keyword
https://read.qxmd.com/read/38538095/infectious-aortitis-and-managing-it-at-a-community-military-hospital
#1
JOURNAL ARTICLE
Kelly Tang, Brandon Ford, Samuel L Grasso, Jonathan Swisher
Infectious aortitis is a rare disease process which can be of fungal, viral or bacterial aetiology. This disease process is often incidentally found during concomitant infectious processes, likely due to haematogenous spread. Common sources are from cardiac, genitourinary and gastroenterologic sources. CT imaging of the aorta is essential in identifying physiological changes-wall thickness changes, ectasia and stenosis. We present a case of a female in her early 60s with a medical history of cardiomyopathy with heart failure and reduced ejection fraction, who was initially admitted for acute cholecystitis complicated by the development of gallstone pancreatitis...
March 27, 2024: BMJ Case Reports
https://read.qxmd.com/read/38537125/efficacy-of-a-novel-antibiotic-drug-combination-toward-multidrug-resistant-ocular-pathogens
#2
JOURNAL ARTICLE
Lakshminarayanan Gowtham, Rachel A F Wozniak, Paul M Dunman, Esther Sheba, Prashant Garg, Joveeta Joseph
PURPOSE: Antimicrobial resistance is a global health threat, compounded by the reduction in the discovery of new antibiotics. A repurposed drugs-based approach could provide a viable alternative for the treatment of multidrug-resistant (MDR) bacterial infections. In this study, we sought to evaluate the in vitro efficacy of a novel drug combination, polymyxin B/trimethoprim (PT) + rifampin on MDR isolates from patients with bacterial keratitis in India. METHODS: Forty-three isolates, which included 20 Staphylococcus aureus, 19 Pseudomonas aeruginosa, 3 Pseudomonas stutzeri, and 1 Acinetobacter baumannii, were evaluated for their antibiotic resistance by minimum inhibitory concentration (MIC)...
March 26, 2024: Cornea
https://read.qxmd.com/read/38529622/rifampin-and-silymarin-mediated-pharmacokinetic-interactions-of-exogenous-and-endogenous-substrates-in-a-transgenic-oatp1b-mouse-model
#3
JOURNAL ARTICLE
Baron J Bechtold, Katherine D Lynch, Victoria O Oyanna, M Ridge Call, Tyler N Graf, Nicholas H Oberlies, John D Clarke
Organic anion-transporting polypeptides (OATP) 1B1 and OATP1B3, encoded by the SLCO gene family of the solute carrier superfamily, are involved in the disposition of many exogenous and endogenous compounds. Preclinical rodent models help assess risks of pharmacokinetic interactions, but interspecies differences in transporter orthologs and expression limit direct clinical translation. An OATP1B transgenic mouse model comprising a rodent Slco1a/1b gene cluster knockout and human SLCO1B1 and SLCO1B3 gene insertions provides a potential physiologically relevant preclinical tool to predict pharmacokinetic interactions...
March 26, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38517016/implant-retention-in-a-rabbit-model-of-fracture-related-infection
#4
JOURNAL ARTICLE
Jan Puetzler, Alejandro Vallejo Diaz, Georg Gosheger, Martin Schulze, Daniel Arens, Stephan Zeiter, Claudia Siverino, Robert G Richards, Thomas F Moriarty
AIMS: Fracture-related infection (FRI) is commonly classified based on the time of onset of symptoms. Early infections (< two weeks) are treated with debridement, antibiotics, and implant retention (DAIR). For late infections (> ten weeks), guidelines recommend implant removal due to tolerant biofilms. For delayed infections (two to ten weeks), recommendations are unclear. In this study we compared infection clearance and bone healing in early and delayed FRI treated with DAIR in a rabbit model...
March 22, 2024: Bone & Joint Research
https://read.qxmd.com/read/38514367/brucellosis-in-a-patient-with-crohn-s-disease-treated-with-infliximab-a-case-report
#5
JOURNAL ARTICLE
Mansour Altuwaijri, Nasser Alkhraiji, Mosaab Almasry, Saad Alkhowaiter, Nuha Al Amaar, Ammar Alotaibi
Crohn's disease (CD) is an inflammatory disease that can affect any part of the gastrointestinal tract and presents with myriad symptoms. Various treatments, including biological treatments, are available. The use of biologics increases the risk of opportunistic infections, with no association with serious infections (1). To the best of our knowledge, there are no established recommendations or case studies for patients with CD infected with Brucella being actively treated with biologics and immunomodulators to date...
