keyword
Keywords "Ketamine" and "traumatic brai...

"Ketamine" and "traumatic brain injury"

https://read.qxmd.com/read/38297827/effects-of-intrathecal-ketamine-on-cerebrospinal-fluid-levels-of-brain-derived-neurotrophic-factor-and-mechanical-allodynia-in-a-rat-model-of-mild-traumatic-brain-injury
#1
JOURNAL ARTICLE
Jiyoun Lee, Soeun Jeon, Nara Kim, Sangmin Choi, Wangseok Do, Jae-Rin Kim, Eunsoo Kim, Jeong-Min Hong, Jiseok Baik
BACKGROUND Ketamine, a compelling candidate for neuropathic pain management, has attracted interest for its potential to elevate brain-derived neurotrophic factor (BDNF) levels. We aimed to assess the effects of intrathecally administered ketamine on the cerebrospinal fluid (CSF) levels of BDNF(c-BDNF) and allodynia in a rat model of traumatic brain injury (TBI). MATERIAL AND METHODS Forty-five rats were divided into 3 groups: sham operation (Group S), untreated TBI (Group T), and ketamine-treated TBI (Group K), with 15 rats in each group...
February 1, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38190220/etomidate-versus-ketamine-as-prehospital-induction-agent-in-patients-with-suspectedsevere-traumatic-brain-injury
#2
JOURNAL ARTICLE
Floor J Mansvelder, Sebastiaan M Bossers, Stephan A Loer, Frank W Bloemers, Esther M M Van Lieshout, Dennis Den Hartog, Nico Hoogerwerf, Joukje van der Naalt, Anthony R Absalom, Saskia M Peerdeman, Carolien S E Bulte, Lothar A Schwarte, Patrick Schober
INTRODUCTION: Severe traumatic brain injury (TBI) is a leading cause of morbidity and mortality among young people around the world. Prehospital care focusses on the prevention and treatment of secondary brain injury and commonly includes tracheal intubation after induction of general anesthesia. The choice of induction agent in this setting is controversial. We therefore investigated the association between the chosen induction medication etomidate versus S(+)-ketamine , and the 30-day mortality in patients with severe TBI who received prehospital airway management in the Netherlands...
January 8, 2024: Anesthesiology
https://read.qxmd.com/read/38091390/memantine-inhibits-cortical-spreading-depolarization-and-improves-neurovascular-function-following-repetitive-traumatic-brain-injury
#3
JOURNAL ARTICLE
Mark A MacLean, Jamil H Muradov, Ryan Greene, Gerben Van Hameren, David B Clarke, Jens P Dreier, David O Okonkwo, Alon Friedman
Cortical spreading depolarization (CSD) is a promising target for neuroprotective therapy in traumatic brain injury (TBI). We explored the effect of NMDA receptor antagonism on electrically triggered CSDs in healthy and brain-injured animals. Rats received either one moderate or four daily repetitive mild closed head impacts (rmTBI). Ninety-three animals underwent craniectomy with electrocorticographic (ECoG) and local blood flow monitoring. In brain-injured animals, ketamine or memantine inhibited CSDs in 44 to 88% and 50 to 67% of cases, respectively...
December 15, 2023: Science Advances
https://read.qxmd.com/read/37966330/association-of-early-dexmedetomidine-utilization-with-clinical-and-functional-outcomes-following-moderate-severe-traumatic-brain-injury-a-transforming-clinical-research-and-knowledge-in-traumatic-brain-injury-study
#4
JOURNAL ARTICLE
Sunny Yang Liu, Margot Kelly-Hedrick, Nancy Temkin, Jason Barber, Jordan Komisarow, Jordan Hatfield, Tetsu Ohnuma, Geoffrey Manley, Miriam M Treggiari, Katharine Colton, Monica S Vavilala, Ramesh Grandhi, Daniel T Laskowitz, Joseph P Mathew, Adrian Hernandez, Michael L James, Karthik Raghunathan, Ben Goldstein, Amy Markowitz, Vijay Krishnamoorthy
OBJECTIVE: To examine early sedation patterns, as well as the association of dexmedetomidine exposure, with clinical and functional outcomes among mechanically ventilated patients with moderate-severe traumatic brain injury (msTBI). DESIGN: Retrospective cohort study with prospectively collected data. SETTING: Eighteen Level-1 Trauma Centers, United States. PATIENTS: Adult (age > 17) patients with msTBI (as defined by Glasgow Coma Scale < 13) who required mechanical ventilation from the Transforming Clinical Research and Knowledge in TBI (TRACK-TBI) study...
