keyword
MENU ▼
Read by QxMD icon Read
search

Ms thyroid

keyword
https://www.readbyqxmd.com/read/29759195/simultaneous-competitive-and-sandwich-formats-multiplexed-immunoassays-based-on-icp-ms-detection
#1
Yuqing Zhang, Gongwei Sun, Yi Zhang, Biao Huang, Zhi Xing, Sichun Zhang, Xinrong Zhang
Inductively Coupled Plasma Mass Spectrometry (ICP-MS) based immunoassay method has been proposed in multiple immunoassays but has not been used in competitive and sandwich formats immunoassay simultaneously. The two immunoassays were usually conducted separately in clinical field depending on the size and the amount of binding sites of targets. We proposed an immunoassay method based on magnetic beads and ICP-MS detection that could be suitable for both small and large molecules. The functionalized magnetic beads were added to capture the immune complex after immune reaction...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29691526/black-pepper-based-beverage-induced-appetite-suppressing-effects-without-altering-postprandial-glycaemia-gut-and-thyroid-hormones-or-gastrointestinal-well-being-a-randomized-crossover-study-in-healthy-subjects
#2
Yoghatama Cindya Zanzer, Merichel Plaza, Anestis Dougkas, Charlotta Turner, Elin Östman
Pleiotropic effects of spices on health, particularly on glucose metabolism and energy regulation, deserve further clinical investigation into their efficacy. The aim of the current study was to evaluate whether consumption of a black pepper-based beverage (BPB) preload containing 20 mg gallic acid equivalent (GAE) would exert any effect on postprandial glycaemia, appetite sensations, gut hormones, thyroid function, and gastrointestinal well-being after a white wheat bread (WWB) challenge meal containing 50 g available carbohydrates (CHO) compared to a control beverage...
April 25, 2018: Food & Function
https://www.readbyqxmd.com/read/29684447/type-3-iodothyronine-deiodinase-is-expressed-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#3
Kumiko Nishimura, Masafumi Takeda, Jun K Yamashita, Ichiro Shiojima, Nagaoki Toyoda
AIMS: Type 3 iodothyronine deiodinase (D3), which converts thyroxine (T4 ) and 3,5,3'-triiodothyronine (T3 ) to 3,3',5'-triiodothyronine (rT3 ) and 3,3'-diiodothyronine (T2 ), respectively, inactivates thyroid hormones. We investigated the expression and regulation of D3 in human cardiomyocytes which were differentiated from human induced pluripotent stem cells (hiPSCs). MAIN METHODS: We characterized D3 activity using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis...
April 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29666985/induction-of-disease-remission-with-one-cycle-of-alemtuzumab-in-relapsing-remitting-ms
#4
Alexandra S Kocsik, David E Klein, Maryana Liedke, Ulrike W Kaunzner, Nancy M Nealon, Susan A Gauthier, Timothy Vartanian, Jai S Perumal
OBJECTIVE: To investigate a single-course treatment with alemtuzumab in patients with relapsing-remitting multiple sclerosis. METHODS: We performed a retrospective chart review of all patients diagnosed with RRMS who were treated with alemtuzumab at our MS center and who had at least 12 month follow-up since the first dose. Data on radiological and clinical relapse were collected for the 2 years prior to patients' first dose of alemtuzumab and were tracked until the time of analysis...
April 17, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29663848/evaluation-of-the-association-between-sexual-dysfunction-and-demyelinating-plaque-location-and-number-in-female-multiple-sclerosis-patients
#5
Volkan Solmaz, Hatice Kose Ozlece, Aydın Him, Ayfer Güneş, Christian Cordano, Durdane Aksoy, Yahya Çelik
Purpose To investigate the frequency of sexual dysfunction (SD) in female multiple sclerosis (MS) patients and to explore its association with the location and number of demyelinating lesions. Material and Methods We evaluated 42 female patients and 41 healthy subjects. All patients underwent neurological examination and 1.5 T brain and full spinal MRI. All subjects completed the female sexual function index (FSFI), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Short-Form 36 Quality of Life Scale (SF-36)...
