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https://www.readbyqxmd.com/read/28522925/urinary-tract-stone-development-in-patients-with-myelodysplasia-subjected-to-augmentation-cystoplasty
#1
Courtney L Shepard, Guaqiao Wang, Betsy D Hopson, Erika B Bunt, Dean G Assimos
Patients with myelodysplasia who have undergone augmentation cystoplasty are at risk for urinary tract stones. We sought to determine the incidence and risk factors for stone development in this population. The charts of 40 patients with myelodysplasia who have undergone augmentation cystoplasty were reviewed. None had a prior history of urinary tract stones. All patients were seen on an annual basis with plain abdominal imaging, renal ultrasonography, and laboratory testing. Statistical analysis included a multivariable bootstrap resampling method and Student's t-test...
2017: Reviews in Urology
https://www.readbyqxmd.com/read/28498480/miconazole-induces-apoptosis-via-the-death-receptor-5-dependent-and-mitochondrial-mediated-pathways-in-human-bladder-cancer-cells
#2
Sheau-Yun Yuan, Ming-Yuh Shiau, Yen-Chuan Ou, Yu-Chia Huang, Cheng-Che Chen, Chen-Li Cheng, Kun-Yuan Chiu, Shian-Shiang Wang, Kan-Jen Tsai
Miconazole (MIC), an antifungal agent, diplays anti‑tumorigenic activity in various types of human cancers, including bladder cancer, yet its mechanism of antitumor action is not well understood. In the present study, we demonstrated that, in a cell viability assay, MIC had a cytotoxic effect on human T24, J82 and TSGH-8301 bladder cancer cells in a dose- and time‑dependent manner, but did not exhibit significant toxicity toward human peripheral blood mononuclear cells. Cell cycle analysis revealed that MIC at concentrations of 25 and 50 µM significantly caused G0/G1 arrest in the TSGH-8301 and T24 cells, respectively...
April 27, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28478876/metabolic-and-electrolyte-abnormalities-related-to-use-of-bowel-in-urologic-reconstruction
#3
REVIEW
Amanda N Squiers, Karleena Twitchell
Many urologic reconstructive techniques involve the use of autologous bowel for urinary diversion and bladder augmentation. The resection of bowel and its reimplantation into the urinary system often comes with a variety of metabolic and electrolyte derangements, depending on the type of bowel used and the quantity of urine it is exposed to in its final anatomic position. Clinicians should be aware of these potential complications due to the serious consequences that may result from uncorrected electrolyte disturbances...
June 2017: Nursing Clinics of North America
https://www.readbyqxmd.com/read/28467725/feasibility-morbidity-and-functional-results-of-supratrigonal-cystectomy-with-augmentation-ileocystoplasty-by-combined-robotic-assisted-laparoscopy-and-mini-laparotomy-approach
#4
François-Xavier Madec, Oussama Hedhli, Marie-Aimée Perrouin-Verbe, Amelie Levesque, Loic LE Normand, Jérôme Rigaud
OBJECTIVES: Evaluation of the feasibility, morbidity, learning curve and functional results of robotic supratrigonal cystectomy with augmentation ileocystoplasty (RSCAI). MATERIAL AND METHOD: RSCAI was performed in 19 patients between 2012 and 2016. Thirteen patients (66.4%) presented refractory detrusor overactivity (DO) or impaired compliance and 6 patients (31.6%) had painful bladder syndrome. A combined robotic-assisted laparoscopy and mini-laparotomy approach was performed...
