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https://www.readbyqxmd.com/read/29729360/intra-operative-onabotunlinumtoxin-a-reduces-post-operative-narcotic-and-anticholinergic-requirements-after-continent-bladder-reconstruction
#1
Molly E Fuchs, Nicholas Beecroft, Daryl J McLeod, Daniel G Dajusta, Christina B Ching
OBJECTIVE: To determine if intra-detrusor injection of Onobotulinumtoxin-A (BTX-A) would reduce post-operative narcotic and anticholinergic requirements in children undergoing open continent bladder reconstruction. METHODS: After IRB approval, we retrospectively reviewed all bladder reconstructions performed. Bladder reconstruction was defined as the following procedures in any combination: bladder neck reconstruction and sling, bladder neck closure, mitrofanoff, monti or bladder augmentation We identified 15 children who underwent reconstruction with BTX-A injection and compared these to 15 children who did not receive BTX-A...
May 2, 2018: Urology
https://www.readbyqxmd.com/read/29717628/adipose-derived-stem-cell-implanted-poly-%C3%AF%C2%B5-caprolactone-chitosan-scaffold-improves-bladder-regeneration-in-a-rat-model
#2
Zhe Zhou, Hao Yan, Yidong Liu, Dongdong Xiao, Wei Li, Qiong Wang, Yang Zhao, Kang Sun, Ming Zhang, Mujun Lu
AIM: The study investigated the feasibility of seeding adipose-derived stem cells (ASCs) onto a poly(ϵ-caprolactone)/chitosan (PCL/CS) scaffold for bladder reconstruction using a rat model of bladder augmentation. MATERIALS & METHODS: In the experimental group, the autologous ASCs were seeded onto the PCL/CS scaffold for bladder augmentation. An unseeded scaffold was used for bladder augmentation as control group. The sham group was also set. RESULT: 8 weeks after implantation, more densely smooth muscles were detected in the experimental group with a larger bladder capacity and more intensive blood vessels...
April 2018: Regenerative Medicine
https://www.readbyqxmd.com/read/29710461/overexpression-of-crnde-promotes-the-progression-of-bladder-cancer
#3
Jianli Cheng, Jieqing Chen, Xintao Zhang, Hongbing Mei, Feng Wang, Zhiming Cai
Accumulating evidences indicate that long non-coding RNAs (lncRNAs) are indispensable in cancer initiation and progression. Dysregulation of functional lncRNAs can promote the development of cancers. Previous research have revealed that augmented expression of CRNDE caused poor prognosis of cancer patients and facilitate the tumor progress in various cancers. Nevertheless, the underlying roles of CRNDE in bladder cancer progression are not entirely clear. To further identify the effects CRNDE in bladder cancer progression, we performed the gain and loss of function assay...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29681270/augmented-bladders-and-urinary-diversions
#4
REVIEW
Peter Metcalfe, Shuba De, Greg Bailly
No abstract text is available yet for this article.
April 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29675856/adreno-muscarinic-synergy-in-the-male-human-urinary-outflow-tract
#5
Sebastian Walther, Frank Strittmatter, Martin Hennenberg, Christian Gratzke, Christian G Stief, Alexander Roosen
AIM: To examine putative interaction between adrenergic and muscarinic contractile activation in the human urinary outflow tract. METHODS: Tissue from the trigone and prostatic urethra was obtained from 12 cystectomy and 16 prostatectomy specimen. Contractions were elicited by exposure to exogenous agonists before and after inhibition of Rho kinase and protein kinase c (PKC). Immunofluorescence and Western-blot studies were performed using antibodies to muscarinic M3-receptors (M3-R) and alpha1A-adrenoreceptors (alpha1A-AR)...
April 20, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29664225/improvement-of-dose-calculation-in-radiation-therapy-due-to-metal-artifact-correction-using-the-augmented-likelihood-image-reconstruction
#6
Christian Ziemann, Maik Stille, Florian Cremers, Thorsten M Buzug, Dirk Rades
BACKGROUND: Metal artifacts caused by high-density implants lead to incorrectly reconstructed Hounsfield units in computed tomography images. This can result in a loss of accuracy in dose calculation in radiation therapy. This study investigates the potential of the metal artifact reduction algorithms, Augmented Likelihood Image Reconstruction and linear interpolation, in improving dose calculation in the presence of metal artifacts. MATERIALS AND METHODS: In order to simulate a pelvis with a double-sided total endoprosthesis, a polymethylmethacrylate phantom was equipped with two steel bars...
