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https://www.readbyqxmd.com/read/29247380/utilizing-mass-spectrometry-imaging-to-map-the-thyroid-hormones-triiodothyronine-and-thyroxine-in-xenopus-tropicalis-tadpoles
#1
Naoko Goto-Inoue, Tomohiko Sato, Mizuki Morisasa, Akihiko Kashiwagi, Keiko Kashiwagi, Yuki Sugiura, Eiji Sugiyama, Makoto Suematsu, Tsukasa Mori
Thyroid hormones are not only responsible for thermogenesis and energy metabolism in animals, but also have an important role in cell differentiation and development. Amphibian metamorphosis provides an excellent model for studying the remodeling of the body. This metamorphic organ remodeling is induced by thyroid hormones, and a larval body is thus converted into an adult one. The matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry (MS) imaging technology is expected to be a suitable tool for investigating small bioreactive molecules...
December 15, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29221487/clinical-laboratory-verification-of-thyroglobulin-concentrations-in-the-presence-of-autoantibodies-to-thyroglobulin-comparison-of-eia-radioimmunoassay-and-lc-ms-ms-measurements-in-an-urban-hospital
#2
Sarah E Wheeler, Li Liu, Harry C Blair, Richard Sivak, Nancy Longo, Jeffery Tischler, Kathryn Mulvey, Octavia M Peck Palmer
OBJECTIVE: Thyroglobulin (Tg) measurements assess recurrence in post-thyroidectomy thyroid cancer patients. Tg measurements by enzyme immunoassays (EIA) can be falsely elevated by interference from Tg autoantibodies (TgAb). Radioimmunoassay (RIA) is less susceptible to TgAb interference and has been the standard-of-care test for TgAb positive patients. Recently developed liquid chromatography tandem mass spectrometry (LC-MS/MS) methods may eliminate TgAb interference. We assessed the performance of Tg measurements by EIA, RIA and LC-MS/MS to evaluate TgAb interference differences...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29198444/endocrine-and-metabolic-assessment-in-adults-with-langerhans-cell-histiocytosis
#3
L Montefusco, S Harari, D Elia, A Rossi, C Specchia, O Torre, G Adda, M Arosio
CONTEXT: Diabetes insipidus (DI) is one of most common complications of Langerhans cell histiocytosis (LCH) but prevalence of anterior pituitary deficiencies and metabolic alterations have not been clearly defined yet. OBJECTIVES: Evaluate prevalence of endocrine and metabolic manifestations in a cohort of patients affected by Pulmonary LCH. METHODS: Observational cross-sectional study on 18 adults (7 M/11 F, 42±12years) studied for complete basal and dynamic endocrine lab tests and glucose metabolism...
November 29, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29189966/management-of-adverse-renal-events-related-to-alemtuzumab-treatment-in-multiple-sclerosis-a-belgian-consensus
#4
Ben Sprangers, D Decoo, D Dive, A Lysandropoulos, L Vanopdenbosch, C Bovy
Alemtuzumab is a humanized monoclonal antibody indicated for the treatment of adult patients with relapsing-remitting multiple sclerosis with active disease. Multiple sclerosis (MS) patients treated with alemtuzumab are at increased risk for autoimmune adverse events (thyroid disorders, immune thrombocytopenia, and renal disease). The use of alemtuzumab has been associated with the development of renal immune-mediated adverse events in 0.3% of patients in clinical trials in MS, which generally occurred within 39 months of the last administration...
November 30, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29183805/proteome-profiles-of-different-types-of-thyroid-cancers
#5
Marta Gawin, Anna Wojakowska, Monika Pietrowska, Łukasz Marczak, Mykola Chekan, Karol Jelonek, Dariusz Lange, Roman Jaksik, Aleksandra Gruca, Piotr Widłak
Proteomics profiling of tissue specimens representative for major types of thyroid cancers: papillary (classical and follicular variant), follicular, anaplastic and medullary, as well as benign follicular adenoma, was performed using shotgun LC-MS/MS approaches. A combination of Orbitrap and MALDI-TOF approach allowed to identify protein products of 3700 unique genes and revealed large differences between medullary, anaplastic and epithelium-derived differentiated cancers (papillary and follicular). Proteins characteristic for medullary and anaplastic cancers included factors associated with neuroendocrine functions and factors typically associated with advanced malignancies, respectively...
