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Hamid Riazi

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https://www.readbyqxmd.com/read/27794634/effects-of-static-magnetic-fields-on-the-structure-polymerization-and-bioelectric-of-tubulin-assemblies
#1
Sarah Mousavidoust, Hamid Mobasheri, Gholam Hossein Riazi
Due to widespread exposure of human being to various sources of static magnetic fields (SMF), their effect on the spatial and temporal status of structure, arrangement and polymerization of tubulin was studied at molecular level. The intrinsic fluorescence intensity of tubulin was increased by SMF, indicating the repositioning of tryptophan and tyrosine residues. Circular Dichroism (CD) spectroscopy revealed variations in the ratios of alpha helix, beta and random coil structures of tubulin as a result of exposure to SMF at 100, 200 and 300mT...
October 31, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27638048/appraisal-of-role-of-the-polyanionic-inducer-length-on-amyloid-formation-by-412-residue-1n4r-tau-protein-a-comparative-study
#2
Abolfazl Jangholi, Mohammad Reza Ashrafi-Kooshk, Seyed Shahriar Arab, Gholamhossein Riazi, Farzad Mokhtari, Mansour Poorebrahim, Hamid Mahdiuni, Boris I Kurganov, Ali Akbar Moosavi-Movahedi, Reza Khodarahmi
In many neurodegenerative diseases, formation of protein fibrillar aggregates has been observed as a major pathological change. Neurofibrillary tangles, mainly composed of fibrils formed by the microtubule-associated protein; Tau, are a hallmark of a group of neurodegenerative diseases such as Alzheimer's disease. Tau belongs to the class of natively unfolded proteins and partially folds into an ordered β-structure during aggregation. Polyanionic cofactors such as heparin are commonly used as inducer of Tau aggregation in vitro...
November 1, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27563424/neuroprotective-effects-of-herbal-extract-rosa-canina-tanacetum-vulgare-and-urtica-dioica-on-rat-model-of-sporadic-alzheimer-s-disease
#3
Parvaneh Daneshmand, Kioomars Saliminejad, Marzieh Dehghan Shasaltaneh, Koorosh Kamali, Gholam Hossein Riazi, Reza Nazari, Pedram Azimzadeh, Hamid Reza Khorram Khorshid
BACKGROUND: Sporadic Alzheimer's Disease (SAD) is caused by genetic risk factors, aging and oxidative stresses. The herbal extract of Rosa canina (R. canina), Tanacetum vulgare (T. vulgare) and Urtica dioica (U. dioica) has a beneficial role in aging, as an anti-inflammatory and anti-oxidative agent. In this study, the neuroprotective effects of this herbal extract in the rat model of SAD was investigated. METHODS: The rats were divided into control, sham, model, herbal extract -treated and ethanol-treated groups...
July 2016: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/26894600/valproic-acid-may-exerts-its-cytotoxic-effect-through-rassf1a-expression-induction-in-acute-myeloid-leukemia
#4
Zare-Abdollahi Davood, Safari Shamsi, Hamid Ghaedi, Riazi-Isfahani Sahand, Ghadyani Mojtaba, Tabarraee Mahdi, Mirfakhraie Reza, Mohammad Javad Ebrahimi, Reyhaneh Sadat Miri-Moosavi, Sara Boosaliki, Omrani Mir Davood
In acute myeloid leukemia (AML), despite the acceptance of standard intensive chemotherapy as an optimal induction regimen for all age groups, in the elderly patients, the best treatment should meet the challenge of multiple factors like age, comorbidities, and cytogenetics, making them ineligible for standard induction chemotherapy. Using the current low-intensity therapies like decitabine, azacitidine, and low-dose cytarabine as a single arm, outcomes for these patients remain poor. As a histone deacetylase inhibitor valproic acid (VPA) exhibit anticancer activity by triggering apoptosis, the mechanism of which is not yet completely clarified...
August 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26568759/comparison-of-lifestyle-in-fertile-and-infertile-couples-in-kermanshah-during-2013
#5
Tahereh Khosrorad, Mahrokh Dolatian, Hedyeh Riazi, Zohreh Mahmoodi, Hamid Alavimajd, Soodeh Shahsavari, Mitra Bakhtiari
BACKGROUND: Infertility is a major reproductive health in gynecology. According to the world health organization, there are currently 50-80 million infertile couples in the world. OBJECTIVE: Considering the critical effects of lifestyle on reproductive health, this study aimed to compare the lifestyle of fertile and infertile couples in Kermanshah during 2013. MATERIALS AND METHODS: This research is a descriptive cross sectional study that was done on 216 fertile and infertile couples attending Infertility Center and six medical centers that were selected through the convenience sampling...
