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Kirema Garcia-Reyes, Hao G Nguyen, Ronald J Zagoria, Katsuto Shinohara, Peter R Carroll, Spencer C Behr, Antonio C Westphalen
PURPOSE: The purpose of this study was to estimate the impact of lesion visibility with transrectal ultrasound on the prediction of clinically significant prostate cancer with transrectal ultrasound-magnetic resonance imaging fusion biopsy. MATERIALS AND METHODS: This HIPAA (Health Insurance Portability and Accountability Act) compliant, institutional review board approved, retrospective study was performed in 178 men who were 64.7 years old with prostate specific antigen 8...
September 20, 2017: Journal of Urology
M Petronek, A Purysko, S Balik, J Ciezki, E Klein, D Wilkinson
PURPOSE: Transrectal Ultrasound (TRUS) imaging is utilized intra-operatively for LDR permanent prostate seed implant treatment planning. Prostate contouring with TRUS can be challenging at the apex and base. This study attempts to improve accuracy of prostate contouring with MRI-TRUS fusion to prevent over- or under-estimation of the prostate volume. METHODS: 14 patients with previous MRI guided prostate biopsy and undergone an LDR permanent prostate seed implant have been selected...
June 2016: Medical Physics
Andrew B Rosenkrantz, Sadhna Verma, Peter Choyke, Steven C Eberhardt, Scott E Eggener, Krishnanath Gaitonde, Masoom A Haider, Daniel J Margolis, Leonard S Marks, Peter Pinto, Geoffrey A Sonn, Samir S Taneja
PURPOSE: After an initial negative biopsy there is an ongoing need for strategies to improve patient selection for repeat biopsy as well as the diagnostic yield from repeat biopsies. MATERIALS AND METHODS: As a collaborative initiative of the AUA (American Urological Association) and SAR (Society of Abdominal Radiology) Prostate Cancer Disease Focused Panel, an expert panel of urologists and radiologists conducted a literature review and formed consensus statements regarding the role of prostate magnetic resonance imaging and magnetic resonance imaging targeted biopsy in patients with a negative biopsy, which are summarized in this review...
June 16, 2016: Journal of Urology
Arnaldo Mayer, Adi Zholkover, Orith Portnoy, Gil Raviv, Eli Konen, Zvi Symon
PURPOSE: Focal therapy in low-risk prostate cancer may provide the best balance between cancer control and quality of life preservation. As a minimally invasive approach performed under TRUS guidance, brachytherapy is an appealing framework for focal therapy. However, the contrast in TRUS images is generally insufficient to distinguish the target lesion from normal prostate tissue. MRI usually offers a much better contrast between the lesion and surrounding tissues. Registration between TRUS and MRI may therefore significantly improve lesion targeting capability in focal prostate brachytherapy...
June 2016: International Journal of Computer Assisted Radiology and Surgery
Vicki Nisenblat, Patrick M M Bossuyt, Cindy Farquhar, Neil Johnson, M Louise Hull
BACKGROUND: About 10% of women of reproductive age suffer from endometriosis. Endometriosis is a costly chronic disease that causes pelvic pain and subfertility. Laparoscopy, the gold standard diagnostic test for endometriosis, is expensive and carries surgical risks. Currently, no non-invasive tests that can be used to accurately diagnose endometriosis are available in clinical practice. This is the first review of diagnostic test accuracy of imaging tests for endometriosis that uses Cochrane methods to provide an update on the rapidly expanding literature in this field...
February 26, 2016: Cochrane Database of Systematic Reviews
Hannes Cash, Karsten Günzel, Andreas Maxeiner, Carsten Stephan, Thomas Fischer, Tahir Durmus, Kurt Miller, Patrick Asbach, Matthias Haas, Carsten Kempkensteffen
OBJECTIVE: To examine the value of additional transrectal ultrasonography (TRUS)-guided random biopsy (RB) in patients with negative magnetic resonance imaging (MRI)/ultrasonography (US) fusion-guided targeted biopsy (TB) and to identify possible reasons for TB failure. PATIENTS AND METHODS: We conducted a subgroup analysis of 61 men with prostate cancer (PCa) detected by 10-core RB but with a negative TB, from a cohort of 408 men with suspicious multiparametric magnetic resonance imaging (mpMRI) between January 2012 and January 2015...
July 2016: BJU International
Massimo Valerio, Sarah Willis, Jan van der Meulen, Mark Emberton, Hashim U Ahmed
PURPOSE OF REVIEW: An imaging-based pathway, including multiparametric MRI (mpMRI) and magnetic resonance (MR) targeted biopsy, is being increasingly proposed to overcome the shortcomings of the current pathway, based on transrectal ultrasound (TRUS) random biopsy. The purpose of this review is to look at the methodological considerations that need to be addressed prior to widespread adoption of this pathway. RECENT FINDINGS: Novel diagnostic tests should be evaluated in a stepwise fashion with respect to key points: technical accuracy, place in the clinical pathway, diagnostic accuracy, impact on patient outcome and cost-effectiveness...
