keyword
MENU ▼
Read by QxMD icon Read
search

"Ketamine" and "traumatic brain injury"

keyword
https://www.readbyqxmd.com/read/29734230/ketamine-alters-hippocampal-cell-proliferation-and-improves-learning-in-mice-after-traumatic-brain-injury
#1
Austin J Peters, Laura E Villasana, Eric Schnell
BACKGROUND: Traumatic brain injury induces cellular proliferation in the hippocampus, which generates new neurons and glial cells during recovery. This process is regulated by N-methyl-D-aspartate-type glutamate receptors, which are inhibited by ketamine. The authors hypothesized that ketamine treatment after traumatic brain injury would reduce hippocampal cell proliferation, leading to worse behavioral outcomes in mice. METHODS: Traumatic brain injury was induced in mice using a controlled cortical impact injury, after which mice (N = 118) received either ketamine or vehicle systemically for 1 week...
April 30, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29713142/ketamine-ameliorates-oxidative-stress-induced-apoptosis-in-experimental-traumatic-brain-injury-via-the-nrf2-pathway
#2
Jinwei Liang, Shanhu Wu, Wenxi Xie, Hefan He
Background: Ketamine can act as a multifunctional neuroprotective agent by inhibiting oxidative stress, cellular dysfunction, and apoptosis. Although it has been proven to be effective in various neurologic disorders, the mechanism of the treatment of traumatic brain injury (TBI) is not fully understood. The aim of this study was to investigate the neuroprotective function of ketamine in models of TBI and the potential role of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in this putative protective effect...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29569703/histopathological-changes-in-the-choroid-plexus-after-traumatic-brain-injury-in-the-rats-a-histologic-and-immunohistochemical-study
#3
Hüseyin Özevren, Engin Deveci, Mehmet Cudi Tuncer
Traumatic brain injury (TBI) is in part associated with the disruption of the blood-brain barrier. In this study, we analyzed the histopathological changes in E-cadherin and VEGF expression after traumatic brain injury in rats. The rats were divided into 2 groups as the control and the trauma groups. Sprague-Dawley rats were subjected to traumatic brain injury with a weight-drop device using 300 g⁻¹ m weight-height impact. After 5 days of traumatic brain injury, blood samples were taken under ketamine hydroxide anesthesia and biochemical analyzes were performed...
March 23, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29413725/current-practices-and-safety-of-medication-use-during-rapid-sequence-intubation
#4
Christine M Groth, Nicole M Acquisto, Tina Khadem
PURPOSE: Characterize medication practices during and immediately after rapid sequence intubation (RSI) by provider/location and evaluate adverse drug events. MATERIALS AND METHODS: This was a multicenter, observational, cross-sectional study of adult and pediatric intensive care unit and emergency department patients over a 24-h period surrounding first intubation. RESULTS: A total of 404 patients from 34 geographically diverse institutions were included (mean age 58 ± 22 years, males 59%, pediatric 8%)...
June 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29133177/region-specific-alterations-in-astrocyte-and-microglia-morphology-following-exposure-to-blasts-in-the-mouse-hippocampus
#5
Gloria J DeWalt, Biraaj Mahajan, Andrea R Foster, Lauren D E Thompson, Andrew A Marttini, Eric V Schmidt, Sara Mansuri, Dwayne D'Souza, Shama B Patel, Madeline Tenenbaum, Karla I Brandao-Viruet, Dominique Thompson, Bryan Duong, Danica H Smith, Todd A Blute, William D Eldred
Traumatic brain injury (TBI) is a serious public health concern, especially injuries from repetitive insults. The main objective of this study was to immunocytochemically examine morphological alterations in astrocytes and microglia in the hippocampus 48h following a single blast versus multiple blasts in adult C57BL/6 mice. The effects of ketamine and xylazine (KX), two common anesthetic agents used in TBI research, were also evaluated due to the confounding effect of anesthetics on injury outcome. Results showed a significant increase in hypertrophic microglia that was limited to the outer molecular layer of the dentate gyrus, but only in the absence of KX...