May 3, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28462847/breaking-the-ritual-metabolic-cycle-in-order-to-save-acetyl-coa-a-potential-role-for-mitochondrial-humanin-in-t2-bladder-cancer-aggressiveness
#5
Nesreen Nabil Omar, Reham Fathy Tash, Youssef Shoukry, Karim Omar ElSaeed
INTRODUCTION: Cancer cells may exhibit outsourcing of their high energy need in order to avoid the intrinsic mitochondrial apoptosis. Reduced mitochondrial respiration and accumulation of mitochondrial genome mutations are among metabolic transformations in this regard. Mitochondrial humanin (MT-RNR2) is a small peptide with anti-apoptotic activities attributed to binding some pro-apoptotic proteins. AIM OF THE WORK: The current study aims at investigating the expression of mitochondrial humanin in bladder tumor cells and the possible casting of humanin anti-apoptotic action through orchestrating some of the mitochondrial metabolic enzymes...
April 24, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28447605/traumatic-spinal-cord-injury
#6
REVIEW
Christopher S Ahuja, Jefferson R Wilson, Satoshi Nori, Mark R N Kotter, Claudia Druschel, Armin Curt, Michael G Fehlings
Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and vocational well-being of patients. The demographic of SCIs is shifting such that an increasing proportion of older individuals are being affected. Pathophysiologically, the initial mechanical trauma (the primary injury) permeabilizes neurons and glia and initiates a secondary injury cascade that leads to progressive cell death and spinal cord damage over the subsequent weeks. Over time, the lesion remodels and is composed of cystic cavitations and a glial scar, both of which potently inhibit regeneration...
April 27, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28415542/bladder-smooth-muscle-cells-on-electrospun-poly-%C3%AE%C2%B5-caprolactone-poly-l-lactic-acid-scaffold-promote-bladder-regeneration-in-a-canine-model
#7
Nasser Shakhssalim, Masoud Soleimani, Mohammad M Dehghan, Javad Rasouli, Masoud Taghizadeh-Jahed, Peyman M Torbati, Mohammad Naji
Engineering of urinary bladder has been the focus of numerous studies in recent decade. Novel biomaterials, innovative fabrication methods and various modification processes of scaffolds are the critical issues to find supportive matrices. Supportive characteristics of electrospun PCL/PLLA nano-scaffold for bladder augmentation in canine model and the role of bladder cells in regeneration process were appraised. Electrospun PCL/PLLA was fabricated by co-electrospinning of PCL and PLLA. Bladder cells were isolated and transduced with lentiviral particles encoding eGFP and JRed proteins...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28413306/urogenital-management-in-cloaca-an-alternative-approach
#8
Harshjeet Singh Bal, Sudipta Sen, Cenita Sam, Jacob Chacko, John Mathai, S R Regunandan
INTRODUCTION: In the management of cloaca, there is concern that dissection of the urogenital sinus in early childhood with the aim of total anatomical correction is hazardous. Avoiding such mobilization and providing mitrofanoff channel, when needed, till peripubertal period reduces complications and is technically easier. MATERIALS AND METHODS: Forty-three cases of cloaca were managed in the period 2004-2016. Case records and radiology were reviewed retrospectively...
April 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28378811/inhibition-of-pyruvate-kinase-m2-markedly-reduces-chemoresistance-of-advanced-bladder-cancer-to-cisplatin
#9
Xing Wang, Fenglin Zhang, Xue-Ru Wu
Chemoresistance to cisplatin is a principal cause of treatment failure and mortality of advanced bladder cancer (BC). The underlying mechanisms remain unclear, which hinders the development of preventive strategies. Recent data indicate that pyruvate kinase M2 (PKM2), a glycolytic enzyme for Warburg effect, is strongly upregulated in BC. This study explores the role of PKM2 in chemoresistance and whether inhibiting PKM2 augments the chemosensitivity to cisplatin and reduces BC growth and progression. We found that Shikonin binds PKM2 and inhibits BC cell survival in a dose-dependent but pyruvate kinase activity-independent manner...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376513/the-role-of-environmental-stress-on-lower-urinary-tract-symptoms
#10
Melissa T Sanford, Larissa V Rodriguez
PURPOSE OF REVIEW: Lower urinary tract symptoms (LUTS) have been associated with comorbid conditions such as anxiety and depression. In addition, stress appears to influence the development or exacerbation of LUTS. This article seeks to review literature regarding the role of environmental stress on LUTS, focusing on findings presented in the last year. RECENT FINDINGS: Numerous authors have published on the impact early childhood experiences, acute and chronic stress, and psychiatric illness play in the development of LUTS...