November 2015: Current Opinion in Urology
Seyed Reza Mousavi, Haisu Wang, Seyyed Mohammad Hesabgar, Timothy J Scholl, Abbas Samani
PURPOSE: Association between tissue stiffness alteration and pathology is well known. This has formed the basis for prostate elastography imaging techniques where images of prostate tissue mechanical properties are reconstructed. In this paper, the authors present a novel prostate elastography technique which, unlike other techniques, relies on magnitude image data only. METHODS: This proposed technique works in conjunction with ultrasound or magnetic resonance imaging (MRI) imaging modalities and it requires the prostate's pre- and postdeformation images as input...
September 2015: Medical Physics
Bong-Hyeon Kye, Hyung-Jin Kim, Gun Kim, Jun-Gi Kim, Hyeon-Min Cho
PURPOSE: Restaging after neoadjuvant treatment is done for planning the surgical approach and, increasingly, to determine whether additional therapy or resection can be avoided for selected patients. MATERIALS AND METHODS: Local restaging after neoadjuvant chemoradiation therapy (nCRT) was performed in 270 patients with locally advanced (cT3or4 or N+) rectal cancer. Abdomen and pelvic computed tomography (APCT) was used in all 270 patients, transrectal ultrasound (TRUS) in 121 patients, and rectal magnetic resonance imaging (MRI) in 65 patients...
April 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Seyfettin Ciftci, Hasan Yilmaz, Esra Ciftci, Emrah Simsek, Murat Ustuner, Ufuk Yavuz, Bahar Muezzinoglu, Ozdal Dillioglugil
BACKGROUND: We aimed to evaluate the relationship between perineural invasion (PNI) and bone metastasis in prostate cancer (PCa). METHODS: We retrospectively reviewed the data of 633 PCas who had whole-body bone scan (WBBS) between 2008 and 2014. We recorded the age, clinical T-stage, total PSA (tPSA) prior to biopsy, Gleason sum (GS), and PNI in transrectal ultrasound guided biopsy (TRUS-Bx) and digital rectal examination findings. Bone metastases were assessed with WBBS and magnetic resonance image if WBBS was suspicious...
November 2015: Prostate
Elke Hauth, Horst Hohmuth, Corina Cozub-Poetica, Stefan Bernand, Meinrad Beer, Horst Jaeger
OBJECTIVE: Multiparametric MRI (mp-MRI) of the prostate is increasingly being used for local staging and detection of recurrence of prostate cancer (PCA). In patients with elevated prostate-specific antigen (PSA), mp-MRI could provide information on the position of the cancer, allowing adjustments to be made to the needle depth and direction before repeat transrectal ultrasound (TRUS)-guided biopsy to ensure accurate sampling of lesions. The purpose of the prospective study was to evaluate mp-MRI of the prostate in patients with PSA elevation before initial TRUS-guided biopsy...
October 2015: British Journal of Radiology
Paola Mapelli, Maria Picchio
An early and correct diagnosis together with accurate staging of prostate cancer is necessary in order to plan the most appropriate treatment strategy. Morphological imaging modalities such as transrectal ultrasonography (TRUS), CT, and MRI can have some limitations regarding their accuracy for primary diagnosis and staging of prostate cancer; for instance, they have limited specificity in differentiating cancer from benign prostatic conditions and, by using size as the only criterion to characterize lymph node metastases, they might not be accurate enough for tumour characterization...
September 2015: Nature Reviews. Urology
Berrend G Muller, Aradhana Kaushal, Sandeep Sankineni, Elena Lita, Anthony N Hoang, Arvin K George, Soroush Rais-Bahrami, Jochen Kruecker, Pingkun Yan, Sheng Xu, Jean J de la Rosette, Maria J Merino, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
OBJECTIVE: Approximately 15% of patients who undergo radical prostatectomy (RP) for prostate cancer develop local recurrence, which is heralded by a rise in serum prostate-specific antigen (PSA) levels. Early detection and treatment of recurrence improves the outcome of salvage treatment. We investigated the ability of multiparametric magnetic resonance imaging (mpMRI)-transrectal ultrasound (TRUS) fusion-guided biopsy (FGB) combined with "cognitive biopsy" to confirm local recurrence of prostate cancer after RP...
October 2015: Urologic Oncology
Benjamin W Lamb, Wei Shen Tan, Attia Rehman, Afsara Nessa, Daniel Cohen, John O'Neil, James S A Green, John E W Hines
INTRODUCTION: Prebiopsy multiparametric magnetic resonance imaging (MRI) is increasingly used in clinical practice to detect clinically significant prostate cancer, although its role is controversial. We audited the accuracy of prebiopsy MRI for men clinically suspected to have prostate cancer who underwent initial transrectal ultrasound (TRUS) biopsy at our institution. PATIENTS AND METHODS: All patients who had a prebiopsy prostate MRI and initial TRUS prostate biopsy from January 1, 2013 to December 31, 2013 were included in the study...
