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https://www.readbyqxmd.com/read/28222486/accuracy-of-real-time-magnetic-resonance-imaging-transrectal-ultrasound-fusion-image-guided-transperineal-target-biopsy-with-needle-tracking-with-a-mechanical-position-encoded-stepper-in-detecting-significant-prostate-cancer-in-biopsy-na%C3%A3-ve-men
#1
Sunao Shoji, Shinichiro Hiraiwa, Takahiro Ogawa, Masayoshi Kawakami, Mayura Nakano, Kazunobu Hashida, Yoshinobu Sato, Terumitsu Hasebe, Toyoaki Uchida, Takuma Tajiri
OBJECTIVE: To evaluate the accuracy of real-time elastic fusion image-guided transperineal prostate biopsy with needle tracking involving a mechanical position-encoded stepper in detecting clinically significant prostate cancer for biopsy-naïve men. METHODS: We prospectively recruited patients with serum prostate-specific antigen levels of 4.0-20 ng/mL and suspicious of prostate cancer on multiparametric magnetic resonance imaging. They underwent targeted biopsies for cancer-suspicious lesions and 12-core systematic biopsies...
February 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28220802/the-prostate-cancer-prevention-trial-risk-calculator-2-0-performs-equally-for-standard-biopsy-and-mri-us-fusion-guided-biopsy
#2
M Maruf, M Fascelli, A K George, M M Siddiqui, M Kongnyuy, J M DiBianco, A Muthigi, S Valayil, A Sidana, T P Frye, A Kilchevsky, P L Choyke, B Turkbey, B J Wood, P A Pinto
BACKGROUND: The Prostate Cancer Prevention Trial Risk Calculator 2.0 (PCPTRC) is a widely used risk-based calculator used to assess a man's risk of prostate cancer (PCa) before biopsy. This risk calculator was created from data of a patient cohort undergoing a 6-core sextant biopsy, and subsequently validated in men undergoing 12-core systematic biopsy (SBx). The accuracy of the PCPTRC has not been studied in patients undergoing magnetic resonance imaging/ultrasound (MRI/US) fusion-guided biopsy (FBx)...
February 21, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28216939/prostatic-intraepithelial-neoplasia-like-ductal-prostatic-adenocarcinoma-a-case-suitable-for-active-surveillance
#3
Soroush Rais-Bahrami, Melissa R Dillard, Grace G Zhu, Jennifer B Gordetsky
In contrast to typical prostatic ductal adenocarcinoma, prostatic intraepithelial neoplasia (PIN)-like ductal adenocarcinoma is a rare variant of prostate cancer with low-grade clinical behavior. We report a case of a 66-year-old African-American male with an elevated serum prostate-specific antigen who underwent multiparametric prostate magnetic resonance imaging (MRI) and MRI/ultrasound fusion-guided biopsies. Pathology demonstrated low-volume Gleason score 3 + 3 = 6 (Grade Group 1), acinar adenocarcinoma involving one core and PIN-like ductal adenocarcinoma on a separate core...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28216280/tmprss2-erg-fusion-in-an-uncommon-presentation-of-prostate-cancer
#4
Nabil Adra, Liang Cheng, Nasser H Hanna, Greg Durm
No abstract text is available yet for this article.
February 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28193277/anti-tumor-effects-of-a-recombinant-anti-prostate-specific-membrane-antigen-immunotoxin-against-prostate-cancer-cells
#5
Ping Meng, Qing-Chuan Dong, Guang-Guo Tan, Wei-Hong Wen, He Wang, Geng Zhang, Yan-Zhu Wang, Yu-Ming Jing, Chen Wang, Wei-Jun Qin, Jian-Lin Yuan
BACKGROUND: To evaluate anti-prostate cancer effects of a chimeric tumor-targeted killer protein. METHODS: We established a novel fusion gene, immunocasp-3, composed of NH2-terminal leader sequence fused with an anti-prostate-specific membrane antigen (PSMA) antibody (J591), the furin cleavage sequences of diphtheria toxin (Fdt), and the reverse coding sequences of the large and small subunits of caspase-3 (revcaspase-3). The expressing level of the immunocasp-3 gene was evaluated by using the reverse transcription-PCR (RT-PCR) and western blot analysis...
