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https://www.readbyqxmd.com/read/27919653/transperineal-biopsies-of-mri-detected-aggressive-index-lesions-in-low-%C3%A2-and-intermediate-risk-prostate-cancer-patients-implications-for-treatment-decision
#1
A Gomez-Iturriaga, F Casquero, J I Lopez, A Urresola, A Ezquerro, D Buscher, P Bilbao, J Crook
PURPOSE: Multiparametric MRI (mpMRI) has a potential role for the identification of aggressive cancer that can be targeted for biopsy. We report the incidence and severity of discordant information between the pathology found on the transrectal ultrasound (TRUS)-guided biopsy and the mpMRI findings in patients with favorable or intermediate-risk prostate cancer referred for brachytherapy. METHODS AND MATERIALS: From March 2014 to September 2015, 10/44 consecutive patients with low- or intermediate-risk prostate cancer referred for brachytherapy presented an aggressive lesion on mpMRI and underwent an MRI-TRUS fusion-guided transperineal biopsy of the index lesion...
December 2, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27910803/the-prognostic-and-predictive-value-of-tmprss2-erg-gene-fusion-and-erg-protein-expression-in-prostate-cancer-biopsies
#2
Kasper Drimer Berg
BACKGROUND: The clinical course of prostate carcinoma (PCa) is very heterogeneous. Consequently, a personalised approach for risk stratification and treatment planning is important. Recently, it has become evident that PCa, also at the genomic level, is heterogeneous. An early and common alteration is the gene fusion between the transmembrane protease serine 2 (TMPRSS2) gene and the v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) gene resulting in expression of the oncoprotein ERG...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27907167/infusion-advancing-discovery-of-fusion-genes-and-chimeric-transcripts-from-deep-rna-sequencing-data
#3
Konstantin Okonechnikov, Aki Imai-Matsushima, Lukas Paul, Alexander Seitz, Thomas F Meyer, Fernando Garcia-Alcalde
Analysis of fusion transcripts has become increasingly important due to their link with cancer development. Since high-throughput sequencing approaches survey fusion events exhaustively, several computational methods for the detection of gene fusions from RNA-seq data have been developed. This kind of analysis, however, is complicated by native trans-splicing events, the splicing-induced complexity of the transcriptome and biases and artefacts introduced in experiments and data analysis. There are a number of tools available for the detection of fusions from RNA-seq data; however, certain differences in specificity and sensitivity between commonly used approaches have been found...
2016: PloS One
https://www.readbyqxmd.com/read/27882057/robotic-assisted-laparoscopic-prostatectomy-performed-after-previous-suprapubic-prostatectomy
#4
Johnson F Tsui, Michael Feuerstein, Seyed Behzad Jazayeri, David B Samadi
Operative management of prostate cancer in a patient who has undergone previous open suprapubic simple prostatectomy poses a unique surgical challenge. Herein, we describe a case of intermediate risk prostate cancer in a man who had undergone simple prostatectomy ten years prior to presentation. The patient was found to have Gleason 7 prostate cancer on MRI fusion biopsy of the prostate for elevated PSA and underwent an uncomplicated robot assisted laparoscopic radical prostatectomy.
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27871829/the-role-of-ipsilateral-and-contralateral-trus-guided-systematic-prostate-biopsy-in-men-with-unilateral-mri-lesion-undergoing-mri-us-fusion-targeted-prostate-biopsy
#5
Darren J Bryk, Elton Llukani, Samir S Taneja, Andrew B Rosenkrantz, William C Huang, Herbert Lepor
OBJECTIVE: To determine how ipsilateral (ipsi) and contralateral (contra) systematic biopsies (SB) impacts detection of clinically significant versus insignificant prostate cancer (PCa) in men with unilateral MRI lesion undergoing MRI fusion target biopsy (MRF-TB). MATERIALS AND METHODS: 211 cases with one unilateral MRI lesion were subjected to SB and MRF-TB. Biopsy tissue cores from the MRF-TB, ipsi-SB and contra-SB were analyzed separately. RESULTS: A direct relationship was observed between MRI suspicious score (SS) and detection of any cancer, Gleason 6 PCa and Gleason > 6 PCa...