May 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28367330/factors-predicting-renal-function-outcome-after-augmentation-cystoplasty
#11
Shahbaz Mehmood, Raouf Seyam, Sadia Firdous, Waleed Mohammad Altaweel
We determined the cause of renal deterioration after augmentation cystoplasty (AC). Twenty-nine adult patients with refractory bladder dysfunction and who underwent ileocystoplasty from 2004 to 2015 were studied. Patients with a decline in glomerular filtration rate (GFR) after augmentation were reviewed. The primary outcome was to determine the factors that might lead to deterioration of estimated GFR. Median follow-up was 7.0 ± 2.6 years. Significant bladder capacity, end filling pressure, and bladder compliance were achieved from median 114 ± 53...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/28339443/clinical-outcome-of-augmentation-enterocystoplasty-for-patients-with-ketamine-induced-cystitis
#12
Yu Khun Lee, Jia-Fong Jhang, Hann-Chorng Kuo
BACKGROUND: Ketamine abuse has become a global phenomenon in recent years. Ketamine-induced cystitis (KC) is a new clinical syndrome which can result in severely inflamed bladder and intractable bladder pain. Currently there is no guideline for managing patients with KC. OBJECTIVES: To analyze the clinical outcome of patients with KC managed with augmentation enterocystoplasty (AE). STUDY DESIGN: Retrospective interventional study. SETTING: A tertiary teaching hospital, Hualien Tzu Chi Hospital...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28328634/bridging-the-gap-engineered-porcine-derived-urinary-bladder-matrix-conduits-as-a-novel-scaffold-for-peripheral-nerve-regeneration
#13
Lyly Nguyen, Ashkan Afshari, Nathaniel D Kelm, Alonda C Pollins, R Bruce Shack, Mark D Does, Wesley P Thayer
PURPOSE: This study aims to compare engineered nerve conduits constructed from porcine-derived urinary bladder matrix (UBM) with the criterion-standard nerve autografts, for segmental loss peripheral nerve repairs. METHODS: Forty-eight Sprague-Dawley rats were divided into 2 groups. All underwent a 10-mm sciatic nerve gap injury. This was repaired using either (1) reverse autograft-the 10-mm cut segment was oriented 180 degrees and used to coapt the proximal and distal stumps or (2) UBM conduit-the 10-mm nerve gap was bridged with UBM conduit...
June 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28328190/effects-of-nitric-oxide-inhibitors-in-mice-with-bladder-outlet-obstruction
#14
Marcy Lancia Pereira, Carlos Arturo Levi D'ancona, Julio Alejandro Rojas-Moscoso, Antonio Celso Saragossa Ramos, Fabiola Zakia Monica, Edson Antunes
PURPOSE: To investigate the lower urinary tract changes in mice treated with L-NAME, a non-selective competitive inhibitor of nitric oxide synthase (NOS), or aminoguanidine, a competitive inhibitor of inducible nitric oxide synthase (iNOS), after 5 weeks of partial bladder outlet obstruction (BOO), in order to evaluate the role of constitutive and non-constitutive NOS in the pathogenesis of this experimental condition. MATERIALS AND METHODS: C57BL6 male mice were partially obstructed and randomly allocated into 6 groups: Sham, Sham + L-NAME, Sham + aminoguanidine, BOO, BOO + L-NAME and BOO + aminoguanidine...
