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https://www.readbyqxmd.com/read/28333017/effect-of-prostate-magnetic-resonance-imaging-ultrasound-fusion-guided-biopsy-on-radiation-treatment-recommendations
#1
Aaron Reed, Luca F Valle, Uma Shankavaram, Andra Krauze, Aradhana Kaushal, Erica Schott, Theresa Cooley-Zgela, Bradford Wood, Peter Pinto, Peter Choyke, Baris Turkbey, Deborah E Citrin
PURPOSE: Targeted magnetic resonance imaging (MRI)/ultrasound fusion prostate biopsy (MRI-Bx) has recently been compared with the standard of care extended sextant ultrasound-guided prostate biopsy (SOC-Bx), with the former associated with an increased rate of detection of clinically significant prostate cancer. The present study sought to determine the influence of MRI-Bx on radiation therapy and androgen deprivation therapy (ADT) recommendations. METHODS AND MATERIALS: All patients who had received radiation treatment and had undergone SOC-Bx and MRI-Bx at our institution were included...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28297298/dosimetric-and-volumetric-changes-in-the-rectum-and-bladder-in-patients-receiving-cbct-guided-prostate-imrt-analysis-based-on-daily-cbct-dose-calculation
#2
David Pearson, Sukhdeep K Gill, Nina Campbell, Krishna Reddy
Delivered dose can be calculated by transferring the planned treatment beams onto the daily CBCT. Bladder and rectum volumetric doses were calculated and correlated to the daily bladder and rectum fullness. Patients for this study underwent hypofractionated prostate IMRT to 70 Gy in 28 fractions. Daily CBCT was utilized for image guidance. A clinically acceptable plan was created using a CTV-to-PTV uniform margin of 5 mm. Image fusion was performed to transfer the bladder and rectum contours onto each CBCT...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28293250/expression-of-a-human-prostatic-acid-phosphatase-pap-igm-fc-fusion-protein-in-plants-using-in-vitro-tissue-subculture
#3
Yang J Kang, Deuk-Su Kim, Soon-Chul Myung, Kisung Ko
In this study, prostatic acid phosphatase (PAP), which is overexpressed in human prostate cancer cells, was cloned to be fused to the IgM constant fragment (Fc) for enhancing immunogenicity and expressed in transgenic tobacco plants. Then, the transgenic plants were propagated by in vitro tissue subculture. Gene insertion and expression of the recombinant PAP-IgM Fc fusion protein were confirmed in each tested the first, second, and third subculture generations (SG1, SG2, and SG3, respectively). Transcription levels were constantly maintained in the SG1, SG2, and SG3 leaf section (top, middle, and base)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28282546/overexpression-of-the-a-disintegrin-and-metalloproteinase-adam15-is-linked-to-a-small-but-highly-aggressive-subset-of-prostate-cancers
#4
Christoph Burdelski, Michael Fitzner, Claudia Hube-Magg, Martina Kluth, Asmus Heumann, Ronald Simon, Till Krech, Till Clauditz, Franziska Büscheck, Stefan Steurer, Corinna Wittmer, Andrea Hinsch, Andreas M Luebke, Frank Jacobsen, Sarah Minner, Maria Christina Tsourlakis, Burkhard Beyer, Thomas Steuber, Imke Thederan, Guido Sauter, Jakob Izbicki, Thorsten Schlomm, Waldemar Wilczak
The A Disintegrin and Metalloproteinase (ADAM) family of endopeptidases plays a role in many solid cancers and includes promising targets for anticancer therapies. Deregulation of ADAM15 has been linked to tumor aggressiveness and cell line studies suggest that ADAM15 overexpression may also be implicated in prostate cancer. To evaluate the impact of ADAM15 expression and its relationship with key genomic alterations, a tissue microarray containing 12,427 prostate cancers was analyzed by immunohistochemistry...
March 7, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28267899/-risk-stratification-based-on-magnetic-resonance-imaging-and-prostate-specific-antigen-density-may-reduce-unnecessary-follow-up-biopsy-procedures-in-men-on-active-surveillance-for-low-risk-prostate-cancer
#5
Arnout R Alberts, Monique J Roobol, Frank-Jan H Drost, Geert J van Leenders, Leonard P Bokhorst, Chris H Bangma, Ivo G Schoots
OBJECTIVES: To assess the value of risk-stratification based on magnetic resonance imaging (MRI) and prostate-specific antigen (PSA) density in reducing unnecessary biopsies without missing Gleason pattern 4 prostate cancer (PCa) in men on active surveillance. MATERIALS AND METHODS: A total of 210 men on active surveillance with GS 3+3 PCa received a first MRI and if indicated (PI-RADS ≥3) targeted biopsy (TBx) using MRI-TRUS fusion. The MRI was performed 3 months after diagnosis (group A: n=97), at confirmatory biopsy (group B: n=39) or at surveillance biopsy after ≥1 repeat TRUS-guided systematic biopsies (TRUS-Bx) (group C: n=74)...