April 17, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29664178/hypothyroidism-impairs-somatovisceral-reflexes-involved-in-micturition-of-female-rabbits
#7
Octavio Sánchez-García, Rhode López-Juárez, Julia Rodríguez-Castelán, Dora L Corona-Quintanilla, Margarita Martínez-Gómez, Estela Cuevas-Romero, Francisco Castelán
AIMS: To determine the impact of hypothyroidism on the bladder and urethral functions as well as in the activation of the pubococcygeous (Pcm) and bulbospongiosus (Bsm) during micturition. METHODS: Age-matched control and methimazole-induced hypothyroid female rabbits were used to simultaneously record cystometrograms, urethral pressure, and the reflex activation of Pcm and Bsm during the induced micturition. Urodynamic and urethral variables were measured. Activation or no activation of the Pcm and Bsm during the storage and voiding phases of micturition were categorized as 1 or 0...
April 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29649545/complete-primary-repair-of-bladder-exstrophy-cpre-critical-analysis-of-the-long-term-outcome
#8
Hesham O Arab, Tamer E Helmy, Ahmed Abdelhalim, Mohamed Soltan, Mohamed E Dawaba, Ashraf T Hafez
OBJECTIVES: To demonstrate the long term outcome of a contemporary series of 64 children who underwent CPRE in a single tertiary referral center. METHODS: Between 1998 and 2012, 64 children; 47 boys and 17 girls were identified. Only 60 out of the 64 cases were available for follow up. Follow up was done by renal bladder ultrasound (RBUS) and serum creatinine every 3 months and Voiding cystourethrogram (VCUG) between 6 to 12 months post operatively. Continence was defined as dryness ≥3 hours...
April 9, 2018: Urology
https://www.readbyqxmd.com/read/29611674/augmented-reality-during-robot-assisted-radical-prostatectomy-expert-robotic-surgeons-on-the-spot-insights-after-live-surgery
#9
Francesco Porpiglia, Riccardo Bertolo, Daniele Amparore, Enrico Checcucci, Walter Artibani, Prokar Dasgupta, Francesco Montorsi, Ashutosh Tewari, Cristian Fiori
3D reconstruction of the standard two-dimension cross-sectional imaging has known increasing diffusion. It may represent one of the key points for a tailored treatment planning. Along these lines, we used a novel software for augmented-reality robot-assisted radical prostatectomy (AR-RARP) at our Institution. 3D virtual models of the prostate and the prostate cancer were reconstructed from high resolution (1-mm slices) multi-parametric Magnetic Resonance Imaging (mp-MRI) by M3dics (Turin, Italy). The innovation in the study is represented by the software-based integration of the virtual model inside the Da Vinci (Intuitive, Sunnyvale, CA, USA) robotic console during robotic prostatectomy...
April 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29555156/achieving-urinary-continence-in-cloacal-exstrophy-the-surgical-cost
#10
Mahir Maruf, Matthew Kasprenski, John Jayman, Seth D Goldstein, Karl Benz, Timothy Baumgartner, John P Gearhart
INTRODUCTION: Cloacal exstrophy (CE) is a severe midline congenital abnormality that requires numerous surgical corrections to achieve an acceptable quality of life. Candidates for urinary continence undergo multiple procedures, most often continent bladder diversions, to become socially dry. Here, the authors investigate the number of genitourinary interventions that patients with CE undergo to attain urinary continence. MATERIALS AND METHODS: A retrospective review of a prospectively maintained database of 1311 exstrophy epispadias complex patients was performed...
February 24, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29553950/the-emerging-role-of-immunotherapy-in-advanced-urothelial-cancers
#11
William Tabayoyong, Jianjun Gao
PURPOSE OF REVIEW: Recent Food and Drug Administration (FDA) approval of five new immune checkpoint inhibitors for the treatment of metastatic urothelial cancer represents the first major treatment breakthrough for this disease since the introduction of combination chemotherapy over 30 years ago. This review examines the recent clinical trials leading to FDA approval of these agents, the current challenges facing immunotherapy and areas that require further research. RECENT FINDINGS: The programmed death 1 receptor (PD-1) and its ligand programmed death ligand-1 (PD-L1) are important negative regulators of immune activity, preventing destruction of normal tissues and autoimmunity...
