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https://www.readbyqxmd.com/read/28535299/analysis-of-bacterial-metagenomes-from-the-southwestern-gulf-of-mexico-for-pathogens-detection
#1
Wendy Escobedo-Hinojosa, Liliana Pardo-López
Little is known about the diversity of bacteria in the Southwestern Gulf of Mexico. The aim of the study illustrated in this perspective was to search for the presence of bacterial pathogens in this ecosystem, using metagenomic data recently generated by the Mexican research group known as the Gulf of Mexico Research Consortium. Several genera of bacteria annotated as pathogens were detected in water and sediment marine samples. As expected, native and ubiquitous pathogenic bacteria genera such as Burkolderia, Halomonas, Pseudomonas, Shewanella, and Vibrio were highly represented...
May 23, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28526066/transovarial-transmission-of-denv-in-aedes-aegypti-in-the-amazon-basin-a-local-model-of-xenomonitoring
#2
Cristiano Fernandes da Costa, Ricardo Augusto Dos Passos, José Bento Pereira Lima, Rosemary Aparecida Roque, Vanderson de Souza Sampaio, Thais Bonifácio Campolina, Nágila Francinete Costa Secundino, Paulo Filemon Paolucci Pimenta
BACKGROUND: Transovarial transmission of dengue virus in Aedes spp. mosquitoes is considered an important mechanism for the maintenance of the virus in nature and may be implicated in the occurrence of outbreaks and epidemics of the disease. However, there are few studies involving transovarial transmission and viral vector monitoring as a surveillance tool and control strategy. The present study evaluated transovarial transmission of dengue virus in Aedes aegypti populations as a xenomonitoring strategy in municipalities of the Amazonas state...
May 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28520492/use-of-a-digital-health-application-for-influenza-surveillance-in-china
#3
Yulin Hswen, John S Brownstein, Jeremiah Liu, Jared B Hawkins
OBJECTIVES: To examine whether a commercial digital health application could support influenza surveillance in China. METHODS: We retrieved data from the Thermia online and mobile educational tool, which allows parents to monitor their children's fever and infectious febrile illnesses including influenza. We modeled monthly aggregated influenza-like illness case counts from Thermia users over time and compared them against influenza monthly case counts obtained from the National Health and Family Planning Commission of the People's Republic of China by using time series regression analysis...
May 18, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28516864/genomic-analysis-of-salmonella-enterica-serovar-typhimurium-dt160-associated-with-a-14-year-outbreak-new-zealand-1998-2012
#4
Samuel J Bloomfield, Jackie Benschop, Patrick J Biggs, Jonathan C Marshall, David T S Hayman, Philip E Carter, Anne C Midwinter, Alison E Mather, Nigel P French
During 1998-2012, an extended outbreak of Salmonella enterica serovar Typhimurium definitive type 160 (DT160) affected >3,000 humans and killed wild birds in New Zealand. However, the relationship between DT160 within these 2 host groups and the origin of the outbreak are unknown. Whole-genome sequencing was used to compare 109 Salmonella Typhimurium DT160 isolates from sources throughout New Zealand. We provide evidence that DT160 was introduced into New Zealand around 1997 and rapidly propagated throughout the country, becoming more genetically diverse over time...
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28514636/eco-evolutionary-theory-and-insect-outbreaks
#5
David J Páez, Vanja Dukic, Jonathan Dushoff, Arietta Fleming-Davies, Greg Dwyer
Eco-evolutionary theory argues that population cycles in consumer-resource interactions are partly driven by natural selection, such that changes in densities and changes in trait values are mutually reinforcing. Evidence that the theory explains cycles in nature, however, is almost nonexistent. Experimental tests of model assumptions are logistically impractical for most organisms, while for others, evidence that population cycles occur in nature is lacking. For insect baculoviruses in contrast, tests of model assumptions are straightforward, and there is strong evidence that baculoviruses help drive population cycles in many insects, including the gypsy moth that we study here...