February 13, 2017: BMC Urology
https://www.readbyqxmd.com/read/28179286/italian-prostate-biopsies-group-2016-updated-guidelines-insights
#6
REVIEW
Andrea Fandella, Vincenzo Scattoni, Andrea Galosi, Pietro Pepe, Michelangelo Fiorentino, Caterina Gaudiano, Marco Giampaoli, Roberta Gunelli, Pasquale Martino, Vittorino Montanaro, Rodolfo Montironi, Tiziana Pierangeli, Armando Stabile, Alessandro Bertaccini
AIM: To present a summary of the updated guidelines of the Italian Prostate Biopsies Group following the best recent evidence of the literature. MATERIALS AND METHODS: A systematic review of the new data emerging from 2012-2015 was performed by a panel of 14 selected Italian experts in urology, pathology and radiology. The experts collected articles published in the English-language literature by performing a search using Medline, EMBASE and the Cochrane Library database...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28163032/impact-of-gleason-subtype-on-prostate-cancer-detection-using-multiparametric-mri-correlation-with-final-histopathology
#7
Matthew Truong, Gary Hollenberg, Eric Weinberg, Edward M Messing, Hiroshi Miyamoto, Thomas P Frye
PURPOSE: Our purpose was to determine whether Gleason pattern 4 architecture impacts tumor visibility on multiparametric (mpMRI) and correlate with final histopathology. MATERIALS AND METHODS: A total of 83 tumor foci were identified within 22 radical prostatectomy specimens from patients with a prior negative biopsy who underwent MR/US fusion biopsy followed by radical prostatectomy from January 2015-July 2016. A genitourinary pathologist re-reviewed tumor foci for Gleason architectural subtype...
February 2, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28159491/the-role-of-magnetic-resonance-image-guided-prostate-biopsy-in-stratifying-men-for-risk-of-extracapsular-extension-at-radical-prostatectomy-raskolnikov-d-george-ak-rais-bahrami-s-turkbey-b-siddiqui-mm-shakir-na-okoro-c-rothwax-jt-walton-diaz-a-sankineni-s-su
#8
Eggener Scott
PURPOSE: Magnetic resonance imaging detects extracapsular extension by prostate cancer with excellent specificity but low sensitivity. This limits surgical planning, which could be modified to account for focal extracapsular extension with image directed guidance for wider excision. In this study, we evaluate the performance of multiparametric magnetic resonance imaging in extracapsular extension detection and determine which preoperative variables predict extracapsular extension on final pathology when multiparametric magnetic resonance imaging predicts organ confined disease...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28146062/high-level-%C3%AE-glutamyl-hydrolase-ggh-expression-is-linked-to-poor-prognosis-in-erg-negative-prostate-cancer
#9
Nathaniel Melling, Masoud Rashed, Cornelia Schroeder, Claudia Hube-Magg, Martina Kluth, Dagmar Lang, Ronald Simon, Christina Möller-Koop, Stefan Steurer, Guido Sauter, Frank Jacobsen, Franziska Büscheck, Corinna Wittmer, Till Clauditz, Till Krech, Maria Christina Tsourlakis, Sarah Minner, Hartwig Huland, Markus Graefen, Lars Budäus, Imke Thederan, Georg Salomon, Thorsten Schlomm, Waldemar Wilczak
γ-glutamyl-hydrolase (GGH) is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. Employing GGH immunohistochemistry on a tissue microarray with 12,427 prostate cancers, we found that GGH expression was negative to low in normal prostate epithelium, whereas 88.3% of our 10,562 interpretable cancers showed GGH expression. GGH staining was considered as low intensity in 49.6% and as high intensity in 38.6% of cancers. High GGH expression was linked to the TMPRSS2:ERG-fusion positive subset of cancers (p < 0...
January 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28140460/factors-predicting-prostate-cancer-upgrading-on-magnetic-resonance-imaging-targeted-biopsy-in-an-active-surveillance-population
#10
Win Shun Lai, Jennifer B Gordetsky, John V Thomas, Jeffrey W Nix, Soroush Rais-Bahrami
BACKGROUND: The objective of this study was to create a nomogram model integrating clinical and multiparametric magnetic resonance imaging (MP-MRI)-based variables to predict prostate cancer upgrading in a population of active surveillance (AS) patients. METHODS: Prostate cancer patients on AS who underwent MP-MRI with magnetic resonance imaging (MRI)/ultrasound (US) fusion-guided biopsy were identified. Clinical and imaging variables, including the prostate-specific antigen density (PSAD), number of lesions, total lesion volume, total lesion density, Prostate Imaging Reporting and Data System magnetic resonance imaging suspicion score (MRI-SS), and duration between prereferral systematic and MRI/US fusion-guided biopsy sessions, were assessed...