March 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28322621/bladder-regeneration-using-multiple-acellular-scaffolds-with-growth-factors-in-a-bladder
#15
Luc A J Roelofs, Paul K J D de Jonge, Egbert Oosterwijk, Dorien M Tiemessen, Barbara B M Kortmann, Robert P E de Gier, Elly M M Versteeg, Willeke F Daamen, Toin H van Kuppevelt, Paul J Geutjes, Wout F J Feitz
INTRODUCTION: Tissue engineering may become an alternative to current bladder augmentation techniques. Large scaffolds are needed for clinically significant augmentation, but can result in fibrosis and graft shrinkage. The purpose of this study was to investigate the use of multiple scaffolds instead of one large scaffold, to enhance bladder tissue regeneration and bladder capacity. Second, acellular collagen, collagen-heparin, and collagen-heparin scaffolds with growth factors (GFs) were used and the biological activity of the different scaffolds was compared in a large animal model...
May 2, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28283711/the-role-of-reconstructive-surgery-in-patients-with-end-stage-interstitial-cystitis-bladder-pain-syndrome-is-cystectomy-necessary
#16
Elaine J Redmond, Hugh D Flood
INTRODUCTION: Interstitial cystitis is a debilitating condition that has a profound effect on quality of life. Although many approaches to treatment have been explored, no consistently effective treatment has been identified. Reconstructive surgery is offered to patients with refractory IC/BPS; however, expert opinion is divided as to whether simultaneous cystectomy is necessary to achieve symptomatic cure. The aim of this study was to report our experience in the surgical management of IC/BPS in a university teaching hospital...
March 11, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28277472/transvaginal-repair-of-complex-rectovaginal-fistulas-using-the-porcine-urinary-bladder-matrix-as-an-augmenting-graft
#17
Hemikaa Devakumar, Neeraja Chandrasekaran, Alexandriah Alas, Laura Martin, G Willy Davila, Eric Hurtado
BACKGROUND: After the US Food and Drug Administration issued a safety warning concerning vaginal mesh implants in 2008, their use in correction of pelvic floor defects have decreased in the United States (http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm479732.htm). However, we are still treating patients who have had complications associated with their use, rectovaginal fistulas (RVFs) being one of them. Rectovaginal fistulas are considered complex if greater than 2.5 cm, recurrent, associated with inflammatory bowel disease, or if they are proximal in location...
May 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28277297/prevention-of-ventriculoperitoneal-shunt-complications-after-intraperitoneal-urological-surgeries
#18
Takashi Ikeda, Sayaka Akiyama, Woo Jin Kim, Susumu Ito, Yuichiro Yamazaki
PURPOSE: To evaluate perioperative management for the prevention of postoperative shunt infection and malfunction after intraperitoneal urological surgery in patients with myelodysplasia and a ventriculoperitoneal shunt. METHODS: From 2005 to 2015, 20 consecutive patients with myelodysplasia and a ventriculoperitoneal shunt who underwent intraperitoneal urological surgeries were managed with the same perioperative regimen. Intraperitoneal surgeries involved opening gastrointestinal tracts, including bladder augmentation by enterocystoplasty, creating continent catheterizable channels and Malone antegrade continent enema...
October 14, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28274700/commentary-to-outcomes-of-seromuscular-bladder-augmentation-versus-standard-ileocystoplasty-a-single-institution-experience-over-14-years
#19
Martin Kaefer
No abstract text is available yet for this article.
June 16, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28265591/tubulovillous-adenoma-in-the-bladder-in-a-dual-pancreas-kidney-transplant-patient
#20
Taylor Remondini, Stephan Van Zyl, Tarek A Bismar, Serdar Yilmaz, M Eric Hyndman
Background: A rare report of a tubulovillous adenoma arising in the setting of a dual pancreas-kidney transplant patient. Case Presentation: This adenoma was discovered in a 60-year-old male with a dual pancreas-kidney transplant that presented with urinary retention and gross hematuria. Management of this patient required both transurethral resection of the tumor as well as a laparotomy after recurrence. Follow-up with cystoscopy has shown no further recurrence of the tumor. Conclusion: This case adds to the few cases documented of adenomas arising in bladders augmented with gastrointestinal tract tissue...
2017: Journal of Endourology Case Reports
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