November 18, 2016: Urology
https://www.readbyqxmd.com/read/27865106/high-speed-biosensing-strategy-for-non-invasive-profiling-of-multiple-cancer-fusion-genes-in-urine
#6
Kevin M Koo, Eugene J H Wee, Matt Trau
Aberrant chromosal rearrangements, such as the multiple variants of TMPRSS2:ERG fusion gene mutations in prostate cancer (PCa), are promising diagnostic and prognostic biomarkers due to their specific expression in cancerous tissue only. Additionally, TMPRSS2:ERG variants are detectable in urine to provide non-invasive PCa diagnostic sampling as an attractive surrogate for needle biopsies. Therefore, rapid and simplistic assays for identifying multiple urinary TMPRSS2:ERG variants are potentially useful to aid in early cancer detection, immediate patient risk stratification, and prompt personalized treatment...
November 12, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27864107/should-hypoechoic-lesions-on-trus-be-sampled-during-mri-targeted-prostate-biopsy
#7
Nabeel A Shakir, M Minhaj Siddiqui, Arvin K George, Michael Kongnyuy, Richard Ho, Michele Fascelli, Maria J Merino, Baris Turkbey, Peter L Choyke, Bradford J Wood, Peter A Pinto
OBJECTIVES: To determine whether supplemental biopsy of hypoechoic ultrasound lesions (HUL) incidentally found during MRI-transrectal ultrasound (TRUS) fusion-targeted prostate biopsy results in improved prostate cancer (PCa) detection. METHODS: Patients underwent MRI-TRUS targeted biopsy as part of an ongoing prospective trial from August 2007 to February 2015. For men with HUL, the biopsy pathology of HUL and MRI lesions was classified according to the updated 2014 International Society of Urological Pathology (ISUP) grading system...
November 15, 2016: Urology
https://www.readbyqxmd.com/read/27862869/multicentre-evaluation-of-target-and-systematic-biopsies-using-magnetic-resonance-and-ultrasound-image-fusion-guided-transperineal-prostate-biopsy-in-patients-with-a-previous-negative-biopsy
#8
N L Hansen, C Kesch, T Barrett, B Koo, J P Radtke, D Bonekamp, H P Schlemmer, A Y Warren, K Wieczorek, M Hohenfellner, C Kastner, B Hadaschik
OBJECTIVES: To evaluate the detection rates of targeted and systematic biopsies in magnetic resonance (MRI) and transrectal ultrasound (US) image-fusion transperineal prostate biopsy for patients with previous benign transrectal US guided biopsies in two high-volume centres. PATIENTS AND METHODS: Two centre, prospective outcome study of 487 patients with previous benign biopsies that underwent transperineal MRI/US fusion-guided target and systematic saturation biopsy from 2012 to 2015...
November 10, 2016: BJU International
https://www.readbyqxmd.com/read/27861151/deletion-of-18q-is-a-strong-and-independent-prognostic-feature-in-prostate-cancer
#9
Martina Kluth, Maximilian Graunke, Christina Möller-Koop, Claudia Hube-Magg, Sarah Minner, Uwe Michl, Markus Graefen, Hartwig Huland, Raisa Pompe, Frank Jacobsen, Andrea Hinsch, Corinna Wittmer, Patrick Lebok, Stefan Steurer, Franziska Büscheck, Till Clauditz, Waldemar Wilczak, Guido Sauter, Thorsten Schlomm, Ronald Simon
Deletion of 18q recurrently occurs in prostate cancer. To evaluate its clinical relevance, dual labeling fluorescence in-situ hybridization (FISH) using probes for 18q21 and centromere 18 was performed on a prostate cancer tissue microarray (TMA). An 18q deletion was found in 517 of 6,881 successfully analyzed cancers (7.5%). 18q deletion was linked to unfavorable tumor phenotype. An 18q deletion was seen in 6.4% of 4,360 pT2, 8.0% of 1,559 pT3a and 11.8% of 930 pT3b-pT4 cancers (P < 0.0001). Deletions of 18q were detected in 6...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27858090/dramatic-increase-in-the-utilization-of-multiparametric-magnetic-resonance-imaging-for-detection-and-management-of-prostate-cancer
#10
Daniel T Oberlin, David D Casalino, Frank H Miller, Joshua J Meeks
PURPOSE: Multiparametric MRI (mpMRI) of the prostate is an evolving technology that provides functional information of the prostate that helps distinguish benign from malignant lesions. We hypothesized that mpMRI is rapidly adopted in the US to fill the unmet need for a non-invasive, accurate screening tool. The aim of this study is to assess the increasing utilization of mpMRI for the diagnosis and management of prostate cancer. METHODS: We conducted a retrospective review of an institutional clinical data repository of four million patients...
