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Fusion prostate

Philipp Maletzki, Christoph Schwab, Patrick Markart, Daniel Engeler, Johann Schiefer, Ludwig Plasswilm, Hans-Peter Schmid
Background: Seed migration is a common finding after low dose rate brachytherapy of the prostate. It has often been assessed soon after implantation, but little is known about late seed migration. We evaluated the incidence, site, symptoms, and therapeutic consequences of late seed migration more than 3 years postoperatively. Materials and methods: We retrospectively examined the data of 63 unselected patients with transrectal ultrasound-guided, transperineal low dose rate brachytherapy of the prostate with stranded seeds between 2001 and 2010...
June 2018: Prostate International
Yi-Mi Wu, Marcin Cieślik, Robert J Lonigro, Pankaj Vats, Melissa A Reimers, Xuhong Cao, Yu Ning, Lisha Wang, Lakshmi P Kunju, Navonil de Sarkar, Elisabeth I Heath, Jonathan Chou, Felix Y Feng, Peter S Nelson, Johann S de Bono, Weiping Zou, Bruce Montgomery, Ajjai Alva, Dan R Robinson, Arul M Chinnaiyan
Using integrative genomic analysis of 360 metastatic castration-resistant prostate cancer (mCRPC) samples, we identified a novel subtype of prostate cancer typified by biallelic loss of CDK12 that is mutually exclusive with tumors driven by DNA repair deficiency, ETS fusions, and SPOP mutations. CDK12 loss is enriched in mCRPC relative to clinically localized disease and characterized by focal tandem duplications (FTDs) that lead to increased gene fusions and marked differential gene expression. FTDs associated with CDK12 loss result in highly recurrent gains at loci of genes involved in the cell cycle and DNA replication...
June 14, 2018: Cell
Maria Gosein, Emily Pang, Silvia Chang, Peter Black, Larry Goldenberg, Alison Harris, Jason Yasenjiang, Masoud Yousefi
No abstract text is available yet for this article.
June 9, 2018: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
M H Choi, Y J Lee, S E Jung, S E Rha, J Y Byun
AIM: To validate the diagnostic accuracy of Prostate Imaging-Reporting and Data System (PI-RADS) version 2 in detecting clinically significant prostate cancer (csPCa, Gleason score ≥7) on prebiopsy biparametric MRI (bpMRI) in patients with different prostate-specific antigen (PSA) levels. MATERIALS AND METHODS: This retrospective study included 184 patients who underwent prebiopsy bpMRI followed by transrectal ultrasonography-guided biopsy between June 2015 and February 2017...
June 9, 2018: Clinical Radiology
Shalini S Yadav, Jennifer A Stockert, Victoria Hackert, Kamlesh K Yadav, Ashutosh K Tewari
Prostate cancer (PCa) has long been thought of as a disease with a heterogeneous phenotype. It can manifest in men as benign growths that can be safely watched or as more aggressive malignancies that can prove fatal. Recent investigations at the genomic, histopathological and molecular levels have identified tumor heterogeneity, the phenomenon of individual tumor cells presenting distinct genomic and phenotypic characteristics, as one of the most confounding and complex factors underlying PCa diagnosis, prognosis, and treatment...
June 7, 2018: Urologic Oncology
Xiaosong Meng, Andrew B Rosenkrantz, Richard Huang, Fang Ming Deng, James S Wysock, Marc Bjurlin, William C Huang, Herbert Lepor, Samir S Taneja
PURPOSE: While MRI-Ultrasound Fusion-targeted biopsy (MRF-TB) allows for improved detection of clinically significant prostate cancer (csPCa), concerning numbers of clinically significant disease are still missed. We hypothesize that a number of these are due to the learning curve associated with MRF-TB. We report results of repeat MRF-TB in men with continued suspicion for cancer and the institutional learning curve in detection of csPCa over time. MATERIALS AND METHODS: Analysis of 1813 prostate biopsies in a prospectively acquired cohort of men presenting for prostate biopsy over a 4-year period...
June 7, 2018: Journal of Urology
Andreas Maxeiner, Thomas Fischer, Julia Schwabe, Alexander Daniel Jacques Baur, Carsten Stephan, Robert Peters, Torsten Slowinski, Maximilian von Laffert, Stephan Rodrigo Marticorena Garcia, Bernd Hamm, Ernst-Michael Jung
PURPOSE:  The aim of this study was to investigate contrast-enhanced ultrasound (CEUS) parameters acquired by software during magnetic resonance imaging (MRI) US fusion-guided biopsy for prostate cancer (PCa) detection and discrimination. MATERIALS AND METHODS:  From 2012 to 2015, 158 out of 165 men with suspicion for PCa and with at least 1 negative biopsy of the prostate were included and underwent a multi-parametric 3 Tesla MRI and an MRI/US fusion-guided biopsy, consecutively...
