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bladder augmentation

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https://www.readbyqxmd.com/read/28901710/reduced-urothelial-regeneration-in-rat-bladders-augmented-with-permeable-porcine-small-intestinal-submucosa-assessed-by-magnetic-resonance-imaging
#1
Qing Yang, Ding Xia, Rheal A Towner, Nataliya Smith, Debra Saunders, Kar-Ming Fung, Christopher E Aston, Beverley Greenwood-Van Meerveld, Robert E Hurst, Sundararajan V Madihally, Bradley P Kropp, Hsueh-Kung Lin
Augmentation enterocystoplasty remains the gold standard surgical bladder reconstruction procedure to increase the capacity and compliance of dysfunctional bladders. Since the use of the patient's intestine has severe risks of complications, alternative biodegradable matrices have been explored. Porcine small intestinal submucosa (SIS) has gained immense interests in bladder reconstruction due to its favorable properties. However, trials have shown inconsistent regeneration with SIS, attributed to the heterogeneity in microstructures and mechanical properties...
September 13, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28893918/enterococcus-faecalis-promotes-innate-immune-suppression-and-polymicrobial-catheter-associated-urinary-tract-infection
#2
Brenda Yin Qi Tien, Hwee Mian Sharon Goh, Kelvin Kian Long Chong, Soumili Bhaduri-Tagore, Sarah Holec, Regine Dress, Florent Ginhoux, Molly A Ingersoll, Rohan B H Williams, Kimberly A Kline
Enterococcus faecalis, a member of the human gastrointestinal microbiota, is an opportunistic pathogen associated with hospital-acquired wound, bloodstream, and urinary tract infections. E. faecalis can subvert or evade immune-mediated clearance, although the mechanisms are poorly understood. In this study, we examined E. faecalis-mediated subversion of macrophage activation. We observed that E. faecalis actively prevents NF-κB signaling in mouse RAW264.7 macrophages in the presence of Toll-like receptor agonists and during polymicrobial infection with Escherichia coliE...
September 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28888815/neurogenic-bladder-in-a-girl-after-surgery-for-cloacal-malformation-a-case-for-bladder-augmentation
#3
Candace F Granberg, Patricio C Gargollo
Management of neurogenic bladder in pediatric patients is complex. Treatment options must be individualized to not only address the clinical parameters but also take into account the social factors that directly impact the ability to achieve a successful outcome.
September 6, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28888708/ureteric-urethral-engraftment-as-a-new-surgical-technique-for-management-of-incontinence-in-bladder-exstrophy-complex-a-retrospective-cohort
#4
Abdol-Mohammad Kajbafzadeh, Shabnam Sabetkish, Nastaran Sabetkish
OBJECTIVES: To report the results of a novel surgical technique for achieving urinary continence in patients with bladder exstrophy complex (BEC) by ureteric-urethral engraftment (UUE) technique. PATIENTS AND METHODS: Sixteen female patients with BEC and a mean ± SD age of 3.48 ± 1.75 years were referred for primary exstrophy repair from 2009 to 2012. From these, 9 patients were operated by single-stage bladder closure (group I); while 7 patients underwent the novel technique of UUE to compare the continence achievement (group II)...
September 6, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28883282/development-of-immune-checkpoint-inhibitors
#5
Shigehisa Kitano
Immune checkpoint inhibitors are the most striking innovation in the clinical development of immunotherapy. Monoclonal antibodies (mAbs) restore and augment the antitumor immune activities of cytotoxic T cells by mainly blocking immune checkpoint molecules on T cells or their ligands on antigen-presenting and tumor cells. Based on preclinical data, many clinical trials have demonstrated the acceptable safety profiles and efficacies of mAb in various cancers. The A first-in-class approved immune checkpoint inhibitor is ipilimumab, which is a fully humanized mAb that blocks the immunosuppressive signal by cytotoxic T-lymphocyte antigen 4...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28882559/enhancement-of-s1p-induced-contractile-response-in-detrusor-smooth-muscle-of-rats-having-cystitis
#6
Irfan Anjum, Merve Denizalti, Hilmi Burak Kandilci, Nezahat Tugba Durlu-Kandilci, Inci Sahin-Erdemli
Interstitial cystitis is a chronic disease characterized by lower abdominal pain and some nonspecific symptoms including an increase in urinary frequency and urgency. Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that controls smooth muscle tone via G-protein coupled receptors (S1P1-3 receptors). S1P production is known to take place both in physiological states and some pathological situations, such as in overactive bladder syndrome. The intracellular mechanism of S1P-induced contractile response was investigated in β-escin permeabilized detrusor smooth muscle of rats having cyclophosphamide-induced cystitis...
September 4, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28867481/lesions-of-the-central-amygdala-and-ventromedial-medulla-reduce-bladder-hypersensitivity-produced-by-acute-but-not-chronic-foot-shock
#7
Alan Randich, Cary DeWitte, Jennifer J DeBerry, Meredith T Robbins, Timothy J Ness
Both acute and chronic stress has been shown to exacerbate symptoms of chronic visceral pain conditions such as interstitial cystitis. Studies using animal models support these findings in that both acute and chronic exposure to foot shock-induced stress (FS) augment nociceptive reflex responses to urinary bladder distension (UBD). Only a few studies have examined the neural substrates mediating these phenomena and it is not clear whether acute and chronic stress engage the same or different substrates to produce bladder hypersensitivity...