March 21, 2024: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://read.qxmd.com/read/38514165/hepatic-veno-occlusive-disease-complicated-with-extreme-hyperammonaemia-920-%C3%A2%C2%B5mol-l-treated-with-defibrotide-lactulose-rifampin-and-haemodialysis
#6
JOURNAL ARTICLE
Maciej Kabat, Sarvarinder Gill, Kevin Kim, Karan Omidvari, Robert Lee
Hepatic veno-occlusive disease (VOD)/sinusoidal obstructive syndrome (SOS) is a severe complication that can occur following haematopoietic stem cell transplant (HSCT) with high-intensity conditioning chemotherapy regimens. Severe VOD/SOS, often characterised by multiorgan failure, is associated with a high mortality rate. This case report details the complex clinical course of a male patient in his mid-20s, recently diagnosed with B cell acute lymphoblastic leukaemia, who underwent allogeneic HSCT. Based on the 2023 European Society for Blood and Marrow Transplantation (EBMT) criteria, the patient developed very severe VOD/SOS, prompting immediate treatment with defibrotide...
March 21, 2024: BMJ Case Reports
https://read.qxmd.com/read/38498113/unveiling-the-repressive-mechanism-of-a-pps-like-regulator-pspr-in-polyhydroxyalkanoates-biosynthesis-network
#7
JOURNAL ARTICLE
Junyu Chen, Yinglu Cui, Shengjie Zhang, Bian Wu, Jing Han, Hua Xiang
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a type of polyhydroxyalkanoates (PHA) that exhibits numerous outstanding properties and is naturally synthesized and elaborately regulated in various microorganisms. However, the regulatory mechanism involving the specific regulator PhaR in Haloferax mediterranei, a major PHBV production model among Haloarchaea, is not well understood. In our previous study, we showed that deletion of the phosphoenolpyruvate (PEP) synthetase-like (pps-like) gene activates the cryptic phaC genes in H...
March 18, 2024: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/38494918/a-case-to-support-the-continued-use-of-rifampin-in-clinical-drug-drug-interaction-studies
#8
JOURNAL ARTICLE
Joel P Bercu, David J Ponting, Sharon L Ripp, Krista L Dobo, Rheem A Totah, Jayaprakasam Bolleddula
No abstract text is available yet for this article.
March 18, 2024: Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38494905/quantification-of-rifampicin-loaded-into-inhaled-polymeric-nanoparticles-by-reversed-phase-high-performance-liquid-chromatography-in-pulmonary-nonphagocytic-cellular-uptake
#9
JOURNAL ARTICLE
Scolari Ivana Romina, De La Cruz-Thea Benjamín, Musri Melina Mara, Granero Gladys Ester
Rifampicin is an antibiotic effective against both Gram-negative and Gram-positive bacteria and is commonly used as a first-line treatment for tuberculosis caused by Mycobacterium tuberculosis . In this study, a reversed-phase high-performance liquid chromatography method was developed and validated to assess rifampicin, either free or combined with ascorbic acid, loaded into chitosan/Tween 80-coated alginate nanoparticles. The method utilized a reversed-phase C18 Restek column with specific chromatographic conditions: a mobile phase of 60 : 40 ratios of methanol/buffer phosphate (pH 7...
March 18, 2024: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/38493570/longitudinal-antimicrobial-susceptibility-trends-of-canine-staphylococcus-pseudintermedius
#10
JOURNAL ARTICLE
Caroline Calabro, Ritwik Sadhu, Yuchen Xu, Melissa Aprea, Cassandra Guarino, Casey L Cazer
Antimicrobial resistance within Staphylococcus pseudintermedius poses a significant risk for the treatment of canine pyoderma and as a reservoir for resistance and potential zoonoses, but few studies examine long-term temporal trends of resistance. This study assesses the antimicrobial resistance prevalence and minimum inhibitory concentration (MIC) trends in S. pseudintermedius (n=1804) isolated from canine skin samples at the Cornell University Animal Health Diagnostic Center (AHDC) between 2007 and 2020...