November 25, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29166180/measurement-of-orbital-biomechanical-properties-in-patients-with-thyroid-orbitopathy-using-the-dynamic-scheimpflug-analyzer-corvis-st
#6
Anna Leszczynska, Karolin Moehler, Eberhard Spoerl, Lisa Ramm, Robert Herber, Lutz E Pillunat, Naim Terai
PURPOSE: To investigate orbital biomechanical properties in patients with thyroid orbitopathy and in age- and gender-matched healthy subjects using the Corvis-ST (CST, Oculus Wetzlar, Germany). METHODS: The CST allows a non-contact tonometry with an ultra-high-speed Scheimpflug device to record the deformation of the cornea during an air pulse. Biomechanical response parameters (intraocular pressure (IOP), whole eye movement length (WEMl) and time (WEMt), deflection amplitude 2 mm ratio max, deflection amplitude max, stiffness parameter, and biomechanically corrected IOP were measured in 39 patients with thyroid orbitopathy (= group I) and in 33 age- and gender-matched healthy subjects (= group II) using the CST...
November 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29162998/symptomatic-first-degree-atrioventricular-block-in-a-young-woman-after-taking-a-fat-burner-supplement
#7
Renda E M Abdelmageed, H B Xiao
A 22-year-old woman collapsed at home and was brought to the accident and emergency department. History revealed that she was fit and taken T5 capsule the night before the collapse. There was no history of similar collapses or seizure. Examination revealed blood pressure (BP) of 104/69 mmHg and a heart rate (HR) of 70 bpm. Chest, cardiovascular, and neurology examination were unremarkable. However, on standing, her HR increased to 120 bpm, and her BP dropped to 62/40 mmHg. Blood Na, K, Ca, Mg, phosphate, creatinine, complete blood count, T4 cortisol, and thyroid-stimulating hormone (TSH) were normal...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29083134/clinical-endocrinology-and-hormones-quantitation-the-increasing-role-of-mass-spectrometry
#8
Federica D'Aurizio, Marco Cantù
Clinical endocrinology has always had a close relationship with laboratory medicine. In fact, the quantification of hormones is of great importance for diagnosis, treatment, recurrence and patient's prognosis of endocrine disorders. This review dealt with the role of the laboratory in diagnosing endocrine pathologies related to adrenal gland, pituitary, gonads and thyroid. The measurements of the main hormones (17- hydroxyprogesterone, androstenedione, dehydroepiandrosterone sulphate, testosterone, estradiol, cortisol, aldosterone, metanephrines, thyroglobulin and insulin-like-growth factor-1) were described considering analytical characteristics but also some aspects of pre-analytical and post- analytical steps...
October 27, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29080770/atypical-fatal-sarcocystosis-associated-with-sarcocystis-neurona-in-a-white-nosed-coati-nasua-narica-molaris
#9
Jitender P Dubey, John G Trupkiewicz, Shiv K Verma, Joseph D Mowery, Gloria Adedoyin, Tim Georoff, Michael E Grigg
The protozoan parasite Sarcocystis neurona is an important cause of disease in horses (equine protozoal myeloencephalitis, EPM) and marine mammals. Isolated reports of clinical EPM-like disease have been documented in a zebra, raccoon, domestic cat, domestic dog, ferret, skunk, mink, lynx, red panda and fisher. The predominant disease is encephalomyelitis associated with schizonts in neural tissues. Here, we report highly disseminated sarcocystosis, in many tissues of a captive White-nosed coati (Nasua narica molaris)...
November 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/29071976/-hypothalamic-transcription-profiles-associated-with-twirling-reducing-needling-in-rats-with-stress-induced-prehypertension
#10
Qi-Sheng Sun, Qi-Ying Guo, Wen-Rui Jia, Zong-Yu Jin, Zhi Ji, Qiu-Lei Guo, Fang-Yuan Yang, He Zhan, He Wang, Qing-Guo Liu
OBJECTIVE: To observe the effect of twirling-reducing needling on changes of profile of differentially-expressed genes in the hypothalamus in rats with stress-induced prehypertension (SI-PHT), so as to explore its mechanism under-lying improvement of prehypertension. METHODS: Wistar male rats were randomly divided into blank control group (n=12), model group (n=12) and acupuncture group (n=10). The SI-PHT model was established by planta-electric-shock stimulation (30 V, 5 s) plus noise stimulation (80-100 db, 50 ms), twice daily, continuously for 11 days...