November 15, 2023: Critical Care Medicine
https://read.qxmd.com/read/37869749/bedside-to-bench-the-outlook-for-psychedelic-research
#5
REVIEW
Victor P Acero, Emily S Cribas, Kevin D Browne, Olivia Rivellini, Justin C Burrell, John C O'Donnell, Suradip Das, D Kacy Cullen
There has recently been a resurgence of interest in psychedelic compounds based on studies demonstrating their potential therapeutic applications in treating post-traumatic stress disorder, substance abuse disorders, and treatment-resistant depression. Despite promising efficacy observed in some clinical trials, the full range of biological effects and mechanism(s) of action of these compounds have yet to be fully established. Indeed, most studies to date have focused on assessing the psychological mechanisms of psychedelics, often neglecting the non-psychological modes of action...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37627826/effects-of-a-subanesthetic-ketamine-infusion-on-inflammatory-and-behavioral-outcomes-after-closed-head-injury-in-rats
#6
JOURNAL ARTICLE
Haley F Spencer, Martin Boese, Rina Y Berman, Kennett D Radford, Kwang H Choi
Traumatic brain injury (TBI) affects millions of people annually, and most cases are classified as mild TBI (mTBI). Ketamine is a potent trauma analgesic and anesthetic with anti-inflammatory properties. However, ketamine's effects on post-mTBI outcomes are not well characterized. For the current study, we used the Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA), which replicates the biomechanics of a closed-head impact with resulting free head movement. Adult male Sprague-Dawley rats sustained a single-session, repeated-impacts CHIMERA injury...
August 8, 2023: Bioengineering
https://read.qxmd.com/read/37435257/second-generation-parenteral-antipsychotic-olanzapine-as-a-first-line-treatment-for-acute-undifferentiated-agitation-in-the-emergency-department-in-comparison-with-haloperidol
#7
JOURNAL ARTICLE
Adheera P Singh, N T Murali Mohan
Background Acutely agitated patients are common in the emergency department (ED). Given the myriad aetiologies of the clinical conditions that can produce agitation, such a high prevalence is unsurprising. Agitation is a symptomatic presentation, not a diagnosis, secondary to a psychiatric, medical, traumatic, or toxicological condition. Most literature on the emergency management of agitated patients is from psychiatric populations, not generalised to EDs. Benzodiazepines, antipsychotics, and ketamine have been used to treat acute agitation...
June 2023: Curēus
https://read.qxmd.com/read/37423591/traumatic-brain-injury-induced-fear-generalization-in-mice-involves-hippocampal-memory-trace-dysfunction-and-is-alleviated-by-r-s-ketamine
#8
JOURNAL ARTICLE
Josephine C McGowan, Liliana R Ladner, Claire X Shubeck, Juliana Tapia, Christina T LaGamma, Amanda Anqueira-González, Ariana DeFrancesco, Briana K Chen, Holly C Hunsberger, Ezra J Sydnor, Ryan W Logan, Tzong-Shiue Yu, Steven G Kernie, Christine A Denny
INTRODUCTION: Traumatic brain injury (TBI) is a debilitating neurological disorder caused by an impact to the head by an outside force. TBI results in persistent cognitive impairments, including fear generalization, the inability to distinguish between aversive and neutral stimuli. The mechanisms underlying fear generalization have not been fully elucidated, and there are no targeted therapeutics to alleviate this symptom of TBI. METHODS: To identify the neural ensembles mediating fear generalization, we utilized the ArcCreERT2 x enhanced yellow fluorescent protein (EYFP) mice, which allow for activity-dependent labeling and quantification of memory traces...