November 17, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27856204/are-dynamic-contrast-enhanced-images-necessary-for-prostate-cancer-detection-on-multiparametric-magnetic-resonance-imaging
#11
Thaís Caldara Mussi, Tatiana Martins, Rodrigo Gobbo Garcia, Renee Zon Filippi, Gustavo Caserta Lemos, Ronaldo Hueb Baroni
BACKGROUND: To compare the results of magnetic resonance imaging (MRI) with and without contrast-enhanced sequences for the detection of clinically significant prostate cancer. The value of contrast in the MRI protocol for the detection of prostate tumors has been discussed in previous studies. MATERIALS AND METHODS: We performed an institutional review board-approved, retrospective study of patients who had undergone prostate MRI followed by fusion biopsy during a 16-month period...
October 18, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27855661/comparison-of-the-complications-of-traditional-12-cores-transrectal-prostate-biopsy-with-image-fusion-guided-transperineal-prostate-biopsy
#12
Haifeng Huang, Wei Wang, Tingsheng Lin, Qing Zhang, Xiaozhi Zhao, Huibo Lian, Hongqian Guo
BACKGROUND: To compare the complications of traditional transrectal (TR) prostate biopsy and image fusion guided transperineal (TP) prostate biopsy in our center. METHODS: Two hundred and fourty-two patients who underwent prostate biopsy from August 2014 to January 2015were reviewed. Among them, 144 patients underwent systematic 12-core transrectal ultrasonography (TRUS) guided prostate biopsy (TR approach) while 98 patients underwent free-hand transperineal targeted biopsy with TRUS and multi-parameter magnetic resonance imaging (mpMRI) fusion images (TP approach)...
November 17, 2016: BMC Urology
https://www.readbyqxmd.com/read/27847972/first-report-of-robot-assisted-transperineal-fusion-versus-off-target-biopsy-in-patients-undergoing-repeat-prostate-biopsy
#13
S Kaufmann, J Mischinger, B Amend, S Rausch, M Adam, M Scharpf, F Fend, U Kramer, M Notohamiprodjo, K Nikolaou, A Stenzl, J Bedke, S Kruck
PURPOSE: To clarify the value of targeted versus off-target biopsies in men with a suspicion of prostate cancer (PC) and a visible lesion in multi-parametric magnetic resonance imaging (mpMRI) using transperineal robot-assisted biopsy. METHODS: Fifty-five consecutive men with one non-palpable suspicious lesion in mpMRI after negative 12-core transrectal ultrasound-guided biopsy were enrolled in 2014-2015. Lesions were scored using the Prostate Imaging Reporting and Data System...
November 15, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27844131/-mri-trus-fusion-guided-prostate-biopsy-value-in-the-context-of-focal-therapy
#14
T Franz, J von Hardenberg, A Blana, H Cash, D Baumunk, G Salomon, B Hadaschik, T Henkel, J Herrmann, F Kahmann, K-U Köhrmann, J Köllermann, S Kruck, U-B Liehr, S Machtens, I Peters, J P Radtke, A Roosen, H-P Schlemmer, L Sentker, J J Wendler, U Witzsch, J-U Stolzenburg, M Schostak, R Ganzer
BACKGROUND: Several systems for MRI/TRUS fusion-guided biopsy of the prostate are commercially available. Many studies have shown superiority of fusion systems for tumor detection and diagnostic quality compared to random biopsy. The benefit of fusion systems in focal therapy of prostate cancer (PC) is less clear. OBJECTIVES: Critical considerations of fusion systems for planning and monitoring of focal therapy of PC were investigated. MATERIALS AND METHODS: A systematic literature review of available fusion systems for the period 2013-5/2016 was performed...
