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https://www.readbyqxmd.com/read/29331065/component-resolved-diagnostics-to-direct-in-venom-immunotherapy-important-steps-towards-precision-medicine
#1
Simon Blank, Maria Beatrice Bilò, Markus Ollert
Stings of Hymenoptera can induce IgE-mediated systemic and even fatal allergic reactions. Venom-specific immunotherapy (VIT) is the only disease-modifying and curative treatment of venom allergy. However, choosing the correct venom for VIT represents a necessary prerequisite for efficient protection against further anaphylactic sting reactions after VIT. In the past, therapeutic decisions based on the measurement of specific IgE (sIgE) levels to whole venom extracts were not always straightforward, especially when the patient was not able to identify the culprit insect...
January 13, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29330349/pharmacologic-inhibition-of-phospholipase-c-in-the-brain-attenuates-early-memory-formation-in-the-honeybee-apis-mellifera-l
#2
Shota Suenami, Shiori Iino, Takeo Kubo
Although the molecular mechanisms involved in learning and memory in insects have been studied intensively, the intracellular signaling mechanisms involved in early memory formation are not fully understood. We previously demonstrated that phospholipase C epsilon (PLCe), whose product is involved in calcium signaling, is almost selectively expressed in the mushroom bodies, a brain structure important for learning and memory in the honeybee. Here, we pharmacologically examined the role of phospholipase C (PLC) in learning and memory in the honeybee...
January 12, 2018: Biology Open
https://www.readbyqxmd.com/read/29325460/targeted-delivery-of-melittin-to-cancer-cells-by-as1411-anti-nucleolin-aptamer
#3
Seyed Hossein Rajabnejad, Ahad Mokhtarzadeh, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani, Bibi Marjan Razavi
Melittin, a small water-soluble cationic amphipathic α-helical linear peptide, consisted of 26 amino acids, is the honeybee venom major constituent. Several reports have proved the lytic and apoptotic effects of melittin in several cancerous cell lines. In this study, we aimed to fabricate an AS1411 aptamer-melittin to specifically deliver melittin to nucleolin positive cells (A549). Melittin was covalently attached to antinucleolin aptamer (AS1411) and its toxicity in A549 (Nucleolin positive) and L929 (Nucleolin negative) was studied using MTT and Annexin V flow cytometry methods...
January 12, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29323206/effects-of-bt-cabbage-pollen-on-the-honeybee-apis-mellifera-l
#4
Dengxia Yi, Zhiyuan Fang, Limei Yang
Honeybees may be exposed to insecticidal proteins from transgenic plants via pollen during their foraging activity. Assessing effects of such exposures on honeybees is an essential part of the risk assessment process for transgenic Bacillus thuringiensis (Bt) cabbage. Feeding trials were conducted in a laboratory setting to test for possible effects of Cry1Ba3 cabbage pollen on Italian-derived honeybees Apis mellifera L. Newly emerged A. mellifera were fed transgenic pollen, activated Cry1Ba3 toxin, pure sugar syrup (60% w/v sucrose solution), and non-transgenic cabbage pollen, respectively...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322776/altered-serum-metabolite-profiling-and-relevant-pathways-analysis-in-rats-stimulated-by-honeybee-venom-a-new-insight-into-allergy-to-honeybee-venom
#5
Yazhou Zhao, Jianmei Zhang, Yanping Chen, Zhiguo Li, Hongyi Nie, Wenjun Peng, Songkun Su
To improve our understanding of the disturbed metabolic pathways and cellular responses triggered by honeybee venom stimulation, we compared the changes in serum metabolites rats, either stimulated or not by honeybee venom by performing 1H NMR spectrometry-based metabonomics to identify potential biomarkers. In this study, 65 metabolites were structurally confirmed and quantified and the following results were obtained. Firstly, by pattern recognition analysis, 14 metabolites were selected as potential biomarkers 3 hrs after venom stimulation...