June 2017: American Naturalist
https://www.readbyqxmd.com/read/28512705/predicting-fecal-coliform-using-the-interval-to-interval-approach-and-swat-in-the-miyun-watershed-china
#6
Jianwen Bai, Zhenyao Shen, Tiezhu Yan, Jiali Qiu, Yangyang Li
Pathogens in manure can cause waterborne-disease outbreaks, serious illness, and even death in humans. Therefore, information about the transformation and transport of bacteria is crucial for determining their source. In this study, the Soil and Water Assessment Tool (SWAT) was applied to simulate fecal coliform bacteria load in the Miyun Reservoir watershed, China. The data for the fecal coliform were obtained at three sampling sites, Chenying (CY), Gubeikou (GBK), and Xiahui (XH). The calibration processes of the fecal coliform were conducted using the CY and GBK sites, and validation was conducted at the XH site...
May 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28512093/population-genomic-analysis-of-1-777-extended-spectrum-beta-lactamase-producing-klebsiella-pneumoniae-isolates-houston-texas-unexpected-abundance-of-clonal-group-307
#7
S Wesley Long, Randall J Olsen, Todd N Eagar, Stephen B Beres, Picheng Zhao, James J Davis, Thomas Brettin, Fangfang Xia, James M Musser
Klebsiella pneumoniae is a major human pathogen responsible for high morbidity and mortality rates. The emergence and spread of strains resistant to multiple antimicrobial agents and documented large nosocomial outbreaks are especially concerning. To develop new therapeutic strategies for K. pneumoniae, it is imperative to understand the population genomic structure of strains causing human infections. To address this knowledge gap, we sequenced the genomes of 1,777 extended-spectrum beta-lactamase-producing K...
May 16, 2017: MBio
https://www.readbyqxmd.com/read/28506278/a-framework-for-evaluating-epidemic-forecasts
#8
Farzaneh Sadat Tabataba, Prithwish Chakraborty, Naren Ramakrishnan, Srinivasan Venkatramanan, Jiangzhuo Chen, Bryan Lewis, Madhav Marathe
BACKGROUND: Over the past few decades, numerous forecasting methods have been proposed in the field of epidemic forecasting. Such methods can be classified into different categories such as deterministic vs. probabilistic, comparative methods vs. generative methods, and so on. In some of the more popular comparative methods, researchers compare observed epidemiological data from the early stages of an outbreak with the output of proposed models to forecast the future trend and prevalence of the pandemic...
May 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28506274/contextual-and-psychosocial-factors-predicting-ebola-prevention-behaviours-using-the-ranas-approach-to-behaviour-change-in-guinea-bissau
#9
Anna E Gamma, Jurgita Slekiene, Gregor von Medeazza, Fredrik Asplund, Placido Cardoso, Hans-Joachim Mosler
BACKGROUND: The outbreak of the Ebola virus disease (EVD) in West Africa in December 2013 was the largest Ebola outbreak in history. This study aimed to measure the underlying contextual and psychosocial factors of intentions to perform Ebola prevention behaviours (not touching people who might be suffering from Ebola, reporting suspected cases to the National Ebola Hotline, NEH) in Guinea-Bissau. Geographical location, cross-border market activities, poor water, sanitation and hygiene (WASH) conditions, and burial practices in some communities pose a serious risk in terms of potential EVD outbreak and seriously hamper its prevention in Guinea-Bissau...
May 15, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28500789/atlantic-small-mammal-a-dataset-of-communities-of-rodents-and-marsupials-of-the-atlantic-forests-of-south-america
#10
Ricardo S Bovendorp, Nacho Villar, Edson F de Abreu-Junior, Carolina Bello, André L Regolin, Alexandre R Percequillo, Mauro Galetti
The contribution of small mammal ecology to the understanding of macroecological patterns of biodiversity, population dynamics and community assembly has been hindered by the absence of large datasets of small mammal communities from tropical regions. Here we compile the largest dataset of inventories of small mammal communities for the Neotropical region. The dataset reviews small mammal communities from the Atlantic forest of South America, one of the regions with the highest diversity of small mammals and a global biodiversity hotspot, though currently covering less than 12% of its original area due to anthropogenic pressures...