January 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/28814247/fluid-and-medication-considerations-in-the-traumatized-patient
#6
Amita Misir
This article reviews fluid therapy and medications in pediatric trauma. For resuscitation in the setting of hemorrhagic shock, isotonic crystalloid solution is the first-line agent of choice. Colloid solutions offer no additional benefit, introduce possible increased risks and cost more than crystalloids. Blood products, starting with pRBCs, should be introduced after 20-40 ml/kg of crystalloid has been administered if there is ongoing need for volume replacement. The use of a massive transfusion protocol of 1:1:1 (if >30 kg) or 30:20:20 (if <30 kg) of pRBCs:FFP:platelets is suggested after an initial 30 ml/kg of pRBcs have been administered...
August 14, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28492297/recent-antiseizure-medications-in-the-intensive-care-unit
#7
Cindy Orinx, Benjamin Legros, Nicolas Gaspard
BACKGROUND: Seizures and status epilepticus (SE), both clinical and subclinical, are frequent in critically ill patients. The list of available antiseizure medications (ASMs) is expanding and now includes older and widely used drugs as well as more recent medications with a better safety and pharmacokinetics profile. METHODS: We review a selection of recent publications about the indications and administration of ASMs in critical care for the prophylaxis and treatment of seizures and SE, focusing on recent ASMs available as intravenous formulation and emphasizing pharmacokinetics and safety issues in relation to several aspects of critical illness...
August 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28045032/mechanical-stress-activates-nmda-receptors-in-the-absence-of-agonists
#8
Mohammad Mehdi Maneshi, Bruce Maki, Radhakrishnan Gnanasambandam, Sophie Belin, Gabriela K Popescu, Frederick Sachs, Susan Z Hua
While studying the physiological response of primary rat astrocytes to fluid shear stress in a model of traumatic brain injury (TBI), we found that shear stress induced Ca2+ entry. The influx was inhibited by MK-801, a specific pore blocker of N-Methyl-D-aspartic acid receptor (NMDAR) channels, and this occurred in the absence of agonists. Other NMDA open channel blockers ketamine and memantine showed a similar effect. The competitive glutamate antagonists AP5 and GluN2B-selective inhibitor ifenprodil reduced NMDA-activated currents, but had no effect on the mechanically induced Ca2+ influx...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27916727/posttraumatic-administration-of-a-sub-anesthetic-dose-of-ketamine-exerts-neuroprotection-via-attenuating-inflammation-and-autophagy
#9
C-Q Wang, Y Ye, F Chen, W-C Han, J-M Sun, X Lu, R Guo, K Cao, M-J Zheng, L-C Liao
As a complex disease, traumatic brain injury (TBI) can result in long-term psychiatric changes and sensorimotor and cognitive impairments. The TBI-induced loss of memory and long-term cognitive dysfunction are related to mechanistic factors including an increased inflammatory response, autophagy, edema, and ischemia. Many published studies have offered evidence for the neuroprotective effects and anti-inflammatory properties of ketamine for TBI patients. Nonetheless, there is a limited understanding of the accurate mechanism that underlies the potential neuroprotective effects of ketamine...
February 20, 2017: Neuroscience
https://www.readbyqxmd.com/read/27704354/differential-diagnostics-of-neoplastic-and-inflammatory-processes-in-the-brain-by-modifications-nmda-receptor-activity-in-blood-cells-with-verapamil-and-ketamine
#10
S P Syatkin, V A Frolov, N Ya Gridina, N G Draguntseva, A S Skorik
For the development of methods of additional differential diagnostics of gliomas of various grades of malignancy and gliomas and local inflammatory processes in the CNS we studied the intensity of aggregation of peripheral blood cells under the influence of channel blockers ketamine and verapamil. In in vitro experiments, verapamil and ketamine in various dilutions (from 10 to 100,000 times) were added to blood samples and the effects of these dilutions on the intensity of blood aggregation in patients with gliomas of different degree of malignancy, traumatic brain injuries, and other types of neurosurgical pathologies were studied...