May 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29549279/phosphodiesterase-type-4-inhibition-enhances-nitric-oxide-and-hydrogen-sulfide-mediated-bladder-neck-inhibitory-neurotransmission
#12
Ángel Agis-Torres, Paz Recio, María Elvira López-Oliva, María Pilar Martínez, María Victoria Barahona, Sara Benedito, Salvador Bustamante, Miguel Ángel Jiménez-Cidre, Albino García-Sacristán, Dolores Prieto, Vítor S Fernandes, Medardo Hernández
Nitric oxide (NO) and hydrogen sulfide (H2 S) play a pivotal role in nerve-mediated relaxation of the bladder outflow region. In the bladder neck, a marked phosphodiesterase type 4 (PDE4) expression has also been described and PDE4 inhibitors, as rolipram, produce smooth muscle relaxation. This study investigates the role of PDE4 isoenzyme in bladder neck gaseous inhibitory neurotransmission. We used Western blot and double immunohistochemical staining for the detection of NPP4 (PDE4) and PDE4A and organ baths for isometric force recording to roflumilast and tadalafil, PDE4 and PDE5, respectively, inhibitors in pig and human samples...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29530711/mapping-and-neuromodulation-of-lower-urinary-tract-function-using-spinal-cord-stimulation-in-female-rats
#13
Huiyi H Chang, Jih-Chao Yeh, Ronaldo M Ichiyama, Larissa V Rodriguez, Leif A Havton
Spinal cord epidural stimulation (SCS) represents a form of neuromodulation for the management of spasticity and pain. This technology has recently emerged as a new approach for potentially augmenting locomotion and voiding function in humans and rodents after spinal cord injury. However, the effect of SCS on micturition has not been studied extensively. Here, SCS was first applied as a direct stimulus onto individual segmental levels of the lumbar spinal cord in rats to map evoked external urethral sphincter (EUS) electromyography activity and SCS-induced voiding contractions...
March 9, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29527985/surgical-challenge-in-pediatric-kidney-transplant-lower-urinary-tract-abnormality
#14
Atsushi Aikawa, Masaki Muramatsu, Yusuke Takahashi, Yuko Hamasaki, Junya Hashimoto, Mai Kubota, Youji Hyoudou, Yoshihiro Itabashi, Takeshi Kawamura, Seiichiro Shishido
Lower urinary tract abnormalities are difficult to resolve in pediatric kidney transplant patients. Measure of residual urine, voiding cystourethrography, retrograde urethrography, cystometry, electromyography of urethral external sphincter muscle, urethrometry, and uroflowmetry are the primary methods for evaluation of lower urinary tract abnormalities. Endoscopic resection or ablation of urethral valves is required in children with posterior urethral valve to treat obstruction, but bladder function does not always recover and may deteriorate to end-stage renal failure even after the obstruction is released...
March 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29522865/intradetrusor-injections-of-botulinum-toxin-type-a-in-children-with-spina-bifida-a-multicenter-study
#15
Juliette Hascoet, Benoit Peyronnet, Véronique Forin, Maximilien Baron, Grégoire Capon, Thomas Prudhomme, Clément Allenet, Simon Tournier, Charlotte Maurin, Jean-Nicolas Cornu, Ourdia Bouali, Matthieu Peycelon, Alexis Arnaud, Mariette Renaux-Petel, Agnès Liard, Gilles Karsenty, Andrea Manunta, Xavier Game
OBJECTIVE: To assess the effectiveness of intradetrusor injections of botulinum toxin type A (IDBTX-A) in children with spina bifida. METHODS: All patients aged less than 16 years old who underwent IDBTX-A between 2002 and 2016 at 6 institutions were included in a retrospective study. Our primary endpoint was the success rate of IDBTX-A defined as both clinical improvement (no incontinence episodes between clean intermittent catheterizations [CICs], absence of urgency, and less than 8 CICs per day) and urodynamic improvement (resolution of detrusor overactivity and normal bladder compliance for age) lasting ≥12 weeks...