June 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29040951/perfluoroalkyl-substances-bone-density-and-cardio-metabolic-risk-factors-in-obese-8-12-year-old-children-a-pilot-study
#11
Naila Khalil, James R Ebert, Masato Honda, Miryoung Lee, Ramzi W Nahhas, Antti Koskela, Thomas Hangartner, Kurunthachalam Kannan
BACKGROUND AND OBJECTIVE: Perfluoroalkyl substances (PFASs), including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), have been associated with adverse bone, and metabolic changes in adults. However association of PFASs with bone health in children is understudied. Considering their role as endocrine disruptors, we examined relationships of four PFASs with bone health in children. METHODS: In a cross sectional pilot study, 48 obese children aged 8-12 years were enrolled from Dayton's Children Hospital, Ohio...
October 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/29033895/autoimmune-thyroid-diseases-in-patients-treated-with-alemtuzumab-for-multiple-sclerosis-an-example-of-selective-anti-tsh-receptor-immune-response
#12
REVIEW
Mario Rotondi, Martina Molteni, Paola Leporati, Valentina Capelli, Michele Marinò, Luca Chiovato
Alemtuzumab, a humanized anti-CD52 monoclonal antibody, is approved for the treatment of active relapsing-remitting multiple sclerosis (MS). Alemtuzumab induces a rapid and prolonged depletion of lymphocytes from the circulation, which results in a profound immuno-suppression status followed by an immune reconstitution phase. Secondary to reconstitution autoimmune diseases represent the most common side effect of Alemtuzumab treatment. Among them, Graves' disease (GD) is the most frequent one with an estimated prevalence ranging from 16...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29028670/cord-blood-bisphenol-a-levels-and-reproductive-and-thyroid-hormone-levels-of-neonates-the-hokkaido-study-on-environment-and-children-s-health
#13
Machiko Minatoya, Seiko Sasaki, Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Jun Yamamoto, Toru Matsumura, Takahiko Mitsui, Kimihiko Moriya, Kazutoshi Cho, Keita Morioka, Hisanori Minakami, Nobuo Shinohara, Reiko Kishi
BACKGROUND: Bisphenol A (BPA) is widely used and BPA exposure is nearly ubiquitous in developed countries. While animal studies have indicated adverse health effects of prenatal BPA exposure including reproductive dysfunction and thyroid function disruption possibly in a sex-specific manner, findings from epidemiologic studies have not been enough to prove these adverse effects. Given very limited research on human, the aim of this study was to investigate associations between cord blood BPA levels and reproductive and thyroid hormone levels of neonates and whether associations differed by neonate sex...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/28989911/the-effect-of-levothyroxine-on-serum-levels-of-interleukin-10-and-interferon-gamma-in-rat-model-of-multiple-sclerosis
#14
Cobra Payghani, Fatemeh Khani, Aryan Rafiee Zadeh, Parham Reisi, Hojjatallah Alaei, Bahman Rashidi
BACKGROUND: There is an increase in inflammatory and a reduction in anti-inflammatory cytokines in multiple sclerosis (MS). Considering the role of thyroid hormones in the development and regulation of both neural and immune systems, the aim of this study was to evaluate the effects of levothyroxine on serum concentrations of interleukin-10 (IL-10) and interferon gamma (IFN-γ) in animal models of MS. MATERIALS AND METHODS: To induce demyelination in male Wistar rats, lysolecithin was injected into the optic chiasm...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28958220/collective-ion-pair-single-drop-microextraction-attenuated-total-reflectance-fourier-transform-infrared-spectroscopic-determination-of-perchlorate-in-bioenvironmental-samples
#15
Swati Chandrawanshi, Santosh K Verma, Manas K Deb
Perchlorate (ClO₄(−)) is an environmental pollutant thataffects human health. Perchlorate acts as a competitive inhibitor of iodine uptake in the thyroid gland (sodium–iodide symporter inhibitor); thus, its determination is important for public health concerns. Water and milk constitute a significant portion of the human diet. Because regular intake leads to an increase in perchlorate concentration in the human body, the estimation of perchlorate is of great concern. In this work, ion-pair single-drop microextraction (SDME) combined with attenuated total reflectance (ATR)-FTIR spectroscopy has been developed for the determination of perchlorate in bioenvironmental (soil, water, dairy milk, breast milk, and urine) samples...