July 7, 2023: Biological Psychiatry
https://read.qxmd.com/read/37160847/ketamine-use-in-the-intubation-of-critically-ill-children-with-neurological-indications-a-multicenter-retrospective-analysis
#9
JOURNAL ARTICLE
Mervin V Loi, Jan Hau Lee, Jimmy W Huh, Palen Mallory, Natalie Napolitano, Justine Shults, Conrad Krawiec, Asha Shenoi, Lee Polikoff, Awni Al-Subu, Ronald Sanders, Megan Toal, Aline Branca, Lily Glater-Welt, Laurence Ducharme-Crevier, Ryan Breuer, Simon Parsons, Ilana Harwayne-Gidansky, Serena Kelly, Makoto Motomura, Kelsey Gladen, Matthew Pinto, John Giuliano, Gokul Bysani, John Berkenbosch, Katherine Biagas, Kyle Rehder, Mioko Kasagi, Anthony Lee, Philipp Jung, Rakshay Shetty, Vinay Nadkarni, Akira Nishisaki
BACKGROUND: Ketamine has traditionally been avoided for tracheal intubations (TIs) in patients with acute neurological conditions. We evaluate its current usage pattern in these patients and any associated adverse events. METHODS: We conducted a retrospective observational cohort study of critically ill children undergoing TI for neurological indications in 53 international pediatric intensive care units and emergency departments. We screened all intubations from 2014 to 2020 entered into the multicenter National Emergency Airway Registry for Children (NEAR4KIDS) registry database...
May 9, 2023: Neurocritical Care
https://read.qxmd.com/read/37089345/efficacy-of-combined-subanesthetic-ketamine-infusion-and-cervical-sympathetic-blockade-as-a-symptomatic-treatment-of-ptsd-tbi-in-a-special-forces-patient-with-a-1-year-follow-up-a-case-report
#10
Eugene Lipov, Zubin Sethi, Guriqbal Nandra, Christopher Frueh
Co-occurrence of posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) symptoms are particularly prevalent in the special operations forces' community, along with other related conditions (e.g., endocrine dysregulation, sleep disorders, chronic pain). Ketamine infusion (KI) has been shown to increase neuroplasticity as well as memory improvement and cervical sympathetic block (CSB) has been shown to improve cognitive function, reduce sympathetic overactivity, and improve other symptoms of PTSD...
April 2023: Heliyon
https://read.qxmd.com/read/37083682/improving-neurotrauma-by-depolarization-inhibition-with-combination-therapy-a-phase-2-randomized-feasibility-trial
#11
JOURNAL ARTICLE
Jed A Hartings, Jens P Dreier, Laura B Ngwenya, Ramani Balu, Andrew P Carlson, Brandon Foreman
BACKGROUND: Spreading depolarizations (SDs) are a pathological mechanism that mediates lesion development in cerebral gray matter. They occur in ∼60% of patients with severe traumatic brain injury (TBI), often in recurring and progressive patterns from days 0 to 10 after injury, and are associated with worse outcomes. However, there are no protocols or trials suggesting how SD monitoring might be incorporated into clinical management. OBJECTIVE: To determine the feasibility and efficacy of implementing a treatment protocol for intensive care of patients with severe TBI that is guided by electrocorticographic monitoring of SDs...
April 21, 2023: Neurosurgery
https://read.qxmd.com/read/37052437/the-evolution-of-ketamine-in-severe-pediatric-traumatic-brain-injury-from-contraband-to-promising-neuroprotectant
#12
EDITORIAL
Patrick M Kochanek, Jeremy R Herrmann, Thomas P Bleck
No abstract text is available yet for this article.