March 6, 2018: Urology
https://www.readbyqxmd.com/read/29511675/regulation-of-spontaneous-contractions-in-intact-rat-bladder-strips-and-the-effects-of-hydrogen-peroxide
#16
Mingshuai Wang, Nianzeng Xing, Liyang Wu, Wen-Chu Huang, Zhenqun Xu, Guiming Liu
Enhanced spontaneous contractions are associated with overactive bladder. Elevated levels of reactive oxygen species might contribute to enhanced spontaneous contractions. We investigated the regulation of spontaneous contractions and the effects of hydrogen peroxide (H2 O2 ) in intact rat bladder strips. The spontaneous contractions were measured using a tissue bath system. The vehicle or the specific activators/blockers were applied and followed by the application of 0.003 g% H2 O2 . The basal tension, amplitude, and frequency of spontaneous contractions were quantified...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29488655/clinical-outcomes-of-non-surgical-management-of-detrusor-leak-point-pressures-above-40-cm-water-in-adults-with-congenital-neurogenic-bladder
#17
Giulia I Lane, Ronak A Gor, Jenna Katorski, Sean P Elliott
AIMS: Neurogenic bladders (NGB) with detrusor leak point pressures >40 cm H2 O (dLPP > 40) have been associated with deterioration of renal function in children with myelomeningocele. For these children, careful pressure management preserves renal function. However, similar evidence is lacking in adult congenital urology (ACU) patients with NGB. We describe renal functional outcomes of non-surgical management of adults with dLPP > 40 or premicturition detrusor pressure (PMDP) >40 cm H2 O, consisting of close follow-up with urodynamic studies (UDS) and renal ultrasound (RUS), paired with adjustments to clean intermittent catheterization (CIC) frequency, anticholinergics, and addition of onabotulinumtoxinA toxin (BTX) injection...
February 28, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29485034/the-use-of-urodynamic-studies-for-the-followup-of-neurogenic-bladders-treated-with-onabotulinumtoxina
#18
Michelle Bergeron, Genevieve Nadeau, Katherine Moore
INTRODUCTION: Intradetrusor injections of onabotulinumtoxinA (BoNTA) is well-established as treatment for patients with neurogenic bladders. Urodynamics (UDS) are used at regular intervals during followup to monitor intravesical pressure. With regards to the discomfort and risks associated with UDS, our objective was to assess if UDS done at regular intervals in the followup of neurogenic bladders treated with BoNTA had an impact on management. METHODS: We retrospectively analyzed the medical records of adult patients with neurologic disorders treated with BoNTA for either detrusor overactivity or low bladder compliance at the Institut de Réadaptation en Déficience Physique de Québec (IRDPQ)...
February 23, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29465789/a-real-world-experience-with-augmentation-enterocystoplasty-high-patient-satisfaction-with-high-complication-rates
#19
Shu-Yu Wu, Hann-Chorng Kuo
AIMS: To investigate the real treatment outcomes after augmentation enterocystoplasty (AE) of patients with refractory neurogenic lower urinary tract dysfunction. METHODS: Retrospective follow-up in a single center. The videourodynamic data, renal function, incontinence grade, voiding pattern and management, clinical outcome, and complications were evaluated. RESULTS: Seventy-nine patients (62 men and 17 women) were included. The mean age at operation was 39...
February 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29459044/decellularized-human-fetal-intestine-as-a-bioscaffold-for-regeneration-of-the-rabbit-bladder-submucosa
#20
Abdol-Mohammad Kajbafzadeh, Reza Khorramirouz, Ahmad Masoumi, Sorena Keihani, Behnam Nabavizadeh
PURPOSE: We aim to report a method to create a natural acellular scaffold from human fetal small intestine for augmentation cystoplasty in rabbits. METHODS: Fetal intestines were decellularized by immersion in a hypotonic solution. The success of this protocol was evaluated by histological analysis, scanning electron microscopy and measurement of collagen and sulfated glycosaminoglycan of the acellular tissues. Eight mature rabbits were selected and acellular scaffolds were implanted on the exposed urothelium...
February 1, 2018: Journal of Pediatric Surgery
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