June 6, 2018: Ultraschall in der Medizin
David A Woodrum, Krzysztof R Gorny, Lance A Mynderse
Prostate cancer is the most commonly diagnosed noncutaneous cancer and second leading cause of death in men. Many patients with clinically organ-confined prostate cancer undergo definitive treatment of the whole gland, including radical prostatectomy, radiation therapy, and cryosurgery. Active surveillance is a growing alternative option for patients with documented low-volume and low-grade prostate cancer. However, many patients are wanting a less morbid focal treatment alternative. With recent advances in software and hardware of magnetic resonance imaging (MRI), multiparametric MRI of the prostate has been shown to improve the accuracy in detecting and characterizing clinically significant prostate cancer...
June 2018: Topics in Magnetic Resonance Imaging: TMRI
Tan B Nguyen, Alexander Ushinsky, Albert Yang, Michael Nguyentat, Sara Fardin, Edward Uchio, Chandana Lall, Thomas Lee, Roozbeh Houshyar
OBJECTIVE: The aim of this study is to evaluate the utility of quantitative apparent diffusion coefficient (ADC) measurements and normalized ADC ratios in multiparametric MRI for the diagnosis of clinically significant peripheral zone (PZ) prostate cancer particularly among equivocally suspicious prostate lesions. METHODS: A retrospective analysis of 95 patients with PZ lesions by PI-RADSv2 criteria, and who underwent subsequent MRI-US fusion biopsy, was approved by an institutional review board...
June 5, 2018: British Journal of Radiology
Kay M Westenfelder, Beatrice Lentes, Julia Rackerseder, Nassir Navab, Jürgen E Gschwend, Matthias Eiber, Tobias Maurer
No abstract text is available yet for this article.
May 29, 2018: Clinical Genitourinary Cancer
Kareem N Rayn, Jonathan B Bloom, Samuel A Gold, Graham R Hale, Joseph A Baiocco, Sherif Mehralivand, Marcin Czarniecki, Vikram K Sabarwal, Vladimir Valera, Bradford J Wood, Maria J Merino, Peter Choyke, Baris Turkbey, Peter A Pinto
PURPOSE: We examined the additional value of preoperative prostate multiparametric magnetic resonance imaging (mpMRI) and transrectal ultrasound/mpMRI fusion-guided targeted biopsy (Tbx) when used in combination with clinical nomograms in predicting adverse pathology at radical prostatectomy. MATERIALS AND METHODS: We identified all patients who underwent 3-Tesla mpMRI prior to fusion biopsy and radical prostatectomy (RP). The Partin and Memorial Sloan Kettering Cancer Center (MSKCC) pre-radical prostatectomy nomograms were used to estimate the probability of organ confined disease (OCD), extraprostatic extension (EPE), seminal vesicle invasion (SVI) and lymph node involvement (LNI) using both transrectal ultrasound-guided systematic biopsy (Sbx) and Tbx Gleason scores...
May 28, 2018: Journal of Urology
Marina Gomzikova, Sevindzh Kletukhina, Sirina Kurbangaleeva, Albert Rizvanov
Extracellular vesicles (EV) represent a promising vector system for biomolecules and drug delivery due to their natural origin and participation in intercellular communication. As the quantity of EVs is limited, it was proposed to induce the release of membrane vesicles from the surface of human cells by treatment with cytochalasin B. Cytochalasin B-induced membrane vesicles (CIMVs) were successfully tested as a vector for delivery of dye, nanoparticles, and a chemotherapeutic. However, it remained unclear whether CIMVs possess fusion specificity with target cells and thus might be used for more targeted delivery of therapeutics...
2018: BioMed Research International
Guila Delouya, Jean-Francois Carrier, Renée Xavier-Larouche, Yannick Hervieux, Dominic Béliveau-Nadeau, David Donath, Daniel Taussky
Purpose To compare the impact of the fusion of intraoperative transrectal ultrasound (TRUS) images with day 30 computed tomography (CT) and magnetic resonance imaging (MRI) on prostate volume and dosimetry. Methods and materials Seventy-five consecutive patients with CT and MRI obtained on day 30 with a Fast Spin Echo T2-weighted magnetic resonance (MR) sequence were analyzed. A rigid manual registration was performed between the intraoperative TRUS and day-30 CT based on the prostate volume. A second manual rigid registration was performed between the intraoperative TRUS and the day-30 MRI...