January 11, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29313450/response-to-tennekes-2018-the-resilience-of-the-beehive-journal-of-toxicology-and-environmental-health-b-20-316-386
#6
Keith R Solomon, Gladys L Stephenson
This paper is a response to a letter from Dr. H Tennekes ("The Resilience of the Beehive" Journal of Toxicology and Environmental Health B 20: 316-386). Here we emphasize that our quantitative weight of evidence analyses were focused on the level of the honeybee colony. These colony-level responses include redundancy and resiliency as well as a number of possible sublethal effects of pesticides on the colony. We also note that the literature has shown that binding of neonicotinoid insecticides to the nicotinic acetylcholine receptor is reversible...
January 9, 2018: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/29302217/caffeic-acid-phenethyl-ester-protects-against-photothrombotic-cortical-ischemic-injury-in-mice
#7
Sun Ae Hwang, Chi Dae Kim, Won Suk Lee
In this study, we aimed to investigate the neuroprotective effects of caffeic acid phenethyl ester (CAPE), an active component of propolis purified from honeybee hives, on photothrombotic cortical ischemic injury in mice. Permanent focal ischemia was achieved in the medial frontal and somatosensory cortices of anesthetized male C57BL/6 mice by irradiation of the skull with cold light laser in combination with systemic administration of rose bengal. The animals were treated with CAPE (0.5-5 mg/kg, i.p.) twice 1 and 6 h after ischemic insult...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29301368/antimicrobial-activities-of-european-propolis-collected-from-various-geographic-origins-alone-and-in-combination-with-antibiotics
#8
Issam Al-Ani, Stefan Zimmermann, Jürgen Reichling, Michael Wink
Background: Propolis consists of a complex mixture of resinous substances collected by honeybees from different plant sources. The objective of this study was to investigate the chemical composition, biological activities, and synergistic properties with antibiotics of propolis samples collected from various geographic origins (Germany, Ireland, and Czech Republic). Methods: The chemical composition of the propolis was analyzed by Gas Liquid Chromatography-Mass Spectrometry (GLC-MS) and High-performance liquid chromatography (HPLC)...
January 3, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29301269/enhancing-of-osseointegration-with-propolis-loaded-tio%C3%A2-nanotubes-in-rat-mandible-for-dental-implants
#9
Nithideth Somsanith, Yu-Kyoung Kim, Young-Seok Jang, Young-Hee Lee, Ho-Keun Yi, Jong-Hwa Jang, Kyoung-A Kim, Tae-Sung Bae, Min-Ho Lee
TiO₂ nanotubes (TNT) formation is beneficial for improving bone cell-material interaction and drug delivery for Ti dental implants. Among the natural drugs to be installed in TNT, selected propolis has antibacterial and anti-inflammatory properties. It is a resinous natural product which is collected by the honeybees from the various types of plants with their salivary enzymes. This study concludes that TNT loaded with a propolis (PL-TNT-Ti) dental implant has the ability to improve osseointegration. The propolis particles were embedded within the TNT or adhered to the top...