March 7, 2017: BJU International
https://www.readbyqxmd.com/read/28256901/diagnosis-of-typical-and-atypical-transitional-zone-prostate-cancer-and-its-mimics-at-multiparametric-prostate-mri
#6
Jinxing Yu, Ann S Fulcher, Sarah G Winks, Mary A Turner, Ryan D Clayton, Michael Brooks, Sean Li
Many of the current clinical screening methods for prostate cancer (PCa) such as prostate specific antigen (PSA) testing or trans-rectal ultrasound (TRUS)-guided prostate biopsy lack sensitivity and specificity for diagnosis of PCa of the transition zone (TZ). Recent technical advances in multiparametric-MRI (mp-MRI) have markedly improved detection of PCa of the TZ. However, there are many diagnostic challenges we still encounter in our daily practice that compromise the accuracy of the diagnosis. By performing both MRI-guided and US/MRI fusion-guided biopsies, we have gained extensive experience in the diagnosis of PCa of the TZ...
March 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28245430/man2a1-fer-fusion-gene-is-expressed-by-human-liver-and-other-tumor-types-and-has-oncogenic-activity-in-mice
#7
Zhang-Hui Chen, Yan P Yu, Junyan Tao, Silvia Liu, George Tseng, Michael Nalesnik, Ronald Hamilton, Rohit Bhargava, Joel B Nelson, Arjun Pennathur, Satdarshan P Monga, James D Luketich, George K Michalopoulos, Jian-Hua Luo
BACKGROUND & AIMS: Human tumors and liver cancer cell lines express the product of a fusion between the first 13 exons in the mannosidase α class 2A member 1 gene (MAN2A1) and the last 6 exons in the FER tyrosine kinase gene (FER), called MAN2A1-FER. We investigated whether MAN2A1-FER is expressed by human liver tumors and its role in liver carcinogenesis. METHODS: We performed reverse transcription polymerase chain reaction analyses of 102 non-small cell lung tumors, 61 ovarian tumors, 70 liver tumors, 156 glioblastoma multiform samples, 27 esophageal adenocarcinomas, and 269 prostate cancer samples, as well as 10 nontumor liver tissues and 20 nontumor prostate tissues, collected at the University of Pittsburgh...
February 25, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28238758/pathological-findings-in-multiparametric-magnetic-resonance-imaging-ultrasound-fusion-guided-biopsy-relation-to-prostate-cancer-focal-therapy
#8
REVIEW
Jennifer Gordetsky, Soroush Rais-Bahrami, Jonathan I Epstein
The introduction of widespread prostate-specific antigen screening brought about an increase in the detection of clinically low-risk prostate cancer. Many of these patients are overtreated by radical prostatectomy and radiation. Comparatively, focal therapy for prostate cancer offers the advantage of decreased rates of incontinence and impotence. The 12-core extended sextant transrectal ultrasound-guided needle biopsy is unable to safely identify candidates for focal therapy. Multiparametric magnetic resonance imaging (MRI) and MRI/ultrasound fusion-guided biopsy can detect more clinically significant prostate cancers and aid in accurate detection of higher-grade disease...
February 24, 2017: Urology
https://www.readbyqxmd.com/read/28238033/clinical-and-multiparametric-mri-signatures-of-granulomatous-prostatitis
#9
Soroush Rais-Bahrami, Jeffrey W Nix, Baris Turkbey, Jason A Pietryga, Rupan Sanyal, John V Thomas, Jennifer B Gordetsky
PURPOSE: The purpose of the study is to differentiate granulomatous prostatitis (GP) from high-grade prostate cancer (PCa) based on clinical findings and imaging characteristics on multiparametric MRI (MP-MRI). METHODS: Pathology from patients undergoing MRI/US fusion-guided prostate biopsies between 2014 and 2015 was reviewed. Five patients with biopsy proven GP were identified as well as 15 patients with biopsy-proven Gleason score ≥4 + 3 = 7 PCa. Patients were matched for age, serum PSA level, and prebiopsy-assigned MP-MRI cancer suspicion scores...