November 14, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27832183/tumor-cell-derived-exosomes-from-the-prostate-cancer-cell-line-tramp-c1-impair-osteoclast-formation-and-differentiation
#15
Terese Karlsson, Marie Lundholm, Anders Widmark, Emma Persson
Skeletal metastatic disease is a deleterious consequence of dissemination of tumor cells from numerous primary sites, such as prostate, lung and breast. Skeletal metastases are still incurable, resulting in development of clinical complications and decreased survival for cancer patients with metastatic disease. During the last decade, tumor cell-derived microvesicles have been identified and suggested to be involved in cancer disease progression. Whether cancer exosomes are involved in tumor and bone cell interactions in the metastatic site is still, however, a rather unexplored field...
2016: PloS One
https://www.readbyqxmd.com/read/27830373/precision-of-mri-ultrasound-fusion-biopsy-in-prostate-cancer-diagnosis-an-ex-vivo-comparison-of-alternative-biopsy-techniques-on-prostate-phantoms
#16
N Westhoff, F P Siegel, D Hausmann, M Polednik, J von Hardenberg, M S Michel, M Ritter
PURPOSE: Comparing the accuracy of MRI/ultrasound-guided target-biopsy by transrectal biopsy (TRB) with elastic versus rigid image fusion versus transperineal biopsy (TPB) with rigid image fusion in a standardized setting. METHODS: Target-biopsy of six differently sized and located lesions was performed on customized CIRS 070L prostate phantoms. Lesions were only MRI-visible. After prior MRI for lesion location, one targeted biopsy per lesion was obtained by TRB with elastic image fusion with Artemis™ (Eigen, USA), TRB with rigid image fusion with real-time virtual sonography (Hitachi, Japan) and TPB with rigid image fusion with a brachytherapy approach (Elekta, Sweden), each on a phantom of 50, 100 and 150 ml prostate volume...
November 9, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27822437/identification-of-mutations-gene-expression-changes-and-fusion-transcripts-by-whole-transcriptome-rnaseq-in-docetaxel-resistant-prostate-cancer-cells
#17
Yuanjun Ma, Yali Miao, Zhuochun Peng, Johanna Sandgren, Teresita Díaz De Ståhl, Mikael Huss, Lena Lennartsson, Yanling Liu, Monica Nistér, Sten Nilsson, Chunde Li
Docetaxel has been the standard first-line therapy in metastatic castration resistant prostate cancer. The survival benefit is, however, limited by either primary or acquired resistance. In this study, Du145 prostate cancer cells were converted to docetaxel-resistant cells Du145-R and Du145-RB by in vitro culturing. Next generation RNAseq was employed to analyze these cell lines. Forty-two genes were identified to have acquired mutations after the resistance development, of which thirty-four were found to have mutations in published sequencing studies using prostate cancer samples from patients...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27815922/erratum-to-tmprss2-erg-fusion-gene-occurs-less-frequently-in-chinese-patients-with-prostate-cancer
#18
Hui Jiang, Xueying Mao, Xiaoyi Huang, Jing Zhao, Lumei Wang, Jingjing Xu, Hongwei Zhang, Yongjie Lu, Yongwei Yu
No abstract text is available yet for this article.
October 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27815070/direct-detection-of-serca-calcium-transport-and-small-molecule-inhibition-in-giant-unilamellar-vesicles
#19
Tengfei Bian, Joseph M Autry, Denise Casemore, Ji Li, David D Thomas, Gaohong He, Chengguo Xing
We have developed a charge-mediated fusion method to reconstitute the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) in giant unilamellar vesicles (GUV). Intracellular Ca(2+) transport by SERCA controls key processes in human cells such as proliferation, signaling, and contraction. Small-molecule effectors of SERCA are urgently needed as therapeutics for Ca(2+) dysregulation in human diseases including cancer, diabetes, and heart failure. Here we report the development of a method for efficiently reconstituting SERCA in GUV, and we describe a streamlined protocol based on optimized parameters (e...
December 9, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27814612/mirnas-as-drivers-of-tmprss2-erg-negative-prostate-tumors-in-african-american-men
#20
Clayton Yates, Mark D Long, Moray J Campbell, Lara Sucheston-Campbell
African Americans (AAs) who have PCa typically have more aggressive disease and make up a disproportionate number of the disease deaths, relative to European Americans (EAs). TMPRSS2 translocations, a common event in EA patients, are exploited in diagnostic and prognostic settings, whereas they are diminished in frequency in AA men. Thus, these patients with TMPRSS2 fusion-negative disease represent an under-investigated patient group. We propose that epigenetic events are a significant and alternative driver of aggressive disease in fusion-negative PCa...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
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