keyword
https://read.qxmd.com/read/38547501/contextual-factors-influencing-the-equitable-implementation-of-precision-medicine-in-routine-cancer-care-in-belgium
#1
JOURNAL ARTICLE
Tugce Schmitt, Marie Delnord, Emilie Cauët, Els Van Valckenborgh, Marc Van den Bulcke
BACKGROUND: Precision medicine represents a paradigm shift in health systems, moving from a one-size-fits-all approach to a more individualized form of care, spanning multiple scientific disciplines including drug discovery, genomics, and health communication. This study aims to explore the contextual factors influencing the equitable implementation of precision medicine in Belgium for incorporating precision medicine into routine cancer care within the Belgian health system. METHODS: As part of a foresight study, our approach evaluates critical factors affecting the implementation of precision oncology...
March 28, 2024: European Journal of Public Health
https://read.qxmd.com/read/38547482/a-concept-analysis-of-paternal-bonding-with-prematurely-born-infants
#2
JOURNAL ARTICLE
Nisreen Alnuaimi, Traci Snedden
BACKGROUND: Maternal bonding in infancy has long been the focus of research and practice. Despite emerging evidence highlighting the importance of paternal bonding, little attention has been focused on fathers. Simultaneously, there is little clarity regarding possible differences between bonding and attachment. PURPOSE: This article aims to clarify the concept of paternal bonding with infants born prematurely. METHODS/SEARCH STRATEGY: Using Walker and Avant's approach to concept analysis, we selected databases and searched them for relevant studies published between 2012 and 2022...
April 1, 2024: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://read.qxmd.com/read/38547473/harnessing-the-potential-of-self-assembled-peptide-hydrogels-for-neural-regeneration-and-tissue-engineering
#3
REVIEW
Haniyeh Najafi, Ghazal Farahavar, Mahboobeh Jafari, Samira Sadat Abolmaali, Negar Azarpira, Ali Mohammad Tamaddon
Spinal cord injury, traumatic brain injury, and neurosurgery procedures usually lead to neural tissue damage. Self-assembled peptide (SAP) hydrogels, a type of innovative hierarchical nanofiber-forming peptide sequences serving as hydrogelators, have emerged as a promising solution for repairing tissue defects and promoting neural tissue regeneration. SAPs possess numerous features such as adaptable morphologies, biocompatibility, injectability, tunable mechanical stability, and mimicking of the native extracellular matrix...
March 28, 2024: Macromolecular Bioscience
https://read.qxmd.com/read/38547447/association-of-biomarkers-of-neuronal-injury-and-inflammation-with-insomnia-trajectories-after-traumatic-brain-injury-a-track-tbi-study
#4
JOURNAL ARTICLE
J Kent Werner, Jennifer Albrecht, Vincent F Capaldi, Sonia Jain, Xiaoying Sun, Pratik Mukherjee, Scott G Williams, Jacob Collen, Ramon Diaz-Arrastia, Geoffrey T Manley, Andrew D Krystal, Emerson Wickwire
BACKGROUND AND OBJECTIVES: Insomnia affects about one-third of patients with traumatic brain injury and is associated with worsened outcomes after injury. We hypothesized that higher levels of plasma neuroinflammation biomarkers at the time of TBI would be associated with worse 12-month insomnia trajectories. METHODS: Participants were prospectively enrolled from 18 level-1 trauma centers participating in the Transforming Research and Clinical Knowledge in Traumatic Brain Injury study from February 26, 2014, to August 8, 2018...
April 23, 2024: Neurology
https://read.qxmd.com/read/38547441/association-between-cervical-inflammatory-mediators-and-prevalent-cervical-human-papillomavirus-infection
#5
JOURNAL ARTICLE
Temitope Olukomogbon, Bernice Akpobome, Aderonke Omole, Clement A Adebamowo, Sally N Adebamowo
PURPOSE: Inflammatory mediators are important regulators of immune response and can modulate the inflammation caused by viral infections, including human papillomavirus (HPV). In this study, we evaluated the association between cervical immune mediators, including chemokines, cytokines, and growth factors with HPV infections. MATERIALS AND METHODS: We used a nonmagnetic bead-based multiplex assay to determine 27 immune mediators in cervical secretions collected from 275 women in a prospective longitudinal cohort design...