March 12, 2024: Preventive Veterinary Medicine
https://read.qxmd.com/read/38490710/cervical-lymphadenitis-from-mycobacterium-avium-complex
#11
JOURNAL ARTICLE
Jared Coe, Yoram Puius, Harsh Jain, Eric A Meyerowitz
We present an instructive case of cervical lymphadenitis in a young man without a history of HIV infection. The patient developed spontaneous left-sided neck swelling that progressed over 4 months. CT imaging demonstrated a necrotic left-sided neck mass within the cervical lymph node chain. He was initially prescribed azithromycin and rifampin for presumed cat scratch disease with improvement but incomplete resolution of symptoms. Blood cultures ordered 2 months later grew Mycobacterium avium complex (MAC) and the patient had an excellent clinical response to MAC therapy...
March 15, 2024: BMJ Case Reports
https://read.qxmd.com/read/38485279/-cyp7a1-gene-induction-via-shp-dependent-or-independent-mechanisms-can-increase-the-risk-of-drug-induced-liver-injury-independently-or-in-synergy-with-bsep-inhibition
#12
JOURNAL ARTICLE
Congrong Niu, Xiaodong Xie, Renmeng Liu, Xiaomin Liang, Yiding Hu, Yurong Lai
Drug-induced liver injury (DILI) is a frequent cause of clinical trial failures during drug development. While inhibiting BSEP is a well-documented DILI mechanism, interference with genes related to bile acid (BA) metabolism and transport can further complicate DILI development. Here, the effects of twenty-eight compounds on genes associated with BA metabolism and transport were evaluated, including those with discontinued development or use, boxed warnings, and clean labels for DILI. The study also included rifampicin and omeprazole, PXR and AhR ligands, and four mitogen-activated protein kinase kinase (MEK1/2) inhibitors...
March 14, 2024: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://read.qxmd.com/read/38482083/rare-case-of-mycobacterium-avium-complex-peritonitis-in-a-patient-with-multiple-myeloma-undergoing-peritoneal-dialysis
#13
Sacide S Ozgur, Nida Ansari, Dhruv Patel, Ryan Rahman, Raymond Shih
Mycobacterium avium complex (MAC) infections can present as a variety of severe diseases. While it has a predilection for immunocompromised patients such as those with Human immunodeficiency virus (HIV), it can also affect immunocompetent patients as well. One of the rare yet severe diseases that MAC infections can present is MAC peritonitis. Often hard to distinguish from other causes of peritonitis, high clinical suspicion should be maintained for those who are susceptible. Here we present an 85-year-old female with a past medical history of end-stage renal disease on peritoneal dialysis who presented with nausea and vomiting...
2024: Journal of Community Hospital Internal Medicine Perspectives
https://read.qxmd.com/read/38466092/targeted-sequencing-from-cerebrospinal-fluid-for-rapid-identification-of-drug-resistant-tuberculous-meningitis
#14
JOURNAL ARTICLE
Trinh Thi Bich Tram, Le Pham Tien Trieu, Le Thanh Hoang Nhat, Do Dang Anh Thu, Nguyen Le Quang, Nguyen Duc Bang, Tran Thi Hong Chau, Guy E Thwaites, Timothy M Walker, Vu Thi Ngoc Ha, Nguyen Thuy Thuong Thuong
Mortality from tuberculous meningitis (TBM) remains around 30%, with most deaths occurring within 2 months of starting treatment. Mortality from drug-resistant strains is higher still, making early detection of drug resistance (DR) essential. Targeted next-generation sequencing (tNGS) produces high read depths, allowing the detection of DR-associated alleles with low frequencies. We applied Deeplex Myc-TB-a tNGS assay-to cerebrospinal fluid (CSF) samples from 72 adults with microbiologically confirmed TBM and compared its genomic drug susceptibility predictions to a composite reference standard of phenotypic susceptibility testing (pDST) and whole genome sequencing, as well as to clinical outcomes...
