retrospective study with the objective to determine the accuracy of Tg-LC/MS in patients with thyroid cancer with anti-Tg Abs. We evaluated all patients with follicular cell-derived thyroid cancer (TC) who had thyroglobulin measured using LC/MS assay from 11/1/2013-11/7/2014...
October 13, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27732086/a-nonradioactive-dehal-assay-for-testing-substrates-inhibitors-and-monitoring-endogenous-activity
#9
Kostja Renko, Carolin S Hoefig, Corinne Dupuy, Lisbeth Harder, Christian Schwiebert, Josef Köhrle, Lutz Schomburg
Iodotyrosine deiodinase (DEHAL1) is a crucial enzyme in iodine homeostasis. Unbound mono- and diiodotyrosines are indispensable byproducts of thyroid hormone biosynthesis. Their iodine needs to be recovered to avoid iodine deficiency, as observed in genetic defects in DEHAL1. Despite its importance, the enzyme is rarely studied. The deiodination process can be monitored by radioactive tracers or via techniques involving mass spectrometry. However, isotope-labeled molecules are expensive, not always commercially available, and their use is legally restricted, whereas mass spectrometry requires sophisticated, costly, and sensitive instrumentation...
December 2016: Endocrinology
https://www.readbyqxmd.com/read/27729057/takotsubo-like-syndrome-triggered-by-fludrocortisone-overdose-for-addison-s-disease-a-case-report
#10
Radu Campean, Matthias Hasun, Claudia Stöllberger, Johannes Bucher, Josef Finsterer, Christoph Schnack, Franz Weidinger
BACKGROUND: Reversible left ventricular dysfunction, also termed Takotsubo cardiomyopathy, is rarely reported in Addison's disease after initiation of hormone replacement therapy. The pathogenesis of this cardiomyopathy is unknown. CASE PRESENTATION: A 41-year-old white woman with a history of autoimmune Hashimoto thyroiditis diagnosed 3 years earlier and acute adrenal insufficiency diagnosed 3 weeks earlier presented with new onset of heart failure New York Heart Association class IV, which had started shortly after initiation of hormone replacement therapy with hydrocortisone 20 mg/day and fludrocortisone 0...
October 12, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27676653/a-novel-role-for-flotillin-containing-lipid-rafts-in-negative-feedback-regulation-of-thyroid-specific-gene-expression-by-thyroglobulin
#11
Yuqian Luo, Takeshi Akama, Akiko Okayama, Aya Yoshihara, Mariko Sue, Kenzaburo Oda, Moyuru Hayashi, Yuko Ishido, Hisashi Hirano, Naoki Hiroi, Ryohei Katoh, Koichi Suzuki
BACKGROUND: Thyroglobulin (Tg) stored in thyroid follicles regulates follicular function in thyroid hormone (TH) synthesis by suppressing thyroid-specific gene expression in a concentration-dependent manner. Thus, Tg is an intrinsic negative-feedback regulator that can restrain the effect of thyroid stimulating hormone (TSH) in the follicle. However, the underlying mechanisms by which Tg exerts its prominent autoregulatory effect following recognition by thyrocytes remains unclear. METHODS: To identify potential proteins that recognize and interact with Tg, mass spectrometry (MS) was used to analyze immunoprecipitated Tg-bound proteins derived from Tg-treated rat thyroid FRTL-5 cells...
September 27, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27659048/cardiolipins-are-biomarkers-of-mitochondria-rich-thyroid-oncocytic-tumors
#12
Jialing Zhang, Wendong Yu, Seung Ryu, John Lin, Gerardo Buentello, Robert Tibshirani, James Suliburk, Livia Schiavinato Eberlin
Oncocytic tumors are characterized by an excessive eosinophilic, granular cytoplasm due to aberrant accumulation of mitochondria. Mutations in mitochondrial DNA occurs in oncocytic thyroid tumors, but there is no information about their lipid composition which might reveal candidate theranostic molecules. Here we used desorption electrospray ionization mass spectrometry (DESI-MS) to image and chemically characterize the lipid composition of oncocytic thyroid tumors, as compared to non-oncocytic thyroid tumors and normal thyroid samples...
September 22, 2016: Cancer Research
https://www.readbyqxmd.com/read/27650974/thyronamines-and-derivatives-physiological-relevance-pharmacological-actions-and-future-research-directions
#13
Carolin S Hoefig, Riccardo Zucchi, Josef Koehrle
Thyronamines (3-T1AM, T0AM) are endogenous compounds probably derived from T4 or its intermediate metabolites. Combined activities of intestinal deiodinases and ornithine decarboxylase generate 3-T1AM in vitro. Alternatively, 3-T1AM might be formed by the thyroid gland and secreted into the blood. 3-T1AM and T0AM concentrations have been determined by liquid chromatography-tandem mass spectrometry analysis (LC-MS/MS) in tissues, serum and cell lines. However, large variations of 3-T1AM concentrations in human serum were reported by LC-MS/MS compared to a monoclonal antibody-based immunoassay...