March 2024: JCO global oncology
https://read.qxmd.com/read/38547423/new-biologics-for-food-allergy
#6
JOURNAL ARTICLE
Jackson P Schuetz, Brent Anderson, Sayantani B Sindher
PURPOSE OF REVIEW: This review aims to explore role of emerging biologics, including ligelizumab, UB-221, dupilumab, and antialarmins, in food allergy management. With a focus on recent developments, we evaluate their promise in mitigating adverse events during oral immunotherapy (OIT), reducing allergic reactions, and addressing the limitations of current therapeutic options. RECENT FINDINGS: Antiimmunoglobulin E mAbs, exemplified by omalizumab, demonstrate efficacy in desensitization and safety improvement during multiallergen OIT...
March 29, 2024: Current Opinion in Allergy and Clinical Immunology
https://read.qxmd.com/read/38547415/an-overview-of-research-for-the-application-of-a-novel-biofilm-preventing-surgical-irrigation-system-for-total-joint-arthroplasty-procedures-in-order-to-reduce-the-risk-of-periprosthetic-infection
#7
JOURNAL ARTICLE
Sean B Sequeira, Matthew F Myntti, Jeanne Lee, Michael A Mont
Periprosthetic joint infection (PJI) is a serious postoperative complication in joint arthroplasty procedures that carries substantial morbidity and mortality associated with it. Several strategies have been developed both in the preoperative, perioperative, and postoperative periods to both combat and prevent the development of this devastating complication. Intraoperative irrigation is an important modality used during arthroplasty procedures prior to the implantation of final components that seeks to eradicate any biofilm formation...
March 28, 2024: Surgical Technology International
https://read.qxmd.com/read/38547410/the-science-of-stapling-staple-form
#8
JOURNAL ARTICLE
Prachi Rojatkar, Anil K Nalagatla, Crystal D Ricketts, Jeffrey W Clymer, Emily Yosh
Surgical stapling has evolved significantly over time, with the primary goal of improving patient outcomes. This study describes the technological advancements in surgical stapling from the perspective of staple and cartridge design, assessing the impact of staple design when it changes from the traditional B form (also known as 2D staple form) to a three-dimensional form (known as 3D staple form). The change in configuration helps compress a larger surface area of the tissue. The 3D configuration is designed to optimize compression not only underneath each staple but also across staples and multiple staple lines, including both stapled and unstapled regions of the tissue...
March 19, 2024: Surgical Technology International
https://read.qxmd.com/read/38547408/oesophageal-fluoroscopy-when-and-why
#9
JOURNAL ARTICLE
Martina Scharitzer, Peter Pokieser, Olle Ekberg
Oesophageal fluoroscopy is a radiological procedure that uses dynamic recording of the swallowing process to evaluate morphology and function simultaneously, a characteristic not found in other clinical tests. It enables a comprehensive evaluation of the entire upper gastrointestinal tract, from the oropharynx to oesophagogastric bolus transport. The number of fluoroscopies of the oesophagus and the oropharynx has increased in recent decades, while the overall use of gastrointestinal fluoroscopic examinations has declined...
March 28, 2024: British Journal of Radiology
https://read.qxmd.com/read/38547377/pleural-mesothelioma-in-situ-a-comprehensive-review
#10
JOURNAL ARTICLE
Federica Danuzzo, Federico Raveglia, Francesca Spinelli, Chiara Maria Sibilia, Enrico Cassina, Lidia Libretti, Emanuele Pirondini, Antonio Tuoro, Francesca Bono, Maria Emilia Paladino, Diego Cortinovis, Francesco Petrella
Pleural mesothelioma is a rare and aggressive cancer that affects the pleura. In recent years, there has been increasing interest and attention in detecting and diagnosing early-stage or precancerous forms of mesothelioma because of its severe prognosis and short life expectancy at the time of diagnosis. Mesothelioma in situ represents a clear opportunity to improve and innovate the diagnostic approach and the multimodality treatment of mesothelioma: the diagnosis of pleural mesothelioma at the 'in-situ phase' means early disease detection and thus paves the way to new possible curable strategies...