April 17, 2018: Neurological Research
https://www.readbyqxmd.com/read/29627605/evaluation-of-bisphenol-a-influence-on-endocannabinoid-system-in-pregnant-women
#6
Monika Zbucka-Kretowska, Robert Zbucki, Ewa Parfieniuk, Maciej Maslyk, Urszula Lazarek, Wojciech Miltyk, Jan Czerniecki, Slawomir Wolczynski, Adam Kretowski, Michal Ciborowski
Bisphenol A (BPA) is a synthetic chemical widely used in the industry, which may potentially evoke negative effects on human health, especially on reproductive processes and fetal development. BPA has been reported to act on estrogen, estrogen-related, androgen, thyroid hormone, pregnane X, peroxisome proliferation-activated, and aryl hydrocarbon receptors. However, other potential mechanisms of BPA action on pregnancy cannot be excluded. Comprehensive evaluation of BPA effect on pregnant women can be performed by use of metabolomics...
March 30, 2018: Chemosphere
https://www.readbyqxmd.com/read/29600441/efficacy-and-safety-of-the-newer-multiple-sclerosis-drugs-approved-since-2010
#7
REVIEW
Simon Faissner, Ralf Gold
Multiple sclerosis treatment faces tremendous changes as a result of the approval of new medications. The new medications have differing safety considerations and risks after long-term treatment, which are important for treating physicians to optimize and individualize multiple sclerosis care. Since the approval of the first multiple sclerosis capsule, fingolimod, the armamentarium of multiple sclerosis therapy has grown with the orally available medications dimethyl fumarate and teriflunomide. Fingolimod is mainly associated with cardiac side effects, dimethyl fumarate with bowel symptoms...
March 2018: CNS Drugs
https://www.readbyqxmd.com/read/29581064/molecular-signatures-of-medullary-thyroid-carcinoma-by-matrix-assisted-laser-desorption-ionisation-mass-spectrometry-imaging
#8
Andrew Smith, Manuel Galli, Isabella Piga, Vanna Denti, Martina Stella, Clizia Chinello, Nicola Fusco, Davide Leni, Marco Manzoni, Gaia Roversi, Mattia Garancini, Angela Ida Pincelli, Vincenzo Cimino, Giulia Capitoli, Fulvio Magni, Fabio Pagni
The main aim of the study was to assess the feasibility of matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) in the pathological investigation of Medullary Thyroid Carcinoma (MTC). Formalin-fixed paraffin-embedded (FFPE) samples from seven MTC patients were analysed by MALDI-MSI in order to detect proteomic alterations within tumour lesions and to define the molecular profiles of specific findings, such as amyloid deposition and C cell hyperplasia (CCH). nLC-ESI MS/MS was employed for the identification of amyloid components and to select alternative proteomic markers of MTC pathogenesis...
March 24, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29552294/integrated-analysis-of-fine-needle-aspiration-cystic-fluid-proteome-cancer-cell-secretome-and-public-transcriptome-datasets-for-papillary-thyroid-cancer-biomarker-discovery
#9
Chia-Chun Wu, Jen-Der Lin, Jeng-Ting Chen, Chih-Min Chang, Hsiao-Fen Weng, Chuen Hsueh, Hui-Ping Chien, Jau-Song Yu
Thyroid ultrasound and ultrasound-guided fine-needle aspiration (USG/FNA) biopsy are currently used for diagnosing papillary thyroid carcinoma (PTC), but their detection limit could be improved by combining other biomarkers. To discover novel PTC biomarkers, we herein applied a GeLC-MS/MS strategy to analyze the proteome profiles of serum-abundant-protein-depleted FNA cystic fluid from benign and PTC patients, as well as two PTC cell line secretomes. From them, we identified 346, 488, and 2105 proteins, respectively...
February 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29549708/detection-and-identification-of-serum-peptides-biomarker-in-papillary-thyroid-cancer
#10
Zhao-Lian Lu, Ying-Jian Chen, Xin-Yan Jing, Na-Na Wang, Ting Zhang, Cheng-Jin Hu
BACKGROUND Papillary thyroid cancer (PTC) is currently the most commonly diagnosed endocrine malignancy. In addition, the sex- and age-adjusted incidence of PTC has exhibited a greater increase over the last 2 decades than in many other malignancies. Thus, discovering noninvasive specific serum biomarker to distinguish PTC from cancer-free controls in its early stages remains an important goal. MATERIAL AND METHODS Serum samples from 88 PTC patients and 80 cancer-free controls were randomly allocated into training or validation sets...