September 21, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27649501/determination-of-thyroid-hormones-in-mouse-tissues-by-isotope-dilution-microflow-liquid-chromatography-mass-spectrometry-method
#14
Meri De Angelis, Florian Giesert, Brian Finan, Christoffer Clemmensen, Timo D Müller, Daniela Vogt-Weisenhorn, Matthias H Tschöp, Karl-Werner Schramm
Thyroid hormones (THs) play a critical role in the regulation of many biological processes such as growth, metabolism and development both in humans and wildlife. In general, TH levels are measured by immunoassay (IA) methods but the specificity of the antibodies used in these assays limits selectivity. In the last decade, several analytical methods using liquid chromatography-mass spectrometry (LC-MS) and tandem mass spectrometry (LC-MS/MS) have been developed to measure THs. These new techniques proved to be more accurate than the IA analysis and they were widely used for the determination of TH level in different human and animal tissues...
October 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27648348/hypercalcemia-of-malignancy
#15
REVIEW
Steve Malangone, Christopher J Campen
A 60-year-old man initially presented with pain in the right upper quadrant in October 2010. A computed tomography (CT) scan of the abdomen pelvis completed at that time showed a mass at the junction of the body and tail of the pancreas and multiple large liver lesions. A CT-guided liver biopsy revealed low-grade neuroendocrine carcinoma. The patient was initially started on systemic treatment with sunitinib (Sutent) and octreotide. He developed intolerable side effects, including nausea and migraine. Therapy was discontinued in October 2011, when a CT scan revealed evidence of disease progression...
November 2015: Journal of the Advanced Practitioner in Oncology
https://www.readbyqxmd.com/read/27625581/serum-vitamin-b12-and-thyroid-hormone-levels-in-saudi-patients-with-multiple-sclerosis
#16
Fahd A Al-Khamis
OBJECTIVES: To determine the relationship between Vitamin B12 levels and thyroid hormones in patients with multiple sclerosis (MS). MATERIALS AND METHODS: One hundred and ten patients with MS were recruited for this study after Institutional Review Board approval. All patients signed a written informed consent form and donated a single blood sample. Plasma Vitamin B12 levels, triiodothyronine (T3), and thyroxine (T4) hormone levels were measured. Data were analyzed using the Statistical Package for Social Sciences (SPSS) software...
September 2016: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/27592856/a-high-throughput-drug-screening-assay-to-identify-compounds-that-promote-oligodendrocyte-differentiation-using-acutely-dissociated-and-purified-oligodendrocyte-precursor-cells
#17
Karen D Lariosa-Willingham, Elen S Rosler, Jay S Tung, Jason C Dugas, Tassie L Collins, Dmitri Leonoudakis
BACKGROUND: Multiple sclerosis is caused by an autoimmune response resulting in demyelination and neural degeneration. The adult central nervous system has the capacity to remyelinate axons in part through the generation of new oligodendrocytes (OLs). To identify clinical candidate compounds that may promote remyelination, we have developed a high throughput screening (HTS) assay to identify compounds that promote the differentiation of oligodendrocyte precursor cells (OPCs) into OLs...
September 5, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27590548/charged-tag-founded-in-n-1-chloroalkyl-pyridinium-quaternization-for-quantification-of-fatty-aldehydes
#18
Yanjing Cao, Qing Guan, Tuanqi Sun, Wanshu Qi, Yinlong Guo
N-(1-chloroalkyl)pyridinium quaternization was developed for the derivatization of fatty aldehydes. Differing from common pre-charged reagents, non-charged pyridine and thionyl chloride were designed to add permanently charged tag on aldehydes. Pyridine was far less competitive than charged derivatives in ionization. Thionyl chloride in excess was quenched by deionized water, converting into less residual sulfur dioxide bubbles. Thus solutions could be tested directly by mass spectrometry without further post-treatments...
September 21, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27578976/higher-minor-hemoglobin-a2-levels-in-multiple-sclerosis-patients-correlate-with-lesser-disease-severity
#19
Muhammed Emin Ozcan, Bahri Ince, Hasan Huseyin Karadeli, Asuman Gedikbasi, Talip Asil, Meric A Altinoz
OBJECTIVE: To define whether minor adult hemoglobin A2 (HbA2, α2δ2) exerts any protective activity in multiple sclerosis (MS). METHODS: HbA2 levels were measured in 146 MS patients with high performance liquid chromatography and association with MS Severity Scores (MSSS) were determined. HbA2 associations with blood count parameters were also studied using blood counts evaluated on the same day of high performance liquid chromatography sampling. Routine biochemical parameters were also determined to rule out elusively influential factors, such as anemia and thyroid disorders...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27566407/proteomic-analysis-reveals-aberrant-expression-of-calr-and-hspa5-in-thyroid-tissues-of-graves-disease
#20
Shuai Meng, Wen Zhang, Li-Juan Guan, Fatuma-Said Muhali, Jiao-Zhen Zhou, Rong-Hua Song, Jian Xu, Jin-An Zhang
OBJECTIVES: To explore the proteomic changes in thyroid tissue from GD patients and find new biomarkers for the prevention, diagnosis as well as the treatment of GD. DESIGN AND METHODS: Group1 included five thyroid specimens of GD cases and 5 normal thyroid tissue samples which were removed surgically and collected. The proteins were extracted from these thyroid tissues and then the differentially expressed protein spots were identified by MALDI-TOF-MS. The interested proteins were further validated in more specimens (group2: 11 pathological thyroid specimens and 7 normal thyroid tissue samples)...
August 24, 2016: Clinical Biochemistry
keyword
keyword
6924
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"