March 11, 2024: Journal of Clinical Microbiology
https://read.qxmd.com/read/38463079/an-unusual-imaging-presentation-of-pediatric-bacterial-meningoencephalitis-a-case-report-study
#15
Maryam Kachuei, Ramin Zare, Shirin Sayyahfar, Mitra Khalili, Hamidreza Movahedi, Mobin Naghshbandi, Shayan Eghdami
BACKGROUND: Bacterial meningoencephalitis is a serious infection affecting the brain and its surrounding membranes. While imaging studies play a crucial role in diagnosing this condition, the typical radiological findings are well-documented. However, this case report describes an unusual imaging presentation that deviates from the expected patterns, emphasizing the need for awareness of such variations. CASE PRESENTATION: A 7-year-old female with no prior medical history was referred to our hospital with fever, seizure, and loss of Consciousness...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38458396/common-and-varied-molecular-responses-of-escherichia-coli-to-five-different-inhibitors-of-the-lipopolysaccharide-biosynthetic-enzyme-lpxc
#16
JOURNAL ARTICLE
Anna-Maria Möller, Melissa Vázquez-Hernández, Blanka Kutscher, Raffael Brysch, Simon Brückner, Emily C Marino, Julia Kleetz, Christoph Hr Senges, Sina Schäkermann, Julia E Bandow, Franz Narberhaus
A promising yet clinically unexploited antibiotic target in difficult-to-treat Gram-negative bacteria is LpxC, the key enzyme in the biosynthesis of lipopolysaccharides (LPS), which are the major constituents of the outer membrane. Despite the development of dozens of chemically diverse LpxC inhibitor molecules, it is essentially unknown how bacteria counteract LpxC inhibition. Our study provides comprehensive insights into the response against five different LpxC inhibitors. All compounds bound to purified LpxC from Escherichia coli...
March 6, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38456025/an-unusual-case-of-brucella-melitensis-related-wound-infection
#17
Ozge Alkan Bilik, Fatma Meral Ince, Nida Ozcan, Zeynep Ayaydin
BACKGROUND: Brucellosis is an anthropo-zoonotic infectious disease caused by various Brucella species. It is usually transmitted through contact with infected animals or consumption of contaminated animal products. Brucellosis most commonly affects the musculoskeletal and reticuloendothelial system with additional involvement observed in gastrointestinal system, urinary tract, reproductive system, central nervous system, and cardiovascular system. Skin involvement is extremely rare in brucellosis...
2024: Le Infezioni in Medicina
https://read.qxmd.com/read/38452928/cystic-neutrophlic-granulomatous-mastitis-in-pregnancy
#18
EDITORIAL
John C Kingdom, Jeannie Richardson, Gary Ko, Ralph George
No abstract text is available yet for this article.
March 5, 2024: Journal of Obstetrics and Gynaecology Canada: JOGC
https://read.qxmd.com/read/38451889/ceftaroline-for-central-nervous-system-infections-case-report-of-a-young-infant-and-scoping-review
#19
JOURNAL ARTICLE
Haley Urbach, Nicole Sileo, Sergio Lerma, Kevin Nguyen, Giordano Sosa Soto, Marisa Nielsen, Amy Heiderich, James Holsapple, Sharon Vuppula, Jeffrey I Campbell
BACKGROUND: Managing health care acquired and device-associated intracranial infections in young children can be challenging given adverse antibiotic side effects and difficulties in achieving adequate central nervous system (CNS) antibiotic concentrations. Ceftaroline is a cephalosporin with a favorable safety profile and activity against methicillin-resistant Staphylococci and several Gram-negative organisms. Published data on the use of ceftaroline for CNS infections in children and adults are limited...
March 4, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38447130/retinal-vasculitis-in-a-patient-with-hansen-s-disease
#20
JOURNAL ARTICLE
Shravan V Savant, Sarkis H Soukiasian, Richard F Spaide, Kendra A Klein-Mascia
PURPOSE: Hansen's disease is endemic in over 140 countries worldwide and a potentially blinding condition. We describe a case of retinal vasculitis in a patient with Hansen's disease with concomitant positive antiphospholipid antibody serology, a potentially under-reported complication in this setting. METHODS: A 37-year-old Brazilian man systemically stable on triple therapy (clofazimine, rifampin, dapsone) for Hansen's disease presented for a comprehensive ophthalmic evaluation...
March 4, 2024: Retinal Cases & Brief Reports
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