May 1, 2023: Critical Care Medicine
https://read.qxmd.com/read/37020715/-2r-6r-hydroxynorketamine-treatment-of-rats-exposed-to-repetitive-low-level-blast-injury
#13
JOURNAL ARTICLE
Georgina Perez Garcia, Gissel M Perez, Rita De Gasperi, Miguel A Gama Sosa, Alena Otero-Pagan, Rania Abutarboush, Usmah Kawoos, Jonathan K Statz, Jacob Patterson, Carolyn W Zhu, Patrick R Hof, David G Cook, Stephen T Ahlers, Gregory A Elder
Many military veterans who experienced blast-related traumatic brain injuries (TBIs) in the conflicts in Iraq and Afghanistan suffer from chronic cognitive and mental health problems, including post-traumatic stress disorder (PTSD). Male rats subjected to repetitive low-level blast exposure develop chronic cognitive and PTSD-related traits that develop in a delayed manner. Ketamine has received attention as a treatment for refractory depression and PTSD. (2R,6R)-hydroxynorketamine [(2R,6R)-HNK] is a ketamine metabolite that exerts rapid antidepressant actions...
2023: Neurotrauma reports
https://read.qxmd.com/read/36909465/traumatic-brain-injury-induced-fear-generalization-in-mice-involves-hippocampal-memory-trace-dysfunction-and-is-alleviated-by-r-s-ketamine
#14
Josephine C McGowan, Liliana R Ladner, Claire X Shubeck, Juliana Tapia, Christina T LaGamma, Amanda Anqueira-Gonz Lez, Ariana DeFrancesco, Briana K Chen, Holly C Hunsberger, Ezra J Sydnor, Ryan W Logan, Tzong-Shiue Yu, Steven G Kernie, Christine A Denny
INTRODUCTION: Traumatic brain injury (TBI) is a debilitating neurological disorder caused by an impact to the head by an outside force. TBI results in persistent cognitive impairments, including fear generalization, the inability to distinguish between aversive and neutral stimuli. The mechanisms underlying fear generalization have not been fully elucidated, and there are no targeted therapeutics to alleviate this symptom of TBI. METHODS: To identify the neural ensembles mediating fear generalization, we utilized the ArcCreER T2 x enhanced yellow fluorescent protein (EYFP) mice, which allow for activity-dependent labeling and quantification of memory traces...
February 27, 2023: bioRxiv
https://read.qxmd.com/read/36825892/acute-effects-of-ketamine-on-intracranial-pressure-in-children-with-severe-traumatic-brain-injury
#15
JOURNAL ARTICLE
Jennifer C Laws, E Haley Vance, Kristina A Betters, Jessica J Anderson, Sydney Fleishman, Christopher M Bonfield, John C Wellons, Meng Xu, James C Slaughter, Dario A Giuse, Neal Patel, Lori C Jordan, Michael S Wolf
OBJECTIVES: The acute cerebral physiologic effects of ketamine in children have been incompletely described. We assessed the acute effects of ketamine on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in children with severe traumatic brain injury (TBI). DESIGN: In this retrospective observational study, patients received bolus doses of ketamine for sedation or as a treatment for ICP crisis (ICP > 20 mm Hg for > 5 min). Administration times were synchronized with ICP and CPP recordings at 1-minute intervals logged in an automated database within the electronic health record...
May 1, 2023: Critical Care Medicine
https://read.qxmd.com/read/36802976/initial-diagnosis-and-management-of-acutely-elevated-intracranial-pressure
#16
REVIEW
Hashim Kareemi, Michael Pratte, Shane English, Ariel Hendin
Acutely elevated intracranial pressure (ICP) may have devastating effects on patient mortality and neurologic outcomes, yet its initial detection remains difficult because of the variety of manifestations that it can cause disease states it is associated with. Several treatment guidelines exist for specific disease processes such as trauma or ischemic stroke, but their recommendations may not apply to other causes. In the acute setting, management decisions must often be made before the underlying cause is known...