September 28, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28927140/itraq-coupled-2d-lc-ms-ms-analysis-of-cxcr7-transfected-papillary-thyroid-carcinoma-cells-a-new-insight-into-cxcr7-regulation-of-papillary-thyroid-carcinoma-progression-and-identification-of-potential-biomarkers
#16
Hengwei Zhang, Lei Yang, Zhangyi Liu, Chenxi Liu, Xuyong Teng, Lei Zhang, Bo Yin, Zhen Liu
Previous studies have demonstrated that C-X-C chemokine receptor type 7 (CXCR7) regulates papillary thyroid carcinoma (PTC) growth and metastasis; however, the molecular mechanisms underlying this regulation remain unclear. In the present study, the protein expression profiles of the PTC cell line GLAG-66 and GLAG-66 cells stably transfected with CXCR7 cDNA were analyzed and compared using isobaric tag for relative and absolute quantification-coupled two-dimensional liquid chromatography-tandem mass spectrometry...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28837607/a-validated-lc-ms-ms-method-for-cellular-thyroid-hormone-metabolism-uptake-and-turnover-of-mono-iodinated-thyroid-hormone-metabolites-by-pccl3-thyrocytes
#17
Keith H Richards, Nancy Schanze, Ray Monk, Eddy Rijntjes, Daniel Rathmann, Josef Köhrle
Tyrosine and phenolic ring de-iodination of thyroid hormones (TH) is crucial for regulating their physiological activity. Furthermore, reactions such as de-carboxylation to thyronamines (TAM) and de-amination to thyroacetic acids (TAc) produce TH metabolites (THM) with distinct biological properties. This needs to be considered when studying effects of TH and THM. The accurate and precise quantitative analysis of TH and THM in cell culture supernatants and cell lysates are key procedures required for studying the in vitro metabolism of TH...
2017: PloS One
https://www.readbyqxmd.com/read/28835403/alemtuzumab-care-ms-ii-5-year-follow-up-efficacy-and-safety-findings
#18
Alasdair J Coles, Jeffrey A Cohen, Edward J Fox, Gavin Giovannoni, Hans-Peter Hartung, Eva Havrdova, Sven Schippling, Krzysztof W Selmaj, Anthony Traboulsee, D Alastair S Compston, David H Margolin, Karthinathan Thangavelu, Madalina C Chirieac, Darlene Jody, Panos Xenopoulos, Richard J Hogan, Michael A Panzara, Douglas L Arnold
OBJECTIVE: To evaluate 5-year efficacy and safety of alemtuzumab in patients with active relapsing-remitting multiple sclerosis and inadequate response to prior therapy. METHODS: In the 2-year Comparison of Alemtuzumab and Rebif Efficacy in Multiple Sclerosis (CARE-MS) II study (NCT00548405), alemtuzumab-treated patients received 2 courses (baseline and 12 months later). Patients could enter an extension (NCT00930553), with as-needed alemtuzumab retreatment for relapse or MRI activity...
September 12, 2017: Neurology
https://www.readbyqxmd.com/read/28835401/alemtuzumab-care-ms-i-5-year-follow-up-durable-efficacy-in-the-absence-of-continuous-ms-therapy
#19
RANDOMIZED CONTROLLED TRIAL
Eva Havrdova, Douglas L Arnold, Jeffrey A Cohen, Hans-Peter Hartung, Edward J Fox, Gavin Giovannoni, Sven Schippling, Krzysztof W Selmaj, Anthony Traboulsee, D Alastair S Compston, David H Margolin, Karthinathan Thangavelu, Claudio E Rodriguez, Darlene Jody, Richard J Hogan, Panos Xenopoulos, Michael A Panzara, Alasdair J Coles
OBJECTIVE: To evaluate 5-year efficacy and safety of alemtuzumab in treatment-naive patients with active relapsing-remitting MS (RRMS) (CARE-MS I; NCT00530348). METHODS: Alemtuzumab-treated patients received treatment courses at baseline and 12 months later; after the core study, they could enter an extension (NCT00930553) with as-needed alemtuzumab retreatment for relapse or MRI activity. Assessments included annualized relapse rate (ARR), 6-month confirmed disability worsening (CDW; ≥1-point Expanded Disability Status Scale [EDSS] score increase [≥1...
September 12, 2017: Neurology
https://www.readbyqxmd.com/read/28776686/contralateral-r1-and-r2-components-of-the-laryngeal-adductor-reflex-in-humans-under-general-anesthesia
#20
Catherine F Sinclair, Maria J Téllez, Oscar R Tapia, Sedat Ulkatan
OBJECTIVES: To demonstrate that under total intravenous general anesthesia (TIVA), the contralateral R1 (cRI) and contralateral R2 (cR2) components of the laryngeal adductor reflex (LAR) can be reliably elicited; to determine effects of topical anesthesia and inhalational anesthesia on the LAR; and to discuss how this technique may be utilized to continuously monitor the vagus nerve reflex arc. STUDY DESIGN: Case series. METHODS: Vocal fold mucosa was electrically stimulated via endotracheal tube surface-based electrodes to elicit a LAR...
August 4, 2017: Laryngoscope
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