September 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27291885/changes-in-electrocorticographic-beta-frequency-components-precede-spreading-depolarization-in-patients-with-acute-brain-injury
#11
MULTICENTER STUDY
Daniel N Hertle, Marina Heer, Edgar Santos, Michael Schöll, Christina M Kowoll, Christian Dohmen, Jennifer Diedler, Roland Veltkamp, Rudolf Graf, Andreas W Unterberg, Oliver W Sakowitz
OBJECTIVE: Spreading depolarization (SD) occurs after traumatic brain injury, subarachnoid hemorrhage, malignant hemispheric stroke and intracranial hemorrhage. SD has been associated with secondary brain injury, which can be reduced by ketamine. In this present study frequency bands of electrocorticographic (ECoG) recordings were investigated with regards to SDs. METHODS: A total of 43 patients after acute brain injury were included in this retrospective and explorative study...
July 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27145814/optimizing-sedation-in-patients-with-acute-brain-injury
#12
REVIEW
Mauro Oddo, Ilaria Alice Crippa, Sangeeta Mehta, David Menon, Jean-Francois Payen, Fabio Silvio Taccone, Giuseppe Citerio
Daily interruption of sedative therapy and limitation of deep sedation have been shown in several randomized trials to reduce the duration of mechanical ventilation and hospital length of stay, and to improve the outcome of critically ill patients. However, patients with severe acute brain injury (ABI; including subjects with coma after traumatic brain injury, ischaemic/haemorrhagic stroke, cardiac arrest, status epilepticus) were excluded from these studies. Therefore, whether the new paradigm of minimal sedation can be translated to the neuro-ICU (NICU) is unclear...
May 5, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27122032/susceptibility-of-primary-sensory-cortex-to-spreading-depolarizations
#13
Volodymyr B Bogdanov, Natalie A Middleton, Jeremy J Theriot, Patrick D Parker, Osama M Abdullah, Y Sungtaek Ju, Jed A Hartings, K C Brennan
UNLABELLED: Spreading depolarizations (SDs) are recognized as actors in neurological disorders as diverse as migraine and traumatic brain injury (TBI). Migraine aura involves sensory percepts, suggesting that sensory cortices might be intrinsically susceptible to SDs. We used optical imaging, MRI, and field potential and potassium electrode recordings in mice and electrocorticographic recordings in humans to determine the susceptibility of different brain regions to SDs. Optical imaging experiments in mice under isoflurane anesthesia showed that both cortical spreading depression and terminal anoxic depolarization arose preferentially in the whisker barrel region of parietal sensory cortex...
April 27, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26794250/perfluorocarbon-nvx-108-increased-cerebral-oxygen-tension-after-traumatic-brain-injury-in-rats
#14
Saad H Mullah, Biswajit K Saha, Rania Abutarboush, Peter B Walker, Ashraful Haque, Francoise G Arnaud, Brittany Hazzard, Charles R Auker, Richard M McCarron, Anke H Scultetus, Paula Moon-Massat
BACKGROUND: Hypoxia is a critical secondary injury mechanism in traumatic brain injury (TBI), and early intervention to alleviate post-TBI hypoxia may be beneficial. NVX-108, a dodecafluoropentane perfluorocarbon, was screened for its ability to increase brain tissue oxygen tension (PbtO2) when administered soon after TBI. METHODS: Ketamine-acepromazine anesthetized rats ventilated with 40% oxygen underwent moderate controlled cortical impact (CCI)-TBI at time 0 (T0)...
March 1, 2016: Brain Research
https://www.readbyqxmd.com/read/26647407/ketamine-for-analgosedation-in-the-intensive-care-unit-a-systematic-review
#15
REVIEW
Asad E Patanwala, Jennifer R Martin, Brian L Erstad
OBJECTIVE: To evaluate the evidence for the use of intravenous ketamine for analgosedation in the intensive care unit. METHODS: MEDLINE and EMBASE were queried from inception until July 2015. Search terms used included ketamine, intensive care, and critical care. The search retrieved 584 articles to be screened for inclusion. The intent was to include randomized controlled studies using sustained intravenous infusions (>24 hours) of ketamine in the critically ill patients...