September 2015: Iranian Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/26155505/focal-choroidal-excavation-in-best-vitelliform-macular-dystrophy-case-report
#6
Mohammad Riazi Esfahani, Hamid Riazi Esfahani, Alireza Mahmoudi, Mohammad Karim Johari, Karim Hemati
Focal choroidal excavation (FCE) was first reported as a choroidal posteriorly excavated zone without any scleral change. Choroidal excavation also divided into conforming and nonconforming type. Numerous reports demonstrated association between FCE and other disease such as choroidal neovascularization and central serous choroidoretinopathy. Here, we report a rare case of FCE in a patient with Best disease. The patient was diagnosed by spectoral domain optical coherence tomography (SD-OCT). To the best of our knowledge, our patient is the second report of choroidal excavation in Best vitelliform macular dystrophy...
May 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25709777/visual-prostheses-the-enabling-technology-to-give-sight-to-the-blind
#7
REVIEW
Mohammad Hossein Maghami, Amir Masoud Sodagar, Alireza Lashay, Hamid Riazi-Esfahani, Mohammad Riazi-Esfahani
Millions of patients are either slowly losing their vision or are already blind due to retinal degenerative diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) or because of accidents or injuries. Employment of artificial means to treat extreme vision impairment has come closer to reality during the past few decades. Currently, many research groups work towards effective solutions to restore a rudimentary sense of vision to the blind. Aside from the efforts being put on replacing damaged parts of the retina by engineered living tissues or microfabricated photoreceptor arrays, implantable electronic microsystems, referred to as visual prostheses, are also sought as promising solutions to restore vision...
October 2014: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/25709773/photodynamic-therapy-and-intravitreal-bevacizumab-with-versus-without-triamcinolone-for-neovascular-age-related-macular-degeneration-a-randomized-clinical-trial
#8
Niloofar Piri, Hamid Ahmadieh, Ramin Taei, Masoud Soheilian, Reza Karkhaneh, Alireza Lashay, Faegheh Golbafian, Mehdi Yaseri, Mohammad Riazi-Esfahani
PURPOSE: To compare the outcomes of photodynamic therapy (PDT) combined with intravitreal bevacizumab (IVB) with versus without intravitreal triamcinolone (IVT) in neovascular age-related macular degeneration (AMD). METHODS: Eighty-four eyes with active CNV secondary to AMD with no prior treatment were enrolled and followed for 1-year. Eligible eyes were randomly assigned to either PDT/IVB or PDT/IVB/IVT. The main outcome measure was change in best-corrected visual acuity (BCVA)...
October 2014: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/25264927/malignant-peripheral-nerve-sheath-tumor-of-lacrimal-nerve-a-case-report
#9
Mohammad Taher Rajabi, Hamid Riazi, Seyedeh Simindokht Hosseini, Mohammad Bagher Rajabi, Mehdi Mazloumi, Golnaz Gharehbaghi, Fahimeh Asadi Amoli
BACKGROUND: Orbital and periorbital presentation is rare for malignant peripheral nerve sheath tumors. These tumors are poorly defined spindle cell neoplasms of peripheral nerves and have not been reported to develop in the lacrimal gland to date. AIM: To report a rare presentation of malignant peripheral nerve sheath tumor in the orbital cavity. CASE REPORT: A 65-year-old man was admitted with the chief complaint of prominent right eye. His symptoms began 16 months prior to his admission...
February 2015: Orbit
https://www.readbyqxmd.com/read/24128898/technetium-99m-methoxyisobutylisonitrile-scintigraphy-in-the-assessment-of-cold-thyroid-nodules-is-it-time-to-change-the-approach-to-the-management-of-cold-thyroid-nodules
#10
Ahmad Riazi, Mohammadreza Kalantarhormozi, Iraj Nabipour, Seyed S Eghbali, Mohammadreza Farzaneh, Hamid Javadi, Afshin Ostovar, Mohammad Seyedabadi, Majid Assadi
BACKGROUND: Scanning with technetium-99m methoxyisobutylisonitrile (Tc-MIBI) is recommended for evaluating thyroid nodule metabolism. In addition, it may help differentiate between benign and malignant nodules; however, the efficacy of this technique has not been fully elucidated. Therefore, it is not currently performed for routine clinical application. This prospective study was conducted to investigate the clinical significance of Tc-MIBI scintigraphy in the assessment of patients with cold thyroid nodules...