January 31, 2017: Cancer
https://www.readbyqxmd.com/read/28134577/primary-intraprostatic-synovial-sarcoma
#11
Andrea M Olofson, Konstantinos Linos
Primary intraprostatic synovial sarcoma is a rare presentation of an otherwise well-studied disease, and it is one of the few primary sarcomas to occur in the prostate. Ancillary diagnostic techniques including immunohistochemistry and molecular genetics are useful to establish a definitive diagnosis. Despite its unorthodox location, it shares histologic and molecular genetic characteristics with tumors found elsewhere in the body. Most notably, the chromosomal translocation t(X;18)(p11;q11) encodes a chimeric transcription-activating protein, SS18-SSX, which has been identified as the primary driver mutation...
February 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28126217/prostate-mr-imaging-an-update
#12
REVIEW
Hiram Shaish, Samir S Taneja, Andrew B Rosenkrantz
Improvements in prostate MR imaging techniques and the introduction of MR imaging-targeted biopsies have had central roles in prostate cancer (PCa) management. The role of MR imaging has progressed from largely staging patients with biopsy-proven PCa to detecting, characterizing, and guiding the biopsy of suspected PCa. These diagnostic advances, combined with improved therapeutic interventions, have led to a more sophisticated and individually tailored approach to patients' unique PCa profile. This review discusses the MR imaging, a standardized reporting scheme, and the role of fusion-targeted prostate biopsy...
March 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28123608/the-novel-pim1-inhibitor-nms-p645-reverses-pim1-dependent-effects-on-tmprss2-erg-positive-prostate-cancer-cells-and-shows-anti-proliferative-activity-in-combination-with-pi3k-inhibition
#13
Luca Mologni, Vera Magistroni, Francesco Casuscelli, Marisa Montemartini, Carlo Gambacorti-Passerini
PIM1 is over-expressed in multiple tumors, including prostate cancer (PCa). PIM1 upregulation is mediated by direct binding of the ERG transcription factor to its promoter. About 50% of PCa cases are characterized by the presence of the TMPRSS2/ERG fusion, leading to ERG over-expression and thus to PIM1 transcriptional activation. PIM kinases are considered as weak oncogenes, but when combined with additional genetic alterations can induce strong transforming effects. Here we show anti-proliferative activity of the newly described PIM1 inhibitor NMS-P645 in combination with the PI3K inhibitor GDC-0941 in TMPRSS2/ERG positive and negative PCa cells...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28116598/enterolactone-glucuronide-and-%C3%AE-glucuronidase-in-antibody-directed-enzyme-prodrug-therapy-for-targeted-prostate-cancer-cell-treatment
#14
Yunyun Di, Shaoping Ji, Philipp Wolf, Ed S Krol, Jane Alcorn
Evidence from preclinical and animal studies demonstrated an anticancer effect of flaxseed lignans, particularly enterolactone (ENL), against prostate cancer. However, extensive first-pass metabolism following oral lignan consumption results in their systemic availability primarily as glucuronic acid conjugates (ENL-Gluc) and their modest in vivo effects. To overcome the unfavorable pharmacokinetics and improve their effectiveness in prostate cancer, antibody-directed enzyme prodrug therapy (ADEPT) might offer a novel strategy to allow for restricted activation of ENL from circulating ENL-Gluc within the tumor environment...