March 29, 2018: Curēus
Nicolai Hübner, Shahrokh Shariat, Mesut Remzi
PURPOSE OF REVIEW: To summarize the highest level evidence that was acquired within the last years, with regard to diagnosis of prostate cancer. With many secondary diagnostic tools becoming available, and not being mentioned in the guidelines, this review is meant to assist clinical decision-making in initial biopsy and rebiopsy settings. RECENT FINDINGS: The PROMIS Trial delivered level 1b evidence about the diagnostic accuracy of prostate multiparametric MRI (mpMRI) as a triage tool for prostate biopsy...
July 2018: Current Opinion in Urology
Xavier Filella, Esther Fernández-Galan, Rosa Fernández Bonifacio, Laura Foj
Prostate cancer (PCa) is the second most common cancer in men worldwide. A large proportion of PCa are latent, never destined to progress or affect the patients' life. It is of utmost importance to identify which PCa are destined to progress and which would benefit from an early radical treatment. Prostate-specific antigen (PSA) remains the most used test to detect PCa. Its limited specificity and an elevated rate of overdiagnosis are the main problems associated with PSA testing. New PCa biomarkers have been proposed to improve the accuracy of PSA in the management of early PCa...
2018: Pharmacogenomics and Personalized Medicine
Alexandra M Blee, Yundong He, Yinhui Yang, Zhenqing Ye, Yuqian Yan, Yunqian Pan, Tao Ma, Joseph A Dugdale, Emily Kuehn, Manish Kohli, Rafael E Jimenez, Yu Chen, Wanhai Xu, Liguo Wang, Haojie Huang
PURPOSE: Deletions or mutations in PTEN and TP53 tumor suppressor genes have been linked to lineage plasticity in therapy-resistant prostate cancer. Fusion-driven overexpression of the oncogenic transcription factor ERG is observed in approximately 50% of all prostate cancers, many of which also harbor PTEN and TP53 alterations. However, the role of ERG in lineage plasticity of PTEN / TP53 -altered tumors is unclear. Understanding the collective effect of multiple mutations within one tumor is essential to combat plasticity-driven therapy resistance...
May 29, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Marc A Bjurlin, Audrey Renson, Soroush Rais-Bahrami, Matthew Truong, Andrew B Rosenkrantz, Richard Huang, Samir S Taneja
BACKGROUND: Magnetic resonance imaging (MRI) of the prostate after a prior negative biopsy may reduce the need for unnecessary repeat biopsies. OBJECTIVE: To externally validate a previously developed nomogram predicting benign prostate pathology on MRI/ultrasound (US) fusion-targeted biopsy in men with a Prostate Imaging Reporting and Data System (PI-RADS) 3-5 region of interest and a prior negative 12-core systematic biopsy, and update this nomogram to improve its performance...
May 22, 2018: European Urology Focus
Hubert Pakula, Douglas E Linn, Daniel R Schmidt, Marit Van Gorsel, Matthew G Vander Heiden, Zhe Li
TMPRSS2/ERG is the most common type of gene fusions found in human prostate cancer. There are two important features of TMPRSS2/ERG fusions. One is that these gene fusions lead to ectopic expression of ERG, an ETS family transcription factor, in prostate epithelial cells from the 5' control region of an androgen/estrogen dual-responsive gene, TMPRSS2; the other is that ~60% of these fusions are generated via intrachromosomal deletion of the interstitial region between TMPRSS2 and ERG. To recapitulate these important aspects of TMPRSS2/ERG fusions, we generated several TMPRSS2/ERG knockin mouse models based on the endogenous Tmprss2 locus...
2018: Methods in Molecular Biology
Samuel A Gold, Graham R Hale, Jonathan B Bloom, Clayton P Smith, Kareem N Rayn, Vladimir Valera, Bradford J Wood, Peter L Choyke, Baris Turkbey, Peter A Pinto
INTRODUCTION: Multiparametric magnetic resonance imaging (mpMRI) has improved clinicians' ability to detect clinically significant prostate cancer (csPCa). Combining or fusing these images with the real-time imaging of transrectal ultrasound (TRUS) allows urologists to better sample lesions with a targeted biopsy (Tbx) leading to the detection of greater rates of csPCa and decreased rates of low-risk PCa. In this review, we evaluate the technical aspects of the mpMRI-guided Tbx procedure to identify possible sources of error and provide clinical context to a negative Tbx...
May 21, 2018: World Journal of Urology
Maria C Velasquez, Paul J Taylor Smith, Nachiketh Soodana Prakash, Bruce Kava, Oleksandr N Kryvenko, Rosa Castillo-Acosta, Leonardo Kayat Bittencourt, Mark L Gonzalgo, Chad Ritch, Dipen J Parekh, Sanoj Punnen
No abstract text is available yet for this article.
May 2018: Urology Case Reports
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