January 2014: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/23479530/intravitreal-bevacizumab-versus-combined-bevacizumab-and-triamcinolone-acetonide-for-neovascular-age-related-macular-degeneration
#11
Mohammad Riazi-Esfahani, Hamid Ahmadieh, Hooshang Faghihi, Niloofar Piri, Ramin Taei, Reza Karkhaneh, Zahra Alami-Harandi, Alireza Lashay, Ahmad Mirshahi, Mehdi Nili-Ahmadabadi, Masoud Soheilian, Masoumeh Sanagou
PURPOSE: To compare the short-term outcomes of intravitreal bevacizumab (IVB) with the combination of IVB and intravitreal triamcinolone acetonide (IVB/IVT) for treatment of neovascular age-related macular degeneration (AMD). METHODS: This randomized clinical trial was performed on 92 eyes of 90 patients with subfoveal and juxtafoveal choroidal neovascularization (CNV) secondary to AMD. The eyes were randomly assigned to receive IVB 1.25 mg alone (53 eyes) or in combination with IVT 2 mg (39 eyes)...
April 2008: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/22947226/molecular-epidemiology-of-cutaneous-leishmaniasis-and-heterogeneity-of-leishmania-major-strains-in-iran
#12
Hamid Mahmoudzadeh-Niknam, Soheila Ajdary, Farhad Riazi-Rad, Ebrahim Mirzadegan, Abdolhossein Rezaeian, Vahid Khaze, Navid D Djadid, Mohammad H Alimohammadian
Objective  To determine the geographical distribution of Leishmania species causing cutaneous leishmaniasis (CL) and to study the genetic heterogeneity of Leishmania major isolates from different endemic areas of Iran. Methods  A total of 341 isolates from lesions of patients living in 11 provinces of Iran were grown in culture medium and inoculated to BALB/c mice to detect possible visceralisation. The species were identified by isoenzyme analysis using a battery of six enzymes and kinetoplast (k) DNA-PCR technique...
November 2012: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/22936512/concurrent-papillary-thyroid-cancer-and-parathyroid-adenoma-as-a-rare-condition-a-case-report
#13
Hamid Javadi, Sara Jallalat, Shokrollah Farrokhi, Shahriar Semnani, Mehdi Mogharrabi, Ahmad Riazi, Iraj Nabipour, Darab Moshtaghi, Majid Assadi
Although the pathological relationship between parathyroid and thyroid diseases is common, an association between parathyroid adenoma and thyroid cancer is rare. Concomitant thyroid cancer in patients with primary hyperparathyroidism (pHPT) has been reported at varying frequencies. WE present here a 23-year-old man who had papillary thyroid carcinoma in the right thyroid lobe and a parathyroid adenoma in the left thyroid lobe, which were confirmed surgically.
August 25, 2012: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/22214203/disruption-of-tubulin-polymerization-and-cell-proliferation-by-1-naphthylarsonic-acid
#14
Roya Mahinpour, Gholamhossein Riazi, Mohammad A Shokrgozar, Mohammad N Sarbolouki, Shahin Ahmadian, Masoumeh Douraghi, Hamid Hadi Alijanvand, Kayhan Azadmanesh, Maryam Heidari, Zahra Naghdi Gheshlaghi, Ali A Moosavi-Movahedi
Arsenical compounds exhibit a differential toxicity to cancer cells. Microtubules are a primary target of a number of anticancer drugs, such as arsenical compounds. The interaction of 1-NAA (1-naphthylarsonic acid) has been investigated on microtubule polymerization under in vitro and cellular conditions. Microtubules were extracted from sheep brain. Transmission electron microscopy was used to show microtubule structure in the presence of 1-NAA. Computational docking method was applied for the discovery of ligand-binding sites on the microtubular proteins...
April 1, 2012: Cell Biology International
https://www.readbyqxmd.com/read/22173217/memantine-for-axonal-loss-of-optic-neuritis
#15
RANDOMIZED CONTROLLED TRIAL
Mohammad Riazi Esfahani, Zahra Alami Harandi, Morteza Movasat, Mojgan Nikdel, Mohsen Adelpour, Arezo Momeni, Hamid Merat, Masoud Aghsaei Fard
BACKGROUND: To determine the effect of memantine on axonal loss and visual function during the course of optic neuritis (ON). METHODS: Sixty ON patients in a single-center, institutional setting were randomly assigned to the memantine or placebo groups. Patients with first attack of acute unilateral optic neuritis, with visual symptoms of 8 days' duration or less were enrolled in this trial. No patient had known multiple sclerosis, and none had taken immunomodulatory agent prior to or at the time of presentation...