January 23, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28115952/salvage-high-dose-rate-brachytherapy-for-histologically-confirmed-macroscopic-local-relapsed-prostate-cancer-after-radical-prostatectomy
#15
David Buchser, Alfonso Gomez-Iturriaga, J Ignacio Rodriguez Melcon, Francisco Casquero, Roberto Llarena, Jon Cacicedo, Pedro Bilbao
PURPOSE: To evaluate the feasibility of the use of real-time magnetic resonance imaging (MRI)-transrectal ultrasound (TRUS) fusion guided high-dose-rate brachytherapy (HDR-BT) +/- external beam radiation therapy (EBRT) in patients with histologically-proven local relapse after radical prostatectomy. MATERIAL AND METHODS: We retrospectively reviewed 13 patients treated with real-time MRI-TRUS fusion HDR-BT for a local relapse of prostate cancer after radical surgery...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28114882/fugeprior-a-novel-gene-fusion-prioritization-algorithm-based-on-accurate-fusion-structure-analysis-in-cancer-rna-seq-samples
#16
Giulia Paciello, Elisa Ficarra
BACKGROUND: Latest Next Generation Sequencing technologies opened the way to a novel era of genomic studies, allowing to gain novel insights into multifactorial pathologies as cancer. In particular gene fusion detection and comprehension have been deeply enhanced by these methods. However, state of the art algorithms for gene fusion identification are still challenging. Indeed, they identify huge amounts of poorly overlapping candidates and all the reported fusions should be considered for in lab validation clearly overwhelming wet lab capabilities...
January 23, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28111879/detection-of-prostate-cancer-using-magnetic-resonance-imaging-ultrasonography-fusion-targeted-biopsy-in-african-american-men
#17
Toshitaka Shin, Thomas B Smyth, Osamu Ukimura, Nariman Ahmadi, Andre Luis de Castro Abreu, Masakatsu Oishi, Hiromitsu Mimata, Inderbir S Gill
OBJECTIVE: To assess the diagnostic yield of targeted prostate biopsy in African-American (A-A) men using image fusion of multi-parametric magnetic resonance imaging (mp-MRI) with real-time trans-rectal ultrasonography (US). PATIENTS AND METHODS: We retrospectively analyzed 661 patients (117 A-A and 544 Caucasian) who underwent pre-biopsy mp-MRI and the following MRI/US fusion biopsy (UroStation, Koelis) (10/2012 - 8/2015). The mp-MRIs were reported on a 5-point Likert scale of suspicion...
January 23, 2017: BJU International
https://www.readbyqxmd.com/read/28102015/circulating-antioxidant-levels-and-risk-of-prostate-cancer-by-tmprss2-erg
#18
Rebecca E Graff, Gregory Judson, Thomas U Ahearn, Michelangelo Fiorentino, Massimo Loda, Edward L Giovannucci, Lorelei A Mucci, Andreas Pettersson
BACKGROUND: Few studies have considered etiological differences across molecular subtypes of prostate cancer, despite potential to improve opportunities for precision prevention of a disease for which modifiable risk factors have remained elusive. Factors that lead to DNA double-strand breaks, such as oxidative stress, may promote the formation of the TMPRSS2:ERG gene fusion in prostate cancer. We tested the hypothesis that increasing levels of pre-diagnostic circulating antioxidants, which may reduce oxidative stress, are associated with lower risk of developing TMPRSS2:ERG positive prostate cancer...
January 19, 2017: Prostate
https://www.readbyqxmd.com/read/28093292/multiparametric-magnetic-resonance-ultrasound-fusion-prostate-biopsy-number-and-spatial-distribution-of-cores-for-a-better-index-tumor-detection-and-characterization
#19
Francesco Porpiglia, Stefano De Luca, Roberto Passera, Agostino De Pascale, Daniele Amparore, Giovanni Cattaneo, Enrico Checcucci, Sabrina De Cillis, Diletta Garrou, Matteo Manfredi, Fabrizio Mele, Enrico Bollito, Cristian Fiori
PURPOSE: to evaluate the minimum cores number for a better index tumor detection, to investigate the best core site and biopsy Gleason Score (GS) heterogeneity within the same index lesion, to optimize the highest GS detection. MATERIALS AND METHODS: 327 patients with negative DRE underwent MRI/TRUS fusion targeted biopsy (TBx) for elevated/rising PSA, and/or ≥1 detectable lesions at multiparametric MRI after previous negative standard biopsy. Depending on the diameter of each index lesion, ≤8 or > 8 mm, four or six cores were taken respectively, according to a well-determined sequence...
January 13, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28093146/re-magnetic-resonance-imaging-ultrasound-fusion-biopsy-during-prostate-cancer-active-surveillance
#20
Samir S Taneja
No abstract text is available yet for this article.
February 2017: Journal of Urology
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