March 11, 2024: European Journal of Cancer Prevention
https://read.qxmd.com/read/38547373/application-of-metabolomics-across-the-spectrum-of-pulmonary-and-critical-care-medicine
#11
JOURNAL ARTICLE
Catherine E Simpson, Julie G Ledford, Gang Liu
In recent years, metabolomics, the systematic study of small molecule metabolites in biological samples, has yielded fresh insights into the molecular determinants of pulmonary diseases and critical illness. The purpose of this article is to orient the reader to this emerging field by discussing the fundamental tenets underlying metabolomics research, the tools and techniques that serve as foundational methodologies, and the various statistical approaches to analysis of metabolomics datasets. We present several examples of metabolomics applied to pulmonary and critical care medicine in order to illustrate the potential of this avenue of research to deepen our understanding of pathophysiology...
March 28, 2024: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/38547339/what-s-in-a-cure-designing-a-broad-spectrum-hiv-gene-therapy
#12
JOURNAL ARTICLE
Rachel E Berman, Will Dampier, Michael R Nonnemacher, Brian Wigdahl
PURPOSE OF REVIEW: The leading gene editing strategy for a human immunodeficiency virus type 1 (HIV-1) cure involves the delivery of SaCas9 and two guide RNAs (gRNAs) in an adeno-associated viral (AAV) vector. As a dual-component system, CRISPR is targeted to a genetic locus through the choice of a Cas effector and gRNA protospacer design pair. As CRISPR research has expanded in recent years, these components have been investigated for utilization in cure strategies, which will be discussed in this article...
March 4, 2024: Current Opinion in HIV and AIDS
https://read.qxmd.com/read/38547329/monitoring-coeliac-disease-in-2024-time-to-change-practice
#13
JOURNAL ARTICLE
Suneil A Raju, Mohamed G Shiha, Hugo A Penny
PURPOSE OF REVIEW: Persistent villous atrophy is associated with morbidity in coeliac disease and most commonly due to ongoing gluten ingestion. Current methods for assessing gluten exposure and persisting villous atrophy include dietary questionnaires and repeat duodenal biopsy, which have limited accuracy or are invasive. This review discusses adjunctive and/or novel tests that could be used to overcome these challenges. RECENT FINDINGS: Small bowel capsule endoscopy is well tolerated and helps to evaluate for persisting villous atrophy and importantly, complications associated with coeliac disease...
March 14, 2024: Current Opinion in Gastroenterology
https://read.qxmd.com/read/38547313/distribution-of-2-2-5-5-tetrachlorobiphenyl-pcb52-metabolites-in-adolescent-rats-after-acute-nose-only-inhalation-exposure
#14
JOURNAL ARTICLE
Amanda J Bullert, Xueshu Li, Binita Gautam, Hui Wang, Andrea Adamcakova-Dodd, Kai Wang, Peter S Thorne, Hans-Joachim Lehmler
Inhalation of PCB-contaminated air is increasingly recognized as a route for PCB exposure. Because limited information about the disposition of PCBs following inhalation exposure is available, this study investigated the disposition of 2,2',5,5'-tetrachlorobiphenyl (PCB52) and its metabolites in rats following acute, nose-only inhalation of PCB52. Male and female Sprague-Dawley rats (50-58 days of age, 210 ± 27 g; n = 6) were exposed for 4 h by inhalation to approximately 14 or 23 μg/kg body weight of PCB52 using a nose-only exposure system...
March 28, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38547293/selection-of-experience-for-memory-by-hippocampal-sharp-wave-ripples
#15
JOURNAL ARTICLE
Wannan Yang, Chen Sun, Roman Huszár, Thomas Hainmueller, Kirill Kiselev, György Buzsáki
Experiences need to be tagged during learning for further consolidation. However, neurophysiological mechanisms that select experiences for lasting memory are not known. By combining large-scale neural recordings in mice with dimensionality reduction techniques, we observed that successive maze traversals were tracked by continuously drifting populations of neurons, providing neuronal signatures of both places visited and events encountered. When the brain state changed during reward consumption, sharp wave ripples (SPW-Rs) occurred on some trials, and their specific spike content decoded the trial blocks that surrounded them...