August 31, 2017: Brain Research
https://www.readbyqxmd.com/read/28861311/our-experiences-with-robot-assisted-laparoscopic-surgery-in-pediatric-patients-the-first-case-series-from-turkey
#8
Yusuf Kibar, Serdar Yalçın, Engin Kaya, Burak Köprü, Turgay Ebiloğlu, Giray Ergin, Hüseyin Tomruk
OBJECTIVE: Robotic surgery is a leading treatment option for minimally invasive surgery and has an increasing popularity in pediatric population, as well. In this article, we reported our case series of robot-assisted laparoscopic surgery in pediatric population. MATERIAL AND METHODS: We retrospectively reviewed 29 consecutive pediatric patients who underwent robot- assisted procedures between May 2014 and October 2016. Patient demographics, hospitalization time, estimated blood loss, robotic time and total operative and peri-, and post-operative complications were evaluated...
September 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28830753/bladder-reconstruction-rates-differ-among-centers-participating-in-national-spina-bifida-patient-registry
#9
Jonathan C Routh, David B Joseph, Tiebin Liu, Michael S Schechter, Judy K Thibadeau, M Chad Wallis, Elisabeth A Ward, John S Wiener
PURPOSE: We performed an exploratory analysis of data from the National Spina Bifida Patient Registry (NSBPR) to assess variation in the frequency of bladder reconstruction surgeries among NSBPR centers. METHODS: We queried the 2009-2014 NSBPR to identify patients who had ever undergone bladder reconstruction surgeries. We evaluated demographic characteristics, SB type, functional level, mobility, and NSBPR center to determine whether any of these factors were associated with reconstructive surgery rates...
August 19, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28827400/upf1-helicase-promotes-tsn-mediated-mirna-decay
#10
Reyad A Elbarbary, Keita Miyoshi, Omar Hedaya, Jason R Myers, Lynne E Maquat
While microRNAs (miRNAs) regulate the vast majority of protein-encoding transcripts, little is known about how miRNAs themselves are degraded. We recently described Tudor-staphylococcal/micrococcal-like nuclease (TSN)-mediated miRNA decay (TumiD) as a cellular pathway in which the nuclease TSN promotes the decay of miRNAs that contain CA and/or UA dinucleotides. While TSN-mediated degradation of either protein-free or AGO2-loaded miRNAs does not require the ATP-dependent RNA helicase UPF1 in vitro, we report here that cellular TumiD requires UPF1...
July 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/28814499/therapeutic-stimulation-for-restoration-of-function-after-spinal-cord-injury
#11
REVIEW
Aiva Ievins, Chet T Moritz
Paralysis due to spinal cord injury can severely limit motor function and independence. This review summarizes different approaches to electrical stimulation of the spinal cord designed to restore motor function, with a brief discussion of their origins and the current understanding of their mechanisms of action. Spinal stimulation leads to impressive improvements in motor function along with some benefits to autonomic functions such as bladder control. Nonetheless, the precise mechanisms underlying these improvements and the optimal spinal stimulation approaches for restoration of motor function are largely unknown...
September 2017: Physiology
https://www.readbyqxmd.com/read/28771836/editorial-comment-to-lessons-learned-from-the-management-of-adults-who-have-undergone-augmentation-for-spina-bifida-and-bladder-exstrophy-incidence-and-management-of-the-non-lethal-complications-of-bladder-augmentation
#12
Kazuyoshi Johnin
No abstract text is available yet for this article.
August 3, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28771821/lessons-learned-from-the-management-of-adults-who-have-undergone-augmentation-for-spina-bifida-and-bladder-exstrophy-incidence-and-management-of-the-non-lethal-complications-of-bladder-augmentation
#13
REVIEW
Douglas A Husmann
The present review provides clinical insights and makes recommendations regarding patient management garnered by the long-term follow up of patients undergoing enteric bladder augmentation for the management of congenital anomalies. A prospectively maintained database on 385 patients that have experienced an enteric bladder augmentation, using either the ileum or colon, was reviewed. Evaluations included methods used to prevent bladder calculi formation and recurrence, the incidence and etiology of renal calculi development, the incidence and treatment of vitamin B12 deficiency, and the complications and need for surgical revisions for continent catheterizable stomas...
August 3, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28762694/pelvic-organ-prolapse
#14
REVIEW
Cheryl B Iglesia, Katelyn R Smithling
Pelvic organ prolapse is the descent of one or more of the anterior vaginal wall, posterior vaginal wall, the uterus (cervix), or the apex of the vagina (vaginal vault or cuff scar after hysterectomy). Prevalence increases with age. The cause of prolapse is multifactorial but is primarily associated with pregnancy and vaginal delivery, which lead to direct pelvic floor muscle and connective tissue injury. Hysterectomy, pelvic surgery, and conditions associated with sustained episodes of increased intra-abdominal pressure, including obesity, chronic cough, constipation, and repeated heavy lifting, also contribute to prolapse...