July 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/25881229/systematic-review-and-meta-analysis-of-efficacy-of-mesenchymal-stem-cells-on-locomotor-recovery-in-animal-models-of-traumatic-brain-injury
#16
REVIEW
Weijun Peng, Jing Sun, Chenxia Sheng, Zhe Wang, Yang Wang, Chunhu Zhang, Rong Fan
INTRODUCTION: The therapeutic potential of mesenchymal stem cells (MSCs) for traumatic brain injury (TBI) is attractive. Conducting systematic review and meta-analyses based on data from animal studies can be used to inform clinical trial design. To conduct a systematic review and meta-analysis to (i) systematically review the literatures describing the effect of MSCs therapy in animal models of TBI, (ii) determine the estimated effect size of functional locomotor recovery after experimental TBI, and (iii) to provide empirical evidence of biological factors associated with greater efficacy...
2015: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/25842650/pharmacologic-physiologic-and-psychological-characteristics-associated-with-emergence-delirium-in-combat-veterans
#17
John Tyler Wilson
The goal of this research was to investigate, through active-duty Army anesthesia providers, their perceptions on emergence delirium (ED) in US combat veterans. Specifically, the pharmacologic, physiologic, and psychological characteristics associated with ED. An online survey was sent to all active-duty Army anesthesia providers with a response rate of 34%. Results indicated that the providers overwhelmingly agreed that ED was related to type of anesthetic used (67.1%) with potent inhalational agents and ketamine ranking highest (88...
October 2014: AANA Journal
https://www.readbyqxmd.com/read/25608499/-acute-treatment-of-patients-with-severe-traumatic-brain-injury
#18
REVIEW
T A Juratli, S E Stephan, A E Stephan, S B Sobottka
BACKGROUND: Traumatic brain injury (TBI) is a leading cause of death and permanent disability and a common and important global problem. The contribution of secondary posttraumatic brain damage to overall disability in TBI is significant, underlining the importance of prompt and comprehensive treatment for affected patients. METHODS: This article focuses on current concepts of prehospital and emergency room management of patients with severe TBI to prevent secondary brain injuries...
February 2015: Der Anaesthesist
https://www.readbyqxmd.com/read/25366616/pharmacological-modulation-of-spreading-depolarizations
#19
REVIEW
Renán Sánchez-Porras, Zelong Zheng, Oliver W Sakowitz
Spreading depolarization (SD) is a wave of almost complete depolarization of the neuronal and glial cells. Nowadays there is sufficient evidence demonstrating its pathophysiological effect in migraine with aura, transient global amnesia, stroke, subarachnoid hemorrhage, intracerebral hemorrhage, and traumatic brain injury. In these cases, occurrence of SD has been associated with functional neuronal damage, neuronal necrosis, neurological degeneration, and poor clinical outcome. Animal models show that SD can be modulated by drugs that interfere with its initiation and propagation...
2015: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/25143737/post-traumatic-epilepsy-current-and-emerging-treatment-options
#20
REVIEW
Jerzy P Szaflarski, Yara Nazzal, Laura E Dreer
Traumatic brain injury (TBI) leads to many undesired problems and complications, including immediate and long-term seizures/epilepsy, changes in mood, behavioral, and personality problems, cognitive and motor deficits, movement disorders, and sleep problems. Clinicians involved in the treatment of patients with acute TBI need to be aware of a number of issues, including the incidence and prevalence of early seizures and post-traumatic epilepsy (PTE), comorbidities associated with seizures and anticonvulsant therapies, and factors that can contribute to their emergence...
2014: Neuropsychiatric Disease and Treatment
keyword
keyword
69220
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"