March 29, 2024: Science
https://read.qxmd.com/read/38547237/the-mechanism-of-cytoplasmic-incompatibility-is-conserved-in-wolbachia-bearing-aedes-aegypti-mosquitoes-deployed-for-arbovirus-control
#16
JOURNAL ARTICLE
Rupinder Kaur, Cole J Meier, Elizabeth A McGraw, Julian F Hillyer, Seth R Bordenstein
The rising interest and success in deploying inherited microorganisms and cytoplasmic incompatibility (CI) for vector control strategies necessitate an explanation of the CI mechanism. Wolbachia-induced CI manifests in the form of embryonic lethality when sperm from Wolbachia-bearing testes fertilize eggs from uninfected females. Embryos from infected females however survive to sustain the maternally inherited symbiont. Previously in Drosophila melanogaster flies, we demonstrated that CI modifies chromatin integrity in developing sperm to bestow the embryonic lethality...
March 28, 2024: PLoS Biology
https://read.qxmd.com/read/38547229/feasibility-of-using-low-cost-markerless-motion-capture-for-assessing-functional-outcomes-after-lower-extremity-musculoskeletal-cancer-surgery
#17
JOURNAL ARTICLE
Sherron Furtado, Brook Galna, Alan Godfrey, Lynn Rochester, Craig Gerrand
BACKGROUND: Physical limitations are frequent and debilitating after sarcoma treatment. Markerless motion capture (MMC) could measure these limitations. Historically expensive cumbersome systems have posed barriers to clinical translation. RESEARCH QUESTION: Can inexpensive MMC [using Microsoft KinectTM] assess functional outcomes after sarcoma surgery, discriminate between tumour sub-groups and agree with existing assessments? METHODS: Walking, unilateral stance and kneeling were measured in a cross-sectional study of patients with lower extremity sarcomas using MMC and standard video...
2024: PloS One
https://read.qxmd.com/read/38547207/effects-of-the-momentum-project-on-postpartum-family-planning-norms-and-behaviors-among-married-and-unmarried-adolescent-and-young-first-time-mothers-in-kinshasa-a-quasi-experimental-study
#18
JOURNAL ARTICLE
Anastasia J Gage, Francine E Wood, Rianne Gay, Pierre Akilimali
This study evaluated the effect of Momentum-an integrated family planning, maternal and newborn health, and nutrition intervention-on postpartum family planning norms and behaviors among ever married and never-married first-time mothers age 15-24 in Kinshasa, Democratic Republic of the Congo. Using data collected in 2018 and 2020, we conducted an intent-to-treat analysis among 1,927 first-time mothers who were about six-months pregnant at enrollment. Difference-in-differences models were run for panel data and treatment effects models with inverse-probability weighting for endline-only outcomes...
2024: PloS One
https://read.qxmd.com/read/38547177/the-socioeconomic-impact-of-the-covid-19-lockdown-on-families-affected-by-childhood-respiratory-illnesses-in-cape-town-south-africa
#19
JOURNAL ARTICLE
Michaile G Anthony, Graeme Hoddinott, Margaret Van Niekerk, Isabelle Dewandel, Carla McKenzie, Carien Bekker, Helena Rabie, Andrew Redfern, Marieke M van der Zalm
The COVID-19 pandemic impacted families globally, directly and indirectly. Children presenting with respiratory illnesses are affected by emerging health systems and socioeconomic changes in the COVID-19 era. We explored the socioeconomic impacts of the COVID-19 lockdown on families with a respiratory illness diagnosed in their child in Cape Town, South Africa. This study was nested in a prospective observational cohort of children presenting with respiratory symptoms presumptive of COVID-19. We conducted 21 semi-structured interviews to explore the socioeconomic impact of the COVID-19 pandemic on families with a child affected by respiratory illnesses...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38547137/balancing-the-uncertain-and-unpredictable-nature-of-possible-zoonotic-disease-transmission-with-the-value-placed-on-animals-findings-from-a-qualitative-study-in-guinea
#20
JOURNAL ARTICLE
Tilly A Gurman, Kendela Diallo, Elizabeth Larson, Kathryn Sugg, Natalie Tibbels
Zoonoses, or diseases that pass between animals and humans, represent a major threat to global health and global economies. In Guinea, zoonotic diseases (e.g. rabies, Lassa fever) have been at the forefront due to recent outbreaks and government priorities. Much like many other diseases, zoonotic disease prevention demands a thorough and culturally nuanced understanding of the factors that influence preventive behaviors. To gain this knowledge and enhance risk communication for priority zoonotic diseases, this qualitative study conducted focus group discussions, in-depth interviews, and observations in three Guinean prefectures...
2024: PLOS Glob Public Health
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