March 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29546054/serum-trace-elements-profile-in-graves-disease-patients-with-or-without-orbitopathy-in-northeast-china
#11
Yongping Liu, Shanshan Liu, Jinyuan Mao, Sichen Piao, Jing Qin, Shiqiao Peng, Xiaochen Xie, Haixia Guan, Yushu Li, Zhongyan Shan, Weiping Teng
Objective: The purpose of the present study was to investigate serum trace elements in Graves' disease (GD) patients with or without orbitopathy in Northeast China. Methods: Patients with newly diagnosed Graves' disease (HyGD) ( n = 66), GD patients with euthyroid status or subclinical thyroidism after treatment (EUGD) ( n = 55), GO patients with euthyroid status or subclinical thyroidism after treatment (GO) ( n = 57), and normal controls (NC) ( n = 66) were enrolled in this study...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29541433/effects-of-levothyroxine-on-visual-evoked-potential-impairment-following-local-injections-of-lysolecithin-into-the-rat-optic-chiasm
#12
Cobra Payghani, Fatemeh Khani, Aryan Rafieezadeh, Parham Reisi, Hojjatallah Alaei, Bahman Rashidi
Background: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system which has no any known definitive treatment. Studies have shown that thyroid hormones (THs) in addition to their roles in the development of the nervous system and the production of myelin have important roles in the adult's brain function. Since the only way to treat MS is the restoration of myelin, the aim of this study was to evaluate the effects of levothyroxine on visual evoked potential (VEP) impairment following local injections of lysolecithin into the rat optic chiasm...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29532905/twenty-year-experience-of-paediatric-thyroid-surgery-using-intraoperative-nerve-monitoring
#13
R Schneider, A Machens, C Sekulla, K Lorenz, F Weber, H Dralle
BACKGROUND: There are few data on intermittent and continuous intraoperative nerve monitoring (IONM) during thyroidectomy in children. METHODS: All children aged 18 years or younger who had standard thyroid operations using intermittent or continuous IONM between January 1998 and December 2016 were included in the study. The impact of age and type of IONM on basal amplitude, latency and complications after thyroidectomy were assessed. RESULTS: A total of 504 children were included in the study...
March 13, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29527211/the-footprints-of-poly-autoimmunity-evidence-for-common-biological-factors-involved-in-multiple-sclerosis-and-hashimoto-s-thyroiditis
#14
Simona Perga, Serena Martire, Francesca Montarolo, Ilaria Giordani, Michela Spadaro, Gabriele Bono, Stefania Corvisieri, Ilaria Messuti, Giancarlo Panzica, Fabio Orlandi, Antonio Bertolotto
Autoimmune diseases are a diverse group of chronic disorders and affect a multitude of organs and systems. However, the existence of common pathophysiological mechanisms is hypothesized and reports of shared risk are emerging as well. In this regard, patients with multiple sclerosis (MS) have been shown to have an increased susceptibility to develop chronic autoimmune thyroid diseases, in particular Hashimoto's thyroiditis (HT), suggesting an autoimmune predisposition. However, studies comparing such different pathologies of autoimmune origin are still missing till date...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29525836/monitoring-and-management-of-autoimmunity-in-multiple-sclerosis-patients-treated-with-alemtuzumab-practical-recommendations
#15
REVIEW
Virginia Devonshire, Richard Phillips, Hilary Wass, Gerald Da Roza, Peter Senior
Alemtuzumab is a humanized anti-CD52 monoclonal antibody approved in more than 65 countries for the treatment of relapsing-remitting multiple sclerosis (RRMS). Compared with subcutaneous interferon-beta-1a, alemtuzumab significantly reduced clinical disease activity and the rate of brain volume loss, and improved disability outcomes in patients with active RRMS who were either treatment naive (CARE-MS I study) or who had an inadequate response (≥ 1 relapse after ≥ 6 months of treatment) to prior therapy (CARE-MS II study)...