February 25, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28225639/cost-effectiveness-comparison-of-imaging-guided-prostate-biopsy-techniques-systematic-transrectal-ultrasound-direct-in-bore-mri-and-image-fusion
#10
Wulphert Venderink, Tim M Govers, Maarten de Rooij, Jurgen J Fütterer, J P Michiel Sedelaar
OBJECTIVE: Three commonly used prostate biopsy approaches are systematic transrectal ultrasound guided, direct in-bore MRI guided, and image fusion guided. The aim of this study was to calculate which strategy is most cost-effective. MATERIALS AND METHODS: A decision tree and Markov model were developed to compare cost-effectiveness. Literature review and expert opinion were used as input. A strategy was deemed cost-effective if the costs of gaining one quality-adjusted life year (incremental cost-effectiveness ratio) did not exceed the willingness-to-pay threshold of €80,000 (≈$85,000 in January 2017)...
February 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28222486/accuracy-of-real-time-magnetic-resonance-imaging-transrectal-ultrasound-fusion-image-guided-transperineal-target-biopsy-with-needle-tracking-with-a-mechanical-position-encoded-stepper-in-detecting-significant-prostate-cancer-in-biopsy-na%C3%A3-ve-men
#11
Sunao Shoji, Shinichiro Hiraiwa, Takahiro Ogawa, Masayoshi Kawakami, Mayura Nakano, Kazunobu Hashida, Yoshinobu Sato, Terumitsu Hasebe, Toyoaki Uchida, Takuma Tajiri
OBJECTIVE: To evaluate the accuracy of real-time elastic fusion image-guided transperineal prostate biopsy with needle tracking involving a mechanical position-encoded stepper in detecting clinically significant prostate cancer for biopsy-naïve men. METHODS: We prospectively recruited patients with serum prostate-specific antigen levels of 4.0-20 ng/mL and suspicious of prostate cancer on multiparametric magnetic resonance imaging. They underwent targeted biopsies for cancer-suspicious lesions and 12-core systematic biopsies...
February 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28220802/the-prostate-cancer-prevention-trial-risk-calculator-2-0-performs-equally-for-standard-biopsy-and-mri-us-fusion-guided-biopsy
#12
M Maruf, M Fascelli, A K George, M M Siddiqui, M Kongnyuy, J M DiBianco, A Muthigi, S Valayil, A Sidana, T P Frye, A Kilchevsky, P L Choyke, B Turkbey, B J Wood, P A Pinto
BACKGROUND: The Prostate Cancer Prevention Trial Risk Calculator 2.0 (PCPTRC) is a widely used risk-based calculator used to assess a man's risk of prostate cancer (PCa) before biopsy. This risk calculator was created from data of a patient cohort undergoing a 6-core sextant biopsy, and subsequently validated in men undergoing 12-core systematic biopsy (SBx). The accuracy of the PCPTRC has not been studied in patients undergoing magnetic resonance imaging/ultrasound (MRI/US) fusion-guided biopsy (FBx)...
February 21, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28216939/prostatic-intraepithelial-neoplasia-like-ductal-prostatic-adenocarcinoma-a-case-suitable-for-active-surveillance
#13
Soroush Rais-Bahrami, Melissa R Dillard, Grace G Zhu, Jennifer B Gordetsky
In contrast to typical prostatic ductal adenocarcinoma, prostatic intraepithelial neoplasia (PIN)-like ductal adenocarcinoma is a rare variant of prostate cancer with low-grade clinical behavior. We report a case of a 66-year-old African-American male with an elevated serum prostate-specific antigen who underwent multiparametric prostate magnetic resonance imaging (MRI) and MRI/ultrasound fusion-guided biopsies. Pathology demonstrated low-volume Gleason score 3 + 3 = 6 (Grade Group 1), acinar adenocarcinoma involving one core and PIN-like ductal adenocarcinoma on a separate core...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28216280/tmprss2-erg-fusion-in-an-uncommon-presentation-of-prostate-cancer
#14
Nabil Adra, Liang Cheng, Nasser H Hanna, Greg Durm
No abstract text is available yet for this article.
February 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28193277/anti-tumor-effects-of-a-recombinant-anti-prostate-specific-membrane-antigen-immunotoxin-against-prostate-cancer-cells
#15
Ping Meng, Qing-Chuan Dong, Guang-Guo Tan, Wei-Hong Wen, He Wang, Geng Zhang, Yan-Zhu Wang, Yu-Ming Jing, Chen Wang, Wei-Jun Qin, Jian-Lin Yuan
BACKGROUND: To evaluate anti-prostate cancer effects of a chimeric tumor-targeted killer protein. METHODS: We established a novel fusion gene, immunocasp-3, composed of NH2-terminal leader sequence fused with an anti-prostate-specific membrane antigen (PSMA) antibody (J591), the furin cleavage sequences of diphtheria toxin (Fdt), and the reverse coding sequences of the large and small subunits of caspase-3 (revcaspase-3). The expressing level of the immunocasp-3 gene was evaluated by using the reverse transcription-PCR (RT-PCR) and western blot analysis...