December 2015: Clinical Genitourinary Cancer
Paul Davis, Eldho Paul, Jeremy Grummet
INTRODUCTION: Prostate biopsy remains the gold standard for prostate cancer diagnosis. The field of prostate biopsy is undergoing a rapid change. This study aims to provide a snapshot of the current practice of prostate biopsy in the Urological Society of Australia and New Zealand (USANZ). MATERIALS AND METHODS: A 31-question multiple-choice survey was constructed using a web-based provider and was distributed to 644 members of USANZ. The questionnaire addressed various aspects of prostate biopsy...
July 2015: Urology Annals
A Latifoltojar, N Dikaios, A Ridout, C Moore, R Illing, A Kirkham, S Taylor, S Halligan, D Atkinson, C Allen, M Emberton, S Punwani
BACKGROUND: To determine the evolution of prostatic multi-parametric magnetic resonance imaging (mp-MRI) signal following transrectal ultrasound (TRUS)-guided biopsy. METHODS: Local ethical permission and informed written consent was obtained from all the participants (n=14, aged 43-69, mean 64 years). Patients with a clinical suspicion of prostate cancer (PSA range 2.2-11.7, mean 6.2) and a negative (PIRAD 1-2/5) pre-biopsy mp-MRI (pre-contrast T1, T2, diffusion-weighted and dynamic-contrast-enhanced MRI) who underwent 10-core TRUS-guided biopsy were recruited for additional mp-MRI examinations performed at 1, 2 and 6 months post biopsy...
December 2015: Prostate Cancer and Prostatic Diseases
Daniel N Costa, Yair Lotan, Neil M Rofsky, Claus Roehrborn, Alexander Liu, Brad Hornberger, Yin Xi, Franto Francis, Ivan Pedrosa
PURPOSE: We assess the performance of prospectively assigned magnetic resonance imaging based Likert scale scores for the detection of clinically significant prostate cancer, and analyze the pre-biopsy imaging variables associated with increased cancer detection using targeted magnetic resonance imaging-transrectal ultrasound fusion biopsy. MATERIALS AND METHODS: In this retrospective review of prospectively generated data including men with abnormal multiparametric prostate magnetic resonance imaging (at least 1 Likert score 3 or greater lesion) who underwent subsequent targeted magnetic resonance imaging-transrectal ultrasound fusion biopsy, we determined the association between different imaging variables (Likert score, lesion size, lesion location, prostate volume, radiologist experience) and targeted biopsy positivity rate...
January 2016: Journal of Urology
Sangeet Ghai, John Trachtenberg
Recent advances in multiparametric magnetic resonance imaging (mp-MRI) have led to a paradigm shift in the diagnosis and management of prostate cancer (PCa). Its sensitivity in detecting clinically significant cancer and the ability to localize the tumor within the prostate gland has opened up discussion on targeted diagnosis and therapy in PCa. Use of mp-MRI in conjunction with prostate-specific antigen followed by targeted biopsy allows for a better diagnostic pathway than transrectal ultrasound (TRUS) biopsy and improves the diagnosis of PCa...
July 2015: Indian Journal of Urology: IJU: Journal of the Urological Society of India
Camille Lanz, François Cornud, Frédéric Beuvon, Arnaud Lefèvre, Paul Legmann, Marc Zerbib, Nicolas Barry Delongchamps
PURPOSE: We evaluated the accuracy of prostate magnetic resonance imaging- transrectal ultrasound targeted biopsy for Gleason score determination. MATERIALS AND METHODS: We selected 125 consecutive patients treated with radical prostatectomy for a clinically localized prostate cancer diagnosed on magnetic resonance imaging-transrectal ultrasound targeted biopsy and/or systematic biopsy. On multiparametric magnetic resonance imaging each suspicious area was graded according to PI-RADS™ score...
January 2016: Journal of Urology
Yonglin Li, Zhengyan Tang, Lin Qi, Zhi Chen, Dongjie Li, Mingqiang Zeng, Ruizhi Xue, Chuan Peng
OBJECTIVE: To establish logistic regression model for prostate cancer and provide basis for prostate biopsy.
 METHODS: A total of 117 cases of prostate biopsy were retrospectively analyzed in chronological sequence. All cases were assigned into a model group (n=78) and a validation group (n=39). Logistic regression model was established and its value was estimated by receiver operating characteristic (ROC) curve. 
 RESULTS: Digital rectal examination(DRE), transrectal ultrasound(TRUS), MRI, prostate-specific antigen density (PSAD), and free PSA/total PSA (fPSA/tPSA) were the influential factors for prostate biopsy (P<0...
June 2015: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
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