June 2012: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/21555967/intravitreal-bevacizumab-versus-combined-intravitreal-bevacizumab-and-triamcinolone-for-neovascular-age-related-macular-degeneration-six-month-results-of-a-randomized-clinical-trial
#16
RANDOMIZED CONTROLLED TRIAL
Hamid Ahmadieh, Ramin Taei, Mohammad Riazi-Esfahani, Niloufar Piri, Mansour Homayouni, Narsis Daftarian, Mehdi Yaseri
PURPOSE: To determine whether combined intravitreal bevacizumab (IVB) and triamcinolone (IVT) is more effective than IVB alone in neovascular age-related macular degeneration. METHODS: This was a prospective, randomized clinical trial performed at two centers. Eligible eyes were assigned randomly to one of the two study arms. In the IVB group, 3 consecutive injections of 1.25 mg of bevacizumab were given 6 weeks apart, while in the IVB/IVT group, the first of the triple IVB injections was combined with 2 mg of IVB...
October 2011: Retina
https://www.readbyqxmd.com/read/21337043/intravitreal-bevacizumab-vs-sham-treatment-in-acute-branch-retinal-vein-occlusion-with-macular-edema-results-at-3%C3%A2-months-report-1
#17
RANDOMIZED CONTROLLED TRIAL
Siamak Moradian, Hooshang Faghihi, Babak Sadeghi, Niloofar Piri, Hamid Ahmadieh, Masoud Soheilian, Mohammad Hossein Dehghan, Mohsen Azarmina, Mohammad Riazi Esfahani
BACKGROUND: The goal of this work is to compare the visual and anatomical (central macular thickness; CMT) outcomes of intravitreal bevacizumab (IVB) injections relative to sham treatment in eyes with acute (less than 3 months in duration) branch retinal vein occlusion (BRVO). METHODS: In a double-masked randomized clinical trial (RCT), patients with acute BRVO were randomly assigned to one of two treatment groups: IVB (two injections of 1.25 mg IVB 6 weeks apart) or sham treatment...
February 2011: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/19251422/design-and-synthesis-of-4-methoxyphenylacetic-acid-esters-as-15-lipoxygenase-inhibitors-and-sar-comparative-studies-of-them
#18
COMPARATIVE STUDY
Hamid Sadeghian, Neda Attaran, Zeinab Jafari, Mohammad Reza Saberi, Seyed Mohammad Seyedi, Hossein Eshghi, Mehdi Pordel, Mohammad Mahdi Riazi
A group of 4-methoxyphenylacetic acid esters were designed, synthesized and evaluated as potential inhibitors of soybean 15-lipoxygenase (SLO) on the basis of eugenol and esteragol structures. Compounds 7d-e showed the best IC(50) in SLO inhibition (IC(50)=3.8 and 1.9 microM, respectively). All compounds were docked in SLO active site and showed that carbonyl group of compounds is oriented toward the Fe(III)-OH moiety in the active site of enzyme and fixed by hydrogen bonding with hydroxyl group. It is assumed that lipophilic interaction of ligand-enzyme would be in charge of inhibiting the enzyme activity...
March 15, 2009: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/19157886/design-synthesis-and-sar-studies-of-4-allyoxyaniline-amides-as-potent-15-lipoxygensae-inhibitors
#19
Seyed Mohammad Seyedi, Hossein Eshghi, Zeinab Jafari, Neda Attaran, Hamid Sadeghian, Mohammad Reza Saberi, Mohammad Mahdi Riazi
A group of 4-allyloxyaniline amides 5a-o were designed, synthesized and evaluated as potential inhibitors of soybean 15-lipoxygenase (SLO) on the basis of eugenol and esteragol structures. Compound 5e showed the best IC(50) in SLO inhibition (IC(50)=0.67+/-0.06 microM). All compounds were docked in SLO active site retrieved from RCSB Protein Data Bank (PDB entry: 1IK3) and showed that allyloxy group of compounds is oriented towards the Fe(3+)-OH moiety in the active site of enzyme and fixed by hydrogen bonding with two conserved His(513) and Gln(716)...
February 15, 2009: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/17998164/design-and-synthesis-of-eugenol-derivatives-as-potent-15-lipoxygenase-inhibitors
#20
Hamid Sadeghian, Seyed Mohammad Seyedi, Mohammad Reza Saberi, Zahra Arghiani, Mehdi Riazi
A group of 4-allyl-2-methoxyphenol (eugenol) esters were designed, synthesized, and evaluated as potential inhibitors of soybean 15-lipoxygenase (SLO). Compounds 4c, 4d 4f, 4p, and 4q showed the best IC(50) in SLO inhibition (IC(50)=1.7, 2.3, 2.1, 2.2, and 0.017microM, respectively). All compounds were docked into SLO active site and showed that allyl group of compounds is oriented toward the iron atom in the active site of SLO. It is assumed that lipophilic interaction of ligand-enzyme would be in charge of inhibiting the enzyme activity...
January 15, 2008: Bioorganic & Medicinal Chemistry
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