March 10, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29508133/autoimmune-comorbidities-in-multiple-sclerosis-what-is-the-influence-on-brain-volumes-a-case-control-mri-study
#16
Lorena Lorefice, Giuseppe Fenu, Roberta Pitzalis, Giulia Scalas, Jessica Frau, Giancarlo Coghe, Luigina Musu, Vincenzo Sechi, Maria Antonietta Barracciu, Maria Giovanna Marrosu, Eleonora Cocco
BACKGROUND: Several studies indicated that multiple sclerosis (MS) is frequently associated with other autoimmune diseases. However, it is little known if the coexistence of these conditions may influence the radiologic features of MS, and in particular the brain volumes. OBJECTIVES: To evaluate the effect of autoimmune comorbidities on brain atrophy in a large case-control MS population. METHODS: A group of MS patients affected by a second autoimmune disorder, and a control MS group without any comorbidity, were recruited...
May 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29500905/a-sensitive-lc-ms-ms-method-for-simultaneous-determination-of-cabozantinib-and-its-metabolite-cabozantinib-n-oxide-in-rat-plasma-and-its-application-in-a-pharmacokinetic-study
#17
Lian-Jie Ren, Hua-Jing Wu, Li-Han Sun, Xue Xu, Li-Ying Mo, Lei Zhang, Jun-Ying Zhang, Chun-Yong Wu
Cabozantinib (CBZ) is used for the treatment of progressive, metastatic medullary thyroid cancer. Its major oxidative metabolite is cabozantinib N-oxide (CBN), which contains a structural alert associated with mutagenicity, yet the pharmacokinetics studies lack the simultaneous investigation of CBN and dose proportionality. In the current study a simple LC-MS/MS method was developed and validated for the simultaneous estimation and pharmacokinetic investigation of CBZ and CBN in rat plasma. The analytes were separated on a Waters Atlantics C18 column (2...
March 3, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29495350/the-role-of-insulin-resistance-hyperinsulinism-on-the-rising-trend-of-thyroid-and-adrenal-nodular-disease-in-the-current-environment
#18
REVIEW
Agathocles Tsatsoulis
Thyroid follicular cells, as well as adrenocortical cells, are endowed by an intrinsic heterogeneity regarding their growth potential, in response to various stimuli. This heterogeneity appears to constitute the underlying cause for the focal cell hyperplasia and eventually the formation of thyroid and adrenal nodules, under the influence of growth stimulatory factors. Among the main stimulatory factors are the pituitary tropic hormones, thyroid-stimulating hormone (TSH) or thyrotropin and adrenocorticotropic hormone (ACTH), which regulate the growth and function of their respective target cells, and the insulin/insulin-like growth factor system, that, through its mitogenic effects, can stimulate the proliferation of these cells...
February 26, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29492952/discrimination-of-papillary-thyroid-cancer-from-non-cancerous-thyroid-tissue-based-on-lipid-profiling-by-mass-spectrometry-imaging
#19
Anna Wojakowska, Laura M Cole, Mykola Chekan, Katarzyna Bednarczyk, Magdalena Maksymiak, Małgorzata Oczko-Wojciechowska, Barbara Jarząb, Malcolm R Clench, Joanna Polańska, Monika Pietrowska, Piotr Widlak
INTRODUCTION: The distinction of papillary thyroid carcinomas from benign thyroid lesions has important implication for clinical man-agement. Classification based on histopathological features can be supported by molecular biomarkers, including lipidomic signatures, identified with the use of high-throughput mass spectrometry techniques. Formalin fixation is a standard procedure for stabilization and preservation of tissue samples, therefore this type of samples constitute highly valuable source of clinical material for retrospective molecular studies...
2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29491723/comorbidity-in-us-patients-with-multiple-sclerosis
#20
Natalie C Edwards, Michael Munsell, Joseph Menzin, Amy L Phillips
Objective: To assess the trends in the prevalence of comorbidities in US patients with multiple sclerosis (MS), and the association of demographic characteristics with the presence of comorbidities. Study design: A retrospective analysis was conducted from a sample of 5 million patients from the IMS Health Real World Data Adjudicated Claims - US database. Methods: Comorbidity in patients with MS was assessed by year (2006-2014), and logistic regression models evaluated the association of age, sex, and region with select comorbidities...
2018: Patient related Outcome Measures
keyword
keyword
6924
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"