August 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28756610/treatment-of-obesity-associated-overactive-bladder-by-the-phosphodiesterase-type-4-inhibitor-roflumilast
#15
Honglin Ding, Ning Li, Xiaoning He, Bing Liu, Liming Dong, Yili Liu
PURPOSE: To prove that phosphodiesterase type-4 inhibitors could potentially treat obesity-associated overactive bladder through modulation of the systemic inflammatory response. METHODS: In this 12-week study, 90 female Sprague-Dawley rats were divided into three groups: (1) vehicle-treated normal diet (ND)-fed rats; (2) vehicle-treated high-fat diet (HFD)-fed rats; and (3) roflumilast-treated HFD-fed rats. Oral roflumilast (5 mg/kg/day) was administered during the last 4 weeks of HFD feeding in the test group...
July 29, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28746469/interleukin-27-augments-the-inhibitory-effects-of-sorafenib-on-bladder-cancer-cells
#16
J Y Cao, H S Yin, H S Li, X Q Yu, X Han
Both sorafenib and interleukin-27 (IL-27) are antineoplastic drugs. This study aimed to investigate the synergistic effect of these two drugs on bladder cancer cells. HTB-9 and T24 cells were stimulated with IL-27 (50 ng/mL), sorafenib (2 μM) or the synergistic action of these two drugs. The cells without treatment acted as control. Cell proliferation, apoptosis and invasion were measured by bromodeoxyuridine assay, flow cytometry and modified Boyden chamber, respectively. Simultaneously, both modified Boyden chamber and scratch assay were used to assess cell migration...
July 20, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28743527/effectiveness-and-complications-of-augmentation-cystoplasty-with-or-without-non-refluxing-ureteral-reimplantation-in-adult-patients-with-long-standing-bladder-dysfunction-a-single-center-11-year-experience-in-173-cases
#17
Zhaoxia Wang, Limin Liao
PURPOSE: To review our experience for effectiveness and complications of augmentation cystoplasty (AC) with or without non-refluxing ureteral reimplantation in adult patients with long-standing bladder dysfunction MATERIAL AND METHODS: We retrospectively reviewed 173 patients who underwent AC with or without ureteral re-implantation (UR) at our center from July 2005 to July 2016. Clinical data, magnetic resonance urography (MRU), and video-urodynamics (VUD) parameters were collected. The upper urinary tract dilation (UUTD) and vesicoureteral reflux (VUR) grading systems were used to evaluate upper urinary tract function...
July 22, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28742810/effect-of-calcium-electroporation-in-combination-with-metformin-in-vivo-and-correlation-between-viability-and-intracellular-atp-level-after-calcium-electroporation-in-vitro
#18
Stine Krog Frandsen, Julie Gehl
BACKGROUND: Calcium electroporation is a new experimental anti-cancer treatment where calcium is internalized into cells by application of short, high voltage pulses. Calcium electroporation has been shown to induce tumor necrosis associated with ATP depletion while the effect on normal fibroblasts was limited when investigated in a 3D in vitro spheroid model. We aimed to investigate the effect of calcium electroporation in combination with metformin, a drug that affects intracellular ATP level...
2017: PloS One
https://www.readbyqxmd.com/read/28738532/genipin-attenuates-cisplatin-induced-nephrotoxicity-by-counteracting-oxidative-stress-inflammation-and-apoptosis
#19
Eglal Mahgoub, Shanmugam Muthu Kumaraswamy, Kamal Hassan Kader, Balaji Venkataraman, Shreesh Ojha, Ernest Adeghate, Mohanraj Rajesh
Cisplatin (CP) is a potent and widely used chemotherapeutic agent. However, the clinical benefits of CP are compromised because it elicits nephrotoxicity and ototoxicity. In this study, we investigated the nephroprotective effects of the phytochemical genipin (GP) isolated from the gardenia (Gardenia jasminoides) fruit, using a murine model of CP-induced nephropathy. GP pretreatment attenuated the CP-induced renal tissue injury by diminishing the serum blood urea nitrogen, creatinine, and cystatin C levels, as well as those of kidney injury molecule-1...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28736658/3d-reconstruction-of-cystoscopy-videos-for-comprehensive-bladder-records
#20
Kristen L Lurie, Roland Angst, Dimitar V Zlatev, Joseph C Liao, Audrey K Ellerbee Bowden
White light endoscopy is widely used for diagnostic imaging of the interior of organs and body cavities, but the inability to correlate individual 2D images with 3D organ morphology limits its utility for quantitative or longitudinal studies of disease physiology or cancer surveillance. As a result, most endoscopy videos, which carry enormous data potential, are used only for real-time guidance and are discarded after collection. We present a computational method to reconstruct and visualize a 3D model of organs from an endoscopic video that captures the shape and surface appearance of the organ...
April 1, 2017: Biomedical Optics Express
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