January 1, 2018: Materials
https://www.readbyqxmd.com/read/29299516/clinical-efficacy-of-a-topical-lactic-acid-bacterial-microbiome-in-chronic-rhinosinusitis-a-randomized-controlled-trial
#10
Anders Mårtensson, Milad Abolhalaj, Malin Lindstedt, Anette Mårtensson, Tobias C Olofsson, Alejandra Vásquez, Lennart Greiff, Anders Cervin
Objective: A locally disturbed commensal microbiome might be an etiological factor in chronic rhinosinusitis (CRS) in general and in CRS without nasal polyps (CRSsNP) in particular. Lactic acid bacteria (LAB) have been suggested to restore commensal microbiomes. A honeybee LAB microbiome consisting of various lactobacilli and bifidobacteria have been found potent against CRS pathogens in vitro. Recently, we examined effects of single nasal administrations of this microbiome in healthy subjects and found it inert...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29298300/neonicotinoid-residues-in-uk-honey-despite-european-union-moratorium
#11
Ben A Woodcock, Lucy Ridding, Stephen N Freeman, M Gloria Pereira, Darren Sleep, John Redhead, David Aston, Norman L Carreck, Richard F Shore, James M Bullock, Matthew S Heard, Richard F Pywell
Due to concerns over negative impacts on insect pollinators, the European Union has implemented a moratorium on the use of three neonicotinoid pesticide seed dressings for mass-flowering crops. We assessed the effectiveness of this policy in reducing the exposure risk to honeybees by collecting 130 samples of honey from bee keepers across the UK before (2014: N = 21) and after the moratorium was in effect (2015: N = 109). Neonicotinoids were present in about half of the honey samples taken before the moratorium, and they were present in over a fifth of honey samples following the moratorium...
2018: PloS One
https://www.readbyqxmd.com/read/29297160/beneficial-protective-role-of-endogenous-lactic-acid-bacteria-against-mycotic-contamination-of-honeybee-beebread
#12
Irakli Janashia, Yvan Choiset, Damian Jozefiak, Franck Déniel, Emmanuel Coton, Ali Akbar Moosavi-Movahedi, Nina Chanishvili, Thomas Haertlé
The purpose of this article is to reveal the role of the lactic acid bacteria (LAB) in the beebread transformation/preservation, biochemical properties of 25 honeybee endogenous LAB strains, particularly: antifungal, proteolytic, and amylolytic activities putatively expressed in the beebread environment have been studied. Seventeen fungal strains isolated from beebread samples were identified and checked for their ability to grow on simulated beebread substrate (SBS) and then used to study mycotic propagation in the presence of LAB...
January 3, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29291561/occurrence-of-agrochemical-residues-in-beeswax-samples-collected-in-italy-during-2013-2015
#13
Monia Perugini, Serena M R Tulini, Daniela Zezza, Stefano Fenucci, Annamaria Conte, Michele Amorena
Considering the importance of honey bees for pollination activity and biodiversity preservation different studies have dealt with the impact of pesticides on honeybee health. Within the hive, beeswax is a matrix of particular interest because most of the chemicals used in agricultural and beekeeping activities can easily accumulate and persist in this matrix long after treatment has ceased, affecting honeybees survival. However, chemical analyses of pesticide residues in beeswax are not mandatory, so there are no residue limits, for beeswax...
December 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29289011/chromatographic-determination-of-monoterpenes-and-other-acaricides-in-honeybees-prevalence-and-possible-synergies
#14
Konstantinos M Kasiotis, Zampia D Tzouganaki, Kyriaki Machera
No abstract text is available yet for this article.
December 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29275181/crystal-structure-of-cystathionine-%C3%AE-synthase-from-honeybee-apis-mellifera
#15
Paula Giménez-Mascarell, Tomas Majtan, Iker Oyenarte, June Ereño-Orbea, Juraj Majtan, Jaroslav Klaudiny, Jan P Kraus, Luis Alfonso Martínez-Cruz
Cystathionine β-synthase (CBS), the key enzyme in the transsulfuration pathway, links methionine metabolism to the biosynthesis of cellular redox controlling molecules. CBS catalyzes the pyridoxal-5'-phosphate-dependent condensation of serine and homocysteine to form cystathionine, which is subsequently converted into cysteine. Besides maintaining cellular sulfur amino acid homeostasis, CBS also catalyzes multiple hydrogen sulfide-generating reactions using cysteine and homocysteine as substrates. In mammals, CBS is activated by S-adenosylmethionine (AdoMet), where it can adopt two different conformations (basal and activated), but exists as a unique highly active species in fruit fly Drosophila melanogaster...