February 13, 2017: BMC Urology
https://www.readbyqxmd.com/read/28179286/italian-prostate-biopsies-group-2016-updated-guidelines-insights
#16
REVIEW
Andrea Fandella, Vincenzo Scattoni, Andrea Galosi, Pietro Pepe, Michelangelo Fiorentino, Caterina Gaudiano, Marco Giampaoli, Roberta Gunelli, Pasquale Martino, Vittorino Montanaro, Rodolfo Montironi, Tiziana Pierangeli, Armando Stabile, Alessandro Bertaccini
AIM: To present a summary of the updated guidelines of the Italian Prostate Biopsies Group following the best recent evidence of the literature. MATERIALS AND METHODS: A systematic review of the new data emerging from 2012-2015 was performed by a panel of 14 selected Italian experts in urology, pathology and radiology. The experts collected articles published in the English-language literature by performing a search using Medline, EMBASE and the Cochrane Library database...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28163032/impact-of-gleason-subtype-on-prostate-cancer-detection-using-multiparametric-mri-correlation-with-final-histopathology
#17
Matthew Truong, Gary Hollenberg, Eric Weinberg, Edward M Messing, Hiroshi Miyamoto, Thomas P Frye
PURPOSE: Our purpose was to determine whether Gleason pattern 4 architecture impacts tumor visibility on multiparametric (mpMRI) and correlate with final histopathology. MATERIALS AND METHODS: A total of 83 tumor foci were identified within 22 radical prostatectomy specimens from patients with a prior negative biopsy who underwent MR/US fusion biopsy followed by radical prostatectomy from January 2015-July 2016. A genitourinary pathologist re-reviewed tumor foci for Gleason architectural subtype...
February 2, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28159491/the-role-of-magnetic-resonance-image-guided-prostate-biopsy-in-stratifying-men-for-risk-of-extracapsular-extension-at-radical-prostatectomy-raskolnikov-d-george-ak-rais-bahrami-s-turkbey-b-siddiqui-mm-shakir-na-okoro-c-rothwax-jt-walton-diaz-a-sankineni-s-su
#18
Eggener Scott
PURPOSE: Magnetic resonance imaging detects extracapsular extension by prostate cancer with excellent specificity but low sensitivity. This limits surgical planning, which could be modified to account for focal extracapsular extension with image directed guidance for wider excision. In this study, we evaluate the performance of multiparametric magnetic resonance imaging in extracapsular extension detection and determine which preoperative variables predict extracapsular extension on final pathology when multiparametric magnetic resonance imaging predicts organ confined disease...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28146062/high-level-%C3%AE-glutamyl-hydrolase-ggh-expression-is-linked-to-poor-prognosis-in-erg-negative-prostate-cancer
#19
Nathaniel Melling, Masoud Rashed, Cornelia Schroeder, Claudia Hube-Magg, Martina Kluth, Dagmar Lang, Ronald Simon, Christina Möller-Koop, Stefan Steurer, Guido Sauter, Frank Jacobsen, Franziska Büscheck, Corinna Wittmer, Till Clauditz, Till Krech, Maria Christina Tsourlakis, Sarah Minner, Hartwig Huland, Markus Graefen, Lars Budäus, Imke Thederan, Georg Salomon, Thorsten Schlomm, Waldemar Wilczak
γ-glutamyl-hydrolase (GGH) is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. Employing GGH immunohistochemistry on a tissue microarray with 12,427 prostate cancers, we found that GGH expression was negative to low in normal prostate epithelium, whereas 88.3% of our 10,562 interpretable cancers showed GGH expression. GGH staining was considered as low intensity in 49.6% and as high intensity in 38.6% of cancers. High GGH expression was linked to the TMPRSS2:ERG-fusion positive subset of cancers (p < 0...
January 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28140460/factors-predicting-prostate-cancer-upgrading-on-magnetic-resonance-imaging-targeted-biopsy-in-an-active-surveillance-population
#20
Win Shun Lai, Jennifer B Gordetsky, John V Thomas, Jeffrey W Nix, Soroush Rais-Bahrami
BACKGROUND: The objective of this study was to create a nomogram model integrating clinical and multiparametric magnetic resonance imaging (MP-MRI)-based variables to predict prostate cancer upgrading in a population of active surveillance (AS) patients. METHODS: Prostate cancer patients on AS who underwent MP-MRI with magnetic resonance imaging (MRI)/ultrasound (US) fusion-guided biopsy were identified. Clinical and imaging variables, including the prostate-specific antigen density (PSAD), number of lesions, total lesion volume, total lesion density, Prostate Imaging Reporting and Data System magnetic resonance imaging suspicion score (MRI-SS), and duration between prereferral systematic and MRI/US fusion-guided biopsy sessions, were assessed...
January 31, 2017: Cancer
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