July 2023: Journal of Intensive Care Medicine
https://read.qxmd.com/read/36745167/ketofol-as-an-anesthetic-agent-in-patients-with-isolated-moderate-to-severe-traumatic-brain-injury-a-prospective-randomized-double-blind-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Neha Maheswari, Nidhi B Panda, Shalvi Mahajan, Ankur Luthra, Smita Pattnaik, Nidhi Bhatia, Madhivanan Karthigeyan, Narender Kaloria, Rajeev Chauhan, Shiv Soni, Kiran Jangra, Hemant Bhagat
BACKGROUND: The effects of ketofol (propofol and ketamine admixture) on systemic hemodynamics and outcomes in patients undergoing emergency decompressive craniectomy for traumatic brain injury (TBI) are unknown and explored in this study. METHODS: Fifty patients with moderate/severe TBI were randomized to receive ketofol (n=25) or propofol (n=25) for induction and maintenance of anesthesia during TBI surgery. Intraoperative hemodynamic stability was assessed by continuous measurement of mean arterial pressure (MAP) and need for rescue interventions to maintain MAP within 20% of baseline...
January 1, 2023: Journal of Neurosurgical Anesthesiology
https://read.qxmd.com/read/36207491/co-administration-of-ketamine-in-pediatric-patients-with-neurologic-conditions-at-risk-for-intracranial-hypertension
#18
JOURNAL ARTICLE
Vanessa M Mazandi, Shih-Shan Lang, Raphia K Rahman, Akira Nishisaki, Forrest Beaulieu, Bingqing Zhang, Heather Griffis, Alexander M Tucker, Phillip B Storm, Greg G Heuer, Avi A Gajjar, Steve B Ampah, Matthew P Kirschen, Alexis A Topjian, Ian Yuan, Conall Francoeur, Todd J Kilbaugh, Jimmy W Huh
BACKGROUND: Ketamine has traditionally been avoided as an induction agent for tracheal intubation in patients with neurologic conditions at risk for intracranial hypertension due to conflicting data in the literature. The objective of this study was to evaluate and compare the effects of ketamine versus other medications as the primary induction agent on peri-intubation neurologic, hemodynamic and respiratory associated events in pediatric patients with neurologic conditions at risk for intracranial hypertension...
April 2023: Neurocritical Care
https://read.qxmd.com/read/36184822/the-use-of-ketamine-as-a-neuroprotective-agent-following-cardiac-arrest-a-scoping-review-of-current-literature
#19
JOURNAL ARTICLE
Marlena Ornowska, Andrew Wormsbecker, Gary Andolfatto, Tim S Leung, Idan Khan, George Medvedev
AIMS: The objective of this article is to summarize the state of the literature surrounding the use of ketamine as a neuroprotective agent following cardiac arrest. METHODS: Five electronic databases were used to search for studies related to the use of ketamine for neuroprotection following cardiac arrest. This search was performed once in May 2020, and an updated search was conducted in May 2021 and March 2022. RESULTS: All searches combined retrieved 181 results; no clinical trials were identified...
October 2, 2022: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/36046286/ketamine-and-its-emergence-in-the-field-of-neurology
#20
REVIEW
Luis Rueda Carrillo, Klepper Alfredo Garcia, Nilufer Yalcin, Manan Shah
The quest for a safe and effective anesthetic medication in the mid-20th century led to the discovery of CI-581, which was later named ketamine. Ketamine was labeled a "dissociative anesthetic" due to the state of sensory deprivation that it induces in the subjects receiving it. Although it enjoyed widespread use at the beginning of the Vietnam war, its use rapidly waned due to its psychedelic effect and it became more popular as a recreational drug, and in the field of veterinary medicine. However, as we gained more knowledge about its multiple sites of action, it has reemerged as a useful anesthetic/analgesic agent...
July 2022: Curēus
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