May 13, 2017: Ecology
https://www.readbyqxmd.com/read/28491893/predictors-of-dengue-related-mortality-and-disease-severity-in-a-tertiary-care-center-in-north-india
#11
Siddharth Jain, Abhenil Mittal, Surendra Kumar Sharma, Ashish Datt Upadhyay, Ravindra Mohan Pandey, Sanjeev Sinha, Manish Soneja, Ashutosh Biswas, Ranveer Singh Jadon, Mahadeo B Kakade, Cecilia Dayaraj
BACKGROUND: There is lack of reliable predictors of disease severity and mortality in dengue. The present study was carried out to identify these predictors during the 2015 outbreak in India. METHODS: This prospective observational study included confirmed adult dengue patients hospitalized between August and November 2015 in a tertiary care centre in New Delhi, India. Appropriate statistical tests were used to compare clinicolaboratory characteristics, derive predictors of severe disease and mortality, and compute a predictive score for mortality...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28487212/mapping-the-ecoepidemiology-of-zika-virus-infection-in-urban-and-rural-areas-of-pereira-risaralda-colombia-2015-2016-implications-for-public-health-and-travel-medicine
#12
Alfonso J Rodriguez-Morales, Pablo Ruiz, Javier Tabares, Carlos Augusto Ossa, Maria Camila Yepes-Echeverry, Valeria Ramirez-Jaramillo, Maria Leonor Galindo-Marquez, Carlos Julian García-Loaiza, Juan Alejandro Sabogal-Roman, Esteban Parra-Valencia, Guillermo J Lagos-Grisales, Carlos O Lozada-Riascos, Cornelis A de Pijper, Martin P Grobusch
OBJECTIVE: Geographical information systems (GIS) have been demonstrated earlier to be of great use to inform public health action against vector-borne infectious diseases. METHODS: Using surveillance data on the ongoing ZIKV outbreak from Pereira, Colombia (2015-2016), we estimated incidence rates (cases/100,000 population), and developed maps correlating with the ecoepidemiology of the area. RESULTS: Up to October 8, 2016, 439 cases of ZIKV were reported in Pereira (93 cases/100,000 pop...
May 6, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28487177/predicted-vs-observed-effectiveness-of-outer-membrane-vesicle-omv-vaccines-against-meningococcal-serogroup-b-disease-systematic-review
#13
Thomas Harder, Judith Koch, Ole Wichmann, Wiebke Hellenbrand
IMPORTANCE: Human serum bactericidal antibody levels (hSBA) are commonly used as an immune correlate of protection after vaccination against meningococcal disease. We performed a systematic review of how well this marker correlates with protection induced by outer membrane vesicle (OMV) vaccines against meningococcal B (MenB) disease. OBJECTIVE: To compare vaccine effectiveness (VE) of OMV vaccines against MenB predicted by hSBA (predicted protection) to VE from clinical studies (observed protection)...
May 6, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28468851/whole-genome-sequencing-reveals-the-contribution-of-long-term-carriers-in-staphylococcus-aureus-outbreak-investigation
#14
N C Gordon, B Pichon, T Golubchik, D J Wilson, J Paul, D S Blanc, K Cole, J Collins, N Cortes, M Cubbon, F K Gould, P J Jenks, M Llewelyn, J Q Nash, J M Orendi, K Paranthaman, J Price, L Senn, H L Thomas, S Wyllie, D W Crook, T E A Peto, A S Walker, A M Kearns
Whole genome sequencing (WGS) makes it possible to determine the relatedness of bacterial isolates at high resolution, helping to characterise outbreaks. However, for Staphylococcus aureus, accumulation of within-host diversity during carriage might limit interpretation of sequencing data.In this study, we hypothesised the converse: that within-host diversity can in fact be exploited to reveal the involvement of long-term carriers (LTCs) in outbreaks. We analysed WGS data from 20 historical outbreaks, and applied phylogenetic methods to assess genetic relatedness and estimate time to most recent common ancestor (TMRCA)...
May 3, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28465426/a-novel-agonist-of-the-trif-pathway-induces-a-cellular-state-refractory-to-replication-of-zika-chikungunya-and-dengue-viruses
#15
Kara M Pryke, Jinu Abraham, Tina M Sali, Bryan J Gall, Iris Archer, Andrew Liu, Shelly Bambina, Jason Baird, Michael Gough, Marita Chakhtoura, Elias K Haddad, Ilsa T Kirby, Aaron Nilsen, Daniel N Streblow, Alec J Hirsch, Jessica L Smith, Victor R DeFilippis
The ongoing concurrent outbreaks of Zika, Chikungunya, and dengue viruses in Latin America and the Caribbean highlight the need for development of broad-spectrum antiviral treatments. The type I interferon (IFN) system has evolved in vertebrates to generate tissue responses that actively block replication of multiple known and potentially zoonotic viruses. As such, its control and activation through pharmacological agents may represent a novel therapeutic strategy for simultaneously impairing growth of multiple virus types and rendering host populations resistant to virus spread...