December 21, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/29273327/quantitative-proteomics-reveals-divergent-responses-in-apis-mellifera-worker-and-drone-pupae-to-parasitization-by-varroa-destructor
#16
Carla Surlis, James C Carolan, Mary Coffey, Kevin Kavanagh
Varroa destructor is a haemophagous ectoparasite of honeybees and is considered a major causal agent of colony losses in Europe and North America. Although originating in Eastern Asia where it parasitizes Apis cerana, it has shifted hosts to the western honeybee Apis mellifera on which it has a greater deleterious effect on the individual and colony level. To investigate this important host-parasite interaction and to determine whether Varroa causes different effects on different castes we conducted a label free quantitative proteomic analysis of Varroa-parasitized and non-parasitized drone and worker Apis mellifera pupae...
December 19, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29261096/novel-design-of-honeybee-inspired-needles-for-percutaneous-procedure
#17
Mohammad Sahlabadi, Parsaoran Hutapea
The focus of this paper is to present new designs of innovative bioinspired needles to be used during percutaneous procedures. Insect stingers have been known to easily penetrate soft tissues. Bioinspired needles mimicking the barbs in a honeybee stinger were developed for a smaller insertion force, which can provide a less invasive procedure. Decreasing the insertion force will decrease the tissue deformation, which is essential for a more accurate targeting. In this study, some design parameters, in particular, barb shape and geometry (i...
December 20, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/29258877/different-response-of-acetylcholinesterases-in-salt-and-detergent-soluble-fractions-of-honeybee-haemolymph-head-and-thorax-after-exposure-to-diazinon
#18
Gordana Glavan, Monika Kos, Janko Božič, Damjana Drobne, Jerica Sabotič, Anita Jemec Kokalj
Organophosphate pesticide diazinon is a specific inhibitor of acetylcholinesterase (AChE), which is a common neurotoxicity biomarker in environmental studies. In honeybees, AChE exists in two forms having different physiological roles, one existing as a soluble form and the other as membrane-bound. In most studies AChE activity has been analysed without paying considerable attention to different forms of AChE. In this study, we exposed honeybees Apis mellifera carnica for 10days to diazinon via oral exposure and analysed the total AChE activities in salt soluble (SS) and detergent soluble (DS) fractions...
December 16, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29247388/transfer-of-the-active-ingredients-of-some-plant-protection-products-from-raspberry-plants-to-beehives
#19
Bartosz Piechowicz, Ewa Szpyrka, Lech Zaręba, Magdalena Podbielska, Przemysław Grodzicki
Plant protection products (PPPs) have been found increasingly in the environment. They pose a huge threat to bees, contributing to honeybee colony losses and consequently to enormous economic losses. Therefore, this field investigation was designed to determine whether their active ingredients (AIs) were transferred from raspberry plants to beehives located in the immediate neighbourhood of the crop and to what extent they were transferred. Every week for 2 months, samples of soil, raspberry leaves, flowers and fruits, worker bees, honeybee brood, and honey were collected and analysed for the presence of propyzamide, chlorpyrifos, iprodione, pyraclostrobin, boscalid, cypermethrin, difenoconazole, azoxystrobin, and pyrimethanil residues...
December 15, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29247217/automated-computer-based-detection-of-encounter-behaviours-in-groups-of-honeybees
#20
Christina Blut, Alessandro Crespi, Danielle Mersch, Laurent Keller, Linlin Zhao, Markus Kollmann, Benjamin Schellscheidt, Carsten Fülber, Martin Beye
Honeybees form societies in which thousands of members integrate their behaviours to act as a single functional unit. We have little knowledge on how the collaborative features are regulated by workers' activities because we lack methods that enable collection of simultaneous and continuous behavioural information for each worker bee. In this study, we introduce the Bee Behavioral Annotation System (BBAS), which enables the automated detection of bees' behaviours in small observation hives. Continuous information on position and orientation were obtained by marking worker bees with 2D barcodes in a small observation hive...
December 15, 2017: Scientific Reports
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