May 2, 2017: MBio
https://www.readbyqxmd.com/read/28464971/a-simple-microsoft-excel-method-to-predict-antibiotic-outbreaks-and-underutilization
#16
Cristina Miglis, Nathaniel J Rhodes, Sean N Avedissian, Teresa R Zembower, Michael Postelnick, Richard G Wunderink, Sarah H Sutton, Marc H Scheetz
Benchmarking strategies are needed to promote the appropriate use of antibiotics. We have adapted a simple regressive method in Microsoft Excel that is easily implementable and creates predictive indices. This method trends consumption over time and can identify periods of over- and underuse at the hospital level.
May 3, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28464493/climate-driven-geographic-distribution-of-the-desert-locust-during-recession-periods-subspecies-niche-differentiation-and-relative-risks-under-scenarios-of-climate-change
#17
Christine N Meynard, Pierre-Emmanuel Gay, Michel Lecoq, Antoine Foucart, Cyril Piou, Marie-Pierre Chapuis
The desert locust is an agricultural pest that is able to switch from a harmless solitarious stage during recession periods, to swarms of gregarious individuals that disperse long distances and affect areas from western Africa to India during outbreak periods. Large outbreaks have been recorded through centuries, and the Food and Agriculture Organization keeps a long-term, large-scale monitoring survey database in the area. However, there is also a much less known subspecies that occupies a limited area in southern Africa...
May 2, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28462035/whole-genome-sequencing-of-group-a-streptococcus-development-and-evaluation-of-an-automated-pipeline-for-emmgene-typing
#18
Georgia Kapatai, Juliana Coelho, Steven Platt, Victoria J Chalker
Streptococcus pyogenes group A Streptococcus (GAS) is the most common cause of bacterial throat infections, and can cause mild to severe skin and soft tissue infections, including impetigo, erysipelas, necrotizing fasciitis, as well as systemic and fatal infections including septicaemia and meningitis. Estimated annual incidence for invasive group A streptococcal infection (iGAS) in industrialised countries is approximately three per 100,000 per year. Typing is currently used in England and Wales to monitor bacterial strains of S...
2017: PeerJ
https://www.readbyqxmd.com/read/28459838/ebola-management-centre-proximity-associated-with-reduced-delays-of-healthcare-of-ebola-virus-disease-evd-patients-tonkolili-sierra-leone-2014-15
#19
Georgios Theocharopoulos, Kostas Danis, Jane Greig, Alexandra Hoffmann, Henriette De Valk, Augustine Jimissa, Sumaila Tejan, Mohammed Sankoh, Karline Kleijer, Will Turner, Jay Achar, Jennifer Duncombe, Kamalini Lokuge, Ivan Gayton, Rob Broeder, Ronald Kremer, Grazia Caleo
Between August-December 2014, Ebola Virus Disease (EVD) patients from Tonkolili District were referred for care to two Médecins Sans Frontières (MSF) Ebola Management Centres (EMCs) outside the district (distant EMCs). In December 2014, MSF opened an EMC in Tonkolili District (district EMC). We examined the effect of opening a district-based EMC on time to admission and number of suspect cases dead on arrival (DOA), and identified factors associated with fatality in EVD patients, residents in Tonkolili District...
2017: PloS One
https://www.readbyqxmd.com/read/28455335/yersinia-pestis-resists-predation-by-acanthamoeba-castellanii-and-exhibits-prolonged-intracellular-survival
#20
Javier A Benavides-Montaño, Viveka Vadyvaloo
Plague is a flea-borne rodent-associated zoonotic disease caused by Yersinia pestis The disease is characterized by epizootics with high rodent mortalities, punctuated by inter-epizootic periods when the bacterium persists in an unknown reservoir. This study investigates the interaction between Y. pestis and the ubiquitous soil free-living amoeba (FLA), Acanthamoeba castellanii, to assess if the bacterium can survive within soil amoeba and whether intracellular mechanisms are conserved between infection of mammalian macrophages and soil amoeba...
April 28, 2017: Applied and Environmental Microbiology
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